Mariano Martín, Carlos Pablo Modenutti, Mauco Lucas Gil Rosas, Victoria Peyret, Romina Celeste Geysels, Carlos Eduardo Bernal Barquero, Gabriela Sobrero, Liliana Muñoz, Malvina Signorino, Graciela Testa, Mirta Beatriz Miras, Ana María Masini-Repiso, Nora Beatriz Calcaterra, Gabriela Coux, Nancy Carrasco, Marcelo Adrián Martí, Juan Pablo Nicola
CONTEXT: Iodide transport defect (ITD) (Online Mendelian Inheritance in Man #274400) is an uncommon cause of dyshormonogenic congenital hypothyroidism due to loss-of-function variants in the SLC5A5 gene, which encodes the sodium/iodide symporter (NIS), causing deficient iodide accumulation in thyroid follicular cells. OBJECTIVE: To determine the molecular basis of a patient´s ITD clinical phenotype. PATIENT: The propositus was diagnosed with dyshormonogenic congenital hypothyroidism with minimal 99mTc-pertechnetate accumulation in a eutopic thyroid gland...
April 29, 2021: Journal of Clinical Endocrinology and Metabolism