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https://www.readbyqxmd.com/read/28536837/controlled-sedation-with-midazolam-and-analgesia-with-nalbuphine-to-alleviate-pain-in-patients-undergoing-subcutaneous-implantable-cardioverter-defibrillator-implantation
#1
Michaël Peyrol, Jérémie Barraud, Jennifer Cautela, Baptiste Maille, Marc Laine, Laurent Bonello, Franck Thuny, Franck Paganelli, Frédéric Franceschi, Linda Koutbi, Samuel Levy
PURPOSE: Subcutaneous implantable cardioverter defibrillator (S-ICD) is an alternative to transvenous ICD to prevent sudden cardiac death. Subcutaneous ICD implantation frequently requires general anesthesia because of procedure nociceptive steps during creation of a large device pocket and lead tunneling. This study aims to determine if a strategy of operator-guided controlled sedation with midazolam and analgesia with nalbuphine is effective in alleviating pain during S-ICD implantation...
May 23, 2017: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/28532895/motivational-interviewing-to-promote-oral-health-in-adolescents
#2
Lingli Wu, Xiaoli Gao, Edward C M Lo, Samuel M Y Ho, Colman McGrath, May C M Wong
PURPOSE: Motivational interviewing (MI) is a counseling strategy to help people change their behaviors. This single-blinded randomized controlled trial evaluated the effectiveness of MI in improving adolescents' oral health. METHODS: Fifteen secondary schools were randomly assigned to three groups: (I) prevailing health education, (II) MI, and (III) MI coupled with interactive dental caries risk assessment (MI + RA). Adolescents (n = 512) with unfavorable oral health behaviors (infrequent toothbrushing and/or frequent snacking) were recruited; 161, 163, and 188 in groups I-III, respectively...
May 19, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28526489/intravitreous-injection-of-aav2-sflt01-in-patients-with-advanced-neovascular-age-related-macular-degeneration-a-phase-1-open-label-trial
#3
Jeffrey S Heier, Saleema Kherani, Shilpa Desai, Pravin Dugel, Shalesh Kaushal, Seng H Cheng, Cheryl Delacono, Annie Purvis, Susan Richards, Annaig Le-Halpere, John Connelly, Samuel C Wadsworth, Rafael Varona, Ronald Buggage, Abraham Scaria, Peter A Campochiaro
BACKGROUND: Long-term intraocular injections of vascular endothelial growth factor (VEGF)-neutralising proteins can preserve central vision in many patients with neovascular age-related macular degeneration. We tested the safety and tolerability of a single intravitreous injection of an AAV2 vector expressing the VEGF-neutralising protein sFLT01 in patients with advanced neovascular age-related macular degeneration. METHODS: This was a phase 1, open-label, dose-escalating study done at four outpatient retina clinics in the USA...
May 16, 2017: Lancet
https://www.readbyqxmd.com/read/28521024/pipeline-embolization-device-for-pericallosal-artery-aneurysms-a-retrospective-single-center-safety-and-efficacy-study
#4
Katyucia De Macedo Rodrigues, Anna Luisa Kühn, Takamitsu Tamura, Guilherme Dabus, Peter Kan, Miklos G Marosfoi, J Diego Lozano, Mary Perras, Christopher Brooks, Mary C Howk, Samuel Y Hou, David E Rex, Francesco Massari, Matthew J Gounis, Ajay K Wakhloo, Ajit S Puri
BACKGROUND: Pericallosal artery aneurysm treatment may be challenging using traditional endovascular techniques. OBJECTIVE: To demonstrate the feasibility, efficacy, and safety of endovascular treatment of pericallosal artery aneurysm using flow diverters. METHODS: We performed a retrospective review of our institutional database from July 2013 through July 2016 and identified 7 subjects with a pericallosal artery aneurysm treated with the Pipeline embolization device (ev3 Neurovascular, Medtronic, Dublin, Ireland) and at least 1 follow-up angiogram...
May 17, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28510626/outcome-measures-for-clinical-trials-of-leber-congenital-amaurosis-caused-by-the-intronic-mutation-in-the-cep290-gene
#5
Samuel G Jacobson, Artur V Cideciyan, Alexander Sumaroka, Alejandro J Roman, Jason Charng, Monica Lu, Windy Choi, Rebecca Sheplock, Malgorzata Swider, Mychajlo S Kosyk, Sharon B Schwartz, Edwin M Stone, Gerald A Fishman
Purpose: To determine efficacy outcome measures for clinical trials of Leber congenital amaurosis (LCA) associated with a common intronic mutation in the CEP290 gene. Methods: CEP290-LCA patients (ages 5-48) with the intronic mutation (c.2991+1655A>G) were studied as a retrospective observational case series using clinical methods and with full-field sensitivity testing (FST), optical coherence tomography (OCT), autofluorescence imaging (NIR-RAFI), transient pupillary light reflex (TPLR), oculomotor control and instability (OCI), a mobility course, and a questionnaire (NEI-VFQ)...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28506611/clinical-and-genetic-associations-of-objectively-identified-interstitial-changes-in-smokers
#6
Samuel Y Ash, Rola Harmouche, Rachel K Putman, James C Ross, Alejandro A Diaz, Gary M Hunninghake, Jorge Onieva Onieva, Fernando J Martinez, Augustine M Choi, David A Lynch, Hiroto Hatabu, Ivan O Rosas, Raul San Jose Estepar, George R Washko
BACKGROUND: Smoking related lung injury may manifest on computed tomography (CT) as both emphysema and interstitial changes. We have developed an automated method to quantify interstitial changes and hypothesized that this measurement would be associated with lung function, quality of life, mortality, and a MUC5B polymorphism. METHODS: Using CT scans from the COPDGene study, lung parenchyma was objectively labeled as a tissue subtype and the percentage of the lung occupied by interstitial subtypes was calculated...
May 12, 2017: Chest
https://www.readbyqxmd.com/read/28504993/red-blood-cell-transfusion-and-surgical-site-infection-after-colon-resection-surgery-a-cohort-study
#7
Michael Mazzeffi, Kenichi Tanaka, Samuel Galvagno
BACKGROUND: Surgical site infections (SSIs) after colon surgery remain a critical safety issue. Patients with an SSI have an increased risk of death, prolonged hospitalization, and increased costs of care. Red blood cell (RBC) transfusion is given during the perioperative period to increase blood oxygen delivery, but it is associated with complications, including infection. We hypothesized that RBC transfusion would be associated with increased SSI risk in patients undergoing colon resection surgery...
May 11, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28495424/clinical-and-radiographic-outcomes-following-hinge-fracture-during-open-door-cervical-laminoplasty
#8
Dong-Ho Lee, Hyoungmin Kim, Choon Sung Lee, Chang-Ju Hwang, Jae-Hwan Cho, Samuel K Cho
To investigate the clinical and radiographic fate of fractured hinges in open-door cervical laminoplasty, 135 segments of 36 patients who had undergone follow-up for more than two years after open-door cervical laminoplasty due to compressive cervical myelopathy were reviewed clinically and radiographically. Hinge fractures were identified by the intraoperative finding of obvious instability or click sounds (an obvious fracture), or by immediate postoperative computed tomography (CT) images showing a discontinuity of both the inner and outer cortex or a displacement of more than 1mm at the lamina hinge site (an occult fracture)...
May 8, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28492210/predictors-of-quality-of-life-in-patients-with-diabetes-mellitus-in-two-tertiary-health-institutions-in-ghana-and-nigeria
#9
Grace K Ababio, Samuel Bosomprah, Adesola Olumide, Nicholas Aperkor, Chris Aimakhu, Audrey Oteng-Yeboah, Joan Agama, William F Chaplin, Kola S Okuyemi, Albert G B Amoah, Gbenga Ogedegbe
BACKGROUND: Patients with chronic diseases such as Type 2 diabetes mellitus (DM) usually have a relatively poor quality of life (QoL), because the cost of care (living expenses and health) or diet restrictions are heavily felt by these patients, and this is of a public health concern. However, limited data on DM QoL exist in Ghana and Nigeria. This makes it imperative for data to be collated in that regard. MATERIALS AND METHODS: We adopted the Strengthening The reporting of observational studies in epidemiology (STROBE) consensus checklist to survey the patients with DM seen at the diabetic clinic at the Department of Medicine of the Korle-Bu Teaching Hospital and University College Hospital, Ibadan, Nigeria...
January 2017: Nigerian Postgraduate Medical Journal
https://www.readbyqxmd.com/read/28492209/some-characteristics-of-gliomas-managed-at-a-neurosurgery-centre-in-nigeria
#10
Chika A Ndubuisi, Samuel C Ohaegbulam, Mark O Chikani, Wilfred C Mezue, Tobechi Mbadugha, Mark Okhueleigbe
BACKGROUND: Gliomas are important primary brain tumours with varying prognosis. AIM: To study the histology characteristics of brain gliomas managed in a Neurosurgical centre in Nigeria. MATERIALS AND METHODS: A retrospective analysis of prospectively recorded data of patients managed for intracranial gliomas at our Hospital for Neurosurgery, between year 2006 and 2015. Only the patients with conclusive histology diagnosis following surgery were analysed...
January 2017: Nigerian Postgraduate Medical Journal
https://www.readbyqxmd.com/read/28483212/predictors-and-functional-implications-of-change-in-leg-length-after%C3%A2-total-knee-arthroplasty
#11
Jason Chinnappa, Darren B Chen, Ian A Harris, Samuel J MacDessi
BACKGROUND: Leg lengthening occurs in 83% of primary total knee arthroplasty (TKA). The effects of leg length discrepancy (LLD) on THA patients are well established. However, patient function and satisfaction associated with LLD after primary TKA has not been analyzed. This study aimed to quantify the magnitude of limb lengthening, identify radiographic and perceived LLD, and correlate these with predictive factors and functional outcomes in a series of TKA patients. METHODS: Patients undergoing primary TKA who met inclusion criteria were prospectively enrolled in this study...
April 13, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28481670/family-quality-of-life-survey-fqols-2006-evaluation-of-internal-consistency-construct-and-criterion-validity-for-socioeconomically-disadvantaged-families
#12
Preethy S Samuel, Wassim Tarraf, Christina Marsack
AIMS: The purpose of this study was to test the psychometric properties of the Family Quality of Life Survey (FQOLS-2006) when used with urban families predominantly from socioeconomically disadvantaged backgrounds. METHODS: Data gathered from 193 family caregivers using the FQOLS-2006 were subjected to reliability analyses, confirmatory factor analyses, and correlational analyses to test the internal consistency of the scales (reliability), factor structure of the scales (construct validity), and convergence between the long and short versions of the tool (criterion validity)...
May 8, 2017: Physical & Occupational Therapy in Pediatrics
https://www.readbyqxmd.com/read/28481163/body-temperature-after-ems-transport-association-with-traumatic-brain-injury-outcomes
#13
Joshua B Gaither, Vatsal Chikani, Uwe Stolz, Chad Viscusi, Kurt Denninghoff, Bruce Barnhart, Terry Mullins, Amber D Rice, Moses Mhayamaguru, Jennifer J Smith, Samuel M Keim, Bentley J Bobrow, Daniel W Spaite
INTRODUCTION: Low body temperatures following prehospital transport are associated with poor outcomes in patients with traumatic brain injury (TBI). However, a minimal amount is known about potential associations across a range of temperatures obtained immediately after prehospital transport. Furthermore, a minimal amount is known about the influence of body temperature on non-mortality outcomes. The purpose of this study was to assess the correlation between temperatures obtained immediately following prehospital transport and TBI outcomes across the entire range of temperatures...
May 8, 2017: Prehospital Emergency Care
https://www.readbyqxmd.com/read/28480627/predicting-long-term-mortality-after-fontan-procedures-a-risk-score-based-on-6707-patients-from-28-studies
#14
Tarek Alsaied, Jouke P Bokma, Mark E Engel, Joey M Kuijpers, Samuel P Hanke, Liesl Zuhlke, Bin Zhang, Gruschen R Veldtman
BACKGROUND: Reported long-term outcome measures vary greatly between studies in Fontan patients making comprehensive appraisal of mortality hazard challenging. We sought to create a clinical risk score to assist monitoring of Fontan patients in the outpatient setting. METHODS: A systematic review was conducted to evaluate risk factors for long-term (beyond the first postoperative year) mortality in Fontan patients. Studies were eligible for inclusion if ≥90 patients were included or ≥20 long-term mortalities we reported...
May 8, 2017: Congenital Heart Disease
https://www.readbyqxmd.com/read/28461541/patient-and-family-experience-a-comparison-of-intensive-care-and-overall-hospitalization
#15
Soowhan Lah, Emily L Wilson, Ronen Rozenblum, Eliotte L Hirshberg, Ramona O Hopkins, James Orme, Samuel M Brown
BACKGROUND: The Hospital Consumer Assessment of Healthcare Providers and Systems survey is the most commonly used instrument for measuring patients' perceptions of the quality of inpatient care. OBJECTIVE: To determine if the hospital survey can also be used to measure patients' experience of intensive care as indicated by scores on a parallel questionnaire, the Patient Perception of Quality. METHODS: Scores on both instruments of all adult patients admitted to an intensive care unit from 2007 through 2012 were analyzed...
May 2017: American Journal of Critical Care: An Official Publication, American Association of Critical-Care Nurses
https://www.readbyqxmd.com/read/28461255/improved-overall-survival-with-aggressive-primary-tumor-radiotherapy-for-patients-with-metastatic-esophageal-cancer
#16
David M Guttmann, Nandita Mitra, Justin Bekelman, James M Metz, John Plastaras, Weiwei Feng, Samuel Swisher-McClure
OBJECTIVES: The aim of this study was to characterize utilization and survival outcomes associated with primary tumor-directed radiotherapy (PTDRT) in patients with newly diagnosed metastatic esophageal cancer. METHODS: We conducted an observational cohort study using the National Cancer Data Base to evaluate patients with newly diagnosed metastatic esophageal cancer between 2004 and 2012. Overall survival outcomes after treatment with chemotherapy plus conventional palliative dose radiotherapy (<5040 cGy), chemotherapy plus definitive dose radiotherapy (≥5040 cGy), or chemotherapy alone were compared by using Cox proportional hazards models with inverse probability of treatment weighting using the propensity score...
April 28, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28455181/discharge-to-inpatient-facilities-after-total-hip-arthroplasty-is-associated-with-increased-postdischarge-morbidity
#17
Michael C Fu, Andre M Samuel, Peter K Sculco, Catherine H MacLean, Douglas E Padgett, Alexander S McLawhorn
BACKGROUND: Discharge disposition accounts for significant variability in costs after elective total hip arthroplasty (THA). Therefore, institutions must evaluate the short-term clinical outcomes associated with postdischarge care options. The present study intends to characterize the associations between short-term morbidity after primary THA and discharge destination. METHODS: Primary elective unilateral THA cases performed for osteoarthritis were identified in the American College of Surgeons National Surgical Quality Improvement Program registry from 2011 to 2014...
March 27, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28451493/a-multicenter-study-of-the-presentation-treatment-and-outcomes-of-cervical-dural-tears
#18
Kevin R O'Neill, Michael G Fehlings, Thomas E Mroz, Zachary A Smith, Wellington K Hsu, Adam S Kanter, Michael P Steinmetz, Paul M Arnold, Praveen V Mummaneni, Dean Chou, Ahmad Nassr, Sheeraz A Qureshi, Samuel K Cho, Evan O Baird, Justin S Smith, Christopher Shaffrey, Chadi A Tannoury, Tony Tannoury, Ziya L Gokaslan, Jeffrey L Gum, Robert A Hart, Robert E Isaacs, Rick C Sasso, David B Bumpass, Mohamad Bydon, Mark Corriveau, Anthony F De Giacomo, Adeeb Derakhshan, Bruce C Jobse, Daniel Lubelski, Sungho Lee, Eric M Massicotte, Jonathan R Pace, Gabriel A Smith, Khoi D Than, K Daniel Riew
STUDY DESIGN: Retrospective multicenter case series study. OBJECTIVE: Because cervical dural tears are rare, most surgeons have limited experience with this complication. A multicenter study was performed to better understand the presentation, treatment, and outcomes following cervical dural tears. METHODS: Multiple surgeons from 23 institutions retrospectively identified 21 rare complications that occurred between 2005 and 2011, including unintentional cervical dural tears...
April 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28447399/genome-wide-association-study-of-hiv-associated-neurocognitive-disorder-hand-a-charter-group-study
#19
Peilin Jia, Zhongming Zhao, Todd Hulgan, William S Bush, David C Samuels, Cinnamon S Bloss, Robert K Heaton, Ronald J Ellis, Nicholas Schork, Christina M Marra, Ann C Collier, David B Clifford, Benjamin B Gelman, Ned Sacktor, Susan Morgello, David M Simpson, J Allen McCutchan, Jill S Barnholtz-Sloan, Donald R Franklin, Debralee Rosario, Scott L Letendre, Igor Grant, Asha R Kallianpur
HIV-associated neurocognitive disorder (HAND) often complicates HIV infection despite combination antiretroviral therapy (ART) and may be influenced by host genomics. We performed a genome-wide association study (GWAS) of HAND in 1,050 CNS HIV Anti-Retroviral Therapy Effects Research (CHARTER) Study participants. All participants underwent standardized, comprehensive neurocognitive, and neuromedical assessments to determine if they had cognitive impairment as assessed by the Global Deficit Score (GDS), and individuals with comorbidities that could confound diagnosis of HAND were excluded...
June 2017: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/28444118/development-and-evaluation-of-the-medication-based-index-of-physical-function-medip
#20
Courtney D Hall, Samuel C Karpen, Brian Odle, Peter C Panus, Zachary F Walls
Background: the development of an objective and comprehensive drug-based index of physical function for older adults has the potential to more accurately predict fall risk. Design: the index was developed using 862 adults (ages 57-85) from the National Social Life, Health, and Aging Project (NSHAP) Wave 1 study. The index was evaluated in 70 adults (ages 51-88) from a rehabilitation study of dizziness and balance. Methods: the prevalence among 601 drugs for 1,694 side effects was used with fall history to determine the magnitude of each side effect's contribution towards physical function...
April 24, 2017: Age and Ageing
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