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https://www.readbyqxmd.com/read/28823132/a-short-term-supranutritional-vitamin-e-supplementation-alleviated-respiratory-alkalosis-but-did-not-reduce-oxidative-stress-in-heat-stressed-pigs
#1
Fan Liu, Pietro Celi, Surinder Singh Chauhan, Jeremy James Cottrell, Brian Joseph Leury, Frank Rowland Dunshea
Objective: Heat stress (HS) triggers oxidative stress and respiratory alkalosis in pigs. The objective of this experiment was to study whether a short-term supranutritional amount of dietary vitamin E (VE) can mitigate oxidative stress and respiratory alkalosis in heat-stressed pigs. Methods: A total of 24 pigs were given either a control diet (17 IU/kg VE) or a high VE (200 IU/kg VE; HiVE) diet for 14 d, then exposed to thermoneutral (TN; 20°C, 45% humidity) or HS (35°C, 35-45% humidity, 8 h daily) conditions for 7 d...
August 16, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28823101/predictors-of-disordered-eating-in-young-males
#2
R Doumit, J Abi Kharma, M J Sanchez-Ruiz, N Zeeni
Recent findings suggest that disordered eating (DE) symptomatology may be underestimated in the male population. The present study examined depressive symptomatology as a potential mediator of the relationships between body image dissatisfaction, strategies to change body weight and muscles, media pressure, and DE (emotional, restrained and emotional eating) in 260 male undergraduates who completed a self-reported questionnaire. Path analyses indicated that media influence and strategies to decrease body weight had direct positive effects on depressive symptomatology, which in turn predicted emotional eating...
August 19, 2017: Community Mental Health Journal
https://www.readbyqxmd.com/read/28823079/mechanobiological-model-of-arterial-growth-and-remodeling
#3
Maziyar Keshavarzian, Clark A Meyer, Heather N Hayenga
A coupled agent-based model (ABM) and finite element analysis (FEA) computational framework is developed to study the interplay of bio-chemo-mechanical factors in blood vessels and their role in maintaining homeostasis. The agent-based model implements the power of REPAST Simphony libraries and adapts its environment for biological simulations. Coupling a continuum-level model (FEA) to a cellular-level model (ABM) has enabled this computational framework to capture the response of blood vessels to increased or decreased levels of growth factors, proteases and other signaling molecules (on the micro scale) as well as altered blood pressure...
August 19, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28823016/de-novo-synthesis-of-linoleic-acid-in-multiple-collembola-species
#4
Miriama Malcicka, Joachim Ruther, Jacintha Ellers
Many ecological interactions in communities take place between consumers and the organisms they feed on. Continuous surplus of specific nutritional compounds in the diet may lead to evolutionary changes in the metabolic capacity of the consumer, leaving the biosynthesis of such compounds prone to genetic decay and render organisms auxotrophic. A nutrient that is essential to many organisms is the unsaturated fatty acid, linoleic acid (LA; 18:2n-6), which is important in the maintenance of cell membrane fluidity and as a precursor for signaling molecules...
August 19, 2017: Journal of Chemical Ecology
https://www.readbyqxmd.com/read/28823009/proton-pump-inhibitors-as-risk-factor-for-metabolic-syndrome-and-hepatic-steatosis-in-coeliac-disease-patients-on-gluten-free-diet
#5
Nicola Imperatore, Raffaella Tortora, Testa Anna, Nicolò Gerbino, Nicola Caporaso, Antonio Rispo
BACKGROUND: Recent research has shown that patients with coeliac disease (CD) are at risk of developing metabolic syndrome (MS) and hepatic steatosis (HS) after commencing a gluten-free diet (GFD). This study aimed to evaluate the predictive factors for MS and HS in CD after 1 year of GFD. METHODS: All consecutive newly diagnosed CD patients were enrolled. We prospectively collected data about BMI; waist circumference; blood pressure; cholesterol; triglycerides, glucose and insulin blood levels; insulin resistance (through the homeostatic model assessment HOMA-IR) and treatment with proton pump inhibitors (PPI)...
August 19, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28822967/temporal-dynamics-of-cardiac-hypertrophic-growth-in-response-to-pressure-overload
#6
Yuan Wang, Yuannyu Zhang, Guanqiao Ding, Herman May, Jian Xu, Thomas G Gillette, Hang Wang, Zhao V Wang
Hypertension is one of the most important risk factors of heart failure. In response to high blood pressure, the left ventricle manifests hypertrophic growth to ameliorate wall stress, which may progress into decompensation and trigger pathological cardiac remodeling. Despite the clinical importance, the temporal dynamics of pathological cardiac growth remains elusive. Here, we took advantage of the puromycin labeling approach to measure the relative rates of protein synthesis as a way to delineate the temporal regulation of cardiac hypertrophic growth...
August 19, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28822962/glucose-transporter-4-glut4-deficient-hearts-develop-maladaptive-hypertrophy-in-response-to-physiologic-or-pathologic-stresses
#7
Adam Raymond Wende, Jaetaek Kim, William Holland, Benjamin E Wayment, Brian T O'Neill, Joseph Tuinei, Manoja K Brahma, Mark E Pepin, Mark A McCrory, Ivan Luptak, Ganesh V Halade, Sheldon E Litwin, E Dale Abel
Pathological cardiac hypertrophy may be associated with reduced expression of the GLUT4 glucose transporter in contrast to exercise-induced cardiac hypertrophy, where GLUT4 levels are increased. However, mice with cardiac specific deletion of GLUT4 (G4H-/-) have normal cardiac function in the unstressed state. This study tested the hypothesis that cardiac GLUT4 is required for myocardial adaptations to hemodynamic demands. G4H-/- and control littermates (Con) were subjected to either a pathological model of left ventricular pressure overload (transverse aortic constriction; TAC) or a physiological model of endurance exercise (swim training)...
August 19, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28822959/na2s-a-fast-releasing-h2s-donor-given-as-suppository-lowers-blood-pressure-in-rats
#8
Lenka Tomasova, Adrian Drapala, Halina Jurkowska, Maria Wróbel, Marcin Ufnal
BACKGROUND: Hydrogen sulfide (H2S) is involved in blood pressure control. The available slow-releasing H2S-donors are poorly soluble in water and their ability to release H2S in biologically relevant amounts under physiological conditions is questionable. Therefore, new slow-releasing donors or new experimental approaches to fast-releasing H2S donors are needed. METHODS: Hemodynamics and ECG were recorded in male, anesthetized Wistar Kyoto rats (WKY) and in Spontaneously hypertensive rats (SHR) at baseline and after: 1) intravenous (iv) infusion of vehicle or Na2S; 2) administration of vehicle suppositories or Na2S suppositories...
April 19, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28822899/a-coupled-diffusion-fluid-pressure-model-to-predict-cell-density-distribution-for-cells-encapsulated-in-a-porous-hydrogel-scaffold-under-mechanical-loading
#9
Feihu Zhao, Ted J Vaughan, Myles J Mc Garrigle, Laoise M McNamara
Tissue formation within tissue engineering (TE) scaffolds is preceded by growth of the cells throughout the scaffold volume and attachment of cells to the scaffold substrate. It is known that mechanical stimulation, in the form of fluid perfusion or mechanical strain, enhances cell differentiation and overall tissue formation. However, due to the complex multi-physics environment of cells within TE scaffolds, cell transport under mechanical stimulation is not fully understood. Therefore, in this study, we have developed a coupled multiphysics model to predict cell density distribution in a TE scaffold...
August 3, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28822828/targeted-lowering-of-central-blood-pressure-in-patients-with-hypertension-baseline-recruitment-rationale-and-design-of-a-randomized-controlled-trial-the-low-cbp-study
#10
James E Sharman, Tony Stanton, Christopher M Reid, Anthony Keech, Philip Roberts-Thomson, Simon Stewart, Robert Greenough, Michael Stowasser, Walter P Abhayaratna
BACKGROUND: High blood pressure (BP) is the most common modifiable cause of death from cardiovascular disease. Lowering BP with medication improves patient outcomes, but even in populations with normal upper arm (brachial) BP there remains considerable residual risk for cardiovascular disease and this may be due to persistently elevated central BP. There has never been a trial to determine the value of targeted central BP lowering among patients with hypertension, and this was the aim of this study...
August 16, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28822815/enrichment-of-highly-settleable-microalgal-consortia-in-mixed-cultures-for-effluent-polishing-and-low-cost-biomass-production
#11
Yuansheng Hu, Xiaodi Hao, Mark van Loosdrecht, Huiqin Chen
Microalgae cultivation is a promising technology for integrated effluent polishing and biofuel production, but poor separability of microalgal cells hinders its industrial application. This study intended to selectively enrich settleable microalgal consortia in mixed culture by applying "wash-out" pressure, which was realized by controlling settling time (ST) and volume exchange ratio (VER) in photo-SBRs. The results demonstrated that highly settleable microalgal consortia (settling efficiency>97%; SVI = 17-50 mL/g) could be enriched from indigenous algal cultures developed in WWTP's effluent...
August 15, 2017: Water Research
https://www.readbyqxmd.com/read/28822809/inhibition-of-soluble-epoxide-hydrolase-lowers-portal-hypertension-in-cirrhotic-rats-by-ameliorating-endothelial-dysfunction-and-liver-fibrosis
#12
Wensheng Deng, Yiming Zhu, Jiayun Lin, Lei Zheng, Chihao Zhang, Meng Luo
Epoxyeicostrienoic acids (EETs) are arachidonic acid derived meditators which are catalyzed by soluble epoxide hydrolase (sEH) to less active dihydroeicostrienoics acids (DHETS). The aim of our study is to investigate the effects of sEH inhibition on hepatic and systemic hemodynamics, hepatic endothelial dysfunction, and hepatic fibrosis in CCl4 cirrhotic rats. The sEH inhibitor,trans-4-{4-[3-(4-trifluoromethoxyphenyl)-ureido]cyclohexyloxy}benzoic acid (t-TUCB) was administered to stabilize hepatic EETs by gavage at a dose of 1mg/kg/d...
August 16, 2017: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/28822805/mg53-is-dispensable-for-t-tubule-maturation-but-critical-for-maintaining-t-tubule-integrity-following-cardiac-stress
#13
Caimei Zhang, Biyi Chen, Yihui Wang, Ang Guo, Yiqun Tang, Tahsin Khataei, Yun Shi, William J Kutschke, Kathy Zimmerman, Robert M Weiss, Jie Liu, Christopher J Benson, Jiang Hong, Jianjie Ma, Long-Sheng Song
The cardiac transverse (T)-tubule membrane system is the safeguard for cardiac function and undergoes dramatic remodeling in response to cardiac stress. However, the mechanism by which cardiomyocytes repair damaged T-tubule network remains unclear. In the present study, we tested the hypothesis that MG53, a muscle-specific membrane repair protein, antagonizes T-tubule damage to protect against maladaptive remodeling and thereby loss of excitation-contraction coupling and cardiac function. Using MG53-knockout (MG53-KO) mice, we first established that deficiency of MG53 had no impact on maturation of the T-tubule network in developing hearts...
August 16, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/28822777/managing-the-course-of-diabetic-kidney-disease-from-the-old-to-the-new
#14
REVIEW
Ronald M Goldenberg, Murray Berall, Christopher T M Chan, David Z I Cherney, Julie A Lovshin, Philip A McFarlane, Peter A Senior, Subodh Verma, Jordan J Weinstein
Diabetic kidney disease (DKD) is a group of chronic kidney diseases that is associated with significant cardiovascular as well as all-cause morbidity and mortality. Although DKD is often progressive in nature, its evolution can be modified by intensive management of glycemia and blood pressure and inhibition of the renin-angiotensin-aldosterone system. This review provides an overview of how multifactorial interventions can provide renal protection and includes a discussion of the nonglycemic effects of incretin-based diabetes therapies (glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase 4 inhibitors) and sodium-glucose cotransporter-2 inhibitors within the kidney in patients with type 2 diabetes...
August 16, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28822739/experimental-characterization-and-model-identification-of-the-nonlinear-compressible-material-behavior-of-lung-parenchyma
#15
Anna M Birzle, Christian Martin, Lena Yoshihara, Stefan Uhlig, Wolfgang A Wall
The mechanical properties of lung parenchyma are essential both in lung function and biology; consequently, experimental methods are developed to describe the mechanical behavior of lung parenchyma. During breathing and mechanical ventilation, volume change is the physiologically dominating deformation mode of lung parenchyma; nevertheless, most studies examine lung tissue in mainly isochoric tension tests. In this paper, a novel experimental method for the quantification of the compressible material behavior at high volume changes of viable lung parenchyma is proposed...
August 5, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28822736/-rhinovirus-underestimated-pathogens-in-patients-during-the-neonatal-period
#16
S Zacharie, A Vabret, B Guillois, C Dupont, J Brouard
INTRODUCTION: In recent years, developments in virological tools have led to the easy detection of rhinoviruses and enteroviruses (E/RV). Their detection is very frequent in cases of airway involvement in children and their demonstrated causality. But the morbidity of E/RV in the neonatal period is unknown due to lack of epidemiological data. The objective of this study was to evaluate the incidence and clinical characteristics of these infections in hospitalized neonates. MATERIALS AND METHODS: We retrospectively analyzed the virology specimens of all neonates hospitalized at the Caen University Hospital between 2006 and 2011...
August 16, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28822689/cholesterol-lowering-gene-therapy-counteracts-the-development-of-non-ischemic-cardiomyopathy-in-mice
#17
Ilayaraja Muthuramu, Ruhul Amin, Andrey Postnov, Mudit Mishra, Joseph Pierre Aboumsallem, Tom Dresselaers, Uwe Himmelreich, Paul P Van Veldhoven, Olivier Gheysens, Frank Jacobs, Bart De Geest
A causal role of hypercholesterolemia in non-ischemic heart failure has never been demonstrated. Adeno-associated viral serotype 8 (AAV8)-low-density lipoprotein receptor (AAV8-LDLr) gene transfer was performed in LDLr-deficient mice without and with pressure overload induced by transverse aortic constriction (TAC). AAV8-LDLr gene therapy resulted in an 82.8% (p < 0.0001) reduction of plasma cholesterol compared with controls. Mortality rate was lower (p < 0.05) in AAV8-LDLr TAC mice compared with control TAC mice (hazard ratio for mortality 0...
August 1, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28822668/intrinsic-wave-propagation-of-myocardial-stretch-a-new-tool-to-evaluate-myocardial-stiffness-a-pilot-study-in-patients-with-aortic-stenosis-and-mitral-regurgitation
#18
Cristina Pislaru, Mahmoud M Alashry, Jeremy J Thaden, Patricia A Pellikka, Maurice Enriquez-Sarano, Sorin V Pislaru
BACKGROUND: Left ventricular (LV) filling following atrial contraction generates LV myocardial stretch that propagates from base to apex with a speed proportional to myocardial elasticity. The aim of this study was to test the hypothesis that intrinsic velocity propagation of myocardial stretch (iVP) would be altered in patients with valvular disease and chronic LV pressure overload or volume overload, which may adversely affect mechanical properties of the LV tissue. A second aim was to compare iVP with flow propagation velocity in the chamber...
August 16, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28822667/doppler-parameters-derived-from-transthoracic-echocardiography-accurately-detect-bioprosthetic-mitral-valve-dysfunction
#19
Ryan J Spencer, Ken G Gin, Michael Y C Tsang, Teresa S M Tsang, Parvathy Nair, Pui K Lee, John Jue
BACKGROUND: Detecting bioprosthetic mitral valve dysfunction on transthoracic echocardiography can be challenging because of acoustic shadowing of regurgitant jets and a wide normal range of transvalvular gradients. Several studies in mechanical mitral valves have demonstrated the utility of the transthoracically derived parameters E (peak early mitral inflow velocity), pressure half-time, and the ratio of mitral inflow velocity-time integral (VTIMV) to left ventricular outflow tract velocity-time integral (VTILVOT) in detecting significant prosthetic dysfunction...
August 16, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28822574/analysis-of-individual-and-total-microcystins-in-surface-water-by-on-line-preconcentration-and-desalting-coupled-to-liquid-chromatography-tandem-mass-spectrometry
#20
Gabriel Munoz, Sung Vo Duy, Audrey Roy-Lachapelle, Barry Husk, Sébastien Sauvé
A fast and high-throughput method is proposed for the determination of total microcystins (ΣMC) in environmental surface waters. After a 1-h Lemieux-von Rudloff oxidation step to yield the 2-methyl-3-methoxy-4-phenylbutyric acid (MMPB) moiety, samples were quenched, filtered, and directly analyzed. This was achieved via solid phase extraction (SPE) coupled on-line to ultra-high performance liquid chromatography electrospray ionization triple stage quadrupole mass spectrometry. The choice of on-line SPE settings was conducted using experimental designs...
August 5, 2017: Journal of Chromatography. A
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