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https://www.readbyqxmd.com/read/29453855/nerve-reinnervation-and-itch-behaviour-in-a-rat-burn-wound-model
#1
Tiam M Saffari, Barthold N Schüttenhelm, Johan W van Neck, Jan C Holstege
In this study, we investigated whether post-burn itch in rats, after a full thickness burn, is correlated to the nervous reinnervation of the burn wound area. For this purpose, we determined scratching duration (expressed as sec/hr) at 24 hours, 2, 4, 8 and 12 weeks post-burn and combined this with immunohistochemistry for protein gene product 9.5 (PGP9.5) to identify all nerve fibers, calcitonin gene related peptide (CGRP) to identify peptidergic fibers, tyrosine hydroxylase (TH) for sympathetic fibers and growth-associated protein 43 (GAP-43) for regrowing fibers...
February 17, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29453213/the-cat-did-it-erythema-nodosum-and-additional-atypical-presentations-of-bartonella-henselae-infection-in-immunocompetent-hosts
#2
Ami Schattner, Livnat Uliel, Ina Dubin
A healthy patient presented with painful skin lesions on the anterior surface of her legs. Erythema nodosum was diagnosed but all the usual causes were ruled out. The finding of bilateral enlarged axillary lymph nodes with necrosis and granulomas led to the diagnosis of Bartonella infection, an unusual cause of erythema nodosum. Imaging also revealed splenomegaly and small para-aortic lymph nodes. Up to one quarter of the patients with cat-scratch disease present atypically, a considerably higher prevalence than previously reported...
February 16, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29451997/poly-lactic-co-glycolic-acid-as-a-slow-release-drug-carrying-matrix-for-methotrexate-coated-onto-intraocular-lenses-to-conquer-posterior-capsule-opacification
#3
Stefan A Kassumeh, Christian M Wertheimer, Annabel von Studnitz, Anna Hillenmayer, Claudia Priglinger, Armin Wolf, Wolfgang J Mayer, Daniel Teupser, Lesca M Holdt, Siegfried G Priglinger, Kirsten H Eibl-Lindner
PURPOSE: Posterior capsule opacification (PCO) still represents the main long-term complication of cataract surgery. Research into pharmacologic PCO prophylaxis is extensive. One promising candidate drug is methotrexate (MTX). Our aim is to determine the in vitro feasibility of MTX-loaded poly(lactic-co-glycolic) (PLGA) biomatrices sprayed on intraocular lenses (IOLs) as a drug-delivery implant. METHODS: Hydrophilic and hydrophobic acrylic IOLs were spray-coated with MTX-loaded PLGA...
February 16, 2018: Current Eye Research
https://www.readbyqxmd.com/read/29451638/-association-between-health-anthropometric-indexes-with-physical-fitness-in-physically-active-elderly-women
#4
Pablo Valdés-Badilla, Andrés Godoy-Cumillaf, Jenny Ortega-Spuler, Tomás Herrera-Valenzuela, Samuel Durán-Agüero, José Zapata-Bastias, Rodrigo Vargas-Vitoria, Eduardo Guzmán-Muñoz, Antonio López-Fuenzalida
OBJECTIVE: To associate health anthropometric indexes with physical fitness of elderly women (EW) who participate in physical exercise workshops. MATERIALS AND METHODS: 272 Chilean women over 60 years took part in the study. The variables studied were BMI, waist circumference (WC), waist-height index (WHI) and physical fitness (PF). Correlations were made through the Pearson or Spearman coefficient, and bivariate associations using Pearson's Chi-square and the Fisher's exact test, considering p<0...
November 2017: Salud Pública de México
https://www.readbyqxmd.com/read/29450887/linear-yellow-papules-following-a-cat-scratch
#5
Julia S Lehman, Ashley M Nault, Steven A Smith, Marian T McEvoy
No abstract text is available yet for this article.
February 16, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29450536/administration-of-nitric-oxide-through-a-novel-copper-chitosan-delivery-system-in-human-corneal-and-limbal-epithelial-cell-injury
#6
Vasiliki Tellios, Hong Liu, Nikoleta Tellios, Xiangji Li, Cindy M L Hutnik
Purpose: Nitric oxide (NO) has gained attention for its role in facilitating wound healing by promoting cell migration, while being cytoprotective in a variety of cell types. We determined the efficacy of NO, administered using a novel application of copper-chitosan treatments (Cu-Ch), in facilitating corneal epithelial wound healing using an in vitro model of corneal epithelial and limbal epithelial cell injury. Methods: Human corneal epithelial (HCE) and human limbal epithelial (HLE) cells were monitored under no-scratch (CON), untreated scratch (CS), scratch + plain chitosan composite (0%), scratch + 1% copper solution Cu-Ch (1%), and scratch + 2% copper solution Cu-Ch (2%) conditions...
February 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29448661/study-on-sand-erosion-and-tribological-behavior-of-tio%C3%A2-films-prepared-on-a-glass-surface
#7
Bo Zhang, Junzhong Wang, Zhiming Shi, Quansheng Liu, Guojun Ji
TiO2 films with one, three or five layers were prepared on a glass surface using the sol-gel method. The crystal structure, the surface morphology and the thickness of the films were characterized by X-ray diffraction, atomic force microscopy and ellipsometry. The tribological properties of the TiO2 films were investigated by a tribometer. TiO2 thin films were eroded by sand-air injection. The erosion behavior and mechanism of TiO2 thin films in a sandstorm were analyzed by scanning electron microscopy. The results showed that the films were highly abraded with increased erosion speed and dose of sand...
March 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29448511/preparation-and-in-vitro-evaluation-of-elastic-nanoliposomes-for-topical-delivery-of-highly-skin-permeable-growth-factors
#8
Sang Won Choi, Min-Ho Oak, Eunyoung Yi, Hyun Jung Kim, Jin Woo Park
Percutaneous delivery of growth factors is often used to treat wounds, and for cosmetic purposes, as a way of accelerating healing and skin regeneration, respectively. However, the therapeutic effects of growth factors are diminished by their poor absorption when delivered percutaneously, in addition to their rapid degradation by proteinases. To overcome these obstacles, we constructed two skin-permeable compounds. Basic fibroblast growth factor (bFGF) and vascular endothelial growth factor-A (VEGF-A) were both genetically paired with low-molecular-weight protamine (LMWP), to yield the compounds LMWP-bFGF and LMWP-VEGF-A, respectively...
February 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29447281/peptidic-inhibitors-of-insulin-degrading-enzyme-with-potential-for-dermatological-applications-discovered-via-phage-display
#9
Caitlin N Suire, Sarah Nainar, Michael Fazio, Adam G Kreutzer, Tara Paymozd-Yazdi, Caitlyn L Topper, Caroline R Thompson, Malcolm A Leissring
Insulin-degrading enzyme (IDE) is an atypical zinc-metalloendopeptidase that hydrolyzes insulin and other intermediate-sized peptide hormones, many of which are implicated in skin health and wound healing. Pharmacological inhibitors of IDE administered internally have been shown to slow the breakdown of insulin and thereby potentiate insulin action. Given the importance of insulin and other IDE substrates for a variety of dermatological processes, pharmacological inhibitors of IDE suitable for topical applications would be expected to hold significant therapeutic and cosmetic potential...
2018: PloS One
https://www.readbyqxmd.com/read/29446348/the-effect-of-air-stable-n-doping-through-mild-plasma-on-the-mechanical-property-of-wse2-layers
#10
Linyan Xu, Shuangbei Qian, Yuan Xie, Enxiu Wu, Haicheng Hei, Zhihong Feng, Sen Wu, Xiaodong Hu, Tong Guo, Daihua Zhang
Two-dimensional transition metal dichalcogenides (2D TMDCs) have been widely applied to electronic and optoelectronic device owing to their remarkable material properties. Many studies present the platform for regulating the contact resistance via various doping schemes. Here, we report the alteration of mechanical properties of few top layers of the WSe2 flake which are processed by air stable n-doping of N2O with a constant gas flow through mild plasma and present better manufacturability and friability. The single-line nanoscratching experiments on the WSe2 flakes with different doping time reveal that the manufacturable depths are positively correlated with the exposure time at a certain range and tend to be stable afterwards...
February 15, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29444668/gigantol-inhibits-wnt-%C3%AE-catenin-signaling-and-exhibits-anticancer-activity-in-breast-cancer-cells
#11
Shubin Yu, Zhongyuan Wang, Zijie Su, Jiaxing Song, Liang Zhou, Qi Sun, Shanshan Liu, Shiyue Li, Ying Li, Meina Wang, Guo-Qiang Zhang, Xue Zhang, Zhong-Jian Liu, Desheng Lu
BACKGROUND: Gigantol is a bibenzyl compound derived from several medicinal orchids. This biologically active compound has been shown to have promising therapeutic potential against cancer cells, but its mechanism of action remains unclear. METHODS: The inhibitory effect of gigantol on Wnt/β-catenin signaling was evaluated with the SuperTOPFlash reporter system. The levels of phosphorylated low-density lipoprotein receptor related protein 6 (LRP6), total LRP6 and cytosolic β-catenin were determined by Western blot analysis...
February 14, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29444517/acetyl-coa-synthetase-2-promotes-cell-migration-and-invasion-of-renal-cell-carcinoma-by-upregulating-lysosomal-associated-membrane-protein-1-expression
#12
Lv Yao, Xiaoqiang Guo, Yaoting Gui
BACKGROUND/AIMS: Reprogramming energy metabolism is an emerging hallmark of many cancers, and this alteration is especially evident in renal cell carcinomas (RCCs). However, few studies have been conducted on lipid metabolism. This study investigated the function and mechanism of lipid metabolism-related acetyl-CoA synthetase 2 (ACSS2) in RCC development, cell migration and invasion. METHODS: Quantitative real-time PCR (qRT-PCR) was used to determine the expression of ACSS2 in cancer tissue and adjacent tissue...
February 8, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29444457/brain-region-specific-responses-of-astrocytes-to-an-in-vitro-injury-and-neurotrophins
#13
Andrea Beatriz Cragnolini, Gonzalo Montenegro, Wilma J Friedman, Daniel Hugo Mascó
Astrocytes are a heterogeneous population of glial cells that react to brain insults through a process referred to as astrogliosis. Reactive astrocytes are characterized by an increase in proliferation, size, migration to the injured zone and release of a plethora of chemical mediators such as NGF and BDNF. The aim of this study was to determine whether there are brain region-associated responses of astrocytes to an injury and to the neurotrophins NGF and BDNF. We used the scratch injury model to study the closure of a wound inflicted on a monolayer of astrocytes obtained from cortex, hippocampus or striatum...
February 11, 2018: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/29444194/scratching-beneath-the-surface
#14
Michael A Santos, Andrew A White, Paul S Pottinger
No abstract text is available yet for this article.
February 8, 2018: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/29444101/development-and-characterization-of-two-cell-lines-from-gills-of-atlantic-salmon
#15
Mona C Gjessing, Maria Aamelfot, William N Batts, Sylvie L Benestad, Ole B Dale, Even Thoen, Simon C Weli, James R Winton
Gill disease in Atlantic salmon, Salmo salar L., causes big losses in the salmon farming industry. Until now, tools to cultivate microorganisms causing gill disease and models to study the gill responses have been lacking. Here we describe the establishment and characterization of two cell lines from the gills of Atlantic salmon. Atlantic salmon gill cell ASG-10 consisted of cells staining for cytokeratin and e-cadherin and with desmosomes as seen by transmission electron microscopy suggesting the cells to be of epithelial origin...
2018: PloS One
https://www.readbyqxmd.com/read/29442931/anti-oxidative-and-antibacterial-self-healing-edible-polyelectrolyte-multilayer-film-in-fresh-cut-fruits
#16
Xuefan Liu, Wei Han, Yanxi Zhu, Hongyun Xuan, Jiaoyu Ren, Jianhao Zhang, Liqin Ge
The consumption of fresh-cut fruits is limited because of the oxidation browning and pathogenic bacteria's growth on the fruit surface. Besides, crack of the fresh-keeping film may shorten the preservation time of fruit. In this work, polyelectrolyte multilayer (PEM) film was fabricated by layer-by-layer (LBL) electrostatic deposition method. The film was made by carboxy methylcellulose sodium (CMC) and chitosan (CS). The as-prepared PEM film had good anti-oxidative and antibacterial capability. It inhibited the growth of Gram-negative bacteria and the antibacterial rate was more than 95%...
April 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29442904/self-assembled-tea-tannin-graft-copolymer-as-nanocarriers-for-antimicrobial-drug-delivery-and-wound-healing-activity
#17
Denial Mahata, Ahindra Nag, Golok B Nando, Santi M Mandal, Octavio L Franco
Green chemistry polymers from renewable resources have recently received much more attention from pharmaceutical researchers. However, the appropriate application of a polymer depends on its chemical nature, biocompatibility and microstructure. Here, tannin polyphenols from the common beverage, tea, are used to develop a novel self-assembled porous capsule as a microstructure of hydrogel for versatile biological applications, such as drug delivery, antioxidant and wound healing activity. Hydrogel has been successfully used for the delivery of both anticancer and antimicrobial drugs...
April 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29442627/studies-on-mechanical-biocompatibility-and-antibacterial-activity-of-plasma-sprayed-nano-micron-ceramic-bilayered-coatings-on-ti-6al-4v-alloy-for-biomedical-application
#18
Suganthan Veerachamy, Pearlin Hameed, Dwaipayan Sen, Sitaram Dash, Geetha Manivasagam
Ceramic oxides such as alumina and zirconia are used to fabricate dental and orthopedic implants. However, their usage is limited as they fail due to low fracture toughness. To overcome this issue, ceramic coatings on metallic implants is attempted to have a combined effect of ceramics and metallic materials. This paper reports on the microstructure, phase analysis, mechanical properties, osseointegration and antibacterial activity of three different wear-resistant coatings developed on Ti-6Al-4V alloy which is used widely as orthopedic and dental implants...
July 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29441982/microrna-17-3p-promotes-keratinocyte-cells-growth-and-metastasis-via-targeting-myot-and-regulating-notch1-nf-%C3%AE%C2%BAb-pathways
#19
Hongshan Yan, Kunxiu Song, Guohui Zhang
Wound healing is a fundamental biological process to restore skin integrity. The role of microRNAs (miRNAs) during this process remains elusive. Thus, our study aimed to investigate the biological functions and its molecular mechanisms of miR-17-3p in cutaneous wound healing. Human keratinocyte cell line HaCaT was transfected with miR-17-3p mimic, antisense oligonucleotides (ASO)-miR-17-3p and corresponding controls respectively. After transfection, MTT, flow cytometry, qRT-PCR and western blot were performed to analyze cell viability, colony-formation and cell cycle...
September 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29439314/effects-of-malat1-on-proliferation-and-apo-ptosis-of-human-non-small-cell-lung-cancer-a549-cells-in-vitro-and-tumor-xenograft-growth-in-vivo-by-modulating-autophagy
#20
Jun Ma, Kaiming Wu, Kuanzhi Liu, Rong Miao
OBJECTIVE: To explore the ability of MALAT1 to influence non-small cell lung cancer (NSCLC) A549 cells in vitro and tumor xenograft growth in vivo by modulating autophagy. METHODS: LncRNA MALAT-1 in normal HBE cells and human NSCLC cells was measured. A549 cells were treated with si-MALAT-1, negative control and si-MALAT-1 + rapamycin. The mRNA levels of MALAT-1, P62 and LC3 was determined by the qRT-PCR and the protein levels of autophagy-related proteins by the western blotting...
January 29, 2018: Cancer Biomarkers: Section A of Disease Markers
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