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https://www.readbyqxmd.com/read/29215502/functional-limitations-due-to-stiffness-after-long-level-spinal-instrumented-fusion-surgery-to-correct-lumbar-degenerative-flat-back
#1
Jeong-Hoon Choi, Jee-Soo Jang, Kyong-Suk Yoo, Jong-Mog Shin, Il-Tae Jang Md
STUDY DESIGN: A retrospective analysis of functional limitations due to stiffness after long level spinal instrumented fusion surgery to correct lumbar degenerative flat back was performed OBJECTIVE.: To analysis the functional limitations in patients treated surgically for ALDFB with long level instrumented fusion to the sacrum or pelvis. SUMMARY OF BACKGROUND DATA: Long level instrumented fusion for adult lumbar degenerative flat back (ALDFB) decreases back pain and spinal deformity...
December 5, 2017: Spine
https://www.readbyqxmd.com/read/29214518/outcome-of-older-persons-admitted-to-intensive-care-unit-mortality-prognosis-factors-dependency-scores-and-ability-trajectory-within-1%C3%A2-year-a-prospective-cohort-study
#2
Claude Level, Eric Tellier, Patrick Dezou, Karim Chaoui, Aissa Kherchache, Philippe Sejourné, Anne Marie Rullion-Pac Soo
BACKGROUND: The outcome and functional trajectory of older persons admitted to intensive care (ICU) unit remain a true question for critical care physicians and geriatricians, due to the heterogeneity of geriatric population, heterogeneity of practices and absence of guidelines. AIM: To describe the 1-year outcome, prognosis factors and functional trajectory for older people admitted to ICU. METHODS: In a prospective 1-year cohort study, all patients aged 75 years and over admitted to our ICU were included according to a global comprehensive geriatric assessment...
December 6, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29214290/association-of-immunotherapy-with-overall-survival-in-elderly-patients-with-melanoma
#3
Marie Perier-Muzet, Elodie Gatt, Julien Péron, Claire Falandry, Mona Amini-Adlé, Luc Thomas, Stephane Dalle, Amelie Boespflug
Importance: Melanoma treatment has been revolutionized with the development of immune-based therapies that offer durable clinical responses in a subset of patients. Clinical outcomes after treatment by immunotherapy can be influenced by the host's immune system. The immune system is modified with age by age-related immune dysfunction. Objective: To evaluate if age influences clinical outcome and immune adverse events in patients treated by immunotherapy for metastatic melanoma...
December 6, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/29213491/prevalence-of-functional-cognitive-impairment-and-associated-factors-in-brazilian-community-dwelling-older-adults
#4
Andréa Silva Gondim, João Macedo Coelho Filho, Alexandre de Andrade Cavalcanti, Jarbas de Sá Roriz Filho, Charlys Barbosa Nogueira, Arnaldo Aires Peixoto Junior, José Wellington de Oliveira Lima
The identification of the prevalence of cognitive impairment and associated factors among older adults is important in countries facing rapid demographic transition, given the significant implications for public policy and health planning. Objective: To determine the prevalence of functional cognitive impairment (FCI) and associated factors in Brazilian community-dwelling older adults. Methods: A cross-sectional study involving 461 elderly subjects residing in Fortaleza city, Ceará was conducted...
January 2017: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29211233/elderly-caregivers-living-in-urban-rural-and-high-social-vulnerability-contexts
#5
Sofia Cristina Iost Pavarini, Anita Liberalesso Neri, Allan Gustavo Brígola, Ana Carolina Ottaviani, Érica Nestor Souza, Estefani Serafim Rossetti, Mariélli Terassi, Nathalia Alves de Oliveira, Bruna Moretti Luchesi
OBJECTIVE Comparing the differences in the sociodemographic, care and health profiles of elderly caregivers of the elderly living in urban, rural, and high social vulnerability contexts. METHOD A cross-sectional study developed with elderly caregivers enrolled in the Family Health Units of a municipality in the interior of São Paulo. Household interviews and evaluations were conducted on: Activities of Daily Living (ADL), self-reported pain, frailty, cognition, life satisfaction, family functionality, burden, stress and hope...
2017: Revista da Escola de Enfermagem da U S P
https://www.readbyqxmd.com/read/29208730/rituximab-for-corticosteroid-resistant-relapsing-igg4-related-intracranial-pachymeningitis-report-of-two-cases
#6
Arthur Mageau, Natalia Shor, Matthieu Fisselier, Jennifer Aboab, Augustin Lecler, Celeste Rebours, Homa Adle-Biassette, Olivier Gout, Romain Deschamps
IgG4-related disease is now recognised as an important cause of intracranial and spinal hypertrophic pachymeningitis. Treatment with corticosteroids generally leads to significant clinical improvement. We present two cases of IgG4 pachymeningitis unresponsive to corticosteroids who improved with rituximab.
December 5, 2017: Practical Neurology
https://www.readbyqxmd.com/read/29204976/three-year-functional-trajectories-among-old-age-survivors-and-decedents-dying-eliminates-a-racial-disparity
#7
June R Lunney, Steven M Albert, Robert Boudreau, Diane Ives, Suzanne Satterfield, Anne B Newman, Tamara Harris
BACKGROUND: Long-term trajectories of disability comparing decedents and survivors and differences by race have not been assessed. OBJECTIVE: To examine self-reported difficulty in walking a quarter mile and the need for assistance with activities of daily living (ADL) beginning 3 years before death among decedents and age- and gender-matched survivors. DESIGN: A case-control sample drawn from the Health, Aging and Body Composition Study (Health ABC)...
December 4, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29204426/burden-among-family-caregivers-of-dementia-in-the-oldest-old-an-exploratory-study
#8
Khin Khin Win, Mei Sian Chong, Noorhazlina Ali, Mark Chan, Wee Shiong Lim
Background: With >85 years, the fastest growing age segment in developed countries, dementia in the oldest-old is projected to increase exponentially. Being older, caregivers of dementia in oldest-old (CDOO) may experience unique challenges compared with younger-age groups. Thus, we aim to explore demographic characteristics and burden pattern among CDOO. Methods: We studied 458 family caregiver-patient dyads attending an outpatient memory clinic. We classified patients into three age-groups: <75, 75-84, and ≥85 years...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/29202548/comparing-the-levels-of-acute-phase-reactants-between-smoker-and-nonsmoker-diabetic-patients-more-predicted-risk-for-cardiovascular-diseases-in-smoker-compared-to-nonsmoker-diabetics
#9
Sepideh Rezaei-Adl, Arash Ghahroudi Tali, Hiva Saffar, Afsaneh Rajabiani, Alireza Abdollahi
 Due to a close link between cardiovascular disorders and increased acute phase responses, it is now proposed the relation of total sialic acid (TSA) and C Reactive Protein (CRP) as main components of acute phase proteins and cardiovascular risk profiles such as diabetes mellitus and smoking. We hypothesized that the elevation in the level of TSA along with other prototype acute phase reactants such as CRP is expected more in the coexistence of diabetes and smoking than in diabetes mellitus alone. Ninety diabetic patients were randomly selected and entered into this case-control study...
September 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/29201912/relationship-between-activities-of-daily-living-and-readmission-within-90-days-in-hospitalized-elderly-patients-with-heart-failure
#10
Masahiro Kitamura, Kazuhiro P Izawa, Hiroki Taniue, Yumi Mimura, Keita Imamura, Hitomi Nagashima, Peter H Brubaker
Aims: To examine the relationship between activities of daily living (ADL) and readmission within 90 days and assess the cutoff value of ADL to predict readmission in hospitalized elderly patients with heart failure (HF). Methods: This cohort study comprised 589 consecutive patients with HF aged ≥65 years, who underwent cardiac rehabilitation from May 2012 to May 2016 and were discharged home. We investigated patients' characteristics, basic attributes, and ADL (motor and cognitive Functional Independence Measure [FIM])...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29198368/trunk-musculoskeletal-response-in-maximum-voluntary-exertions-a-combined-measurement-modeling-investigation
#11
F Ghezelbash, Z El Ouaaid, A Shirazi-Adl, A Plamondon, N Arjmand
Maximum voluntary exertion (MVE) tasks quantify trunk strength and maximal muscle electromyography (EMG) activities with both clinical and biomechanical implications. The aims here are to evaluate the performance of an existing trunk musculoskeletal model, estimate maximum muscle stresses and spinal forces, and explore likely differences between males and females in maximum voluntary exertions. We, therefore, measured trunk strength and EMG activities of 19 healthy right-handed subjects (9 females and 10 males) in flexion, extension, lateral and axial directions...
November 21, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29197516/protopanaxadiol-derivative-ddpu-improves-behavior-and-cognitive-deficit-in-ad-mice-involving-regulation-of-both-er-stress-and-autophagy
#12
Xiaodan Guo, Jianlu Lv, Jian Lu, Lei Fan, Xi Huang, Lihong Hu, Jiaying Wang, Xu Shen
Alzheimer's disease (AD) is a progressively neurodegenerative disease with typical hallmarks of amyloid β (Aβ) plaque accumulation, neurofibrillary tangle (NFT) formation and neuronal death extension. Aggressive Aβ accumulation promotes senile plaque formation and perturbs endoplasmic reticulum (ER) function to trigger the unfolded protein response (UPR) leading to neuronal apoptosis. The stress-dependent activation of protein kinase RNA-like endoplasmic reticulum kinase (PERK) increases the phosphorylation of eukaryotic translation initiation factor-2α (eIF2α) to promote the preferential synthesis of β-site APP cleavage enzyme 1 (BACE1) and Aβ generation in turn...
November 29, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29194180/agitated-behavior-and-activities-of-daily-living-retraining-during-posttraumatic-amnesia
#13
Jessica Trevena-Peters, Jennie Ponsford, Adam McKay
BACKGROUND: Patients in posttraumatic amnesia (PTA) may receive limited rehabilitation due to the risk of overstimulation and agitation. This assumption has not been tested. OBJECTIVE: To examine the relationship between agitated behavior and participation in therapy for retraining of activities of daily living (ADL) while in PTA. SETTING: Inpatient rehabilitation center. PARTICIPANTS: A total of 104 participants with severe traumatic brain injury, admitted to rehabilitation, in PTA of more than 7 days...
November 29, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/29192535/prism-adaptation-in-rehabilitation-no-additional-effects-of-prism-adaptation-on-neglect-recovery-in-the-subacute-phase-poststroke-a-randomized-controlled-trial
#14
Antonia F Ten Brink, Johanna M A Visser-Meily, Martijn J Schut, Mirjam Kouwenhoven, Anja L H Eijsackers, Tanja C W Nijboer
BACKGROUND: Patients with neglect ignore or respond slower to contralesional stimuli. Neglect negatively influences independence in activities of daily living (ADL). Prism adaptation (PA) is one of the most frequently studied treatments, yet there is little evidence regarding positive effects on neglect behavior in ADL. OBJECTIVE: To assess whether PA in the subacute phase ameliorates neglect in situations of varying complexity. METHODS: A total of 70 neglect patients admitted for inpatient stroke rehabilitation received either PA or sham adaptation (SA) for 2 weeks, with full access to standard treatment...
November 1, 2017: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/29187897/glycan-and-peptide-ige-epitopes-of-the-tnf-alpha-blockers-infliximab-and-adalimumab-precision-diagnostics-by-cross-reactivity-immune-profiling-of-patient-sera
#15
Arne Homann, Niels Röckendorf, Arno Kromminga, Andreas Frey, Thomas A Platts-Mills, Uta Jappe
Biological drugs like therapeutic antibodies are widely used for the treatment of various diseases like inflammatory disorders and cancer. A drawback of these novel treatments is the substantial proportion of patients experiencing adverse reactions such as loss-of-drug effect or hypersensitivity reactions. These reactions are associated with pre-existing and/or developing anti-drug antibodies. Especially IgE development is a risk factor for life-threatening systemic anaphylaxis. METHODS: In order to characterize the individual drug-specific serum IgE, an IgE cross-reactivity immune profiling (ICRIP) assay was developed...
2017: Theranostics
https://www.readbyqxmd.com/read/29187327/endoscopic-retrograde-cholangiopancreatography-in-the-elderly-over-75-years-old-a-survey
#16
Coralie Labarias, Cédric Leguillou, Jean-François Bourgaux
Whilst endoscopic retrograde cholangiopancreatography (ERCP) is being practiced on increasingly older patients, its benefits have not been well studied. This study assessed the clinical benefit of ERCP for subjects aged 75 and over, including follow-up at 3 months of geriatric functional parameters and lifestyle. This is a prospective mono-centric, cohort study. All patients aged 75 and over receiving ERCP were enrolled and monitored for a period of 3 months. We recorded 53 inclusions between November 1st 2014 to 31 May 2015...
December 1, 2017: Gériatrie et Psychologie Neuropsychiatrie du Vieillissement
https://www.readbyqxmd.com/read/29187325/relevance-of-g8-scale-in-referring-elderly-patients-with-aortic-stenosis-requiring-a-tavi-for-a-geriatric-consultation
#17
Albane de Thézy, Aurélie Lafargue, Lydie d'Arailh, Marina Dijos, Lionel Leroux, Nathalie Salles, Muriel Rainfray
Aortic stenosis (AS) may soon become a significant public health issue. Referring elderly suffering from aortic stenosis for a transcatheter aortic valve implantation (TAVI) versus surgical valve replacement might be difficult and requires a multidisciplinary staff. G8 is a geriatric screening scale for frailty, validated in oncogeriatry. We study sensibility and specificity of G8 used by cardiologists in comparison to a comprehensive geriatric assessment (CGA) performed by geriatrician. Prospective study, from February to July 2015, in Bordeaux university Hospital, France...
December 1, 2017: Gériatrie et Psychologie Neuropsychiatrie du Vieillissement
https://www.readbyqxmd.com/read/29186746/-interdisciplinary-acute-medical-rehabilitation-after-sepsis-a-retrospective-analysis
#18
Max Emanuel Liebl, Nancy Elmer, Christine Schwedtke, Isabelle Schröder, Anett Reißhauer
Background Surviving sepsis may have consequences of high impact for the patients' further life regarding functioning in mobility and activities of daily living, among other fields. Patients consecutively have a great need of rehabilitation interventions beginning with early mobilization in the Intensive Care Unit ICU. Acute medical rehabilitation is a concept of early rehabilitation still in the acute care hospital, normally beginning after a direct transferal from the ICU. Its aim is to improve the patients' functioning in mobility and activities of daily living (ADL) to enable further post-acute rehabilitation interventions...
November 29, 2017: Die Rehabilitation
https://www.readbyqxmd.com/read/29183277/unfavorable-impact-of-cancer-cachexia-on-activity-of-daily-living-and-need-for-inpatient-care-in-elderly-patients-with-advanced-non-small-cell-lung-cancer-in-japan-a-prospective-longitudinal-observational-study
#19
Tateaki Naito, Taro Okayama, Takashi Aoyama, Takuya Ohashi, Yoshiyuki Masuda, Madoka Kimura, Hitomi Shiozaki, Haruyasu Murakami, Hirotsugu Kenmotsu, Tetsuhiko Taira, Akira Ono, Kazushige Wakuda, Hisao Imai, Takuya Oyakawa, Takeshi Ishii, Shota Omori, Kazuhisa Nakashima, Masahiro Endo, Katsuhiro Omae, Keita Mori, Nobuyuki Yamamoto, Akira Tanuma, Toshiaki Takahashi
BACKGROUND: Cancer cachexia in elderly patients may substantially impact physical function and medical dependency. The aim of this study was to estimate the impact of cachexia on activity of daily living (ADL), length of hospital stay, and inpatient medical costs among elderly patients with advanced non-small-cell lung cancer (NSCLC) receiving chemotherapy. METHODS: Thirty patients aged ≥70 years with advanced NSCLC (stage III-IV) scheduled to receive first-line chemotherapy were prospectively enrolled between January 2013 and November 2014...
November 28, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29183010/mild-to-moderate-chronic-kidney-disease-and-geriatric-outcomes-analysis-of-cross-sectional-data-from-the-berlin-aging-study-ii
#20
Maximilian König, Maik Gollasch, Dominik Spira, Nikolaus Buchmann, Werner Hopfenmüller, Elisabeth Steinhagen-Thiessen, Ilja Demuth
BACKGROUND: Mild-to-moderate chronic kidney disease (CKD G3a) is prevalent in older adults. Substantial evidence suggests that individuals with advanced CKD face a high risk for common geriatric conditions, like functional impairment and cognitive decline, whereas the relationships between mild-to-moderate CKD and functional impairment and cognitive decline, but also poor nutritional status and mood disorders, are still unclear. OBJECTIVE: The aim of this study was to explore associations between mild-to-moderate CKD and impairments in the core domains of geriatric assessment (GA) in a large cohort of community-dwelling older adults...
November 29, 2017: Gerontology
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