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https://www.readbyqxmd.com/read/29149151/sacroplasty-a-ten-year-analysis-of-prospective-patients-treated-with-percutaneous-sacroplasty-literature-review-and-technical-considerations
#1
Michael E Frey, Christopher Warner, Samuel M Thomas, Karan Johar, Heathpaul Singh, Maheen S Mohammad, Douglas P Beall
BACKGROUND: The treatment of sacral fractures has evolved since its first description in 1982. Several techniques for sacral augmentation have been developed since 2001, and the rate of improvement is rapid with over 50% reduction in pain achieved prior to post-procedure discharge of the patient. Pain reduction occurs primarily within the first 3 months and is sustained at 12 months; however, the long-term outcomes have not previously been studied. OBJECTIVES: We aim to evaluate the long-term efficacy of sacroplasty versus non-surgical management (NSM) in treating sacral insufficiency fractures (SIFs), including the effect on pain relief, opioid and other analgesic use, patient satisfaction, and complication rates...
November 2017: Pain Physician
https://www.readbyqxmd.com/read/29144580/higher-retransplantation-rate-following-extended-right-split-liver-transplantation-an-analysis-from-the-eurotransplant-liver-follow-up-registry
#2
J Andrassy, S Wolf, M Lauseker, M Angele, M D van Rosmalen, U Samuel, X Rogiers, J Werner, M Guba
Split liver transplantation (SLT) has been perceived as an important strategy to increase the supply of liver grafts by creating 2 transplants from 1 allograft. The Eurotransplant allocation system (ELAS) envisages that the ERLs after splitting (usually in the pediatric center) are almost exclusively shipped to a second center. Whether the ELAS policy impacts the graft and patient survival of ERLT in comparison to WLT recipients remains unclear. Data on all LTs performed between 2007 and 2013 were retrieved from the ET Liver follow-up Registry (n=5351)...
November 16, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/29142620/elevated-blood-urea-nitrogen-creatinine-ratio-is-associated-with-venous-thromboembolism-in-patients-with-acute-ischemic-stroke
#3
Hoon Kim, Kiwon Lee, Huimahn A Choi, Sophie Samuel, Jung Hyn Park, Kwang Wook Jo
Objective: Although venous thromboembolism (VTE) is frequently related to dehydration, the impact of dehydration on VTE in acute ischemic stroke (AIS) is not clear. This study investigated whether dehydration, as measured by blood urea nitrogen (BUN)/creatinine (Cr) ratio, influences the occurrence of VTE in patients with AIS. Methods: This is a retrospective study of patients with AIS between January 2012 and December 2013. Patients with newly diagnosed AIS who experienced prolonged hospitalization for at least 4 weeks were included in this study...
November 2017: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/29141677/factors-associated-with-oral-glucocorticoid-use-in-patients-with-rheumatoid-arthritis-a-drug-use-study-from-a-prospective-national-biologics-registry
#4
Rachel J Black, Susan Lester, Rachelle Buchbinder, Claire Barrett, Marissa Lassere, Lyn March, Samuel Whittle, Catherine L Hill
BACKGROUND: Glucocorticoids (GCs) are used in ~ 60% of patients with rheumatoid arthritis (RA). Although disease-modifying, they also have significant adverse effects. Understanding factors associated with GC use may help minimise exposure. The aims of the present study were to describe oral GC use in RA; determine any change in use over time; and determine factors associated with oral GC use, commencement or cessation. METHODS: Adult patients with RA were identified in the Australian Rheumatology Association Database (ARAD), a national Australian registry that collects long-term outcome data from patients with inflammatory arthritis...
November 15, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29141651/the-dose-of-behavioral-interventions-to-prevent-and-treat-childhood-obesity-a-systematic-review-and-meta-regression
#5
REVIEW
William J Heerman, Meghan M JaKa, Jerica M Berge, Erika S Trapl, Evan C Sommer, Lauren R Samuels, Natalie Jackson, Jacob L Haapala, Alicia S Kunin-Batson, Barbara A Olson-Bullis, Heather K Hardin, Nancy E Sherwood, Shari L Barkin
BACKGROUND: A better understanding of the optimal "dose" of behavioral interventions to affect change in weight-related outcomes is a critical topic for childhood obesity intervention research. The objective of this review was to quantify the relationship between dose and outcome in behavioral trials targeting childhood obesity to guide future intervention development. METHODS: A systematic review and meta-regression included randomized controlled trials published between 1990 and June 2017 that tested a behavioral intervention for obesity among children 2-18 years old...
November 15, 2017: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/29134621/replication-of-mini-sentinel-study-assessing-mirabegron-and-cardiovascular-risk-in-non-mini-sentinel-databases
#6
Jason C Simeone, Beth L Nordstrom, Kwame Appenteng, Samuel Huse, Milbhor D'Silva
BACKGROUND: In 2014, the US Food and Drug Administration (FDA) initiated a prospective routine surveillance using the Mini-Sentinel (M-S) program to assess potential signals of acute myocardial infarction (AMI) and stroke with use of mirabegron, indicated for the treatment of overactive bladder (OAB), compared with oxybutynin. PURPOSE: To replicate the FDA M-S analysis of mirabegron using datasets that did not contribute to the M-S program. METHODS: IMS PharMetrics Plus and Truven MarketScan claims data from 2012-2015 were converted to the M-S Common Data Model...
November 13, 2017: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/29131690/investigating-ioflupane-i-123-injection-and-single-photon-emission-tomography-as-an-imaging-biomarker-for-long-term-sequelae-following-mild-traumatic-brain-injury
#7
Nicole Reams, Julie Anderson, Reid Perlman, Wei Li, Shaun Walters, Samuel Tideman, Chi Wang, Kelly Simon, Roberta Frigerio, Demetrius M Maraganore
OBJECTIVE: To determine whether there were differences in clinical outcomes for ioflupane I(123) injection (DaTscan) and single photon emission tomography consistent with early Parkinson's disease (PD) among individuals with a history of mild traumatic brain injury (mTBI). METHODS: We performed a case-control study among patients presenting to the Emergency Room (ER) during 2006-2013 with mTBI (cases, n = 34) or without mTBI (controls, n = 33). We performed clinical and imaging measurements in cases and controls at least 1-year post-presentation to the ER (average three years four months)...
November 13, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29130649/sino-nasal-outcome-test-22-quality-of-life-patterns-in-patients-presenting-with-nasal-septal-perforation
#8
Samuel C Leong, Christopher J Webb
OBJECTIVES: To assess the impact of nasal septal perforation on quality of life. DESIGN: Retrospective cohort study. SETTING: Rhinology clinics from two hospitals in Liverpool, United Kingdom. PARTICIPANTS: Patients diagnosed with nasal septal perforation (NSP). MAIN OUTCOME MEASURES: Patients (n=26) diagnosed with NSP completed the Sino-Nasal Outcome Test-22 (SNOT-22). The collated data was compared with SNOT-22 scores from a cohort of healthy volunteers (n=34) and a cohort of patients (n=30) diagnosed with chronic rhinosinusitis (CRS)...
November 11, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29126040/5-year-results-of-the-1-5cm-incision-achilles-tendon-repair
#9
Samuel K K Ling, Amanda Slocum, T H Lui
BACKGROUND: To study a hypothesis that the cost-effective 1.5cm medial incision Achilles tendon repair technique will provide good functional outcomes which are maintained for over 5 years. METHOD: Prospective study of 12 consecutive cases with a minimal 5-year follow-up were recruited from April 2008 to November 2010. Cases whom were mentally incompetent or those which required concomitant procedures were excluded. Outcomes measures included the numeric pain rating scale, motor power strength, range of motion, functional scoring using the AOFAS hindfoot score and patient's self-assessment using the Foot and Ankle Outcome Score (FAOS)...
June 16, 2017: Foot
https://www.readbyqxmd.com/read/29122932/diagnostic-performance-of-an-acoustic-based-system-for-coronary-artery-disease-risk-stratification
#10
Simon Winther, Louise Nissen, Samuel Emil Schmidt, Jelmer Sybren Westra, Laust Dupont Rasmussen, Lars Lyhne Knudsen, Lene Helleskov Madsen, Jane Kirk Johansen, Bjarke Skogstad Larsen, Johannes Jan Struijk, Lars Frost, Niels Ramsing Holm, Evald Høj Christiansen, Hans Erik Botker, Morten Bøttcher
OBJECTIVE: Diagnosing coronary artery disease (CAD) continues to require substantial healthcare resources. Acoustic analysis of transcutaneous heart sounds of cardiac movement and intracoronary turbulence due to obstructive coronary disease could potentially change this. The aim of this study was thus to test the diagnostic accuracy of a new portable acoustic device for detection of CAD. METHODS: We included 1675 patients consecutively with low to intermediate likelihood of CAD who had been referred for cardiac CT angiography...
November 9, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29122893/prospective-postmarketing-surveillance-of-acute-myocardial-infarction-in-new-users-of-saxagliptin-a-population-based-study
#11
Sengwee Toh, Marsha E Reichman, David J Graham, Christian Hampp, Rongmei Zhang, Melissa G Butler, Aarthi Iyer, Malcolm Rucker, Madelyn Pimentel, Jack Hamilton, Samuel Lendle, Bruce H Fireman
OBJECTIVE: The cardiovascular safety of saxagliptin, a dipeptidyl-peptidase 4 inhibitor, compared with other antihyperglycemic treatments is not well understood. We prospectively examined the association between saxagliptin use and acute myocardial infarction (AMI). RESEARCH DESIGN AND METHODS: We identified patients aged ≥18 years, starting from the approval date of saxagliptin in 2009 and continuing through August 2014, using data from 18 Mini-Sentinel data partners...
November 9, 2017: Diabetes Care
https://www.readbyqxmd.com/read/29122246/nurses-knowledge-clinical-practice-and-attitude-towards-unconventional-medicine-implications-for-intercultural-healthcare
#12
Razak Mohammed Gyasi, Kabila Abass, Samuel Adu-Gyamfi, Burnett Tetteh Accam
OBJECTIVE: The aim of this hospital-based, cross-sectional study was to examine nurses' knowledge, personal and professional practices and attitude towards complementary and alternative medical therapies in urban Ghana. METHOD: Using convenience sampling technique, cross-sectional data were collected from 210 registered and practicing nurses with self-administered questionnaire based on the Complementary and Alternative Medicine (CAM) Health Belief Questionnaire (CHBQ)...
November 2017: Complementary Therapies in Clinical Practice
https://www.readbyqxmd.com/read/29116326/performance-comparison-of-single-radius-versus-multiple-curve-femoral-component-in-total-knee-arthroplasty-a-prospective-randomized-study-using-the-lower-quarter-y-balance-test
#13
Samuel S Wellman, Mitchell R Klement, Robin M Queen
Midflexion stability after total knee arthroplasty (TKA) is dependent, in part, on implant design. Midflexion performance of a single-radius (SR) design and a multi-radius, or J-curve (JC), design were compared using the Lower Quarter Y-Balance Test (YBT-LQ). Patient-reported outcomes and measures of physical performance were also compared. The authors hypothesized that the SR design would provide superior midflexion stability and, therefore, a greater reach distance in the YBT-LQ when compared with the JC design...
November 1, 2017: Orthopedics
https://www.readbyqxmd.com/read/29113986/muscadine-grape-skin-extract-in-men-with-biochemically-recurrent-prostate-cancer-a-randomized-multicenter-placebo-controlled-clinical-trial
#14
Channing J Paller, Xian C Zhou, Elisabeth I Heath, Mary-Ellen Taplin, Tina Mayer, Mark N Stein, Glenn J Bubley, Roberto Pili, Tamaro Hudson, Radhika Kakarla, Muneer M Abbas, Nicole M Anders, Donna Dowling, Serina King, Ashley B Bruns, William D Wagner, Charles G Drake, Emmanuel S Antonarakis, Mario A Eisenberger, Samuel R Denmeade, Michelle A Rudek, Gary L Rosner, Michael A Carducci
PURPOSE: MPX, a commercial preparation of pulverized muscadine grape skin, was evaluated as a therapeutic option for men with biochemically recurrent (BCR) prostate cancer (PCa) wishing to defer androgen deprivation therapy. EXPERIMENTAL DESIGN: This was a 12-month, multi-center, placebo-controlled, two-dose, double-blinded trial of MPX in 125 men with BCR PCa, powered to detect a prostate specific antigen doubling time (PSADT) difference of 6 months (low-dose) and 12 months (high-dose) relative to placebo...
November 7, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29110948/bioprosthetic-aortic-valve-replacement-revisiting-prosthesis-choice-in-patients-younger-than-50%C3%A2-years-old
#15
Samuel R Schnittman, David H Adams, Shinobu Itagaki, Nana Toyoda, Natalia N Egorova, Joanna Chikwe
OBJECTIVE: Aortic prosthesis choice is controversial in young adults because robust comparative outcome data are lacking. We therefore compared mortality and morbidity in young adults after bioprosthetic versus mechanical aortic valve replacement. METHODS: This was a retrospective analysis of 5111 patients aged 18 to 50 years undergoing primary aortic valve replacement in California and New York State from 1997 to 2006. Median follow-up time was 11.8 years (maximum 18...
September 13, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29108950/amoxicillin-for-acute-lower-respiratory-tract-infection-in-primary-care-subgroup-analysis-by-bacterial-and-viral-etiology
#16
Robin Bruyndonckx, Beth Stuart, Paul Little, Niel Hens, Margareta Ieven, Christopher C Butler, Theo Verheij, Herman Goossens, Samuel Coenen
OBJECTIVE: We aimed to assess the effects of amoxicillin treatment in adult patients presenting to primary care with a lower respiratory tract infection (LRTI) who are infected with a potential bacterial, viral, or mixed bacterial/viral infection. METHODS: The multicenter randomized controlled trial focused on adults with LRTI not suspected for pneumonia. Patients were randomized to receive either antibiotic (amoxicillin 1g) or placebo three times daily for seven consecutive days using computer-generated random numbers (follow-up 28 days)...
November 3, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29107679/efficacy-and-safety-of-selective-internal-radiotherapy-with-yttrium-90-resin-microspheres-compared-with-sorafenib-in-locally-advanced-and-inoperable-hepatocellular-carcinoma-sarah-an-open-label-randomised-controlled-phase-3-trial
#17
Valérie Vilgrain, Helena Pereira, Eric Assenat, Boris Guiu, Alina Diana Ilonca, Georges-Philippe Pageaux, Annie Sibert, Mohamed Bouattour, Rachida Lebtahi, Wassim Allaham, Hélène Barraud, Valérie Laurent, Elodie Mathias, Jean-Pierre Bronowicki, Jean-Pierre Tasu, Rémy Perdrisot, Christine Silvain, René Gerolami, Olivier Mundler, Jean-Francois Seitz, Vincent Vidal, Christophe Aubé, Frédéric Oberti, Olivier Couturier, Isabelle Brenot-Rossi, Jean-Luc Raoul, Anthony Sarran, Charlotte Costentin, Emmanuel Itti, Alain Luciani, René Adam, Maïté Lewin, Didier Samuel, Maxime Ronot, Aurelia Dinut, Laurent Castera, Gilles Chatellier
BACKGROUND: Sorafenib is the recommended treatment for patients with advanced hepatocellular carcinoma. We aimed to compare the efficacy and safety of sorafenib to that of selective internal radiotherapy (SIRT) with yttrium-90 ((90)Y) resin microspheres in patients with hepatocellular carcinoma. METHODS: SARAH was a multicentre, open-label, randomised, controlled, investigator-initiated, phase 3 trial done at 25 centres specialising in liver diseases in France. Patients were eligible if they were aged at least 18 years with a life expectancy greater than 3 months, had an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1, Child-Pugh liver function class A or B score of 7 or lower, and locally advanced hepatocellular carcinoma (Barcelona Clinic Liver Cancer [BCLC] stage C), or new hepatocellular carcinoma not eligible for surgical resection, liver transplantation, or thermal ablation after a previously cured hepatocellular carcinoma (cured by surgery or thermoablative therapy), or hepatocellular carcinoma with two unsuccessful rounds of transarterial chemoembolisation...
October 26, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/29107358/patient-reported-outcomes-in-adults-with-congenital-heart-disease-inter-country-variation-standard-of-living-and-healthcare-system-factors
#18
Philip Moons, Adrienne H Kovacs, Koen Luyckx, Corina Thomet, Werner Budts, Junko Enomoto, Maayke A Sluman, Hsiao-Ling Yang, Jamie L Jackson, Paul Khairy, Stephen C Cook, Raghavan Subramanyan, Luis Alday, Katrine Eriksen, Mikael Dellborg, Malin Berghammer, Bengt Johansson, Andrew S Mackie, Samuel Menahem, Maryanne Caruana, Gruschen Veldtman, Alexandra Soufi, Susan M Fernandes, Kamila White, Edward Callus, Shelby Kutty, Liesbet Van Bulck, Silke Apers
AIMS: Geographical differences in patient-reported outcomes (PROs) of adults with congenital heart disease (ConHD) have been observed, but are poorly understood. We aimed to: (1) investigate inter-country variation in PROs in adults with ConHD; (2) identify patient-related predictors of PROs; and (3) explore standard of living and healthcare system characteristics as predictors of PROs. METHODS AND RESULTS: Assessment of Patterns of Patient-Reported Outcomes in Adults with Congenital Heart disease - International Study (APPROACH-IS) was a cross-sectional, observational study, in which 4028 patients from 15 countries in 5 continents were enrolled...
October 21, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29107271/whom-to-treat-postdiagnostic-risk-assessment-with-gleason-score-risk-models-and-genomic-classifier
#19
REVIEW
Annika Herlemann, Samuel L Washington, Renu S Eapen, Matthew R Cooperberg
Management of prostate cancer presents unique challenges because of the disease's variable natural history. Accurate risk stratification at the time of diagnosis in clinically localized disease is crucial in providing optimal counseling about management options. To accurately distinguish pathologically indolent tumors from aggressive disease, risk groups are no longer sufficient. Rather, multivariable prognostic models reflecting the complete information known at time of diagnosis offer improved accuracy and interpretability...
November 2017: Urologic Clinics of North America
https://www.readbyqxmd.com/read/29105238/comparing-state-wide-and-single-center-data-to-predict-high-frequency-emergency-department-utilization-among-patients-with-asthma-exacerbation
#20
Margaret E Samuels-Kalow, Mohammad K Faridi, Janice A Espinola, Jean E Klig, Carlos A Camargo
BACKGROUND: Previous studies examining high-frequency ED utilization have primarily used single-center data, potentially leading to ascertainment bias if patients visit multiple centers. The goals of this study were (1) to create a predictive model to prospectively identify patients at risk of high-frequency ED utilization for asthma, and (2) to examine how that model differed using state-wide versus single-center data. METHODS: To track ED visits within a state, we analyzed 2011-2013 data from the New York State Healthcare Cost and Utilization Project (HCUP) State Emergency Department Databases (SEDD)...
November 4, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
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