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Mark G Van Vledder, Vicky Kwakernaak, Tjebbe Hagenaars, Esther M M Van Lieshout, Michiel H J Verhofstad
BACKGROUND: High rates of pneumonia and death have been reported among elderly patients with rib fractures. This study aims to identify patterns of injury and risk factors for pneumonia and death in elderly patients with rib fractures. METHODS: A retrospective multicenter observational study was performed using data registered in the national trauma registry between 2008 and 2015 in the South West Netherlands Trauma region. Data regarding demographics, mechanism of injury, pulmonary and cardiovascular history, pattern of extra-thoracic and intrathoracic injuries, ICU admission, length of stay, and morbidity and mortality following admission were collected...
June 15, 2018: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
József Dudás, Wolfgang Dietl, Angela Romani, Susanne Reinold, Rudolf Glueckert, Anneliese Schrott-Fischer, Daniel Dejaco, Lejo Johnson Chacko, Raphaela Tuertscher, Volker Hans Schartinger, Herbert Riechelmann
Neurotrophins and their receptors might regulate cell survival in head and neck squamous cell carcinoma (HNSCC). mRNA expression of nerve growth factor (NGF) and protein synthesis of high (NTRK1) and low affinity neurotrophin (p75 neurotrophin receptor; NTR) receptors were investigated in normal oral mucosa and in HNSCC. HNSCC cell lines were treated with mitomycin C (MMC) and cell survival was investigated. Normal and malignant epithelial cells expressed NGF mRNA. NTRK1 was upregulated in 80% of HNSCC tissue, and 50% of HNSCC samples were p75NTR positive...
June 14, 2018: International Journal of Molecular Sciences
Magloire Nkosi Mpembi, Thierry Lukeba, Damien Mayemba, Victoria Kubuta Massamba, Thierry Matonda Ma Nzuzi, Symphorien Gokara, Etienne Vermeiren, Gilbert Mananga Lelo, Samuel Mampunza Ma Miezi
Context: in Africa's zones of conflict, recent studies report a high frequency of post-traumatic stress disorder (PTSD) particularly in community settings. Objective: This study aimed to contribute to a better management of patients experiencing violence subsequent to the Central African Republic socio-political conflict. Material and methods: We conducted a cross-sectional study of the medical records of patients receiving outpatient treatment in the Doctors Without Borders/Médecins Sans Frontières (France) Trauma Center, Bangui...
2018: Pan African Medical Journal
Susan Northfield, Jerome Wielens, Stephen Headey, Billy Williams-Noonan, Mark Mulcair, Martin Scanlon, Michael Parker, Philip Thompson, David Chalmers
The p75 splice variant of lens epithelium-derived growth factor (LEDGF) is a 75 kDa protein that is recruited by the human immunodeficiency virus (HIV) to tether the pre-integration complex to the host chromatin and promote integration of proviral DNA into the host genome. We have designed a series of small cyclic peptides that are structural mimics of the LEDGF binding domain, which interact with integrase as potential binding inhibitors. Here we present the X-ray crystal structures, NMR studies, SPR analysis and conformational studies of four cyclic peptides bound to the HIV-1 integrase core domain...
June 4, 2018: ChemMedChem
Ana María Mora, Leonel Córdoba, Juan Camilo Cano, David Hernandez-Bonilla, Larissa Pardo, Lourdes Schnaas, Donald R Smith, José A Menezes-Filho, Donna Mergler, Christian H Lindh, Brenda Eskenazi, Berna van Wendel de Joode
BACKGROUND: Although growing evidence suggests that early-life excess manganese (Mn) impairs neurodevelopment, data on the neurodevelopmental effects of mancozeb, a fungicide containing Mn, and its main metabolite ethylenethiourea (ETU) are limited. OBJECTIVE: We examined whether prenatal mancozeb exposure and excess Mn were associated with neurodevelopment in 355 1-y-old infants living near banana plantations with frequent aerial mancozeb spraying in Costa Rica...
May 2018: Environmental Health Perspectives
Irina V Zabbarova, Youko Ikeda, Evan J Carder, Peter Wipf, Amanda S Wolf-Johnston, Lori A Birder, Naoki Yoshimura, Samuel E Getchell, Khalifa Almansoori, Pradeep Tyagi, Christopher H Fry, Marcus J Drake, Anthony J Kanai
AIMS: To determine the role of p75 neurotrophin receptor (p75NTR ) and the therapeutic effect of the selective small molecule p75NTR modulator, LM11A-31, in spinal cord injury (SCI) induced lower urinary tract dysfunction (LTUD) using a mouse model. METHODS: Adult female T8 -T9 transected mice were gavaged daily with LM11A-31 (100 mg/kg) for up to 6 weeks, starting 1 day before, or 7 days following injury. Mice were evaluated in vivo using urine spot analysis, cystometrograms (CMGs), and external urethral sphincter (EUS) electromyograms (EMGs); and in vitro using histology, immunohistochemistry, and Western blot...
May 28, 2018: Neurourology and Urodynamics
Feiyu Gong, Zairong Wei, Wenhu Jin, Hai Li, Chengliang Deng, Bihua Wu, Kaiyu Nie
Objective: Inducing human amniotic membrane mesenchymal stem cells (hAMSCs) to Schwann cells-like cells (SCs-like cells) in vitro , and to evaluate the efficacy of transplantation of hAMSCs and SCs-like cells on nerves regeneration of the rat flaps. Methods: hAMSCs were isolated from placenta via two-step digestion and cultured by using trypsin and collagenase, then identified them by flow cytometry assay and immunofluorescence staining. The 3rd generation of hAMSCs cultured for 6 days were induced to SCs-like cells in vitro ; at 19 days after induction, the levels of S-100, p75, and glial fibrillary acidic protein (GFAP) were detected by immunofluorescence staining, Western blot, and real-time fluorescence quantitative PCR (qPCR)...
January 1, 2018: Chinese Journal of Reparative and Reconstructive Surgery
Alexey Surov, Hans Jonas Meyer, Karsten Winter, Cindy Richter, Anna-Kathrin Hoehn
Our purpose was to analyze associations between apparent diffusion coefficient (ADC) histogram analysis parameters and histopathologicalfeatures in head and neck squamous cell carcinoma (HNSCC). The study involved 32 patients with primary HNSCC. For every tumor, the following histogram analysis parameters were calculated: ADCmean, ADCmax, ADCmin , ADCmedian , ADCmode , P10, P25, P75, P90, kurtosis, skewness, and entropy. Furthermore, proliferation index KI 67, cell count, total and average nucleic areas were estimated...
May 4, 2018: Oncotarget
Nuria Suelves, Andrés Miguez, Saray López-Benito, Gerardo García-Díaz Barriga, Albert Giralt, Elena Alvarez-Periel, Juan Carlos Arévalo, Jordi Alberch, Silvia Ginés, Verónica Brito
Deficits in striatal brain-derived neurotrophic factor (BDNF) delivery and/or BDNF/tropomyosin receptor kinase B (TrkB) signaling may contribute to neurotrophic support reduction and selective early degeneration of striatal medium spiny neurons in Huntington's disease (HD). Furthermore, we and others have demonstrated that TrkB/p75NTR imbalance in vitro increases the vulnerability of striatal neurons to excitotoxic insults and induces corticostriatal synaptic alterations. We have now expanded these studies by analyzing the consequences of BDNF/TrkB/p75NTR imbalance in the onset of motor behavior and striatal neuropathology in HD mice...
May 27, 2018: Molecular Neurobiology
Pieter Pander, Inger N Sierevelt, Guy A B M Pecasse, Arthur van Noort
PURPOSE: Rotator cuff tears (RCT) are a common source of pain and disability of the shoulder and are frequently combined with pathology of the long head of the biceps tendon (LHBT). The aim of this study was to evaluate the long-term results (5-10 years) of arthroscopic debridement of the rotator cuff with or without tenotomy of the LHBT in patients with irreparable rotator cuff tears. METHODS: Patient files between January 2005 and December 2010 were retrospectively reviewed...
May 26, 2018: International Orthopaedics
F Edward Hickman, Emily M Stanley, Bruce D Carter
The p75 neurotrophin receptor (p75NTR) plays an integral role in patterning the sympathetic nervous system during development. Initially, p75NTR is expressed at low levels as sympathetic axons project toward their targets, which enables neurotrophin-3 (NT3) to activate TrkA receptors and promote growth. Upon reaching nerve growth factor (NGF) producing tissues, p75NTR is up regulated resulting in formation of TrkA-p75 complexes, which are high affinity binding sites selective for NGF, thereby blunting NT3 signaling...
May 22, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Alexey Surov, Gordian Hamerla, Hans Jonas Meyer, Karsten Winter, Stefan Schob, Eckhard Fiedler
PURPOSE: To analyze several histopathological features and their possible correlations with whole lesion histogram analysis derived from ADC maps in meningioma. MATERIALS AND METHODS: The retrospective study involved 36 patients with primary meningiomas. For every tumor, the following histogram analysis parameters of apparent diffusion coefficient (ADC) were calculated: ADCmean , ADCmax , ADCmin , ADCmedian , ADCmode , ADC percentiles: P10, P25, P75, P90, as well kurtosis, skewness, and entropy...
May 18, 2018: Magnetic Resonance Imaging
Sophie E Heethuis, Lucas Goense, Peter S N van Rossum, Alicia S Borggreve, Stella Mook, Francine E M Voncken, Annemarieke Bartels-Rutten, Berthe M P Aleman, Richard van Hillegersberg, Jelle P Ruurda, Gert J Meijer, Jan J W Lagendijk, Astrid L H M W van Lier
PURPOSE: To explore the potential benefit and complementary value of a multiparametric approach using diffusion-weighted (DW-) and dynamic contrast-enhanced (DCE-) magnetic resonance imaging (MRI) for prediction of response to neoadjuvant chemoradiotherapy (nCRT) in esophageal cancer. MATERIAL AND METHODS: Forty-five patients underwent both DW-MRI and DCE-MRI prior to nCRT (pre), during nCRT (week 2-3) (per) and after completion of nCRT, but prior to esophagectomy (post)...
May 21, 2018: Acta Oncologica
Sara R Westbrook, Minsu Kang, Luke K Sherrill, Dylan O'Hearn, Tanya Krishnamani, Joshua M Gulley
Rodent models have been especially useful for investigating adolescent ethanol exposure. However, there is a paucity of studies examining sex differences in behavioral intoxication from adolescent ethanol drinking. Here, we used an ethanol drinking model to investigate if adolescent rats of both sexes readily drink ethanol to measurable behavioral intoxication, indicated by increased impulsive action and motor incoordination. Beginning on postnatal day (P) 28, male and female Long-Evans rats were given 30-min access to a solution of sucrose (20%) or sweetened ethanol (20% sucrose +15% ethanol) every other day until P60 and once after 2 weeks of forced abstinence (on P75)...
May 21, 2018: Journal of the Experimental Analysis of Behavior
V Blazquez, A Rodríguez, A Sandiumenge, E Oliver, B Cancio, M Ibañez, G Miró, E Navas, M Badía, M D Bosque, M T Jurado, M López, M Llauradó, N Masnou, T Pont, M Bodí
OBJECTIVE: To determine factors related to limitations on life support within 48h of intensive care unit (ICU) admission. STUDY DESIGN: Prospective multicenter study. SETTING: Eleven ICUs. PATIENTS: All patients who died and/or had limitations on life support after ICU admission during a four-month period. VARIABLES: Patient characteristics, hospital characteristics, characteristics of limitations on life support...
May 7, 2018: Medicina Intensiva
Zhijun Lu, Jihui Sun, Yichun Xin, Ken Chen, Wen Ding, Yujia Wang
The aim of the present study was to confirm that sevoflurane induces memory impairment in the postnatal developing mouse brain and determine its mechanism of action. C57BL/6 mice 7 days old were randomly assigned into a 2.6% sevoflurane (n=68), a 1.3% sevoflurane (n=68) and a control (n=38) group. Blood gas analysis was performed to evaluate hypoxia and respiratory depression during anesthesia in 78 mice. Measurements for expression of caspase-3 by immunohistochemistry, cleavage of poly adenosine diphosphate-ribose polymerase (PARP) by western blotting, as well as levels of brain-derived neurotrophic factor (BDNF), tyrosine kinase receptor type 2 (Ntrk2), pro-BDNF, p75 neurotrophin receptor (p75NTR) and protein kinase B (PKB/Akt) by enzyme-linked immunosorbent assay were performed in the hippocampus of 12 mice from each group...
May 2018: Experimental and Therapeutic Medicine
Ying Zhao, Wenfei Liu, Ying Tian, ZhenLu Yang, Xiaofen Wang, Yunlei Zhang, Yuxia Tang, Shuang Zhao, Chunyan Wang, Ying Liu, Jing Sun, Zhaogang Teng, Shouju Wang, Guangming Lu
Non-small cell lung cancer (NSCLC) is difficult to cure since the high recurrence rate and the side effects of current treatments. It is urgent to develop a new treatment that is safer and more effective than current treatments against NSCLC. Herein, we constructed anti-EGFR peptide conjugated PEGylated triangular gold nanoplates (TGN-PEG-P75) as a targeting photothermal therapy (PTT) agent to treat NSCLC under the guidance of computed tomography (CT) and photoacoustic imaging (PAI). The surface of TGNs is successfully conjugated with a novel peptide P75 that has the specific affinity with epidermal growth factor receptor (EGFR)...
May 3, 2018: ACS Applied Materials & Interfaces
Joren R Ten Hove, Shailja C Shah, Seth R Shaffer, Charles N Bernstein, Daniel Castaneda, Carolina Palmela, Erik Mooiweer, Jordan Elman, Akash Kumar, Jason Glass, Jordan Axelrad, Thomas A Ullman, Jean-Frederic Colombel, Joana Torres, Adriaan A van Bodegraven, Frank Hoentjen, Jeroen M Jansen, Michiel E de Jong, Nofel Mahmmod, Andrea E van der Meulen-de Jong, Cyriel Y Ponsioen, Christine J van der Woude, Steven H Itzkowitz, Bas Oldenburg
OBJECTIVES: Surveillance colonoscopy is thought to prevent colorectal cancer (CRC) in patients with long-standing colonic IBD, but data regarding the frequency of surveillance and the findings thereof are lacking. Our aim was to determine whether consecutive negative surveillance colonoscopies adequately predict low neoplastic risk. DESIGN: A multicentre, multinational database of patients with long-standing IBD colitis without high-risk features and undergoing regular CRC surveillance was constructed...
May 2, 2018: Gut
Michael D Wagoner, Laura R Bohrer, Benjamin T Aldrich, Mark A Greiner, Robert F Mullins, Kristan S Worthington, Budd A Tucker, Luke A Wiley
The purpose of this study was to devise a strategy for the derivation of corneal endothelial cells (CEnCs) from adult fibroblast-derived induced pluripotent stem cells (iPSCs). IPSCs were generated from an adult human with normal ocular history via expression of OCT4 , SOX2 , KLF4 and c-MYC Neural crest cells (NCCs) were differentiated from iPSCs via addition of CHIR99021 and SB4315542. NCCs were driven toward a CEnC fate via addition of B27, PDGF-BB and DKK-2 to CEnC media. Differentiation of NCCs and CEnCs was evaluated via rt-PCR, morphological and immunocytochemical analysis...
May 8, 2018: Biology Open
Fan Zhang, Jian Chen, Xinyue Lin, Shiqiao Peng, Xiaohui Yu, Zhongyan Shan, Weiping Teng
OBJECTIVE: Maternal hypothyroidism during pregnancy can affect the neurodevelopment of their offspring. This study aimed to investigate the effects of maternal subclinical hypothyroidism (SCH) on spatial learning and memory, and its relationship with the apoptotic factors in cerebral cortex of the offspring. METHODS: Female adult Wistar rats were randomly divided into three groups ( n  = 15 per group): control (CON) group, SCH group and overt hypothyroidism (OH) group...
May 2018: Endocrine Connections
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