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Rapid Response System

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https://www.readbyqxmd.com/read/29679824/extended-producer-responsibility-and-corporate-performance-effects-of-environmental-regulation-and-environmental-strategy
#1
Benhong Peng, Yu Tu, Ehsan Elahi, Guo Wei
While contemporary manufacturing technologies stimulate the industrial revolution and promote the rapidly changing global economy, it has caused enormous environmental negative externalities and managing the industrial waste remains a primary challenge, especially for fast developing countries such as China. Though existing studies explored the influence of Extended Producer Responsibility (EPR) legislations on environmental externalities, only fewer researches aimed at policy issues. Particularly, the relationship among environmental regulations, environmental strategies and corporate performance in the EPR system has not been deeply investigated...
April 18, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29679694/the-introduction-of-a-rapid-response-system-in-acute-hospitals-a-pragmatic-stepped-wedge-cluster-randomised-controlled-trial
#2
Filip Haegdorens, Peter Van Bogaert, Ella Roelant, Koen De Meester, Marie Misselyn, Kristien Wouters, Koenraad G Monsieurs
AIM: Deterioration of hospitalised patients is often missed, misinterpreted, and mismanaged. Rapid Response Systems (RRSs) have been proposed to solve this problem. This study aimed to investigate the effect of an RRS on the incidence of unexpected death, cardiac arrest with cardiopulmonary resuscitation (CPR), and unplanned intensive care unit (ICU) admission. METHODS: We conducted a stepped wedge cluster randomised controlled trial including 14 Belgian acute care hospitals with two medical and two surgical wards each...
April 18, 2018: Resuscitation
https://www.readbyqxmd.com/read/29679614/the-regulation-of-birdsong-by-testosterone-multiple-time-scales-and-multiple-sites-of-action
#3
REVIEW
Beau A Alward, Charlotte A Cornil, Jacques Balthazart, Gregory F Ball
Sex steroid hormones act during early development to shape the circuitry upon which these same hormones act in adulthood to control behavioral responses to various stimuli. The "organizational" vs. "activational" distinction was proposed to explain this temporal difference in hormone action. In both of these cases steroids were thought to act genomically over a time-scale of days to weeks. However, sex steroids can affect behavior over short (e.g., seconds or minutes) time-scales. Here, we discuss how testosterone controls birdsong via actions at different sites and over different time-scales, with an emphasis on this process in canaries (Serinus canaria)...
April 18, 2018: Hormones and Behavior
https://www.readbyqxmd.com/read/29678675/towards-tailored-management-of-malignant-brain-tumors-with-nanotheranostics
#4
REVIEW
Juan Aparicio-Blanco, Ana-Isabel Torres-Suárez
Malignant brain tumors still represent an unmet medical need given their rapid progression and often fatal outcome within months of diagnosis. Given their extremely heterogeneous nature, the assumption that a single therapy could be beneficial for all patients is no longer plausible. Hence, early feedback on drug accumulation at the tumor site and on tumor response to treatment would help tailor therapies to each patient's individual needs for personalized medicine. In this context, at the intersection between imaging and therapy, theranostic nanomedicine is a promising new technique for individualized management of malignant brain tumors...
April 17, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29678561/distribution-of-take-home-opioid-antagonist-kits-during-a-synthetic-opioid-epidemic-in-british-columbia-canada-a-modelling-study
#5
Michael A Irvine, Jane A Buxton, Michael Otterstatter, Robert Balshaw, Reka Gustafson, Mark Tyndall, Perry Kendall, Thomas Kerr, Mark Gilbert, Daniel Coombs
BACKGROUND: Illicit use of high-potency synthetic opioids has become a global issue over the past decade. This misuse is particularly pronounced in British Columbia, Canada, where a rapid increase in availability of fentanyl and other synthetic opioids in the local illicit drug supply during 2016 led to a substantial increase in overdoses and deaths. In response, distribution of take-home naloxone (THN) overdose prevention kits was scaled up (6·4-fold increase) throughout the province...
April 17, 2018: Lancet. Public Health
https://www.readbyqxmd.com/read/29678490/in-situ-observation-of-single-cell-response-to-acoustic-droplet-vaporization-membrane-deformation-permeabilization-and-blebbing
#6
Dui Qin, Lei Zhang, Nan Chang, Pengying Ni, Yujin Zong, Ayache Bouakaz, Mingxi Wan, Yi Feng
In this study, the bioeffects of acoustic droplet vaporization (ADV) on adjacent cells were investigated by evaluating the real-time cell response at the single-cell level in situ, using a combined ultrasound-exposure and optical imaging system. Two imaging modalities, high-speed and fluorescence imaging, were used to observe ADV bubble dynamics and to evaluate the impact on cell membrane permeabilization (i.e., sonoporation) using propidium iodide (PI) uptake as an indicator. The results indicated that ADV mainly led to irreversible rather than reversible sonoporation...
February 6, 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29677667/co-evolutionary-dynamics-of-the-human-environment-system-in-the-heihe-river-basin-in-the-past-2000years
#7
Zhixiang Lu, Yongping Wei, Qi Feng, Jiali Xie, Honglang Xiao, Guodong Cheng
There is limited quantitative understanding of interactions between human and environmental systems over the millennial scale. We aim to reveal the co-evolutionary dynamics of the human-environment system in a river basin by simulating the water use and net primary production (NPP) allocation for human and environmental systems over the last 2000years in Heihe River basin (HRB) in northwest China. We partition the catchment total evapotranspiration (ET) into ET for human and environmental systems with a social-hydrological framework and estimate the NPP for human and environmental systems using the Box-Lieth model, then classify the co-evolutionary processes of the human-environment system into distinct phases using the rate of changes of NPP over time, and discover the trade-offs or synergies relationships between them based on the elasticity of change of the NPP for humans to the change of NPP for environment...
April 17, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29677448/self-assembled-ph-responsive-polymeric-micelles-for-highly-efficient-non-cytotoxic-delivery-of-doxorubicin-chemotherapy-to-inhibit-macrophage-activation-in-vitro-investigation
#8
Zhi-Sheng Liao, Shan-You Huang, Jyun-Jie Huang, Jem-Kun Chen, Ai-Wei Lee, Juin-Yih Lai, Duu-Jong Lee, Chih-Chia Cheng
Self-assembled pH-responsive polymeric micelles, a combination of hydrophilic poly(ethylene glycol) segments and hydrogen bonding interactions within a biocompatible polyurethane substrate, can spontaneously self-assemble into highly controlled, nanosized micelles in aqueous solution. These newly-developed micelles exhibit excellent pH-responsive behavior and biocompatibility, highly controlled drug (doxorubicin; DOX) release behavior and high drug encapsulation stability in different aqueous environments, making the micelles highly attractive potential candidates for safer, more effective drug delivery in applications such as cancer chemotherapy...
April 20, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29677213/ifn-%C3%AE-and-micrornas-are-important-modulators-of-the-pulmonary-innate-immune-response-against-influenza-a-h1n2-infection-in-pigs
#9
Louise Brogaard, Lars E Larsen, Peter M H Heegaard, Christian Anthon, Jan Gorodkin, Ralf Dürrwald, Kerstin Skovgaard
The innate immune system is paramount in the response to and clearance of influenza A virus (IAV) infection in non-immune individuals. Known factors include type I and III interferons and antiviral pathogen recognition receptors, and the cascades of antiviral and pro- and anti-inflammatory gene expression they induce. MicroRNAs (miRNAs) are increasingly recognized to participate in post-transcriptional modulation of these responses, but the temporal dynamics of how these players of the antiviral innate immune response collaborate to combat infection remain poorly characterized...
2018: PloS One
https://www.readbyqxmd.com/read/29676473/horn-growth-variation-and-hunting-selection-of-the-alpine-ibex
#10
Ulf Büntgen, Juan D Galván, Atle Mysterud, Paul J Krusic, Lisa Hülsmann, Hannes Jenny, Josef Senn, Kurt Bollmann
1.Selective hunting can affect demographic characteristics and phenotypic traits of the targeted species. Hunting systems often involve harvesting quotas based on sex, age and/or size categories to avoid selective pressure. However, it is difficult to assess if such regulations deter hunters from targeting larger 'trophy' animals with longer horns that may have evolutionary consequences. 2.Here, we compile 44'088 annually resolved and absolutely dated measurements of Alpine ibex (Capra ibex) horn growth increments from 8'355 males, harvested between 1978 and 2013, in the eastern Swiss Canton of Grisons...
April 20, 2018: Journal of Animal Ecology
https://www.readbyqxmd.com/read/29675459/bioengineered-systems-and-designer-matrices-that-recapitulate-the-intestinal-stem-cell-niche
#11
REVIEW
Yuli Wang, Raehyun Kim, Samuel S Hinman, Bailey Zwarycz, Scott T Magness, Nancy L Allbritton
The relationship between intestinal stem cells (ISCs) and the surrounding niche environment is complex and dynamic. Key factors localized at the base of the crypt are necessary to promote ISC self-renewal and proliferation, to ultimately provide a constant stream of differentiated cells to maintain the epithelial barrier. These factors diminish as epithelial cells divide, migrate away from the crypt base, differentiate into the postmitotic lineages, and end their life span in approximately 7 days when they are sloughed into the intestinal lumen...
March 2018: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29674022/an-automated-salting-out-assisted-liquid-liquid-microextraction-approach-using-1-octylamine-on-line-separation-of-tetracycline-in-urine-samples-followed-by-hplc-uv-determination
#12
Ksenia Cherkashina, Christina Vakh, Sofya Lebedinets, Aleksei Pochivalov, Leonid Moskvin, Aleksey Lezov, Andrey Bulatov
An automated salting-out assisted liquid-liquid microextraction (SALLME) procedure based on a flow system was developed as new approach for pretreatment of complex sample matrix. In this procedure 1-octylamine was investigated as novel extractant for the SALLME. The procedure involved aspiration of the 1-octylamine and sample solution into a mixing chamber of a flow system followed by their air-bubble mixing resulting to isotropic solution formation. To provide phase separation a salting-out agent solution was added into the mixing chamber...
July 1, 2018: Talanta
https://www.readbyqxmd.com/read/29673910/-everyone-just-ate-good-food-good-food-in-islamabad-pakistan
#13
Saher Hasnain
In recent years, consumption of alternatively produced foods has increased in popularity in response to the deleterious effects of rapidly globalising and industrialised food systems. Concerns over food safety in relation to these changes may result from elevated levels of risk and changing perceptions associated with food production practices. This paper explores how the middle class residents of Islamabad, Pakistan, use the concept of 'good food' to reconnect themselves with nature, changing food systems, and traditional values...
April 16, 2018: Appetite
https://www.readbyqxmd.com/read/29673645/intranasal-delivery-of-adjuvant-free-peptide-nanofibers-elicits-resident-cd8-t-cell-responses
#14
Youhui Si, Yi Wen, Sean H Kelly, Anita S Chong, Joel H Collier
Influenza vaccines that can be administered intranasally or by other needle-free delivery routes have potential advantages over injected formulations in terms of patient compliance, cost, and ease of global distribution. Supramolecular peptide nanofibers have been investigated previously as platforms for vaccines and immunotherapies and have been shown to raise immune responses in the absence of exogenous adjuvants and without measurable inflammation. However, at present it has not been tested whether the immunogenicity of these materials extends to the intranasal route...
April 16, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29671817/assessment-of-regional-ecosystem-health-a-case-study-of-the-golden-triangle-of-southern-fujian-province-china
#15
Ziyan Wang, Lina Tang, Quanyi Qiu, Huaxiang Chen, Tong Wu, Guofan Shao
Intensifying urbanization and rapid population growth in Fujian Province, China, has caused pollution of air and water resources; this has adversely impacted ecosystems and human health. China has recently begun pursuing a massive infrastructure and economic development strategy called the Belt and Road Initiative, which could potentially cause further environmental damage. Evaluations of ecosystem health are therefore a first step towards identifying the potential impacts from the development and planning sustainable development strategies in the Golden Triangle of Southern Fujian...
April 19, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29670282/global-warming-transforms-coral-reef-assemblages
#16
Terry P Hughes, James T Kerry, Andrew H Baird, Sean R Connolly, Andreas Dietzel, C Mark Eakin, Scott F Heron, Andrew S Hoey, Mia O Hoogenboom, Gang Liu, Michael J McWilliam, Rachel J Pears, Morgan S Pratchett, William J Skirving, Jessica S Stella, Gergely Torda
Global warming is rapidly emerging as a universal threat to ecological integrity and function, highlighting the urgent need for a better understanding of the impact of heat exposure on the resilience of ecosystems and the people who depend on them 1 . Here we show that in the aftermath of the record-breaking marine heatwave on the Great Barrier Reef in 2016 2 , corals began to die immediately on reefs where the accumulated heat exposure exceeded a critical threshold of degree heating weeks, which was 3-4 °C-weeks...
April 18, 2018: Nature
https://www.readbyqxmd.com/read/29670218/the-impact-of-genome-variation-and-diet-on-the-metabolic-phenotype-and-microbiome-composition-of-drosophila-melanogaster
#17
Lisa Jehrke, Fiona A Stewart, Andrea Droste, Mathias Beller
The metabolic phenotype of an organism depends on a complex regulatory network, which integrates the plethora of intrinsic and external information and prioritizes the flow of nutrients accordingly. Given the rise of metabolic disorders including obesity, a detailed understanding of this regulatory network is in urgent need. Yet, our level of understanding is far from completeness and complicated by the discovery of additional layers in metabolic regulation, such as the impact of the microbial community present in the gut on the hosts' energy storage levels...
April 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29669782/the-respiratory-environment-diverts-the-development-of-antiviral-memory-cd8-t-cells
#18
Hillary L Shane, Katie L Reagin, Kimberly D Klonowski
Our understanding of memory CD8+ T cells has been largely derived from acute, systemic infection models. However, memory CD8+ T cells generated from mucosal infection exhibit unique properties and, following respiratory infection, are not maintained in the lung long term. To better understand how infection route modifies memory differentiation, we compared murine CD8+ T cell responses to a vesicular stomatitis virus (VSV) challenge generated intranasally (i.n.) or i.v. The i.n. infection resulted in greater peak expansion of VSV-specific CD8+ T cells...
April 18, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29666944/macrophages-play-an-essential-role-in-trauma-induced-sterile-inflammation-and-tissue-repair
#19
REVIEW
Moritz Peiseler, Paul Kubes
Severe trauma is accompanied by a profound activation of the immune system. Patients with polytrauma develop systemic inflammatory response syndrome (SIRS) and often sepsis, which contributes substantially to high mortality of this condition. On a cellular level, necrosis and loss of plasma membrane integrity lead to the release of endogenous "damage-associated molecular patterns" (DAMPs) as danger signals, which in turn activate innate immune cells. Inflammation that occurs in the absence of invading pathogens has been termed sterile inflammation and trauma with tissue damage represents an acute form of sterile inflammation...
April 17, 2018: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/29666198/nest-predation-risk-modifies-nestlings-immune-function-depending-on-the-level-of-threat
#20
G Roncalli, E Colombo, M Soler, B I Tieleman, M A Versteegh, F Ruiz-Raya, M Gómez Samblas, J D Ibáñez-Álamo
Predation risk is thought to modify prey's physiology mainly through the stress response. However, little is known about its potential effects on the immunity of animals, particularly in young individuals, despite the importance to overcome wounding and pathogen aggression following a predator attack. We investigated the effect of four progressive levels of nest predation risk on several components of the immune system in common blackbird ( Turdus merula ) nestlings by presenting them with four different calls during 1h: non-predator calls, predator calls, parental alarm calls and conspecific distress calls to induce a null, moderate, high and extreme level of risk, respectively...
April 17, 2018: Journal of Experimental Biology
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