keyword
MENU ▼
Read by QxMD icon Read
search

Congenital toxoplasmosis

keyword
https://www.readbyqxmd.com/read/29769499/toxoplasma-gondii-seropositivity-and-its-possible-associated-risk-factors-among-pregnant-women-attending-antenatal-clinic-in-a-tertiary-care-hospital-of-dhaka-bangladesh
#1
C R Naheen, S Tarafder, S Khan
Toxoplasmosis is a well-documented cause of bad obstetric history (BOH) and a major reason of congenitally acquired infection. This observational study was conducted to detect the rate of seropositivity of toxoplasmosis in pregnant women and observe their risk factors associated with disease transmission attending the antenatal clinic of the Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh from July 2015 to August 2016. The study subjects included 150 pregnant women of different gestational ages...
April 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29749872/secondary-prophylaxis-of-toxoplasmosis-in-pregnancy-in-an-hiv-positive-woman
#2
Subathira Dakshina, Robert F Miller, Cheuk Yw Tong, Liat Sarner
A 39-year-old HIV-positive black African woman with previously treated cerebral toxoplasmosis experienced a foetal intra-uterine death due to congenital toxoplasmosis. This case demonstrates the complexities of screening for maternal toxoplasmosis in the context of pregnancy and HIV infection-related cell-mediated immunosuppression. Additionally, the case highlights the challenges in providing effective preventative and therapeutic drug options for congenital toxoplasmosis.
January 1, 2018: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/29675078/novel-rab3gap1-mutations-causing-warburg-micro-syndrome-in-two-italian-sisters
#3
Pasquale Loiudice, Debora Napoli, Maria Cristina Ragone, Marco Nardi, Giamberto Casini
This report details two novel RAB3GAP1 mutations causing Warburg Micro syndrome, a rare autosomal recessive disorder characterized by multiple organ abnormalities involving the ocular, nervous, and endocrine systems. Two Italian sisters were referred to our department for the assessment of congenital bilateral cataracts. They also presented with microphthalmia, postnatal microcephaly, severe developmental delay, and hypotony. Perinatal investigations were negative for any toxins or infectious diseases during pregnancy, including toxoplasmosis, rubella, cytomegalovirus, and herpes virus...
October 2017: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/29673005/seroepidemiological-map-of-toxoplasma-gondii-infection-and-associated-risk-factors-in-preconception-period-in-china-a-nationwide-cross-sectional-study
#4
Qiongjie Zhou, Qiaomei Wang, Haiping Shen, Yiping Zhang, Shikun Zhang, Xiaotian Li, Ganesh Acharya
AIM: The aims of this study were to investigate the regional differences in seroepidemiology of toxoplasmosis in preconception period among Chinese women of reproductive age and to evaluate associated risk factors. METHODS: This national, population-based, cross-sectional serosurvey covered all 31 provinces and province-level municipalities in Mainland China. Married women intending to get pregnant within 6 months between 2010 and 2012 were recruited. Information on demographic characteristics (age, place of residence, occupation, dietary habits and exposure to cat) was obtained using interviews, and venous blood samples were collected to screen for Toxoplasma gondii infection...
April 19, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29669003/live-attenuated-pru-%C3%AE-cdpk2-strain-of-toxoplasma-gondii-protects-against-acute-chronic-and-congenital-toxoplasmosis
#5
Jin-Lei Wang, Ting-Ting Li, Hany M Elsheikha, Kai Chen, Wei Cong, Wen-Bin Yang, Meng-Jie Bai, Si-Yang Huang, Xing-Quan Zhu
Background: The threat of Toxoplasma gondii infection in immunocompromised individuals and pregnant women necessitates the development of a safe and effective vaccine. Here, we examined the immune protection conferred by live-attenuated strain of T. gondii. Methods: We tested the efficacy of intraperitoneal vaccination using 500 Ca2+-dependent protein kinase 2 (cdpk2)-deficient tachyzoites of T. gondii Pru strain against acute, chronic and congenital toxoplasmosis in mice...
April 13, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29668747/prevalence-of-toxoplasmosis-and-genetic-characterization-of-toxoplasma-gondii-strains-isolated-in-wild-birds-of-prey-and-their-relation-with-previously-isolated-strains-from-turkey
#6
Muhammet Karakavuk, Duygu Aldemir, Aurélien Mercier, Esra Atalay Şahar, Hüseyin Can, Jean-Benjamin Murat, Ömer Döndüren, Şengül Can, Hüseyin Gökhan Özdemir, Aysu Değirmenci Döşkaya, Bayram Pektaş, Marie-Laure Dardé, Adnan Yüksel Gürüz, Mert Döşkaya
Toxoplasma gondii is a protozoon parasite that causes congenital toxoplasmosis, as well as other serious clinical presentations, in immune compromised humans. Analyses of the prevalence and genotyping of strains from the definitive host and intermediate hosts will help to understanding the circulation of the different strains and elucidating the role of the genotype(s) in human toxoplasmosis. Turkey has a specific geographic location bridging Africa, Europe, and Asia. We hypothesized that T. gondii strains may have been transferred to Turkey from these continents via migratory birds or vice versa...
2018: PloS One
https://www.readbyqxmd.com/read/29663900/congenital-toxoplasmosis-in-tunisia-prenatal-and-neonatal-diagnosis-and-postnatal-follow-up-of-35-cases
#7
Boudaouara Yosr, Aoun Karim, Maatoug Rania, Souissi Olfa, Bouratbine Aïda, Ben Abdallah Rym
Congenital toxoplasmosis (CT) results from transplacental passage of Toxoplasma gondii to the fetus during acute maternal infection. Our study aims to report clinical and biological patterns of 35 cases of CT diagnosed at the department of the Parasitology of the Pasteur Institute of Tunis and to access the performance of prenatal and early postnatal diagnosis techniques. Serological screening of maternal infection was performed by Immunoglobulin (Ig) M and IgG detection and IgG avidity determination. Prenatal diagnosis was based on both Toxoplasma DNA detection in the amniotic fluid and monthly ultrasound examinations...
April 16, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29652970/-congenital-toxoplasmosis-serology-pcr-parasite-isolation-and-molecular-characterization-of-toxoplasma-gondii
#8
Liliana Carral, Federico Kaufer, Lais Pardini, Ricardo Durlach, Gastón Moré, María C Venturini, Cristina Freuler
Congenital toxoplasmosis diagnosis in the newborn is a very important issue due to the need for early treatment to prevent future sequels. Aim To compare available methods at the institution for the diagnosis of congenital toxoplasmosis. Material and Methods In this study we have evaluated the different diagnostic tests used in 67 congenital exposed newborns, including serological tests, PCR, parasite isolation and molecular characterization. Results The ISAGA IgM and IgA tests showed sensitivity (Se) of 87 and 91%, respectively, and specificity (Sp) of 100%...
2018: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/29619433/increased-apoptosis-skull-of-pups-born-to-toxoplasma-gondii-infected-mice-associated-with-increased-expression-of-interferon-gamma-but-not-tumor-necrosis-factor-alfa
#9
Lucia Tri Suwanti, Mufasirin
Bacground: Toxoplasma gondii is an intracellular obligate protozoan parasite that infects most warm-blooded animals including humans. It can cause congenital infection with clinical symptoms ranging from mild to severe including microcephaly. At the cellular level, infection T. gondii causes apoptosis in some tissues and it is induced by proinflammatory cytokines, such as IFN-γ and TNF-α. The purpose of this study is to determine the role of proinflammatory cytokines (TNF-α and IFN-γ) to apoptosis skull of newborn from T...
2018: African Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29604343/use-of-polymerase-chain-reaction-pcr-in-the-diagnosis-of-congenital-toxoplasmosis
#10
C Loveridge-Easther, Anne-Marie Yardley, Brenda Breidenstein
No abstract text is available yet for this article.
March 28, 2018: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/29573417/what-do-anti-toxoplasma-gondii-iga-and-igg-subclasses-in-human-saliva-indicate
#11
I Cañedo-Solares, F Gómez-Chávez, H Luna-Pastén, L B Ortiz-Alegría, Y Flores-García, R Figueroa-Damián, C A Macedo-Romero, D Correa
Diagnostic tests for toxoplasmosis are based on serological techniques due to their high sensitivity. Some IgG subclasses are related to clinical outcome in the congenital form. In this work, we determined the levels of IgG, IgA, IgG1, IgG2, IgG3 and IgG4 anti-Toxoplasma gondii antibodies in paired saliva and serum samples from 91 women by indirect ELISA using a crude extract of the RH strain. The levels of IgA, IgG2, IgG3 and IgG4 antibodies and, to a lesser extent, IgG1 did not correlate between saliva and serum, that is, most cases that were positive for one Ig class in a sample were negative or very low in the other, and vice versa...
May 2018: Parasite Immunology
https://www.readbyqxmd.com/read/29562870/sleep-eeg-of-microcephaly-in-zika-outbreak
#12
Paulo Afonso Medeiros Kanda, Aline de Almeida Xavier Aguiar, Jose Lucivan Miranda, Alexandre Loverde Falcao, Claudia Suenia Andrade, Luigi Neves Dos Santos Reis, Ellen White R Bacelar Almeida, Yanes Brum Bello, Arthur Monfredinho, Rafael Guimaraes Kanda
Microcephaly (MC), previously considered rare, is now a health emergency of international concern because of the devastating Zika virus pandemic outbreak of 2015. The authors describe the electroencephalogram (EEG) findings in sleep EEG of epileptic children who were born with microcephaly in areas of Brazil with active Zika virus transmission between 2014 and 2017. The authors reviewed EEGs from 23 children. Nine were females (39.2%), and the age distribution varied from 4 to 48 months. MC was associated with mother positive serology to toxoplasmosis (toxo), rubella (rub), herpes, and dengue (1 case); toxo (1 case); chikungunya virus (CHIKV) (1 case); syphilis (1 case); and Zika virus (ZIKV) (10 cases)...
2018: Neurodiagnostic Journal
https://www.readbyqxmd.com/read/29561516/decline-of-seroprevalence-and-incidence-of-congenital-toxoplasmosis-despite-changing-prevention-policy-three-decades-of-cord-blood-screening-in-north-western-switzerland
#13
Christoph Rudin, Hans H Hirsch, Rahel Spaelti, Sabine Schaedelin, Thomas Klimkait
BACKGROUND: Due to the lack of prospective data there is an ongoing debate about the need for screening and prevention programs for congenital toxoplasmosis in Europe. Accordingly, individual countries have chosen different public health strategies. METHODS: A cord-blood screening program for congenital toxoplasmosis was established in 1982 in obstetric units of hospitals in North-Western Switzerland. Samples were tested for specific IgG and IgM, and after 1992 also for IgA antibodies...
March 14, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29524527/imidazo-1-2-b-pyridazines-targeting-toxoplasma-gondii-calcium-dependent-protein-kinase-1-decrease-the-parasite-burden-in-mice-with-acute-toxoplasmosis
#14
Espérance Moine, Nathalie Moiré, Isabelle Dimier-Poisson, Kévin Brunet, William Couet, Cyril Colas, Nathalie Van Langendonck, Cécile Enguehard-Gueiffier, Alain Gueiffier, Bruno Héraut, Caroline Denevault-Sabourin, Françoise Debierre-Grockiego
The current therapeutic arsenal for toxoplasmosis is restricted to drugs non-specific to the parasite which cause important side effects. Development of more efficient and specific anti-Toxoplasma compounds is urgently needed. Imidazo[1,2-b]pyridazines designed to inhibit the calcium-dependent protein kinase 1 of Toxoplasma gondii (TgCDPK1) and effective against tachyzoite growth in vitro at submicromolar ranges were modified into hydrochloride salts to be administered in vivo in a mouse model of acute toxoplasmosis...
March 7, 2018: International Journal for Parasitology
https://www.readbyqxmd.com/read/29476868/a-new-lamp-based-assay-for-the-molecular-diagnosis-of-toxoplasmosis-comparison-with-a-proficient-pcr-assay
#15
Emmanuelle Varlet-Marie, Yvon Sterkers, Marina Perrotte, Patrick Bastien
Toxoplasmosis is generally a benign infection caused by the protozoan parasite Toxoplasma gondii but can have severe consequences in fetuses of mothers infected during pregnancy (congenital toxoplasmosis) and immunocompromised individuals. PCR-based diagnostic tests have become crucial for its diagnosis. However, this molecular diagnosis essentially relies upon laboratory-developed methods and suffers from a lack of standardization, leading to great variation in methods and performance among laboratories. With the need for accreditation of clinical microbiological laboratories, the use of commercial PCR kits has become an attractive alternative; but thorough evaluation of newly commercialized kits by proficient groups is necessary before any recommendation can be made to parasitology laboratories by health authorities or learned societies...
May 2018: International Journal for Parasitology
https://www.readbyqxmd.com/read/29473896/congenital-toxoplasmosis-a-plea-for-a-neglected-disease
#16
Martine Wallon, François Peyron
Maternal infection by Toxoplasma gondii during pregnancy may have serious consequences for the fetus, ranging from miscarriage, central nervous system involvement, retinochoroiditis, or subclinical infection at birth with a risk of late onset of ocular diseases. As infection in pregnant women is usually symptomless, the diagnosis relies only on serological tests. Some countries like France and Austria have organized a regular serological testing of pregnant women, some others have no prenatal program of surveillance...
February 23, 2018: Pathogens
https://www.readbyqxmd.com/read/29452213/nanoemulsion-of-atovaquone-as-a-promising-approach-for-treatment-of-acute-and-chronic-toxoplasmosis
#17
Sanaz Jafarpour Azami, Amir Amani, Hossein Keshavarz, Roqya Najafi-Taher, Mehdi Mohebali, Mohammad Ali Faramarzi, Mahmood Mahmoudi, Saeedeh Shojaee
Treatment of toxoplasmosis is necessary in congenital form and immunocompromised patients. Atovaquone is a powerful suppressor of protozoan parasites with a broad-spectrum activity, but an extremely low water solubility and bioavailability. In this study, nanoemulsion of this drug was prepared with grape seed oil using spontaneous emulsification method to increase bioavailability and efficacy of atovaquone for treatment of toxoplasmosis. In vitro activity of atovaquone nanoemulsion against T. gondii, RH and Tehran strains, was assessed in HeLa cell culture...
May 30, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29412347/microcephaly-in-piau%C3%A3-brazil-descriptive-study-during-the-zika-virus-epidemic-2015-2016
#18
Igor Gonçalves Ribeiro, Marcia Regina de Andrade, Janaína de Moraes Silva, Zenira Martins Silva, Maria Amélia de Oliveira Costa, Marcelo Adriano da Cunha E Silva Vieira, Francisca Miriane de Araújo Batista, Herlon Guimarães, Marcelo Yoshito Wada, Eduardo Saad
OBJECTIVE: to describe the occurrence and characteristics of microcephaly cases in Piauí, Brazil, during an epidemic of Zika virus infection in 2015-2016. METHODS: descriptive study using data of live births from January/2015 to January/2016, obtained from the Information System on Live Births (Sinasc), the Public Health Events Registry (RESP) and the active search for medical records; mothers and live births were tested for dengue, chikungunya, and Zika, besides syphilis, toxoplasmosis, rubella, cytomegalovirus, and herpes (STORCH)...
February 1, 2018: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
https://www.readbyqxmd.com/read/29373837/evaluation-of-five-automated-and-one-manual-method-for-toxoplasma-and-human-dna-extraction-from-artificially-spiked-amniotic-fluid
#19
H Yera, L Ménégaut, M-P Brenier-Pinchart, F Touafek, P Bastien, F Dalle
OBJECTIVES: Molecular detection of Toxoplasma gondii plays a crucial role in the prenatal and neonatal diagnosis of congenital toxoplasmosis (CT). Sensitivity of this diagnosis is partly related to the efficiency of parasite DNA extraction and amplification. DNA extraction methods with automated platforms have been developed. Therefore, it is essential to evaluate them in combination with adequate PCR amplification assays. METHODS: In this multisite study, we investigated the suitability of two recent automated procedures for the isolation of Toxoplasma DNA from amniotic fluid (AF) (Magtration system 12GC, PSS and Freedom EVO VacS, Tecan), compared with three other automated procedures (MagNAPure Compact, Roche, BioRobot EZ1, Qiagen and modified NucliSens easyMAG, bioMérieux) and with the manual DNA extraction QIAamp DNA Mini kit (Qiagen)...
January 31, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29330674/advances-in-serological-imaging-techniques-and-molecular-diagnosis-of-toxoplasma-gondii-infection
#20
REVIEW
Ali Rostami, Panagiotis Karanis, Shirzad Fallahi
BACKGROUND: Toxoplasmosis is worldwide distributed zoonotic infection disease with medical importance in immunocompromised patients, pregnant women and congenitally infected newborns. Having basic information on the traditional and new developed methods is essential for general physicians and infectious disease specialists for choosing a suitable diagnostic approach for rapid and accurate diagnosis of the disease and, consequently, timely and effective treatment. METHODS: We conducted English literature searches in PubMed from 1989 to 2016 using relevant keywords and summarized the recent advances in diagnosis of toxoplasmosis...
January 12, 2018: Infection
keyword
keyword
53951
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"