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Sabina Sanghera, Joanna Coast, Richard M Martin, Jenny L Donovan, Syed Mohiuddin
BACKGROUND: There is ongoing debate about the harms and benefits of a national prostate cancer screening programme. Several model-based cost-effectiveness analyses have been developed to determine whether the benefits of prostate cancer screening outweigh the costs and harms caused by over-detection and over-treatment, and the different approaches may impact results. METHODS: To identify models of prostate cancer used to assess the cost-effectiveness of prostate cancer screening strategies, a systematic review of articles published since 2006 was conducted using the NHS Economic Evaluation Database, Medline, EMBASE and HTA databases...
January 18, 2018: BMC Cancer
Zhengyang Bin, Haoqing Guo, Ziyang Liu, Feng Li, Lian Duan
Precursors of reactive organic radicals have been widely used as n-dopants in electron-transporting materials to improve electron-conductivity and enhance electron-injection. However, the utilization of organic radicals in hole-counterparts has been ignored. In this work, stable organic radicals have been proved for the first time to be efficient dopants to enhance hole injection. From the absorbance spectra and the ultraviolet photoelectron spectra, we could observe an efficient electron transfer between the organic radical (4-N-carbazolyl-2,6-dichlorophenyl)bis(2,4,6-trichlorophenyl)methyl, TTM-1Cz) and the widely used hole injection material (1,4,5,8,9,11-hexaazatriphenylene hexacarbonitrile, HAT-CN)...
January 18, 2018: ACS Applied Materials & Interfaces
Herney A García-Perdomo, James A Zapata-Copete, Diego F Castillo-Cobaleda
Purpose: To determine the effectiveness and harm of cytoreductive nephrectomy versus no intervention in patients with metastatic renal carcinoma who undergo targeted therapy to improve overall survival. Materials and Methods: A search strategy was conducted in the MEDLINE, CENTRAL, Embase, HTA, DARE, NHS, and LILACS databases. Searches were also conducted for unpublished literature through references from relevant articles identified through the search, conferences, thesis databases, OpenGrey, Google Scholar, and clinicaltrials...
January 2018: Investigative and Clinical Urology
Markus M Luedi, Sanjay K Singh, Jennifer C Mosley, Islam S A Hassan, Masumeh Hatami, Joy Gumin, Lukas Andereggen, Erik P Sulman, Frederick F Lang, Frank Stueber, Gregory N Fuller, Rivka R Colen, Pascal O Zinn
OBJECTIVE Dexamethasone, a known regulator of mesenchymal programming in glioblastoma (GBM), is routinely used to manage edema in GBM patients. Dexamethasone also activates the expression of genes, such as CEBPB, in GBM stem cells (GSCs). However, the drug's impact on invasion, proliferation, and angiogenesis in GBM remains unclear. To determine whether dexamethasone induces invasion, proliferation, and angiogenesis in GBM, the authors investigated the drug's impact in vitro, in vivo, and in clinical information derived from The Cancer Genome Atlas (TCGA) cohort...
January 12, 2018: Journal of Neurosurgery
Shuai Zhang, Yanhong Huang, Jingling Zhu, Liya Shan, Jianfeng Gao, Yunhua Zhang, Na Yu, Lei Yang, Jin Huang
Neuritin plays an important role in the development and regeneration of the nervous system, and shows good prospects in the treatment and protection of the nervous system. To characterize neuritin function, we constructed a baculovirus expression system of neuritin, and identified the biological activity of the neuritin protein. The results and showed that the expression product could promote the neurite growth of dorsal root ganglion in chicken embryos. The neuritin open reading frame was amplified and cloned into the plasmid pFastBac™HTA...
January 7, 2018: Gene
Ilargi Gorostegi-Anduaga, Pablo Corres, Aitor MartinezAguirre-Betolaza, Javier Pérez-Asenjo, G Rodrigo Aispuru, Simon M Fryer, Sara Maldonado-Martín
Background Both exercise training and diet are recommended to prevent and control hypertension and overweight/obesity. Purpose The purpose of this study was to determine the effectiveness of different 16-week aerobic exercise programmes with hypocaloric diet on blood pressure, body composition, cardiorespiratory fitness and pharmacological treatment. Methods Overweight/obese, sedentary participants ( n = 175, aged 54.0 ± 8.2 years) with hypertension were randomly assigned into an attention control group (physical activity recommendations) or one of three supervised exercise groups (2 days/week: high-volume with 45 minutes of moderate-intensity continuous training (MICT), high-volume and high-intensity interval training (HIIT), alternating high and moderate intensities, and low-volume HIIT (20 minutes))...
January 1, 2018: European Journal of Preventive Cardiology
K L Cheung, S M A A Evers, H De Vries, P Levy, S Pokhrel, T Jones, M Danner, J Wentlandt, L Knufinke, S Mayer, M Hiligsmann
BACKGROUND: To enhance usage of health technology assessment (HTA) in decision-making, it is important to prioritise important barriers and facilitators to the uptake of HTA. This study aims to quantify and compare the relative importance of barriers and facilitators regarding the use of HTA in several European countries. METHODS: A survey containing two best-worst scaling (BWS) object case studies (i.e. barriers and facilitators) were conducted among 136 policy makers and HTA researchers from the Netherlands, Germany, France, and United Kingdom...
January 5, 2018: Expert Review of Pharmacoeconomics & Outcomes Research
Wenbin Liu, Lizheng Shi, Raymond W Pong, Hengjin Dong, Yiwei Mao, Meng Tang, Yingyao Chen
BACKGROUND: For health technology assessment (HTA) to be more policy relevant and for health technology-related decision-making to be truly evidence-based, promoting knowledge translation (KT) is of vital importance. Although some research has focused on KT of HTA, there is a dearth of literature on KT determinants and the situation in developing countries and transitional societies remains largely unknown. OBJECTIVE: To investigate the determinants of HTA KT from research to health policy-making from the perspective of researchers in China...
2018: PloS One
Wiebke Hoffmann-Eßer, Ulrich Siering, Edmund A M Neugebauer, Ulrike Lampert, Michaela Eikermann
OBJECTIVE: To investigate whether AGREE II users apply a cut-off based on standardized domain scores or overall guideline quality in order to distinguish between high- and low-quality guidelines, as well as to investigate which criteria they use to generate this cut-off and which type of cut-off they apply. STUDY DESIGN AND SETTING: We conducted a systematic search in MEDLINE, EMBASE, DARE, and the HTA-Database for German- and English-language studies appraising guidelines with AGREE II...
December 26, 2017: Journal of Clinical Epidemiology
Maxine F Robinson, Cathrine Mihalopoulos, Tracy Merlin, Elizabeth Roughead
OBJECTIVES: Australia relies on managed entry agreements (MEAs) for many medicines added to the national Pharmaceutical Benefits Scheme (PBS). Previous studies of Australian MEAs examined public domain documents and were not able to provide a comprehensive assessment of the types and operation of MEAs. This study used government documents approved for release to examine the implementation and administration of MEAs implemented January 2012 to May 2016. METHODS: We accessed documents for medicines with MEAs on the PBS between January 2012 and May 2016...
December 26, 2017: International Journal of Technology Assessment in Health Care
Yi Wan, Sihua Jin, Chendong Ma, Zhicheng Wang, Qi Fang, Runshen Jiang
Eggs with a much higher proportion of thick albumen are preferred in the layer industry, as they are favoured by consumers. However, the genetic factors affecting the thick egg albumen trait have not been elucidated. Using RNA sequencing, we explored the magnum transcriptome in 9 Rhode Island white layers: four layers with phenotypes of extremely high ratios of thick to thin albumen (high thick albumen, HTA) and five with extremely low ratios (low thick albumen, LTA). A total of 220 genes were differentially expressed, among which 150 genes were up-regulated and 70 were down-regulated in the HTA group compared with the LTA group...
December 22, 2017: Scientific Reports
Luyao Xia, Lixia Cui, Qin Zhang, Xiaofei Dong, Guangyuan Shi
There are still some controversies that attentional bias to negative emotions in individuals with high-trait anxiety (HTA), as compare with those with low-trait anxiety (LTA), occurs in the engagement or disengagement facet of attentional selectivity and whether this attentional bias is affected by negative emotional types. In this study, we explored the different attentional selectivity mechanisms for threatening emotions of anger and disgust between individuals with HTA and LTA using the variant attentional-probe paradigm...
December 19, 2017: Neuroreport
Katharina Hawlik, Patrick Rummel, Claudia Wild
OBJECTIVES: Strengthening efforts toward better collaboration plays a pivotal role in the assessment of medical devices to reduce overlap and save resources. This study explored the level of duplication in health technology assessments (HTA) of medical devices in Europe and their respective timing in order to identify areas for better collaboration. METHODS: An analysis of European HTA reports of medical devices regarding overlaps in topics and timing in relation to market authorization was performed...
December 20, 2017: International Journal of Technology Assessment in Health Care
Britta Olberg, Sabine Fuchs, Dimitra Panteli, Matthias Perleth, Reinhard Busse
BACKGROUND: The aim of this study was to examine the scientific evidence on clinical effectiveness and safety used in health technology assessments (HTAs) of high-risk medical devices (MDs) in Europe. METHODS: We applied a systematic approach to identify European institutions involved in HTA and to select reports assessing MDs considered high-risk according to the definition in the new German health care regulation §137h. Reports published between 2010 and 2015 were considered in our subsequent analysis...
December 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
Elizabeth A Griffiths, Richard Macaulay, Nirma K Vadlamudi, Jasim Uddin, Ebony R Samuels
BACKGROUND: Many health technology assessment (HTA) agencies express a preference for randomized controlled trial evidence when appraising health technologies; nevertheless, it is not always feasible or ethical to conduct such comparative trials. OBJECTIVES: To assess the role of noncomparative evidence in HTA decision making. METHODS: The Web sites of the National Institute for Health and Care Excellence (NICE) in the United Kingdom, the Canadian Agency for Drugs and Technologies in Health (CADTH) in Canada, and the Institute for Quality and Efficiency in Health Care (Institut für Qualität und Wirtschaftlichkeit im Gesundheitswesen [IQWiG]) in Germany were searched for single HTA reports (published between January 2010 and December 2015)...
December 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
Tara Schuller, Sophie Söderholm Werkö
This mini-theme contains six stories of health technology assessment (HTA) impact from member agencies of The International Network of Agencies for Health Technology Assessment (INAHTA), which were originally shared at the 2015 and 2016 INAHTA Congresses. The INAHTA impact story sharing is an innovative network activity where member agency representatives share experiences of HTA impact in a loosely structured story format. Through this process, members gain insights from other agencies on new ways of thinking about and approaching HTA impact assessment...
January 2017: International Journal of Technology Assessment in Health Care
Ruth Backman, Susan Bayliss, David Moore, Ian Litchfield
BACKGROUND: Integrated reminders within clinical systems have become more prevalent due to the use of electronic health records and evidence demonstrating an increase in compliance within practice. Clinical reminders are assessed for effectiveness on an individual basis, rather than in combination with existing prompts for other conditions. The growing number of prompts may be counter-productive as healthcare professionals are increasingly suffering from "reminder fatigue" meaning many reminders are ignored...
December 13, 2017: Systematic Reviews
Frances Bunn, Claire Goodman, Peter Reece Jones, Bridget Russell, Daksha Trivedi, Alan Sinclair, Antony Bayer, Greta Rait, Jo Rycroft-Malone, Chris Burton
BACKGROUND: Dementia and diabetes mellitus are common long-term conditions that coexist in a large number of older people. People living with dementia and diabetes may be at increased risk of complications such as hypoglycaemic episodes because they are less able to manage their diabetes. OBJECTIVES: To identify the key features or mechanisms of programmes that aim to improve the management of diabetes in people with dementia and to identify areas needing further research...
December 2017: Health Technology Assessment: HTA
Olga Löblová
Health technology assessment (HTA) has over the past three decades become a well-established part of decisions about allocation of resources in many countries. Despite this, little is known about HTA's impact on health systems. Few studies have evaluated the benefits of HTA for health outcomes, for access to care or for public budgets. In contrast, HTA has relatively clear upfront costs, which could potentially discourage policy-makers from establishing HTA agencies, especially in low income countries with restricted resources...
January 1, 2017: Journal of Health Services Research & Policy
Meysam Eyvazlou, Ali Dadashpour Ahangar, Azin Rahimi, Mohammad Reza Davarpanah, Seyed Soheil Sayyahi, Mehdi Mohebali
INTRODUCTION: Reducing human error is an important factor for enhancing safety protocols in various industries. Hence, the analysis of the likelihood of human error in nuclear industries such as radiopharmaceutical production facilities has become more essential. METHODS: This cross-sectional descriptive study was conducted to quantify the probability of human errors in a 99Mo/99mTc generator production facility in Iran. First, through expert interviews, the production process of 99Mo/99mTc generator was analyzed using hierarchical task analysis (HTA) method...
December 11, 2017: International Journal of Occupational Safety and Ergonomics: JOSE
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