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https://www.readbyqxmd.com/read/29352772/neurotransmitters-and-receptors-changes-in-medial-nucleus-of-the-trapezoid-body-mntb-of-early-developmental-rats-with-single-side-deafness
#1
Jinsheng Dai, Jinfeng Liu, Mo Zhou, Wenjiao Wang, Zhi-Qing David Xu, Ningyu Wang
BACKGROUND Congenital single-side deafness (SSD) affects sound localization even after cochlear implantation (CI) in some conditions. The medial nucleus of the trapezoid body (MNTB) plays an important role in binaural benefit and sound localization, but little is known about intrinsic molecular changes in MNTB with SSD. We aimed to observe changes in MNTB in early-developmental SSD rats, including the key neurotransmitters (GABA, Gly, Glu) and major receptors (GABAa-R/GABAb-R for GABA, Gly-R for Gly, and AMPA/NMDA for Glu)...
January 20, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29352722/daily-intake-of-mucuna-pruriens-in-advanced-parkinson-s-disease-a-16-week-noninferiority-randomized-crossover-pilot-study
#2
Roberto Cilia, Janeth Laguna, Erica Cassani, Emanuele Cereda, Benedetta Raspini, Michela Barichella, Gianni Pezzoli
BACKGROUND: Thousands of individuals with Parkinson's disease (PD) in low-income countries have limited access to marketed levodopa preparations. Mucuna pruriens (MP), a levodopa-containing leguminous plant growing in tropical areas, may be a sustainable alternative therapy for indigent patients. Single-dose intake of MP proved noninferior to marketed levodopa preparations. METHODS: Fourteen PD patients with motor fluctuations and dyskinesias received MP powder (obtained from roasted seeds) and marketed levodopa/carbidopa (LD/CD) in a randomized order and crossover design over a 16-week period...
January 11, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29352713/clinical-variables-associated-with-overall-survival-in-metastatic-castration-resistant-prostate-cancer-patients-treated-with-sipuleucel-t-immunotherapy
#3
Xiao X Wei, Jaselle Perry, Emily Chang, Li Zhang, Robert A Hiatt, Charles J Ryan, Eric J Small, Lawrence Fong
BACKGROUND: Sipuleucel-T is an autologous cell-based cancer immunotherapy for men with asymptomatic or minimally symptomatic metastatic castration-resistant prostate cancer (mCRPC). Its approval by the Food and Drug Administration was based on demonstration of an overall survival (OS) benefit in randomized placebo-controlled phase III trials. However, treatment was associated with a prostate-specific antigen (PSA) decline in only a small minority of patients. Understanding the clinical factors that are associated with OS could help guide treatment decisions, including patient selection and the timing of sipuleucel-T relative to other therapies...
December 27, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29352695/truly-anatomic-coracoclavicular-ligament-reconstruction-with-2-endobutton-devices-for-acute-rockwood-type-v-acromioclavicular-joint-dislocations
#4
Cheng Xue, Li-Jun Song, Hao Zhang, Guo-Long Tang, Xiang Li, Jia-Hu Fang
BACKGROUND: Truly anatomic coracoclavicular ligament reconstruction (TACCR) according to the original insertions is a creative new method for the treatment of severe acromioclavicular separation. This research analyzed the clinical and radiologic results of TACCR in 25 patients with at least 2-year follow-up. METHODS: The study enrolled 25 patients with Rockwood type V acromioclavicular joint dislocations who underwent TACCR using 2 Endobutton (Smith & Nephew Inc...
January 15, 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29352676/cardiorespiratory-dynamics-of-rescuers-during-cardiopulmonary-resuscitation-in-a-hypoxic-environment
#5
Tomonobu Sato, Tomonori Takazawa, Masahiro Inoue, Yasunori Tada, Takashi Suto, Masaru Tobe, Shigeru Saito
OBJECTIVE: We had previously experienced a case involving prolonged cardiopulmonary resuscitation (CPR) on Mt. Fuji (3776 m), demanding strenuous work by the rescuers. The objective of this study was to compare the effect of compression-only and conventional CPR on oxygen saturation of rescuers in a hypoxemic environment. METHODS: Changes in percutaneous arterial oxygen saturation (SpO2) and heart rate during CPR action were measured in a hypobaric chamber with barometric pressure adjusted to be equivalent to 3700 m above sea level (630-640 hPa)...
January 8, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29352668/the-effect-of-single-and-repeated-prefrontal-intermittent-theta-burst-stimulation-on-cortical-reactivity-and-working-memory
#6
Sung Wook Chung, Nigel C Rogasch, Kate E Hoy, Paul B Fitzgerald
BACKGROUND: With an increasing interest in the use of theta burst stimulation (TBS) as a cognitive enhancer and a potential therapeutic tool for psychiatric disorders, there is a need to identify optimal parameters of TBS in the prefrontal cortex. OBJECTIVE/HYPOTHESIS: This study examined the effect of two blocks of prefrontal intermittent TBS (iTBS) on cortical reactivity and working memory performance, compared to one block of iTBS and sham stimulation. We hypothesized that greater cortical effects would be obtained with two blocks of iTBS...
January 8, 2018: Brain Stimulation
https://www.readbyqxmd.com/read/29352662/distinct-progression-patterns-of-brain-disease-in-infantile-and-juvenile-gangliosidoses-volumetric-quantitative-mri-study
#7
Igor Nestrasil, Alia Ahmed, Josephine M Utz, Kyle Rudser, Chester B Whitley, Jeanine R Jarnes-Utz
BACKGROUND: GM1-gangliosidosis and GM2-gangliosidosis (Tay-Sachs disease and Sandhoff disease) are unrelenting heritable neurodegenerative conditions of lysosomal ganglioside accumulation. Although progressive brain atrophy is characteristic, longitudinal quantification of specific brain structures has not been systematically studied. OBJECTIVES: The goal of this longitudinal study has been to quantify and track brain MRI volume changes, including specific structure volume changes, at different times in disease progression of childhood gangliosidoses, and to explore quantitative brain MRI volumetry (qMRI) as a non-invasive marker of disease progression for future treatment trials...
December 20, 2017: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/29352654/resistance-training-during-a-12-week-protein-supplemented-vlcd-treatment-enhances-weight-loss-outcomes-in-obese-patients
#8
Edward Jo, Phillip R Worts, Marcus L Elam, Ann Frost Brown, Andy V Khamoui, Do-Houn Kim, Ming-Chia Yeh, Michael J Ormsbee, Carla M Prado, Angelina Cain, Katie Snyder, Jeong-Su Kim
BACKGROUND: This investigation evaluated the efficacy by which resistance training enhances body composition, metabolic, and functional outcomes for obese patients undergoing a 12-week medically supervised hypocaloric treatment. METHODS: This was a single-blind, randomized, parallel-group prospective trial. Morbidly obese patients were prescribed a 12-week proprietary very low calorie diet (VLCD) treatment (Optifast®) with supplemental protein (1120 kcals/day) and were placed in one of two groups for 14 weeks: 1) Standard Treatment Control (CON) (n = 5) or 2) Resistance Training (RT) (n = 6)...
December 23, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29352649/optimal-use-of-peri-operative-human-chorionic-gonadotrophin-concentrations-to-identify-persistent-ectopic-pregnancy-after-laparoscopic-salpingostomy-a-retrospective-cohort-study
#9
Abraham N Morse, Wenyue Si, Shuang Qin, Huiying Liang
The aim of this study was to improve clinical decision-making for the identification of persistent ectopic pregnancy after linear salpingostomy. The study identified 854 laparoscopic salpingostomies performed between 2011 and 2016; 794 had a human chorionic gonadotrophin (HCG) <10 mIU/ml documented in the electronic medical record within 1 month after surgery ('successes'). Sixty (7%) received either methotrexate or repeat surgery for persistent ectopic pregnancy ('failures'). Five hundred and seventeen, including 46 'failures', had two or more immediate post-operative HCG measurements available...
December 28, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29352643/assessment-of-a-source-position-checking-tool-for-the-quality-assurance-of-transfer-tubes-used-in-hdr-192ir-brachytherapy-treatments
#10
O A Awunor
PURPOSE: The determination of source positions before treatment is an essential part of the quality assurance (QA) associated with high dose rate brachytherapy treatments. The purpose of this study was to design and commission a tool to allow the quantification of source positions across multiple transfer tube types. METHODS AND MATERIALS: A bespoke flexi-adapter jig, three transfer tube adapters, and a film piercing pointer were designed and built for source position QA across three transfer tube types-the standard, 6 French, and gynae transfer tubes...
January 15, 2018: Brachytherapy
https://www.readbyqxmd.com/read/29352640/recent-advancements-in-bioremediation-of-dye-current-status-and-challenges
#11
REVIEW
Kumar Vikrant, Balendu Shekhar Giri, Nadeem Raza, Kangkan Roy, Ki-Hyun Kim, Birendra Nath Rai, Ram Sharan Singh
The rampant industrialization and unchecked growth of modern textile production facilities coupled with the lack of proper treatment facilities have proliferated the discharge of effluents enriched with toxic, baleful, and carcinogenic pollutants including dyes, heavy metals, volatile organic compounds, odorants, and other hazardous materials. Therefore, the development of cost-effective and efficient control measures against such pollution is imperative to safeguard ecosystems and natural resources. In this regard, recent advances in biotechnology and microbiology have propelled bioremediation as a prospective alternative to traditional treatment methods...
January 8, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29352626/differences-between-sexes-in-the-standard-and-advanced-dimensioning-of-lateral-meniscal-allografts
#12
Patrycja Mickiewicz, Michał Walczak, Michał Łaszczyca, Damian Kusz, Zygmunt Wróbel
BACKGROUND: There are many different methods of meniscal allograft measurements, which depend on individual tissue bank procedures. Due to the lack of a standardised method of dimensioning, measurement results may vary between individual cases. Consequently, allograft may be mismatched to the patient's knee anatomy. The purpose of this study was to measure four meniscal dimensions - two standard and two specific - and then compare them between sexes. METHODS: Fourteen cadaveric lateral menisci (seven male and seven female) were scanned using a microtomography scanner...
January 15, 2018: Knee
https://www.readbyqxmd.com/read/29352619/quantitative-evaluation-of-enzyme-induced-porcine-articular-cartilage-degeneration-based-on-observation-of-entire-cartilage-layer-using-ultrasound
#13
Jingchen Zhang, Liying Xiao, Lingying Tong, Chao Wan, Zhixiu Hao
Enzyme-induced articular cartilage degeneration resembling osteoarthritis was evaluated using a newly defined acoustic parameter, the "averaged magnitude ratio" (AMR), which has been suggested as an indicator of articular cartilage degeneration. In vitro experiments were conducted on porcine cartilage samples digested with trypsin for 2 h (n = 10) and 4 h (n = 13) and healthy control samples (n = 13). AMR was determined with 15- and 25-MHz ultrasound, and the integrated reflection coefficient (IRC) and apparent integrated backscattering coefficient (AIB) were also calculated for comparison...
January 15, 2018: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29352599/-detection-of-chlamydia-abortus-in-bovine-reproductive-losses-in-the-province-of-la-pampa-argentina
#14
María Del C Rojas, Marcelo Fort, Simone Bettermann, Carolina Entrocassi, Sixto R Costamagna, Konrad Sachse, Marcelo Rodríguez Fermepin
Reproductive losses linked to an infectious etiology in bovine cattle are a major economic concern worldwide. In Argentina, more than 50% of abortion cases have unknown causes. Species belonging to Chlamydiaceae family are frequent etiologic agents of abortion around the world; however, there is yet no information on their prevalence in Argentina. The objective of this work was to identify Chlamydia spp., and particularly C. abortus in reproductive losses from bovine cattle in La Pampa, Argentina. Real time PCR targeting Chlamydiaceae-specific DNA fragments was performed on 251 samples obtained from bovine abortions and stillborns, and ArrayTube was used for species identification on positive samples...
January 16, 2018: Revista Argentina de Microbiología
https://www.readbyqxmd.com/read/29352592/development-and-validation-of-an-icd-10-based-disability-predictive-index-for-patients-admitted-to-hospitals-with-trauma
#15
Tomoki Wada, Hideo Yasunaga, Hayato Yamana, Hiroki Matsui, Kiyohide Fushimi, Naoto Morimura
BACKGROUND: There was no established disability predictive measurement for patients with trauma that could be used in administrative claims databases. The aim of the present study was to develop and validate a diagnosis-based disability predictive index for severe physical disability at discharge using the International Classification of Diseases, 10th revision (ICD-10) coding. METHODS: This retrospective observational study used the Diagnosis Procedure Combination database in Japan...
December 28, 2017: Injury
https://www.readbyqxmd.com/read/29352586/the-impact-of-enhanced-recovery-after-surgery-eras-protocol-compliance-on-morbidity-from-resection-for-primary-lung-cancer
#16
Luke J Rogers, David Bleetman, David E Messenger, Natasha A Joshi, Lesley Wood, Neil J Rasburn, Timothy J P Batchelor
OBJECTIVE: The adoption of Enhanced Recovery After Surgery programs in thoracic surgery is relatively recent with limited outcome data. This study aimed to determine the impact of an Enhanced Recovery After Surgery pathway on morbidity and length of stay in patients undergoing lung resection for primary lung cancer. METHODS: This prospective cohort study collected data on consecutive patients undergoing lung resection for primary lung cancer between April 2012 and June 2014 at a regional referral center in the United Kingdom...
December 19, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29352503/in-vivo-effects-of-%C3%AE-opioid-receptor-agonist-%C3%AE-opioid-receptor-antagonist-peptidomimetics-following-acute-and-repeated-administration
#17
Jessica P Anand, Kelsey E Kochan, Anthony F Nastase, Deanna Montgomery, Nicholas W Griggs, John R Traynor, Henry I Mosberg, Emily M Jutkiewicz
BACKGROUND AND PURPOSE: Mu opioid receptor (μ-receptor) agonists are used for pain management, but produce adverse effects including tolerance, dependence, and euphoria. The co-administration of a μ-receptor agonist with a delta opioid receptor (δ-receptor) antagonist has been shown to produce antinociception with reduced development of some side effects. We characterized the effects of three μ-receptor agonist/δ-receptor antagonist peptidomimetics in vivo after acute and repeated administration to determine if this profile provides a viable alternative to traditional opioid analgesics...
January 19, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29352500/characterization-of-skin-blister-fluids-from-children-with-epstein-barr-virus-associated-lymphoproliferative-disease
#18
Taizo Wada, Tomoko Toma, Hanae Miyazawa, Eiko Koizumi, Tetsujiro Shirahashi, Yusuke Matsuda, Akihiro Yachie
Epstein-Barr virus (EBV)-associated T- or natural killer (NK)-cell lymphoproliferative disease (LPD) is a heterogeneous group of disorders characterized by chronic proliferation of EBV-infected lymphocytes. Patients may present with severe skin manifestations, including hypersensitivity to mosquito bites (HMB) and hydroa vacciniforme (HV)-like eruption, which are characterized by blister formation and necrotic ulceration. Skin biopsy specimens show inflammatory reactions comprising EBV-infected lymphocytes...
January 20, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/29352498/autofocusing-based-phase-correction
#19
Alexander Loktyushin, Philipp Ehses, Bernhard Schölkopf, Klaus Scheffler
PURPOSE: Phase artifacts due to B0 inhomogeneity can severely degrade the quality of MR images. The artifacts are particularly prominent in long-TE scans and usually appear as ghosting and blur. We propose a retrospective phase correction method based on autofocusing. The proposed method uses raw data acquired with standard imaging sequences, and does not rely on navigators or external measures of field inhomogeneity. METHODS: We formulate and solve the optimization problem, where we seek the latent phase offsets that are associated with an optimal value of the image quality measure that is evaluated in the spatial domain...
January 19, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29352479/contrasting-effects-of-specialist-and-generalist-herbivores-on-resistance-evolution-in-invasive-plants
#20
Zhijie Zhang, Xiaoyun Pan, Dana Blumenthal, Mark van Kleunen, Mu Liu, Bo Li
Invasive alien plants are likely to be released from specialist herbivores and at the same time encounter biotic resistance from resident generalist herbivores in their new ranges. The Shifting Defense Hypothesis predicts that this will result in evolution of decreased defense against specialist herbivores and increased defense against generalist herbivores. To test this, we performed a comprehensive meta-analysis of 61 common garden studies that provide data on resistance and/or tolerance for both introduced and native populations of 32 invasive plant species...
January 20, 2018: Ecology
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