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Paula K Lorgelly
No abstract text is available yet for this article.
March 20, 2018: PharmacoEconomics Open
Maria Kamusheva, Mariya Vassileva, Alexandra Savova, Manoela Manova, Guenka Petrova
Background: Policy makers face a lot of challenges in the process of drug reimbursement decision-making, especially in the context of entering the market of more and more innovative medicinal products (MPs). The aim of the current study is to make an overview of the reimbursement system development and to evaluate the access of innovative medicines, which have entered the EU-market in the period 2015-2017, in Bulgaria as reference example for middle-income European country. Methods: A literature and a legislative systematic review regarding the Bulgarian reimbursement system as well as a defining the number of available innovative reimbursed MPs in 2017 in Bulgaria was made...
2018: Frontiers in Public Health
Xinyu Wu, Huan Sun, Xiaoqin Zhou, Ji Wang, Jing Li
BACKGROUND: Increasing numbers of systematic reviews (SRs) on total knee arthroplasty (TKA) and total hip arthroplasty (THA) have been published in recent years, but their quality has been unclear. The purpose of this study is to evaluate the methodological quality of SRs on TKA and THA. METHODS: We searched Ovid-Medline, Ovid-Embase, Cochrane Databases (including HTA, DARE, and CDSR), CBM, CNKI, Wang Fang, and VIP, from January 2014 to December 2015 for THA and TKA...
March 16, 2018: BMC Medical Research Methodology
Tatjana Barišić, Vjekoslav Mandić, Anja Vasilj, Dejan Tiric
OBJECTIVE: To determine the frequency of subclinical hypothyroidism in women with pathological pregnancies and the association between elevated thyroid-stimulating hormone (TSH) and pregnancy outcome. SUBJECTS AND METHODS: A cross-sectional prospective study investigated value of TSH and free thyroxine (FT4) in: 1. pregnant women with hypertension (HTA) (N = 62) or preeclampsia (PE) (N = 50), 2.women with gestational diabetes mellitus (GDM) (N = 92) in pregnancy and 3...
March 14, 2018: Journal of Maternal-fetal & Neonatal Medicine
Marta O Soares, Simon Walker, Stephen J Palmer, Mark J Sculpher
In recent years, Health Technology Assessment (HTA) processes specific to diagnostics and prognostic tests have been created in response to the increased pressure on health systems to decide not only which tests should be used in practice but also the best way to proceed, clinically, from the information they provide. These technologies differ in the way value is accrued to the population of users, depending critically on the value of downstream health care choices. This paper defines an analytical framework for establishing the value of diagnostic and prognostic tests for HTA in a way that is consistent with methods used for the evaluation of other health care technologies...
March 1, 2018: Medical Decision Making: An International Journal of the Society for Medical Decision Making
Tarang Sharma, Moni Choudhury, Juan Carlos Rejón-Parrilla, Pall Jonsson, Sarah Garner
BACKGROUND: The National Institute for Health and Care Excellence (NICE) was established in 1999 and provides national guidance and advice to improve health and social care. Several steps in the research cycle have been identified that can support the reduction of waste that occurs in biomedical research. The first step in the process is ensuring appropriate research priority setting occurs so only the questions that are needed to fill existing gaps in the evidence are funded. This paper summarises the research priority setting processes at NICE...
March 8, 2018: BMJ Open
Franziska Nickel, Janina Barth, Peter L Kolominsky-Rabas
BACKGROUND: This systematic review aims to review the literature on trial-based economic evaluations of non-pharmacological interventions directly targeted at persons with dementia as well as persons with mild cognitive impairment and their respective caregivers. METHODS: A systematic literature research was conducted for the timeframe from 2010 to 2016 in the following databases: Centre for Reviews and Dissemination, EconLit, Embase, Cochrane Library, PsycINFO and PubMed...
March 9, 2018: BMC Geriatrics
Giovanni Improta, Mario Alessandro Russo, Maria Triassi, Giuseppe Converso, Teresa Murino, Liberatina Carmela Santillo
Health technology assessments (HTAs) are often difficult to conduct because of the decisive procedures of the HTA algorithm, which are often complex and not easy to apply. Thus, their use is not always convenient or possible for the assessment of technical requests requiring a multidisciplinary approach. This paper aims to address this issue through a multi-criteria analysis focusing on the analytic hierarchy process (AHP). This methodology allows the decision maker to analyse and evaluate different alternatives and monitor their impact on different actors during the decision-making process...
March 5, 2018: Mathematical Biosciences
Florian Dams, Javier Leonardo Gonzalez Rodriguez, Kei Long Cheung, Ben F M Wijnen, Mickaël Hiligsmann
OBJECTIVES: Several studies, mostly from developed countries, have identified barriers and facilitators with regard to the uptake of health technology assessment (HTA). This study elicited, using best-worst scaling (BWS), what HTA experts in Colombia consider to be the most important barriers and facilitators in the use of HTA, and makes a comparison to results from the Netherlands. METHODS: Two object case surveys (one for barriers, one for facilitators) were conducted among 18 experts (policy makers, health professionals, PhD students, senior HTA-researchers) from Colombia...
March 7, 2018: Journal of Medical Economics
Alison F Smith, Mike Messenger, Peter Hall, Claire Hulme
INTRODUCTION: Numerous factors contribute to uncertainty in test measurement procedures, and this uncertainty can have a significant impact on the downstream clinical utility and cost-effectiveness of testing strategies. Currently, however, there is no clear guidance concerning if or how such factors should be considered within Health Technology Assessments (HTAs) of tests. OBJECTIVE: The aim was to provide an introduction to key concepts in measurement uncertainty for the HTA community and to explore, via systematic review, current methods utilised within HTAs...
March 3, 2018: PharmacoEconomics
David John Mott
No abstract text is available yet for this article.
March 2, 2018: Patient
G E Calabrò, G La Torre, C de Waure, P Villari, A Federici, W Ricciardi, M L Specchia
BACKGROUND: In an era of a growing economic pressure for all health systems, the interest for "disinvestment" in healthcare increased. In this context, evidence based approaches such as Health Technology Assessment (HTA) are needed both to invest and to disinvest in health technologies. In order to investigate the extent of application of HTA in this field, methodological projects/frameworks, case studies, dissemination initiatives on disinvestment released by HTA agencies and organizations located in Europe were searched...
March 1, 2018: BMC Health Services Research
Joan M Quigley, Juliette C Thompson, Nicholas J Halfpenny, David A Scott
RATIONALE, AIMS, AND OBJECTIVES: When randomized controlled trial data are limited or unavailable, or to supplement randomized controlled trial evidence, health technology assessment (HTA) agencies may rely on systematic reviews of nonrandomized studies (NRSs) for evidence of the effectiveness of health care interventions. NRS designs may introduce considerable bias into systematic reviews, and several methodologies by which to evaluate this risk of bias are available. This study aimed to identify tools commonly used to assess bias in NRS and determine those recommended by HTA bodies...
February 27, 2018: Journal of Evaluation in Clinical Practice
Thomas G Poder, Christian A Bellemare
OBJECTIVES: Contextual data and local expertise are important sources of data that cannot be ignored in hospital-based health technology assessment (HTA) processes. Despite a lack of or unconvincing evidence in the scientific literature, technology can be recommended in a given context. We illustrate this using a case study regarding biplane angiography for vascular neurointervention. METHODS: A systematic literature review was conducted, along with an analysis of the context in our setting...
February 27, 2018: International Journal of Technology Assessment in Health Care
Xukai Zhang, Yi Lei, Hang Yin, Peng Li, Hong Li
Performance-related feedback plays an important role in improving human being's adaptive behavior. Using event-related potentials (ERPs), previous studies have associated a particular component, i.e., reward positivity (RewP), with outcome evaluation processing and found that this component was affected by waiting time before outcome evaluation. Prior research has also suggested that anxious individuals are more prone to detecting threats and susceptible to negative emotions, and show different patterns of brain activity in outcome evaluation...
2018: Frontiers in Human Neuroscience
Kirsten H Herrmann, Ulf Meier-Kriesche, Aljoscha S Neubauer
Introduction: It is discussed whether real world data can be used in health technology assessment. Following it is of interest whether routinely collected data for quality assurance (QA) in the hospital sector is feasible to address epidemiologic questions in kidney transplantation in the AMNOG process in Germany. Objectives: To investigate the proportion of kidney transplants classified as from so-called standard criteria donors (SCD) and from expanded criteria donors (ECD) in Germany and to study the age distribution...
2018: German Medical Science: GMS E-journal
Bahareh Yazdizadeh, Farideh Mohtasham, Ashraf Velayati
BACKGROUND: Following approximately 10 years from the beginning of Iran's national Health Technology Assessment (HTA) programme, the present study aims to evaluate its success by examining the impact of HTA and identifying the determinant factors leading to the implementation of HTA report results. METHODS: The triangulation method was employed herein. HTA reports were initially identified and their impact and determinant factors were then examined from the perspectives of both researchers (by preparing a questionnaire according to the Payback model and sending it to HTA principle investigators) and stakeholders (semi-structured interviews held with each HTA stakeholder)...
February 22, 2018: Health Research Policy and Systems
André Soares Santos, Augusto Afonso Guerra-Junior, Brian Godman, Alec Morton, Cristina Mariano Ruas
INTRODUCTION: Cost-effectiveness thresholds (CETs) are used to judge if an intervention represents sufficient value for money to merit adoption in healthcare systems. The study was motivated by the Brazilian context of HTA, where meetings are being conducted to decide on the definition of a threshold. AREAS COVERED: An electronic search was conducted on Medline (via PubMed), Lilacs (via BVS) and ScienceDirect followed by a complementary search of references of included studies, Google Scholar and conference abstracts...
February 22, 2018: Expert Review of Pharmacoeconomics & Outcomes Research
Christel Rothe Brinkmann, Jesper Falkesgaard Højen, Thomas Aagaard Rasmussen, Anne Sofie Kjær, Rikke Olesen, Paul W Denton, Lars Østergaard, Zhengyu Ouyang, Mathias Lichterfeld, Xu Yu, Ole Schmeltz Søgaard, Charles Dinarello, Martin Tolstrup
Histone deacetylase inhibitors (HDACi) modulate the transcriptional activity of all cells, including innate and adaptive immune cells. Therefore, we aimed to evaluate immunological effects of treatment with the HDACi panobinostat in HIV-infected patients during a clinical phase IIa latency reversal trial. Using flow cytometry, we investigated changes in T cell activation (CD69, CD38, HLA-DR) and the expression of CD39 and CTLA4 on regulatory T cells (Tregs). Whole-blood stimulations were performed and cytokine responses measured using Luminex...
January 2018: MSphere
Andrés Pichon-Riviere, Natalie C Soto, Federico Ariel Augustovski, Sebastián García Martí, Laura Sampietro-Colom
OBJECTIVE: Identify the most relevant, applicable, and priority good practice principles in health technology assessment (HTA) in Latin America, and potential barriers to implementing them in the region. METHODS: HTA good practice principles postulated worldwide were identified and then explored through a deliberative process in a forum of evaluators, funders, and technology producers. RESULTS: Forty-two representatives from ten Latin American countries participated in the forum...
February 19, 2018: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
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