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https://www.readbyqxmd.com/read/29352771/severe-cutaneous-adverse-reactions-due-to-inappropriate-medication-use
#1
G Chaby, L Valeyrie-Allanore, T A Duong, B Lebrun-Vignes, B Milpied, B Sassolas, F Tetart, P Wolkenstein, O Chosidow, L Fardet
BACKGROUD: The proportion of severe cutaneous adverse reactions (SCARs) that could be avoided if medication use was consistent with good medical practice is unknown. OBJECTIVES: To estimate the proportion of SCARs related to inappropriate medication use. METHODS: Retrospective study of all validated SCARs collected in a French registry between 2003 and 2016. For each case, all plausible drugs suspected to induce SCARs (i.e., not just the drug regarded as "the most probable") were considered regarding three causes of preventability: (1) prescription for an inappropriate indication, (2) unintentional rechallenge despite a previous allergy to the drug, or (3) self-medication with prescription medicines...
January 20, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29352756/influence-of-defect-locations-and-nitrogen-doping-configurations-on-the-mechanical-properties-of-armchair-graphene-nanoribbons
#2
Ahmet Emin Senturk, Ahmet Sinan Oktem, Alp Er S Konukman
The effect of defect locations on the mechanical properties of armchair graphene nanoribbons (AGNRs) and the various configurations of nitrogen (N) doping on the mechanical properties of AGNRs were examined using molecular dynamics (MD) simulations. The variation of the Young's modulus (YM) and the ultimate tensile strength (UTS) of pyridinic-N, graphitic-N, and pyrrolic-N by increasing the concentration of N doping was investigated. The results of MD simulations show that the defect location has a significant effect on the UTS and failure strain (FS) of AGNRs in both vertical and horizontal directions...
January 19, 2018: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/29352748/use-of-e-learning-in-clinical-clerkships-effects-on-acquisition-of-dermatological-knowledge-and-learning-processes
#3
Frederike Fransen, Herm Martens, Ivo Nagtzaam, Sylvia Heeneman
Objectives: To obtain a deeper understanding of how the e-learning program, Education in Dermatology (ED), affects the acquisition of dermatological knowledge and the underlying learning processes of medical students in their clinical phase. Methods: The study used a mixed method design with a convergent parallel collection of data. Medical students (n=62) from Maastricht University (The Netherlands) were randomized to either a conventional teaching group (control group n=30) or conventional teaching plus the e-learning program (application on smartphone) group (e-learning group n=32)...
January 17, 2018: International Journal of Medical Education
https://www.readbyqxmd.com/read/29352746/the-common-bean-cok-4-and-the-arabidopsis-fer-kinase-domain-share-similar-function-in-plant-growth-and-defense
#4
Rafhael Felipin Azevedo, Maria Celeste Gonçalves Vidigal, Paula Rodrigues Oblessuc, Maeli Melotto
Receptor-like kinases are membrane proteins that can be shared by diverse signaling pathways. Among them, the Arabidopsis thaliana FERONIA (FER) plays a role in the balance between distinct signals to control growth and defense. We have found that COK-4, a putative kinase encoded in the common bean anthracnose resistance locus Co-4 that is transcriptionally regulated during immune response, is highly similar to the kinase domain of FER. To assess whether COK-4 is a functional ortholog of FER, we expressed COK-4 in the wild type Col-0 and the fer-5 mutant of Arabidopsis and evaluated FER-associated traits...
January 20, 2018: Molecular Plant Pathology
https://www.readbyqxmd.com/read/29352743/co-transplantation-of-adipose-tissue-derived-stromal-cells-and-olfactory-ensheathing-cells-for-spinal-cord-injury-repair
#5
Eduardo D Gomes, Sofia S Mendes, Rita C Assunção-Silva, Fábio G Teixeira, Ana O Pires, Sandra I Anjo, Bruno Manadas, Hugo Leite-Almeida, Jeffrey M Gimble, Nuno Sousa, Angelo C Lepore, Nuno A Silva, António J Salgado
Patients suffering from Spinal Cord Injury (SCI) still have a dismal prognosis. Despite all the efforts developed in this area, currently there are no effective treatments. Therefore, cell therapies have been proposed as a viable alternative to the current treatments employed. Adipose tissue-derived Stem Cells (ASCs) and Olfactory Ensheathing Cells (OECs) have been used with promising results in different models of SCI, namely due to the regenerative properties of the secretome of the first, and the guidance capability of the second...
January 20, 2018: Stem Cells
https://www.readbyqxmd.com/read/29352740/coordinates-for-the-somatosensory-homunculus
#6
Marc H Schieber
In the text surrounding their drawing of the simiusculus (little monkey), Clinton Woolsey and colleagues wrote (Woolsey et al. 1952), "It must be emphasized, however, that this diagram is an inadequate representation of the localization pattern, since in a line drawing one cannot indicate the successive overlap which is so characteristic a feature of cortical representation, not only in the motor but also in the sensory areas." This article is protected by copyright. All rights reserved.
January 20, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29352732/long-term-effects-of-crizotinib-in-alk-positive-tumors-excluding-nsclc-a-phase-1b-open-label-study
#7
Carlo Gambacorti-Passerini, Sergey Orlov, Li Zhang, Fadi Braiteh, Huiqiang Huang, Taito Esaki, Keizo Horibe, Jin-Seok Ahn, Joseph T Beck, William Jeffrey Edenfield, Yuankai Shi, Matthew Taylor, Kenji Tamura, Brian A Van Tine, Shang-Ju Wu, Jolanda Paolini, Paulina Selaru, Tae Min Kim
Crizotinib, an inhibitor of anaplastic lymphoma kinase (ALK), MET, and ROS1, is approved for treatment of patients with ALK-positive or ROS1-positive advanced non-small-cell lung cancer (NSCLC). However, ALK rearrangements are also implicated in other malignancies, including anaplastic large-cell lymphoma and inflammatory myofibroblastic tumors (IMTs). In this ongoing, multicenter, single-arm, open-label phase 1b study (PROFILE 1013; NCT01121588), patients with ALK-positive advanced malignancies other than NSCLC were to receive a starting dose of crizotinib 250 mg twice daily...
January 20, 2018: American Journal of Hematology
https://www.readbyqxmd.com/read/29352724/indications-for-starting-art
#8
Cristina Mussini, Andrea Cossarizza
No abstract text is available yet for this article.
January 15, 2018: Lancet HIV
https://www.readbyqxmd.com/read/29352722/daily-intake-of-mucuna-pruriens-in-advanced-parkinson-s-disease-a-16-week-noninferiority-randomized-crossover-pilot-study
#9
Roberto Cilia, Janeth Laguna, Erica Cassani, Emanuele Cereda, Benedetta Raspini, Michela Barichella, Gianni Pezzoli
BACKGROUND: Thousands of individuals with Parkinson's disease (PD) in low-income countries have limited access to marketed levodopa preparations. Mucuna pruriens (MP), a levodopa-containing leguminous plant growing in tropical areas, may be a sustainable alternative therapy for indigent patients. Single-dose intake of MP proved noninferior to marketed levodopa preparations. METHODS: Fourteen PD patients with motor fluctuations and dyskinesias received MP powder (obtained from roasted seeds) and marketed levodopa/carbidopa (LD/CD) in a randomized order and crossover design over a 16-week period...
January 11, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29352710/changes-in-hepg2-spheroid-behavior-induced-by-differences-in-the-gap-distance-between-spheroids-in-a-micropatterned-culture-system
#10
Daisuke Miyamoto, Takuya Hara, Ai Hyakutake, Kohji Nakazawa
Micropatterning is a promising technique for modulating culture environments. In this study, we investigated the effect of spheroid separation distance on their properties in a micropatterned chip of HepG2 spheroids. The basic chip design consisted of 37 collagen spots (300 μm in diameter) in a hexagonal arrangement on a glass substrate; the region without collagen-spots was modified by polyethylene glycol to create the non-adhesive surface. Three similar chips were fabricated with gap distances between collagen-spots of 500, 1000, and 1500 μm...
January 15, 2018: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/29352706/environmental-conditions-in-health-care-facilities-in-low-and-middle-income-countries-coverage-and-inequalities
#11
Ryan Cronk, Jamie Bartram
Safe environmental conditions and the availability of standard precaution items are important to prevent and treat infection in health care facilities (HCFs) and to achieve Sustainable Development Goal (SDG) targets for health and water, sanitation, and hygiene. Baseline coverage estimates for HCFs have yet to be formed for the SDGs; and there is little evidence describing inequalities in coverage. To address this, we produced the first coverage estimates of environmental conditions and standard precaution items in HCFs in low- and middle-income countries (LMICs); and explored factors associated with low coverage...
January 11, 2018: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/29352697/venous-ports-in-infants
#12
Michael Acord, Anne Marie Cahill, Ganesh Krishnamurthy, Seth Vatsky, Marc Keller, Abhay Srinivasan
PURPOSE: To evaluate technical success and the incidences of, and risk factors for, mechanical and infectious complications of venous port placement in infants. MATERIALS AND METHODS: This was a retrospective single-institution cohort study of port placement in infants (age < 1 y) from January 2006 through June 2016 (mean age, 7.5 mo ± 3.3; mean weight, 8.1 kg ± 1.9). Age, weight, sex, side of placement, tip position, and indication for placement (chemotherapy vs other) were recorded...
January 15, 2018: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29352681/no-consensus-for-femoral-head-impaction-technique-in-surgeon-education-materials-from-orthopedic-implant-manufacturers
#13
Brian J McGrory, Eric Ng
BACKGROUND: Prior studies indicate that one factor that may contribute to total hip arthroplasty failure due to mechanically assisted crevice corrosion at the femoral head-trunnion junction is the method of femoral head fixation. METHODS: Up-to-date on-line surgical technique guides describing fixation of the prosthetic femoral head of common implants of the 4 largest manufacturers as well as 2 minor manufacturers were identified. The information given regarding preparation and fixation of the femoral head was evaluated and compared...
December 30, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29352673/chest-pain-in-a-young-female
#14
Paul S Basel, Daniel Reschke, Michael D April
Acute Coronary Syndrome (ACS) is a common diagnosis in the emergency department (ED), the most severe manifestation of which is ST elevation on electrocardiogram (ECG). ST elevation reflects obstruction of flow through the coronary arteries, most commonly due to coronary atherosclerotic plaque rupture. However, alternative causes of coronary obstruction causing ST elevation are possible. Spontaneous coronary artery dissection (SCAD) is an unusual cause of ST elevation in ED patients which providers may encounter in patients without traditional atherosclerosis risk factors...
January 11, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29352638/the-evaluation-of-the-hydrophilic-hydrophobic-interactions-and-their-effect-in-water-methanol-solutions-a-study-in-terms-of-the-thermodynamic-state-functions-in-the-frame-of-the-transition-state-theory
#15
Francesco Mallamace, Carmelo Corsaro, Sveva Longo, Sow-Hsin Chen, Domenico Mallamace
Aqueous solutions of amphiphilic molecules are characterized by the competition between hydrophilic and hydrophobic interactions. These interactions have a different energetic dependence with the temperature. Whereas hydrophilic interactions have been well characterized, a complete theory for the hydrophobic ones is still lacking as well as the comprehension of the effect that the solvent exerts on the solute and vice versa. In this paper from the measured relaxation time, we evaluated the thermodynamic state functions of water-methanol solutions in the frame of the transition state theory...
January 11, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29352634/factors-influencing-the-recycling-rate-under-the-volume-based-waste-fee-system-in-south-korea
#16
Seejeen Park
Since the early 2000s, the Republic of Korea (South Korea) has maintained its top-rank status for its municipal solid waste (MSW) recycling rate among OECD (Organization for Economic Cooperation and Development) member countries. The volume-based waste fee system (VWF) has been considered to be the major factor contributing to the high recycling performance, and extant research has verified the positive relationship between VWF adoption and the MSW recycling rate. Nevertheless, there exists a gap in the literature, as past research has focused more on testing the positive effects of VWF rather than on investigating the determinants of recycling rates after the adoption of VWF...
January 15, 2018: Waste Management
https://www.readbyqxmd.com/read/29352631/we-could-learn-much-more-from-1918-pandemic-the-mis-fortune-of-research-relying-on-original-death-certificates
#17
Wladimir J Alonso, Francielle C Nascimento, Gerardo Chowell, Cynthia Schuck-Paim
PURPOSE: The analysis of historical death certificates has enormous potential for understanding how the health of populations was shaped by diseases and epidemics and by the implementation of specific interventions. In Brazil, the systematic archiving of mortality records was initiated only in 1944-hence the analysis of death registers before this time requires searching for these documents in public archives, notaries, parishes, and especially ancient cemeteries, which are often the only remaining source of information about these deaths...
January 9, 2018: Annals of Epidemiology
https://www.readbyqxmd.com/read/29352630/surgical-damage-to-the-lymphatic-system-promotes-tumor-growth-via-impaired-adaptive-immune-response
#18
Yoshiyuki Nakamura, Yasuhiro Fujisawa, Naoko Okiyama, Rei Watanabe, Ryota Tanaka, Yosuke Ishitsuka, Hideaki Tahara, Manabu Fujimoto
BACKGROUND: Both lymph nodes (LNs) and lymphatic channels from primary sites to regional LNs are critical for initiation of adaptive immunity. However, as LNs are common metastatic sites in skin cancers, LN biopsies or dissections are frequently performed. In addition, reconstructive skin flaps after tumor resection may damage lymphatic flow from primary sites to regional LNs. OBJECTIVE: This study was designed to investigate the effect on tumor progression by such surgeries...
December 29, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29352627/indications-and-limits-of-stereoelectroencephalography-seeg
#19
REVIEW
Lorella Minotti, Alexandra Montavont, Julia Scholly, Louise Tyvaert, Delphine Taussig
Epilepsy surgery is now an accepted treatment to achieve seizure control in carefully selected patients, both children and adults, suffering from drug-resistant focal epilepsy. Although surgical strategies can often be defined on the basis of non-invasive diagnostic procedures, and despite the recent advances in this field, an increasing number of more complex cases requires invasive EEG (iEEG) to provide precise information on the localization of the epileptogenic zone (EZ), its relationships with eloquent cortex (EC), and the feasibility of a tailored surgical resection...
January 15, 2018: Neurophysiologie Clinique, Clinical Neurophysiology
https://www.readbyqxmd.com/read/29352619/quantitative-evaluation-of-enzyme-induced-porcine-articular-cartilage-degeneration-based-on-observation-of-entire-cartilage-layer-using-ultrasound
#20
Jingchen Zhang, Liying Xiao, Lingying Tong, Chao Wan, Zhixiu Hao
Enzyme-induced articular cartilage degeneration resembling osteoarthritis was evaluated using a newly defined acoustic parameter, the "averaged magnitude ratio" (AMR), which has been suggested as an indicator of articular cartilage degeneration. In vitro experiments were conducted on porcine cartilage samples digested with trypsin for 2 h (n = 10) and 4 h (n = 13) and healthy control samples (n = 13). AMR was determined with 15- and 25-MHz ultrasound, and the integrated reflection coefficient (IRC) and apparent integrated backscattering coefficient (AIB) were also calculated for comparison...
January 15, 2018: Ultrasound in Medicine & Biology
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