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"Functional medicine"

Robert L Schmidt, Jonathan LoPresti, Michael T McDermott, Suzanna M Zick, Joely A Straseski
BACKGROUND: Clinical laboratories are under pressure to increase value by improving test utilization. The clinical utility of reverse triiodothyronine (rT3) is controversial. We conducted a study to identify order patterns that might suggest inappropriate utilization of reverse triiodothyronine. METHODS: We reviewed all orders for thyroid tests placed over a period of one year at a national reference laboratory. We analyzed order patterns by client (hospital) and by provider...
May 14, 2018: Thyroid: Official Journal of the American Thyroid Association
Xin Xiang, Lin Wu, Lining Mao, Yiming Liu
Azadirachta indica has previously been demonstrated to act as a multi‑functional medicinal plant for >2,000 years in India, and its neighboring countries. Currently, it is considered a natural resource with great value used in industrial product development and as a medicine for various types of diseases. The present study investigated the neuroprotective effects of Azadirachta indica which improved functional recovery in the 6‑hydroxydopamine induced rat Parkinson's disease (PD) model. Catalase, glutathione‑peroxidase, tumor necrosis factor‑α, interleukin (IL)‑1β, IL‑6, nuclear factor (NF)‑κB p65, inducible nitric oxide synthase (iNOS) and AChE activity levels were analyzed via ELISA...
March 28, 2018: Molecular Medicine Reports
Alice C Richer
Background: The U.S. military has seen dramatic increases in traumatic brain injuries (TBIs) among military personnel due to the nature of modern-day conflicts. Conventional TBI treatment for secondary brain injuries has suboptimal success rates, and patients, families, and healthcare professionals are increasingly turning to alternative medicine treatments. Objective: Effective treatments for the secondary injury cascades that occur after an initial brain trauma are unclear at this time. The goal of successful treatment options for secondary TBI injuries is to reduce oxidative stress, excitotoxicity, and inflammation while supporting mitochondrial functions and repair of membranes, synapses, and axons...
August 1, 2017: Medical Acupuncture
Kate Lawrence, Jeannette Hyde
Manipulating gut bacteria in the microbiome, through the use of probiotics and prebiotics, has been found to have an influence on both physical and emotional wellbeing. This study uses a dietary manipulation 'The Gut Makeover' designed to elicit positive changes to the gut bacteria within the microbiome. 21 healthy participants undertook 'The Gut Makeover' for a four week period. Weight and various aspects of health were assessed pre and post intervention using the Functional Medicine Medical Symptoms Questionnaire (MSQ)...
2017: PloS One
Jeffrey Bland
In the functional medicine model, the word function is aligned with the evolving understanding that disease is an endpoint and function is a process. Function can move both forward and backward. The vector of change in function through time is, in part, determined by the unique interaction of an individual's genome with their environment, diet, and lifestyle. The functional medicine model for health care is concerned less with what we call the dysfunction or disease , and more about the dynamic processes that resulted in the person's dysfunction...
February 2017: Integrative Medicine
Joseph Pizzorno
Most of the commonly prescribed conventional drugs treat only symptoms, not the underlying causes of a patient's disease. This logically leads to a perception that much of modern medicine is about management of chronic disease and prevention of more serious sequelae-not actual cures. However, most health care professionals are attracted to medicine with the mission of curing patients leading to the cognitive discord that eventually leads them to integrative/functional medicine. Though use of the term cure has been actively discouraged except in limited types of cases, perhaps true health care reform needs to reclaim this term and concept...
October 2016: Integrative Medicine
Gregory Plotnikoff, Melissa Barber
INTRODUCTION: Single-disorder or single-organ-system clinical practice guidelines are often of limited usefulness in guiding effective management of patients with chronic multidimensional signs and symptoms. The presence of multiple long-standing medical problems in a given patient despite intensive medical effort suggests that addressing systemic core imbalances could complement more narrowly focused approaches. CASE PRESENTATION: A 72-year-old man experiencing longstanding depression, fatigue, irritable bowel syndrome, and chronic pain in the context of additional refractory illnesses was assessed and treated, guided by a system-oriented approach to underlying core imbalances termed functional medicine...
2016: Permanente Journal
Patrick Hanaway
No abstract text is available yet for this article.
2016: Permanente Journal
Jeffrey Bland
The evidence is strong: Protection and restoration of the intestinal firewall is of primary importance in many patients suffering from a wide range of chronic diseases. The functional medicine approach to evaluation and treatment of problems associated with compromised integrity of the intestinal firewall represents a successful application of the systems biology approach to the management of chronic disease.
August 2016: Integrative Medicine
John Weeks
No abstract text is available yet for this article.
April 2016: Integrative Medicine
Susanne M Cutshall, Larry R Bergstrom, Daniel J Kalish
Fatigue, stress, and digestive disorders are common among adults, especially women. We conducted a 28-week pilot study to assess the efficacy of a functional medicine approach to improving stress, energy, fatigue, digestive issues, and quality of life in middle-aged women. Findings showed significant improvements in many stress, fatigue, and quality-of-life measures. The treatment program increased mean salivary dehydroepiandrosterone levels and the cortisol-dehydroepiandrosterone ratio. Stool sample analyses suggested that these treatments reduced Helicobacter pylori infections...
May 2016: Complementary Therapies in Clinical Practice
Elliot T Taxman, Erin D Conlon, Alex Speers, Kristin L Dismuke, Tonya S Heyman, Thomas L Taxman
More than one-half of all cancer patients use some combination of conventional and complementary medicine, but exactly how this is done and what the outcomes include are poorly understood. This case study reports the successful treatment of metastatic invasive ductal breast carcinoma by 2 physician groups with treatments that combined conventional chemotherapy with nutritional support guided by nutritional and digestive laboratory testing. The goal of minimizing side effects and enhancing outcomes was achieved in this patient who did not receive radiation therapy and is almost 3 y posttreatment with no evidence of recurrence...
March 2016: Integrative Medicine
Robert H Lerman, Jyh-Lurn Chang, Veera Konda, Anuradha Desai, Michael B Montalto
CONTEXT: Tetrahydro iso-α acids (THIAAs), derived from Humulus lupulus (hops), have demonstrated anti-inflammatory effects in vitro and in an animal model of rheumatoid arthritis (RA). Undenatured type 2 collagen has been found to be effective in clinical studies in RA and osteoarthritis (OA). OBJECTIVE: The study intended to evaluate the efficacy and safety of a proprietary tablet containing 150 mg of n-enriched THIAA (nTHIAA) and 10 mg of undenatured type 2 collagen (UC-II) (containing 25% UC-II) in patients with arthritis...
October 2015: Integrative Medicine
Jeffrey Bland
No abstract text is available yet for this article.
October 2015: Integrative Medicine
Peter J Muran, Sandra Y Muran, Cheryl L Beseler, Ercole L Cavalieri, Eleanor G Rogan, Muhammad Zahid
BACKGROUND/OBJECTIVE: A functional medicine approach to reduce breast cancer risk is preferable to early detection and treatment in maintaining breast health. Estrogens are implicated in breast cancer initiation through conversion to metabolites that react with DNA to form specific adducts associated with the development of breast cancer. The purpose of this study was to determine the ability of a defined clinical intervention, the AVERTi-Healthy Breast Program (AHBP), to reduce breast cancer risk conditions likely to develop into breast disease...
June 2015: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
Åsa Gransjön Craftman, Margareta Westerbotn, Eva von Strauss, Pernilla Hillerås, Lena Marmstål Hammar
BACKGROUND: People living at home who lack ability to manage their medicine are entitled to assistance to improve adherence provided by a home care assistant employed by social care. AIM: The aim was to describe how older people with chronic diseases, living at home, experience the use and assistance of administration of medicines in the context of social care. DESIGN: A qualitative descriptive study. METHODS: Ten participants (age 65+) living at home were interviewed in the participants' own homes...
December 2015: Scandinavian Journal of Caring Sciences
Walter Alexander
Many hypertension patients want to learn about ways to reduce reliance on pharmaceuticals, says functional medicine practitioner Mark Houston, who believes it is often possible to reduce or eliminate reliance on drugs using nutrition and nutraceuticals.
April 2014: P & T: a Peer-reviewed Journal for Formulary Management
Yu-Yu Kao, Tien-Fu Chuang, Shiou-Huei Chao, Jo-Hsuan Yang, Yu-Chuan Lin, Hui-Yu Huang
Pracparatum mungo (Lu-Do Huang) is a traditional Chinese functional medicine made from the natural fermentation of mung bean (Lǜ Dòu) mixed with other Chinese medicines. It has been recognized as having liver protecting and detoxifying effects. As mung beans have been verified to possess anti-inflammatory, antioxidant, antipyretic, and whitening actions, the present research utilized the in vitro, ex vivo, and in vivo experimental models to investigate the antioxidant and melanin inhibiting effects of P. mungo on the skin...
July 2013: Journal of Traditional and Complementary Medicine
Bayarmaa Birasuren, Hye Lim Oh, Cho Rong Kim, Na Yeon Kim, Hye Lyun Jeon, Mee Ree Kim
Ribes diacanthum Pall (RDP) is a member of the Saxifragaceae family. The plant is traditionally used in Mongolia for the treatment of various ailments associated with kidney and bladder's diseases, cystitis, kidney stone, and edema. This study was aimed to investigate antioxidant activities of different solvent extracts of whole Pall plants, based on ferric-reducing antioxidant potential (FRAP), 2,2'-azinobis(3-ethybenzothiazoline-6-sulfonic acid) (ABTS· +) radical scavenging activity, 1,1-diphenyl-2-picrydrazyl (DPPH·), and hydroxyl (·OH) radical scavenging activities...
December 2012: Preventive Nutrition and Food Science
Joseph E Pizzorno
As 21st century health care moves from a disease-based approach to a more patient-centric system that can address biochemical individuality to improve health and function, clinical decision making becomes more complex. Accentuating the problem is the lack of a clear standard for this more complex functional medicine approach. While there is relatively broad agreement in Western medicine for what constitutes competent assessment of disease and identification of related treatment approaches, the complex functional medicine model posits multiple and individualized diagnostic and therapeutic approaches, most or many of which have reasonable underlying science and principles, but which have not been rigorously tested in a research or clinical setting...
September 2012: Global Advances in Health and Medicine: Improving Healthcare Outcomes Worldwide
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