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https://www.readbyqxmd.com/read/28326650/long-term-efficacy-of-constant-current-deep-brain-stimulation-in-essential-tremor
#1
Ali Rezaei Haddad, Michael Samuel, Natasha Hulse, Hsin-Ying Lin, Keyoumars Ashkan
OBJECTIVES: Ventralis intermedius deep brain stimulation is an established intervention for medication-refractory essential tremor. Newer constant current stimulation technology offers theoretical advantage over the traditional constant voltage systems in terms of delivering a more biologically stable therapy. There are no previous reports on the outcomes of constant current deep brain stimulation in the treatment of essential tremor. This study aimed to evaluate the long-term efficacy of ventralis intermedius constant current deep brain stimulation in patients diagnosed with essential tremor...
March 21, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28324062/gene-hormone-therapy-interaction-and-fracture-risk-in-postmenopausal-women
#2
Youjin Wang, Jean Wactawski-Wende, Lara E Sucheston-Campbell, Leah Preus, Kathleen M Hovey, Jing Nie, Rebecca D Jackson, Samuel K Handelman, Rami Nassir, Carolyn J Crandall, Heather M Ochs-Balcom
Context: Evidence supports a protective effect of menopausal hormone therapy (HT) on bone. However, whether genetic susceptibility modifies the association of HT and fracture risk is not sufficiently explored. Objective: The objective was to test an interaction between genetic susceptibility and HT on fracture risk. Design: We constructed two weighted genetic risk scores (GRSs) based on 16 fracture-associated variants (Fx-GRS) and 50 bone mineral density (BMD) variants (BMD-GRS)...
March 6, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28320601/coronary-atherosclerosis-in-indigenous-south-american-tsimane-a-cross-sectional-cohort-study
#3
Hillard Kaplan, Randall C Thompson, Benjamin C Trumble, L Samuel Wann, Adel H Allam, Bret Beheim, Bruno Frohlich, M Linda Sutherland, James D Sutherland, Jonathan Stieglitz, Daniel Eid Rodriguez, David E Michalik, Chris J Rowan, Guido P Lombardi, Ram Bedi, Angela R Garcia, James K Min, Jagat Narula, Caleb E Finch, Michael Gurven, Gregory S Thomas
BACKGROUND: Conventional coronary artery disease risk factors might potentially explain at least 90% of the attributable risk of coronary artery disease. To better understand the association between the pre-industrial lifestyle and low prevalence of coronary artery disease risk factors, we examined the Tsimane, a Bolivian population living a subsistence lifestyle of hunting, gathering, fishing, and farming with few cardiovascular risk factors, but high infectious inflammatory burden. METHODS: We did a cross-sectional cohort study including all individuals who self-identified as Tsimane and who were aged 40 years or older...
March 16, 2017: Lancet
https://www.readbyqxmd.com/read/28320597/racial-or-ethnic-and-socioeconomic-inequalities-in-adherence-to-national-dietary-guidance-in-a-large-cohort-of-us-pregnant-women
#4
Lisa M Bodnar, Hyagriv N Simhan, Corette B Parker, Heather Meier, Brian M Mercer, William A Grobman, David M Haas, Deborah A Wing, Matthew K Hoffman, Samuel Parry, Robert M Silver, George R Saade, Ronald Wapner, Jay D Iams, Pathik D Wadhwa, Michal Elovitz, Alan M Peaceman, Sean Esplin, Shannon Barnes, Uma M Reddy
BACKGROUND: The significance of periconceptional nutrition for optimizing offspring and maternal health and reducing social inequalities warrants greater understanding of diet quality among US women. OBJECTIVE: Our objective was to evaluate racial or ethnic and education inequalities in periconceptional diet quality and sources of energy and micronutrients. DESIGN: Cross-sectional analysis of data from the Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-Be cohort...
March 14, 2017: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/28301396/can-hyper-realistic-physical-models-of-peripheral-vessel-exposure-and-fasciotomy-replace-cadavers-for-performance-assessment
#5
Jeremy Holzmacher, Babak Sarani, Adam Puche, Guinevere Granite, Valerie Shalin, Kristy Pugh, William Teeter, Samuel Tisherman, Stacy Shackelford, Colin F Mackenzie
BACKGROUND: Work-hour restrictions have reduced operative experience for residents. The Advanced Surgical Skills for Exposure in Trauma course fills this training gap. Cadaver use has limitations including cost and availability. Hyper-realistic synthetic models may provide an alternative to cadavers. We compared same surgeon performance between synthetic and cadaveric models to determine interchangeability for formative evaluation. METHODS: 40 residents (<4wks after ASSET) and 35 faculty (mean 2...
March 15, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28293444/association-of-gait-characteristics-and-depression-in-patients-with-parkinson-s-disease-assessed-in-goal-directed-locomotion-task
#6
Péter Kincses, Norbert Kovács, Kázmér Karádi, Ádám Feldmann, Krisztina Dorn, Zsuzsanna Aschermann, Sámuel Komoly, Tibor Szolcsányi, Árpád Csathó, János Kállai
Introduction. In the genesis of Parkinson's disease (PD) clinical phenomenology the exact nature of the association between bradykinesia and affective variables is unclear. In the present study, we analyzed the gait characteristics and level of depression in PD and healthy volunteers. Methods. Patients with PD (n = 48) and healthy controls (n = 52) were recruited for the present study. Walking speed, stride length, and cadence were compared between groups while participants completed a goal-directed locomotion task under visually controlled (VC) and visually noncontrolled conditions (VnC)...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28293420/candidemia-in-a-major-regional-tertiary-referral-hospital-epidemiology-practice-patterns-and-outcomes
#7
Jocelyn Qi-Min Teo, Samuel Rocky Candra, Shannon Jing-Yi Lee, Shannon Yu-Hng Chia, Hui Leck, Ai-Ling Tan, Hui-Peng Neo, Kenneth Wei-Liang Leow, Yiying Cai, Rachel Pui-Lai Ee, Tze-Peng Lim, Winnie Lee, Andrea Lay-Hoon Kwa
BACKGROUND: Candidemia is a common cause of nosocomial bloodstream infections, resulting in high morbidity and mortality. This study was conducted to describe the epidemiology, species distribution, antifungal susceptibility patterns and outcomes of candidemia in a large regional tertiary referral hospital. METHODS: A retrospective surveillance study of patients with candidemia was conducted at Singapore General Hospital between July 2012 and December 2015. In addition, incidence densities and species distribution of candidemia episodes were analysed from 2008 to 2015...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/28290730/qualitative-video-analysis-of-track-cycling-team-pursuit-in-world-class-athletes
#8
Samuel Sigrist, Thomas Maier, Raphael Faiss
PURPOSE: Track cycling team pursuit (TP) is a highly technical effort involving 4 athletes completing 4 km from a standing start often in less than 240 s. Transitions between athletes leading the team are obviously of utmost importance. The aim of this study is to perform qualitative video analyses of transitions of world-class athletes in team pursuit competitions. METHODS: Videos captured at 100 Hz were recorded for 77 races (including 96 different athletes) in 5 international track cycling competitions (e...
March 14, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28286752/utility-of-mri-for-characterizing-articular-cartilage-pathology-in-dogs-with-medial-coronoid-process-disease
#9
Samuel P Franklin, Emily E Burke, Shannon P Holmes
OBJECTIVE: To determine whether assessment of morphological MRI sequences or delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) would have strong correlations with arthroscopic assessment of cartilage pathology in dogs with naturally occurring medial compartment pathology of the elbow. METHODS: Dogs tentatively diagnosed with medial coronoid disease had evaluation of their affected elbows using radiography, morphological MRI sequences, and dGEMRIC MRI evaluation prior to arthroscopy...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28274618/what-factors-drive-inpatient-satisfaction-after-knee-arthroplasty
#10
Ashwin Peres-da-Silva, Lindsay T Kleeman, Samuel S Wellman, Cynthia L Green, David E Attarian, Michael P Bolognesi, Thorsten M Seyler
BACKGROUND: The Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) survey, developed by the Centers for Medicare & Medicaid Services, is directly tied to hospital reimbursement. The purpose of this study is to analyze survey responses from patients who underwent primary knee arthroplasty in order to identify factors that drive patient dissatisfaction in the inpatient setting. METHODS: HCAHPS responses received from patients undergoing elective total and unicompartmental knee arthroplasty at our institution between January 1, 2013 and January 1, 2016 were obtained and expressed as a percentage of overall satisfaction...
February 1, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28269718/analysis-of-the-sleep-eeg-in-the-complexity-domain
#11
Sara Mariani, Ana F T Borges, Teresa Henriques, Robert J Thomas, Samuel J Leistedt, Paul Linkowski, Jean-Pol Lanquart, Ary L Goldberger, Madalena D Costa
Conventional sleep analysis relies primarily on electroencephalogram (EEG) waveform features assessed in concert with eye movements, respiration and muscle tone. We explore a complementary "complexity domain" approach based on multiscale entropy (MSE) analysis of EEG signals and discuss its relationships to standard sleep analysis and to that based on electrocardiogram (ECG)-derived cardiopulmonary coupling (CPC). We observe a progressive decrease in complexity associated with decreased arousability, as measured by both conventional sleep scoring and CPC analysis...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28264873/genetically-predicted-telomere-length-is-not-associated-with-pancreatic-cancer-risk
#12
Samuel O Antwi, William R Bamlet, Brendan T Broderick, Kari G Chaffee, Ann L Oberg, Aminah Jatoi, Lisa A Boardman, Gloria M Petersen
BACKGROUND: Epidemiologic associations of leukocyte telomere length (LTL) and pancreatic ductal adenocarcinoma (PDAC) have been inconsistent owing, in part, to variation in telomere length (TL) assessment across studies. To overcome this limitation and address concerns of potential reverse causation, we used carriage of telomere-related alleles to genetically predict TL and examined its association with PDAC. METHODS: A case-control study of 1,500 PDAC cases and 1,500 controls, frequency-matched on age and sex was performed...
March 6, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28264721/densitometric-and-local-histogram-based-analysis-of-computed-tomography-images-in-patients-with-idiopathic-pulmonary-fibrosis
#13
Samuel Y Ash, Rola Harmouche, Diego Lassala Lopez Vallejo, Julian A Villalba, Kris Ostridge, River Gunville, Carolyn E Come, Jorge Onieva Onieva, James C Ross, Gary M Hunninghake, Souheil Y El-Chemaly, Tracy J Doyle, Pietro Nardelli, Gonzalo V Sanchez-Ferrero, Hilary J Goldberg, Ivan O Rosas, Raul San Jose Estepar, George R Washko
BACKGROUND: Prior studies of clinical prognostication in idiopathic pulmonary fibrosis (IPF) using computed tomography (CT) have often used subjective analyses or have evaluated quantitative measures in isolation. This study examined associations between both densitometric and local histogram based quantitative CT measurements with pulmonary function test (PFT) parameters and mortality. In addition, this study sought to compare risk prediction scores that incorporate quantitative CT measures with previously described systems...
March 7, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28263939/association-between-physician-teamwork-and-health-system-outcomes-after-coronary-artery-bypass-grafting
#14
John M Hollingsworth, Russell J Funk, Spencer A Garrison, Jason Owen-Smith, Samuel A Kaufman, Francis D Pagani, Brahmajee K Nallamothu
BACKGROUND: Patients undergoing coronary artery bypass grafting (CABG) must often see multiple providers dispersed across many care locations. To test whether teamwork (assessed with the bipartite clustering coefficient) among these physicians is a determinant of surgical outcomes, we examined national Medicare data from patients undergoing CABG. METHODS AND RESULTS: Among Medicare beneficiaries who underwent CABG between 2008 and 2011, we mapped relationships between all physicians who treated them during their surgical episodes, including both surgeons and nonsurgeons...
November 2016: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/28262403/clinical-predictors-for-favorable-outcomes-from-endovascular-recanalization-in-wake-up-stroke
#15
Sang Min Sung, Tae Hong Lee, Han Jin Cho, Gi Yong Cho, Dae Soo Jung, Jae Il Lee, Jun Kyeung Ko, Samuel Yip
BACKGROUND AND PURPOSE: Patients who have acute stroke symptoms present on awakening are ineligible for standard intravenous thrombolysis due to the unclear onset time of symptoms. Some of these wake-up stroke (WUS) patients may benefit from endovascular recanalization. This study aimed to evaluate clinical predictors of outcomes from endovascular recanalization in WUS patients. METHODS: Forty-one WUS patients with internal carotid (ICA) or middle cerebral artery (MCA) occlusion treated with endovascular recanalization were reviewed...
March 2, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28260605/gambling-disorder-dsm-5-criteria-and-symptom-severity
#16
Jon E Grant, Brian L Odlaug, Samuel R Chamberlain
INTRODUCTION: Gambling disorder (GD) is a prevalent psychiatric condition whose severity is typically defined by the number of DSM-5 criteria met out of a maximum of nine. The relationships between the levels of gambling severity, thus defined, and other measures of psychopathology and everyday functioning are clinically important. METHODS: Baseline data were collected in patients with GD, conducted from 2001 to 2016. Participants completed clinical interviews and questionnaires...
February 21, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28249645/adjuvant-therapies-utilization-pattern-and-survival-outcomes-in-high-grade-head-and-neck-soft-tissue-sarcoma-a-population-based-study
#17
Omar Mahmoud, Robert Beck, Evelyne Kalyoussef, Richard Chan Park, Soly Baredes, Sung Kim, Michael A Samuels
PURPOSE: Head and neck soft tissue sarcoma (HNSTS) is a distinct entity within the soft tissue sarcoma group and the evidence supporting treatment options for this disease is poorly defined. Using the National Cancer Database, this study aims to reveal adjuvant therapy utilization patterns and their outcomes. MATERIALS: HNSTS patients constituted 6.5% of all sarcoma patients and the analysis was limited to non-metastatic patients who underwent resection between 2004 and 2012...
March 2017: Oral Oncology
https://www.readbyqxmd.com/read/28249090/performance-of-vascular-exposure-and-fasciotomy-among-surgical-residents-before-and-after-training-compared-with-experts
#18
Colin F Mackenzie, Evan Garofalo, Adam Puche, Hegang Chen, Kristy Pugh, Stacy Shackelford, Samuel Tisherman, Sharon Henry, Mark W Bowyer
Importance: Surgical patient outcomes are related to surgeon skills. Objective: To measure resident surgeon technical and nontechnical skills for trauma core competencies before and after training and up to 18 months later and to compare resident performance with the performance of expert traumatologists. Design, Setting, and Participants: This longitudinal study performed from May 1, 2013, through February 29, 2016, at Maryland State Anatomy Board cadaver laboratories included 40 surgical residents and 10 expert traumatologists...
March 1, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28247032/effect-of-a-patient-tailored-integrative-medicine-program-on-gastro-intestinal-concerns-and-quality-of-life-in-patients-with-breast-and-gynecologic-cancer
#19
Ilanit Shalom-Sharabi, Noah Samuels, Ofer Lavie, Efraim Lev, Lital Keinan-Boker, Elad Schiff, Eran Ben-Arye
CONTEXT AND OBJECTIVES: This study was conducted to assess the impact of a patient-tailored complementary/integrative medicine (CIM) program on gastro-intestinal (GI) symptoms and other concerns in female patients with breast/gynecological cancer undergoing chemotherapy. METHODS: Patients with breast/gynecological cancer reporting GI-related concerns were referred to an integrative physician (IP) consultation. The treatment group included patients agreeing to attend the consultation; controls those who did not...
February 28, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28245585/a-novel-technique-for-fetal-ecg-extraction-using-single-channel-abdominal-recording
#20
Nannan Zhang, Jinyong Zhang, Hui Li, Omisore Olatunji Mumini, Oluwarotimi Williams Samuel, Kamen Ivanov, Lei Wang
Non-invasive fetal electrocardiograms (FECGs) are an alternative method to standard means of fetal monitoring which permit long-term continual monitoring. However, in abdominal recording, the FECG amplitude is weak in the temporal domain and overlaps with the maternal electrocardiogram (MECG) in the spectral domain. Research in the area of non-invasive separations of FECG from abdominal electrocardiograms (AECGs) is in its infancy and several studies are currently focusing on this area. An adaptive noise canceller (ANC) is commonly used for cancelling interference in cases where the reference signal only correlates with an interference signal, and not with a signal of interest...
February 24, 2017: Sensors
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