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https://www.readbyqxmd.com/read/29685994/feeder-free-differentiation-of-cells-exhibiting-characteristics-of-corneal-endothelium-from-human-induced-pluripotent-stem-cells
#1
Michael D Wagoner, Laura R Bohrer, Benjamin T Aldrich, Mark A Greiner, Robert F Mullins, Kristan S Worthington, Budd A Tucker, Luke A Wiley
The purpose of this study was to devise a strategy for the derivation of corneal endothelial cells (CEnCs) from adult fibroblast-derived induced pluripotent stem cells (iPSCs). IPSCs were generated from an adult human with normal ocular history via expression of OCT4 , SOX2 , KLF4 and c-MYC Neural crest cells (NCCs) were differentiated from iPSCs via addition of CHIR99021 and SB4315542. NCCs were driven toward a CEnC fate via addition of B27, PDGF-BB and DKK-2 to CEnC media. Differentiation of NCCs and CEnCs was evaluated via rt-PCR, morphological and immunocytochemical analysis...
April 23, 2018: Biology Open
https://www.readbyqxmd.com/read/29669804/subclinical-hypothyroidism-in-pregnant-rats-impaired-learning-and-memory-in-offspring-by-promoting-p75ntr-signaling
#2
Fan Zhang, Jian Chen, Xinyue Lin, Shiqiao Peng, Xiaohui Yu, Zhongyan Shan, Weiping Teng
OBJECTIVE: Maternal hypothyroidism during pregnancy can affect the neurodevelopment of their offspring. This study aimed to investigate the effects of maternal subclinical hypothyroidism (SCH) on spatial learning and memory, and its relationship with the apoptotic factors in cerebral cortex of the offspring. METHODS: Female adult Wistar rats were randomly divided into three groups (n=15 per group): control (CON) group, SCH group and overt hypothyroidism (OH) group...
April 18, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29660313/the-convergent-roles-of-cd271-p75-in-neural-crest-derived-melanoma-plasticity
#3
Jennifer C Kasemeier-Kulesa, Paul M Kulesa
The embryonic microenvironment is an important source of signals that promote multipotent cells to adopt a specific fate and direct cells along distinct migratory pathways. Yet, the ability of the embryonic microenvironment to retain multipotent progenitors or reprogram de-differentiated cells is less clear. Mistakes in cell differentiation or migration often result in developmental defects and tumorigenesis, including aggressive cancers that share many characteristics with embryonic progenitor cells. This is a striking feature of the vertebrate neural crest, a multipotent and highly migratory cell population first identified by Wilhelm His (His, 1868) with the potential to metamorphose into aggressive melanoma cancer...
April 13, 2018: Developmental Biology
https://www.readbyqxmd.com/read/29657832/predictive-value-of-serum-calprotectin-s100a8-a9-for-clinical-response-after-starting-or-tapering-anti-tnf-treatment-in-patients-with-rheumatoid-arthritis
#4
Lieke Tweehuysen, Nathan den Broeder, Noortje van Herwaarden, Leo A B Joosten, Peter L van Lent, Thomas Vogl, Frank H J van den Hoogen, Rogier M Thurlings, Alfons A den Broeder
Objectives: Calprotectin (S100A8/A9) has been correlated with disease activity in rheumatoid arthritis (RA). The aim of this study was to investigate the predictive value of serum calprotectin for clinical response after starting and tapering anti-tumour necrosis factor treatment in RA. Methods: Serum samples and clinical outcomes were derived from two longitudinal RA studies.At baseline (starting or tapering of adalimumab or etanercept), calprotectin levels were determined by ELISA...
2018: RMD Open
https://www.readbyqxmd.com/read/29650436/iodine-nutrition-status-and-prevalence-of-abnormal-tsh-levels-in-schoolchildren-aged-6-7-years-in-the-autonomous-community-of-the-basque-country
#5
Juan José Arrizabalaga, Mercedes Jalón, Mercedes Espada, Mercedes Cañas, José María Arena, Lluís Vila
INTRODUCTION: An epidemiological study conducted between 1988 and 1992 showed iodine deficiency and endemic goiter in the schoolchildren of the autonomous community of the Basque Country. OBJECTIVES: 1) To ascertain the iodine nutrition status of schoolchildren aged 6-7 years, and 2) to estimate the prevalence of abnormal TSH levels in capillary blood. POPULATION AND METHODS: The study was conducted on 497 schoolchildren selected by random sampling...
April 10, 2018: Endocrinología, Diabetes y Nutrición
https://www.readbyqxmd.com/read/29643634/tanezumab-therapy-targeting-nerve-growth-factor-in-pain-pathogenesis
#6
Mona K Patel, Alan D Kaye, Richard D Urman
In recent years, nerve growth factor (NGF) and the NGF receptor have become potential therapeutic targets in the treatment of acute and chronic pain states. NGF is a neurotrophin involved in regulating the function of sensory and sympathetic neurons during development. Numerous pain states have been linked to elevated levels of NGF and its role in increasing the perception of pain. Tanezumab, a recombinant humanized monoclonal antibody (IgG), was developed to target NGF, binding both circulating and local tissue NGF preventing interaction with the tropomyosin-related kinase-A and p75 receptors...
January 2018: Journal of Anaesthesiology, Clinical Pharmacology
https://www.readbyqxmd.com/read/29643084/factors-associated-with-treatment-delays-in-pediatric-refractory-convulsive-status-epilepticus
#7
I Sánchez Fernández, M Gaínza-Lein, N S Abend, A E Anderson, R Arya, J N Brenton, J L Carpenter, K E Chapman, J Clark, W D Gaillard, T A Glauser, J L Goldstein, H P Goodkin, A R Helseth, M C Jackson, K Kapur, Y-C Lai, T L McDonough, M A Mikati, A Nayak, K Peariso, J J Riviello, R C Tasker, D Tchapyjnikov, A A Topjian, M S Wainwright, A Wilfong, K Williams, T Loddenkemper
OBJECTIVE: To identify factors associated with treatment delays in pediatric patients with convulsive refractory status epilepticus (rSE). METHODS: This prospective, observational study was performed from June 2011 to March 2017 on pediatric patients (1 month to 21 years of age) with rSE. We evaluated potential factors associated with increased treatment delays in a Cox proportional hazards model. RESULTS: We studied 219 patients (53% males) with a median (25th-75th percentiles [p25 -p75 ]) age of 3...
April 11, 2018: Neurology
https://www.readbyqxmd.com/read/29626490/beyond-good-and-evil-a-putative-continuum-sorting-hypothesis-for-the-functional-role-of-probdnf-bdnf-propeptide-mbdnf-in-antidepressant-treatment
#8
REVIEW
Cassiano R A F Diniz, Plinio C Casarotto, Leonardo Resstel, R L Joca Sâmia
Depression and posttraumatic stress disorder are assumed to be maladaptive responses to stress and antidepressants are thought to counteract such responses by increasing BDNF (brain-derived neurotrophic factor) levels. BDNF acts through TrkB (tropomyosin-related receptor kinase B) and plays a central role in neuroplasticity. In contrast, both precursor proBDNF and BDNF propeptide (another metabolic product from proBDNF cleavage) have a high affinity to p75 receptor (p75R) and usually convey apoptosis and neuronal shrinkage...
April 4, 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29609077/compromise-of-cortical-prongf-maturation-causes-selective-retrograde-atrophy-in-cholinergic-nucleus-basalis-neurons
#9
Simon Allard, Marie L Jacobs, Sonia Do Carmo, A Claudio Cuello
The degeneration of basal forebrain cholinergic neurons (BFCNs) in Alzheimer's disease (AD) contributes to cognitive impairment. Nerve growth factor (NGF) secreted in the cerebral cortex is necessary for the phenotypic maintenance of BFCNs. AD is associated with disturbances in NGF metabolism, leading to reduced mature NGF levels and to an accumulation of its precursor, proNGF. We previously described that, in rats, this neurotrophic imbalance is sufficient to induce a loss of cortical cholinergic synapses...
March 9, 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29604364/the-p75-neurotrophin-receptor-might-mediate-sepsis-induced-synaptic-and-cognitive-impairments
#10
Muhuo Ji, Hong-Mei Yuan, Shan-Wu Feng, Jiangyan Xia, Jianjun Yang
Systemic inflammation induces cognitive impairment, yet the mechanism involved in this process is unclear. Neurotrophin receptor p75 (p75NTR ) signaling is a key pathological factor contributing to neurobehavioral abnormalities in many neurodegenerative diseases. However, the role of p75NTR signaling in the regulation of sepsis-induced cognitive impairment remains largely to be elucidated. In this study, systemic inflammation was induced by cecal ligation and puncture (CLP). Neurobehavioral performances were evaluated by open field, novel object recognition, and fear conditioning tests...
March 28, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29584618/role-of-prongf-p75-signaling-in-bladder-dysfunction-after-spinal-cord-injury
#11
Jae Cheon Ryu, Katharine Tooke, Susan E Malley, Anastasia Soulas, Tirzah Weiss, Nisha Ganesh, Nabila Saidi, Stephanie Daugherty, Uri Saragovi, Youko Ikeda, Irina Zabbarova, Anthony J Kanai, Mitsuharu Yoshiyama, H Francis Farhadi, William C de Groat, Margaret A Vizzard, Sung Ok Yoon
Loss of bladder control is a challenging outcome facing patients with spinal cord injury (SCI). We report that systemic blocking of pro-nerve growth factor (proNGF) signaling through p75 with a CNS-penetrating small-molecule p75 inhibitor resulted in significant improvement in bladder function after SCI in rodents. The usual hyperreflexia was attenuated with normal bladder pressure, and automatic micturition was acquired weeks earlier than in the controls. The improvement was associated with increased excitatory input to the spinal cord, in particular onto the tyrosine hydroxylase-positive fibers in the dorsal commissure...
March 26, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29580890/mifepristone-attenuates-depression-like-changes-induced-by-chronic-central-administration-of-interleukin-1%C3%AE-in-rats
#12
Yong-Ping Zhang, Hao-Yin Wang, Cai Zhang, Bai-Ping Liu, Zhi-Lan Peng, Yu-Yu Li, Cai Song
Increased proinflammatory cytokines, such as interleukin (IL)-1β, may play an important role in the etiology of depression because they cause the hypothalamic-pituitary-adrenal axis to release glucocorticoids (GC) and induce dysfunction of serotonin and norepinephrine neurotransmission. Sustained increase in GC may activate microglia to induce neuroinflammation, and suppress astrocytes to produce neurotrophins, which lead to neuronal apoptosis. Here, we tested the hypothesis that glucocorticoid receptor (GR) antagonist mifepristone (RU486) may attenuate IL-1β-induced depression-like behavior by regulating the neuroinflammation and neurotrophin functions of microglia and astrocytes...
March 23, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29578485/cysteine-rich-repeat-domains-2-and-4-are-amyloid-%C3%AE-binding-domains-of-neurotrophin-receptor-p75ntr-and-potential-targets-to-block-amyloid-%C3%AE-neurotoxicity
#13
Ye-Ran Wang, Jun Wang, Yu-Hui Liu, Gong-Ling Hu, Chang-Yue Gao, Yan-Jiang Wang, Xin-Fu Zhou, Fan Zeng
The p75 neurotrophin receptor (p75NTR) is an amyloid-β (Aβ) receptor that both mediates Aβ neurotoxicity and regulates Aβ production and deposition, thus playing an important role in the pathogenesis of Alzheimer's disease (AD). The extracellular domain of p75NTR (p75ECD), consisting of four cysteine-rich repeat domains (CRDs), was recently reported to be an endogenous anti-Aβ scavenger to block p75NTR-mediated neuronal death and neurite degeneration signaling of Aβ and pro-neurotrophins. Identification of the specific Aβ binding domains of p75NTR is crucial for illuminating their interactions and the etiology of AD...
March 23, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29578352/prospective-study-of-the-factors-associated-with-poor-tolerance-to-ambulatory-colonoscopy-under-conscious-sedation
#14
Israel Grilo-Bensusan, Pablo Herrera Martín, Remedios Jiménez-Mesa, Valle Aguado Álvarez
BACKGROUND: conscious sedation with benzodiazepines and opiates for colonoscopy is a widespread clinical practice. OBJECTIVE: to determine the patient's tolerance to colonoscopy and identify the factors associated with lower tolerance. METHODS: a prospective, single-center, descriptive study of patients undergoing ambulatory colonoscopy under conscious sedation. The pain was assessed using a visual analogue scale with a score of 0 to 100 and also qualitatively...
April 2018: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29578117/platelet-distribution-width-on-admission-predicts-in-stent-restenosis-in-patients-with-coronary-artery-disease-and-type-2-diabetes-mellitus-treated-with-percutaneous-coronary-intervention
#15
Cheng-Ping Hu, Yu Du, Yong Zhu, Chao Shi, Zheng Qin, Ying-Xin Zhao
Background: It is known that there is a definite association between platelet distribution width (PDW) and poor prognosis in patients with coronary artery disease (CAD) and type 2 diabetes mellitus (T2DM). However, there are no data available regarding the prognostic significance of PDW for in-stent restenosis (ISR) in patients with CAD and T2DM. We aimed to determine the value of PDW on admission that predicted ISR in patients with CAD and T2DM. Methods: Between January 2012 and December 2013, a total of 5232 consecutive patients diagnosed with CAD and T2DM undergoing percutaneous coronary intervention were admitted...
April 5, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29571609/assessment-of-parenteral-nutrition-prescription-in-canadian-acute-care-settings
#16
Daniela Adjemian, Bianca M Arendt, Johane P Allard
BACKGROUND: Parenteral nutrition (PN) prescription can be challenging in patients with complex conditions and has potential complications. OBJECTIVE: To assess PN prescription, monitoring, and PN-related complications in a Canadian acute care setting. METHODS: This was a prospective cohort study in which patients receiving PN were assessed by an auditor for nutritional status, PN-related prescription, monitoring, and complications. In addition, length of stay and mortality were recorded...
May 2018: Nutrition
https://www.readbyqxmd.com/read/29570595/influence-of-a-cluster-set-configuration-on-the-adaptations-to-short-term-power-training
#17
Antonio J Morales-Artacho, Paulino Padial, Amador García-Ramos, Alejandro Pérez-Castilla, Belén Feriche
Morales-Artacho, AJ, Padial, P, García-Ramos, A, Pérez-Castilla, A, and Feriche, B. Influence of a cluster set configuration on the adaptations to short-term power training. J Strength Cond Res 32(4): 930-937, 2018-This study investigated the effects of a traditional (TT) vs. cluster (CT) resistance training on the lower-body force, velocity, and power output. Nineteen males were allocated to a CT or a TT group and took part of a 3-week resistance training (2 weekly sessions). CT involved 6 sets of 3 × 2 repetitions (30 seconds rest every 2 repetitions and 4 minutes 30 seconds between sets)...
April 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29568737/assessment-of-a-single-decoupling-alchemical-approach-for-the-calculation-of-the-absolute-binding-free-energies-of-protein-peptide-complexes
#18
Denise Kilburg, Emilio Gallicchio
The computational modeling of peptide inhibitors to target protein-protein binding interfaces is growing in interest as these are often too large, too shallow, and too feature-less for conventional small molecule compounds. Here, we present a rare successful application of an alchemical binding free energy method for the calculation of converged absolute binding free energies of a series of protein-peptide complexes. Specifically, we report the binding free energies of a series of cyclic peptides derived from the LEDGF/p75 protein to the integrase receptor of the HIV1 virus...
2018: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/29545630/intravenous-c16-and-angiopoietin-1-improve-the-efficacy-of-placenta-derived-mesenchymal-stem-cell-therapy-for-eae
#19
Ke-Wei Tian, Yuan-Yuan Zhang, Hong Jiang, Shu Han
The placenta has emerged as an attractive source of mesenchymal stem cells (MSCs) because of the absence of ethical issues, non-invasive access, and abundant yield. However, inflammatory cell invasion into grafts negatively impacts the survival and efficacy of transplanted cells. Previous studies have shown that synthetic C16 peptide can competitively block the transmigration of leukocytes into the central nerve system, while angiopoietin-1 (Ang-1) can inhibit inflammation-induced blood vessel leakage and inflammatory cell infiltration in rats with experimental allergic encephalomyelitis (EAE)...
March 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29536265/adolescent-social-isolation-affects-schizophrenia-like-behavior-in-the-mam-e17-model-of-schizophrenia
#20
Ewelina Bator, Joachim Latusz, Urszula Głowacka, Aleksandra Radaszkiewicz, Kinga Mudlaff, Marzena Maćkowiak
Social isolation (SI) during adolescence may induce schizophrenia-like behavior. In the present study, we investigated whether adolescent SI might affect the development of schizophrenia-like behavior in the MAM-E17 neurodevelopmental model of schizophrenia. Rats were socially isolated for 10 days during adolescence (postnatal days (P) 30-40), followed by resocialization until late adolescence (P45-P48) or early adulthood (P70-P75); behavioral and neurochemical studies were performed at these ages. The behavioral studies analyzed locomotor activity, social interaction, recognition memory, and sensorimotor gating; GAD65 and GAD67 protein levels were measured in the prefrontal cortex...
March 13, 2018: Neurotoxicity Research
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