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https://www.readbyqxmd.com/read/29666764/evaluation-of-a-therapy-for-idiopathic-chronic-enterocolitis-in-rhesus-macaques-macaca-mulatta-and-linked-microbial-community-correlates
#1
Joshua M Taylor, Erik L Clarke, Kate Baker, Abigail Lauder, Dorothy Kim, Aubrey Bailey, Gary D Wu, Ronald G Collman, Lara Doyle-Meyers, Kasi Russell-Lodrigue, James Blanchard, Frederic D Bushman, Rudolf Bohm
Idiopathic chronic enterocolitis (ICE) is one of the most commonly encountered and difficult to manage diseases of captive rhesus macaques ( Macaca mulatta ). The etiology is not well understood, but perturbations in gut microbial communities have been implicated. Here we evaluated the effects of a 14-day course of vancomycin, neomycin, and fluconazole on animals affected with ICE, comparing treated, untreated, and healthy animals. We performed microbiome analysis on duodenal and colonic mucosal samples and feces in order to probe bacterial and/or fungal taxa potentially associated with ICE...
2018: PeerJ
https://www.readbyqxmd.com/read/29666644/questioning-the-extreme-neurovirulence-of-monkey-b-virus-macacine-alphaherpesvirus-1
#2
REVIEW
R Eberle, L Jones-Engel
Monkey B virus ( Macacine alphaherpesvirus 1; BV) occurs naturally in macaques of the genus Macaca, which includes rhesus and long-tailed (cynomolgus) monkeys that are widely used in biomedical research. BV is closely related to the human herpes simplex viruses (HSV), and BV infections in its natural macaque host are quite similar to HSV infections in humans. Zoonotic BV is extremely rare, having been diagnosed in only a handful of North American facilities with the last documented case occurring in 1998. However, BV is notorious for its neurovirulence since zoonotic infections are serious, usually involving the central nervous system, and are frequently fatal...
2018: Advances in Virology
https://www.readbyqxmd.com/read/29664677/silac-based-quantitative-proteomic-analysis-of-the-livers-of-spontaneous-obese-and-diabetic-rhesus-monkeys
#3
Junlong Wang, Shimeng Xu, Jing Gao, Linqiang Zhang, Zhiguo Zhang, Wenhui Yang, Yunhai Li, Shasha Liao, Hu Zhou, Pingsheng Liu, Bin Liang
Type 2 diabetes mellitus (T2DM) is a severely metabolic disorder that affects above 10% worldwide population. Obesity is a major cause of insulin resistance and contributes to the development of T2DM. Liver is an essential metabolic organ that plays crucial roles in the pathogenesis of obesity and diabetes. However, the underlying mechanisms of liver in the transition of obesity to diabetes are not fully understood. Nonhuman primate (NHP) rhesus monkey is an appropriate animal for research of human diseases...
April 17, 2018: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29663945/silicon-foreign-body-in-the-cerebrum-of-a-rhesus-macaque-macaca-mulatta
#4
Cynthia J Doane, Prisca E Zimmerman, Philip T Putnam, Katalin M Gothard, David G Besselsen
A male rhesus macaque with a cephalic chamber implant for neurophysiology recording presented with hemiparesis affecting the left thoracic and pelvic limbs at approximately 5 wk after craniotomy surgery. MRI indicated a 1×2-cm ovoid cerebrocortical cystic lesion immediately subjacent to the right hemisphere craniotomy and recording chamber. Transdural aspiration of sterile transudate and resultant decompression resolved the hemiparesis, and follow-up MRI at 1 mo indicated resolution of the lesion. Subsequently, necropsy at study end revealed a cerebrocortical foreign body composed of silicon...
April 2, 2018: Comparative Medicine
https://www.readbyqxmd.com/read/29663944/repair-of-a-large-ventral-hernia-in-a-rhesus-macaque-macaca-mulatta-by-using-an-abdominal-component-separation-technique
#5
Steve J Kempton, Jacqueline S Israel, Saverio Capuano Iii, Samuel O Poore
Here we present a 32-y-old rhesus macaque (Macaca mulatta) with a large recurrent ventral incisional hernia. The initial surgery included midline celiotomy for treatment of endometriosis, in which the animal developed a hernia that was repaired with interposition of mesh. Hernia recurrence at 1 y resulted in a defect measuring 7 × 13 cm, with loss of abdominal domain. Skin breakdown was noted with areas of exposed mesh through the skin with associated acute on chronic infection. Clinically, the animal was lethargic, not eating, and failing to thrive...
April 2, 2018: Comparative Medicine
https://www.readbyqxmd.com/read/29663943/retrospective-review-of-surgical-outcomes-and-pair-housing-success-in-vasectomized-rhesus-macaques-macaca-mulatta
#6
Dilrukshi K Ekanayake-Alper, Steven R Wilson, Jodi A Scholz
Providing social housing for adult male macaques can be challenging. One successful strategy for long-term social housing of adult male macaques is to pair them with adult females; however, unwanted breeding must be prevented by sterilization of the male or female. Vasectomy is a simple, highly effective, and minimally invasive method of contraception that is used at our institution to facilitate social housing. We performed a retrospective review to analyze the surgical outcomes and rate of postoperative complications after vasectomy of adult rhesus macaques at our research facility...
April 2, 2018: Comparative Medicine
https://www.readbyqxmd.com/read/29663942/longitudinal-anthropometric-assessment-of-rhesus-macaque-macaca-mulatta-model-of-huntington-disease
#7
Carissa E Hunter, Alvince L Pongos, Tim Y Chi, Christa Payne, Fawn C Stroud, Anthony W S Chan
The neurodegeneration associated with Huntington disease (HD) leads to the onset of motor and cognitive impairment and their advancement with increased age in humans. In children at risk for HD, body measurement growth abnormalities include a reduction in BMI, weight, height, and head circumference. The transgenic HD NHP model was first reported in 2008, and progressive decline in cognitive behaviors and motor impairment have been reported. This study focuses on longitudinal body measurements in HD macaques from infancy through adulthood...
April 2, 2018: Comparative Medicine
https://www.readbyqxmd.com/read/29663353/positron-emission-tomography-imaging-of-cerebral-glucose-metabolism-and-type-1-cannabinoid-receptor-availability-during-temporal-lobe-epileptogenesis-in-the-amygdala-kindling-model-in-rhesus-monkeys
#8
Evy Cleeren, Cindy Casteels, Karolien Goffin, Michel Koole, Koen Van Laere, Peter Janssen, Wim Van Paesschen
OBJECTIVE: We investigated changes in the endocannabinoid system and glucose metabolism during temporal lobe epileptogenesis. METHODS: Because it is rarely possible to study epileptogenesis in humans, we applied the electrical amygdala kindling model in nonhuman primates to image longitudinal changes in type 1 cannabinoid receptor (CB1R) binding and cerebral glucose metabolism. Two rhesus monkeys received [18 F]-MK-9470 and fluorodeoxyglucose-positron emission tomography ([18 F]-FDG -PET) scans in each of the 4 kindling stages to quantify relative changes over time of CB1R binding and cerebral glucose metabolism in vivo...
April 17, 2018: Epilepsia
https://www.readbyqxmd.com/read/29662199/a-single-injection-of-crystallizable-fragment-domain-modified-antibodies-elicits-durable-protection-from-shiv-infection
#9
Rajeev Gautam, Yoshiaki Nishimura, Natalie Gaughan, Anna Gazumyan, Till Schoofs, Alicia Buckler-White, Michael S Seaman, Bruce J Swihart, Dean A Follmann, Michel C Nussenzweig, Malcolm A Martin
In the absence of an effective and safe vaccine against HIV-1, the administration of broadly neutralizing antibodies (bNAbs) represents a logical alternative approach to prevent virus transmission. Here, we introduced two mutations encoding amino acid substitutions (M428L and N434S, collectively referred to as 'LS') into the genes encoding the crystallizable fragment domains of the highly potent HIV-specific 3BNC117 and 10-1074 bNAbs to increase their half-lives and evaluated their efficacy in blocking infection following repeated low-dose mucosal challenges of rhesus macaques (Macaca mulatta) with the tier 2 SHIVAD8-EO ...
April 16, 2018: Nature Medicine
https://www.readbyqxmd.com/read/29658725/i-scan-therefore-i-decline-the-time-course-of-difficulty-monitoring-in-humans-homo-sapiens-and-macaques-macaca-mulatta
#10
J David Smith, Joseph Boomer, Barbara A Church, Alexandria C Zakrzewski, Michael J Beran, Michael L Baum
The study of nonhumans' metacognitive judgments about trial difficulty has grown into an important comparative literature. However, the potential for associative-learning confounds in this area has left room for behaviorist interpretations that are strongly asserted and hotly debated. This article considers how researchers may be able to observe animals' strategic cognitive processes more clearly by creating temporally extended problems within which associative cues are not always immediately available. We asked humans and rhesus macaques to commit to completing spatially extended mazes or to decline completing them through a trial-decline response...
April 16, 2018: Journal of Comparative Psychology
https://www.readbyqxmd.com/read/29657543/association-of-abo-and-rh-blood-groups-with-breast-cancer
#11
Sultan Ayoub Meo, Faryal Suraya, Badar Jamil, Fwziah Al Rouq, Anusha Sultan Meo, Kamran Sattar, Mohammad Javed Ansari, Saleh A Alasiri
Objectives: The aim of this study was to determine the association of "ABO" and "Rhesus" blood groups with incidence of breast cancer. Methods: In this study, we identified 70 research documents from data based search engines including "PubMed", "ISI-Web of Knowledge", "Embase" and "Google Scholar". The research papers were selected by using the primary key-terms including "ABO blood type", "Rhesus" blood type and "breast cancer"...
November 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/29656685/maternal-hepatitis-c-hcv-infection-and-anti-d-immunoglobulin-therapy-study-testing-antibodies-rna-and-genotype-of-hcv-in-baghdad
#12
Waqar Al-Kubaisy, Suzanna Daud, Mustafa Waseem Al-Kubaisi, Omar Waseem Al-Kubaisi, Nik Nairan Abdullah
INTRODUCTION: Hepatitis C virus (HCV) infection is a serious health problem. It is a major contributor to end-stage liver disease. Worldwide, 1-8% of all pregnant women were infected. Women with viral hepatitis may be at an increased risk of pregnancy complications. There are several obstetrics intervention act as risk factors which are specific to women pertaining the HCV infection; anti-D immunoglobulin (Ig) therapy may be one of them. Our objectives were to estimate the prevalence of HCV antibodies (anti-HCV), RNA, and genotype distribution among women with anti-D Ig therapy...
April 15, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29651274/identification-of-unequally-represented-founder-viruses-among-tissues-in-very-early-siv-rectal-transmission
#13
Jian Chen, Yanqin Ren, Lance Daharsh, Lu Liu, Guobin Kang, Qingsheng Li, Qiang Wei, Yanmin Wan, Jianqing Xu
Characterizing the transmitted/founder (T/F) viruses of multi-variant SIV infection may shed new light on the understanding of mucosal transmission. We intrarectally inoculated six Chinese rhesus macaques with a single high dose of SIVmac251 (3.1 × 104 TCID50 ) and obtained 985 full-length env sequences from multiple tissues at 6 and 10 days post-infection by single genome amplification (SGA). All 6 monkeys were infected with a range of 2 to 8 T/F viruses and the dominant variants from the inoculum were still dominant in different tissues from each monkey...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29651156/efficient-differentiation-of-cardiomyocytes-and-generation-of-calcium-sensor-reporter-lines-from-nonhuman-primate-ipscs
#14
Yongshun Lin, Huimin Liu, Michael Klein, John Ostrominski, So Gun Hong, Ravi Chandra Yada, Guibin Chen, Keron Navarengom, Robin Schwartzbeck, Hong San, Zu-Xi Yu, Chengyu Liu, Kaari Linask, Jeanette Beers, Lugui Qiu, Cynthia E Dunbar, Manfred Boehm, Jizhong Zou
Nonhuman primate (NHP) models are more predictive than rodent models for developing induced pluripotent stem cell (iPSC)-based cell therapy, but robust and reproducible NHP iPSC-cardiomyocyte differentiation protocols are lacking for cardiomyopathies research. We developed a method to differentiate integration-free rhesus macaque iPSCs (RhiPSCs) into cardiomyocytes with >85% purity in 10 days, using fully chemically defined conditions. To enable visualization of intracellular calcium flux in beating cardiomyocytes, we used CRISPR/Cas9 to stably knock-in genetically encoded calcium indicators at the rhesus AAVS1 safe harbor locus...
April 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29649257/an-experimental-staphylococcus-aureus-carriage-and-decolonization-model-in-rhesus-macaques-macaca-mulatta
#15
Bibi C G C Slingerland, Merei Keehnen, Boudewijn Ouwerling, Mehri Tavakol, Susan V Snijders, Henri A Verbrugh, Margreet C Vos, Edmond J Remarque, Jan A M Langermans, Willem J B van Wamel
Our human model of nasal colonization and eradication of S. aureus is limited by safety issues. As rhesus macaques are closely related to humans and natural hosts for S. aureus, we developed an experimental decolonization and inoculation protocol in these animals. Animals were screened for nasal carriage of S. aureus and 20 carriers were selected. Decolonization was attempted using nasal mupirocin (10 animals) or mupirocin plus trimethoprim/sulfadiazine intramuscularly (10 animals) both once daily for 5 days, and checked by follow-up cultures for 10 weeks...
2018: PloS One
https://www.readbyqxmd.com/read/29643246/the-dynamics-of-siv-2-ltr-circles-in-the-presence-and-absence-of-cd8-cells
#16
Benjamin B Policicchio, Erwing Fabian Cardozo, Paola Sette, Cuiling Xu, George Haret-Richter, Tammy Dunsmore, Cristian Apetrei, Ivona Pandrea, Ruy M Ribeiro
CD8+ cells play a key role in HIV/SIV infection, but their specific mechanism(s) of action in controlling the virus are unclear. 2-LTR circles are extrachromosomal products generated upon failed integration of HIV/SIV. To understand the specific effects of CD8+ cells on infected cells, we analyzed the dynamics of 2-LTR circles in SIVmac251-infected rhesus macaques (RM) treated with an integrase inhibitor (INT). Twenty RMs underwent CD8+ cell depletion, received RAL monotherapy or a combination of both. Blood, lymph nodes (LNs) and gut biopsies were routinely sampled...
April 11, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29626484/neuroestradiol-in-regulation-of-gnrh-release
#17
REVIEW
Ei Terasawa
The concept that the positive feedback effect of ovarian estradiol (E2 ) results in GnRH and gonadotropin surges is a well-established principle. However, a series of studies investigating the rapid action of E2 in female rhesus monkeys has led to a new concept that neuroestradiol, synthesized and released in the hypothalamus, also contributes to regulation of the preovulatory GnRH surge. This unexpected finding started from our surprising observation that E2 induces rapid stimulatory action in GnRH neurons in vitro...
April 4, 2018: Hormones and Behavior
https://www.readbyqxmd.com/read/29625461/allogeneic-ipsc-derived-rpe-cell-graft-failure-following-transplantation-into-the-subretinal-space-in-nonhuman-primates
#18
Trevor J McGill, Jonathan Stoddard, Lauren M Renner, Ilhem Messaoudi, Kapil Bharti, Shoukhrat Mitalipov, Andreas Lauer, David J Wilson, Martha Neuringer
Purpose: To characterize the intraocular immune response following transplantation of iPS-derived allogeneic RPE cells into the subretinal space of non-immune-suppressed rhesus macaques. Methods: GFP-labeled allogeneic iPS-derived RPE cells were transplanted into the subretinal space of one eye (n = 6), and into the contralateral eye 1 day to 4 weeks later, using a two-stage transretinal and transscleral approach. Retinas were examined pre- and post-surgery by color fundus photography, fundus autofluorescence, and optical coherence tomography (OCT) imaging...
March 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29622929/is-male-rhesus-macaque-facial-coloration-under-intrasexual-selection
#19
Megan Petersdorf, Constance Dubuc, Alexander V Georgiev, Sandra Winters, James P Higham
Exaggerated male traits can evolve under intra- or intersexual selection, but it remains less clear how often both mechanisms act together on trait evolution. While the males of many anthropoid primate species exhibit colorful signals that appear to be badges of status under intrasexual selection, the red facial coloration of male rhesus macaques ( Macaca mulatta ) appears to have evolved primarily under intersexual selection and female mate choice. Nonetheless, experiments show that red color is salient to males, raising the question of whether the signal may also be under intrasexual selection...
November 2017: Behavioral Ecology: Official Journal of the International Society for Behavioral Ecology
https://www.readbyqxmd.com/read/29618650/siv-mac239-vif-and-human-apobec3b-interactions-resemble-those-between-hiv-1-vif-and-human-apobec3g
#20
Jiayi Wang, Nadine M Shaban, Allison M Land, William L Brown, Reuben S Harris
Several members of the APOBEC3 DNA cytosine deaminase family can potently inhibit Vif-deficient HIV-1 by catalyzing cytosine deamination in viral cDNA and impeding reverse transcription. HIV-1 counteracts restriction with the virally encoded Vif protein, which targets relevant APOBEC3 proteins for proteasomal degradation. HIV-1 Vif is optimized for degrading the restrictive human APOBEC3 repertoire and, in general, lentiviral Vif proteins specifically target the restricting APOBEC3 enzymes of each host species...
April 4, 2018: Journal of Virology
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