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Taylor J Brueseke, Maria de la Luz Nieto, Samantha Pulliam, Jennifer M Wu
OBJECTIVES: Anticholinergic medication use has been associated with cognitive impairment and other functional limitations, particularly in older patients. The anticholinergic risk score (ARS) can be used to measure a patient's cumulative exposure to medications with anticholinergic properties. Our primary objective was to evaluate the correlation between ARS and functional status, as measured by instrumental activities of daily living (IADL), in patients preparing to undergo urogynecologic surgery...
April 20, 2018: Female Pelvic Medicine & Reconstructive Surgery
Kyoungwon Seo, Ahreum Lee, Jieun Kim, Hokyoung Ryu, Hojin Choi
The inability to complete instrumental activities of daily living (IADL) is a precursor to various neuropsychological diseases. Questionnaire-based assessments of IADL are easy to use but prone to subjective bias. Here, we describe a novel virtual reality (VR) test to assess two complex IADL tasks: handling financial transactions and using public transportation. While a participant performs the tasks in a VR setting, a motion capture system traces the position and orientation of the dominant hand and head in a three-dimensional Cartesian coordinate system...
April 5, 2018: Journal of Visualized Experiments: JoVE
Marina Bruderer-Hofstetter, Anne-Kathrin Rausch-Osthoff, André Meichtry, Thomas Münzer, Karin Niedermann
Multicomponent interventions (MCT) combine physical exercises and cognitive training and seem to be most effective in improving cognition in elderly people. However, literature is inconclusive if MCTs are superior to active comparison interventions, if delivery modes matter, and if people can transfer achieved effects to instrumental activities of daily living (IADL). This network meta-analysis aimed to a) identify MCTs that were effective on physical capacity and/or cognitive function and able to transfer these effects into IADL in elderly people with normal cognition (NC) and mild cognitive impairment (MCI); b) provide a rating on the best interventions per outcome; c) evaluate MCTs' mode of delivery...
April 18, 2018: Ageing Research Reviews
Renate Stemmer, Elmar Gräßel, Martin Schmid
BACKGROUND AND OBJECTIVES: The present project investigated the hypothesis that a multimodal individual activation of people with mild to moderate dementia in the home setting during a 6-month intervention period leads to improved everyday practice and cognitive abilities compared to the control group. MATERIAL AND METHODS: Intervention: a practical activation was performed by relatives 6 days per week. Cognitive stimulation took place once a week and was done by an external person...
April 16, 2018: Zeitschrift Für Gerontologie und Geriatrie
Erminio Bonizzoni, Gualberto Gussoni, Giancarlo Agnelli, Raffaele Antonelli Incalzi, Moira Bonfanti, Franco Mastroianni, Marco Candela, Carlotta Franchi, Stefania Frasson, Antonio Greco, Micaela La Regina, Roberta Re, Giorgio Vescovo, Mauro Campanini
OBJECTIVES: The aim of this study is to develop a new predictive model to measure complexity of patients in medical wards. SETTING: 29 Internal Medicine departments in Italy. MATERIALS AND METHODS: The study cohort was made of 541 consecutive patients hospitalized for any cause, aged more than 40 years and with at least two chronic diseases. First, we applied a hierarchical cluster analysis and the principal component analysis (PCA) to a panel of questionnaires [comorbidity (Charlson, CIRS), clinical stability (MEWS), social frailty (Flugelman), cognitive dysfunction (SPSMQ), depression (5-item GDS), functional dependence (ADL, IADL, Barthel), risk of sore threats (Exton-Smith scale), nutrition (MNA), pain (NRPS), adherence to therapy (Morisky scale)], in order to select domains informative for the definition of complexity...
2018: PloS One
Jesus M Casida, Jean E Davis, Francis D Pagani, James E Aikens, Celeste Williams, James J Yang
The impact of sleep on LVAD patients' self-care behaviors is unknown. This study examined the patterns and changes of patients sleep quality (SQ), daytime sleepiness (DS), instrumental activities of daily living (IADL), and self-care capability (SCC) before and after LVAD. In addition, the relationships among these variables were explored. This observational study consisted of 38 subjects from two VAD Centers in Michigan. The subjects completed self-reported demographics and psychometrically sound SQ, DS, IADL, and SCC questionnaires before LVAD implant and at 1, 3, and 6 months after implant...
April 13, 2018: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
Gunay Ardali, Rebecca A States, Lori T Brody, Ellen M Godwin
BACKGROUND AND PURPOSE: The ability to get down and up from the floor or to perform a floor transfer (FT) is a vital and useful skill for older adults at risk of falling. Little is known about the health-related factors that separate older adults who can perform FT independently from those who cannot. Therefore, the specific aims of this cross-sectional study are to (1) describe and compare health-related factors among older adults who were independent, assisted, or dependent in FT performance; and (2) establish the parallel reliability between self-reported and actual performance of FT...
April 6, 2018: Journal of Geriatric Physical Therapy
Heidi D Nelson, Lily Lui, Kris Ensrud, Stephen R Cummings, Jane A Cauley, Teresa A Hillier
Objective: The objective of this study is to determine whether the health effects of smoking and moderate alcohol use persist with aging. Method: Smoking status, alcohol use, and measures of function and health were obtained from 9,704 women aged ≥65 years at baseline and over 10- and 20-year follow-up periods. Adjusted multiple linear and logistic regression and Cox proportional hazard models estimated associations. Results: Current versus never smokers had worse walking speed, self-reported health, difficulty with instrumental activities of daily living (IADLs), and depression at 10 years and higher death rates at 10 and 20 years...
January 2018: Gerontology & Geriatric Medicine
Manami Ejiri, Hisashi Kawai, Yoshinori Fujiwara, Kazushige Ihara, Hirohiko Hirano, Motonaga Kojima, Shuichi Obuchi
Objectives We aimed to investigate the predictors of social isolation among older people living in urban area.Methods A mail survey was sent out to 7,015 elderly subjects living in nine districts of Itabashi ward. At baseline (2012), 3,696 subjects and at follow-up (2014) 2,375 replied to the self-administered questionnaire. We defined social isolation as seeing friends or relatives less than two or three times a month. Gender, age, self-rated health, present illnesses, instrumental activities of daily living (IADL), frequency of going out, frequency of social participation, family structure, and perceived financial status were also investigated...
2018: [Nihon Kōshū Eisei Zasshi] Japanese Journal of Public Health
A M Wessels, S W Andersen, S A Dowsett, E R Siemers
The Integrated Alzheimer's Disease (AD) Rating Scale (iADRS) is a composite tool that combines scores from the AD Assessment Scale-Cognitive subscale (ADAS-Cog) and the AD Cooperative Study - instrumental Activities of Daily Living (ADCS-iADL). It demonstrates acceptable psychometric properties, and is effective in capturing both disease progression and separation of placebo and active drug effect. We assessed the performance of iADRS in the solanezumab EXPEDITION3 study, an 80-week, placebo-controlled study of individuals with mild AD dementia...
2018: Journal of Prevention of Alzheimer's Disease
Catherine Reed, Mark Belger, Grazia Dell'Agnello, Kristin Kahle-Wrobleski, Gopalan Sethuraman, Ann Hake, Joel Raskin, David Henley
BACKGROUND: Comparison of disease progression between placebo-group patients from randomised controlled trials (RCTs) and real-world patients can aid in assessing the generalisability of RCT outcomes. This analysis compared outcomes between community-dwelling patients with mild Alzheimer's disease (AD) dementia from two RCTs (pooled European (EU) data from EXPEDITION and EXPEDITION 2) and similar patients from the EU GERAS observational study. METHODS: Data from placebo-group patients with mild AD dementia from the RCTs (EU countries only) were compared with data from GERAS patients with mild AD dementia...
April 3, 2018: Alzheimer's Research & Therapy
Debbie Rand
BACKGROUND: Proprioception deficits are common post-stroke and predict poor functional outcome. It is unknown if the presence of proprioception deficits is negatively associated with the motor and functional ability of the affected upper extremity and daily living at the chronic stage post-stroke. AIMS: 1) To describe proprioception deficits of individuals with chronic stroke, 2) to correlate the severity of proprioception deficits with the motor and functional ability of the upper extremity, and 3) to compare independence in basic and instrumental activities in daily living (BADL, IADL), upper extremity motor and functional abilities between individuals with and without proprioception deficits...
2018: PloS One
Yosuke Osuka, Takao Suzuki, Miji Kim, Narumi Kojima, Ken Fujino, Yuko Yoshida, Hirohiko Hirano, Hunkyung Kim
Exercise can delay the decline of instrumental activities of daily living (IADL), although it remains unclear which specific exercise types are associated with such a delay. This 4-year prospective cohort study in Japan aimed to identify the longitudinal associations between exercise types and the onset of IADL decline in older women. Between 2008 and 2012, 1082 community-dwelling older women aged ≥75 years participated in this study. Participations in 16 exercise types based on a face-to-face interview at baseline were used as independent variables...
March 26, 2018: Preventive Medicine
Bum Jung Kim, Lin Liu, Christabel Cheung, Joonhee Ahn
The present study examined the effects of cognitive impairment and functional limitation on depressive symptoms among older Korean American immigrants. The sample was drawn from a cross-sectional survey of 210 older Korean immigrants (aged 65 years or older) in Los Angeles County. Based on robust hierarchical regression, the study found that cognitive ability and functional status were significant explanatory factors related to depressive symptoms among older Korean immigrants. In addition, the interaction of instrumental activities of daily living (IADL) and cognitive function (MMSE) had a significant effect on depressive symptoms...
2018: PloS One
L Liu, H Z Li, C Chen, C Liu, W X Cai
OBJECTIVES: To explore the application of activities of daily living (ADL) scale in mild psychiatric impairment assessment under the guideline of Classification of Human Body Disability Caused by Injury. METHODS: A total of 124 subjects with organic mental disorders and mild psychiatric impairments (levels 7 to 10), and 106 healthy controls were included in. All participants were assessed by the ADL scale, physical self-maintenance scale (PSMS) and instrumental activities of daily living (IADL) scale...
February 2018: Fa Yi Xue za Zhi
William E Mansbach, Melissa A Tanner, Francis Schindler
OBJECTIVES: The clinical assessment of older adults' judgment is important for mitigating safety risks that often precipitate loss of independence. Our national survey of geriatric healthcare providers (N = 496; M years of experience = 17.11 ± 10.60) indicated that formal judgment tests are underutilized in clinical practice. We developed the Verbal Test of Practical Judgment (VPJ) as a new test of judgment for older adults intended to identify difficulty performing instrumental activities of daily living (IADL)...
March 23, 2018: Aging & Mental Health
Shwu-Feng Tsay, Shih-Chung Chen, Shu-Jen Lu, Li-Ting Liu
Taiwan is projected to become an aged society in 2018. In addition to establishing a comprehensive, long-term care system that is able to deal with the expected impacts of population aging, it is imperative that the government focus on improving the prevention of aging-related conditions. This article introduces the innovative preventive care policy promoted by Taiwan's Ministry of Health and Welfare and its preliminary results. Furthermore, the foundational ideas behind this policy and how it is being executed are explained...
April 2018: Hu Li za Zhi the Journal of Nursing
Wiesje M van der Flier, Philip Scheltens
The Alzheimer center of the VU University Medical Center opened in 2000 and was initiated to combine both patient care and research. Together, to date, all patients forming the Amsterdam Dementia Cohort number almost 6,000 individuals. In this cohort profile, we provide an overview of the results produced based on the Amsterdam Dementia Cohort. We describe the main results over the years in each of these research lines: 1) early diagnosis, 2) heterogeneity, and 3) vascular factors. Among the most important research efforts that have also impacted patients' lives and/or the research field, we count the development of novel, easy to use diagnostic measures such as visual rating scales for MRI and the Amsterdam IADL Questionnaire, insight in different subgroups of AD, and findings on incidence and clinical sequelae of microbleeds...
2018: Journal of Alzheimer's Disease: JAD
Jessica Alber, Kelly McGarry, Richard B Noto, Peter J Snyder
Background: Recent genome-wide association screening (GWAS) studies have linked Alzheimer's disease (AD) neuropathology to gene networks that regulate immune function. Kan et al. recently reported that Arg1 (an anti-inflammatory gene that codes for arginase-1) is expressed in parts of the brain associated with amyloidosis prior to the onset of neuronal loss, suggesting that chronic brain arginine deprivation promotes AD-related neuropathology. They blocked arginine catabolism in their mouse AD model by administration of eflornithine (DFMO) to juvenile animals, effectively blocking the expression of AD-related amyloid pathology as the mice aged...
2018: Frontiers in Aging Neuroscience
Dorota Talarska, Sławomir Tobis, Marta Kotkowiak, Magdalena Strugała, Joanna Stanisławska, Katarzyna Wieczorowska-Tobis
BACKGROUND The ageing of population is the reason that there are various strategies developed to help seniors acquire greater independence and a better quality of life. The aim of this study was to explore the relationship between the elderly peope's need for assistance and assessed quality of life. MATERIAL AND METHODS The study included 100 participants who were members of a Seniors Club in Poznań, Poland. The cross-sectional study utilized the following instruments: Abbreviated Mental Test Score (AMTS), Instrumental Activities of Daily Living (IADL), EASY-Care Standard 2010 questionnaire, (WHO Quality of Life-BREF (WHOQOL-BREF) questionnaire...
March 19, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
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