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https://www.readbyqxmd.com/read/28076587/-interventions-to-improve-access-to-health-services-by-indigenous-peoples-in-the-americas
#1
Miguel Araujo, Cecilia Moraga, Evelina Chapman, Jorge Barreto, Eduardo Illanes
Objective: Synthesize evidence on effectiveness of interventions designed to improve access to health services by indigenous populations. Methods: Review of systematic reviews published as of July 2015, selecting and analyzing only studies in the Region of the Americas. The bibliographic search encompassed MEDLINE, Lilacs, SciELO, EMBASE, DARE, HTA, The Cochrane Library, and organization websites. Two independent reviewers selected studies and analyzed their methodological quality...
November 2016: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/28072765/phase-ii-study-of-the-pi3k-inhibitor-bkm120-in-patients-with-advanced-or-recurrent-endometrial-carcinoma-a-stratified-type-i-type-ii-study-from-the-gineco-group
#2
P-E Heudel, M Fabbro, C Roemer-Becuwe, M C Kaminsky, A Arnaud, F Joly, S Roche-Forestier, J Meunier, C Foa, B You, F Priou, Y Tazi, A Floquet, F Selle, D Berton-Rigaud, A Lesoin, E Kalbacher, A Lortholary, L Favier, I Treilleux, I Ray-Coquard
: Backround:Patients with metastatic endometrial carcinoma have a poor prognosis and PIK3CA mutations and amplifications are common in these cancers. This study evaluated the efficacy and safety of the pure PI3K inhibitor BKM120 in advanced or recurrent endometrial carcinoma. METHODS: This phase II, multicentre, single-arm, double strata (histological low grade (LG) or high grade (HG)) open-label study enrolled patients with histologically confirmed advanced or recurrent endometrial carcinoma who had received not more than one prior chemotherapy regimen...
January 10, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28067709/factors-associated-with-risk-of-neurologic-complications-after-peripheral-nerve-blocks-a-systematic-review
#3
Rakesh V Sondekoppam, Ban C H Tsui
The onset of neurologic complications after regional anesthesia is a complex process and may result from an interaction of host, agent, and environmental risk factors. The purpose of this systematic review was examine the qualitative evidence relating to various risk factors implicated in neurologic dysfunction after peripheral nerve block (PNB). The MEDLINE, OVID, and EMBASE databases were primary sources for literature. Cochrane, LILACS, DARE, IndMed, ERIC, NHS, and HTA via Centre for Reviews and Dissemination (CRD; York University) databases were searched for additional unique results...
January 5, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28062129/-methodological-guideline-for-the-efficacy-and-safety-assessment-of-new-pharmaceuticals-implementation-of-eunethta-s-recommendations
#4
Ruth Ubago Pérez, María Auxiliadora Castillo Muñoz, Mercedes Galván Banqueri, Raúl García Estepa, Eva Rocío Alfaro Lara, María Dolores Vega Coca, Carmen Beltrán Calvo, Teresa Molina López
The European network for Health Technology Assessment (EUnetHTA) is the network of public health technology assessment (HTA) agencies and entities from across the EU. In this context, the HTA Core Model(®), has been developed. The Andalusian Agency for Health Technology Assessment (AETSA) is a member of the Spanish HTA Network and EUnetHTA collaboration In addition, AETSA participates in the new EUnetHTA Joint Action 3 (JA, 2016-2019). Furthermore, AETSA works on pharmaceutical assessments. Part of this work involves drafting therapeutic positioning reports (TPRs) on drugs that have recently been granted marketing authorisation, which is overseen by the Spanish Agency of Medicines and Medical Devices (AEMPS)...
January 3, 2017: Gaceta Sanitaria
https://www.readbyqxmd.com/read/28060976/-cardiovascular-recovery-during-intermittent-exercise-in-highly-adherent-partic-pants-with-hypertension-and-type-2-diabetes-mellitus
#5
Johnattan Cano-Montoya, Cristian Álvarez, Cristian Martínez, Andrés Salas, Farid Sade, Rodrigo Ramírez-Campillo
BACKGROUND: Despite the evidence supporting metabolic benefits of high intensity interval exercise (HIIT), there is little information about the cardiovascular response to this type of exercise in patients with type 2 diabetes (T2D) and hypertension (HTA). AIM: To analyze the changes in heart rate at rest, at the onset and at the end of each interval of training, after twelve weeks of a HIIT program in T2D and HTA patients. MATERIAL AND METHODS: Twenty-three participants with T2D and HTA (20 women) participated in a controlled HIIT program...
September 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/28060453/model-based-economic-evaluations-in-smoking-cessation-and-their-transferability-to-new-contexts-a-systematic-review
#6
REVIEW
Marrit L Berg, Kei Long Cheung, Mickaël Hiligsmann, Silvia Evers, Reina J A de Kinderen, Puttarin Kulchaitanaroaj, Subhash Pokhrel
AIMS: To identify different types of models used in economic evaluations of smoking cessation, analyse the quality of the included models examining their attributes and ascertain their transferability to a new context. METHODS: A systematic review of the literature on the economic evaluation of smoking cessation interventions published between 1996 and April 2015, identified via Medline, EMBASE, NHS EED, and HTA. Checklist-based quality of the included studies and transferability scores were based on European Network of Health Economic Evaluation Databases (EURONHEED) criteria...
January 6, 2017: Addiction
https://www.readbyqxmd.com/read/28057183/immunoth%C3%A3-rapie-une-innovation-de-rupture-non-soutenable-%C3%A3-conomiquement
#7
Jean-Pierre Thierry
A NON-SUSTAINABLE BREAKTHROUGH?: The arrival of new immunotherapy anticancer drugs on the market marks a turning point. Their reference prices are fixed in the US and are positioned at the same level that the anticancer targeted therapies. They benefit from an accelerated approval process and often obtain the status of orphan drugs. The extensions of indications to many cancers and the likely combinations could significantly increase healthcare spending at a level that recently unveiled their non-sustainability, due to unrealistic prices approved by regulators...
November 2016: Bulletin du Cancer
https://www.readbyqxmd.com/read/28035842/clinical-and-cost-implications-of-beta-amyloid-detection-with-a%C3%AE-pet-imaging-in-early-alzheimer-s-disease-the-case-of-florbetapir
#8
John Hornberger, Jay Bae, Ian Watson, Joe Johnston, Michael Happich
OBJECTIVE: Amyloid-β (Aβ) positron emission tomography (PET) imaging helps estimate Aβ neuritic plaque density in patients with cognitive impairment who are under evaluation for Alzheimer's disease (AD). This study aims to evaluate the cost-effectiveness of the Aβ-PET scan as an adjunct to standard diagnostic assessment for diagnosis of AD in France, using florbetapir as an example. METHODS: A state-transition probability analysis was developed adopting the French Health Technology Assessment (HTA) perspective per guidance...
December 30, 2016: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28033447/assessment-of-overall-survival-quality-of-life-and-safety-benefits-associated-with-new-cancer-medicines
#9
Sebastian Salas-Vega, Othon Iliopoulos, Elias Mossialos
Importance: There is a dearth of evidence examining the impact of newly licensed cancer medicines on therapy. This information could otherwise support clinical practice, and promote value-based decision-making in the cancer drug market. Objective: To evaluate the comparative therapeutic value of all new cancer medicines approved by the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA) between 2003 and 2013. Design, Setting, and Participants: We used a narrative synthesis approach to systematically synthesize and analyze English, French, and Australian health technology assessments (HTAs) of all new cancer medicines licensed in the United States and Europe between 2003 and 2013...
December 29, 2016: JAMA Oncology
https://www.readbyqxmd.com/read/28032873/el-uso-de-abreviaturas-no-recomendadas-en-el-informe-de-alta-y-prescripci%C3%A3-n-m%C3%A3-dica-estudio-observacional-retrospectivo
#10
F Soto-Arnáez, T Sebastián-Viana, P Carrasco-Garrido, C Fernández-de Las Peñas, D Palacios-Ceña
Fundamento. La historia clínica es la transcripción del relato patográfico del paciente. Los objetivos de este trabajo fueron: identificar las abreviaturas más frecuentes presentes en la historia clínica, identificar las abreviaturas desaconsejadas, identificar abreviaturas polisémicas, y describir su distribución según servicio (médico-quirúrgico).Material y métodos. Estudio observacional, descriptivo y retrospectivo mediante auditoría de historia clínica digitalizada de pacientes dados de alta del hospital Universitario Fuenlabrada en el año 2013...
December 30, 2016: Anales del Sistema Sanitario de Navarra
https://www.readbyqxmd.com/read/28029334/patient-reported-outcomes-in-rare-lysosomal-storage-diseases-key-informant-interviews-and-a-systematic-review-protocol
#11
Patricia A Miller, Sohail M Mulla, Thomasin Adams-Webber, Yasmin Sivji, Gordon H Guyatt, Bradley C Johnston
OBJECTIVES: To investigate the use, challenges and opportunities associated with using patient-reported outcomes (PROs) in studies with patients with rare lysosomal storage diseases (LSDs), we conducted interviews with researchers and health technology assessment (HTA) experts, and developed the methods for a systematic review of the literature. The purpose of the review is to identify the psychometrically sound generic and disease-specific PROs used in studies with patients with five LSDs of interest: Fabry, Gaucher (Type I), Niemann-Pick (Type B) and Pompe diseases, and mucopolysaccharidosis (Types I and II)...
December 28, 2016: International Journal of Technology Assessment in Health Care
https://www.readbyqxmd.com/read/28026877/school-based-education-programmes-for-the-prevention-of-unintentional-injuries-in-children-and-young-people
#12
REVIEW
Elizabeth Orton, Jessica Whitehead, Jacqueline Mhizha-Murira, Mandy Clarkson, Michael C Watson, Caroline A Mulvaney, Joy Ul Staniforth, Munish Bhuchar, Denise Kendrick
BACKGROUND: Unintentional injuries are the leading cause of death in children aged four to 18 years and are a major cause of ill health. The school setting offers the opportunity to deliver preventive interventions to a large number of children and has been used to address a range of public health problems. However, the effectiveness of the school setting for the prevention of different injury mechanisms in school-aged children is not well understood. OBJECTIVES: To assess the effects of school-based educational programmes for the prevention of injuries in children and evaluate their impact on improving children's safety skills, behaviour and practices, and knowledge, and assess their cost-effectiveness...
December 27, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28026076/ethical-issues-with-colorectal-cancer-screening-a-systematic-review
#13
Bjørn Hofmann
RATIONALE, AIMS, AND OBJECTIVES: Colorectal cancer (CRC) screening is widely recommended and implemented. However, sometimes CRC screening is not implemented despite good evidence, and some types of CRC screening are implemented despite lack of evidence. The objective of this article is to expose and elucidate relevant ethical issues in the literature on CRC screening that are important for open and transparent deliberation on CRC screening. METHODS: An axiological question-based method is used for exposing and elucidating ethical issues relevant in HTA...
December 27, 2016: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/28025325/developing-a-decision-support-system-to-link-health-technology-assessment-hta-reports-to-the-health-system-policies-in-iran
#14
Shahram Yazdani, Mohammad-Pooyan Jadidfard
The recent increase of 'Health Technology Assessment' (HTA)-related activities in Iran has necessitated the clarification of policy-making process based on the HTA reports. This study aimed to develop a Decision Support System (DSS) in order to adopt evidence-informed policies regarding health technologies in Iran. The study can be classified as Health Policy and Systems Research. A core panel of seven experts conducted two separate reviews of relevant literature for: 1- Determining the potential technology-related policies...
December 26, 2016: Health Policy and Planning
https://www.readbyqxmd.com/read/28013109/the-impact-of-hta-and-procurement-practices-on-the-selection-and-prices-of-medical-devices
#15
Giuditta Callea, Patrizio Armeni, Marta Marsilio, Claudio Jommi, Rosanna Tarricone
Technological innovation in healthcare yields better health outcomes but also drives healthcare expenditure, and governments are struggling to maintain an appropriate balance between patient access to modern care and the economic sustainability of healthcare systems. Health Technology Assessment (HTA) and centralized procurement are increasingly used to govern the introduction and diffusion of new technologies in an effort to make access to innovation financially sustainable. However, little empirical evidence is available to determine how they affect the selection of new technologies and unit prices...
November 29, 2016: Social Science & Medicine
https://www.readbyqxmd.com/read/28012316/the-effect-of-trimethylamine-n-oxide-on-helicobacter-pylori-induced-changes-of-immunoinflammatory-genes-expression-in-gastric-epithelial-cells
#16
Daoyan Wu, Mei Cao, Jingshan Peng, Ningzhe Li, Sijun Yi, Liju Song, Xuege Wang, Mao Zhang, Jian Zhao
Colonization of Helicobacter pylori (H. pylori) induces immune and inflammatory response in gastric mucosa. Trimethylamine N-oxide (TMAO), from diet and metabolite through the action of gut microbiota, has been linked to inflammatory diseases. To investigate the effects of TMAO and H. pylori infection on gene expression in gastric epithelial cells, Human gene chip Affymetrix HTA 2.0 was used in this study. 1312 genes were identified as differentially expressed genes in GES-1 cells with H. pylori and TMAO co-treatment compared to the control...
February 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28008235/importance-of-hemodialysis-related-outcomes-comparison-of-ratings-by-a-self-help-group-clinicians-and-health-technology-assessment-authors-with-those-by-a-large-reference-group-of-patients
#17
Inger M Janssen, Fueloep Scheibler, Ansgar Gerhardus
BACKGROUND: The selection of important outcomes is a crucial decision for clinical research and health technology assessment (HTA), and there is ongoing debate about which stakeholders should be involved. Hemodialysis is a complex treatment for chronic kidney disease (CKD) and affects many outcomes. Apart from obvious outcomes, such as mortality, morbidity and health-related quality of life (HRQoL), others such as, concerning daily living or health care provision, may also be important...
2016: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28005541/fair-processes-for-priority-setting-putting-theory-into-practice-comment-on-expanded-hta-enhancing-fairness-and-legitimacy
#18
Maarten P Jansen, Jan-Kees Helderman, Bert Boer, Rob Baltussen
Embedding health technology assessment (HTA) in a fair process has great potential to capture societal values relevant to public reimbursement decisions on health technologies. However, the development of such processes for priority setting has largely been theoretical. In this paper, we provide further practical lead ways on how these processes can be implemented. We first present the misconception about the relation between facts and values that is since long misleading the conduct of HTA and underlies the current assessment-appraisal split...
July 3, 2016: International Journal of Health Policy and Management
https://www.readbyqxmd.com/read/28005003/pleasant-preventing-and-lessening-exacerbations-of-asthma-in-school-age-children-associated-with-a-new-term-a-cluster-randomised-controlled-trial-and-economic-evaluation
#19
Steven A Julious, Michelle J Horspool, Sarah Davis, Mike Bradburn, Paul Norman, Neil Shephard, Cindy L Cooper, W Henry Smithson, Jonathan Boote, Heather Elphick, Amanda Loban, Matthew Franklin, Wei Sun Kua, Robin May, Jennifer Campbell, Rachael Williams, Saleema Rex, Oscar Bortolami
BACKGROUND: Asthma episodes and deaths are known to be seasonal. A number of reports have shown peaks in asthma episodes in school-aged children associated with the return to school following the summer vacation. A fall in prescription collection in the month of August has been observed, and was associated with an increase in the number of unscheduled contacts after the return to school in September. OBJECTIVE: The primary objective of the study was to assess whether or not a NHS-delivered public health intervention reduces the September peak in unscheduled medical contacts...
December 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28000158/a-systematic-review-and-critical-appraisal-of-economic-evaluations-of-pharmacological-interventions-for-people-with-bipolar-disorder
#20
REVIEW
Ifigeneia Mavranezouli, Joran Lokkerbol
BACKGROUND: Bipolar disorder (BD) is a chronic mood disorder that causes substantial psychological and financial burden. Various pharmacological treatments are effective in the management and prevention of acute episodes of BD. In an era of tighter healthcare budgets and a need for more efficient use of resources, several economic evaluations have evaluated the cost effectiveness of treatments for BD. OBJECTIVE: The aim of this study was to systematically review and appraise published economic evaluations of pharmacological interventions for BD...
December 20, 2016: PharmacoEconomics
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