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geriatric oncology

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https://www.readbyqxmd.com/read/29777975/geriatric-analysis-from-prodige-20-randomized-phase-ii-trial-evaluating-bevacizumab-chemotherapy-versus-chemotherapy-alone-in-older-patients-with-untreated-metastatic-colorectal-cancer
#1
T Aparicio, O Bouché, E Francois, F Retornaz, E Barbier, J Taieb, S Kirscher, P-L Etienne, R Faroux, F Khemissa Akouz, F El Hajbi, C Locher, Y Rinaldi, T Lecomte, S Lavau-Denes, M Baconnier, A Oden-Gangloff, D Genet, L Bedenne, E Paillaud
BACKGROUND: Older patients have frailty characteristics that impair the transposition of treatment results found in younger patients. Predictive factors are needed to help with treatment choices for older patients. The PRODIGE 20 study is a randomized phase II study that evaluated chemotherapy associated with bevacizumab (BEV) or not (CT) in patients aged 75 years or older. PATIENTS AND METHODS: Patients underwent a geriatric assessment at randomization and at each evaluation...
May 16, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29773225/-cognitive-decline-in-geriatric-oncology-trends-evaluation-and-treatment
#2
REVIEW
V Antoine, M Courtial, B de Wazieres, A Di Castri, S Duvjnak, L Geronimi, C Labarias, C Le Guillou, A Martin-Allier, D Matelot, C Moitrelle, F Santoni, G Solinas, M Viala
Cancer prevalence increases with aging. Prevalent or incident neurocognitive disorders are frequent in geriatric oncology. Cognitive decline associated with cancer increases the risk of under or over-cancer treatment and makes therapeutic decisions complex. In this context, we present tools to optimize cognitive impairment screening, identification of underlying mechanisms and specific treatments. Geriatric specialists intervention can help global care, social services utilization and patient's orientation when ambulatory cares become difficult...
May 14, 2018: Bulletin du Cancer
https://www.readbyqxmd.com/read/29772281/geriatric-oncology-spirituality-and-palliative-care
#3
Lodovico Balducci
Cancer is a major cause of morbidity and mortality for older individuals. Palliative care is essential to improve the outcome of cancer treatment in terms of quality of life and treatment satisfaction. This review examines the influence of spirituality on aging in general and on the management of older cancer patients. A spiritual perspective has been associated with successful aging, and with better tolerance of physical and emotional stress, including the ability to cope with serious diseases and with isolation...
May 14, 2018: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29747954/role-of-the-geriatrician-primary-care-practitioner-nurses-and-collaboration-with-oncologists-during-cancer-treatment-delivery-for-older-adults-a-narrative-review-of-the-literature
#4
Martine T E Puts, Fay J Strohschein, M Elisabeth Del Giudice, Rana Jin, Allison Loucks, Ana Patricia Ayala, Shabbir H M Alibhai
Cancer is a disease that mostly affects older adults. With the aging of the population there will be a considerable increase in the number of older adults with cancer. Optimal care of the older adult with cancer requires the involvement of many types of health care providers, including oncologists, nurses, primary care practitioners, and geriatricians. In this narrative review, the literature for evidence relating to the roles of and collaboration between geriatricians, primary care practitioners, nurses, and the oncology team during cancer treatment delivery to older adults was examined...
May 7, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29747287/-a-comparative-study-of-comprehensive-geriatric-assessment-in-elder-patients-with-non-hodgkin-s-lymphoma
#5
H Liu, M Gao, D Mei, H X Han, J T Li, J F Bai, C L Zhang, R Feng, J P Wei, Y Tian, T Wang
Objective: To measure the comprehensive geriatric assessment (CGA) in elder non-Hodgkin's Lymphoma (NHL) patients in a cross-sectional study; to compare the differences between Eastern Cooperative Oncology Group (ECOG)-performance status (PS) and CGA. Methods: CGA stratification included the following 3 instrument assessments: activity of daily living (ADL);instrumental activity of daily living (IADL);comorbidity score according to the modified cumulative illness rating score for geriatrics (MCIRS-G). According to CGA and age, NHL patients, aged ≥60 years, were classified as"fit","unfit"and"frail"groups...
May 1, 2018: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29708056/development-of-clinical-pharmacy-in-belgian-hospitals-through-pilot-projects-funded-by-the-government
#6
A Somers, A Spinewine, I Spriet, S Steurbaut, P Tulkens, J D Hecq, L Willems, H Robays, M Dhoore, H Yaras, I Vanden Bremt, M Haelterman
Objectives The goal is to develop clinical pharmacy in the Belgian hospitals to improve drug efficacy and to reduce drug-related problems. Methods From 2007 to 2014, financial support was provided by the Belgian federal government for the development of clinical pharmacy in Belgian hospitals. This project was guided by a national Advisory Working Group. Each funded hospital was obliged to describe yearly its clinical pharmacy activities. Results In 2007, 20 pharmacists were funded in 28 pilot hospitals; this number was doubled in 2009 to 40 pharmacists over 54 institutions, representing more than half of all acute Belgian hospitals...
April 30, 2018: Acta Clinica Belgica
https://www.readbyqxmd.com/read/29699938/black-white-disparity-in-physical-performance-among-older-women-with-newly-diagnosed-non-metastatic-breast-cancer-exploring-the-role-of-inflammation-and-physical-activity
#7
Cynthia Owusu, Mark Schluchter, Siran M Koroukian, Kathryn H Schmitz, Nathan A Berger
OBJECTIVE: To examine racial differences in physical performance among older women with newly diagnosed non-metastatic breast cancer and identify clinical, behavioral and biological factors that might contribute to such disparities. METHODS: This is a cross-sectional study of women aged ≥65 years with newly diagnosed stage I-III breast cancer recruited from ambulatory oncology clinics at an academic center, between September 2010 and August 2015. Participants completed a Comprehensive Geriatric Assessment and laboratory testing for biomarkers of inflammation [interleukin-6 (IL6)] prior to receiving systemic treatment for cancer...
April 23, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29690722/-dynamic-investigation-of-nutritional-risk-in-patients-with-malignant-tumor-during-hospitalization
#8
M W Zhu, J M Wei, W Chen, X Yang, H Y Cui, S N Zhu, P P Zhang, J Xiong, D F Zheng, H J Song, X Y Liang, L Zhang, W Y Xu, H B Wang, G Q Su, L J Feng, T Chen, Y D Wu, H Li, J Q Sun, Y Shi, B D Tong, S M Zhou, X Y Wang, Y H Huang, B M Zhang, J Xu, H Y Zhang, G L Chang, Z Y Jia, S F Chen, J Hu, X W Zhang, H Wang, Z D Li, Y Y Gao, B Gui
Objective: To prospectively investigate the changes in nutritional status of patients with malignant tumors during hospitalization by using nutritional risk screening (NRS2002), and to analyze the correlation between the nutritional status and clinical outcomes . Methods: This was a prospective and parallel research done by multi-center collaboration from 34 hospitals in China from June to September 2014.Hospitalized patients with malignant tumors inthese departments (Department of Gastroenterology, respiratory medicine, oncology, general surgery, thoracic surgery and geriatrics)were investigated...
April 10, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29685381/an-onco-geriatric-approach-to-select-older-patients-for-optimal-treatments-of-pancreatic-adenocarcinoma
#9
Elisabeth Castel-Kremer, Solene De Talhouet, Anne-Laure Charlois, Emmanuelle Graillot, Xavier Chopin-Laly, Mustapha Adham, Brigitte Comte, Catherine Lombard-Bohas, Thomas Walter, Gilles Boschetti
INTRODUCTION: Pancreatic adenocarcinoma affects mainly older patients. Surgery is indicated for localized tumors while chemotherapy alone is proposed in advanced or metastatic tumors. OBJECTIVE: To evaluate the feasibility of standard of care oncologic treatments in this population, the accuracy of the geriatric evaluation to predict the ability of patients to tolerate the recommended treatments and to identify specific geriatric prognosis factors. METHODS: We included, between 2007 and 2014, all consecutive patients over 70 years of age with a pathologically diagnosed pancreatic cancer...
April 20, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29685380/low-levels-of-intra-tumoural-t-cells-in-breast-cancer-identify-clinically-frail-patients-with-shorter-disease-specific-survival
#10
Lisa Speigl, Alexandra Grieb, Nicole Janssen, Sigrid Hatse, Barbara Brouwers, Ann Smeets, Giuseppe Floris, Jithendra Kini Bailur, Cindy Kenis, Patrick Neven, Hans Wildiers, Graham Pawelec, Christopher Shipp
OBJECTIVES: The global health status of older patients with cancer influences their clinical course, but little is known regarding the influence of the immune system on the global health of older patients with cancer. The goal of this study was to assess the relationships between patient fitness/frailty status and survival, and the local tumour immune environment of older patients with breast cancer. MATERIALS AND METHODS: In a cohort of 58 older patients with breast cancer (over 70 years of age), fluorescence microscopy was used to investigate whether levels of intra-tumoural T cells (CD3+) and granulocytic cells (CD15+) could predict patient clinical outcome, and/or whether they correlated with patient physical and mental performance as evaluated by comprehensive geriatric assessment...
April 20, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29683125/factors-associated-with-poor-sleep-in-older-women-diagnosed-with-breast-cancer
#11
Janine Overcash, Alai Tan, Keya Patel, Anne M Noonan
OBJECTIVES: To determine the relationship among gait, grip strength, cognition, depression, pain, and fatigue, and to identify which variables are most predictive of poor sleep. SAMPLE & SETTING: 60 women with breast cancer aged 69 years or older who were receiving treatment in the Senior Adult Oncology Program at the James Cancer Hospital at the Ohio State University. METHODS & VARIABLES: The variables were gait and grip strength (functional domains), cognition, depression, pain, and fatigue...
May 1, 2018: Oncology Nursing Forum
https://www.readbyqxmd.com/read/29678669/using-big-data-in-oncology-to-prospectively-impact-clinical-patient-care-a-proof-of-concept-study
#12
Vérène Dougoud-Chauvin, Jae Jin Lee, Edgardo Santos, Vonetta L Williams, Nicolò M L Battisti, Kavita Ghia, Marina Sehovic, Cortlin Croft, Jongphil Kim, Lodovico Balducci, Julie A Kish, Martine Extermann
OBJECTIVE: Big Data is widely seen as a major opportunity for progress in the practice of personalized medicine, attracting the attention from medical societies and presidential teams alike as it offers a unique opportunity to enlarge the base of evidence, especially for older patients underrepresented in clinical trials. This study prospectively assessed the real-time availability of clinical cases in the Health & Research Informatics Total Cancer Care™ (TCC) database matching community patients with cancer, and the impact of such a consultation on treatment...
April 17, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29670897/searching-for-clinically-relevant-biomarkers-in-geriatric-oncology
#13
REVIEW
Theodora Katsila, George P Patrinos, Dimitrios Kardamakis
Ageing, which is associated with a progressive decline and functional deterioration in multiple organ systems, is highly heterogeneous, both inter- and intraindividually. For this, tailored-made theranostics and optimum patient stratification become fundamental, when decision-making in elderly patients is considered. In particular, when cancer incidence and cancer-related mortality and morbidity are taken into account, elderly patient care is a public health concern. In this review, we focus on oncogeriatrics and highlight current opportunities and challenges with an emphasis on the unmet need of clinically relevant biomarkers in elderly cancer patients...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29669700/a-tribute-to-jimmie-holland-pioneer-for-geriatric-oncology
#14
Christian J Nelson, William P Tew, Arti Hurria
No abstract text is available yet for this article.
April 15, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29667185/geriatric-oncology-mini-focus-issue-call-for-papers
#15
(no author information available yet)
No abstract text is available yet for this article.
April 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29650403/is-age-a-risk-factor-for-depression-among-the-oldest-old-with-cancer
#16
Gil Goldzweig, Lea Baider, Yakir Rottenberg, Elisabeth Andritsch, Jeremy M Jacobs
INTRODUCTION: Age is negatively related to depression among young and middle age patients with cancer. Nevertheless the relationship between age and depression among older patients with cancer is unclear. The goal of the current study is to assess the association of depression with increasing age among older patients with cancer. MATERIALS AND METHODS: Participants were 243 oncology out-patients, aged ≥65, either receiving treatment for active disease or within 6 months of completing treatment for active disease, with a Karnofsky score ≥70...
April 9, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29649847/-special-palliative-care-in-patients-with-non-oncological-diseases
#17
Claudia Bausewein
Palliative medicine has become an integral part of the German healthcare system in recent years. However, patients with non-malignant diseases have less access to palliative care than patients with oncological diseases. These patients comprise a heterogeneous group of chronic lung and heart diseases, neurological and geriatric diseases. Their symptom burden and their palliative care needs are similar to those of oncological patients, but earlier in the disease process. Physical aspects of the disease process are different from psychological, social and spiritual aspects...
April 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29589223/an-analysis-of-the-inclusion-of-medications-considered-potentially-inappropriate-in-older-adults-in-chemotherapy-templates-for-hematologic-malignancies-one-recommendation-for-all
#18
Amy Zhou, Holly M Holmes, Arti Hurria, Tanya M Wildes
BACKGROUND: There remains a paucity of data regarding the use of potentially inappropriate medications (PIMs) in the supportive management of older adults undergoing chemotherapy. Raising awareness among healthcare providers regarding the frequency of their use and potential toxicities may help to minimize the risks to patients. OBJECTIVE: The aim of this study was to evaluate the frequency of six specific classes of medications considered PIMs by the American Geriatrics Society Beers Criteria that are commonly included in the National Comprehensive Cancer Network (NCCN) chemotherapy order templates for hematologic malignancies...
March 27, 2018: Drugs & Aging
https://www.readbyqxmd.com/read/29582192/prevalence-and-risk-of-polypharmacy-among-elderly-cancer-patients-receiving-chemotherapy-in-ambulatory-oncology-setting
#19
REVIEW
Ivy Goh, Olive Lai, Lita Chew
PURPOSE OF REVIEW: This was a single center, retrospective cross-sectional study looking into the incidence and types of drug-related problems (DRPs) detected among elderly cancer patients receiving at least three long-term medications concurrent with IV chemotherapy, and the types of intervention taken to address these DRPs. This paper serves to elucidate the prevalence and risk of polypharmacy in our geriatric oncology population in an ambulatory care setting, to raise awareness on this growing issue and to encourage more resource allocation to address this healthcare phenomenon...
March 26, 2018: Current Oncology Reports
https://www.readbyqxmd.com/read/29545084/celebrating-a-giant-in-geriatric-oncology
#20
EDITORIAL
Martine Extermann
No abstract text is available yet for this article.
March 12, 2018: Journal of Geriatric Oncology
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