keyword
MENU ▼
Read by QxMD icon Read
search

rhesus

keyword
https://www.readbyqxmd.com/read/29452398/predominant-patterns-of-splicing-evolution-on-human-chimpanzee-and-macaque-evolutionary-lineages
#1
Jieyi Xiong, Jiang Xi, Angeliki Ditsiou, Yang Gao, Jing Sun, Elijah D Lowenstein, Shuyun Huang, Philipp Khaitovich
Although splicing is widespread and evolves rapidly among species, the mechanisms driving this evolution, as well as its functional implications, are not yet fully understood. We analyzed the evolution of splicing patterns based on transcriptome data from five tissues of humans, chimpanzees, rhesus macaques, and mice. In total, 1,526 exons and exon sets from 1,236 genes showed significant splicing differences among primates. More than 60% of these differences represent constitutive-to-alternative exon transitions while an additional 25% represent changes in exon inclusion frequency...
February 14, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29447591/characterization-of-a-partial-body-irradiation-model-with-oral-cavity-shielding-in-non-human-primates
#2
Michael V Accardi, Oreola Donini, Adam Rumage, Alexis Ascah, Julius Haruna, Mylène Pouliot, Kim Bujold, Hai Haung, Wieslaw Wierzbicki, John Stamatopoulos, Houman Naraghi, Thomas Measey, Simon Authier
PURPOSE: Characterization of a novel partial body irradiation (PBI) shielding strategy in nonhuman primates (NHP; rhesus macaques), aimed at protecting the oral cavity, with respect to various gastrointestinal (GI-ARS) syndrome parameters as well as buccal ulceration development. MATERIALS AND METHODS: NHPs were irradiated using a Cobalt-60 gamma source, in a single uniform dose, ranging from 9-13 Gy and delivered at 0.60-0.80 Gy min -1 . Animals were either partially shielded via oral cavity shielding (PBI OS ) or underwent total body irradiation (TBI)...
February 15, 2018: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/29447046/oral-curcumin-supplementation-improves-fine-motor-function-in-the-middle-aged-rhesus-monkey
#3
Tara L Moore, Bethany G E Bowley, Penny L Shultz, Samantha M Calderazzo, Eli J Shobin, Ajay R Uprety, Douglas L Rosene, Mark B Moss
Aged individuals experience decreased fine motor function of the hand and digits, which could result, in part, from the chronic, systemic state of inflammation that occurs with aging. Recent research for treating age-related inflammation has focused on the effects of nutraceuticals that have anti-inflammatory properties. One particular dietary polyphenol, curcumin, the principal curcuminoid of the spice turmeric, has been shown to have significant anti-inflammatory effects and there is mounting evidence that curcumin may serve to reduce systemic inflammation...
February 15, 2018: Somatosensory & Motor Research
https://www.readbyqxmd.com/read/29445153/development-of-a-chimeric-zika-vaccine-using-a-licensed-live-attenuated-flavivirus-vaccine-as-backbone
#4
Xiao-Feng Li, Hao-Long Dong, Hong-Jiang Wang, Xing-Yao Huang, Ye-Feng Qiu, Xue Ji, Qing Ye, Chunfeng Li, Yang Liu, Yong-Qiang Deng, Tao Jiang, Gong Cheng, Fu-Chun Zhang, Andrew D Davidson, Ya-Jun Song, Pei-Yong Shi, Cheng-Feng Qin
The global spread of Zika virus (ZIKV) and its unexpected association with congenital defects necessitates the rapid development of a safe and effective vaccine. Here we report the development and characterization of a recombinant chimeric ZIKV vaccine candidate (termed ChinZIKV) that expresses the prM-E proteins of ZIKV using the licensed Japanese encephalitis live-attenuated vaccine SA14-14-2 as the genetic backbone. ChinZIKV retains its replication activity and genetic stability in vitro, while exhibiting an attenuation phenotype in multiple animal models...
February 14, 2018: Nature Communications
https://www.readbyqxmd.com/read/29441679/abo-and-rh-blood-group-genotypes-in-a-cohort-of-saudi-stem-cell-donors
#5
M Alzahrani, D Jawdat, A Alaskar, N Cereb, A H Hajeer
The ABO and rhesus (Rh) blood group antigens are the most frequently studied genetic markers in a large group of people. Blood type frequencies vary in different racial/ethnic groups. Our objective was to investigate the distribution of the ABO and rhesus (Rh) blood groups by molecular typing method in a population of Saudi stem cell donors. Our data indicate that the most common blood group in our population is group O followed by group A then group B, and finally, the least common is group AB.
February 13, 2018: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/29438809/flow-visualization-through-particle-image-velocimetry-in-realistic-model-of-rhesus-monkey-s-upper-airway
#6
Ji-Woong Kim, Nguyen Lu Phuong, Shin-Ichiro Aramaki, Kazuhide Ito
Studies concerning inhalation toxicology and respiratory drug-delivery systems require biological testing involving experiments performed on animals. Particle image velocimetry (PIV) is an effective in vitro technique that reveals detailed inhalation flow patterns, thereby assisting analyses of inhalation exposure to various substances. A realistic model of a rhesus-monkey upper airway was developed to investigate flow patterns in its oral and nasal cavities through PIV experiments performed under steady-state constant inhalation conditions at various flow rates-4, 10, and 20 L/min...
February 10, 2018: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/29436793/gonadotropin-regulation-of-retinoic-acid-activity-in-the-testis
#7
Seyedmehdi Nourashrafeddin, Batool Hosseini Rashidi
Initiation of spermatogenesis in primates is triggered at puberty by an increase in gonadotropins; i.e., follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Prior to puberty, testis of the monkey contains only undifferentiated germ cells. However, sermatogonial differentiation and spermatogenesis may be initiated prior to puberty after stimulation with exogenous LH and FSH. Retinoic acid (RA) signaling is considered to be a major component that drives spermatogonial differentiation. We were interested in evaluating the relative role of LH and FSH, either alone or in combination, in regulating the retinoic acid signaling in monkey testis...
January 2018: Acta Medica Iranica
https://www.readbyqxmd.com/read/29435829/an-siv-macaque-model-of-siv-and-hand-the-need-for-adjunctive-therapies-in-hiv-that-target-activated-monocytes-and-macrophages
#8
REVIEW
Jaclyn Mallard, Kenneth Williams
Non-human primate models of AIDS and neuroAIDS are critical to study HIV infection of the CNS, neuropathology, and immune activation and macrophage accumulation that occurs in HAND. SIV, similar to HIV, infects CD4+ T lymphocytes and monocytes/macrophages. Virus enters the CNS early, and macrophage activation correlates with CNS disease, as well as inflammation outside of the CNS. Antiretroviral in HIV+ humans and SIV+ Rhesus macaques results in non-detectable plasma virus, decreased or non-detectable viral RNA or protein in the CNS...
February 12, 2018: Journal of Neurovirology
https://www.readbyqxmd.com/read/29435770/visual-artificial-grammar-learning-by-rhesus-macaques-macaca-mulatta-exploring-the-role-of-grammar-complexity-and-sequence-length
#9
Lisa A Heimbauer, Christopher M Conway, Morten H Christiansen, Michael J Beran, Michael J Owren
Humans and nonhuman primates can learn about the organization of stimuli in the environment using implicit sequential pattern learning capabilities. However, most previous artificial grammar learning studies with nonhuman primates have involved relatively simple grammars and short input sequences. The goal in the current experiments was to assess the learning capabilities of monkeys on an artificial grammar-learning task that was more complex than most others previously used with nonhumans. Three experiments were conducted using a joystick-based, symmetrical-response serial reaction time task in which two monkeys were exposed to grammar-generated sequences at sequence lengths of four in Experiment 1, six in Experiment 2, and eight in Experiment 3...
February 12, 2018: Animal Cognition
https://www.readbyqxmd.com/read/29432794/different-macaque-models-of-cognitive-aging-exhibit-task-dependent-behavioral-disparities
#10
Alison E Comrie, Daniel T Gray, Anne C Smith, Carol A Barnes
Deficits in cognitive functions that rely on the integrity of the frontal and temporal lobes are characteristic of normative human aging. Due to similar aging phenotypes and homologous cortical organization between nonhuman primates and humans, several species of macaque monkeys are used as models to explore brain senescence. These macaque species are typically regarded as equivalent models of cognitive aging, yet no direct comparisons have been made to support this assumption. Here we used adult and aged rhesus and bonnet macaques (Macaca mulatta and Macaca radiata) to characterize the effect of age on acquisition and retention of information across delays in a battery of behavioral tasks that rely on prefrontal cortex and medial temporal lobe networks...
February 9, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29432596/high-turnover-of-tissue-macrophages-contributes-to-tuberculosis-reactivation-in-simian-immunodeficiency-virus-infected-rhesus-macaques
#11
Marcelo J Kuroda, Chie Sugimoto, Yanhui Cai, Kristen M Merino, Smriti Mehra, Mariluz Araínga, Chad J Roy, Cecily C Midkiff, Xavier Alvarez, Elizabeth S Didier, Deepak Kaushal
Background: Tuberculosis (TB) and human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS) profoundly affect the immune system and synergistically accelerate disease progression. It is believed that CD4+ T-cell depletion by HIV is the major cause of immunodeficiency and reactivation of latent TB. Previous studies demonstrated that blood monocyte turnover concurrent with tissue macrophage death from virus infection better predicted AIDS onset than CD4+ T-cell depletion in macaques infected with simian immunodeficiency virus (SIV)...
February 8, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29432452/a-conserved-eph-family-receptor-binding-motif-on-the-gh-gl-complex-of-kaposi-s-sarcoma-associated-herpesvirus-and-rhesus-monkey-rhadinovirus
#12
Anna K Großkopf, Armin Ensser, Frank Neipel, Doris Jungnickl, Sarah Schlagowski, Ronald C Desrosiers, Alexander S Hahn
Kaposi's sarcoma-associated herpesvirus (KSHV) is a human oncogenic virus associated with Kaposi's sarcoma and two B-cell malignancies. The rhesus monkey rhadinovirus (RRV) is a virus of nonhuman primates that is closely related to KSHV. Eph family receptor tyrosine kinases (Ephs) are cellular receptors for the gH/gL glycoprotein complexes of both KSHV and RRV. Through sequence analysis and mutational screens, we identified conserved residues in the N-terminal domain of KSHV and RRV glycoprotein H that are critical for Eph-binding in vitro...
February 12, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29432451/microexon-gene-transcriptional-profiles-and-evolution-provide-insights-into-blood-processing-by-the-schistosoma-japonicum-esophagus
#13
Xiao-Hong Li, Ricardo DeMarco, Leandro X Neves, Sally R James, Katherine Newling, Peter D Ashton, Jian-Ping Cao, R Alan Wilson, William Castro-Borges
BACKGROUND: Adult schistosomes have a well-developed alimentary tract comprising an oral sucker around the mouth, a short esophagus and a blind ending gut. The esophagus is not simply a muscular tube for conducting blood from the mouth to gut but is divided into compartments, surrounded by anterior and posterior glands, where processing of ingested blood is initiated. Self-cure of rhesus macaques from a Schistosoma japonicum infection appears to operate by blocking the secretory functions of these glands so that the worms cease feeding and slowly starve to death...
February 12, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29432117/closed-loop-continuous-hand-control-via-chronic-recording-of-regenerative-peripheral-nerve-interfaces
#14
Philip P Vu, Zachary T Irwin, Autumn J Bullard, Shoshana W Ambani, Ian C Sando, Melanie G Urbanchek, Paul S Cederna, Cynthia A Chestek
Loss of the upper limb imposes a devastating interruption to everyday life. Full restoration of natural arm control requires the ability to simultaneously control multiple degrees of freedom of the prosthetic arm and maintain that control over an extended period of time. Current clinically available myoelectric prostheses do not provide simultaneous control or consistency for transradial amputees. To address this issue, we have implemented a standard Kalman filter for continuous hand control using intramuscular electromyography (EMG) from both regenerative peripheral nerve interfaces (RPNI) and an intact muscle within non-human primates...
February 2018: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/29431892/correlates-of-economic-decisions-in-the-dorsal-and-subgenual-anterior-cingulate-cortices
#15
Habiba Azab, Benjamin Y Hayden
The anterior cingulate cortex can be divided into distinct ventral (subgenual, sgACC) and dorsal (dACC), portions. The role of dACC in value-based decision-making is hotly debated, while the role of sgACC is poorly understood. We recorded neuronal activity in both regions in rhesus macaques performing a token-gambling task. We find that both encode many of the same variables; including integrated offered values of gambles, primary as well as secondary reward outcomes, number of current tokens, and anticipated rewards...
February 12, 2018: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29428284/cell-free-dna-screening-for-single-gene-disorders-and-determination-of-fetal-rhesus-d-genotype
#16
REVIEW
Kristin D Gerson, Barbara M O'Brien
The use of cell-free DNA (cfDNA) for screening and diagnosis of single-gene disorders is an evolving technology, and its application at this time is limited. Invasive testing is currently recommended for the diagnosis of single-gene disorders. The limitations of cfDNA technology are most notable in clinical settings involving X-linked and autosomal recessive conditions, in part because maternal mutant alleles greatly outnumber those of fetal origin. Examples of single-gene disorders for which cfDNA has been used include skeletal dyplasias, cystic fibrosis, congenital adrenal hyperplasia, β-thalassemia, and muscular dystrophies...
March 2018: Obstetrics and Gynecology Clinics of North America
https://www.readbyqxmd.com/read/29426955/uncoupling-the-widespread-occurrence-of-anti-nmdar1-autoantibodies-from-neuropsychiatric-disease-in-a-novel-autoimmune-model
#17
Hong Pan, Bárbara Oliveira, Gesine Saher, Ekrem Dere, Daniel Tapken, Marina Mitjans, Jan Seidel, Janina Wesolowski, Debia Wakhloo, Christina Klein-Schmidt, Anja Ronnenberg, Kerstin Schwabe, Ralf Trippe, Kerstin Mätz-Rensing, Stefan Berghoff, Yazeed Al-Krinawe, Henrik Martens, Martin Begemann, Winfried Stöcker, Franz-Josef Kaup, Reinhard Mischke, Susann Boretius, Klaus-Armin Nave, Joachim K Krauss, Michael Hollmann, Fred Lühder, Hannelore Ehrenreich
Autoantibodies of the IgG class against N-methyl-D-aspartate-receptor subunit-NR1 (NMDAR1-AB) were considered pathognomonic for anti-NMDAR encephalitis. This view has been challenged by the age-dependent seroprevalence (up to >20%) of functional NMDAR1-AB of all immunoglobulin classes found in >5000 individuals, healthy or affected by different diseases. These findings question a merely encephalitogenic role of NMDAR1-AB. Here, we show that NMDAR1-AB belong to the normal autoimmune repertoire of dogs, cats, rats, mice, baboons, and rhesus macaques, and are functional in the NMDAR1 internalization assay based on human IPSC-derived cortical neurons...
February 9, 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29423731/hiv-persistence-in-adipose-tissue-reservoirs
#18
REVIEW
Jacob Couturier, Dorothy E Lewis
PURPOSE OF REVIEW: The purpose of this review is to examine the evidence describing adipose tissue as a reservoir for HIV-1 and how this often expansive anatomic compartment contributes to HIV persistence. RECENT FINDINGS: Memory CD4 T cells and macrophages, the major host cells for HIV, accumulate in adipose tissue during HIV/SIV infection of humans and rhesus macaques. Whereas HIV and SIV proviral DNA is detectable in CD4 T cells of multiple fat depots in virtually all infected humans and monkeys examined, viral RNA is less frequently detected, and infected macrophages may be less prevalent in adipose tissue...
February 9, 2018: Current HIV/AIDS Reports
https://www.readbyqxmd.com/read/29423458/posterior-ciliary-artery-occlusion
#19
Sohan Singh Hayreh
Objective: To compare the severity of ischemic damage following posterior ciliary artery (PCA) occlusion in old, atherosclerotic, hypertensive monkeys to that in young monkeys. Design: Experimental study. Subjects: Seven eyes of normal, healthy rhesus monkeys and 8 of old, atherosclerotic, hypertensive monkeys. Methods: By lateral orbitotomy, all PCAs were cut behind the eyeball in both groups of animals. The fundus and the optic disc were evaluated by repeated ophthalmoscopy, color fundus photography and fluorescein fundus angiography, before and immediately after cutting the PCAs and serially thereafter during the follow-up period...
February 2018: Ophthalmology Retina
https://www.readbyqxmd.com/read/29422700/a-cross-species-comparison-of-abnormal-behavior-in-three-species-of-singly-housed-old-world-monkeys
#20
Corrine K Lutz
Abnormal behavior occurs in a number of captive nonhuman primate species and is often used as an indicator of welfare. However, reported levels of abnormal behavior often vary across species, making general welfare judgments difficult. The purpose of this study was to assess differences in levels of abnormal behavior and associated risk factors across three species of Old World monkeys in order to identify similarities and differences across species. The subjects were 415 (109 females) cynomolgus macaques (Macaca fascicularis), 365 (181 females) rhesus macaques (Macaca mulatta), and 331 (187 females) baboons (Papio hamadryas) that had been singly-housed for 30-120 days...
February 2018: Applied Animal Behaviour Science
keyword
keyword
54036
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"