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Mariana Ioniță, Livia Elena Crică, Stefan Ioan Voicu, Sorina Dinescu, Florin Miculescu, Marieta Costache, Horia Iovu
Comparative evaluation of innovative combinations of three types of carbon nanomaterial (CNM) highlighted membranes with important potential for biomedical applications. Non-solvent induced phase separation coupled with ultrasound technique was used to generate membranes comprised of (i) cellulose acetate/ammonia functionalized carbon nanotubes (CA/CNT), (ii) cellulose acetate/ammonia functionalized graphene oxide (CA/GO), and (iii) cellulose acetate/CNT-GO. Structural, topographical and thermal features as well as water and ethanol permeation, bovine serum albumin (BSA) and haemoglobin (Hb) rejection were evaluated...
March 1, 2018: Carbohydrate Polymers
Jamal Chabbi, Oumayma Jennah, Nadia Katir, Mohamed Lahcini, Mosto Bousmina, Abdelkrim El Kadib
Temporal release of synergistic and/or complementary chemicals (e.g.: drugs) is recognized as extremely challenging because of their frequently intertwined kinetic delivery and presently, straightforward concepts enabling to circumvent this bottleneck are missing in the open literature. In this framework, we report herein on aldehyde-functionalized, transparent and flexible chitosan-montmorillonite hybrid films that act as a new generation of eco-friendly, controlled-chemical release bioplastics. These dynamically-assembled nanomaterials are designed by a ternary assembly from biowaste derived chitin biopolymer, aromatic aldehydes and layered clay nanoparticles...
March 1, 2018: Carbohydrate Polymers
Agnieszka Grzelak, Maria Wojewódzka, Sylwia Meczynska-Wielgosz, Mariusz Zuberek, Dominika Wojciechowska, Marcin Kruszewski
Damage to mitochondria and subsequent ROS leakage is a commonly accepted mechanism of nanoparticle toxicity. However, malfunction of mitochondria results in generation of superoxide anion radical (O2•-), which due to the relatively low chemical reactivity is rather unlikely to cause harmful effects triggered by nanoparticles. We show that treatment of HepG2 cells with silver nanoparticles (AgNPs) resulted in generation of H2O2 instead of O2•-, as measured by ROS specific mitochondrial probes. Moreover, addition of a selective iron chelator diminished AgNPs toxicity...
January 9, 2018: Redox Biology
Mingjun Huang, Kan Yue, Jiahao Huang, Chang Liu, Zhe Zhou, Jing Wang, Kan Wu, Wenpeng Shan, An-Chang Shi, Stephen Z D Cheng
This work reports the molecular design, synthesis, and systematic study on the bulk self-assembly behaviors of three series of polyhedral oligomeric silsesquioxanes (POSS)-based multi-headed giant surfactants XDPOSS-PSn (X = 2, 3 and 4), which are composed of two, three or four hydrophilic hydroxyl-group functionalized DPOSS cages attached via one junction point to a hydrophobic polystyrene (PS) chain. These series of hybrid polymeric amphiphiles with precisely defined chemical structure and controllable molecular architecture are synthesized by the sequential usage of "click" reactions...
January 19, 2018: ACS Nano
Jianting Zhang, Xiao Wang, Kun Zhou, Gang Chen, Qiangbin Wang
In this work, a typical cylinder-shaped tobacco mosaic virus coat protein (TMVCP) is employed as an anisotropic building block to assemble into triclinic and hexagonal close-packed (HCP) protein crystals by introducing cysteine residues at the 1 and 3 sites and four histidine residues at the C-terminal, respectively. The engineered functional groups of cysteine and histidine in the TMVCP and the self-assembly conditions determine the thermodynamics and kinetics in the self-assembly process for forming different crystal structures...
January 19, 2018: ACS Nano
Chava Angell, Mingxuan Kai, Sibai Xie, Xiangyi Dong, Yi Chen
Beside its genomic properties, DNA is also recognized as a novel material in the field of nanoengineering. The specific bonding of base pairs can be used to direct the assembly of highly structured materials with specific nanoscale features such as periodic 2D arrays, 3D nanostructures, assembly of nanomaterials, and DNA nanomachines. In recent years, a variety of DNA nanomachines are developed because of their many potential applications in biosensing, diagnostics, and therapeutic applications. In this review, the fuel-powered motors and secondary structure motors, whose working mechanisms are inspired or derived from natural phenomena and nanomachines, are discussed...
January 19, 2018: Advanced Healthcare Materials
Brittany A Weldon, William C Griffith, Tomomi Workman, David K Scoville, Terrance J Kavanagh, Elaine M Faustman
Engineered nanomaterials are currently under review for their potential toxicity; however, their use in consumer/commercial products has continued to outpace risk assessments. In vitro methods may be utilized as tools to improve the efficiency of risk assessment approaches. We propose a framework to compare relationships between previously published in vitro and in vivo toxicity assessments of cadmium-selenium containing quantum dots (QDs) using benchmark dose (BMD) and dosimetric assessment methods. Although data were limited this approach was useful for identifying sensitive assays and strains...
January 19, 2018: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
Shiwen Fan, Sheng Bi, Qikun Li, Qinglei Guo, Junshan Liu, Zhongliang Ouyang, Chengming Jiang, Jinhui Song
Mechanical properties of size-dependent nanowires are important in nano-electro-mechanical systems (NEMS), and have attracted much research interest. It is desperate to characterize the size effect of nanowires at atmosphere directly to broaden its practical application instead of in high vacuum situation as reported previously. In this study, we systematically studied the Young's modulus of vertical ZnO nanowires at atmosphere. The diameters range from 48nm to 287 nm, with resonance method by non-contact atomic force microscopy (AFM)...
January 19, 2018: Nanotechnology
Santosh Phuyal, Mayes Kasem, Oskar Knittelfelder, Animesh Sharma, Davi de Miranda Fonseca, Vaineta Vebraite, Sergey Shaposhnikov, Geir Slupphaug, Vidar Skaug, Shanbeh Zienolddiny
The effects of long-term chronic exposure of human lung cells to multi-walled carbon nanotubes (MWCNT) and their impact upon cellular proteins and lipids were investigated. Since the lung is the major target organ, an in vitro normal bronchial epithelial cell line model was used. Additionally, to better mimic exposure to manufactured nanomaterials at occupational settings, cells were continuously exposed to two non-toxic and low doses of a MWCNT for 13-weeks. MWCNT-treatment increased ROS levels in cells without increasing oxidative DNA damage and resulted in differential expression of multiple anti- and pro-apoptotic proteins...
January 19, 2018: Nanotoxicology
Sourav P Mukherjee, Olesja Bondarenko, Pekka Kohonen, Fernando T Andón, Táňa Brzicová, Isabel Gessner, Sanjay Mathur, Massimo Bottini, Paolo Calligari, Lorenzo Stella, Elena Kisin, Anna Shvedova, Reija Autio, Heli Salminen-Mankonen, Riitta Lahesmaa, Bengt Fadeel
Carbon-based nanomaterials including carbon nanotubes (CNTs) have been shown to trigger inflammation. However, how these materials are 'sensed' by immune cells is not known. Here we compared the effects of two carbon-based nanomaterials, single-walled CNTs (SWCNTs) and graphene oxide (GO), on primary human monocyte-derived macrophages. Genome-wide transcriptomics assessment was performed at sub-cytotoxic doses. Pathway analysis of the microarray data revealed pronounced effects on chemokine-encoding genes in macrophages exposed to SWCNTs, but not in response to GO, and these results were validated by multiplex array-based cytokine and chemokine profiling...
January 18, 2018: Scientific Reports
Haifang Liu, Zhaohui Li, Yuanqiang Sun, Xin Geng, Yalei Hu, Hongmin Meng, Jia Ge, Lingbo Qu
Carbon dots (CDs) have a wide range of applications in chemical, physical and biomedical research fields. We are particularly interested in the use of CDs as fluorescence nanomaterials for targeted tumor cell imaging. One of the important aspects of success is to enhance the fluorescence quantum yields (QY) of CDs as well as increase their targetability to tumor cells. However, most of the reported CDs are limited by relative low QY. In the current study, for the first time, one-step synthesis of highly luminescent CDs by using folic acid (FA) as single precursor was obtained in natural water through hydrothermal method...
January 18, 2018: Scientific Reports
Mubashar Rehman, Asadullah Madni, Thomas J Webster
Titanium-based materials do not fulfill all the requirements of orthopedic implants due to a mismatch in mechanical properties with bone which are prone to change during the course of bone growth. Biofunctional biomaterials are a new class of materials that show bioactivity and adaptability at any stage of bone growth. Areas covered: Different biofunctional biomaterials have evolved over time that can enhance calcium phosphate (CaP) precipitation, stimulate osteogenic differentiation, and can control osteoblast gene expression...
January 18, 2018: Expert Review of Medical Devices
Daxing Xiong, Danial Saadatmand, Sergey V Dmitriev
Anomalous (non-Fourier) heat transport is no longer just a theoretical issue since it has been observed experimentally in a number of low-dimensional nanomaterials, such as SiGe nanowires, carbon nanotubes, and others. To understand these anomalous behaviors, exploring the microscopic origin of normal (Fourier) heat transport is a fascinating theoretical topic. However, this issue has not yet been fully understood even for one-dimensional (1D) model chains, in spite of a great amount of thorough studies done to date...
October 2017: Physical Review. E
T Philippe
Phase transitions are known to present peculiarities in small systems that are related to depletion effects of the ambient phase. Mass conservation affects the conditions of thermodynamic equilibrium between a nucleus of the new phase and the matrix as compared with nucleation in infinite systems. This finite-size effect is known to delay the phase transition but can also impede nucleation in very small systems as it stabilizes the initial state, originally metastable in infinite systems. In this work, we investigate this superstabilization effect in the context of classical nucleation theory in multicomponent solutions and we derive an analytical expression for the system size below which nucleation becomes thermodynamically impossible...
September 2017: Physical Review. E
Pengfei Zhao, Navneet Soin, K Prashanthi, Jinkai Chen, Shurong Dong, Erping Zhou, Zhigang Zhu, Anand Arcot Narasimulu, Carlo D Montemagno, Liyang Yu, Jikui Luo
Electrospinning is a simple, versatile technique for fabricating fibrous nanomaterials with the desirable features of extremely high porosities and large surface areas. Using emulsion electrospinning, polytetrafluoroethylene/polyethene oxide (PTFE/PEO) membranes were fabricated followed by a sintering process to obtain pure PTFE fibrous membranes, which were further utilised against a polyamide 6 (PA6) membrane for vertical contact-mode triboelectric nanogenerators (TENGs). Electrostatic force microscopy (EFM) measurements of the sintered electrospun PTFE membranes revealed the presence of both positive and negative surface charges owing to the transfer of positive charge from PEO which further corroborated by FTIR measurements...
January 18, 2018: ACS Applied Materials & Interfaces
Sabrina Simoncelli, Yi Li, Emiliano Cortes, Stefan A Maier
Self-assembly processes allow designing and creating complex nanostructures using molecules as building blocks and surfaces as scaffolds. This autonomous driven construction is possible due to a complex thermodynamic balance of molecule-surface interactions. As such, nanoscale guidance and control over this process is hard to achieve. Here we use the highly localized light-to-chemical-energy conversion of plasmonic materials to spatially cleave Au-S bonds on pre-determined locations within a single nanoparticle, enabling a high degree of control over this archetypal system for molecular self-assembly...
January 18, 2018: ACS Nano
Margarida Castro, Verónica Nogueira, Isabel Lopes, Maria N Vieira, Teresa Rocha-Santos, Ruth Pereira
This study aimed to explore the efficiency of two adsorbents, cork granules with different granulometry and titanium dioxide nanomaterial, in the removal of chemical oxygen demand (COD), colour and toxicity from a textile effluent. The adsorption assays with cork were unsatisfactory in the removal of chemical parameters however they eliminated the acute toxicity of the raw effluent to Daphnia magna. The assay with TiO2 NM did not prove to be efficient in the removal of colour and COD even after 240 min of contact; nevertheless it also reduced the raw effluent toxicity...
January 18, 2018: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
Lingbiao Meng, Yingjuan Zhang, Jicheng Zhang, Weidong Wu
Two-dimensional (2D) materials with strictly planar hyper-coordinated motifs are of great importance in fundamental science and potential applications but extremely rare. Here we theoretically design a novel 2D IIB-VIA inorganic system, namely Zn3O2 monolayer, by comprehensive first-principles computations. This Zn3O2 monolayer is composed from highly symmetrical tri-coordinated oxygen and tetra-coordinated zinc, featuring planar and peculiar triangle and pentangle combined bonded network. The newly predicted Zn3O2 monolayer possesses excellent dynamic and thermal stabilities and is also the lowest-energy structure of its 2D space indicated by particle swarm search, supporting its experimentally synthetic viability...
January 18, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
Andrew B Holmes, Frank X Gu
The study of the environmental fate of nanoscale TiO2 (n-TiO2) is a major recent research focus which requires a rapid and accurate on-site concentration determination method. Inductively coupled plasma mass spectroscopy (ICP-MS) has been the most widely used method for determining the concentration of n-TiO2 in environmental samples; however, poses many challenges, such as hazardous hydrofluoric acid pre-treatment and clear limitations in mobile on-site measurement and monitoring. This study demonstrates that industrial wastewater containing natural organic matter (NOM) can present a major challenge to the analysis of n-TiO2 by ICP-MS, and introduces a spectrophotometry technique that can be used as an alternative...
January 18, 2018: Environmental Technology
Wenqing Li, Liping Sun, Yiqiu Xia, Si-Jie Hao, Gong Cheng, Zhigang Wang, Yuan Wan, Chuandong Zhu, Hongzhang He, Si-Yang Zheng
Endo/lysosome escape is a major challenge in nanoparticles-based protein delivery for cancer therapy. To enhance endo/lysosomal escape and increase the efficacy of proteins delivery, current strategies mainly focuses on destroying endo/lysosomes by employing modified nanoparticles, such as pH-sensitive polyplexes, cell-penetrating peptides, and photosensitive molecules. Herein, we hypothesize that pre-treatment with empty nanocarriers might make endo/lysosomes occupied and affect the endo/lysosomal escape of subsequent protein delivery by nanocarriers...
January 18, 2018: ACS Applied Materials & Interfaces
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