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https://www.readbyqxmd.com/read/28649038/multiple-spectroscopic-analyses-reveal-the-fate-and-metabolism-of-sulfamide-herbicide-triafamone-in-agricultural-environments
#1
Mengcen Wang, Yuan Qian, Xiaoyu Liu, Peng Wei, Man Deng, Lei Wang, Huiming Wu, Guonian Zhu
Triafamone, a sulfamide herbicide, has been extensively utilized for weed control in rice paddies in Asia. However, its fate and transformation in the environment have not been established. Through a rice paddy microcosm-based simulation trial combined with multiple spectroscopic analyses, we isolated and identified three novel metabolites of triafamone, including hydroxyl triafamone (HTA), hydroxyl triafamone glycoside (HTAG), and oxazolidinedione triafamone (OTA). When triafamone was applied to rice paddies at a concentration of 34...
June 22, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28641608/hospital-based-health-technology-assessment-in-brazil-an-overview-of-the-initial-experiences
#2
Claudia Cristina de Aguiar Pereira, Renata Dos Santos Rabello, Flávia Tavares Silva Elias
OBJECTIVES: Hospital-based health technology assessment (HTA) has become increasingly important in Brazil due to its strategic importance to promote adoption, incorporation, dissemination, and disinvestment of technologies. A strategy to foster hospital-based HTA was implemented in 2009 by creating hospital-based HTA nuclei (NATS) at university hospitals and other strategic hospitals. METHODS: Between 2011 and 2012, we interviewed board members in twenty-three NATS located in all geographic regions of Brazil to assess their general characteristics, scientific output, and challenges...
June 23, 2017: International Journal of Technology Assessment in Health Care
https://www.readbyqxmd.com/read/28634601/an-annealing-free-aqueous-processed-anatase-tio2-compact-layer-for-efficient-planar-heterojunction-perovskite-solar-cells
#3
Chengwu Yang, Mingyu Yu, Dichun Chen, Yaqing Zhou, Wei Wang, Yang Li, Tung-Chun Lee, Daqin Yun
A facile aqueous-based fabrication scheme is developed for producing annealing-free anatase TiO2 (AF-TiO2) films that exhibit efficient electron transport properties in planar heterojunction perovskite solar cells (PSCs). AF-TiO2 films are fabricated by spin coating on a substrate a colloidal solution of anatase TiO2 nanoparticles (NPs) prepared via a low temperature hydrolytic sol-gel method. The resultant AF-TiO2 films show low electrical resistance, high transmittance in the visible and near-infrared regions and facilitation of high-quality perovskite film formation, which can be attributed to their homogeneous surface morphology and nanocrystallinity...
June 21, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28629473/emergency-treatment-with-levetiracetam-or-phenytoin-in-status-epilepticus-in-children-the-eclipse-study-study-protocol-for-a-randomised-controlled-trial
#4
Mark D Lyttle, Carrol Gamble, Shrouk Messahel, Helen Hickey, Anand Iyer, Kerry Woolfall, Amy Humphreys, Naomi E A Bacon, Louise Roper, Franz E Babl, Stuart R Dalziel, Mary Ryan, Richard E Appleton
BACKGROUND: Convulsive status epilepticus (CSE) is the most common life-threatening neurological emergency in childhood. These children are also at risk of significant morbidity, with acute and chronic impact on the family and the health and social care systems. The current recommended first-choice, second-line treatment in children aged 6 months and above is intravenous phenytoin (fosphenytoin in the USA), although there is a lack of evidence for its use and it is associated with significant side effects...
June 19, 2017: Trials
https://www.readbyqxmd.com/read/28628932/-european-collaboration-in-medical-device-assessment-one-step-towards-cross-border-health-care
#5
Julia Mayer, Sabine Ettinger, Anna Nachtnebel
Aim The aim of this paper was to present the legal framework as well as previous experience in transnational collaboration regarding the assessment of medical devices for reimbursement decisions. Furthermore, the possible benefit of transnational collaboration for various stakeholders will be discussed. Methods Experiences gathered with the compilation of overall 6 joint rapid assessments of medical devices within the completed European Network for Health Technology Assessment (EUnetHTA) Joint Action 2 (JA2) are summarised and discussed...
June 19, 2017: Das Gesundheitswesen
https://www.readbyqxmd.com/read/28616775/informing-reimbursement-decisions-using-cost-effectiveness-modelling-a-guide-to-the-process-of-generating-elicited-priors-to-capture-model-uncertainties
#6
Laura Bojke, Bogdan Grigore, Dina Jankovic, Jaime Peters, Marta Soares, Ken Stein
In informing decisions, utilising health technology assessment (HTA), expert elicitation can provide valuable information, particularly where there is a less-developed evidence-base at the point of market access. In these circumstances, formal methods to elicit expert judgements are preferred to improve the accountability and transparency of the decision-making process, help reduce bias and the use of heuristics, and also provide a structure that allows uncertainty to be expressed. Expert elicitation is the process of transforming the subjective and implicit knowledge of experts into their quantifiable expressions...
June 15, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/28614470/-health-technology-assessment-in-ecuador-s-ministry-of-public-health-as-a-tool-for-drug-purchasing-from-2012-to-2015
#7
Luciana Armijos, Santiago Escalante, Tatiana Villacrés
Objective: Learn how the Ministry of Public Health (MSP, the Spanish acronym) of Ecuador uses health technology assessment (HTA) in decision-making on the purchase of drugs that are not on the National List of Essential Medicines (NLEM). Methods: Information from databases of the Health Intelligence Directorate (DIS, the Spanish acronym) and the National Directorate of Drugs and Medical Devices (DNMDM, the Spanish acronym), was used to compare decisions made by both entities, to learn about the use and consistency of HTA reports in decisions on purchasing drugs not included in the NLEM...
June 8, 2017: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/28614463/health-technology-assessment-the-process-in-brazil
#8
Fernanda Lessa, Marcos Bosi Ferraz
Objectives: To describe, analyze, and compare the opinions of decisionmakers involved in the health technology assessment (HTA) process in Brazil in 2011. Methods: A cross-sectional study was conducted using a structured questionnaire to evaluate the opinions of a convenience sample of health care professionals from both the public and private health care systems (HCS). The survey collected demographic data for each respondent along with their input on national regulations...
June 8, 2017: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/28595663/visions-of-stakeholders-about-instutionalization-of-health-technology-assessment-in-chile-a-qualitative-study
#9
Constanza Paz Lavín, Rafael Alaniz, Manuel Espinoza
OBJECTIVES: The aim of this study was to explore and describe the viewpoints and beliefs with respect to a health technology assessment (HTA) process and its institutionalization in a sample of stakeholder representatives in Chile. METHODS: A qualitative study with a descriptive design, based on the model of discourse analysis, was performed. Eighteen semi-structured interviews were conducted on nineteen Chilean representatives of stakeholders in HTA. The data analysis was based on a process of open coding that allows the contrasting of the interviewees' visions...
June 9, 2017: International Journal of Technology Assessment in Health Care
https://www.readbyqxmd.com/read/28595660/health-technology-assessment-in-turkey
#10
Rabia Kahveci, Esra Meltem Koç, Emine Özer Küçük
OBJECTIVES: The healthcare transformation program in Turkey has shown its success with improvements in important health indicators, increased access to healthcare services and expansion of coverage to all citizens. Turkey has been relatively able to bear the burdens associated with this due to rapid economic growth. The need for health technology assessment (HTA) was believed as a result of the expansion of coverage, pressure of new technologies, and increased expenditures. This study outlines the background and current formalization of HTA and shares the current use of HTA in decision making, while summarizing the transformation of the Turkish healthcare system for developing a high-quality, equal, and accessible care system...
June 9, 2017: International Journal of Technology Assessment in Health Care
https://www.readbyqxmd.com/read/28587590/rna-sequencing-and-transcriptome-arrays-analyses-show-opposing-results-for-alternative-splicing-in-patient-derived-samples
#11
Petr V Nazarov, Arnaud Muller, Tony Kaoma, Nathalie Nicot, Cristina Maximo, Philippe Birembaut, Nhan L Tran, Gunnar Dittmar, Laurent Vallar
BACKGROUND: RNA sequencing (RNA-seq) and microarrays are two transcriptomics techniques aimed at the quantification of transcribed genes and their isoforms. Here we compare the latest Affymetrix HTA 2.0 microarray with Illumina 2000 RNA-seq for the analysis of patient samples - normal lung epithelium tissue and squamous cell carcinoma lung tumours. Protein coding mRNAs and long non-coding RNAs (lncRNAs) were included in the study. RESULTS: Both platforms performed equally well for protein-coding RNAs, however the stochastic variability was higher for the sequencing data than for microarrays...
June 6, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28582404/drug-class-specific-changes-in-the-volume-and-cost-of-antidiabetic-medications-in-poland-between-2012-and-2015
#12
Andrzej Śliwczyński, Melania Brzozowska, Andrzej Jacyna, Petre Iltchev, Tymoteusz Iwańczuk, Waldemar Wierzba, Michał Marczak, Katarzyna Orlewska, Piotr Szymański, Ewa Orlewska
AIM: to investigate the drug-class-specific changes in the volume and cost of antidiabetic medications in Poland in 2012-2015. METHODS: This retrospective analysis was conducted based on the National Health Fund database covering an entire Polish population. The volume of antidiabetic medications is reported according to ATC/DDD methodology, costs-in current international dollars, based on purchasing power parity. RESULTS: During a 4-year observational period the number of patients, consumption of antidiabetic drugs and costs increased by 17%, 21% and 20%, respectively...
2017: PloS One
https://www.readbyqxmd.com/read/28580892/harmonizing-health-technology-assessment-practices-in-university-hospitals-to-what-extent-is-the-mini-hta-model-suitable-in-the-french-context
#13
Nicolas Martelli, Capucine Devaux, Hélène van den Brink, Mathilde Billaux, Judith Pineau, Patrice Prognon, Isabelle Borget
BACKGROUND: The number of new medical devices for individual use that are launched annually exceeds the assessment capacity of the French national health technology assessment (HTA) agency. This has resulted in hospitals, and particularly university hospitals (UHs), developing hospital-based HTA initiatives to support their decisions for purchasing innovative devices. However, the methodologies used in such hospitals have no common basis. The aim of this study was to assess a mini-HTA model as a potential solution to harmonize HTA methodology in French UHs...
June 5, 2017: International Journal of Technology Assessment in Health Care
https://www.readbyqxmd.com/read/28579103/eldor-detected-nmr-a-general-and-robust-method-for-electron-nuclear-hyperfine-spectroscopy
#14
Nicholas Cox, Anna Nalepa, Wolfgang Lubitz, Anton Savitsky
ELDOR-detected NMR (EDNMR) performed at higher magnetic fields is becoming an increasingly popular alternative to conventional ENDOR for the characterization of electron-nuclear hyperfine interactions owing to its enhanced sensitivity. However there are two key problems that limit its widespread adoption, with factors controlling: (i) lineshape distortions and; (ii) overall spectral resolution, still largely understood only at a qualitative level. Indeed highly anisotropic (dipolar) coupled species are particularly problematic in the EDNMR experiment...
July 2017: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/28578752/technology-assessment-in-hospitals-lessons-learned-from-an-empirical-experiment
#15
Emanuela Foglia, Emanuele Lettieri, Lucrezia Ferrario, Emanuele Porazzi, Elisabetta Garagiola, Roberta Pagani, Marzia Bonfanti, Valentina Lazzarotti, Raffaella Manzini, Cristina Masella, Davide Croce
OBJECTIVES: Hospital Based Health Technology Assessment (HBHTA) practices, to inform decision making at the hospital level, emerged as urgent priority for policy makers, hospital managers, and professionals. The present study crystallized the results achieved by the testing of an original framework for HBHTA, developed within Lombardy Region: the IMPlementation of A Quick hospital-based HTA (IMPAQHTA). The study tested: (i) the HBHTA framework efficiency, (ii) feasibility, (iii) the tool utility and completeness, considering dimensions and sub-dimensions...
June 5, 2017: International Journal of Technology Assessment in Health Care
https://www.readbyqxmd.com/read/28578750/using-the-health-technology-assessment-toolbox-to-facilitate-procurement-the-case-of-smart-pumps-in-a-canadian-hospital
#16
Thomas G Poder
OBJECTIVES: The aim of this study was to present the experience of a Canadian hospital-based health technology assessment (HTA) unit that performed the traditional functions of the HTA process along with many other activities to facilitate the choice of smart pumps. METHODS: A rapid literature review was initiated, but little evidence was found. Moreover, the evidence provided was too far from our hospital context. To help our decision makers, we offered them a list of various services based on the skills of our HTA unit staff...
June 5, 2017: International Journal of Technology Assessment in Health Care
https://www.readbyqxmd.com/read/28578735/developments-in-value-frameworks-to-inform-the-allocation-of-healthcare-resources
#17
Wija Oortwijn, Laura Sampietro-Colom, Fay Habens
BACKGROUND: In recent years, there has been a surge in the development of frameworks to assess the value of different types of health technologies to inform healthcare resource allocation. The reasons for, and the potential of, these value frameworks were discussed during the 2017 Health Technology Assessment International (HTAi) Policy Forum Meeting. METHODS: This study reflects the discussion, drawing on presentations from invited experts and Policy Forum members, as well as a background paper...
June 5, 2017: International Journal of Technology Assessment in Health Care
https://www.readbyqxmd.com/read/28578711/hospital-based-health-technology-assessment-for-the-adoption-of-innovative-medical-devices-within-french-hospitals-opportunities-and-challenges-for-industry
#18
Camille Dutot, Grégoire Mercier, Isabelle Borget, Côme de Sauvebeuf, Nicolas Martelli
OBJECTIVES: Within French university hospitals, some internal committees are in charge of conducting hospital-based health technology assessment (Hb-HTA) to support managerial decisions regarding the adoption of innovations. For manufacturers, hospitals are usually the entry point for new and innovative medical devices, which cannot be accessed without the Hb-HTA committees' approval. Thus, the main objective of this pilot survey was to explore manufacturers' insights into Hb-HTA processes...
June 5, 2017: International Journal of Technology Assessment in Health Care
https://www.readbyqxmd.com/read/28566099/health-technology-assessment-the-scientific-career-of-a-policy-concept
#19
Cyril Benoit, Philippe Gorry
OBJECTIVES: The aim of this work was to provide a comprehensive overview of the evolution of the health technology assessment (HTA) concept in the scientific literature through a scientometric approach. METHODS: A literature search was conducted, by selecting publications, as well as news from the media, containing "health technology assessment" in their title, abstracts, or keywords. We then undertook a bibliometric and network analysis on the corpus of 2,865 publications thus obtained...
June 1, 2017: International Journal of Technology Assessment in Health Care
https://www.readbyqxmd.com/read/28562126/a-systematic-literature-review-of-methods-of-incorporating-mortality-in-cost-effectiveness-analyses-of-lipid-lowering-therapies
#20
Jesse D Ortendahl, Amanda L Harmon, Tanya G K Bentley, Michael S Broder
AIMS: Cost effectiveness analysis (CEA) is a useful tool for estimating the value of an intervention in relation to alternatives. In cardiovascular disease (CVD), CEA is especially important, given the high economic and clinical burden. One key driver of value is CVD mortality prevention. However, data used to inform CEA parameters can be limited, given the difficulty in demonstrating statistically significant mortality benefit in randomized clinical trials (RCTs), due in part to the frequency of fatal events and limited trial durations...
July 2017: Journal of Medical Economics
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