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https://www.readbyqxmd.com/read/28821608/the-transmembrane-domain-of-the-p75-neurotrophin-receptor-stimulates-phosphorylation-of-the-trkb-tyrosine-kinase-receptor
#1
Khalil Saadipour, Michael MacLean, Sean Pirkle, Solav Ali, Maria Luisa Lopez-Redondo, David L Stokes, Moses V Chao
The function of protein products generated from intramembraneous cleavage by the γ-secretase complex is not well defined. The γ-secretase complex is responsible for the cleavage of several transmembrane proteins, most notably the amyloid precursor protein which results in Aβ, a transmembrane (TM) peptide. Another protein that undergoes a very similar γ-secretase cleavage is the p75 neurotrophin receptor. However, the fate of the cleaved p75 TM domain is unknown. p75 neurotrophin receptor is highly expressed during early neuronal development and regulates survival and process formation of neurons...
August 17, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28821292/the-relationship-between-obesity-and-body-compositions-with-respect-to-the-timing-of-puberty-in-chongqing-adolescents-a-cross-sectional-study
#2
Fang He, Peiyu Guan, Qin Liu, Donna Crabtree, Linli Peng, Hong Wang
BACKGROUND: It is well known that excess adiposity during childhood may influence pubertal development. However, the extent to which body compositions vary in throughout puberty in boys and girls is currently unknown. The aim of this study was to investigate whether obesity and body compositions correlate with the timing of puberty in boys and girls. METHODS: By random cluster sampling, our study analyzed data from 1472 students (690 girls, 782 boys) aged 6-17 years from two schools in the Chongqing area...
August 18, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28819854/flow-cytometric-detection-of-circulating-tumor-cells-using-a-candidate-stem-cell-marker-p75-neurotrophin-receptor-p75ntr
#3
Tomoyuki Okumura, Tetsuji Yamaguchi, Toru Watanabe, Takuya Nagata, Yutaka Shimada
The most widely studied detection for circulating tumor cells (CTCs) in peripheral blood of cancer patients has been based on immunomagnetic enrichment using antibodies against epithelial cell adhesion molecule (EpCAM), which is overexpressed in epithelial cells. A neurotrophin receptor p75 (p75NTR) is expressed in a candidate stem cell fraction in esophageal squamous cell carcinoma (ESCC), which shows significantly higher colony formation, enhanced tumor formation in mice, along with strong expression of epithelial mesenchymal transition-related genes...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28815448/-1-h-15-n-and-13-c-chemical-shift-assignments-of-the-c-terminal-domain-of-tradd
#4
Ning Zhang, Wensu Yuan, Jing-Song Fan, Zhi Lin
The tumor necrosis factor receptor-associated death domain protein, TRADD, is a multifunctional intracellular molecule participating in divergent signaling pathways, such as NF-κB and apoptosis. TRADD consists of two structurally distinct domains. Its N-terminal domain displays an α-β plaits fold while its C-terminal domain belongs to the death domain (DD) superfamily. TRADD DD is a central component in the tumor necrosis factor receptor 1 signaling. It interacts with other DD-containing proteins through homotypic interactions...
August 16, 2017: Biomolecular NMR Assignments
https://www.readbyqxmd.com/read/28809744/effect-of-vitamin-d-serum-levels-and-gc-gene-polymorphisms-in-liver-fibrosis-due-to-chronic-hepatitis-c
#5
Laura A Azevedo, Ursula Matte, Themis R Silveira, Jacqueline W Bonfanti, Juliana P Bruch, Mário R Álvares-da-Silva
INTRODUCTION AND AIM: Vitamin D has been associated with chronic liver diseases and low vitamin levels may contribute to progression of chronic hepatitis C. The aim of this study was to evaluate the influence of vitamin D serum levels and GC gene polymorphisms in the severity of liver fibrosis in patients with chronic hepatitis C genotype 1. MATERIAL AND METHODS: Cross-sectional study that enrolled 132 adult patients with chronic hepatitis C genotype 1 attended at the outpatient Clinic of Gastroenterology Division at Hospital de Clínicas de Porto Alegre...
August 8, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28801922/prophylaxis-with-enoxaparin-for-prevention-of-venous-thromboembolism-after-lung-transplantation-a-retrospective-study
#6
Berta Sáez-Giménez, Cristina Berastegui, Helena Sintes, Javier Perez, Ana Figueredo, Manuel López Meseguer, Víctor Monforte, Carlos Bravo, Amparo Santamaría, Maria Antonia Ramon, Susana Gómez, Antonio Roman
BACKGROUND: Venous thromboembolism (VTE) is a frequent complication after solid organ transplantation (SOT) and, specifically, after lung transplantation (LT). The objectives of this study were to evaluate prophylaxis with enoxaparin and to describe risk factors for VTE after LT. METHODS: We retrospectively reviewed the clinical records of 333 patients who underwent LT in our institution between 2009 and 2014. We compared 2 consecutive cohorts, one that received enoxaparin only during post-transplant hospital admissions and a second cohort that received 90-day extended prophylaxis with enoxaparin...
August 12, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28800076/human-dental-pulp-cells-differentiate-toward-neuronal-cells-and-promote-neuroregeneration-in-adult-organotypic-hippocampal-slices-in-vitro
#7
Li Xiao, Ryoji Ide, Chikako Saiki, Yasuo Kumazawa, Hisashi Okamura
The adult mammalian central nerve system has fundamental difficulties regarding effective neuroregeneration. The aim of this study is to investigate whether human dental pulp cells (DPCs) can promote neuroregeneration by (i) being differentiated toward neuronal cells and/or (ii) stimulating local neurogenesis in the adult hippocampus. Using immunostaining, we demonstrated that adult human dental pulp contains multipotent DPCs, including STRO-1, CD146 and P75-positive stem cells. DPC-formed spheroids were able to differentiate into neuronal, vascular, osteogenic and cartilaginous lineages under osteogenic induction...
August 11, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28790472/total-hip-arthroplasty-in-patients-of-post-polio-residual-paralysis-a-retrospective-case-series
#8
Francisco Borja Sobrón, Álvaro Martínez-Ayora, Manuel Cuervas-Mons, Tania Quevedo, Rafael Laguna, Javier Vaquero
BACKGROUND: Poliomyelitis is a viral, nervous system disease that affects both the upper and the lower extremities. The treatment of severe coxarthrosis in these patients with total hip arthroplasty (THA) has been widely questioned because of the high risk of subsequent complications. The aim of the present study was to describe both radiological and medium term clinical results in a series of patients with post polio residual paralysis that underwent THA. MATERIALS AND METHODS: We report a retrospective review of a series of 5 five patients diagnosed with severe coxarthrosis secondary to post polio residual paralysis who were operated between 2008 and 2012...
July 2017: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/28776905/expression-of-cytokine-and-extracellular-matrix-mrnas-in-fetal-hepatic-stellate-cells
#9
Keai Sinn Tan, Kasem Kulkeaw, Yoichi Nakanishi, Daisuke Sugiyama
In mouse fetal liver, hepatoblasts, sinusoidal endothelial cells and macrophages (or erythroblastic islands) promote differentiation and proliferation of hematopoietic cells through cell-cell interactions and secretion of cytokines and extracellular matrix factors. Until now, we have had little knowledge of the hematopoietic cytokines or extracellular matrix mRNAs expressed in hepatic stellate cells. Using p75 neurotrophin receptor (p75NTR) to mark this cell population, we sorted 12.5, 14.5 and 16.5 dpc hepatic stellate cells and analyzed expression of cytokines and extracellular matrix mRNAs...
August 4, 2017: Genes to Cells: Devoted to Molecular & Cellular Mechanisms
https://www.readbyqxmd.com/read/28774364/-penis-growth-and-development-in-children-and-adolescents-a-study-based-on-gamlss
#10
Qing-Jie Yi, Yan Zeng, Qing Zeng, Yi-Nan Wang, Feng Xiong
OBJECTIVE: To investigate penis development in children and adolescents aged 0-16 years, and to plot the percentile curve for penis development in different age groups. METHODS: A total of 3 024 normal male neonates, children, and adolescents aged 0-16 years in Chongqing, China were selected by simple random sampling and stratified cluster sampling. The length and diameter of the penis were measured for all subjects. A descriptive statistical analysis was used to investigate the data characteristics of the penis, and the GAMLSS fitting model was used to plot the percentile curves of P3, P10, P25, P50, P75, P90, and P97 and obtain percentile reference values...
August 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28768825/basolateral-delivery-of-the-type-i-transforming-growth-factor-beta-receptor-is-mediated-by-a-dominant-acting-cytoplasmic-motif
#11
Xueqian Yin, Jeong-Han Kang, Mahefatiana Andrianifahanana, Youli Wang, Mi-Yeon Jung, Danielle M Hernandez, Edward B Leof
Delivery of biomolecules to the correct subcellular locales is critical for proper physiological function. To that end, we have previously determined that the type I and II TGF-β receptors (TβRI and TβRII, respectively) localize to the basolateral domain in polarized epithelia. While TβRII targeting was shown to be regulated by sequences between amino acids 529-538, the analogous region(s) within TβRI is unknown. To address that question, sequential cytoplasmic TβRI truncations and point mutations identified a targeting motif between residues 158 to 163 (VxxEED) required for basolateral TβRI expression...
August 2, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28768292/assessing-inflammageing
#12
Ursula Müller-Werdan, Sebastian Nuding, Mario Ost
PURPOSE OF REVIEW: Immunosenescence has been scrutinized in detail, and evidence that inflammation and ageing are interrelated is consistent. Still, a gold standard for assessing the biological age of the immune function in an individual patient is lacking, so that immunosenescence is still not a quantifiable criterion in clinical decision-making processes. RECENT FINDINGS: This review highlights recent (partly ongoing) studies into biomarkers of inflammation to assess immunosenescence, including large-scale studies, and quotes expert opinion statements...
September 2017: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/28767729/protective-effect-of-clusterin-on-rod-photoreceptor-in-rat-model-of-retinitis-pigmentosa
#13
Andrew Vargas, Hwa Sun Kim, Erika Baral, Wan-Qing Yu, Cheryl Mae Craft, Eun-Jin Lee
Retinitis Pigmentosa (RP) begins with the death of rod photoreceptors and is slowly followed by a gradual loss of cones and a rearrangement of the remaining retinal neurons. Clusterin is a chaperone protein that protects cells and is involved in various pathophysiological stresses, including retinal degeneration. Using a well-established transgenic rat model of RP (rhodopsin S334ter), we investigated the effects of clusterin on rod photoreceptor survival. To investigate the role of clusterin in S334ter-line3 retinas, Voronoi analysis and immunohistochemistry were used to evaluate the geometry of rod distribution...
2017: PloS One
https://www.readbyqxmd.com/read/28765645/structure-of-the-c-terminal-domain-of-tradd-reveals-a-novel-fold-in-the-death-domain-superfamily
#14
Ning Zhang, Wensu Yuan, Jing-Song Fan, Zhi Lin
The TNFR1-associated death domain protein (TRADD) is an intracellular adaptor protein involved in various signaling pathways, such as antiapoptosis. Its C-terminal death domain (DD) is responsible for binding other DD-containing proteins including the p75 neurotrophin receptor (p75(NTR)). Here we present a solution structure of TRADD DD derived from high-resolution NMR spectroscopy. The TRADD DD comprises two super-secondary structures, an all-helix Greek key motif and a β-hairpin motif flanked by two α helices, which make it unique among all known DD structures...
August 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28762648/directed-differentiation-of-human-embryonic-stem-cells-to-neural-crest-stem-cells-functional-peripheral-neurons-and-corneal-keratocytes
#15
Qian Zhu, Mingming Li, Chuan Yan, Qiqi Lu, Shunhui Wei, Rong Gao, Mengfei Yu, Yu Zou, Gopu Sriram, Huei Jinn Tong, Walter Hunziker, Chaminda Jayampath Seneviratne, Zhiyuan Gong, Bjorn R Olsen, Tong Cao
Neural crest stem cells (NCSCs) are a transient and multipotent cell population giving rise to various cell types with clinical importance. Isolation of human NCSCs is extremely challenging that limits our knowledge about neural crest development and application. Here, we present a defined protocol to efficiently direct human embryonic stem cells (hESCs) to NCSCs and multiple neural crest lineages. A unique combination of small molecule inhibitors and growth factors was employed to generate NCSCs from hESCs through a neuroectoderm stage...
August 1, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/28761093/combined-serum-levels-of-multiple-proteins-in-tpa-bdnf-pathway-may-aid-the-diagnosis-of-five-mental-disorders
#16
Suzhen Chen, Haitang Jiang, Yang Liu, Zhenhua Hou, Yingying Yue, Yuqun Zhang, Fuying Zhao, Zhi Xu, Yinghui Li, Xiaodong Mou, Lei Li, Tianyu Wang, Jingjing Zhao, Chongyang Han, Yuxiu Sui, Ming Wang, Zhong Yang, Yan Lu, Yifeng Zhu, Jianhua Li, Xinhua Shen, Fei Sun, Qingsong Chen, Huanxin Chen, Yonggui Yuan
Mental disorders are severe, disabling conditions with unknown etiology and are commonly misdiagnosed when clinical symptomology criteria are solely used. Our previous work indicated that combination of serum levels of multiple proteins in tissue plasminogen activator (tPA)-brain-derived neurotrophic factor (BDNF) pathway improved accuracy of diagnosis of major depressive disorder (MDD). Here, we measured serum levels of tPA, plasminogen activator inhibitor-1 (PAI-1), BDNF, precursor-BDNF (proBDNF), tropomyosin-related kinase B (TrkB) and neurotrophin receptor p75 (p75NTR) in patients with paranoid schizophrenia (SZ, n = 34), MDD (n = 30), bipolar mania (BM, n = 30), bipolar depression (BD, n = 22), panic disorder (PD, n = 30), and healthy controls (HCs, n = 30) by Enzyme-linked immunosorbent assay kits...
July 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28759569/proposed-equations-and-reference-values-for-calculating-bone-health-in-children-and-adolescent-based-on-age-and-sex
#17
Rossana Gómez-Campos, Cynthia Lee Andruske, Miguel de Arruda, Camilo Urra Albornoz, Marco Cossio-Bolaños
BACKGROUND: The Dual Energy X-Ray Absorptiometry (DXA) is the gold standard for measuring BMD and bone mineral content (BMC). In general, DXA is ideal for pediatric use. However, the development of specific standards for particular geographic regions limits its use and application for certain socio-cultural contexts. Additionally, the anthropometry may be a low cost and easy to use alternative method in epidemiological contexts. The goal of our study was to develop regression equations for predicting bone health of children and adolescents based on anthropometric indicators to propose reference values based on age and sex...
2017: PloS One
https://www.readbyqxmd.com/read/28754126/modulation-of-chromatin-structure-by-the-fact-histone-chaperone-complex-regulates-hiv-1-integration
#18
Julien Matysiak, Paul Lesbats, Eric Mauro, Delphine Lapaillerie, Jean-William Dupuy, Angelica P Lopez, Mohamed Salah Benleulmi, Christina Calmels, Marie-Line Andreola, Marc Ruff, Manuel Llano, Olivier Delelis, Marc Lavigne, Vincent Parissi
BACKGROUND: Insertion of retroviral genome DNA occurs in the chromatin of the host cell. This step is modulated by chromatin structure as nucleosomes compaction was shown to prevent HIV-1 integration and chromatin remodeling has been reported to affect integration efficiency. LEDGF/p75-mediated targeting of the integration complex toward RNA polymerase II (polII) transcribed regions ensures optimal access to dynamic regions that are suitable for integration. Consequently, we have investigated the involvement of polII-associated factors in the regulation of HIV-1 integration...
July 28, 2017: Retrovirology
https://www.readbyqxmd.com/read/28753664/validation-of-a-novel-mho-microarray-for-a-comprehensive-characterisation-of-the-mycoplasma-hominis-action-in-hela-cell-infection
#19
Birgit Henrich, Freya Kretzmer, René Deenen, Karl Köhrer
Mycoplasma hominis is the second smallest facultative pathogen of the human urogenital tract. With less than 600 protein-encoding genes, it represents an ideal model organism for the study of host-pathogen interactions. For a comprehensive characterisation of the M. hominis action in infection a customized Mho microarray, which was based on two genome sequences (PG21 and LBD-4), was designed to analyze the dynamics of the mycoplasma transcriptome during infection and validated for M. hominis strain FBG. RNA preparation was evaluated and adapted to ensure the highest recovery of mycoplasmal mRNAs from in vitro HeLa cell infection assays...
2017: PloS One
https://www.readbyqxmd.com/read/28750567/impact-of-pharmacogenomics-upon-the-therapeutic-response-to-etanercept-in-psoriasis-and-psoriatic-arthritis
#20
Giuseppe Murdaca, Simone Negrini, Ottavia Magnani, Elena Penza, Marco Pellecchio, Francesco Puppo
TNF-α inhibitors have demonstrated efficacy both as monotherapy and in combination with disease-modifying anti-rheumatic drugs (DMARDs) in the treatment of chronic inflammatory immune-mediated diseases. Etanercept is a decoy receptor" for TNF-α and it is composed of two p75 TNF-α receptors fused to human IgG1. Areas covered: We discuss the potential role of pharmacogenetics in predicting the response to etanercept in patients with Ps and PsA. Expert opinion: Pharmacogenetics represents the new frontier for the discovery of potential genetic markers of biological response to TNF-α inhibitors...
July 28, 2017: Expert Opinion on Drug Safety
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