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https://www.readbyqxmd.com/read/29911323/regulation-of-p38-mitogen-activated-kinase-mediated-fetal-membrane-senescence-by-statins
#1
Martina T Ayad, Brandie D Taylor, Ramkumar Menon
PROBLEM: Oxidative stress (OS)-induced, p38 mitogen-activated protein kinase (p38MAPK)-mediated chorioamniotic senescence and inflammation (senescence-associated secretory phenotype [SASP]) are associated with parturition. In response to OS-inducing risk factors, premature senescence contributes to preterm premature rupture of the membranes (pPROM) and spontaneous preterm birth (PTB). We determined the effect of simvastatin, rosuvastatin, and progesterone in downregulating p38MAPK-mediated senescence and SASP...
June 17, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29905673/blood-brain-barrier-dysfunction-after-smoke-inhalation-injury-with-and-without-skin-burn
#2
Anita C Randolph, Satoshi Fukuda, Koji Ihara, Perenlei Enkhbaatar, Maria-Adelaide Micci
Only a handful of published reports exist today that describe neurological complications following smoke inhalation injury. In this study, we characterize acute pathophysiological changes in the brain of sheep exposed to smoke inhalation, with- and without third-degree skin burn that models the injuries sustained by human victims of fire accidents. Blood-brain barrier integrity and hemorrhage were analyzed throughout the brain using specific histological stains: Hematoxylin & Eosin, Luxol fast blue, Periodic acid-Schiff (PAS), and Martius, Scarlet and Blue (MSB)...
June 13, 2018: Shock
https://www.readbyqxmd.com/read/29905462/the-human-biomolecular-corona-of-liposomal-doxorubicin-the-overlooked-factor-in-anticancer-drug-delivery
#3
Giulio Caracciolo, Sara Palchetti, Luca Digiacomo, Riccardo Zenezini Chiozzi, Anna Laura Capriotti, Heinz Amenitsch, Paolo Maria Tentori, Valentina Palmieri, Massimiliano Papi, Francesco Cardarelli, Daniela Pozzi, Aldo Laganà
More than twenty years after its approval by the Food and Drug Administration (FDA) liposomal doxorubicin (DOX) is still the drug of choice for the treatment of breast cancer and other conditions such as ovarian cancer and multiple myeloma. Yet, despite the efforts, liposomal DOX did not satisfy expectations at the clinical level. When liposomal drugs enter a physiological environment, their surface gets coated by a dynamic biomolecular corona (BC). The BC changes liposome's synthetic identity, providing it with a new one, referred to as 'biological identity' (size, aggregation state, and BC composition)...
June 15, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29900649/rounding-precedes-rupture-and-breakdown-of-vacuolar-membranes-minutes-before-malaria-parasite-egress-from-erythrocytes
#4
Svetlana Glushakova, Josh R Beck, Matthias Garten, Brad L Busse, Armiyaw S Nasamu, Tatyana Tenkova-Heuser, John Heuser, Daniel Goldberg, Joshua Zimmerberg
Because Plasmodium falciparum replicates inside of a parasitophorous vacuole (PV) within a human erythrocyte, parasite egress requires the rupture of two limiting-membranes. Parasite Ca2+, kinases, and proteases contribute to efficient egress; their coordination in space and time is not known. Here the kinetics of parasite egress were linked to specific steps with specific compartment markers, using live cell microscopy of parasites expressing PV-targeted fluorescent proteins, and specific egress inhibitors...
June 13, 2018: Cellular Microbiology
https://www.readbyqxmd.com/read/29897246/stability-of-biological-membranes-upon-mechanical-indentation
#5
Florian Franz, Camilo Andrés Aponte-Santamaría, Csaba Daday, Vedran Miletić, Frauke Gräter
Mechanical perturbations are ubiquitous in living cells, and many biological functions are dependent on the mechanical response of lipid membranes. Recent force-spectroscopy studies have captured the step-wise fracture of stacks of bilayers, avoiding substrate effects. However, the effect of stacking bilayers, as well as the exact molecular mechanism of the fracture process, is unknown. Here, we use atomistic and coarse-grained force-clamp Molecular Dynamics simulations to assess the effects of mechanical indentation on stacked and single bilayers...
June 13, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29896195/cholesterol-crystal-mediated-inflammation-is-driven-by-plasma-membrane-destabilization
#6
Fei Shu, Jiahuan Chen, Xiaojie Ma, Yunzhou Fan, Li Yu, Wencheng Zheng, Matthias W Amrein, Tie Xia, Yan Shi
Atherosclerosis is driven by an inflammatory milieu in the walls of artery vessels. Initiated early in life, it progresses to plaque formation and form cell accumulation. A culprit in this cascade is the deposition of cholesterol crystals (CC). The involvement of smaller crystals in the early stage of atherosclerotic changes may be critical to the long-term pathological development. How these small crystals initiate the pro-inflammatory events is under study. We report here an unexpected mechanism that microscopic CC interact with cellular membrane in a phagocytosis-independent manner...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29895996/maternal-and-early-perinatal-outcomes-of-triplet-pregnancy-study-of-82-triplets-from-a-single-perinatal-centre-in-south-india
#7
Priya Rajan, Srinivas Murki, Suseela Vavilala, Nirupama Surubhotla
Objectives: To study the recent trends in maternal and perinatal outcomes of triplet pregnancy from a perinatal centre in South India. Methods: All triplet pregnancies booked at Fernandez hospital, Hyderabad (a tertiary care perinatal centre in South India), or those referred between 2000 and 2014 were included in the study. The maternal, fetal and neonatal outcome and any interventions like cerclage, steroid administration were studied. Results: There were 82 triplet deliveries over the study period of 15 years (82 per 69,584 live births)...
June 2018: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/29892034/gastric-fluid-used-to-assess-changes-during-the-latency-period-in-preterm-prelabor-rupture-of-membranes
#8
Ivana Musilova, Ctirad Andrys, Helena Hornychova, Lenka Pliskova, Marcela Drahosova, Barbora Zednikova, Radka Bolehovska, Tomas Faist, Bo Jacobsson, Marian Kacerovsky
OBJECTIVE: To determine changes in the intraamniotic environment during the latency period using paired amniotic and gastric fluid samples in pregnancies complicated by preterm prelabor rupture of membranes (PPROM). METHODS: A total of 34 women with singleton pregnancies complicated by PPROM prior to 34 weeks were included in the study. Amniotic fluid was obtained by transabdominal amniocentesis at the time of admission. Immediately after delivery, umbilical cord blood and gastric fluid were obtained...
May 31, 2018: Pediatric Research
https://www.readbyqxmd.com/read/29891663/high-speed-microjets-issue-from-bursting-oil-gland-reservoirs-of-citrus-fruit
#9
Nicholas M Smith, Hossein Ebrahimi, Ranajay Ghosh, Andrew K Dickerson
The rupture of oil gland reservoirs housed near the outer surface of the citrus exocarp is a common experience to the discerning citrus consumer and bartenders the world over. These reservoirs often rupture outwardly in response to bending the peel, which compresses the soft material surrounding the reservoirs, the albedo, increasing fluid pressure in the reservoir. Ultimately, fluid pressure exceeds the failure strength of the outermost membrane, the flavedo. The ensuing high-velocity discharge of oil and exhaustive emptying of oil gland reservoirs creates a method for jetting small quantities of the aromatic oil...
June 11, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29886928/short-term-cadmium-exposure-induces-gas-exchanges-morphological-and-ultrastructural-disturbances-in-mangrove-avicennia-schaueriana-young-plants
#10
Janaina S Garcia, Ândrea C Dalmolin, Priscila A Cortez, Paulo S Barbeira, Pedro A O Mangabeira, Marcel G C França
Mangroves have been subject to more metal contamination, including cadmium (Cd). This study evaluated if a relatively short Cd exposure may induce metabolic, morphological and ultrastructural cell disturbance in Avicennia schaueriana. Cd induced evident constraints to seedlings since there was reduction in leaf gas exchanges and the plants did not survive for more than 10 days at a higher Cd exposure in controlled conditions. The highest Cd accumulation was observed in roots and gradually less in stem and leaves...
June 2018: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/29886805/psychosocial-and-biological-paternal-role-in-pregnancy-outcomes
#11
Maryam Kashanian, Masoomeh Faghankhani, Hasti Hadizadeh, MMasoud Salehi, Masoomeh YousefzadehRoshan, Mohammad EhsaniPour, Ladan Sayyah, Narges Sheikhansari
BACKGROUND: Pregnancy outcomes are affected by many different factors. One of the influential factors on pregnancy outcomes is the male partner as an important person to mother's wellbeing. OBJECTIVE: The aim of the present study was to investigate the effects of male partner's role including socioeconomic support, emotional support, accompanying pregnant women during prenatal care visits (PNC) and labor, and the level of pregnant women's satisfaction from their partners' support and involvement during pregnancy on pregnancy outcomes...
June 10, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29886784/influence-of-mbl2-and-nos3-polymorphisms-on-spontaneous-preterm-birth-in-north-east-brazil-genetics-and-preterm-birth
#12
Lícia Vasconcelos Carvalho da Silva, Natassia Javorski, Lucas André Cavalcanti Brandão, Marília de Carvalho Lima, Sergio Crovella, Sophie Helena Eickmann
BACKGROUND: The mannose-binding lectin (MBL2) and nitric oxide synthase 3 (NOS3) genes are associated with the immune response against inflammatory processes, have been reported as possibly related with premature birth. Until now, most of the researches regarding the genetic influence of prematurity have revealed limited results because only investigating the child or the mothers' genotypes, thus not exploring the possible effects of interactions between these genotypes or the interactions with environmental factors related to the duration of pregnancy...
June 10, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29886779/does-intact-umbilical-cord-milking-increase-infection-rates-in-preterm-infants-with-premature-prolonged-rupture-of-membranes
#13
Juan Li, Bo Yu, Wei Wang, Luo, Qian-Ling Dai, Xiao-Qin Gan
OBJECTIVE: To investigate whether intact umbilical cord milking (I-UCM) can aggravate infection or result in other undesirable complications in preterm infants with premature prolonged rupture of membranes (PPROM). METHODS: Neonates vaginally delivered between 28 and 37 weeks' gestation and complicated by PPROM before birth were randomly divided into two groups according to the cord clamping procedure: I-UCM before clamping and immediate cord clamping (ICC). Various parameters of the study participants were compared between the two groups...
June 10, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29886774/labor-induction-in-indicated-moderate-to-late-preterm-birth
#14
Charline Bertholdt, Olivier Morel, Matthieu Dap, Marion Choserot, Hélène Minebois
INTRODUCTION: The primary objective of the study was to evaluate the success of labor induction for indicated moderate and late preterm birth. As secondary objectives, the mode of delivery was assessed. MATERIAL AND METHODS: This is an observational study conducted in a tertiary care unit between 2013 and 2015. All patients who underwent labor induction for indicated preterm birth between 32 + 0 and 36 + 6 weeks of gestation (as premature rupture of membranes, preeclampsia, intrauterine growth restriction, fetomaternal alloimmunization, or intrahepatic cholestasis) were included...
June 10, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29886769/the-effect-of-activity-restriction-on-infant-s-birth-weight-and-gestational-age-at-birth-prams-data-analysis
#15
Abeer Omar
BACKGROUND: Activity restriction is extensively prescribed for pregnant women with major comorbidities despite the lack of evidence to support its effectiveness in preventing preterm birth or low birth weight. PURPOSE: To determine the moderation effect of home activity restriction for more than a week on infant's birth weight and gestational age at birth for high-risk women with obstetrical and medical comorbidities. METHODS: A secondary analysis of 2004-2008 New York Pregnancy Risk Assessment Monitoring System was conducted with 1426 high-risk women...
January 1, 2018: Canadian Journal of Nursing Research, Revue Canadienne de Recherche en Sciences Infirmières
https://www.readbyqxmd.com/read/29883049/accessory-maxillary-ostium-repair-using-middle-turbinate-flap-a-case-series-of-116-patients-with-chronic-rhinosinusitis
#16
Matti Penttilä
BACKGROUND: The ostiomeatal complex (OMC), comprising a small natural maxillary sinus ostium and narrow infundibulum, transmits the air diffusion into the antrum and mucociliary transport from the antrum, and is considered a key area in chronic rhinosinusitis (CRS). Thin membranous anterior and posterior fontanelle areas below the OMC can rupture forming a perforation, accessory maxillary ostium (AMO), that increases antral airflow changing the anatomy and function of the sinus. The purpose of this study was to report the first case series of CRS patients who had undergone repair of fontanelle defects aiming to reconstruct normal structures...
June 8, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29880168/amniotic-fluid-index-single-deepest-pocket-and-transvaginal-cervical-length-parameter-of-predictive-delivery-latency-in-preterm-premature-rupture-of-membranes
#17
Young-Joo Lee, Seung-Chul Kim, Jong-Kil Joo, Dong-Hyung Lee, Ki-Hyung Kim, Kyu-Sup Lee
OBJECTIVE: Prediction of delivery latency complicated with preterm premature rupture of membrane (PPROM) is crucial for reducing maternal and neonatal complications. Therefore, we investigated the correlations between latency period and cut-off values of ultrasonographic parameters, ultimately predicting delivery latency. MATERIALS AND METHODS: The retrospective study was performed on 121 PPROM patients enrolled between March 2010 and July 2015. Parameters including amniotic fluid index (AFI), single deepest pocket (SDP) and transvaginal cervical length (TVCL) were measured in 99 singleton pregnancies with PPROM...
June 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29880163/effect-of-twin-pregnancy-chorionic-properties-on-maternal-and-fetal-outcomes
#18
Bibo Feng, Jianjun Zhai, Yu Cai
OBJECTIVE: This study aimed to determine the effect of twin pregnancy chorionic properties on pregnancy complications and fetal outcomes. MATERIALS AND METHODS: A total of 559 subjects with gemellary pregnancy were included in the retrospective analysis, and clinical data, such as monitoring data during pregnancy and maternal and fetal outcomes, were recorded in detail. Based on the ultrasound results and methods of the postpartum pathologic examination of the placental membranes, the subjects were divided into the twin group with monochorionic diamnion (MCDA group, n = 198) and twin group with dichorionic diamnion (DCDA group, n = 361)...
June 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29879190/vitamin-d-binding-protein-in-cervicovaginal-fluid-as-a-non-invasive-predictor-of-intra-amniotic-infection-and-impending-preterm-delivery-in-women-with-preterm-labor-or-preterm-premature-rupture-of-membranes
#19
Song Yi Kook, Kyo Hoon Park, Ji Ae Jang, Yu Mi Kim, Hyunsoo Park, Se Jeong Jeon
OBJECTIVE: To determine whether vitamin D-binding protein (VDBP) in cervicovaginal fluid (CVF) is independently predictive of intra-amniotic infection and imminent spontaneous preterm delivery (SPTD, delivery within 48 hours) in women with preterm labor with intact membranes (PTL) or preterm premature rupture of membranes (PPROM). METHOD: This was a single-center retrospective cohort study. CVF samples for VDBP assays were obtained along with serum C-reactive protein (CRP) levels immediately after amniocentesis in consecutive women with PTL (n = 148) or PPROM (n = 103) between 23...
2018: PloS One
https://www.readbyqxmd.com/read/29878553/predicting-premature-preterm-rupture-of-the-membranes-after-fetal-surgery
#20
Michael A Belfort
Premature preterm rupture of the membranes (PPROM) complicates fetal surgery in 23% of open neural tube defect repairs.(Moldenhauer et al. Fetal Diagn Ther 2015) PPROM increases the risk of contractions and delivery as well as the risk of inflammation/infection for both mother and baby. Identification of those patients at risk for PPROM following fetal surgery would clearly be useful. This article is protected by copyright. All rights reserved.
June 7, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
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