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https://www.readbyqxmd.com/read/29679510/molecular-characteristics-of-multifocal-brain-histiocytic-sarcoma
#1
Florent Marguet, Nicolas Piton, Homa Adle-Biassette, Florence Renaud, Elodie Bohers, Thomas Boyer, Aline Zarea, Stéphane Derrey, Jean Christophe Sabourin, Annie Laquerrière
Histiocytic sarcoma (HS) is a very uncommon malignant proliferation accounting for less than 1% of all neoplasms of hematopoietic and lymphoid tissues. According to the 2008 WHO classification of haematological and lymphoid tumours, diagnosis of HS requires histological and immunohistochemical evidence of histiocytic differentiation [1]. The 2016 Central nervous system (CNS) WHO classification parallels the categories of the corresponding WHO classification of hematopoietic and lymphoid tissues. By definition, diagnosis of HS relies on the expression of at least two of the histiocytic markers, e...
April 21, 2018: Neuropathology and Applied Neurobiology
https://www.readbyqxmd.com/read/29673829/improving-the-rehabilitation-of-older-people-after-emergency-hospital-admission
#2
REVIEW
S McKelvie, A M Hall, H R Richmond, S Finnegan, D Lasserson
PURPOSE: Older adults are at risk of functional decline during emergency hospital admissions. This review aims to understand which exercise-based interventions are effective in improving function for older adults who experience unplanned admissions. METHODS: Database searches identified randomised control trials (RCTs) comparing exercise-based interventions with usual hospital care. The primary outcome was functional status measured by activities of daily living (ADL) scores...
May 2018: Maturitas
https://www.readbyqxmd.com/read/29673359/developing-a-risk-prediction-model-for-the-functional-outcome-after-hip-arthroscopy
#3
Patrick Stephan, Maarten A Röling, Nina M C Mathijssen, Gerjon Hannink, Rolf M Bloem
BACKGROUND: Hip arthroscopic treatment is not equally beneficial for every patient undergoing this procedure. Therefore, the purpose of this study was to develop a clinical prediction model for functional outcome after surgery based on preoperative factors. METHODS: Prospective data was collected on a cohort of 205 patients having undergone hip arthroscopy between 2011 and 2015. Demographic and clinical variables and patient reported outcome (PRO) scores were collected, and considered as potential predictors...
April 19, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29673165/a-novel-detection-model-and-its-optimal-features-to-classify-falls-from-low-and-high-acceleration-activities-of-daily-life-using-an-insole-sensor-system
#4
Benjamin Cates, Taeyong Sim, Hyun Mu Heo, Bori Kim, Hyunggun Kim, Joung Hwan Mun
In order to overcome the current limitations in current threshold-based and machine learning-based fall detectors, an insole system and novel fall classification model were created. Because high-acceleration activities have a high risk for falls, and because of the potential damage that is associated with falls during high-acceleration activities, four low-acceleration activities, four high-acceleration activities, and eight types of high-acceleration falls were performed by twenty young male subjects. Encompassing a total of 800 falls and 320 min of activities of daily life (ADLs), the created Support Vector Machine model’s Leave-One-Out cross-validation provides a fall detection sensitivity (0...
April 17, 2018: Sensors
https://www.readbyqxmd.com/read/29672647/mapping-the-knowledge-structure-of-frailty-in-journal-articles-by-text-network-analysis
#5
Youngji Kim, Soong-Nang Jang
BACKGROUNDS: This study was to understand the trends of frailty research and networking features of keywords from the academic articles focusing on frailty in the last four decades. METHOD: Keywords were extracted from articles (n = 6,424) retrieved from Web of Science, from 1981 to April 2016, using Bibexcel, and a social network analysis was conducted using Net Miner. RESULTS: The core-keywords of research on frailty are constantly changing over the last 40 years...
2018: PloS One
https://www.readbyqxmd.com/read/29672507/unconventional-function-of-an-achaete-scute-homolog-as-a-terminal-selector-of-nociceptive-neuron-identity
#6
Neda Masoudi, Saeed Tavazoie, Lori Glenwinkel, Leesun Ryu, Kyuhyung Kim, Oliver Hobert
Proneural genes are among the most early-acting genes in nervous system development, instructing blast cells to commit to a neuronal fate. Drosophila Atonal and Achaete-Scute complex (AS-C) genes, as well as their vertebrate orthologs, are basic helix-loop-helix (bHLH) transcription factors with such proneural activity. We show here that a C. elegans AS-C homolog, hlh-4, functions in a fundamentally different manner. In the embryonic, larval, and adult nervous systems, hlh-4 is expressed exclusively in a single nociceptive neuron class, ADL, and its expression in ADL is maintained via transcriptional autoregulation throughout the life of the animal...
April 2018: PLoS Biology
https://www.readbyqxmd.com/read/29672358/replacement-of-the-6-min-walk-test-with-glittre-adl-test-and-scores-from-the-pfsdq-m-and-hap-questionnaires-in-the-bode-index
#7
Fabiana B R Moreira, Marcelo B de Fuccio, Giane Amorim Ribeiro-Samora, Marcelo Velloso
PURPOSE: Chronic obstructive pulmonary disease reduces functional capacity, which is strongly correlated with the morbidity and mortality of patients. The BODE index considers the multifactorial nature of the disease, including the functional capacity measured by the 6-min walk test (6MWT), and this index predicts the mortality in patients with chronic obstructive pulmonary disease. Our aim was to assess whether association exists between the original BODE index and the modified BODE index by replacing the 6MWT with the scores from the Pulmonary Functional Status and Dyspnea Questionnaire-Modified version (PFSDQ-M), Human Activity Profile (HAP) questionnaire, and the results of the Glittre ADL Test (TGlittre)...
April 18, 2018: Journal of Cardiopulmonary Rehabilitation and Prevention
https://www.readbyqxmd.com/read/29672352/association-of-activities-of-daily-living-with-the-load-during-step-ascent-motion-in-nursing-home-residing-elderly-individuals
#8
Mitsuhiro Masaki, Tome Ikezoe, Midori Kamiya, Kojiro Araki, Ryo Isono, Takehiro Kato, Ken Kusano, Masayo Tanaka, Syunsuke Sato, Tetsuya Hirono, Kiyoshi Kita, Tadao Tsuboyama, Noriaki Ichihashi
OBJECTIVE: This study aimed to examine the association of independence in ADL with the loads during step ascent motion and other motor functions in 32 nursing home-residing elderly individuals. DESIGN: Independence in ADL was assessed by using the functional independence measure (FIM). The loads at the upper (i.e., pulling up) and lower (i.e., pushing up) levels during step ascent task was measured on a step ascent platform. Hip extensor, knee extensor, plantar flexor muscle, and quadriceps setting strengths; lower extremity agility using the stepping test; and hip and knee joint pain severities were measured...
April 19, 2018: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/29669268/frailty-and-cognitive-status-evaluation-can-better-predict-mortality-in-older-adults
#9
Ivan Aprahamian, Claudia Kimie Suemoto, Márlon Juliano Romero Aliberti, Sileno de Queiroz Fortes Filho, Juliana de Araújo Melo, Sumika Mori Lin, Wilson Jacob Filho
OBJECTIVES: to evaluate the improvement in one-year mortality prediction after adding a 2-min cognitive screening to a simple 1-min frailty detection instrument. Secondary outcomes were new activities of daily living (ADL) disability and falls. DESIGN: Prospective cohort study. SETTING: A geriatric day-hospital for intermediate care. PARTICIPANTS: A total of 701 older adults with an acute or decompensated disease (79...
April 11, 2018: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/29667152/falls-in-mexican-older-adults-aged-60-years-and-older
#10
Luis M Valderrama-Hinds, Soham Al Snih, Nai-Wei Chen, Martin A Rodriguez, Rebeca Wong
BACKGROUND: Falls are a major cause of disability, morbidity, institutionalization, and mortality in older adults. OBJECTIVES: The purpose of the study was to examine the risk factors for falls among Mexican older adults aged 60 years and older. METHODS: This study included 6247 participants and their spouse or partner aged 60 years and older from the Mexican Health and Aging Study, an ongoing longitudinal study (2001-2012) conducted in Mexico...
April 17, 2018: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29665103/health-and-care-related-risk-factors-for-suicide-among-nursing-home-residents-a-data-linkage-study
#11
Briony Murphy, Briohny Kennedy, Catherine Martin, Lyndal Bugeja, Melissa Willoughby, Joseph E Ibrahim
This study aimed to examine associations between health status and care needs of nursing home residents and risk of death from suicide compared to other causes through a retrospective data linkage cohort study examining nursing home resident deaths in Australia between 2000 and 2013. Data linkage was performed between aged care assessment tools-Resident Classification System and Aged Care Funding Instrument-and the National Coronial Information System. A competing risks survival analysis was performed to determine the association between care assessment variables (activities of daily living (ADL), behavior, and complex health care) and the risk of death from suicide and any other cause...
April 17, 2018: Suicide & Life-threatening Behavior
https://www.readbyqxmd.com/read/29663899/hiv-1-drug-resistance-profiles-for-the-hiv-protease-and-reverse-transcriptase-gene-in-patients-receiving-combination-therapy-in-tehran-iran
#12
Leila Sadeghi, Mahin Lolaie, Reza Adl Tabatabai, Saeed Bayanolhagh, Leila Taj, Niloofar Eghbal Ahmadi, Negin Abedinzadeh, Farzaneh Vakili, Ghazaleh Ahmadi, Minoo Mohraz
BACKGROUND: Determination of drug resistant mutations has a crucial role in the management of HIV-1 infected patients. OBJECTIVE: The aim of the current study was to evaluate drug resistance profile of RT and PR gene, and find the correlation between drug resistance mutation and ART regimen to intensify physicians ' options for the most effective therapy and help to establish health related policies at the national level in Iran. METHOD: HIV-1 RNA of 34 samples was extracted from plasma and RT Nested- PCR was performed and the final products were sequenced...
April 15, 2018: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/29663065/-individual-activation-of-dementia-sufferers-in-a-home-setting-a-randomized-controlled-study
#13
Renate Stemmer, Elmar Gräßel, Martin Schmid
BACKGROUND AND OBJECTIVES: The present project investigated the hypothesis that a multimodal individual activation of people with mild to moderate dementia in the home setting during a 6-month intervention period leads to improved everyday practice and cognitive abilities compared to the control group. MATERIAL AND METHODS: Intervention: a practical activation was performed by relatives 6 days per week. Cognitive stimulation took place once a week and was done by an external person...
April 16, 2018: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/29661205/comparison-between-minimally-invasive-spine-stabilization-with-and-without-posterior-decompression-for-the-management-of-spinal-metastases-a-retrospective-cohort-study
#14
Hiroshi Uei, Yasuaki Tokuhashi, Masafumi Maseda, Masahiro Nakahashi, Hirokatsu Sawada, Enshi Nakayama, Hirotoki Soma
BACKGROUND: Posterior decompression and stabilization plays significant roles in palliative surgery for metastatic spinal tumor. However, the indication for addition of posterior decompression have not been examined. The purpose of this study was to investigate a retrospective cohort of outcomes of metastatic spinal tumor treated with minimally invasive spine stabilization (MISt) with or without posterior decompression. METHODS: The subjects were 40 patients who underwent MISt using percutaneous pedicle screws for metastatic spinal tumor, including 20 patients treated with stabilization alone (group A) and 20 patients with added posterior decompression (group B)...
April 16, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29659593/the-complexity-of-patients-hospitalized-in-internal-medicine-wards-evaluated-by-fadoi-complimed-score-s-a-hypothetical-approach
#15
Erminio Bonizzoni, Gualberto Gussoni, Giancarlo Agnelli, Raffaele Antonelli Incalzi, Moira Bonfanti, Franco Mastroianni, Marco Candela, Carlotta Franchi, Stefania Frasson, Antonio Greco, Micaela La Regina, Roberta Re, Giorgio Vescovo, Mauro Campanini
OBJECTIVES: The aim of this study is to develop a new predictive model to measure complexity of patients in medical wards. SETTING: 29 Internal Medicine departments in Italy. MATERIALS AND METHODS: The study cohort was made of 541 consecutive patients hospitalized for any cause, aged more than 40 years and with at least two chronic diseases. First, we applied a hierarchical cluster analysis and the principal component analysis (PCA) to a panel of questionnaires [comorbidity (Charlson, CIRS), clinical stability (MEWS), social frailty (Flugelman), cognitive dysfunction (SPSMQ), depression (5-item GDS), functional dependence (ADL, IADL, Barthel), risk of sore threats (Exton-Smith scale), nutrition (MNA), pain (NRPS), adherence to therapy (Morisky scale)], in order to select domains informative for the definition of complexity...
2018: PloS One
https://www.readbyqxmd.com/read/29658799/the-validity-and-reliability-of-the-adl-glittre-test-for-children
#16
Renata Martins, Maíra S de Assumpção, Tatiana G Bobbio, Anamaria F Mayer, Camila Schivinski
OBJECTIVE: The ADL-Glittre was created to assess more comprehensively the essential activities of daily living in adults with chronic obstructive pulmonary disease. The aim of this study was to validate the ADL-Glittre test adapted for children (TGlittre-P) and verify its reliability. METHODS: This is a cross-sectional study with 87 healthy children aged 6 to 14 years (mean 10.36 ± 2.32 years). Biometric and spirometry data were collected from all participants...
April 16, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29658441/efficacy-of-transcranial-direct-current-stimulation-combined-with-cognitive-training-in-the-treatment-of-apathy-in-patients-with-alzheimer-s-disease-study-protocol-for-a-randomized-trial
#17
Jean-Paul Nguyen, Claire Boutoleau-Bretonniere, Jean-Pascal Lefaucheur, Alcira Suarez, Helene Gaillard, Guillaume Chapelet, Sebastien Abad, Aurelien Van Langhenhove, Julian Nizard, Laure de Decker
BACKGROUND: Apathy, commonly defined as loss of motivation, is a symptom frequently encountered in Alzheimer's disease (AD). The treatment of apathy remains challenging in the absence of any truly effective medications. Transcranial magnetic stimulation (rTMS) or transcranial direct current stimulation (tDCS) can improve cognitive disorders, but do not appear to improve apathy. Isolated cognitive training also appears to have no effect on apathy. We propose to test the efficacy of a new procedure for the treatment of apathy in AD patients consisting of a combination of tDCS and cognitive training, based on the latest guidelines for the design of therapeutic trials in this field...
April 16, 2018: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/29657870/is-the-serum-oxytocin-level-altered-by-treatment-in-rheumatoid-arthritis-patients-complicated-with-depression
#18
Yusuke Miwa, Hidekazu Furuya, Ryo Yanai, Tsuyoshi Kasama, Kenji Sanada
Objective: The objective of this study was to investigate the factors associated with depression, including serum oxytocin (OXT) levels, disease activity, activities of daily living (ADL), and quality of life (QOL), and their effects on rheumatoid arthritis (RA). Methods: This study included 42 RA patients who received treatment with a biological agent. We measured the following variables before and after 6 months of treatment: baseline characteristics, including age, sex, disease duration, smoking, and body mass index (BMI); prednisolone and methotrexate dose; serum level of matrix metalloproteinase-3 (MMP-3); erythrocyte sedimentation rate (ESR); and C-reactive protein (CRP) level...
March 2018: European Journal of Rheumatology
https://www.readbyqxmd.com/read/29655586/non-motor-outcomes-of-subthalamic-stimulation-in-parkinson-s-disease-depend-on-location-of-active-contacts
#19
Haidar Salimi Dafsari, Jan Niklas Petry-Schmelzer, K Ray-Chaudhuri, Keyoumars Ashkan, Luca Weis, Till A Dembek, Michael Samuel, Alexandra Rizos, Monty Silverdale, Michael T Barbe, Gereon R Fink, Julian Evans, Pablo Martinez-Martin, Angelo Antonini, Veerle Visser-Vandewalle, Lars Timmermann
BACKGROUND: Subthalamic nucleus (STN) deep brain stimulation (DBS) improves quality of life (QoL), motor, and non-motor symptoms (NMS) in Parkinson's disease (PD). Few studies have investigated the influence of the location of neurostimulation on NMS. OBJECTIVE: To investigate the impact of active contact location on NMS in STN-DBS in PD. METHODS: In this prospective, open-label, multicenter study including 50 PD patients undergoing bilateral STN-DBS, we collected NMSScale (NMSS), NMSQuestionnaire (NMSQ), Hospital Anxiety and Depression Scale (anxiety/depression, HADS-A/-D), PDQuestionnaire-8 (PDQ-8), Scales for Outcomes in PD-motor examination, motor complications, activities of daily living (ADL), and levodopa equivalent daily dose (LEDD) preoperatively and at 6 months follow-up...
March 16, 2018: Brain Stimulation
https://www.readbyqxmd.com/read/29655425/estimating-the-number-of-components-and-detecting-outliers-using-angle-distribution-of-loading-subspaces-adls-in-pca-analysis
#20
Y J Liu, T Tran, G Postma, L M C Buydens, J Jansen
Principal Component Analysis (PCA) is widely used in analytical chemistry, to reduce the dimensionality of a multivariate data set in a few Principal Components (PCs) that summarize the predominant patterns in the data. An accurate estimate of the number of PCs is indispensable to provide meaningful interpretations and extract useful information. We show how existing estimates for the number of PCs may fall short for datasets with considerable coherence, noise or outlier presence. We present here how Angle Distribution of the Loading Subspaces (ADLS) can be used to estimate the number of PCs based on the variability of loading subspace across bootstrap resamples...
August 22, 2018: Analytica Chimica Acta
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