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Cardiovascular medicine

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https://www.readbyqxmd.com/read/28229420/noninvasive-assessment-of-cell-fate-and-biology-in-transplanted-mesenchymal-stem-cells
#1
Federico Franchi, Martin Rodriguez-Porcel
Recently, molecular imaging has become a conditio sine qua non for cell-based regenerative medicine. Developments in molecular imaging techniques, such as reporter gene technology, have increasingly enabled the noninvasive assessment of the fate and biology of cells after cardiovascular applications. In this context, bioluminescence imaging is the most commonly used imaging modality in small animal models of preclinical studies. Here, we present a detailed protocol of a reporter gene imaging approach for monitoring the viability and biology of Mesenchymal Stem Cells transplanted in a mouse model of myocardial ischemia reperfusion injury...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28229407/assessment-of-energy-metabolic-changes-in-adipose-tissue-derived-stem-cells
#2
Ghazaleh Hajmousa, Martin C Harmsen
Adipose tissue-derived stem cells (ADSC) are promising candidates for therapeutic applications in cardiovascular regenerative medicine. By definition, the phenotype ADSCs, e.g., the ubiquitous secretion of growth factors, cytokines, and extracellular matrix components is not met in vivo, which renders ADSC a culture "artefact." The medium constituents therefore impact the efficacy of ADSC. Little attention has been paid to the energy source in medium, i.e., glucose, which feeds the cell's power plants: mitochondria...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28227449/comparison-of-methods-for-the-evaluation-of-nibp-from-pulse-transit-time
#3
L Peter, N Noury, M Cerny, I Nykl, L Peter, N Noury, M Cerny, I Nykl, L Peter, I Nykl, N Noury, M Cerny
Non-invasive blood pressure measurement (NIBP) is one of the most discussed topic in cardiovascular medicine. Currently continuous measurement of blood pressure is possible by invasive methods, which makes the measurement impractical for Doctors and uncomfortable for the patients. It is possible to use special devices to measure blood pressure noninvasively continuously but there are still some problems with long time monitoring and comfort for patient. Physiologically there is connection between electrical and mechanical heart functions, propagation of pulse wave and blood pressure value...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28223782/factors-influencing-medication-knowledge-and-beliefs-on-warfarin-adherence-among-patients-with-atrial-fibrillation-in-china
#4
Shujuan Zhao, Hongwei Zhao, Xianpei Wang, Chuanyu Gao, Yuhua Qin, Haixia Cai, Boya Chen, Jingjing Cao
OBJECTIVES: Warfarin is often used for ischemic stroke prevention in patients with atrial fibrillation (AF), but the factors affecting patient adherence to warfarin therapy have not been fully understood. METHODS: A cross-sectional survey was conducted in AF patients undergoing warfarin therapy at least 6 months prior to the study. The clinical data collected using questionnaires by phone interviews included the following: 1) self-reported adherence measured by the Morisky Medication Adherence Scale-8(©); 2) beliefs about medicines surveyed by Beliefs about Medicines Questionnaire (BMQ); and 3) drug knowledge as measured by the Warfarin Related Knowledge Test (WRKT)...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28223221/the-atheroma-plaque-secretome-stimulates-the-mobilization-of-endothelial-progenitor-cells-ex-vivo
#5
Francisco M Vega, Violette Gautier, Cecilia M Fernandez-Ponce, Mª Jesús Extremera, A F Maarten Altelaar, Jaime Millan, Juan C Tellez, Jose A Hernandez-Campos, Rosario Conejero, Jorge Bolivar, Ricardo Pardal, Francisco J Garcia-Cózar, Enrique Aguado, Albert J R Heck, Mª Carmen Duran-Ruiz
Endothelial progenitor cells (EPCs) constitute a promising alternative in cardiovascular regenerative medicine due to their assigned role in angiogenesis and vascular repair. In response to injury, EPCs promote vascular remodeling by replacement of damaged endothelial cells and/or by secreting angiogenic factors over the damaged tissue. Nevertheless, such mechanisms need to be further characterized. In the current approach we have evaluated the initial response of early EPCs (eEPCs) from healthy individuals after direct contact with the factors released by carotid arteries complicated with atherosclerotic plaques (AP), in order to understand the mechanisms underlying the neovascularization and remodeling properties assigned to these cells...
February 18, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/28219697/effect-of-salvia-miltiorrhiza-root-extract-on-brain-acetylcholinesterase-and-butyrylcholinesterase-activities-their-mrna-levels-and-memory-evaluation-in-rats
#6
Marcin Ozarowski, Przemyslaw L Mikolajczak, Anna Piasecka, Radoslaw Kujawski, Joanna Bartkowiak-Wieczorek, Anna Bogacz, Michal Szulc, Ewa Kaminska, Malgorzata Kujawska, Agnieszka Gryszczynska, Piotr Kachlicki, Waldemar Buchwald, Andrzej Klejewski, Agnieszka Seremak-Mrozikiewicz
Salvia miltiorrhiza (Lamiaceae), one of the most important and popular plants of traditional medicine of Asia, is used for the prevention and treatment of cardiovascular diseases and in central nervous system disturbances. The main aim of this study was to assess the influence of subchronic (28-fold) administration of Salvia miltiorrhiza root extract (SE, 200mg/kg, p.o.) on behavioural activity and memory of rats and to evaluate the activities of cholinesterases (AChE and BuChE) and gene expression levels of AChE and BuChE as well as of beta-secretase (BACE1) in the hippocampus and frontal cortex in vivo...
February 17, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28218249/complexity-variability-assessment-of-nonlinear-time-varying-cardiovascular-control
#7
Gaetano Valenza, Luca Citi, Ronald G Garcia, Jessica Noggle Taylor, Nicola Toschi, Riccardo Barbieri
The application of complex systems theory to physiology and medicine has provided meaningful information about the nonlinear aspects underlying the dynamics of a wide range of biological processes and their disease-related aberrations. However, no studies have investigated whether meaningful information can be extracted by quantifying second-order moments of time-varying cardiovascular complexity. To this extent, we introduce a novel mathematical framework termed complexity variability, in which the variance of instantaneous Lyapunov spectra estimated over time serves as a reference quantifier...
February 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28217453/erectile-dysfunction-in-fit-and-healthy-young-men-psychological-or-pathological
#8
REVIEW
Giulia Rastrelli, Mario Maggi
Epidemiological studies consistently show that prevalence of erectile dysfunction (ED) increases with ageing. Nonetheless, complaints of ED even in younger men are becoming more and more frequent. Healthcare professionals working in Sexual Medicine but even those operating in different clinical contexts might be adequately prepared to answer this increasing requirement. ED in younger men is likely to be overlooked and dismissed without performing any medical assessment, even the most basic ones, such as collection of medical history and physical exam...
February 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28216885/simultaneous-determination-of-eight-phenolic-acids-five-saponins-and-four-tanshinones-for-quality-control-of-compound-preparations-containing-danshen-sanqi-herb-pair-by-hplc-dad
#9
Hong Yao, Xiaomei Huang, Shaoguang Li, Youjia Wu, Xinhua Lin, Peiying Shi
BACKGROUND: The herb-pair, Salviaemiltiorrhizae (Danshen, DS) and Panaxnotoginseng (Sanqi,SQ), often occurs in traditional Chinese medicine prescriptions used for the treatment of cardiovascular diseases in clinics in Asian areas. Many commercial preparations containing the DS-SQ herb-pair were produced by various manufactures with the different production process. The raw materials were from different sources, which raised a challenge to control the quality of the herb-pair medicines...
January 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28216110/the-current-global-state-of-key-lifestyle-characteristics-health-and-economic-implications
#10
REVIEW
Ross Arena, Amy McNeil, Michael Sagner, Andrew P Hills
The chronic disease crisis we currently face must be addressed in rapid fashion. Cardiovascular (CV) and pulmonary diseases, diabetes as well as several forms of cancer are leading causes of morbidity and mortality globally. Collectively, these conditions have a significant impact on the quality of life of individuals, families and communities, placing an unsustainable burden on health systems. There is hope for the chronic disease crisis in that these conditions are largely preventable or can be delayed to much later in life through a timeless medicine, healthy living...
February 16, 2017: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/28215467/cardiovascular-screening-in-low-income-settings-using-a-novel-4-lead-smartphone-based-electrocardiograph-d-heart%C3%A2
#11
Niccolo' Maurizi, Alessandro Faragli, Jacopo Imberti, Nicolò Briante, Mattia Targetti, Katia Baldini, Amadou Sall, Abibou Cisse, Francesca Gigli Berzolari, Paola Borrelli, Fulvio Avvantaggiato, Stefano Perlini, Niccolo' Marchionni, Franco Cecchi, Gianbattista Parigi, Iacopo Olivotto
BACKGROUND: MHealth technologies are revolutionizing cardiovascular medicine. However, a low-cost, user-friendly smartphone-based electrocardiograph is still lacking. D-Heart® is a portable device that enables the acquisition of the ECG on multiple leads which streams via Bluetooth to any smartphone. Because of the potential impact of this technology in low-income settings, we determined the accuracy of D-Heart® tracings in the stratification of ECG morphological abnormalities, compared with 12-lead ECGs...
February 10, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28215156/medicinal-plants-targeting-cardiovascular-diseases-in-view-of-avicenna
#12
Zahra Sobhani, Saeed Reza Nami, Seyed Ahmad Emami, Amirhossein Sahebkar, Behjat Javadi
BACKGROUND: Cardiovascular disease (CVD) is a spectrum of diseases involving the heart and blood vessels, and the first cause of mortality worldwide. Medicinal plants have been used for thousands of years to treat CVD. In Traditional Persian Medicine (TPM), there is a special focus on heart diseases. Avicenna, a Persian physician of the eleventh century compiled a book devoted to this field named "The treatise on cardiac drugs" which is a compendium of TPM knowledge on CVD. Avicenna mentioned 50 cardiovascular active plants and described their therapeutic effects in the treatment of CVDs...
February 14, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28212679/histopathological-study-of-cardiac-lesions-in-methamphetamine-poisoning-related-deaths
#13
Maryam Akhgari, Homeira Mobaraki, Afshar Etemadi-Aleagha
BACKGROUND: Methamphetamine abuse is a worldwide health concern. Methamphetamine causes health hazards in many vital organs. It can cause damage to cardiac tissue via catecholamines release. Methamphetamine related deaths are becoming one of the most important problems in Iran. The purpose of the present study was to determine cardiac pathology in methamphetamine poisoning-related deaths. METHODS: The study included 100 cases of methamphetamine poisoning-related deaths and 100 cases as control group...
February 17, 2017: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/28209228/big-data-health-informatics-and-the-future-of-cardiovascular-medicine
#14
EDITORIAL
Joonseok Kim
No abstract text is available yet for this article.
February 21, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28207177/quaking-is-a-key-regulator-of-endothelial-cell-differentiation-neovascularization-and-angiogenesis
#15
Amy Cochrane, Sophia Kelaini, Marianna Tsifaki, James Bojdo, Marta Vilà-González, Daiana Drehmer, Rachel Caines, Corey Magee, Magdalini Eleftheriadou, Yanhua Hu, David Grieve, Alan W Stitt, Lingfang Zeng, Qingbo Xu, Andriana Margariti
The capability to derive endothelial cell (ECs) from induced Pluripotent Stem (iPS) cells holds huge therapeutic potential for cardiovascular disease. Objective- This study elucidates the precise role of the RNA-binding protein Quaking isoform 5 (QKI-5) during EC differentiation from both mouse and human iPS cells and dissects how RNA-binding proteins can improve differentiation efficiency towards cell therapy for important vascular diseases. iPS cells represent an attractive cellular approach for regenerative medicine today since they can be used to generate patient-specific therapeutic cells towards autologous cell therapy...
February 16, 2017: Stem Cells
https://www.readbyqxmd.com/read/28204303/advocating-cardiovascular-precision-medicine-with-p2y12-receptor-inhibitors
#16
Max-Paul Winter, Erik L Grove, Raffaele De Caterina, Diana A Gorog, Ingo Ahrens, Tobias Geisler, Paul A Gurbel, Udaya Tantry, Eliano P Navarese, Jolanta M Siller-Matula
No abstract text is available yet for this article.
February 15, 2017: European Heart Journal. Cardiovascular Pharmacotherapy
https://www.readbyqxmd.com/read/28203292/the-waist-circumference-adjusted-associations-between-hyperuricemia-and-other-lifestyle-related-diseases
#17
Taiju Miyagami, Hirohide Yokokawa, Kazutoshi Fujibayashi, Toshiaki Gunji, Noriko Sasabe, Mitsue Okumura, Kimiko Iijima, Toshio Naito
BACKGROUND: Few studies have assessed the associations between hyperuricemia and lifestyle-related diseases after adjusting for waist circumference (WC) and sex. METHODS: This cross-sectional study included 33,498 Japanese individuals, and was conducted at the Center for Preventive Medicine, NTT Kanto Medical Center, Tokyo, from May 2006 to March 2015. Hyperuricemia was defined as a uric acid level of >7 mg/dl in men; >6 mg/dl in women. Metabolic syndrome (Mets) components were defined using the Japanese criteria for Mets...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28197520/a-mini-review-on-the-most-important-effective-medicinal-plants-to-treat-hypertension-in-ethnobotanical-evidence-of-iran
#18
REVIEW
Babak Baharvand-Ahmadi, Majid Asadi-Samani
Nowadays, cardiovascular diseases are highly prevalent in human communities. Hypertension is a multifactorial disease which causes a mortality twice higher than general population. Given the fact that medicinal plants have long been used to treat hypertension and are currently being administered for this disease, we sought to report the mostly effective and important medicinal plants on hypertension therapy in ethno-botanical evidence of Iran. In this study, hypertension, Iran, ethno-botany, medicinal plants, and traditional medicine were used as key words to search in Web of Science, PubMed, Scopus, EBSCO and EMBASE to select relevant articles...
2017: J Nephropharmacol
https://www.readbyqxmd.com/read/28197101/the-combination-of-three-components-derived-from-sheng-maisan-protects-myocardial-ischemic-diseases-and-inhibits-oxidative-stress-via-modulating-mapks-and-jak2-stat3-signaling-pathways-based-on-bioinformatics-approach
#19
Fang Li, Yu Zhang, Donglin Zeng, Yu Xia, Xiaoxue Fan, Yisha Tan, Junping Kou, Boyang Yu
GRS is a drug combination of three components including ginsenoside Rb1, ruscogenin and schisandrin. It derived from the well-known TCM formula Sheng MaiSan, a widely used traditional Chinese medicine for the treatment of cardiovascular diseases in clinic. The present study illuminates its underlying mechanisms against myocardial ischemic diseases based on the combined methods of bioinformatic prediction and experimental verification. A protein database was established through constructing the drug-protein network...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28196737/statin-use-and-all-cause-and-cancer-mortality-biobank-japan-cohort
#20
Hiroshi Yokomichi, Akiko Nagai, Makoto Hirata, Akiko Tamakoshi, Yutaka Kiyohara, Yoichiro Kamatani, Kaori Muto, Toshiharu Ninomiya, Koichi Matsuda, Michiaki Kubo, Yusuke Nakamura, Zentaro Yamagata
BACKGROUND: Statins are the first-line agents used to treat patients with high serum low-density lipoprotein cholesterol levels, thus reducing the risk of death from arterial sclerotic cardiovascular disease; however, little is known about the effects of non-statin pharmacological interventions on mortality as well as about the potential protective effects of statin use against cancer death. This work aimed to compare all-cause and cancer mortality among patients with hyperlipidaemia who did and did not receive statin treatment...
February 11, 2017: Journal of Epidemiology
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