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Congenital toxoplasmosis

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https://www.readbyqxmd.com/read/28207736/congenital-toxoplasmosis-in-france-and-the-united-states-one-parasite-two-diverging-approaches
#1
Francois Peyron, Rima Mc Leod, Daniel Ajzenberg, Despina Contopoulos-Ioannidis, François Kieffer, Laurent Mandelbrot, L David Sibley, Hervé Pelloux, Isabelle Villena, Martine Wallon, Jose G Montoya
No abstract text is available yet for this article.
February 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28202794/evaluation-of-the-toxoplasma-elite-mgb%C3%A2-real-time-pcr-assay-for-the-diagnosis-of-toxoplasmosis
#2
Florence Robert-Gangneux, Marie-Pierre Brenier-Pinchart, Hélène Yera, Sorya Belaz, Emmanuelle Varlet-Marie, Patrick Bastien
Molecular diagnosis of congenital toxoplasmosis or disseminated toxoplasmosis is mainly based on PCR. The repeated DNA element rep529 has become the main DNA target used in most, whether laboratory-developed or commercial, PCR methods. In this multicenter study, we evaluated the Toxoplasma ELITe MGB® (Elitech®) commercial kit, by comparison with three reference quantitative PCR assays (RA) used in routine in three proficient laboratories of the French National Reference Center for Toxoplasmosis network, using Toxoplasma calibrated suspensions diluted to obtain a range of concentrations from 0...
February 15, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28187119/in-reply-sulfadoxine-pyrimethamine-combination-in-congenital-toxoplasmosis
#3
Damien Dupont, François Peyron
No abstract text is available yet for this article.
March 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28187118/sulfadoxine-pyrimethamine-combination-in-congenital-toxoplasmosis
#4
Cathy Chemla, Isabelle Villena
No abstract text is available yet for this article.
March 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28163699/a-systematic-review-of-in-vitro-and-in-vivo-activities-of-anti-toxoplasma-drugs-and-compounds-2006-2016
#5
REVIEW
Mahbobeh Montazeri, Mehdi Sharif, Shahabeddin Sarvi, Saeed Mehrzadi, Ehsan Ahmadpour, Ahmad Daryani
The currently available anti-Toxoplasma agents have serious limitations. This systematic review was performed to evaluate drugs and new compounds used for the treatment of toxoplasmosis. Data was systematically collected from published papers on the efficacy of drugs/compounds used against Toxoplasma gondii (T. gondii) globally during 2006-2016. The searched databases were PubMed, Google Scholar, Science Direct, ISI Web of Science, EBSCO, and Scopus. One hundred and eighteen papers were eligible for inclusion in this systematic review, which were both in vitro and in vivo studies...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28151845/high-frequency-of-bone-marrow-depression-during-congenital-toxoplasmosis-therapy-in-a-cohort-of-children-identified-by-neonatal-screening-in-minas-gerais-brazil
#6
Ericka Viana Machado Carellos, Juliana Queiroz de Andrade, Roberta Maia Castro Romanelli, Jacqueline Domingos Tibúrcio, José Nélio Januário, Daniel Vítor Vasconcelos-Santos, Rosângela Maria Figueiredo, Gláucia Manzan Queiroz de Andrade
BACKGROUND: There are few studies reporting frequency and control of adverse events associated with congenital toxoplasmosis treatment. The objective of this study is to describe treatment adherence and adverse hematologic events in a cohort of children identified with congenital toxoplasmosis in Minas Gerais, Brazil. METHODS: Children were treated with sulfadiazine, pyrimethamine and folinic acid and were evaluated clinically and by laboratory tests at regular intervals...
January 31, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28148555/targeting-toxoplasma-gondii-cpsf3-as-a-new-approach-to-control-toxoplasmosis
#7
Andrés Palencia, Alexandre Bougdour, Marie-Pierre Brenier-Pinchart, Bastien Touquet, Rose-Laurence Bertini, Cristina Sensi, Gabrielle Gay, Julien Vollaire, Véronique Josserand, Eric Easom, Yvonne R Freund, Hervé Pelloux, Philip J Rosenthal, Stephen Cusack, Mohamed-Ali Hakimi
Toxoplasma gondii is an important food and waterborne pathogen causing toxoplasmosis, a potentially severe disease in immunocompromised or congenitally infected humans. Available therapeutic agents are limited by suboptimal efficacy and frequent side effects that can lead to treatment discontinuation. Here we report that the benzoxaborole AN3661 had potent in vitro activity against T. gondii Parasites selected to be resistant to AN3661 had mutations in TgCPSF3, which encodes a homologue of cleavage and polyadenylation specificity factor subunit 3 (CPSF-73 or CPSF3), an endonuclease involved in mRNA processing in eukaryotes...
February 1, 2017: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/28138769/molecular-and-virulence-characterization-of-toxoplasma-gondii-strains-isolated-from-humans-in-portugal
#8
Anabela Vilares, Maria João Gargaté, Idalina Ferreira, Susana Martins, João Paulo Gomes
Toxoplasma gondii is an apicomplexan parasite responsible for toxoplasmosis which infects all warm-blooded vertebrates, including mammals and birds. The majority of studies conducted in Europe have revealed that more than 80 % of strains isolated from human infections belong to genotype II, whereas genotypes I and III are responsible for a small number of cases. Atypical and recombinant strains are generally associated with more severe infections. In Portugal, there is a lack of data concerning genetic diversity as the classical typing studies in humans have never been performed...
March 2017: Parasitology Research
https://www.readbyqxmd.com/read/28138010/diagnosis-treatment-and-prevention-of-congenital-toxoplasmosis-in-the-united-states
#9
Yvonne A Maldonado, Jennifer S Read
No abstract text is available yet for this article.
30, 2017: Pediatrics
https://www.readbyqxmd.com/read/28127354/dna-amplification-techniques-for-the-detection-of-toxoplasma-gondii-tissue-cysts-in-meat-producing-animals-a-narrative-review-article
#10
REVIEW
Farooq Riaz, Imran Rashid, Haroon Akbar, Wasim Shehzad, Saher Islam, Amna Arshad Bajwa, Khalid Saeed, Kamran Ashraf
BACKGROUND: Toxoplasma gondii is an intracellular parasite, which infects one-third population of world. Humans and animals acquire infection by ingesting oocytes from feces of cats or by meat of other animals having cysts that may lead to congenital, ocular or cephalic toxoplasmosis. Either it is important to detect T. gondii from meat of food animals from retail shops or directly at slaughterhouses, which is meant for export. METHODS: The current research was done without time limitation using such terms as follows: "Toxoplasma gondii", "Meat", "Tissue cyst", "PCR", "LAMP", "Screening" and "Immunological assay" alone or in combination, in English language...
October 2016: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/28126016/seroprevalence-of-toxoplasma-gondii-and-associated-risk-factors-among-hiv-infected-women-within-reproductive-age-group-at-mizan-aman-general-hospital-southwest-ethiopia-a-cross-sectional-study
#11
Ayalew Jejaw Zeleke, Yayehirad Alemu Melsew
BACKGROUND: Toxoplasmosis is serious in the case of immune suppression and prenatal transmission. In immunocompromised hosts, it is manifested primarily as a life-threatening condition, toxoplasmic encephalitis. Congenital toxoplasmosis results in abortion or congenitally acquired disorders which primarily affect the central nervous system. This study assessed seroprevalence of Toxoplasma gondii (T. gondii) infection and associated factors among HIV-infected women within the reproductive age group (18-49 years) at Mizan Aman General Hospital, Southwest Ethiopia...
January 26, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28118394/genetic-polymorphisms-and-phenotypic-profiles-of-sulfadiazine-resistant-and-sensitive-toxoplasma-gondii-isolates-obtained-from-newborns-with-congenital-toxoplasmosis-in-minas-gerais-brazil
#12
Letícia Azevedo Silva, João Luís Reis-Cunha, Daniella Castanheira Bartholomeu, Ricardo Wagner Almeida Vítor
BACKGROUND: Previous Toxoplasma gondii studies revealed that mutations in the dhps (dihydropteroate synthase) gene are associated with resistance to sulfonamides. Although Brazilian strains are genotypically different, very limited data are available regarding the susceptibility of strains obtained from human to sulfonamides. The aim of this study was to evaluate the efficacy of sulfadiazine (SDZ) against Brazilian isolates of T. gondii and verify whether isolates present polymorphisms in the dhps gene...
2017: PloS One
https://www.readbyqxmd.com/read/28042412/molecular-detection-and-genotypic-characterization-of-toxoplasma-gondii-in-paraffin-embedded-fetoplacental-tissues-of-women-with-recurrent-spontaneous-abortion
#13
Amir Abdoli, Abdolhossein Dalimi, Haleh Soltanghoraee, Fatemeh Ghaffarifar
BACKGROUND: Congenital toxoplasmosis is an important cause of spontaneous abortion worldwide. However, there is limited information on detection and genotypic characterization of Toxoplasma gondii (T. gondii) in women with recurrent spontaneous abortion (RSA). The aim of this study is the molecular detection and genotypic characterization of T. gondii in formalin-fixed, paraffin-embedded fetoplacental tissues (FFPTs) of women with RSA that have referred to the Avicenna Research Institute in Tehran, Iran...
January 2017: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/28030925/comparison-of-the-efficiency-of-two-commercial-kits-elfa-and-western-blot-in-estimating-the-phase-of-toxoplasma-gondii-infection-in-pregnant-women
#14
COMPARATIVE STUDY
Jacek Sroka, Angelina Wójcik-Fatla, Violetta Zając, Anna Sawczyn, Ewa Cisak, Jacek Karamon, Jacek Dutkiewicz, Iwona Bojar
Sera of 89 pregnant women were selected according to the results of ELFA IgM, IgG and avidity IgG, and tested with commercial tests IgM, IgG and avidity IgG Western Blot (WB) to compare the efficacy of both techniques in determining the phase of T. gondii infection. In total, 81 of 89 tested sera (91.0%) were classified as positive, both in the ELFA and WB tests for the presence of anti-Toxoplasma antibodies of class IgG, indicating a past infection, while the prevalence of anti-Toxoplasma positive reactions associated with the antibodies of class IgM indicating a recent infection was much lower - 31...
23, 2016: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/28028000/phylogeography-of-toxoplasma-gondii-points-to-a-south-american-origin
#15
Emilie Bertranpetit, Thibaut Jombart, Emmanuel Paradis, Hilda Pena, Jitender Dubey, Chunlei Su, Aurélien Mercier, Sébastien Devillard, Daniel Ajzenberg
Toxoplasma gondii, a protozoan found ubiquitously in mammals and birds, is the etiologic agent of toxoplasmosis, a disease causing substantial public health burden worldwide, including about 200,000 new cases of congenital toxoplasmosis each year. Clinical severity has been shown to vary across geographical regions, with South America exhibiting the highest burden. Unfortunately, the drivers of these heterogeneities are still poorly understood, and the geographical origin and historical spread of the pathogen worldwide are currently uncertain...
December 24, 2016: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/27988201/early-detection-of-toxoplasma-gondii-infection-by-using-a-interferon-gamma-release-assay-a-review
#16
REVIEW
Shima Mahmoudi, Setareh Mamishi, Xun Suo, Hossein Keshavarz
Antibody-based serological tests are currently the most common diagnostic methods for detection of Toxoplasma gondii; however, these tests bear several limitations. Recently, Interferon-gamma release assay (IGRA), a T-cell-based test, was introduced as an in vitro test for detection of T. gondii infection. Few studies have investigated the potential role of cell immunity in diagnosis of toxoplasmosis. IGRA accurately distinguished infected from uninfected individuals, showing strong lymphocyte activation after in vitro stimulation with T...
January 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/27956093/late-diagnosis-of-congenital-toxoplasmosis-based-on-serological-follow-up-a-case-report
#17
Céline Dard, Cathy Chemla, Hélène Fricker-Hidalgo, Marie-Pierre Brenier-Pinchart, Marie Baret, Alexandre Mzabi, Isabelle Villena, Hervé Pelloux
Toxoplasma gondii is a protozoan parasite infecting up to one third of the world's population. T. gondii infection is usually benign in immunocompetent patients but can be life-threatening when congenitally transmitted. Congenital toxoplasmosis presentation ranges from severe central nervous system and ocular features, to a well appearing newborn with onset of complications late in childhood. The diagnosis of subclinical form remains important since early treatment reduces later complications such as chorioretinitis...
April 2017: Parasitology International
https://www.readbyqxmd.com/read/27907933/evaluation-of-pregnant-and-postpartum-women-s-knowledge-about-toxoplasmosis-in-rio-grande-rs-brazil
#18
Lis Maurente Lehmann, Paula Costa Santos, Carlos James Scaini
Introduction Toxoplasmosis a parasitic zoonosis of global distribution, responsible for disorders during gestation can cause fetal death or congenital anomalies. Objective To evaluate the knowledge of toxoplasmosis among pregnant and postpartum women treated at the University Hospital of the city of Rio Grande, Rio Grande do Sul, Brazil. Methods This was a cross-sectional study of 100 pregnant and postpartum women at the University Hospital. Participants answered a self-administered questionnaire and gave consent for data relating to serological examinations to be abstracted from their medical records...
November 2016: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/27876900/the-common-zoonotic-protozoal-diseases-causing-abortion
#19
REVIEW
Raafat Mohamed Shaapan
Toxoplasmosis, neosporosis, sarcosporidiosis (sarcocystosis) and trypanosomiasis are the common zoonotic protozoal diseases causing abortion which caused by single-celled protozoan parasites; Toxoplasma gondii, Neospora caninum, Sarcocystis spp and Trypanosoma evansi, respectively. Toxoplasmosis is generally considered the most important disease that causing abortion of both pregnant women and different female animals throughout the world, about third of human being population had antibodies against T. gondii...
December 2016: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/27861692/-gestational-and-congenital-toxoplasmosis-a-practical-approach-to-disease-notification
#20
Jaqueline Dario Capobiango, Regina Mitsuka Breganó, Fabiana Maria Ruiz Lopes Mori, Italmar Teodorico Navarro, Josemari Sawczuk de Arruda Campos, Linda Tsuiko Tatakihara, Thalita Bento Talizin, Monica Dos Santos, Tayná Rolim Galvão Pereira, Simone Garani Narciso, Edna Maria Vissoci Reiche
OBJECTIVE: to demonstrate the experience of implanting toxoplasmosis notification during pregnancy and congenital toxoplasmosis in a Sentinel Unit (SU) and describe reported cases. METHODS: this was a descriptive study of the implantation of a notification protocol using a specific notification form for suspected cases of toxoplasmosis in pregnant women and congenital toxoplasmosis in a reference center in Paraná State, Brazil, from August 2013 to August 2014. RESULTS: all 64 suspected cases were notified and case investigation was completed by the SU Epidemiology Sector; 63 received prenatal care and 51 received treatment during pregnancy; 7 of the children being clinically monitored had confirmed diagnosis of congenital toxoplasmosis...
January 2016: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
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