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https://www.readbyqxmd.com/read/29676346/formal-saline-versus-honey-as-escharotic-in-the-conservative-management-of-major-omphaloceles
#1
Christopher O Bode, Adesoji O Ademuyiwa, Olumide A Elebute
Background: The use of honey as an escharotic agent in the conservative management of omphalocele major has not been widely explored in spite of its proven benefits in chronic wound management. We explored the use of local honey as an escharotic agent by comparing its use with 2.5% formal saline in the conservative management of major omphaloceles at the Lagos University Teaching Hospital, Lagos, Nigeria. Methods: From January 2006 to December 2009, 43 consecutive newborns with intact omphalocele major were alternately assigned into either Honey (H) or formal saline (FS) group...
January 2018: Nigerian Postgraduate Medical Journal
https://www.readbyqxmd.com/read/29676341/the-prevalence-and-risk-factors-for-trichomonas-vaginalis-infection-amongst-human-immunodeficiency-virus-infected-pregnant-women-attending-the-antenatal-clinics-of-a-university-teaching-hospital-in-lagos-south-western-nigeria
#2
Olaolopin Ijasan, Kehinde Sharafadeen Okunade, Ayodeji Ayotunde Oluwole
Background: Trichomonas vaginalis infection is the most prevalent non-viral sexually transmitted infection worldwide. Interactions between this infection and human immunodeficiency virus (HIV) may cause adverse pregnancy outcomes such as preterm labour, premature rupture of membranes, chorioamnionitis, low birth weight and post-abortal sepsis. Aims: This study was aimed to determine the prevalence and risk factors of T. vaginalis infection amongst HIV-positive pregnant women attending antenatal care at the Lagos University Teaching Hospital (LUTH), Lagos, Nigeria...
January 2018: Nigerian Postgraduate Medical Journal
https://www.readbyqxmd.com/read/29675491/hypertensive-disorders-of-in-vitro-fertilization-pregnancies-a-study-from-kosovo
#3
Merita Vuniqi-Krasniqi, Myrvete Paçarada, Qëndresë Daka, Zeqir Dervishi, Astrit Bimbashi, Kushtrim Dakaj
Background: Relationships between in-vitro fertilization (IVF), gestational hypertension, and pregnancy outcomes are demonstrated in a number of studies. However, it is still debated if IVF treatment or specific characteristics of infertile patients are responsible for worse obstetrical and neonatal outcomes. Objective: The aim of this study was to investigate maternal characteristics associated with hypertensive disorders (HD) in IVF conceived pregnancies and to assess the obstetrical and neonatal outcomes...
February 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/29673663/hmgb1-rage-signaling-pathway-in-pprom
#4
Huan Yan, Linlin Zhu, Zhan Zhang, Hong Li, Pengyun Li, Yan Wang, Maodong Leng
OBJECTIVE: Increased inflammation of the placenta is considered as a risk factor and a promoter of preterm premature rupture of the membranes (pPROM). High-mobility group box 1 (HMGB1) is a recently identified inflammatory cytokine, and HMGB1-RAGE signaling pathway has been associated with many pathophysiological processes. This study aims to reveal the mechanisms of HMGB1-RAGE signaling pathway in pPROM. MATERIALS AND METHODS: The mRNA levels of relative gene of HMGB1 pathway, HMGB1, RAGE, NF-κBp65, MMP-9 and MMP-2, were analyzed by real-time PCR in placentas collected from 60 normal term women, 60 women with PROM and 60 women with pPROM...
April 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29673597/sennoside-a-protects-mitochondrial-structure-and-function-to-improve-high-fat-diet-induced-hepatic-steatosis-by-targeting-vdac1
#5
Jiamei Le, Weiping Jia, Yongning Sun
Mitochondrial dysfunction is mainly associated with high-fat-diet (HFD)-induced hepatic steatosis. Sennoside A (SA), a commonly used clinical stimulant laxative, is reported to improve energy metabolism and insulin resistance. However, the effect and mechanism of SA on HFD-induced hepatic steatosis remain largely unknown. The aim of this study was to determine the effect and mechanism of SA on HFD-induced hepatic steatosis in mice. We examined the liver and body weight of mice to evaluate the physical changes in the liver...
April 16, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29673331/prevalence-and-factors-associated-with-preterm-birth-at-kenyatta-national-hospital
#6
Peter Wagura, Aggrey Wasunna, Ahmed Laving, Dalton Wamalwa, Paul Ng'ang'a
BACKGROUND: The World Health Organization estimates the prevalence of preterm birth to be 5-18% across 184 countries of the world. Statistics from countries with reliable data show that preterm birth is on the rise. About a third of neonatal deaths are directly attributed to prematurity and this has hindered the achievement of Millennium Development Goal-4 target. Locally, few studies have looked at the prevalence of preterm delivery and factors associated with it. This study determined the prevalence of preterm birth and the factors associated with preterm delivery at Kenyatta National Hospital in Nairobi, Kenya...
April 19, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29666685/identifying-risk-factors-for-healthcare-associated-infections-caused-by-carbapenem-resistant-acinetobacter-baumannii-in-a-neonatal-intensive-care-unit
#7
Amira M Sultan, Wael A Seliem
Objectives: Acinetobacter baumannii is a causative pathogen of various healthcare-associated infections (HAIs) and is particularly prevalent in high-risk hospital settings. This study aimed to determine risk factors associated with HAIs caused by carbapenem-resistant A. baumannii (CRAB) in a neonatal intensive care unit (NICU). Methods: This prospective study was performed between January 2013 and June 2014 among NICU patients at the Mansoura University Children's Hospital, Mansoura, Egypt...
February 2018: Sultan Qaboos University Medical Journal
https://www.readbyqxmd.com/read/29666477/single-cell-analysis-of-pyroptosis-dynamics-reveals-conserved-gsdmd-mediated-subcellular-events-that-precede-plasma-membrane-rupture
#8
Nathalia M de Vasconcelos, Nina Van Opdenbosch, Hanne Van Gorp, Eef Parthoens, Mohamed Lamkanfi
Pyroptosis is rapidly emerging as a mechanism of anti-microbial host defense, and of extracellular release of the inflammasome-dependent cytokines interleukin (IL)-1β and IL-18, which contributes to autoinflammatory pathology. Caspases 1, 4, 5 and 11 trigger this regulated form of necrosis by cleaving the pyroptosis effector gasdermin D (GSDMD), causing its pore-forming amino-terminal domain to oligomerize and perforate the plasma membrane. However, the subcellular events that precede pyroptotic cell lysis are ill defined...
April 17, 2018: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29664647/amphiphobic-septa-enhance-the-mechanical-stability-of-free-standing-bilayer-lipid-membranes
#9
Daichi Yamaura, Daisuke Tadaki, Shun Araki, Miyu Yoshida, Kohei Arata, Takeshi Ohori, Ken-Ichi Ishibashi, Miki Kato, Teng Ma, Ryusuke Miyata, Hideaki Yamamoto, Ryugo Tero, Masao Sakuraba, Toshio Ogino, Michio Niwano, Ayumi Hirano-Iwata
Artificial bilayer lipid membranes (BLMs) provide well-defined systems for investigating the fundamental properties of membrane proteins, including ion channels, and in screening the effect of drugs that act on them. However, the application of this technique is limited due to the low stability and low reconstitution efficiency of the process. We previously reported on improving the stability of BLM based on the fabrication of microapertures having a tapered edge in SiO2/Si3N4 septa and efficient ion channel incorporation based on vesicle fusion accelerated by a centrifugal force...
April 17, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29662817/concomitant-avulsion-injury-of-the-subclavian-vessels-and-the-main-bronchus-caused-by-blunt-trauma
#10
Dongsub Noh, Chan-Kyu Lee, Jung Joo Hwang, Hyun Min Cho
Concomitant rupture of the subclavian vessels and the left main bronchus caused by blunt trauma is a serious condition. Moreover, the diagnosis of a tracheobronchial injury with rupture of the subclavian vessels can be difficult. This report describes the case of a 33-year-old man who suffered from blunt trauma that resulted in the rupture of the left subclavian artery and vein. The patient underwent an operation for vascular control. On postoperative day 3, the left main bronchus was found to be transected on a computed tomography scan and bronchoscopy...
April 2018: Korean Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29662276/comparison-between-use-of-oral-misoprostol-versus-vaginal-misoprostol-for-induction-of-labour-at-term
#11
Prameela, Kavya D Sharma
Background and Objective: In modern obstetrics, around 30% of cases require induction of labour for various reasons. Misoprostol is gaining popularity as pharmacological inducing agent, though the route and dosage of administration are not standardised. The objective of the study is to compare the safety and efficacy of the two routes of misoprostol administration-oral (100 μg 4th hourly) and vaginal (25 μg 4th hourly), for induction of labour at term. Methods: In this randomised trial, 104 women having crossed the expected date of delivery without going into spontaneous labour and cases which had premature rupture of membranes <12 h were considered for labour induction and were divided into two equal groups...
April 2018: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/29660299/infection-induced-thrombin-production-a-potential-novel-mechanism-for-preterm-premature-rupture-of-membranes-pprom
#12
Liping Feng, Terrence K Allen, William P Marinello, Amy P Murtha
BACKGROUND: Preterm premature rupture of membranes (PPROM) is a leading contributor to maternal and neonatal morbidity and mortality. Epidemiologic and experimental studies have demonstrated that thrombin causes fetal membrane weakening and subsequently PPROM. Although blood is suspected as the likely source of thrombin in fetal membranes and amniotic fluid of patients with PPROM, this has not been proven. Ureaplasma Parvum (U. parvum) is emerging as a pathogen involved in prematurity, including PPROM, but until now, prothrombin production directly induced by bacteria in fetal membranes has not been described...
April 13, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29659246/membrane-nanotubes-increase-the-robustness-of-giant-vesicles
#13
Tripta Bhatia, Jaime Agudo-Canalejo, Rumiana Dimova, Reinhard Lipowsky
Giant unilamellar vesicles (GUVs) provide a direct connection between the nano- and the microregime. On the one hand, these vesicles represent biomimetic compartments with linear dimensions of many micrometers. On the other hand, the vesicle walls are provided by single molecular bilayers that have a thickness of a few nanometers and respond sensitively to molecular interactions with small solutes, biopolymers, and nanoparticles. These nanoscopic responses are amplified by the GUVs and can then be studied on much larger scales...
April 16, 2018: ACS Nano
https://www.readbyqxmd.com/read/29656690/maternal-blood-endotoxin-activity-in-pregnancies-complicated-by-preterm-premature-rupture-of-membranes
#14
Stefania Ronzoni, Rohan D'Souza, Oksana Shynlova, Stephen Lye, Kellie E Murphy
OBJECTIVE: To compare maternal blood endotoxin activity (EA) in women with preterm premature rupture of membranes (PPROM) with gestational age (GA) matched controls; to evaluate serial EA till birth in pPROM and its correlation with latency to delivery. METHODS: We followed singleton preterm pregnancies from admission with PPROM until birth. Uncomplicated, GA-matched pregnancies served as controls. Demographics, birth and neonatal outcomes were collected. EA (EAA™) was assessed serially in PPROM and at study entry in controls...
April 15, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29643791/autologous-transplantation-of-the-internal-limiting-membrane-for-refractory-macular-hole-following-ruptured-retinal-arterial-macroaneurysm-a-case-report
#15
Yumi Iwakawa, Hisanori Imai, Hiromi Kaji, Yuki Mori, Chihiro Ono, Keiko Otsuka, Akiko Miki, Mariko Oishi
Purpose: To report a case of macular hole (MH) secondary to a retinal arterial macroaneurysm (RAMA) which was successfully treated with an autologous transplantation of internal limiting membrane (ILM). Case Report: An 87-year-old female presented with a sudden decrease in central vision in the right eye. A fundus examination revealed a RAMA in the superonasal macular region, a subretinal hemorrhage (SRH), involving the macula, and a sub-ILM hemorrhage. A pars plana vitrectomy (PPV) was performed...
January 2018: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29642747/elevated-maternal-serum-free-%C3%AE-human-chorionic-gonadotropin-%C3%AE-hcg-and-reduced-risk-of-spontaneous-preterm-delivery
#16
Shelly Soni, David A Krantz, Matthew J Blitz, Nidhi Vohra, Burton Rochelson
OBJECTIVE: To evaluate the relationship between first and second trimester maternal serum-free β-hCG and the risk of spontaneous preterm delivery (PTD). STUDY DESIGN: This was a case-control study of women evaluated and delivered at our institution from 2011 to 2015. Spontaneous PTD was defined as delivery before 37 weeks due to spontaneous preterm labor or premature rupture of membranes. Patient with multifetal gestation and those with medically indicated term or PTD were excluded...
April 12, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29642634/bio-based-cellulose-acetate-films-reinforced-with-lignin-and-glycerol
#17
Patricia Gontijo de Melo, Mariana Fornazier Borges, Jéssica Afonso Ferreira, Matheus Vicente Barbosa Silva, Reinaldo Ruggiero
Two sets of four cellulose acetate (degree of substitution = 2.2) were incorporated with lignin extracted from the macaúba endocarp, before and after being chemically modified to sodium carboxymethyl-lignin and aluminum carboxymethyl-lignin, respectively. The eight membranes were prepared by the casting method after dissolution in acetone and embedded with lignins (0.1% w / w ), one without modification (CAc-Lig) and two chemically modified (CAc-CMLNa) and (CAc-CMLAl), compared to membranes of pure acetate (CAc)...
April 10, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29626695/multi-functional-electrospun-antibacterial-core-shell-nanofibrous-membranes-for-prolonged-prevention-of-post-surgical-tendon-adhesion-and-inflammation
#18
K T Shalumon, Chialin Sheu, Chih-Hao Chen, Shih-Heng Chen, Gils Jose, Chang-Yi Kuo, Jyh-Ping Chen
The possibility of endowing an electrospun anti-adhesive barrier membrane with multi-functionality, such as lubrication, prevention of fibroblast attachment and anti-infection and anti-inflammation properties, is highly desirable for the management of post-surgical tendon adhesion. To this end, we fabricated core-shell nanofibrous membranes (CSNMs) with embedded silver nanoparticles (Ag NPs) in the poly(ethylene glycol) (PEG)/poly(caprolactone) (PCL) shell and hyaluronic acid (HA)/ibuprofen in the core. HA imparted a lubrication effect for smooth tendon gliding and reduced fibroblast attachment, while Ag NPs and ibuprofen functioned as anti-infection and anti-inflammation agents, respectively...
April 4, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29617883/risk-for-adverse-pregnancy-outcome-in-axial-spondyloarthritis-and-rheumatoid-arthritis-disease-activity-matters
#19
Astrid Zbinden, Stephanie van den Brandt, Monika Østensen, Peter M Villiger, Frauke Förger
Objective: To analyse pregnancy outcome and delivery mode in patients with RA and axial spondyloarthritis (axSpA) in relation to disease activity and anti-rheumatic drugs. Methods: Patients with RA and axSpA were compared with age-matched healthy controls (HCs) with respect to pregnancy outcome and delivery mode. Disease activity (DAS28, ASDAS, CRP) and medication use of patients was assessed once at each trimester. ORs with 95% CI were calculated with univariate and multivariate regression models...
March 30, 2018: Rheumatology
https://www.readbyqxmd.com/read/29617553/rupture-of-lipid-membranes-induced-by-amphiphilic-janus-nanoparticles
#20
Kwahun Lee, Liuyang Zhang, Yi Yi, Xianqiao Wang, Yan Yu
The surface coatings of nanoparticles determine their interaction with biomembranes, but studies have been limited almost exclusively to nanoparticles with a uniform surface chemistry. Although nanoparticles are increasingly made with complex surface chemistries to achieve multi-functionalities, our understanding of how a heterogeneous surface coating affects particle-biomembrane interaction has been lagging far behind. Here we report an investigation of this question in an experimental system consisting of amphiphilic "two-faced" Janus nanoparticles and supported lipid membranes...
April 4, 2018: ACS Nano
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