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https://www.readbyqxmd.com/read/29137679/trial-of-acute-femoral-fracture-fixation-traffix-study-protocol-for-a-randomised-controlled-feasibility-trial
#1
Xavier L Griffin, Matthew L Costa, Juul Achten, Melina Dritsaki, Janis Baird, Nicholas Parsons
BACKGROUND: Distal femoral fractures are a source of considerable morbidity and best treatment is currently uncertain. The Trial of Acute Femoral Fracture Fixation (TrAFFix) is a randomised, parallel-group feasibility study designed to inform the design of a later, definitive clinical trial comparing intramedullary nails and locking plates for the treatment of distal femoral fractures. METHODS/DESIGN: Patients aged 50 years and older with a femoral fracture within the distal two Müller squares are potentially eligible for inclusion...
November 14, 2017: Trials
https://www.readbyqxmd.com/read/29124632/revealed-and-stated-preferences-of-decision-makers-for-priority-setting-in-health-technology-assessment-a-systematic-review
#2
REVIEW
Peter Ghijben, Yuanyuan Gu, Emily Lancsar, Silva Zavarsek
BACKGROUND: There is much interest from stakeholders in understanding how health technology assessment (HTA) committees make national funding decisions for health technologies. A growing literature has analysed past decisions by committees (revealed preference, RP studies) and hypothetical decisions by committee members (stated preference, SP studies) to identify factors influencing decisions and assess their importance. OBJECTIVES: A systematic review of the literature was undertaken to provide insight into committee preferences for these factors (after controlling for other factors) and the methods used to elicit them...
November 9, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/29122048/evaluation-of-patient-and-public-involvement-initiatives-in-health-technology-assessment-a-survey-of-international-agencies
#3
Laura Weeks, Julie Polisena, Anna Mae Scott, Anke-Peggy Holtorf, Sophie Staniszewska, Karen Facey
OBJECTIVES: Although there is increased awareness of patient and public involvement (PPI) among health technology assessment (HTA) organizations, evaluations of PPI initiatives are relatively scarce. Our objective as members of Health Technology Assessment International's (HTAi's) Patient and Citizen Involvement Group (PCIG) was to advance understanding of the range of evaluation strategies adopted by HTA organizations and their potential usefulness. METHODS: In March 2016, a survey was sent to fifty-four HTA organizations through the International Network of Agencies for Health Technology Assessment (INAHTA) and contacts of members of HTAi's PCIG...
November 10, 2017: International Journal of Technology Assessment in Health Care
https://www.readbyqxmd.com/read/29119177/physiological-linkage-of-gender-bioavailable-hydroxytyrosol-derivatives-and-their-metabolites-with-systemic-catecholamine-metabolism
#4
R Domínguez-Perles, D Auñón, F Ferreres, A Gil-Izquierdo
Despite extensive characterization of hydroxytyrosol (HT), there is a gap in the knowledge about its capacity to modulate catecholamine pathways. This study deals with the evaluation of the effects of HT, hydroxytyrosol acetate (HTA), and 3,4-dihydroxyphenylacetic acid (DOPAC), as well as their microbial metabolites (homovanillyl alcohol and tyrosol), on the excretion of catecholamines by UHPLC-ESI-QqQ-MS/MS upon administration at 1 and 5 mg kg(-1) to male and female rats. The evaluation of urinary dopamine, norepinephrine, normetanephrine, and 3-methoxytyramine demonstrated 12...
November 9, 2017: Food & Function
https://www.readbyqxmd.com/read/29113611/the-added-value-of-integrate-hta-guidance-in-the-work-processes-of-health-technology-assessment-agencies
#5
Gert Jan van der Wilt, Wietske Kievit, Wija Oortwijn
A central idea underlying the INTEGRATE-HTA project is that many of the interventions that are being used in health care are quite complex. By this, we mean that the relation between the delivery of the intervention on the one hand, and the onset of (desired and undesired) changes may be less straightforward than hoped for. There may be all sorts of reasons for this, varying from a lack of resources, lack of skills, perverse incentives, organizational problems, etc. Not identifying such factors and their potential impact may seriously compromise the policy relevance of a health technology assessment (HTA) (1)...
November 8, 2017: International Journal of Technology Assessment in Health Care
https://www.readbyqxmd.com/read/29108525/who-s-afraid-of-institutionalizing-health-technology-assessment-hta-interests-and-policy-positions-on-hta-in-the-czech-republic
#6
Olga Löblová
This article identifies the interests and policy positions of key health policy stakeholders regarding the creation of a health technology assessment (HTA) agency in the Czech Republic, and what considerations influenced them. Vested interests have been suggested as a factor mitigating the diffusion of HTA bodies internationally. The Czech Republic recently considered and discarded establishing an HTA agency, making it a good case for studying actors' policy positions throughout the policy debates. Findings are based on in-depth, semi-structured expert and elite interviews with 34 key Czech health policy actors, supported by document analysis and extensive triangulation...
November 7, 2017: Health Economics, Policy, and Law
https://www.readbyqxmd.com/read/29103380/integrate-hta-a-low-and-middle-income-country-perspective
#7
Leon Bijlmakers, Debjani Mueller, Rabia Kahveci, Yingyao Chen, Gert Jan van der Wilt
OBJECTIVES: The INTEGRATE-HTA project recommends that complexity be taken into account when conducting health technology assessments (HTAs) and suggests a five-step process for doing that. This study examines whether the approach suggested by INTEGRATE-HTA could be useful, appropriate, and feasible in the context of low- and middle-income countries (LMIC) given some of the typical challenges that healthcare systems face in those countries. METHODS: A nonexhaustive literature review was performed on the implementation in low and middle income countries of the five aspects recommended by the INTEGRATE-HTA project, using the following search terms: national health planning, health sector strategy, health sector performance, assessment criteria, health (management) information, complexity, context, stakeholder consultation...
November 6, 2017: International Journal of Technology Assessment in Health Care
https://www.readbyqxmd.com/read/29100909/trait-anxiety-and-probabilistic-learning-behavioral-and-electrophysiological-findings
#8
Donghong Jiang, Dandan Zhang, Yuming Chen, Zhenhong He, Qiufeng Gao, Ruolei Gu, Pengfei Xu
Anxiety is a negative emotion that affects various aspects of people's daily life. To explain why individuals with high anxiety tend to make suboptimal decisions, we suggest that their learning ability might play an important role. Regarding that anxiety modulates both outcome expectation and attention allocation, it is reasonable to hypothesize that the function of feedback learning should be sensitive to individual level of anxiety. However, previous studies that directly examined this hypothesis were scarce...
October 31, 2017: Biological Psychology
https://www.readbyqxmd.com/read/29095135/hta-in-central-eastern-southern-europe-finding-its-way-to-health-policy
#9
Anna Zawada, Marjukka Mäkelä
The number of publications on health technology assessment (HTA) from Central, Eastern, and Southern Europe (CESE countries) is still low compared with the north and west of Europe. It is not surprising, as the idea of HTA originated from high-income Western economies and was afterward adopted by the south-eastern part of Europe, which mostly consists of middle-income countries. These CESE countries, with less capacity and experience with HTA processes, must deal with even tougher decisions on financing health technologies than north-western Europe...
January 2017: International Journal of Technology Assessment in Health Care
https://www.readbyqxmd.com/read/29091169/-multi-criteria-decision-analysis-for-health-technology-resource-allocation-and-assessment-so-far-and-so-near
#10
Alessandro Gonçalves Campolina, Patrícia Coelho De Soárez, Fábio Vieira do Amaral, Jair Minoro Abe
Multi-criteria decision analysis (MCDA) is an emerging tool that allows the integration of relevant factors for health technology assessment (HTA). This study aims to present a summary of the methodological characteristics of MCDA: definitions, approaches, applications, and implementation stages. A case study was conducted in the São Paulo State Cancer Institute (ICESP) in order to understand the perspectives of decision-makers in the process of drafting a recommendation for the incorporation of technology in the Brazilian Unified National Health System (SUS), through a report by the Brazilian National Commission for the Incorporation of Technologies in the SUS (CONITEC)...
October 26, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/29081919/utilization-of-multiple-criteria-decision-analysis-mcda-to-support-healthcare-decision-making-fifarma-2016
#11
Julia I Drake, Juan Carlos Trujillo de Hart, Clara Monleón, Walter Toro, Joice Valentim
Background and objectives:   MCDA is a decision-making tool with increasing use in the healthcare sector, including HTA (Health Technology Assessment). By applying multiple criteria, including innovation, in a comprehensive, structured and explicit manner, MCDA fosters a transparent, participative, consistent decision-making process taking into consideration values of all stakeholders. This paper by FIFARMA (Latin American Federation of Pharmaceutical Industry) proposes the deliberative (partial) MCDA as a more pragmatic, agile approach, especially when newly implemented...
2017: Journal of Market Access & Health Policy
https://www.readbyqxmd.com/read/29073981/applying-multi-criteria-decision-analysis-mcda-simple-scoring-as-an-evidence-based-hta-methodology-for-evaluating-off-patent-pharmaceuticals-opps-in-emerging-markets
#12
Diana Brixner, Nikos Maniadakis, Zoltán Kaló, Shanlian Hu, Jie Shen, Kalman Wijaya
Off-patent pharmaceuticals (OPPs) represent more than 60% of the pharmaceutical market in many emerging countries, where they are frequently evaluated primarily on cost rather than with health technology assessment. OPPs are assumed to be identical to the originators. Branded and unbranded generic versions can, however, vary from the originator in active pharmaceutical ingredients, dosage, consistency formulation, excipients, manufacturing processes, and distribution, for example. These variables can alter the efficacy and safety of the product, negatively impacting both the anticipated cost savings and the population's health...
September 2017: Value in Health Regional Issues
https://www.readbyqxmd.com/read/29073892/multiple-criteria-decision-analysis-in-the-context-of-health-technology-assessment-a-simulation-exercise-on-metastatic-colorectal-cancer-with-multiple-stakeholders-in-the-english-setting
#13
Aris Angelis, Gilberto Montibeller, Daniel Hochhauser, Panos Kanavos
BACKGROUND: Multiple criteria decision analysis (MCDA) has appeared as a methodology to address limitations of economic evaluation in health technology assessment (HTA), however there are limited empirical evidence from real world applications. The aim of this study is to test in practice a recently developed MCDA methodological framework known as Advance Value Framework (AVF) through a proof-of-concept case study engaging multiple stakeholders. METHODS: A multi-attribute value theory methodological process was adopted involving problem structuring, model building, model assessment and model appraisal phases...
October 26, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/29065947/taking-patient-heterogeneity-and-preferences-into-account-in-health-technology-assessments
#14
Wietske Kievit, Marcia Tummers, Ralph van Hoorn, Andrew Booth, Kati Mozygemba, Pietro Refolo, Dario Sacchini, Lisa Pfadenhauer, Ansgar Gerhardus, Gert Jan Van der Wilt
OBJECTIVES: The INTEGRATE-HTA project provided methodology to evaluate complex technologies. This study provides guidance on how to retrieve and critically appraise available evidence on moderators and predictors of treatment effects and on patient preferences for treatment outcomes as a source of complexity. METHODS: Search filters for PubMed were developed by hand-searching a large volume of articles reporting on relevant aspects. Search terms were retrieved from selected papers and algorithmically combined to find the optimal combination of search terms...
October 25, 2017: International Journal of Technology Assessment in Health Care
https://www.readbyqxmd.com/read/29062528/strengthening-international-patient-advocacy-perspectives-on-patient-involvement-in-hta-within-the-htai-patient-and-citizen-involvement-interest-group-commentary
#15
EDITORIAL
Janet L Wale, Anna Mae Scott, Neil Bertelsen, Nick Meade
PLAIN LANGUAGE SUMMARY: Health Technology Assessment (HTA) is an evidence-based decision-making process, focusing on evaluating health technologies for funding within a healthcare system. 'Health technologies' include medications, medical devices, diagnostics, medical procedures and services. Health Technology Assessment international (HTAi) is a global society for those who produce, use, participate in, or encounter HTA. The HTAi Secretariat supports special interest groups within HTAi...
2017: Res Involv Engagem
https://www.readbyqxmd.com/read/29062527/patient-advocate-perspectives-on-involvement-in-hta-an-international-snapshot
#16
Anna Mae Scott, Janet L Wale
PLAIN ENGLISH SUMMARY: A number of health technology assessment (HTA) organisations have developed processes to engage patients in the assessment of new health technologies such as pharmaceuticals, diagnostic tests, devices or medical procedures. Typically, this involves the HTA agency providing an opportunity for patient advocates and their patient organisations (support groups for patients with a specific disease or condition) to provide submissions detailing experiences with the disease and the health technology that is being assessed...
2017: Res Involv Engagem
https://www.readbyqxmd.com/read/29058478/improving-the-quality-of-discrete-choice-experiments-in-health-how-can-we-assess-validity-and-reliability
#17
Ellen M Janssen, Deborah A Marshall, A Brett Hauber, John F P Bridges
The recent endorsement of discrete-choice experiments (DCEs) and other stated-preference methods by regulatory and health technology assessment (HTA) agencies has placed a greater focus on demonstrating the validity and reliability of preference results. Areas covered: We present a practical overview of tests of validity and reliability that have been applied in the health DCE literature and explore other study qualities of DCEs. From the published literature, we identify a variety of methods to assess the validity and reliability of DCEs...
October 23, 2017: Expert Review of Pharmacoeconomics & Outcomes Research
https://www.readbyqxmd.com/read/29056910/the-early-awareness-and-alert-system-in-sweden-history-and-current-status
#18
REVIEW
Irene Eriksson, Björn Wettermark, Marie Persson, Morgan Edström, Brian Godman, Anna Lindhé, Rickard E Malmström, Helena Ramström, Mia von Euler, Anna Bergkvist Christensen
Introduction: Over the past decades, early awareness and alert (EAA) activities and systems have gained importance and become a key early health technology assessment (HTA) tool. While a pioneer in HTA, Sweden had no national level EAA activities until 2010. We describe the evolution and current status of the Swedish EAA System. Methods: This was a historical analysis based on the knowledge and experience of the authors supplemented by a targeted review of published and gray literature as well as documents relating to EAA activities in Sweden...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29052164/the-role-of-condition-specific-preference-based-measures-in-health-technology-assessment
#19
REVIEW
Donna Rowen, John Brazier, Roberta Ara, Ismail Azzabi Zouraq
A condition-specific preference-based measure (CSPBM) is a measure of health-related quality of life (HRQOL) that is specific to a certain condition or disease and that can be used to obtain the quality adjustment weight of the quality-adjusted life-year (QALY) for use in economic models. This article provides an overview of the role and the development of CSPBMs, and presents a description of existing CSPBMs in the literature. The article also provides an overview of the psychometric properties of CSPBMs in comparison with generic preference-based measures (generic PBMs), and considers the advantages and disadvantages of CSPBMs in comparison with generic PBMs...
October 19, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/29052162/international-regulations-and-recommendations-for-utility-data-for-health-technology-assessment
#20
REVIEW
Donna Rowen, Ismail Azzabi Zouraq, Helene Chevrou-Severac, Ben van Hout
Recommendations and guidelines for the collection, generation, source and usage of utility data for health technology assessment (HTA) vary across different countries, with no international consensus. Many international agencies generate their own guidelines providing details on their preferred methods for HTA submissions, and there is variability in both what they recommend and the clarity and amount of detail provided in their guidelines. This article provides an overview of international regulations and recommendations for utility data in HTA for a selection of key HTA countries: Australia, Canada, France, Germany, the Netherlands, Spain (Catalonia), Sweden and the UK (England/Wales and Scotland)...
October 19, 2017: PharmacoEconomics
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