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https://www.readbyqxmd.com/read/28443508/nutritional-deficiency-in-early-life-facilitates-aging-associated-cognitive-decline
#1
Yu Kang, Yun Zhang, Zijuan Feng, Mingjing Liu, Yanhua Li, Huan Yang, Dan Wang, Lingling Zheng, Dandan Lou, Liangping Cheng, Chunjiang Chen, Weitao Zhou, Yi Feng, Xiaoyong Li, Jianzhong Duan, Mengjiao Yu, Shou Yang, Yuhang Liu, Xin Wang, Bo Deng, Chenghui Liu, Xiuqing Yao, Chi Zhu, Chunrong Liang, Xiaolong Zeng, Sisi Ren, Qunying Li, Yin Zhong, Yong Zhang, Jun Kang, Yong Yan, Huaqing Meng, Zhaohui Zhong, Weihui Zhou, Yanjiang Wang, Tingyu Li, Weihong Song
BACKGROUND: Nutrition is important for the fetal developmental programming. Nutritional deficiency in early life could increase the susceptibility to many aging-related disorders including cognitive decline. OBJECTIVE: Our study aims to investigate the effect of early famine exposure on aging-associated cognitive function. METHODS: We recruited 6790 subjects born between 1956 to 1964 during which the Great Chinese Famine occurred (1959-1961)...
April 24, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28437525/visual-impairment-undercorrected-refractive-errors-and-activity-limitations-in-older-adults-findings-from-the-three-city-alienor-study
#2
Virginie Naël, Karine Pérès, Isabelle Carrière, Vincent Daien, Anne-Catherine Scherlen, Angelo Arleo, Jean-Francois Korobelnik, Cécile Delcourt, Catherine Helmer
Purpose: As vision is required in almost all activities of daily living, visual impairment (VI) may be one of the major treatable factors for preventing activity limitations. We aimed to evaluate the attributable risk of VI associated with activity limitations and the extent to which limitations are avoidable with optimal optical correction of undercorrected refractive errors. Methods: We analyzed 709 older adults from the Three-City-Alienor population-based study...
April 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28432547/health-related-quality-of-life-and-diabetes-self-care-activity-in-elderly-patients-with-diabetes-in-korea
#3
Hacksun Kim, Kisook Kim
A critical goal in the management of elderly patients with diabetes is to improve their health-related quality of life (HRQOL). This study aimed to identify the factors affecting HRQOL in elderly Korean patients with diabetes. Participants were 365 elderly patients with diabetes who were treated in a general hospital in Korea. The data were analysed using independent t-tests, Pearson correlations, and stepwise multiple regression. The mean total HRQOL score was 74.77, and HRQOL showed positive correlations with activities of daily living (ADL), instrumental activities of daily living (IADL), and the Summary of Diabetes Self-care Activities (SDSA)...
April 21, 2017: Journal of Community Health
https://www.readbyqxmd.com/read/28427049/predictive-validity-of-two-physical-frailty-phenotype-specifications-developed-for-investigation-of-frailty-pathways-in-older-people
#4
Yew Yoong Ding
BACKGROUND: For investigating the relationship of frailty with physical, psychological, and social conditions on pathways, the frailty definition should ideally exclude these conditions. Based on the frailty phenotype, 2 candidate physical frailty specifications or instruments with 3 indicators, namely slowness, weakness, and exhaustion, and 4 indicators with addition of weight loss were previously developed, and had their construct and concurrent validity demonstrated. OBJECTIVE: This study seeks to evaluate the predictive validity of 2 candidate physical frailty specifications with respect to death, functional impairment, and poor quality of life in older people...
April 21, 2017: Gerontology
https://www.readbyqxmd.com/read/28422306/development-of-a-novel-frailty-index-to-predict-mortality-in-patients-with-end-stage-liver-disease
#5
Jennifer C Lai, Kenneth E Covinsky, Jennifer L Dodge, W John Boscardin, Dorry L Segev, John P Roberts, Sandy Feng
BACKGROUND: Cirrhosis is characterized by muscle wasting, malnutrition, and functional decline that confer excess mortality not well quantified by the MELDNa score. We aimed to develop a frailty index to capture these extrahepatic complications of cirrhosis and enhance mortality prediction in cirrhotics. METHODS: Consecutive outpatients listed for LT at a single transplant center without MELD exceptions were assessed with candidate frailty measures. Best subset selection analyses with Cox regression identified subsets of frailty measures that predicted waitlist mortality (=death or delisting due to sickness)...
April 19, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28419668/prevalence-and-associated-variables-of-postdialysis-fatigue-results-of-a-prospective-multicenter-study
#6
Maurizio Bossola, Emanuele Marzetti, Enrico Di Stasio, Tania Monteburini, Stefano Cenerelli, Katia Mazzoli, Emanuele Parodi, Vittorio Sirolli, Stefano Santarelli, Fabio Ippoliti, Pier Eugenio Nebiolo, Mario Bonomini, Roberta Melatti, Carlo Vulpio
AIMS: Little is known about postdialysis fatigue (PDF), a debilitating symptom of hemodialysis patients. METHODS: In 5 hemodialysis units of northern-centre Italy, patients were regarded to suffer from PDF if they spontaneously offered this complaint when asked the open-ended question: Do you feel better or worse after dialysis? If worse, please specify in which way. A complaint of fatigue would be probed further with questions directed at its duration, frequency and intensity, allowing creation of a fatigue index of severity (one third of the sum of these three parameters, each rated from 1 to 5)...
April 17, 2017: Nephrology
https://www.readbyqxmd.com/read/28415035/serum-high-density-lipoprotein-cholesterol-concentration-and-functional-state-the-korean-urban-rural-elderly-kure-study
#7
Hansol Choi, Hyeon Chang Kim, Katherine M Stefani, Ju-Mi Lee, Young Mi Yoon, Eun Young Lee, Kyoung Min Kim, Yumie Rhee, Yoosik Youm, Chang Oh Kim
BACKGROUND: Functional state and cholesterol metabolism are important for older adults; however, this association has not been fully investigated among community-dwelling older adults. Thus, we investigated the association of HDL cholesterol with multiple functional state measures in an elderly Korean population. METHODS: This cross-sectional analysis included 3514 participants, aged 65 years or older, who participated in baseline health assessment for the Korean Urban Rural Elderly cohort study from 2012 to 2015...
April 7, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28408941/clinical-evaluation-of-acupuncture-as-treatment-for-complications-of-cerebrovascular-accidents-a-randomized-sham-controlled-subject-and-assessor-blind-trial
#8
Hsien-Yin Liao, Wen-Chao Ho, Chun-Chung Chen, Jaung-Geng Lin, Chia-Chi Chang, Liang-Yu Chen, De-Chih Lee, Yu-Chen Lee
Background and Purpose. The effect of acupuncture as treatment for poststroke complications is questionable. We performed a randomized, sham-controlled double-blind study to investigate it. Methods. Patients with first-time acute stroke were randomized to receive 24 sessions of either real or sham acupuncture during an eight-week period. The primary outcome measure was change in National Institute of Health Stroke Scale (NIHSS) score. Secondary outcome measures included changes in Barthel Index (BI), Instrumental Activities of Daily Living (IADL), Hamilton Depression Rating Scale (HAM-D), and Visual Analogue Scale (VAS) for pain scores...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28407806/development-and-validation-of-classifiers-and-variable-subsets-for-predicting-nursing-home-admission
#9
Mikko Nuutinen, Riikka-Leena Leskelä, Ella Suojalehto, Anniina Tirronen, Vesa Komssi
BACKGROUND: In previous years a substantial number of studies have identified statistically important predictors of nursing home admission (NHA). However, as far as we know, the analyses have been done at the population-level. No prior research has analysed the prediction accuracy of a NHA model for individuals. METHODS: This study is an analysis of 3056 longer-term home care customers in the city of Tampere, Finland. Data were collected from the records of social and health service usage and RAI-HC (Resident Assessment Instrument - Home Care) assessment system during January 2011 and September 2015...
April 13, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28402421/changes-over-time-in-the-health-and-functioning-of-older-people-moving-into-care-homes-analysis-of-data-from-the-english-longitudinal-study-of-ageing
#10
Isabel Green, Daniel Stow, Fiona E Matthews, Barbara Hanratty
Background: the number of people requiring care home support is projected to rise in future years, but little information is available on the needs of new care home residents. Objective: to measure the health and functioning of people moving into care homes and how they have changed between 2002 and 2015. Setting: English Longitudinal Study of Ageing. Participants: two hundred fifty-four of the 313 (1.99%) individuals who moved from the community into a care home, and were interviewed in the survey wave prior to entry...
April 10, 2017: Age and Ageing
https://www.readbyqxmd.com/read/28402165/statistical-properties-of-continuous-composite-scales-and-implications-for-drug-development
#11
Hong Liu-Seifert, Scott Andersen, Michael Case, JonDavid Sparks, Karen C Holdridge, Alette M Wessels, Suzanne Hendrix, Paul Aisen, Eric Siemers
Little research has been conducted on the statistical properties of composite measures comprising linear combinations of continuous component scales. We assessed the quantitative relationship between the composites and their individual components regarding their abilities to detect treatment effects. In particular, we developed the mathematical derivation of the treatment effect size of a continuous composite in relation to the treatment effect sizes of its components and proved multiple properties of the composite...
April 12, 2017: Journal of Biopharmaceutical Statistics
https://www.readbyqxmd.com/read/28392062/grefon-recommendations-for-assessment-of-instrumental-activities-of-daily-living-in-memory-clinics
#12
REVIEW
E Magnin, L Hugonot-Diener, J De Rotrou, C Machado, S Benisty, B Dieudonné, D Marchal, M Laure Strub, M Verny
Following a review of the available assessment scales and current practices of evaluation of instrumental activities of daily living (IADL) in French memory centres by GREFON (Groupe de réflexion sur l'évaluation fonctionnelle; Working Group on Functional Assessment), the main aim of this position paper was to provide good clinical practice (GCP) guidelines for the assessment of IADL. Another aim was to highlight the need for innovative tools adapted to the present and future evolution of such activities in real life, including the use of new technologies, the need for earlier detection of IADL impairment during the diagnostic process of mild neurocognitive disorders, and greater sensitivity to IADL changes during follow-up to allow adaptation of clinical management and evaluation of the impact of therapeutic interventions...
April 6, 2017: Revue Neurologique
https://www.readbyqxmd.com/read/28381510/physical-activity-but-not-body-mass-index-predicts-less-disability-before-and-after-stroke
#13
Pamela M Rist, Benjamin D Capistrant, Elizabeth Rose Mayeda, Sze Y Liu, M Maria Glymour
OBJECTIVE: To determine whether physical activity and body mass index (BMI) predict instrumental or basic activities of daily living (I/ADL) trajectories before or after stroke compared to individuals who remained stroke-free. METHODS: Using a prospective cohort, the Health and Retirement Study, we followed adults without a history of stroke in 1998 (n = 18,117) for up to 14 years. We estimated linear regression models of I/ADL trajectories comparing individuals who remained stroke-free throughout follow-up (n = 16,264), those who survived stroke (n = 1,374), and those who died after stroke and before the next interview wave (n = 479)...
April 5, 2017: Neurology
https://www.readbyqxmd.com/read/28379425/later-life-disability-in-environmental-context-why-living-arrangements-matter
#14
Carrie Henning-Smith, Tetyana Shippee, Benjamin Capistrant
Background and Objectives: Household social and environmental context are key elements of the disablement process, yet few studies explicitly examine the relationship between household composition, housing type, and disability progression. This study investigates the risk of older adults' disability progression by type of living arrangement (e.g., household composition, housing type) and whether the relationship varies by socioeconomic status. Research Design and Methods: We used Health and Retirement Study data (waves 1998-2012; n = 41,467 total observations) and fit time-series logistic regression models to estimate increases in activities of daily living (ADLs) and instrumental activities of daily living (IADLs) limitations...
April 3, 2017: Gerontologist
https://www.readbyqxmd.com/read/28372331/biomarkers-and-functional-decline-in%C3%A2-prodromal-alzheimer-s-disease
#15
Catherine Robb, Chinedu Udeh-Momoh, Stefan Wagenpfeil, Jakob Schöpe, Panagiotis Alexopoulos, Robert Perneczky
BACKGROUND: Little is known of possible associations between Alzheimer's disease (AD) biomarkers and instrumental activities of daily living (IADL) change over time. OBJECTIVE: The present study seeks to identify relationships between baseline imaging and fluid biomarker profiles, and decline in IADL utilizing data collated from the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort. METHODS: Generalized estimating equations analysis, adjusted for cognitive deterioration, was applied to a cohort of 509 individuals from all stages of ADNI, including 156 healthy controls, 189 early mild cognitive impairment (MCI) patients and 164 MCI patients...
March 29, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28369402/disability-among-middle-aged-and-older-persons-with-hiv-infection
#16
Nikolas A Johs, Kunling Wu, Katherine Tassiopoulos, Susan L Koletar, Robert C Kalayjian, Ronald J Ellis, Babafemi Taiwo, Frank J Palella, Kristine M Erlandson
Objective: Older HIV-infected adults may experience higher rates of frailty and disability than the general population. Improved understanding of the prevalence, risk factors, and types of impairment can better inform providers and the healthcare system. Methods: This was an observational study of HIV-infected participants within the ACTG A5322 HAILO study with self-reported disability by the Lawton-Brody Instrumental Activities of Daily Living (IADL) Questionnaire and frailty, measured by 4-m walk time, grip strength, self-reported weight loss, exhaustion, and low activity...
March 27, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28346565/anticholinergic-burden-and-functional-status-in-older-people-with-cognitive-impairment-results-from-the-regal-project
#17
V Boccardi, M Baroni, L Paolacci, S Ercolani, A Longo, M Giordano, C Ruggiero, P Mecocci
OBJECTIVE: The use of drugs with intrinsic anticholinergic properties is widespread among old age persons. A growing body of evidences suggest that a high anticholinergic burden is associated with physical and cognitive impairment. However, the association between anticholinergic drug use and functional status is still poorly investigated, particularly among subjects with initial cognitive impairment. DESIGN: Cross-sectional study examining the association between drug-related anticholinergic burden and functional status in cognitively healthy (CH) (n=691), mild cognitive impairment (MCI) (n=541) or mild Alzheimer's diseases (AD) (n=1127) subjects...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28346562/joint-association-of-obesity-and-hypertension-with-disability-in-the-elderly-a-community-based-study-of-residents-in-shanghai-china
#18
P Su, H Ding, W Zhang, G Duan, Y Yang, J Long, L Du, C Xie, C Jin, C Hu, Z Sun, Z Duan, L Gong, W Tian
BACKGROUND: Although both obesity and hypertension are known risk factors for disability, the joint association of obesity and hypertension with risk of disability is unknown. This paper is aim to examine the joint association of obesity and hypertension with risk of disability. METHODS: Cross-sectional study with 8060 elderly community-dwelling individuals participating in the survey initiated by Shanghai Health and Family Planning Commission from March to September 2013...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28336265/brain-structural-markers-and-caregiving-characteristics-as-interacting-correlates-of-caregiving-strain
#19
Stephen F Smagula, Scott Beach, Andrea L Rosso, Anne B Newman, Richard Schulz
OBJECTIVE: To evaluate the association between brain structural markers and caregiving strain among older informal caregivers. DESIGN: A secondary data analysis combining data from the Caregiver Health Effects Study (1993-1994) and the Cardiovascular Health Study MRI examination (1992-1994). SETTING: Four United States communities. PARTICIPANTS: Co-residing spousal caregivers (N = 237; mean age: 76.2 years, SD: 2...
February 21, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28330581/functional-decline-in-older-patients-with-cancer-receiving-chemotherapy-a-multicenter-prospective-study
#20
Cindy Kenis, Lore Decoster, Julie Bastin, Hannelore Bode, Katrien Van Puyvelde, Jacques De Grève, Godelieve Conings, Katleen Fagard, Johan Flamaing, Koen Milisen, Jean-Pierre Lobelle, Hans Wildiers
OBJECTIVES: This study aims to evaluate the evolution of functional status (FS) 2 to 3months after initiation of chemotherapy, to identify factors associated with functional decline during chemotherapy treatment and to investigate the prognostic value of functional decline for overall survival (OS). PATIENTS AND METHODS: Patients ≥70years with a malignant tumor were included when chemotherapy was initiated. All patients underwent a geriatric assessment (GA) including FS measured by Activities of Daily Living (ADL) and Instrumental Activities of Daily Living (IADL)...
March 15, 2017: Journal of Geriatric Oncology
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