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https://www.readbyqxmd.com/read/28640217/suboptimal-iodine-concentration-in-breastmilk-and-inadequate-iodine-intake-among-lactating-women-in-norway
#1
Sigrun Henjum, Anne Marie Lilleengen, Inger Aakre, Anna Dudareva, Elin Lovise Folven Gjengedal, Helle Margrete Meltzer, Anne Lise Brantsæter
Breastfed infants depend on sufficient maternal iodine intake for optimal growth and neurological development. Despite this, few studies have assessed iodine concentrations in human milk and there is currently no published data on iodine status among lactating women in Norway. The aim of this study was to assess iodine concentrations in breast milk (BMIC) in lactating women and estimate iodine intake. Five Mother and Child Health Centres in Oslo were randomly selected during 2016, and 175 lactating women between 2nd and 28th weeks postpartum participated...
June 22, 2017: Nutrients
https://www.readbyqxmd.com/read/28636650/the-formation-of-lipid-droplets-favors-intracellular-mycobacterium-leprae-survival-in-sw-10-non-myelinating-schwann-cells
#2
Song-Hyo Jin, Sung-Kwan An, Seong-Beom Lee
Leprosy is a chronic infectious disease that is caused by the obligate intracellular pathogen Mycobacterium leprae (M.leprae), which is the leading cause of all non-traumatic peripheral neuropathies worldwide. Although both myelinating and non-myelinating Schwann cells are infected by M.leprae in patients with lepromatous leprosy, M.leprae preferentially invades the non-myelinating Schwann cells. However, the effect of M.leprae infection on non-myelinating Schwann cells has not been elucidated. Lipid droplets (LDs) are found in M...
June 21, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28633434/psip1-p75-promotes-tumorigenicity-in-breast-cancer-cells-by-promoting-the-transcription-of-cell-cycle-genes
#3
Deepak K Singh, Omid Gholamalamdari, Mahdieh Jadaliha, Xiao Ling Li, Yo-Chuen Lin, Yang Zhang, Shuomeng Guang, Seyedsasan Hashemikhabir, Saumya Tiwari, Yuelin J Zhu, Abid Khan, Anu Thomas, Arindam Chakraborty, Virgilia Macias, Andre K Balla, Rohit Bhargava, Sarath Chandra Janga, Jian Ma, Supriya G Prasanth, Ashish Lal, Kannanganattu V Prasanth
Breast cancer (BC) is a highly heterogeneous disease, both at the pathological and molecular level, and several chromatin-associated proteins play crucial roles in breast cancer initiation and progression. Here, we demonstrate the role of PSIP1 (PC4 and SF2 interacting protein)/p75 (LEDGF) in breast cancer progression. PSIP1/p75, previously identified as a chromatin-adaptor protein, is found to be upregulated in basal-like/triple negative breast cancer (TNBC) patient samples and cell lines. Immunohistochemistry in tissue arrays showed elevated levels of PSIP1 in metastatic invasive ductal carcinoma...
June 17, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28610923/l368f-v408f-double-mutant-of-ibd-of-ledgf-p75-retains-interaction-with-m178i-mutant-of-hiv-1-integrase
#4
Anu George, Nidhanapati K Raghavendra
Lens-epithelium-derived-growth factor (LEDGF/p75) is an essential host protein for integration of HIV-1 DNA into host genome. Earlier alanine scanning mutational analysis has revealed that residues I365, D366 and F406 in the integrase binding domain (IBD) of p75 are critical for interaction with HIV-1 integrase (IN), while K364, V408 have intermediate effect and residues N367, L368, R405, K407 show wild type binding with IN. To gain insight into contribution of side chains of L368 and V408 that are adjacent to critical residues I365 and F406, respectively, site directed mutation of these residues to Ile/Leu, Met and Phe has been performed and characterized in this study...
June 10, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28606078/how-to-select-a-proper-early-warning-threshold-to-detect-infectious-disease-outbreaks-based-on-the-china-infectious-disease-automated-alert-and-response-system-cidars
#5
Ruiping Wang, Yonggen Jiang, Engelgau Michael, Genming Zhao
BACKGROUND: China Centre for Diseases Control and Prevention (CDC) developed the China Infectious Disease Automated Alert and Response System (CIDARS) in 2005. The CIDARS was used to strengthen infectious disease surveillance and aid in the early warning of outbreak. The CIDARS has been integrated into the routine outbreak monitoring efforts of the CDC at all levels in China. Early warning threshold is crucial for outbreak detection in the CIDARS, but CDCs at all level are currently using thresholds recommended by the China CDC, and these recommended thresholds have recognized limitations...
June 12, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28596120/myelin-induced-inhibition-in-a-spiral-ganglion-organ-culture-approaching-a-natural-environment-in-vitro
#6
Benedikt Kramer, Anke Tropitzsch, Marcus Müller, Hubert Löwenheim
The performance of a cochlear implant depends on the defined interaction between afferent neurons of the spiral ganglion and the inserted electrode. Neurite outgrowth can be induced by neurotrophins such as brain-derived neurotrophic factor (BDNF) via tropomyosin kinase receptor B (TrkB). However, neurotrophin signaling through the p75 neurotrophin receptor (p75) inhibits neurite outgrowth in the presence of myelin. Organotypic cultures derived from postnatal (P3-5) mice were used to study myelin-induced inhibition in the cochlear spiral ganglion...
June 14, 2017: Neuroscience
https://www.readbyqxmd.com/read/28595321/mitochondrial-deficits-and-abnormal-mitochondrial-retrograde-axonal-transport-play-a-role-in-the-pathogenesis-of-mutant-hsp27-induced-charcot-marie-tooth-disease
#7
Bernadett Kalmar, Amy Innes, Klaus Wanisch, Alicia Koyen Kolaszynska, Amelie Pandraud, Gavin Kelly, Andrey Y Abramov, Mary M Reilly, Giampietro Schiavo, Linda Greensmith
Mutations in the small heat shock protein Hsp27, encoded by the HSPB1 gene, have been shown to cause Charcot Marie Tooth Disease type 2 (CMT-2) or distal hereditary motor neuropathy (dHMN). Protein aggregation and axonal transport deficits have been implicated in the disease. In this study, we conducted analysis of bidirectional movements of mitochondria in primary motor neuron axons expressing wild type and mutant Hsp27. We found significantly slower retrograde transport of mitochondria in Ser135Phe, Pro39Leu and Arg140Gly mutant Hsp27 expressing motor neurons than in wild type Hsp27 neurons, although anterograde movement velocities remained normal...
June 8, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28587660/recommendations-for-cerebrospinal-fluid-collection-for-the-analysis-by-elisa-of-neurogranin-trunc-p75-%C3%AE-synuclein-and-total-tau-in-combination-with-a%C3%AE-1-42-a%C3%AE-1-40
#8
Hugo Vanderstichele, Leentje Demeyer, Shorena Janelidze, Els Coart, Erik Stoops, Kimberley Mauroo, Victor Herbst, Cindy François, Oskar Hansson
BACKGROUND: The pathophysiology of neurodegeneration is complex. Its diagnosis requires an early identification of sequential changes in several hallmarks in the brains of affected subjects. The presence of brain pathology can be visualized in the cerebrospinal fluid (CSF) by protein profiling. It is clear that the field of Alzheimer's disease (AD) will benefit from an integration of algorithms including CSF concentrations of individual proteins, especially as an aid in clinical decision-making or to improve patient enrolment in clinical trials...
June 6, 2017: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/28582696/structural-basis-for-the-potent-inhibition-of-the-hiv-integrase-ledgf-p75-protein-protein-interaction
#9
Sergio R Ribone, Mario A Quevedo
Integrase (IN) constitutes one of the key enzymes involved in the lifecycle of the Human Immunodeficiency Virus (HIV), the etiological agent of AIDS. The biological role of IN strongly depends on the recognition and binding of cellular cofactors belonging to the infected host cell. Thus, the inhibition of the protein-protein interaction (PPI) between IN and cellular cofactors has been envisioned as a promising therapeutic target. In the present work we explore a structure-activity relationship for a set of 14 compounds reported as inhibitors of the PPI between IN and the lens epithelium-derived growth factor (LEDGF/p75)...
May 26, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28572757/muscle-contraction-regulates-bdnf-trkb-signaling-to-modulate-synaptic-function-through-presynaptic-cpkc%C3%AE-and-cpkc%C3%AE-i
#10
Erica Hurtado, Víctor Cilleros, Laura Nadal, Anna Simó, Teresa Obis, Neus Garcia, Manel M Santafé, Marta Tomàs, Katherine Halievski, Cynthia L Jordan, Maria A Lanuza, Josep Tomàs
The neurotrophin brain-derived neurotrophic factor (BDNF) acts via tropomyosin-related kinase B receptor (TrkB) to regulate synapse maintenance and function in the neuromuscular system. The potentiation of acetylcholine (ACh) release by BDNF requires TrkB phosphorylation and Protein Kinase C (PKC) activation. BDNF is secreted in an activity-dependent manner but it is not known if pre- and/or postsynaptic activities enhance BDNF expression in vivo at the neuromuscular junction (NMJ). Here, we investigated whether nerve and muscle cell activities regulate presynaptic conventional PKC (cPKCα and βI) via BDNF/TrkB signaling to modulate synaptic strength at the NMJ...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28567989/the-novel-synthetic-microneurotrophin-bnn27-protects-mature-oligodendrocytes-against-cuprizone-induced-death-through-the-ngf-receptor-trka
#11
Giulia Bonetto, Ioannis Charalampopoulos, Achille Gravanis, Domna Karagogeos
BNN27, a member of a chemical library of C17-spiroepoxy derivatives of the neurosteroid DHEA, has been shown to regulate neuronal survival through its selective interaction with NGF receptors (TrkA and p75(NTR) ), but its role on glial populations has not been studied. Here, we present evidence that BNN27 provides trophic action (rescue from apoptosis), in a TrkA-dependent manner, to mature oligodendrocytes when they are challenged with the cuprizone toxin in culture. BNN27 treatment also increases oligodendrocyte maturation and diminishes microglia activation in vitro...
August 2017: Glia
https://www.readbyqxmd.com/read/28565887/safety-and-efficacy-of-catheter-based-left-atrial-appendage-closure-in-patients-with-contraindications-for-long-term-anticoagulation
#12
Adrian Seidel, Abdul S Parwani, Florian Krackhardt, Martin Huemer, Philipp Attanasio, Wilhelm Haverkamp, Burkert Pieske, Leif-Hendrik Boldt
BACKGROUND: Percutaneous left atrial appendage closure (LAAC) and the role of post interventional anticoagulation often evokes controversy in daily practice. This study aimed to evaluate LAAC in patients with non-rheumatic atrial fibrillation, high thromboembolic risk and contraindications for long-term anticoagulation in a clinical scenario. METHODS AND RESULTS: Between 2010-2015, LAAC was attempted in 118 patients (47 women). Devices were successfully implanted in 95% (Watchman™ device n=97, St...
May 31, 2017: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/28560678/clinical-relevance-of-a-candidate-stem-cell-marker-p75-neurotrophin-receptor-p75ntr-expression-in-circulating-tumor-cells
#13
Tomoyuki Okumura, Tetsuji Yamaguchi, Toru Watanabe, Takuya Nagata, Yutaka Shimada
Despite advances in its diagnosis and multimodal therapies, the prognosis of esophageal squamous cell carcinoma (ESCC) patients remains poor, because of high incidences of metastasis . Recent reports suggested that circulating tumor stem cells (CTSCs), rather than circulating tumor cells (CTCs), were more accurate diagnostic marker for metastasis, because tumor stem cells or cancer stem cells (CSCs) are more responsible for metastasis through processes such as epithelial mesenchymal transition (EMT) and tumor initiation...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28559132/effect-of-reduced-glutathione-supplementation-in-semen-extender-on-tyrosine-phosphorylation-and-apoptosis-like-changes-in-frozen-thawed-hariana-bull-spermatozoa
#14
Nadeem Shah, Vijay Singh, Hanuman Prasad Yadav, Meena Verma, Dharmendra Singh Chauhan, Atul Saxena, Sarvajeet Yadav, Dilip Kumar Swain
To provide new insights into the mechanisms through which reduced glutathione (GSH) is able to protect spermatozoa, we tested the hypothesis that cryocapacitation and apoptosis like changes can contribute to the negative effect of freezing and thawing on bull spermatozoa, and that GSH prevent this damage. Having known protective effects of GSH in terms of a potent antioxidant, we evaluated capacitation, tyrosine phosphorylation and apoptosis like changes in bull spermatozoa after freezing and thawing in egg yolk tris glycerol extender containing (0...
May 20, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28554844/control-of-cancer-stem-cell-like-population-by-intracellular-target-identification-followed-by-the-treatment-with-peptide-sirna-complex
#15
Jin Sook Suh, Hyun Jung Lee, Hyun Nam, Buem Soo Jo, Dong Woo Lee, Ji-Hye Kim, Jue Yeon Lee, Chong Pyoung Chung, Gene Lee, Yoon Jeong Park
Cancer stem cells (CSCs) are a subpopulation of cancer cells and have been known to create cancer reoccurrence during cancer therapy due to their stem cell-like characteristics. However, exact target to control the CSC has not been fully established. Here, we enriched CD44(High) population of MDA-MB-231 cells by CD44 antibody as a CSC marker. By Phospho Antibody Array, CD44(High) population of MDA-MB-231 cells reveals Feline sarcoma-related tyrosine kinase (FER) protein was highly activated. When FER siRNA and low molecular weight protamine (LMWP) as cell penetrating peptides are applied to this population, cancer migration and colony forming ability are inhibited...
May 26, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28549740/skinfold-reference-curves-and-their-use-in-predicting-metabolic-syndrome-risk-in-children
#16
Alynne C R Andaki, Teresa M B de Quadros, Alex P Gordia, Jorge Mota, Adelson L A Tinôco, Edmar L Mendes
OBJECTIVES: To draw skinfold (SF) reference curves (subscapular, suprailiac, biceps, triceps) and to determine SF cutoff points for predicting the risk of metabolic syndrome (MetS) in children aged 6-10 years old. METHODS: This was a cross-sectional study with a random sample of 1480 children aged 6-10 years old, 52.2% females, from public and private schools located in the urban and rural areas of the municipality of Uberaba (MG). Anthropometry, blood pressure, and fasting blood samples were taken at school, following specific protocols...
May 23, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/28546430/crosstalk-between-the-h3k36me3-and-h4k16ac-histone-epigenetic-marks-in-dna-double-strand-break-repair
#17
Lin Li, Yinsheng Wang
Post-translational modifications of histone proteins regulate numerous cellular processes. Among these modifications, trimethylation of lysine 36 in histone H3 (H3K36me3) and acetylation of lysine 16 in histone H4 (H4K16ac) have important roles in transcriptional regulation and DNA damage response signaling. However, whether these two epigenetic histone marks are mechanistically linked remains unclear. Here, we discovered a new pathway through which H3K36me3 stimulates H4K16ac upon DNA double-strand break (DSB) induction in human cells...
May 25, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28545340/optimized-methods-for-rapidly-dissecting-spinal-cords-and-harvesting-spinal-motor-neurons-with-high-survival-and-purity-from-rats-at-different-embryonic-stages
#18
Shudong Chen, Ruimin Tian, Hui Li, Meihui Chen, Hu Zhang, Dingkun Lin
STUDY DESIGN: Experimental study, protocol optimization. OBJECTIVES: To investigate and compare the isolation of spinal motor neurons from embryonic rats at different embryonic stages, and develop optimized methods for rapidly dissecting spinal cords and harvesting spinal motor neurons with high survival and purity. SETTING: Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China. METHODS: Embryonic rats at different embryonic stages (12-18 days) were used to isolate spinal motor neurons...
May 25, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28541476/7-8-dihydroxyflavone-ameliorates-cognitive-and-motor-deficits-in-a-huntington-s-disease-mouse-model-through-specific-activation-of-the-plc%C3%AE-1-pathway
#19
Gerardo García-Díaz Barriga, Albert Giralt, Marta Anglada-Huguet, Nuria Gaja-Capdevila, Javier G Orlandi, Jordi Soriano, Josep-Maria Canals, Jordi Alberch
Huntington's disease (HD) is a fatal neurodegenerative disease with motor, cognitive and psychiatric impairment. Dysfunctions in HD models have been related to reduced levels of striatal brain-derived neurotrophic factor (BDNF) and imbalance between its receptors TrkB and p75(NTR). Thus, molecules with activity on the BDNF/TrkB/p75 system can have therapeutic potential. 7,8-Dihydroxyflavone (7,8-DHF) was described as a TrkB agonist in several models of neuro-degenerative diseases, however, its TrkB activation profile needs further investigation due to its pleiotropic properties and divergence from BDNF effect...
May 24, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28537420/nitration-and-glycation-turn-mature-ngf-into-a-toxic-factor-for-motor-neurons-a-role-for-p75-sup-ntr-sup-and-rage-signaling-in-als
#20
Mi Jin Kim, Marcelo R Vargas, Benjamin A Harlan, Kelby M Killoy, Lauren Ball, Susana Comte-Walters, Monika Gooz, Yasuhiko Yamamoto, Joseph S Beckman, Luis Barbeito, Mariana Pehar
Glycating stress can occur together with oxidative stress during neurodegeneration and contribute to the pathogenic mechanism. Nerve growth factor (NGF) accumulates in several neurodegenerative diseases. Besides promoting survival, NGF can paradoxically induce cell death by signaling through the p75 neurotrophin receptor (p75<sup>NTR</sup>). The ability of NGF to induce cell death is increased by nitration of its tyrosine residues under conditions associated with increased peroxynitrite formation...
May 24, 2017: Antioxidants & Redox Signaling
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