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https://www.readbyqxmd.com/read/28651409/-drug-susceptibility-test-guided-therapy-and-novel-empirical-quadruple-therapy-for-helicobacter-pylori-infection-a-network-meta-analysis
#1
Q Y Gou, R B Yu, R H Shi
Objective: To compare the efficacy and the risk of adverse effect of drug susceptibility test guided therapy and novel empirical quadruple therapy for Helicobacter (H.) pylori infection. Methods: Literature retrieval was conducted by using major databases. Related papers published up to June 2015 were considered eligible if they were randomized control trials comparing different pharmacological formulations for H. pylori infection and used in a network Meta-analysis and a single rate Meta-analysis to evaluate the relative and absolute rates of H...
May 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28651352/circular-rna-profiling-reveals-that-circular-rnas-from-anxa2-can-be-used-as-new-biomarkers-for-multiple-sclerosis
#2
Iparraguirre Leire, Muñoz-Culla Maider, Prada Iñigo, Castillo-Triviño Tamara, Olascoaga Javier, Otaegui David
Multiple Sclerosis is an autoimmune disease, with higher prevalence in women, in whom the immune system is dysregulated. This dysregulation has been shown to correlate with changes in transcriptome expression as well as in gene-expression regulators, such as non-coding RNAs (e.g. microRNAs). Indeed, some of these have been suggested as biomarkers for multiple sclerosis even though few biomarkers have reached the clinical practice.Recently, a novel family of non-coding RNAs, circular RNAs, has emerged as a new player in the complex network of gene-expression regulation...
June 23, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28651222/assessing-habitat-quality-in-relation-to-the-spatial-distribution-of-protected-areas-in-italy
#3
Lorenzo Sallustio, Andrea De Toni, Andrea Strollo, Mirko Di Febbraro, Elena Gissi, Laura Casella, Davide Geneletti, Michele Munafò, Matteo Vizzarri, Marco Marchetti
The conservation of species and habitats is increasingly threatened by anthropogenic impacts, particularly land use change, from local to global scales. Although many efforts have been carried out so far to halt or at least reduce the biodiversity loss (e.g., the establishment of protected areas' networks), there are still both knowledge and policy gaps slowing the conservation of species and habitats in complex environments, such as the Mediterranean region. In particular, the human-driven impacts and threats on biodiversity need more careful analysis...
June 23, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28651217/modeling-in-sewer-transformations-at-catchment-scale-implications-on-drug-consumption-estimates-in-wastewater-based-epidemiology
#4
Ann-Kathrin McCall, Rocco Palmitessa, Frank Blumensaat, Eberhard Morgenroth, Christoph Ort
To which extent illicit drugs are transformed during in-sewer transport, depends on a number of factors: i) substance-specific transformation rates, ii) environmental conditions, iii) point of discharge (location of drug user) and iv) sewer network properties, primarily hydraulic residence time (HRT) and the ratio of biofilm contact area to wastewater volume (A/Veq). Assessing associated uncertainties typically requires numerous simulations. Therefore, we propose a new two-step modeling framework: 1) Quantify hydrodynamic conditions...
May 20, 2017: Water Research
https://www.readbyqxmd.com/read/28651183/investigating-the-effect-of-different-transducer-stiffness-values-on-the-contactin-complex-detachment-by-steered-molecular-dynamics
#5
Parnian Kianfar, Nabiollah Abolfathi, Navid Zarif Karimi
This study investigated the adhesion behavior of Contactin4 (CNTN4), a member of Immunoglobulin Super Family (Ig-SF) of cell adhesion molecules. Contactin4 plays a crucial role in the formation, maintenance, and plasticity of neuronal networks. Contactin in its complex configuration with protein tyrosine phosphatase gamma (PTPRG) was selected for simulation. By utilizing Steered Molecular Dynamics (SMD), the uniaxial force was applied to induce unbinding of the complex, and the force-induced detachment of complex components was probed...
June 2, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28651098/an-interoceptive-model-of-bulimia-nervosa-a-neurobiological-systematic-review
#6
REVIEW
Megan Klabunde, Danielle Collado, Cara Bohon
The objective of our study was to examine the neurobiological support for an interoceptive sensory processing model of bulimia nervosa (BN). To do so, we conducted a systematic review of interoceptive sensory processing in BN, using the PRISMA guidelines. We searched PsychInfo, Pubmed, and Web of Knowledge databases to identify biological and behavioral studies that examine interoceptive detection in BN. After screening 390 articles for inclusion and conducting a quality assessment of articles that met inclusion criteria, we reviewed 41 articles...
June 19, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28651066/thalassemia-major-transfusion-and-chelation-or-transplantation
#7
REVIEW
Said Yousuf Mohamed
Thalassemia is the most common monogenic hematologic disease that affects millions in the world and kills thousands of patients every year. Without transfusion or transplantation, patients with thalassemia major are expected to die within months of diagnosis. However, long-term transfusion and chelation therapy is highly challenging for many developing countries where the disease is prevalent, representing a major and unsustainable health burden. Stem cell transplantation is the only cure for thalassemia. It has witnessed major developments that have made it less toxic, more successful, and feasible for a larger number of patients with diverse comorbidities and from a wider range of donors...
June 20, 2017: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/28651018/meta-analysis-of-mirna-expression-profiles-for-prostate-cancer-recurrence-following-radical-prostatectomy
#8
Elnaz Pashaei, Elham Pashaei, Maryam Ahmady, Mustafa Ozen, Nizamettin Aydin
BACKGROUND: Prostate cancer (PCa) is a leading reason of death in men and the most diagnosed malignancies in the western countries at the present time. After radical prostatectomy (RP), nearly 30% of men develop clinical recurrence with high serum prostate-specific antigen levels. An important challenge in PCa research is to identify effective predictors of tumor recurrence. The molecular alterations in microRNAs are associated with PCa initiation and progression. Several miRNA microarray studies have been conducted in recurrence PCa, but the results vary among different studies...
2017: PloS One
https://www.readbyqxmd.com/read/28651014/a-decade-of-haart-in-latin-america-long-term-outcomes-among-the-first-wave-of-hiv-patients-to-receive-combination-therapy
#9
Marcelo J Wolff, Mark J Giganti, Claudia P Cortes, Pedro Cahn, Beatriz Grinsztejn, Jean W Pape, Denis Padgett, Juan Sierra-Madero, Eduardo Gotuzzo, Stephany N Duda, Catherine C McGowan, Bryan E Shepherd
BACKGROUND: In Latin America, the first wave of HIV-infected patients initiated highly active antiretroviral therapy (HAART) 10 or more years ago. Characterizing their treatment experience and corresponding outcomes across a decade of HAART may yield insights relevant to the ongoing care of such patients and those initiating HAART more recently in similar clinical settings. METHODS: This retrospective study included adults initiating HAART before 2004 at 8 sites in Argentina, Brazil, Chile, Haiti, Honduras, and Mexico...
2017: PloS One
https://www.readbyqxmd.com/read/28650998/functional-annotation-of-alzheimer-s-disease-associated-loci-revealed-by-gwass
#10
Zengpeng Han, Han Huang, Yue Gao, Qingyang Huang
Genome-wide association studies (GWASs) discovered a number of SNPs and genes associated with Alzheimer's disease (AD). However, how these SNPs and genes influence the liability to AD is not fully understood. We deployed computational approaches to explore the function and action mechanisms of AD -related SNPs and genes identified by GWASs, including the effects of 195 GWAS lead SNPs and 338 proxy SNPs on miRNAs binding and protein phosphorylation, their RegulomeDB and 3DSNP scores, and gene ontology, pathway enrichment and protein-protein interaction network of 126 AD-associated genes...
2017: PloS One
https://www.readbyqxmd.com/read/28650994/abnormal-global-functional-network-connectivity-and-its-relationship-to-medial-temporal-atrophy-in-patients-with-amnestic-mild-cognitive-impairment
#11
Can Sheng, Mingrui Xia, Haikuo Yu, Yue Huang, Yan Lu, Fang Liu, Yong He, Ying Han
BACKGROUND: Amnestic mild cognitive impairment (aMCI), which is recently considered as a high risk status for developing Alzheimer's disease (AD), manifests with gray matter atrophy and increased focal functional activity in the medial temporal lobe (MTL). However, the abnormalities of whole-brain functional network connectivity in aMCI and its relationship to medial temporal atrophy (MTA) remain unknown. METHODS: In this study, thirty-six aMCI patients and thirty-five healthy controls (HCs) were recruited...
2017: PloS One
https://www.readbyqxmd.com/read/28650974/resting-state-electrical-brain-activity-and-connectivity-in-fibromyalgia
#12
Sven Vanneste, Jan Ost, Tony Van Havenbergh, Dirk De Ridder
The exact mechanism underlying fibromyalgia is unknown, but increased facilitatory modulation and/or dysfunctional descending inhibitory pathway activity are posited as possible mechanisms contributing to sensitization of the central nervous system. The primary goal of this study is to identify a fibromyalgia neural circuit that can account for these abnormalities in central pain. The second goal is to gain a better understanding of the functional connectivity between the default and the executive attention network (salience network plus dorsal lateral prefrontal cortex) in fibromyalgia...
2017: PloS One
https://www.readbyqxmd.com/read/28650955/netnorm-capturing-cancer-relevant-information-in-somatic-exome-mutation-data-with-gene-networks-for-cancer-stratification-and-prognosis
#13
Marine Le Morvan, Andrei Zinovyev, Jean-Philippe Vert
Genome-wide somatic mutation profiles of tumours can now be assessed efficiently and promise to move precision medicine forward. Statistical analysis of mutation profiles is however challenging due to the low frequency of most mutations, the varying mutation rates across tumours, and the presence of a majority of passenger events that hide the contribution of driver events. Here we propose a method, NetNorM, to represent whole-exome somatic mutation data in a form that enhances cancer-relevant information using a gene network as background knowledge...
June 26, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28650922/randomized-trial-of-reducing-ambulatory-malpractice-and-safety-risk-results-of-the-massachusetts-promises-project
#14
Gordon D Schiff, Harry Reyes Nieva, Paula Griswold, Nicholas Leydon, Judy Ling, Frank Federico, Carol Keohane, Bonnie R Ellis, Cathy Foskett, E John Orav, Catherine Yoon, Don Goldmann, Joel S Weissman, David W Bates, Madeleine Biondolillo, Sara J Singer
OBJECTIVE: Evaluate application of quality improvement approaches to key ambulatory malpractice risk and safety areas. STUDY SETTING: In total, 25 small-to-medium-sized primary care practices (16 intervention; 9 control) in Massachusetts. STUDY DESIGN: Controlled trial of a 15-month intervention including exposure to a learning network, webinars, face-to-face meetings, and coaching by improvement advisors targeting "3+1" high-risk domains: test result, referral, and medication management plus culture/communication issues evaluated by survey and chart review tools...
June 23, 2017: Medical Care
https://www.readbyqxmd.com/read/28650915/the-brainstem-network-controlling-blood-pressure-an-important-role-for-pressor-sites-in-the-caudal-medulla-and-cervical-spinal-cord
#15
Michael G Z Ghali
: Although medullary control of blood pressure (BP) has been extensively studied, the contribution of critical regions, such as pressor sites in the caudal medulla and upper cervical spinal cord and the lateral tegmental field, remains controversial and underappreciated. A series of pressor sites caudal to the caudal ventrolateral medulla (CVLM), including the caudal pressor area (CPA) and medullocervical pressor area, play an important role in control of BP. Activation and inhibition of these sites elicits pressor and depressor responses, respectively...
June 24, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28650896/development-and-validation-of-a-quantitative-measure-of-adaptive-behaviors-in-women-with-pelvic-floor-disorders
#16
John T Wei, Rodney Dunn, Ingrid Nygaard, Kathryn Burgio, Emily S Lukacz, Alayne Markland, Patricia A Wren, Linda Brubaker, Matthew D Barber, J Eric Jelovsek, Cathie Spino, Susie Meikle, Nancy Janz
PURPOSE: To establish validity for the Pelvic Floor Disorders Network (PFDN) self-administered Adaptive Behavior Index (ABI) and to assess whether ABI assesses known discordance between severity of pelvic floor symptoms and self-reported bother. METHODS: In addition to the ABI questionnaire, participants in 1 of 6 Pelvic Floor Disorders Network trials completed condition-specific measures of pretreatment symptom severity (including Pelvic Floor Distress Inventory; PFDI) and health-related quality of life (Pelvic Floor Impact Questionnaire; PFIQ)...
July 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/28650838/adaptive-neural-network-finite-time-output-feedback-control-of-quantized-nonlinear-systems
#17
Fang Wang, Bing Chen, Chong Lin, Jing Zhang, Xinzhu Meng
This paper addresses the finite-time tracking issue for nonlinear quantized systems with unmeasurable states. Compared with the existing researches, the finite-time quantized feedback control is considered for the first time. By proposing a new finite-time stability criterion and designing a state observer, a novel adaptive neural output-feedback control strategy is raised by backstepping technique. Under the presented control scheme, the finite-time quantized feedback control problem is coped with without limiting assumption for nonlinear functions...
June 26, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28650833/exponential-stabilization-of-memristive-neural-networks-via-saturating-sampled-data-control
#18
Sanbo Ding, Zhanshan Wang, Nannan Rong, Huaguang Zhang
This paper is concerned with the exponential stabilization of memristive neural networks (MNNs) by taking into account the sampled-data control and actuator saturation. On the one hand, the MNNs are converted into a tractable model by defining a class of logical switched functions. Based on this model, the connection weights of MNNs are dealt with by a robust analysis method. On the other hand, a saturating sampled-data controller containing an exponentially decaying term is designed. With the help of generalized sector condition and the Lyapunov stability theory, a novel sufficient condition ensuring the local exponential stability of the closed-loop systems is formulated in terms of linear matrix inequalities...
June 22, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28650827/neural-decomposition-of-time-series-data-for-effective-generalization
#19
Luke B Godfrey, Michael S Gashler
We present a neural network technique for the analysis and extrapolation of time-series data called neural decomposition (ND). Units with a sinusoidal activation function are used to perform a Fourier-like decomposition of training samples into a sum of sinusoids, augmented by units with nonperiodic activation functions to capture linear trends and other nonperiodic components. We show how careful weight initialization can be combined with regularization to form a simple model that generalizes well. Our method generalizes effectively on the Mackey-Glass series, a data set of unemployment rates as reported by the U...
June 22, 2017: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/28650826/delayed-feedback-control-for-stabilization-of-boolean-control-networks-with-state-delay
#20
Rongjian Liu, Jianquan Lu, Yang Liu, Jinde Cao, Zheng-Guang Wu
In this brief, we study the delayed feedback stabilization problem for Boolean control networks (BCNs) with state delay. Using the semi-tensor product of matrices, some necessary and sufficient conditions are obtained. For the stabilization of BCNs, detailed procedure to construct the feedback controllers is also presented. We further derive the number of different feedback controllers, which can successfully stabilize the BCN in a finite time. Finally, an illustrative example is presented to show the effectiveness of our method...
June 22, 2017: IEEE Transactions on Neural Networks and Learning Systems
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