Song-Song Xu, Nan Wang, Lei Huang, Xiu-Ling Zhang, Shu-Tang Feng, Sha-Sha Liu, Yue Wang, Zhi-Guo Liu, Bing-Yuan Wang, Tian-Wen Wu, Yu-Lian Mu, Shao-Hua Hou, Kui Li
Several studies have suggested a role for gut mucosa-associated microbiota in the development of obesity, but the mechanisms involved are poorly defined. Here, the impact of the gut mucosa-associated microbiota on obesity and related metabolic disorders was evaluated in a metabolic syndrome (MetS) porcine model. Body composition was determined among male Wuzhishan minipigs consuming a high-energy diet (HED) and compared to that of those consuming a normal diet (ND), and gut segments (duodenum, jejunum, ileum, cecum, colon, and rectum) were sampled for paired analysis of mucosa-associated microbiota and transcriptome signatures with 16S rRNA gene and RNA sequencing, respectively...
August 31, 2022: Microbiology Spectrum