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https://www.readbyqxmd.com/read/28239705/chemical-communication-and-dynamics-of-droplet-emulsions-in-networks-of-belousov-zhabotinsky-micro-oscillators-produced-by-microfluidics
#1
Kristian Torbensen, Federico Rossi, Sandra Ristori, Ali Abou-Hassan
Chemical communication leading to synchronization and collective behaviour of dynamic elements, such as cell colonies, is a widespread phenomenon with biological, physical and chemical importance. Such synchronization between elements proceeds via chemical communication by emmision, interdiffusion and reception of specific messenger molecules. On a lab scale, these phenomena can be modeled by encapsulating an oscillating chemical reaction, which serves as a signal (information) sender/receiver element, inside microcompartments such as droplet emulsions, liposomes and polymersomes...
February 27, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28239692/high-throughput-screening-of-microchip-synthesized-genes-in-programmable-double-emulsion-droplets
#2
H F Chan, S Ma, J Tian, K W Leong
The rapid advances in synthetic biology and biotechnology are increasingly demanding high-throughput screening technology, such as screening of the functionalities of synthetic genes for optimization of protein expression. Compartmentalization of single cells in water-in-oil (W/O) emulsion droplets allows screening of a vast number of individualized assays, and recent advances in automated microfluidic devices further help realize the potential of droplet technology for high-throughput screening. However these single-emulsion droplets are incompatible with aqueous phase analysis and the inner droplet environment cannot easily communicate with the external phase...
February 27, 2017: Nanoscale
https://www.readbyqxmd.com/read/28238132/volumetric-bar-chart-chips-for-biosensing
#3
Yujun Song, Ying Li, Lidong Qin
The volumetric bar-chart chip (V-Chip) is a microfluidics-based, point-of-care (POC) device for the multiplexed and quantitative measurement of biomarkers. Volumetric readouts, based on the measurement of oxygen generated by a reaction between catalase and hydrogen peroxide, allow instant visual quantitation of target biomarkers and provide visualized bar charts without any assistance from instruments and without the need for data processing or graphics plotting. V-Chip shows potential capabilities in POC and personalized diagnostics; for instance, it can be utilized for making high-throughput, multiplexed, and quantitative measurements...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28238062/novel-microbial-photobioelectrochemical-cell-using-an-invasive-ultramicroelectrode-array-and-a-microfluidic-chamber
#4
Joon-Geun Ha, Young Seok Song, Sunghwan Jung, Soohwan Jang, Yong-Kweon Kim, Seoung Jai Bai, Jae-Hyoung Park, Seung-Ki Lee
OBJECTIVE: To fabricate a novel microbial photobioelectrochemical cell using silicon microfabrication techniques. RESULTS: High-density photosynthetic cells were immobilized in a microfluidic chamber, and ultra-microelectrodes in a microtip array were inserted into the cytosolic space of the cells to directly harvest photosynthetic electrons. In this way, the microbial photobioelectrochemical cell operated without the aid of electron mediators. Both short circuit current and open circuit voltage of the microbial photobioelectrochemical cell responded to light stimuli, and recorded as high as 250 pA and 45 mV, respectively...
February 25, 2017: Biotechnology Letters
https://www.readbyqxmd.com/read/28236212/probing-the-bi-directional-interaction-between-microglia-and-gliomas-in-a-tumor-microenvironment-on-a-microdevice
#5
Rui Gu, Xu Zhang, Ge Zhang, Tingting Tao, Haibo Yu, Lianqing Liu, Ying Dou, Aiping Li, Jianhua Qin
It has been proven that microglia are involved in both early and late stages of glioma progression and contribute substantially to the tumor mass of gliomas. Because no appropriate in vitro or in vivo investigative approach is available, the dynamic interaction between microglia and gliomas during tumor formation remains unclear. In this study, three types of microfluidic assay were developed to examine the outcomes of the dynamic interaction between microglia and gliomas. Co-migration assay and two-dimensional cell co-culture assay have been used to show that microglial BV-2 cells migrate toward C6 glioma cells and inhibit tumor growth during the early stage of tumorigenesis...
February 24, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28230980/chitosan-modified-filter-paper-for-nucleic-acid-extraction-and-in-situ-pcr-on-a-thermoplastic-microchip
#6
Wupeng Gan, Yin Gu, Junping Han, Caixia Li, Jing Sun, Peng Liu
Plastic microfluidic devices with embedded chitosan-modified Fusion 5 filter paper (unmodified one purchased from GE Healthcare) have been successfully developed for DNA extraction and concentration, utilizing two different mechanisms for DNA capture: the physical entanglement of long-chain DNA molecules with the fiber matrix of the filter paper and the electrostatic adsorption of DNA to the chitosan-modified filter fibers. This new method not only provided a high DNA extraction efficiency at a pH of 5 by synergistically combining these two capture mechanisms together, but also resisted the elution of DNA from filters at a pH >8 due to the entanglement of DNA with fibers...
February 23, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28230979/simple-expendable-3d-printed-microfluidic-systems-for-sample-preparation-of-petroleum
#7
Erica Megumi Kataoka, Rui Cesar Murer, Jandyson Machado Santos, Rogerio Mesquita de Carvalho, Marcos Nogueira Eberlin, Fabio Augusto, Ronei Jesus Poppi, Angelo Luiz Gobbi, Leandro Wang Hantao
In this study, we introduce a simple protocol to manufacture disposable, 3D-printed microfluidic systems for sample preparation of petroleum. Such platform is produced with a consumer-grade 3D-printer, using fused deposition modeling. Successful incorporation of solid-phase extraction (SPE) to microchip was ensured by facile 3D element integration using proposed approach. This 3D-printed μSPE device was applied to challenging matrices in oil & gas industry, such as crude oil and oil-brine emulsions. Case studies investigated important limitations of non-silicon and non-glass microchips, namely, resistance to nonpolar solvents and conservation of sample integrity...
February 23, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28227816/a-wide-range-and-high-sensitivity-four-channel-compact-electrochemical-biosensor-for-neurotransmitter-detection-on-a-microfluidic-platform
#8
Elnaz Ghodsevali, Hamza Landari, Mounir Boukadoum, Benoit Gosselin, Amine Miled, Elnaz Ghodsevali, Hamza Landari, Mounir Boukadoum, Benoit Gosselin, Amine Miled, Benoit Gosselin, Amine Miled, Elnaz Ghodsevali, Mounir Boukadoum, Hamza Landari
We present a four-channel, high-sensitivity and linearity electrochemical biosensor for neurotransmitter (NT) detection and measurement. Using a multi-channel microfluidic platform makes this biosensor capable of detecting NT-related currents going from nanoamperes to milliamperes, with a sensitivity of the order of picoamperes. Moreover, by using a fully differential potentiostat architecture, the biosensor offers a high common-mode rejection ratio (90 dB), making it appropriate for low-noise and high-sensitive applications...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227815/lab-on-chips-for-manipulation-of-small-scale-organisms-to-facilitate-imaging-of-neurons-and-organs
#9
Ramtin Ardeshiri, Pouya Rezai, Ramtin Ardeshiri, Pouya Rezai, Ramtin Ardeshiri, Pouya Rezai
Caenorhabditis elegans (C. elegans) and Drosophila melanogaster (D. melanogaster) are widely-used model organisms for neurological and cardiac studies due to their simple neuronal (302 neurons in C. elegans) and cardiac (simple tubular organ in D. melanogaster) systems. However, their small sizes and continuous mobility impede their precise and timely manipulation, hence, limiting the assays that can be done using conventional manual methods. This has resulted in a need for technologies that allow multidirectional manipulation of model organisms to enable studies on target neurons and organs throughout the body...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227794/a-numerical-and-experimental-study-of-acoustic-micromixing-in-3d-microchannels-for-lab-on-a-chip-devices
#10
Susana O Catarino, Vania C Pinto, Paulo J Sousa, Rui Lima, Joao M Miranda, Graca Minas, Susana O Catarino, Vania C Pinto, Paulo J Sousa, Rui Lima, Joao M Miranda, Graca Minas, Joao M Miranda, Paulo J Sousa, Susana O Catarino, Rui Lima, Vania C Pinto, Graca Minas
This paper reports a numerical and experimental study of acoustic streaming and micromixing in polydimethylsiloxane microchannels. The mixing between two fluids flowing in microchannels was evaluated through the following conditions: (1) using a 28 μm thick β-poly(vinylidene fluoride) (β-PVDF) as a piezoelectric transducer actuated with a 24 Vpp and 40 MHz sinusoidal voltage; (2) using different flow rates. The results suggest that the mixing length increases as the flow rate increases and that the acoustic streaming phenomenon leads to a reduction on the mixing length...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227150/integration-of-optical-and-electrochemical-sensors-on-a-microfluidic-platform-using-organic-optoelectronic-components-and-silver-nanowires
#11
Sujittra Poorahong, Florent Lefevre, Marie-Claude Perron, Philippe Juneau, Ricardo Izquierdo, Sujittra Poorahong, Florent Lefevre, Marie-Claude Perron, Philippe Juneau, Ricardo Izquierdo, Sujittra Poorahong, Ricardo Izquierdo, Florent Lefevre, Philippe Juneau, Marie-Claude Perron
Since the emergence of microfluidic platforms sensors integration has been a major challenge. With the advances in miniaturization of these platforms, there is a need for solutions to integrate various optical components in order to build sensors, which will offer different detection characteristics such as several emission and sensing wavelengths. Moreover, the integration of an electrochemical sensor including a transparent electrode that will be compatible with the optical sensor represents an additional challenge...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227149/automated-and-reconfigurable-platform-for-niosome-generation-based-on-a-microfluidic-architecture
#12
Frederic Tessier, Myriam Laprise-Pelletier, Eric Boilard, Marc-Andre Fortin, Amine Miled, Frederic Tessier, Myriam Laprise-Pelletier, Eric Boilard, Marc-Andre Fortin, Amine Miled, Marc-Andre Fortin, Eric Boilard, Amine Miled, Frederic Tessier, Myriam Laprise-Pelletier
Drug delivery at the nano-scale is becoming an important topic in nano and regenerative medicine as it can offer a very localized therapy. Therefore, niosomes are one of the most important vehicles to release drug at the nanoscale. In this paper, we present a new automated microsystem for niosome generation on-demand. Used niosome were based on a mixture of cholesterol and dicetyl phosphate with chloroform. Three compact micropumps are connected to a microfluidic substrate in order to generate 100 nm noisome vesicles...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227148/towards-a-multi-wavelength-spectroscopy-platform-for-blood-characterization-and-analysis
#13
Alireza Avakh Kisomi, Hamza Landari, Mounir Boukadoum, Amine Miled, Benoit Gosselin, Alireza Avakh Kisomi, Hamza Landari, Mounir Boukadoum, Amine Miled, Benoit Gosselin, Hamza Landari, Benoit Gosselin, Amine Miled, Mounir Boukadoum
Passing multiple light wavelengths through a blood sample makes it possible to investigate the presence and composition of cells, metabolytes and analytes such as blood cells, glucose, lactate and oxygen, providing valuable indications for diagnostic and health monitoring. In this paper, we present a test prototype of a multi-wavelength blood spectroscopy platform integrated with a microfluidic substrate to collect and convey blood samples through a series of micro-LEDs and a photo-detector. This spectroscopy platform is a proof of concept for a system that can collect absorbance and transmittance parameters of blood samples at several wavelengths within the visible and NIR spectrum, and transmit them wirelessly to a base station for real-time calculation and analysis...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227146/power-management-design-for-lab-on-chip-biosensors
#14
Xiaojian Yu, Kambiz Moez, I-Chyn Wey, Jie Chen, Xiaojian Yu, Kambiz Moez, I-Chyn Wey, Jie Chen, Kambiz Moez, Xiaojian Yu, I-Chyn Wey, Jie Chen
Over the past decades, we have witnessed the growth demands of portable lab-on-chip biosensors. These lab-on-chip devices are mostly powered by battery, and intelligent power management systems are required to provide supply voltage for different functional units on biosensors (e.g. a microfluidic control system might require higher voltage than the rest working units of biosensors). In this paper, a fully integrated multiple-stage voltage multiplier is proposed to provide high-voltage power needs. The proposed design was implemented with the IBM's 0...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226930/highly-sensitive-detection-of-human-cancer-antigens-by-an-immunogold-silver-assay-chip-coupled-with-a-polythiophene-based-optical-sensor
#15
Nuno M M Pires, Tao Dong, Nuno M M Pires, Tao Dong, Nuno M M Pires, Tao Dong
This work presents a novel method for protein or cancer antigen detection in clinical samples by an immunogold-silver assay microfluidic biochip coupled with a polythiophene-based organic photodetector. The method has showed a detection limit below 1ng/mL and the low cost and high sensitivity of both organic photodetector and immunogold-silver assay make this method amenable for realization in a portable handheld probe tip biosensor.
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226899/nanoporous-membrane-robustness-stability-in-small-form-factor-microfluidic-filtration-system
#16
Dean G Johnson, Sabrina Pan, Andrew Hayden, James L McGrath, Dean G Johnson, Sabrina Pan, Andrew Hayden, James L McGrath, Andrew Hayden, Sabrina Pan, Dean G Johnson, James L McGrath
The development of wearable hemodialysis (HD) devices that replace center-based HD holds the promise to improve both outcomes and quality-of-life for patients with end-stage-renal disease (ERD). A prerequisite for these devices is the development of highly efficient membranes that can achieve high toxin clearance in small footprints. The ultrathin nanoporous membrane material developed by our group is orders of magnitude more permeable than conventional HD membranes. We report on our progress making a prototype wearable dialysis unit...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226540/micro-tube-mass-production-device-for-microbial-culture
#17
K Fujimoto, M Ogawa, K Higashi, N Miki, K Fujimoto, M Ogawa, K Higashi, N Miki, K Higashi, K Fujimoto, M Ogawa, N Miki
This paper describes mass production system of micro-tubes for microbial culture in an open environment. Microbes are used in many fields, such as food, medicine, environmental and energy. We proposed a microbe culture system using hydrogel micro-tubes, which can protect the target microbes inside from competitive microbes outside of the tubes while allow oxygen and nutrition to diffuse through. The hydrogel micro-tubes can be produced by a microfluidic device, which can precisely control the flow and therefore, the tube geometry...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226539/directing-the-spatial-patterning-of-motor-neuron-differentiation-in-engineered-microenvironments
#18
Christopher J Demers, Greg Cox, Scott D Collins, Rosemary L Smith, Christopher J Demers, Greg Cox, Scott D Collins, Rosemary L Smith, Greg Cox, Christopher J Demers, Scott D Collins, Rosemary L Smith
Embryonic development of the spinal cord proceeds through a carefully orchestrated temporal and spatial sequence of chemical cues to provide precise patterning of adult cell types. Recreating this complex microenvironment in a standard cell culture dish is difficult, if not impossible. In this paper, a microfluidic device is used to recapitulate, in vitro, the graded patterning events which occur during early spinal cord development. The microdevice design is developed using COMSOL modeling, with which the spatiotemporal profiles of multiple, diffusible morphogens are simulated...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226538/sheathless-and-high-throughput-sorting-of-paramagnetic-microparticles-in-a-magneto-hydrodynamic-microfluidic-device
#19
Vikash Kumar, Pouya Rezai, Vikash Kumar, Pouya Rezai, Vikash Kumar, Pouya Rezai
Sorting of microorganisms and particles from a mixture is critical for numerous biotechnological and medical applications. Several sorting methods such as pinched flow fractionation (PFF), optical sorting, dielectrophoresis, acoustic separation, magnetophoresis and deterministic lateral displacement (DLD) have been reported in literature. But most of these methods lack ideal characteristics of a sorter such as ability to process at high throughput, simple design, non-complicated fabrication method, sheathless operation and high purity in separation...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226535/probing-the-micromechanics-of-the-fastest-growing-plant-cell-the-pollen-tube
#20
Naveen Shamsudhin, Huseyin Baris Atakan, Nino Laubli, Hannes Vogler, Chengzhi Hu, Abu Sebastian, Ueli Grossniklaus, Bradley J Nelson, Naveen Shamsudhin, Huseyin Baris Atakan, Nino Laubli, Hannes Vogler, Chengzhi Hu, Abu Sebastian, Ueli Grossniklaus, Bradley J Nelson, Hannes Vogler, Ueli Grossniklaus, Nino Laubli, Bradley J Nelson, Naveen Shamsudhin, Huseyin Baris Atakan, Abu Sebastian, Chengzhi Hu
The pollen tube is a fast growing cellular protrusion that plays a key role in the reproductive process of flowering plants. It serves as an important model for studying cellular morphogenesis, anisotropic growth mechanisms, and cellular signaling in the plant sciences. The anisotropic growth of pollen tubes is driven by a finely tuned control of the intracellular turgor pressure and the extensibility of the cell wall. To decipher this internal feedback loop and mathematically model the growth process, a quantitative understanding of the mechanical properties of the cell wall is crucial, in addition to biochemical investigations...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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