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https://www.readbyqxmd.com/read/28550739/optimal-design-of-nanowire-field-effect-troponin-sensors
#1
Amirreza Khodadadian, Kiarash Hosseini, Ali Manzour-Ol-Ajdad, Marjan Hedayati, Reza Kalantarinejad, Clemens Heitzinger
We propose a design strategy for affinity-based biosensors using nanowires for sensing and measuring biomarker concentration in biological samples. Such sensors have been shown to have superior properties compared to conventional biosensors in terms of LOD (limit of detection), response time, cost, and size. However, there are several parameters affecting the performance of such devices that must be determined. In order to solve the design problem, we have developed a comprehensive model based on stochastic transport equations that makes it possible to optimize the sensing behavior...
May 20, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28550456/what-doesn-t-work-for-whom-exploring-heterogeneity-in-responsiveness-to-the-family-check-up-in-early-childhood-using-a-mixture-model-approach
#2
William E Pelham, Thomas J Dishion, Jenn-Yun Tein, Daniel S Shaw, Melvin N Wilson
This study applied latent class analysis to a family-centered prevention trial in early childhood to identify subgroups of families with differential responsiveness to the Family Check-Up (FCU) intervention. The sample included 731 families with 2-year-olds randomized to the FCU or control condition and followed through age 5 with yearly follow-up assessments. A two-step mixture model was used to examine whether specific constellations of family characteristics at age 2 (baseline) were related to intervention response across ages 3, 4, and 5...
May 27, 2017: Prevention Science: the Official Journal of the Society for Prevention Research
https://www.readbyqxmd.com/read/28550377/acceptability-of-and-adherence-to-an-antiretroviral-based-vaginal-microbicide-among-pregnant-women-in-the-united-states
#3
Elizabeth T Montgomery, Lisa M Noguchi, James Y Dai, Jason Pan, Joseph Biggio, Craig Hendrix, Karen Isaacs, D Heather Watts, Jill L Schwartz, Jeanna Piper, Richard Beigi
The MTN-008 trial was the first multi-dose study conducted to evaluate the safety of a microbicide gel (2:1 randomized to tenofovir 1% or hydroxycellulose (HEC) placebo gel) during pregnancy. The study aim was to evaluate safety, tolerability and pharmacokinetics of the study products. Procedures included daily gel administration, with Day 0 and Day 6 in clinic, and Days 1-5 at home. Because pregnancy may pose unique challenges to consistent gel use and acceptability, evaluation of adherence and acceptability was a secondary objective of the trial...
May 26, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28550117/comparative-exploration-of-multidimensional-flow-cytometry-software-a-model-approach-evaluating-t-cell-polyfunctional-behavior
#4
Timothy T Spear, Michael I Nishimura, Patricia E Simms
Advancement in flow cytometry reagents and instrumentation has allowed for simultaneous analysis of large numbers of lineage/functional immune cell markers. Highly complex datasets generated by polychromatic flow cytometry require proper analytical software to answer investigators' questions. A problem among many investigators and flow cytometry Shared Resource Laboratories (SRLs), including our own, is a lack of access to a flow cytometry-knowledgeable bioinformatics team, making it difficult to learn and choose appropriate analysis tool(s)...
May 26, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28550007/associations-between-maternal-depressive-symptoms-and-nonresponsive-feeding-styles-and-practices-in-mothers-of-young-children-a-systematic-review
#5
Ana Cristina Lindsay, Tatiana Mesa, Mary L Greaney, Sherrie F Wallington, Julie A Wright
BACKGROUND: Childhood obesity is a significant global public health problem due to increasing rates worldwide. Growing evidence suggests that nonresponsive parental feeding styles and practices are important influences on children's eating behaviors and weight status, especially during early childhood. Therefore, understanding parental factors that may influence nonresponsive parental feeding styles and practices is significant for the development of interventions to prevent childhood obesity...
May 26, 2017: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/28550004/an-mhealth-app-for-supporting-quitters-to-manage-cigarette-cravings-with-short-bouts-of-physical-activity-a-randomized-pilot-feasibility-and-acceptability-study
#6
Mary Hassandra, Taru Lintunen, Martin S Hagger, Risto Heikkinen, Mauno Vanhala, Tarja Kettunen
BACKGROUND: While gains in reducing smoking rates in Finland have been made, prevalence rates are still substantial. Relapse rates among smokers engaged in quit-smoking programs are high. Physical activity has been proposed as one means to help smokers manage cravings. Software and apps on mobile phone and handheld devices offer an opportunity to communicate messages on how to use physical activity to manage cravings as part of quit-smoking programs. OBJECTIVE: We aimed to test the feasibility, acceptability, usability, and preliminary efficacy of an mHealth mobile phone app, Physical activity over Smoking (PhoS), to assist smokers in quitting smoking in a randomized controlled trial...
May 26, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28549949/recent-advancements-in-liposomes-targeting-strategies-to-cross-blood-brain-barrier-bbb-for-the-treatment-of-alzheimer-s-disease
#7
REVIEW
Mukta Agrawal, Ajazuddin, Dulal K Tripathi, Swarnlata Saraf, Shailendra Saraf, Sophia G Antimisiaris, Spyridon Mourtas, Margareta Hammarlund-Udenaes, Amit Alexander
In this modern era, with the help of various advanced technologies, medical science has overcome most of the health-related issues successfully. Though, some diseases still remain unresolved due to various physiological barriers. One such condition is Alzheimer; a neurodegenerative disorder characterized by progressive memory impairment, behavioral abnormalities, mood swing and disturbed routine activities of the person suffering from. It is well known to all that the brain is entirely covered by a protective layer commonly known as blood brain barrier (BBB) which is responsible to maintain the homeostasis of brain by restricting the entry of toxic substances, drug molecules, various proteins and peptides, small hydrophilic molecules, large lipophilic substances and so many other peripheral components to protect the brain from any harmful stimuli...
May 23, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28549830/high-virulence-of-methicillin-resistant-staphylococcus-aureus-st30-sccmecivc-spat019-the-dominant-community-associated-clone-in-argentina
#8
Silvina Fernandez, Camila Ledo, Santiago Lattar, Mariángeles Noto Llana, Andrea Mendoza Bertelli, Sabrina Di Gregorio, Daniel O Sordelli, Marisa I Gómez, Marta E Mollerach
Community-acquired methicillin resistant Staphylococcus aureus emerged as a worldwide health problem in the last few years. In Argentina, it is found in 70% of skin and skin structure infections in previously healthy adult patients and causes severe invasive diseases. The ST30-SCCmecIVc-spat019 clone is predominant in adult infections and has displaced the previously prevalent ST5-SCCmecIVa-spat311 clone in community settings. In the present work we compared the virulence of both clones in order to explain the displacement, and found that ST30-IVc is associated with invasive infections in adult patients from Argentina and possesses a different virulence-associated genes profile compared to ST5-IVa...
May 15, 2017: International Journal of Medical Microbiology: IJMM
https://www.readbyqxmd.com/read/28549577/-child-behaviour-problems-and-parenting-skills-of-mothers-in-environments-of-intimate-partner-violence
#9
Ana Rosser Limiñana, Raquel Suriá Martínez, Miguel Ángel Mateo Pérez
OBJECTIVE: To assess the behavioural problems of children who have been exposed to intimate partner violence situations, and the moderating effect of mother parenting. METHOD: We analysed, using the Child Behavior CheckList, behavioural problems of 46 children between 6 and 16 years, and the relationship between the detected problems and parenting skills shown in the mother-child interaction in shelters. RESULTS: Increased behavioural problems were detected in children, compared with normative population...
May 23, 2017: Gaceta Sanitaria
https://www.readbyqxmd.com/read/28549424/high-intensity-therapist-guided-internet-based-cognitive-behavior-therapy-for-alcohol-use-disorder-a-pilot-study
#10
Christopher Sundström, Martin Kraepelien, Niels Eék, Claudia Fahlke, Viktor Kaldo, Anne H Berman
BACKGROUND: A large proportion of individuals with alcohol problems do not seek psychological treatment, but access to such treatment could potentially be increased by delivering it over the Internet. Cognitive behavior therapy (CBT) is widely recognized as one of the psychological treatments for alcohol problems for which evidence is most robust. This study evaluated a new, therapist-guided internet-based CBT program (entitled ePlus) for individuals with alcohol use disorders. METHODS: Participants in the study (n = 13) were recruited through an alcohol self-help web site ( www...
May 26, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28549355/predictors-of-language-gains-among-school-age-children-with-language-impairment-in-the-public-schools
#11
Laura M Justice, Hui Jiang, Jessica A Logan, Mary Beth Schmitt
Purpose: This study aimed to identify child-level characteristics that predict gains in language skills for children with language impairment who were receiving therapy within the public schools. The therapy provided represented business-as-usual speech/language treatment provided by speech-language pathologists in the public schools. Method: The sample included 272 kindergartners and first-graders with language impairment who participated in a larger study titled "Speech-Therapy Experiences in the Public Schools...
May 26, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/28549297/diabetes-care-provider-perceptions-on-family-challenges-of-pediatric-type-1-diabetes
#12
Maria J Redondo, Chishinga S Callender, Caroline Gonynor, Dora Cantu, Karen W Cullen, Barbara Anderson, Debbe Thompson
Pediatric healthcare providers' perspectives on barriers to diabetes self-management among youth with type 1 diabetes and strategies to overcome them were explored qualitatively. Family conflict about diabetes care was viewed as a common problem, addressable by behavioral interventions to improve communication and promote family teamwork in diabetes management responsibilities.
May 16, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28548919/a-novel-method-for-quanitifying-comfort-in-child-passengers-demonstrates-an-association-between-child-restraint-comfort-and-errors-in-use-of-booster-seats
#13
Cameron K Fong, Lynne E Bilston, Gunther Paul, Julie Brown
OBJECTIVE: Misuse of child restraint systems is a widespread and long-standing problem impacting risk of injury and death in car crashes. Discomfort has been suggested as a causative factor for misuse, particularly in errors introduced by children while they use the restraints. However, the relationship between comfort and errors in use has never been studied. In this study we examine the reliability and sensitivity of a newly developed observational method for assessing comfort in children in vehicles...
May 29, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28547821/effects-of-sleep-on-substance-use-in-adolescents-a-longitudinal-perspective
#14
Tam T Nguyen-Louie, Ty Brumback, Matthew J Worley, Ian M Colrain, Georg E Matt, Lindsay M Squeglia, Susan F Tapert
Substance use (SU) and sleep problems appear interrelated, but few studies have examined the influence of adolescent sleep patterns on development of SU disorders. This study prospectively examined the influence of sleep habits on subsequent SU in youth who later transitioned into heavy drinking. At time 1 (T1), participants (n = 95) were substance-naive 12- to 14-year-olds. Path-analytic models examined whether the effects of T1 risk factors (familial SU disorder, inhibition control, and externalizing and internalizing traits) on time 3 (M = 19...
May 26, 2017: Addiction Biology
https://www.readbyqxmd.com/read/28547408/predictors-of-parent-teacher-agreement-in-youth-with-autism-spectrum-disorder-and-their-typically-developing-siblings
#15
Elizabeth A Stratis, Luc Lecavalier
This study evaluated the magnitude of informant agreement and predictors of agreement on behavior and emotional problems and autism symptoms in 403 children with autism and their typically developing siblings. Parent-teacher agreement was investigated on the Child Behavior Checklist (CBCL) and Social Responsiveness Scale (SRS). Agreement between parents and teachers fell in the low to moderate range. Multiple demographic and clinical variables were considered as predictors, and only some measures of parent broad autism traits were associated with informant agreement...
May 25, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28546916/liquid-metal-phagocytosis-intermetallic-wetting-induced-particle-internalization
#16
Jianbo Tang, Xi Zhao, Jing Li, Yuan Zhou, Jing Liu
A biomimetic cellular-eating phenomenon in gallium-based liquid metal to realize particle internalization in full-pH-range solutions is reported. The effect, which is called liquid metal phagocytosis, represents a wet-processing strategy to prepare various metallic liquid metal-particle mixtures through introducing excitations such as an electrical polarization, a dissolving medium, or a sacrificial metal. A nonwetting-to-wetting transition resulting from surface transition and the reactive nature of the intermetallic wetting between the two metallic phases are found to be primarily responsible for such particle-eating behavior...
May 2017: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/28546737/racial-socialization-private-regard-and-behavior-problems-in-african-american-youth-global-self-esteem-as-a-mediator
#17
BreAnna L Davis, Mia A Smith-Bynum, Farzana T Saleem, Tiffany Francois, Sharon F Lambert
Racial socialization messages appear to have varying impacts on the adjustment of African American youth. To further explore this, we examined how two types of racial socialization messages might influence African American youth internalizing and externalizing behavior. The Youth Self Report was used to measure these behavior outcomes. Given that racial socialization messages may not be directly linked to behavior outcomes, we considered private regard, an aspect of racial identity, to serve as a mediator. Additionally, we examined global self-esteem as a mediator of the complex dynamic between racial socialization messages and behavior outcomes...
March 2017: Journal of Child and Family Studies
https://www.readbyqxmd.com/read/28546537/basin-stability-for-chimera-states
#18
Sarbendu Rakshit, Bidesh K Bera, Matjaž Perc, Dibakar Ghosh
Chimera states, namely complex spatiotemporal patterns that consist of coexisting domains of spatially coherent and incoherent dynamics, are investigated in a network of coupled identical oscillators. These intriguing spatiotemporal patterns were first reported in nonlocally coupled phase oscillators, and it was shown that such mixed type behavior occurs only for specific initial conditions in nonlocally and globally coupled networks. The influence of initial conditions on chimera states has remained a fundamental problem since their discovery...
May 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28546138/mental-health-mobile-apps-for-preadolescents-and-adolescents-a-systematic-review
#19
REVIEW
Rebecca Grist, Joanna Porter, Paul Stallard
BACKGROUND: There are an increasing number of mobile apps available for adolescents with mental health problems and an increasing interest in assimilating mobile health (mHealth) into mental health services. Despite the growing number of apps available, the evidence base for their efficacy is unclear. OBJECTIVE: This review aimed to systematically appraise the available research evidence on the efficacy and acceptability of mobile apps for mental health in children and adolescents younger than 18 years...
May 25, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28545758/the-role-of-affect-management-for-hiv-risk-reduction-for-youth-in-alternative-schools
#20
Larry K Brown, Laura Whiteley, Christopher D Houck, Lacey K Craker, Ashley Lowery, Nancy Beausoleil, Geri Donenberg
OBJECTIVE: Adolescents in alternative schools for behavioral and emotional problems have an earlier sexual onset and higher rates of sexual risk than their peers. They also often have difficulty managing strong emotions, which can impair sexual decision making. Human immunodeficiency virus (HIV) prevention programs for these adolescents may be most effective if skills for coping with strong emotions during sexual situations are included. METHOD: This article reports the 6-month outcomes of a three-arm randomized controlled trial comparing an HIV prevention intervention with affect management (AM) to a standard, skills-based HIV prevention intervention (SB), and a general health promotion intervention (HP)...
June 2017: Journal of the American Academy of Child and Adolescent Psychiatry
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