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Piero Ruscitti, Domenico Paolo Emanuele Margiotta, Federica Macaluso, Daniela Iacono, Francesca D'Onofrio, Giacomo Emmi, Fabiola Atzeni, Marcella Prete, Federico Perosa, Piercarlo Sarzi-Puttini, Lorenzo Emmi, Francesco Paolo Cantatore, Giovanni Triolo, Antonella Afeltra, Roberto Giacomelli, Gabriele Valentini
Several studies have pointed out a significant association between rheumatoid arthritis (RA) and accelerated atherosclerosis. At the best of our knowledge, no such study has been carried out in a large Italian series and, in this study, we aimed to investigate the prevalence of both subclinical atherosclerosis and history of cardiovascular events (CVEs), in patients consecutively admitted from January 1, 2015 to December 31, 2015 to Rheumatology Units throughout the whole Italy.Centers members of GIRRCS (Gruppo Italiano di Ricerca in Reumatologia Clinica e Sperimentale) were invited to enrol patients consecutively admitted from January 1, 2015 to December 31, 2015 and satisfying American College of Rheumatology/ European League Against Rheumatism criteria for RA and to investigate each of them for: traditional cardiovascular risk factors: sex, age, smoking habit, total cholesterol, triglycerides, glycaemia, high blood pressure, metabolic syndrome (MS), type 2 diabetes (T2D); RA features: disease duration as assessed from the first symptom, disease activity as evaluated by DAS28, radiographic damage as assessed by hands and feet x-ray, and previous joint surgery; prevalence of both subclinical atherosclerosis and history of CVEs...
October 2017: Medicine (Baltimore)
João Eurico Fonseca
No abstract text is available yet for this article.
July 2017: Acta Reumatológica Portuguesa
María Auxiliadora Martín-Martínez, Jose Luis Andreu-Sanchez, Fernando Sanchez-Alonso, Hector Corominas, Jose Javier Perez-Venegas, Jose Andres Roman-Ivorra, Mercedes Alperi, Ricardo Blanco-Alonso, Rafael Caliz, Eugenio Chamizo-Carmona, Jenaro Graña-Gil, Blanca Hernández, Carlos Marras, Ramon Mazzucchelli, Julio Antonio Medina Luezas, Antonio Naranjo-Hernández, Ana Ortiz, Rosa Roselló, Ginés Sanchez-Nievas, Raimon Sanmartí, Paloma Vela-Casasempere
OBJECTIVE: The current guidelines in the treatment of rheumatoid arthritis (RA) include the early diagnosis and early use of disease modifying drugs to achieve remission or low disease activity level, known as "Treat to Target" (T2T). The objective of this study is to develop a composite indicator (CI) to evaluate the quality of care in the management of patients with RA, according to the T2T strategy and other general recommendations concerning the management of these patients. MATERIAL AND METHOD: The phases of the construction of the CI were: 1) selection of quality criteria through expert judgment; 2) prioritization of the criteria, according to relevance and feasibility, applying the Delphi methodology (two rounds) involving 20 experts; 3) design of quality indicators; and 4) calculation of the weighted CI, using the mean value in relevance and feasibility granted by the experts...
August 5, 2017: Reumatología Clinica
Virginia Pascual-Ramos, Diana Elsa Flores-Alvarado, Margarita Portela-Hernández, María Del Rocío Maldonado-Velázquez, Luis Manuel Amezcua-Guerra, Judith López-Zepeda, Everardo Álvarez, Nadina Rubio, Olga Vera Lastra, Miguel Ángel Saavedra, César Alejandro Arce-Salinas
BACKGROUND: The Mexican Accreditation Council for Rheumatology annually certifies trainees in Rheumatology using a multiple-choice test and an objective structured clinical examination (OSCE). Since 2015, candidate's communication skills (CS) have been rated by both patients and by physician examiners and correlated with results on the OSCE. This study compared the CS from candidates to annual accreditation in Rheumatology as rated by patients and by physician examiners, and assessed whether these correlated with candidate's performance in the OSCE...
July 26, 2017: Reumatología Clinica
Claudia Diniz Lopes Marques, Angela Luzia Branco Pinto Duarte, Aline Ranzolin, Andrea Tavares Dantas, Nara Gualberto Cavalcanti, Rafaela Silva Guimarães Gonçalves, Laurindo Ferreira da Rocha Junior, Lilian David de Azevedo Valadares, Ana Karla Guedes de Melo, Eutilia Andrade Medeiros Freire, Roberto Teixeira, Francisco Alves Bezerra Neto, Marta Maria das Chagas Medeiros, Jozélio Freire de Carvalho, Mario Sergio F Santos, Regina Adalva de L Couto Océa, Roger A Levy, Carlos Augusto Ferreira de Andrade, Geraldo da Rocha Castelar Pinheiro, Mirhelen Mendes Abreu, José Fernando Verztman, Selma Merenlender, Sandra Lucia Euzebio Ribeiro, Izaias Pereira da Costa, Gecilmara Pileggi, Virginia Fernandes Moça Trevisani, Max Igor Banks Lopes, Carlos Brito, Eduardo Figueiredo, Fabio Queiroga, Tiago Feitosa, Angélica da Silva Tenório, Gisela Rocha de Siqueira, Renata Paiva, José Tupinambá Sousa Vasconcelos, Georges Christopoulos
Chikungunya fever has become an important public health problem in countries where epidemics occur because half of the cases progress to chronic, persistent and debilitating arthritis. Literature data on specific therapies at the various phases of arthropathy caused by chikungunya virus (CHIKV) infection are limited, lacking quality randomized trials assessing the efficacies of different therapies. There are a few studies on the treatment of musculoskeletal manifestations of chikungunya fever, but these studies have important methodological limitations...
2017: Revista Brasileira de Reumatologia
Virginia Pascual-Ramos, Gabriel Medrano-Ramírez, Eunice Solís-Vallejo, Ana Guilaisne Bernard-Medina, Diana Elsa Flores-Alvarado, Margarita Portela-Hernández, María Del Rocío Maldonado-Velázquez, Luis Javier Jara-Quezada, Luis Manuel Amezcua-Guerra, Judith López-Zepeda, Miguel Ángel Saavedra, César Alejandro Arce-Salinas
BACKGROUND: The Mexican Accreditation Council for Rheumatology certifies trainees (TR) on an annual basis using both a multiple-choice question (MCQ) test and an objective structured clinical examination (OSCE). For 2013 and 2014, the OSCE pass mark (PM) was set by criterion referencing as ≥6 (CPM), whereas overall rating of borderline performance method (BPM) was added for 2015 and 2016 accreditations. We compared OSCE TR performance according to CPM and BPM, and examined whether correlations between MCQ and OSCE were affected by PM...
February 1, 2017: Reumatología Clinica
Rosario García-Vicuña, María Auxiliadora Martín-Martínez, María Rosa Gonzalez-Crespo, Jesús Tornero-Molina, Antonio Fernández-Nebro, Francisco Javier Blanco-García, Ricardo Blanco-Alonso, Sara Marsal-Barril
To establish a set of recommendations for the management of patients diagnosed with rheumatoid arthritis (RA) who cannot be treated with methotrexate (MTX) due to contraindications, drug toxicity or lack of adherence, and to establish therapeutic strategies more effective and safer in these RA patients. A qualitative analysis of the scientific evidence available to June 2015. The 2-round Delphi technique of consensus was used to collect and establish expert opinion based on the participants' clinical experience when only low quality evidence was available...
May 2017: Reumatología Clinica
M Lorenzin, A Ortolan, P Frallonardo, S Vio, C Lacognata, F Oliviero, L Punzi, R Ramonda
Our aim was to determine the prevalence of spine and sacroiliac joint (SIJ) lesions on magnetic resonance imaging (MRI) in patients with early axial spondyloarthritis (axSpA) and their correlation with disease activity indices. Sixty patients with low back pain (LBP) (≥3 months, ≤2 years, onset ≤45 years), attending the SpA-clinic of the Unità Operativa Complessa Reumatologia of Padova [SpondyloArthritis-Caught-Early (SPACE) study], were studied following a protocol including physical examination, questionnaires, laboratory tests, X-rays and spine and SIJ MRI...
September 9, 2016: Reumatismo
Heber Garagarza-Mariscal, José Dionisio Castillo-Ortiz, César Ramos-Remus
No abstract text is available yet for this article.
March 2016: Gaceta Médica de México
Mónica Fernández Castro, Jose Luis Andreu, Carlos Sánchez-Piedra, Víctor Martínez Taboada, Alejandro Olivé, José Rosas, Fernando Sánchez-Alonso
OBJECTIVE: To describe the objectives and methods of the Spanish Society of Rheumatology primary Sjögren syndrome (pSS) registry (SJOGREN-SER) METHODS: This is a multicenter descriptive transversal study of a cohort of pSS patients fulfilling European/American consensus criteria collected from Rheumatology clinics all over Spain. Patients were included by randomisation from an anonymised list provided by every department. Data were collected by reviewing clinical records and an interviewing the patients...
July 2016: Reumatología Clinica
Licia Maria Henrique da Mota, Bóris Afonso Cruz, Claiton Viegas Brenol, Daniel Feldman Pollak, Geraldo da Rocha Castelar Pinheiro, Ieda Maria Magalhães Laurindo, Ivânio Alves Pereira, Jozélio Freire de Carvalho, Manoel Barros Bertolo, Marcelo de Medeiros Pinheiro, Max Victor Carioca Freitas, Nilzio Antônio da Silva, Paulo Louzada-Júnior, Percival Degrava Sampaio-Barros, Rina Dalva Neubarth Giorgi, Rodrigo Aires Corrêa Lima, Luis Eduardo Coelho Andrade
The treatment of autoimmune rheumatic diseases has gradually improved over the last half century, which has been expanded with the contribution of biological therapies or immunobiopharmaceuticals. However, we must be alert to the possibilities of undesirable effects from the use of this class of medications. The Brazilian Society of Rheumatology (Sociedade Brasileira de Reumatologia/SBR) produced a document based on a comprehensive literature review on the safety aspects of this class of drugs, specifically with regard to the treatment of rheumatoid arthritis (RA) and spondyloarthritides...
May 2015: Revista Brasileira de Reumatologia
Luis Felipe Flores-Suárez, Marco A Alba
INTRODUCTION: Respiratory manifestations in antineutrophil cytoplasmic antibody-associated vasculitis (AASV) are common, though their suspicion is lower than expected in respiratory devoted centers, with few descriptions coming from them. OBJECTIVE: To describe the clinical, paraclinical and radiological manifestations, plus the prognosis of AASV patients seen in a respiratory referral center in Mexico City. MATERIAL AND METHODS: Retrospective review of patients with final diagnosis of AASV, based on the American College of Rheumatology criteria and the 1994 Chapel Hill Consensus Conference Nomenclature, from 1982 to 2010...
March 2015: Gaceta Médica de México
J Saavedra-Lozano, C Calvo, R Huguet Carol, C Rodrigo, E Núñez, I Obando, P Rojo, R Merino, C Pérez, F J Downey, E Colino, J J García, M J Cilleruelo, F Torner, L García
This is a Consensus Document of the Spanish Society of Paediatric Infectious Diseases (Sociedad Española de Infectología Pediatrica), Spanish Society of Paediatric Rheumatology (Sociedad Española de Reumatología Pediátrica) and the Spanish Society of Paediatric Orthopaedics (Sociedad Española de Ortopedia Pediátrica), on the treatment of uncomplicated acute osteomyelitis and septic arthritis. A review is presented on the medical and surgical treatment of acute osteoarticular infection, defined as a process with less than 14 days of symptomatology, uncomplicated and community-acquired...
April 2015: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
J Saavedra-Lozano, C Calvo, R Huguet Carol, C Rodrigo, E Núñez, C Pérez, R Merino, P Rojo, I Obando, F J Downey, E Colino, J J García, M J Cilleruelo, F Torner, L García
This is a Consensus Document of the Sociedad Española de Infectología Pediátrica, Sociedad Española de Reumatología Pediátrica and Sociedad Española de Ortopedia Pediátrica on the aetiology and diagnosis of uncomplicated acute osteomyelitis and septic arthritis. A review is presented of the aetiopathogenesis and pathophysiology of acute osteoarticular infection defined as a process with less than 14 days of symptomatology, uncomplicated, and community-acquired. The diagnostic approach to these conditions is summarised based on the best available scientific knowledge...
September 2015: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
João Eurico Fonseca, João Gonçalves, Filipe Araújo, Inês Cordeiro, Filipa Teixeira, Helena Canhão, José António Pereira da Silva, Sandra Garcês, Luís Cunha Miranda, Sofia Ramiro, Ana Roxo, Fernando M Pimentel-Santos, Viviana Tavares, Adriano Neto, Alexandre Sepriano, Armando Malcata, Augusto Faustino, Cândida Silva, Catarina Ambrósio, Cátia Duarte, Cláudia Miguel, Filipe Barcelos, Helena Santos, Inês Cunha, João Carlos Ramos, José António Melo Gomes, José Bravo Pimentão, Lúcia Costa, Luís Maurício, Margarida Silva, Miguel Bernardes, Mónica Bogas, Paulo Clemente Coelho, Paulo Monteiro, Renata Aguiar, Rui André, Rui Leitão, Sofia Pimenta, Tiago Meirinhos, Susana Fernandes, Vera Las, Walter Castelão
Biotechnological drugs have become a fundamental resource for the treatment of rheumatic patients. Patent expiry of some of these drugs created the opportunity for biopharmaceutical manufacturers to develop biosimilar drugs intended to be as efficacious as the originator product but with a lower cost to healthcare systems. Due to the complex manufacturing process and highly intricate structure of biologicals, a biosimilar can never be an exact copy of its reference product. Consequently, regulatory authorities issued strict preclinical and clinical guidelines to ensure safety and efficacy equivalence and, in September 2013, the biosimilar of infliximab was the first biosimilar monoclonal antibody to be authorized for use in the European Union...
January 2014: Acta Reumatológica Portuguesa
Sueli Carneiro, Valderílio Feijó Azevedo, Rubens Bonfiglioli, Roberto Ranza, Célio Roberto Gonçalves, Mauro Keiserman, Eduardo de Souza Meirelles, Marcelo de Medeiros Pinheiro, Antonio Carlos Ximenes, Wanderley Bernardo, Percival Degrava Sampaio-Barros
No abstract text is available yet for this article.
May 2013: Revista Brasileira de Reumatologia
M Victoria Hernández, Raimon Sanmartí, Juan D Cañete, Miguel A Descalzo, Mercè Alsina, Loreto Carmona, Juan J Gomez-Reino
OBJECTIVE: To analyze the incidence rate (IR) and risk factors of cutaneous adverse events (CAE) in patients with chronic inflammatory rheumatic diseases treated with tumor necrosis factor (TNF) antagonists. METHODS: We analyzed all patients from the BIOBADASER (Base de Datos de Productos Biológicos de la Sociedad Española de Reumatología) registry treated with a TNF antagonist (infliximab, etanercept, or adalimumab). Data collected included age, sex, diagnosis and duration of rheumatic disease, type of TNF antagonist, and concomitant treatment...
December 2013: Arthritis Care & Research
Jaime Calvo-Alén, Lucía Silva-Fernández, Eduardo Úcar-Angulo, José María Pego-Reigosa, Alejandro Olivé, Carmen Martínez-Fernández, Víctor Martínez-Taboada, José Luis Marenco, Estíbaliz Loza, Javier López-Longo, Juan Jesús Gómez-Reino, María Galindo-Izquierdo, Antonio Fernández-Nebro, María José Cuadrado, María Ángeles Aguirre-Zamorano, Antonio Zea-Mendoza, Iñigo Rúa-Figueroa
OBJECTIVE: To provide a reference to rheumatologists and other physicians involved in the treatment of systemic lupus erythematosus (SLE) who are using, or about to use biologic therapies. METHODS: Recommendations were developed following a nominal group methodology and based on systematic reviews. The level of evidence and degree of recommendation were classified according to a model proposed by the Center for Evidence Based Medicine at Oxford. The level of agreement was established through a Delphi technique...
September 2013: Reumatología Clinica
Iñigo Rúa-Figueroa, Francisco Javier López-Longo, Jaime Calvo-Alén, María Galindo-Izquierdo, Estíbaliz Loza, M Jesús García de Yebenes, José M Pego-Reigosa
OBJECTIVE: To describe the objectives, design and methods of the Spanish Society of Rheumatology systemic lupus erythematosus (SLE) registry (RELESSER). METHODS: Multicenter, hospital-based registry, with retrospective collection of data from a large representative sample of adult patients with SLE (1997 ACR criteria) attending Spanish rheumatology services. The registry includes demographic data, frequent and infrequent (<1%) clinical manifestations, information about activity, damage, severity, comorbidity, treatments and mortality, collecting 359 variables per patient, with highly standardized definitions...
January 2014: Reumatología Clinica
Adriana Danowski, Jozelia Rego, Adriana M Kakehasi, Andreas Funke, Jozelio Freire de Carvalho, Isabella V S Lima, Alexandre Wagner Silva de Souza, Roger A Levy
The antiphospholipid syndrome (APS) is a systemic autoimmune disease characterized by arterial and venous thrombosis, gestational morbidity and presence of elevated and persistently positive serum titers of antiphospholipid antibodies. The treatment of APS is still controversial, because any therapeutic decision potentially faces the risk of an insufficient or excessive antithrombotic coverage associated with anticoagulation and its major adverse effects. This guideline was elaborated from nine relevant clinical questions related to the treatment of APS by the Committee of Vasculopathies of the Brazilian Society of Rheumatology...
April 2013: Revista Brasileira de Reumatologia
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