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https://www.readbyqxmd.com/read/27843711/iron-overload-induced-death-of-osteoblasts-in-vitro-involvement-of-the-mitochondrial-apoptotic-pathway
#1
Qing Tian, Shilei Wu, Zhipeng Dai, Jingjing Yang, Jin Zheng, Qixin Zheng, Yong Liu
BACKGROUND: Iron overload is recognized as a new pathogenfor osteoporosis. Various studies demonstrated that iron overload could induce apoptosis in osteoblasts and osteoporosis in vivo. However, the exact molecular mechanisms involved in the iron overload-mediated induction of apoptosis in osteoblasts has not been explored. PURPOSE: In this study, we attempted to determine whether the mitochondrial apoptotic pathway is involved in iron-induced osteoblastic cell death and to investigate the beneficial effect of N-acetyl-cysteine (NAC) in iron-induced cytotoxicity...
2016: PeerJ
https://www.readbyqxmd.com/read/27730356/cancer-survivor-study-casus-on-colorectal-patients-longitudinal-study-on-physical-activity-fitness-nutrition-and-its-influences-on-quality-of-life-disease-recurrence-and-survival-rationale-and-design
#2
Luisa Soares-Miranda, Sandra Abreu, Marco Silva, Armando Peixoto, Rosa Ramalho, Pedro Correia da Silva, Carla Costa, João Paulo Teixeira, Carla Gonçalves, Pedro Moreira, Jorge Mota, Guilherme Macedo
PURPOSE: Evidence suggests that being physically active in combination with a healthy diet contributes to diminish colorectal cancer risk. However, if this is true for colorectal cancer primary prevention, the same is not clear for its recurrence after colorectal cancer treatments. Data on cancer survival are scarce, and there is a need for greater attention on these survivors' lifestyle behavior. This manuscript describes rationale and design of the Cancer Survival Study (CASUS) on colorectal patients, a longitudinal observational study with the aim of investigating how physical activity, physical fitness, and dietary intake are related with their quality of life, disease recurrence, and survival...
October 11, 2016: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/27515602/a-systematic-appraisal-of-the-types-of-ten-species-of-otostigmus-parotostigmus-scolopendromorpha-scolopendridae-otostigminae
#3
Amazonas Chagas-Jr
The type material of O. brunneus Chamberlin, 1921, O. casus Chamberlin, 1914, O. clavifer Chamberlin, 1921, O. cooperi Chamberlin, 1942, O. occidentalis Meinert, 1886, O. rex Chamberlin, 1914, O. samacus Chamberlin, 1944, O. scabricauda (Humbert & Saussure, 1870), O. suitius Chamberlin, 1914, and O. therezopolis Chamberlin, 1944, are revised. The types of O. casus, O. cooperi, O. occidentalis, O. rex, O. samacus, O. scabricauda, and O. therezopolis are illustrated for the first time. Among the species examined, O...
2016: Zootaxa
https://www.readbyqxmd.com/read/26279053/combination-of-european-system-for-cardiac-operative-risk-evaluation-euroscore-and-cardiac-surgery-score-casus-to-improve-outcome-prediction-in-cardiac-surgery
#4
Fabian Doerr, Matthias B Heldwein, Ole Bayer, Anton Sabashnikov, Alexander Weymann, Pascal M Dohmen, Thorsten Wahlers, Khosro Hekmat
BACKGROUND We hypothesized that the combination of a preoperative and a postoperative scoring system would improve the accuracy of mortality prediction and therefore combined the preoperative 'additive EuroSCORE' (European system for cardiac operative risk evaluation) with the postoperative 'additive CASUS' (Cardiac Surgery Score) to form the 'modified CASUS'. MATERIAL AND METHODS We included all consecutive adult patients after cardiac surgery during January 2007 and December 2010 in our prospective study...
2015: Medical Science Monitor Basic Research
https://www.readbyqxmd.com/read/26137928/inclusion-of-icu-day-in-a-logistic-scoring-system-improves-mortality-prediction-in-cardiac-surgery
#5
Fabian Doerr, Matthias B Heldwein, Ole Bayer, Anton Sabashnikov, Alexander Weymann, Pascal M Dohmen, Thorsten Wahlers, Khosro Hekmat
BACKGROUND Prolonged intensive care unit (ICU) stay is a predictor of mortality. The length of ICU stay has never been considered as a variable in an additive scoring system. How could this variable be integrated into a scoring system? Does this integration improve mortality prediction? MATERIAL AND METHODS The 'modified CArdiac SUrgery Score' (CASUS) was generated by implementing the length of stay as a new variable to the 'additive CASUS'. The 'logistic CASUS' already considers this variable. We defined outcome as ICU mortality and statistically compared the three CASUS models...
2015: Medical Science Monitor Basic Research
https://www.readbyqxmd.com/read/26134333/scoring-systems-for-outcome-prediction-in-a-cardiac-surgical-intensive-care-unit-a-comparative-study
#6
COMPARATIVE STUDY
Themistocles Exarchopoulos, Efstratia Charitidou, Panagiotis Dedeilias, Christos Charitos, Christina Routsi
BACKGROUND: Most scoring systems used to predict clinical outcome in critical care were not designed for application in cardiac surgery patients. OBJECTIVES: To compare the predictive ability of the most widely used scoring systems (Acute Physiology and Chronic Health Evaluation [APACHE] II, Simplified Acute Physiology Score [SAPS] II, and Sequential Organ Failure Assessment [SOFA]) and of 2 specialized systems (European System for Cardiac Operative Risk Evaluation [EuroSCORE] II and the cardiac surgery score [CASUS]) for clinical outcome in patients after cardiac surgery...
July 2015: American Journal of Critical Care: An Official Publication, American Association of Critical-Care Nurses
https://www.readbyqxmd.com/read/25871786/e-learning-in-urology-implementation-of-the-learning-and-teaching-platform-casus%C3%A2-do-virtual-patients-lead-to-improved-learning-outcomes-a-randomized-study-among-students
#7
RANDOMIZED CONTROLLED TRIAL
Anna-Teresa Schneider, Peter Albers, Volker Müller-Mattheis
BACKGROUND: E-learning is playing an increasing role in medical education, supporting a problem-based and practical oriented education without putting patients at risk and compensating for the decrease in instructor-centered teaching. Not much research has been done concerning learning effects and reaction on behalf of the students. METHODS: We created computer-based cases for four important diagnoses in urology using the authoring system CASUS®. Fourth-year medical school students were randomized into two groups: (1) the CASUS® group, using the online cases for preparation, and (2) the book group, using a textbook...
2015: Urologia Internationalis
https://www.readbyqxmd.com/read/24922629/inefficacy-of-therapeutic-cancer-vaccines-and-proposed-improvements-casus-of-prostate-cancer
#8
REVIEW
John J L Jacobs, Chantal Snackey, Albert A Geldof, Dainius Characiejus, R Jeroen A Van Moorselaar, Willem Den Otter
Prophylactic vaccination is arguably the most effective medical preventative method. After local inoculation, vaccines induce antigen-specific systemic immunity, protecting the whole body. Systemic antitumour immunity can cure advanced cancer, but will therapeutic vaccination suffice? A vaccine for castration-refractory prostate cancer (CRPC) was approved by regulatory authority, but its evidence is disputed. We critically reviewed the clinical efficacy of therapeutic cancer vaccines for prostate cancer, including the results of 31 clinical studies employing vaccines-only, and another 10 studies combining vaccines with immune co-stimulation...
June 2014: Anticancer Research
https://www.readbyqxmd.com/read/24881264/-primary-failure-of-eruption-diagnostics-treatment-casus-and-review-of-literature
#9
REVIEW
M S Milani, M A R Kuijpers
Primary failure of eruption is a rare eruption disorder of above all, the permanent second and sometimes the first molars. It is characterized by infra occlusion of the molars resulting in a severe lateral open bite. Primary failure of eruption is a disorders which affects all molars distal to the most mesial involved tooth. Diagnosis is possible both clinically and with radiographs. A panoramic radiograph combined with clinical findings of impaction or infra occlusion can confirm the suspicion of primary failure of eruption...
April 2014: Nederlands Tijdschrift Voor Tandheelkunde
https://www.readbyqxmd.com/read/24595808/the-adolescent-mentalization-based-integrative-treatment-ambit-approach-to-outcome-evaluation-and-manualization-adopting-a-learning-organization-approach
#10
Peter Fuggle, Dickon Bevington, Liz Cracknell, James Hanley, Suzanne Hare, John Lincoln, Garry Richardson, Nina Stevens, Heather Tovey, Sally Zlotowitz
AMBIT (Adolescent Mentalization-Based Integrative Treatment) is a developing team approach to working with hard-to-reach adolescents. The approach applies the principle of mentalization to relationships with clients, team relationships and working across agencies. It places a high priority on the need for locally developed evidence-based practice, and proposes that outcome evaluation needs to be explicitly linked with processes of team learning using a learning organization framework. A number of innovative methods of team learning are incorporated into the AMBIT approach, particularly a system of web-based wiki-formatted AMBIT manuals individualized for each participating team...
July 2015: Clinical Child Psychology and Psychiatry
https://www.readbyqxmd.com/read/24448949/-inequities-in-health-the-case-of-dengue
#11
Veerle Vanlerberghe, Kristien Verdonck
Impoverished populations carry a disproportionately high share of the burden of neglected tropical diseases, including dengue. The burden of dengue is high among poor people because they often live in communities where mosquito vectors are abundant, because they use less vector-human barrier methods, and because interventions tend to be less effective in disadvantaged populations. We believe that a better understanding and management of the "causes behind the causes" of dengue would lead to more equitable and more effective control strategies...
October 2013: Revista Peruana de Medicina Experimental y Salud Pública
https://www.readbyqxmd.com/read/24273929/an-educational-web-based-external-quality-assessment-outcome-and-evaluation-first-experiences-with-urinary-sediment-and-hemostaseology
#12
Corneliac Schürer-Maly, William Graham Wood, Rosanna Falbo, Paolo Brambilla, Christian Heller, Patrick Schwarz, Dirk Illigen, Martin Adler, Nicole Heitzmann, Daniel Bauer, Martin Fischer, Michael Spannagl
External quality assessment is a standard procedure for many medical laboratories, especially those accredited according to ISO 15189. INSTAND has developed web-based quality control surveys (WQ) with integrated case-based learning in collaboration with the Institute for Teaching and Educational Research in Health Sciences (IDBG), University of Witten/Herdecke. The WQs were presented via a weblink using the learning management system CASUS. Laboratories registered with INSTAND for conventional EQAs covering the same topic were invited to participate in the WQs...
2013: Clinical Laboratory
https://www.readbyqxmd.com/read/23745078/introduction-of-virtual-patients-onto-a-final-year-anesthesia-course-hong-kong-experience
#13
Joseph Yc Leung, Lester Ah Critchley, Alex Lk Yung, Shekhar M Kumta
e-Learning has revolutionized the way in which undergraduate medical education is delivered. One e-learning tool of note is the virtual patient (VP), a type of computer software that simulates real-life clinical scenarios, in which the learner emulates the role of health care provider to obtain the history, conduct examination, and make diagnoses and management decisions. VPs have been in use since 1993. Early designs were based on serial screen-cards of patient history, examination, investigations, diagnoses, treatment, and outcome, which the learner explored...
2011: Advances in Medical Education and Practice
https://www.readbyqxmd.com/read/23709557/an-unusual-complication-in-ulcerative-colitis-during-treatment-with-azathioprine-and-infliximab-isospora-belli-as-casus-belli
#14
Juergen Stein, Egbert Tannich, Franz Hartmann
The treatment of ulcerative colitis is based on systemic corticosteroids, immunomodulators such as cyclosporine and azathioprine and TNF-α antagonists. Patients undergoing such immunosuppressive treatment are more susceptible for infectious pathogens. Here, we report the case of a patient with a 13-year history of ulcerative colitis, treated initially with systemic corticosteroids in combination with immunomodulators, and subsequently with infliximab. The patient presented with severe watery diarrhoea, abdominal cramps, weight loss and low-grade fever...
2013: BMJ Case Reports
https://www.readbyqxmd.com/read/23650786/spontaneous-liver-bleeding-in-a-patient-with-congenital-arterioportal-fistulisation-presentation-of-a-casus-princeps-and-review-of-the-literature
#15
REVIEW
Toon Steinhauser, Sven Francque, Jan Kunnen, Jan Holvoet
We present the first case reported in the literature describing spontaneous liver haemorrhage due to diffuse arterioportal fistulae. A 48-year old Caucasian woman was admitted to the hospital complaining of acute epigastric pain eradiating to the right shoulder. Patient never had any penetrating or blunt abdominal trauma in the past nor any intervention on the liver. CT scan of the abdomen revealed a subcapsular haematoma originating from two bleeding sites in the right liver lobe. Arteriography of the common hepatic artery showed opacification of the portal branches, indicative of an arterioportal fistula...
March 2013: Acta Gastro-enterologica Belgica
https://www.readbyqxmd.com/read/23500735/right-hemothorax-an-unusual-presentation-of-a-barrett-s-ulcer-perforation
#16
J H Volders, B Witteman, A H Mulder, A Bosch, Ph M Kruyt
INTRODUCTION: Despite improvements in detection and surgical techniques perforation of the esophagus are lifethreatening. In this case report a rare presentation esophageal perforation due to Barrett's ulceration into an aortic vessel is described. PRESENTATION OF CASE: We report a 42 year old man with known Barrett's esophagus presenting with abdominal pain. Further investigations showed an active intrathoracal hemorrhage due to esophageal perforation at exactly the same site of the known Barret's ulcer one year before...
2013: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/23294745/clinical-decision-making-a-pilot-e-learning-study
#17
Martin Abendroth, Sigrid Harendza, Martin Riemer
BACKGROUND: As many medical schools focus on student-centred learning strategies, e-learning provides a useful approach to foster clinical decision-making skills in a case-based way. We developed an e-learning module based on real patient cases for final-year students as a self-directed studying tool. METHODS: Ten patient cases were developed from patients treated in the emergency room. Original documents were integrated into the virtual patient system CASUS(®) ...
February 2013: Clinical Teacher
https://www.readbyqxmd.com/read/22874335/new-approaches-to-linking-clinical-guidelines-to-virtual-patients
#18
Andrzej A Kononowicz, Inga Hege, Paweł Krawczyk, Nabil Zary
An often reported challenge of evidence-based medicine concerns increasing use of clinical guidelines in practice. One of the proposed improvements is to promote guidelines by presenting them in conjunction with virtual patients. Three approaches to linking clinical guidelines to virtual patients are presented in this paper: (1) guidelines as a source for generating virtual patients; (2) guidelines hyper-flowchart as a virtual patient progress indicator; (3) guidelines flowchart reconstruction as a learning activity in virtual patient systems...
2012: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/22475805/outcome-prediction-in-cardiac-surgery-the-first-logistic-scoring-model-for-cardiac-surgical-intensive-care-patients
#19
F Doerr, A M A Badreldin, E M Bender, M B Heldwein, T Lehmann, O Bayer, B B Brehm, M Ferrari, K Hekmat
BACKGROUND: In the process of risk stratification, a logistic calculation of mortality risk in percentage is easier to interpret. Unfortunately, there is no reliable logistic model available for postoperative intensive care patients. The aim of this study was to present the first logistic model for postoperative mortality risk stratification in cardiac surgical intensive care units. This logistic version is based on our previously presented and established additive model (CASUS) that proved a very high reliability...
August 2012: Minerva Anestesiologica
https://www.readbyqxmd.com/read/22325108/-co-operative-learning-in-clinical-radiology-clicr-introducing-a-novel-teaching-concept-in-radiology-in-the-context-of-competence-oriented-curricula
#20
Axel Scherer, Patric Kröpil, Philipp Heusch, Philipp Sewerin, Dirk Blondin, Rotem S Lanzman, Falk Miese, Stefanie Ritz-Timme, Matthias Schneider, Gerald Antoch
INTRODUCTION: Medical curricula are currently being reformed in order to establish interactive and case-based teaching concepts. Here we present a novel radiological course combining several innovative training components and report our initial experience with its practical implementation and the students' evaluation of it. METHODS: A novel longitudinal radiological teaching course was established, integrated with the medical curriculum and evaluated systematically...
2012: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
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