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Manasi Hulyalkar, Stephen J Gleich, Rahul Kashyap, Amelia Barwise, Harsheen Kaur, Yue Dong, Lei Fan, Srinivas Murthy, Grace M Arteaga, Sandeep Tripathi
Increasing process complexity in the pediatric intensive care unit (PICU) can lead to information overload resulting in missing pertinent information and potential errors during morning rounds. An efficient model using a novel electronic rounding tool was designed as part of a broader critical care decision support system-checklist for early recognition and treatment of acute illness and injury in pediatrics (CERTAINp). We aimed to evaluate its impact on improving the process of care during rounding. Prospective pre- and post-interventional data included: team performance baseline assessment, patient safety discussion, guideline adherence, rounding time, and a survey of Residents' and Nurses' perception using a Likert scale...
October 18, 2016: Journal of Clinical Monitoring and Computing
Lydia Romund, Sabrina Golde, Robert C Lorenz, Diana Raufelder, Patricia Pelz, Tobias Gleich, Andreas Heinz, Anne Beck
The formation of a coherent and unified self-concept represents a key developmental stage during adolescence. Imaging studies on self-referential processing in adolescents are rare, and it is not clear whether neural structures involved in self-reflection are also involved in reflections of familiar others. In the current study, 41 adolescents were asked to make judgments about trait adjectives during functional magnetic resonance imaging (fMRI): they had to indicate whether the word describes themselves, their friends, their teachers or politicians...
October 11, 2016: Human Brain Mapping
Sarah Vosen, Sarah Rieck, Alexandra Heidsieck, Olga Mykhaylyk, Katrin Zimmermann, Christian Plank, Bernhard Gleich, Alexander Pfeifer, Bernd K Fleischmann, Daniela Wenzel
Gene therapy is a promising approach for chronic disorders that require continuous treatment such as cardiovascular disease. Overexpression of vasoprotective genes has generated encouraging results in animal models, but not in clinical trials. One major problem in humans is the delivery of sufficient amounts of genetic vectors to the endothelium which is impeded by blood flow, whereas prolonged stop-flow conditions impose the risk of ischemia. In the current study we have therefore developed a strategy for the efficient circumferential lentiviral gene transfer in the native endothelium under constant flow conditions...
November 10, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
Lydia Romund, Diana Raufelder, Eva Flemming, Robert C Lorenz, Patricia Pelz, Tobias Gleich, Andreas Heinz, Anne Beck
Parenting is an essential factor within a child's development, yet the impact of normative variations of parenting on neural emotion processing has not been studied to date. The present study investigated 83 healthy adolescents using functional magnetic resonance imaging and an emotional face-matching paradigm. The faces paradigm elicited an increased amygdala response towards negative facial expressions (fearful and angry each compared to neutral faces) and a significant activation of fusiform gyrus to all emotions separately (fearful, happy, angry faces) compared to neutral faces...
October 2016: Biological Psychology
Rebecca Boehme, Robert C Lorenz, Tobias Gleich, Lydia Romund, Patricia Pelz, Sabrina Golde, Eva Flemming, Andrew Wold, Lorenz Deserno, Joachim Behr, Diana Raufelder, Andreas Heinz, Anne Beck
Adolescence is a critical maturation period for human cognitive control and executive function. In this study, a large sample of adolescents (n = 85) performed a reversal learning task during functional magnetic resonance imaging. We analyzed behavioral data using a reinforcement learning model to provide individually fitted parameters and imaging data with regard to reward prediction errors (PE). Following a model-based approach, we formed two groups depending on whether individuals tended to update expectations predominantly for the chosen stimulus or also for the unchosen one...
September 15, 2016: European Journal of Neuroscience
Elena Eggl, Martin Dierolf, Klaus Achterhold, Christoph Jud, Benedikt Günther, Eva Braig, Bernhard Gleich, Franz Pfeiffer
While large-scale synchrotron sources provide a highly brilliant monochromatic X-ray beam, these X-ray sources are expensive in terms of installation and maintenance, and require large amounts of space due to the size of storage rings for GeV electrons. On the other hand, laboratory X-ray tube sources can easily be implemented in laboratories or hospitals with comparatively little cost, but their performance features a lower brilliance and a polychromatic spectrum creates problems with beam hardening artifacts for imaging experiments...
September 1, 2016: Journal of Synchrotron Radiation
Otto Gleich, Philipp Semmler, Jürgen Strutz
The potential contribution of auditory synaptopathy to age dependent hearing loss was studied in groups of young and old gerbils. The analysis of the number of inner hair cell ribbon synapses in aged gerbils (37.9±3.3months of age) revealed only a relatively small (11-17%) loss in the basal two thirds of the cochlea, while a more pronounced reduction was identified towards the apex (almost 40%) when compared to a group of young gerbils (9.5±3.2months of age). Mean threshold elevation in the old gerbils was around 25dB at 2 and 10kHz...
November 2016: Experimental Gerontology
Kerrie Hennigan, Paul J Conroy, Marie-Therese Walsh, Mohamed Amin, Richard O'Kennedy, Patmapriya Ramasamy, Gerald J Gleich, Zeshan Siddiqui, Senan Glynn, Olive McCabe, Catherine Mooney, Brian J Harvey, Richard W Costello, Jean McBryan
Eosinophils account for 1-3% of peripheral blood leukocytes and accumulate at sites of allergic inflammation, where they play a pathogenic role. Studies have shown that treatment with mepolizumab (an anti-IL-5 monoclonal antibody) is beneficial to patients with severe eosinophilic asthma, however, the mechanism of precisely how eosinophils mediate these pathogenic effects is uncertain. Eosinophils contain several cationic granule proteins, including Eosinophil Peroxidase (EPO). The main significance of this work is the discovery of EPO as a novel ligand for the HER2 receptor...
October 2016: Clinical Immunology: the Official Journal of the Clinical Immunology Society
Stephen J Gleich, Michael E Nemergut, Anthony A Stans, Dawit T Haile, Scott A Feigal, Angela L Heinrich, Christopher L Bosley, Sandeep Tripathi
BACKGROUND AND OBJECTIVES: Ineffective and inefficient patient transfer processes can increase the chance of medical errors. Improvements in such processes are high-priority local institutional and national patient safety goals. At our institution, nonintubated postoperative pediatric patients are first admitted to the postanesthesia care unit before transfer to the PICU. This quality improvement project was designed to improve the patient transfer process from the operating room (OR) to the PICU...
August 2016: Hospital Pediatrics
Austin R Benson, David F Gleich, Jure Leskovec
Networks are a fundamental tool for understanding and modeling complex systems in physics, biology, neuroscience, engineering, and social science. Many networks are known to exhibit rich, lower-order connectivity patterns that can be captured at the level of individual nodes and edges. However, higher-order organization of complex networks--at the level of small network subgraphs--remains largely unknown. Here, we develop a generalized framework for clustering networks on the basis of higher-order connectivity patterns...
July 8, 2016: Science
Stephen J Gleich, Kim Strupp, Robert T Wilder, Daryl J Kor, Randall Flick
BACKGROUND: Malignant hyperthermia (MH) is a rare anesthetic pharmacogenetic disorder that can be difficult to detect in its earliest phases. Prompt treatment is known to improve outcomes. The modern anesthesia information management systems (AIMS) collect enormous amounts of data. However, data lack context and are not able to provide real-time guidance. Utilizing our AIMS, we developed the capacity to incorporate decision support. AIMS: We describe the creation and evaluation of a real-time detection tool for MH...
September 2016: Paediatric Anaesthesia
Abhijai Singh, Samaher Hashim, Preetam Bollampally, Mariann Padron Gleich
No abstract text is available yet for this article.
October 2016: American Journal of Medicine
Sabine Gleich, Stefan Schweitzer, Sibylle Viehöver
No abstract text is available yet for this article.
June 9, 2016: MMW Fortschritte der Medizin
Inge Schmitz, Oleg Prymak, Matthias Epple, Carsten Ernert, Andrea Tannapfel
HINTERGRUND UND ZIELE: Obwohl Tätowierungen in den letzten Jahren außerordentlich beliebt geworden sind, wurde in der Literatur bisher nur über wenige Fälle schwerer Reaktionen berichtet, die zu einer malignen Transformation führten. Dies steht im Kontrast zu der praktisch unüberschaubaren Zahl an Tätowierungen weltweit. Die Zusammensetzung der für Tätowierungen verwendeten Farbstoffe variiert stark, und selbst gleiche Farbtöne können unterschiedliche Komponenten enthalten...
June 2016: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
Hedieh Saffari, Kristin M Leiferman, Frederic Clayton, Krista Baer, Leonard F Iii Pease, Gerald J Gleich, Kathryn A Peterson
OBJECTIVES: We describe a simple, quick method to measure an eosinophil granule protein, eosinophil peroxidase (EPO), as a marker of eosinophil activity, in eosinophilic esophagitis (EoE). METHODS: Esophageal mucosal brushings initially were collected from 36 patients with active EoE (n=13), resolved EoE (n=13), and controls (n=10) before endoscopic biopsy collection; the brushes were frozen at -80 ºC until assayed. EPO on the brush was measured in a colorimetric assay visually and by spectrophotometric absorbance measurements (at 492 nm), and was compared with peak eosinophil counts in esophageal biopsy specimens...
July 2016: American Journal of Gastroenterology
Diana Raufelder, Rebecca Boehme, Lydia Romund, Sabrina Golde, Robert C Lorenz, Tobias Gleich, Anne Beck
This multi-methodological study applied functional magnetic resonance imaging to investigate neural activation in a group of adolescent students (N = 88) during a probabilistic reinforcement learning task. We related patterns of emerging brain activity and individual learning rates to socio-motivational (in-)dependence manifested in four different motivation types (MTs): (1) peer-dependent MT, (2) teacher-dependent MT, (3) peer-and-teacher-dependent MT, (4) peer-and-teacher-independent MT. A multinomial regression analysis revealed that the individual learning rate predicts students' membership to the independent MT, or the peer-and-teacher-dependent MT...
2016: Frontiers in Psychology
Joshua J Clark, Aaron M Secrest, Christopher M Hull, Mark J Eliason, Kristin M Leiferman, Gerald J Gleich, Douglas L Powell
No abstract text is available yet for this article.
June 2016: Journal of the American Academy of Dermatology
Danqing Hu, Randall P Flick, Stephen J Gleich, Maura M Scanlon, Michael J Zaccariello, Robert C Colligan, Slavica K Katusic, Darrell R Schroeder, Andrew C Hanson, Shonie L Buenvenida, Robert T Wilder, Juraj Sprung, David O Warner
Exposure to general anesthesia at an early age has been associated with adverse neurodevelopmental outcomes in both animal and human studies, but some of these studies employed anesthetic agents that are no longer in clinical use. In this manuscript, we describe the methods used to construct a new population-based study cohort to study the association between early anesthetic exposure and subsequent neurodevelopmental outcomes. A birth cohort of all children born in Olmsted County, MN from January 1, 1996 to December 31, 2000 was identified...
2016: PloS One
Alexander Gleich, Bastian Kaiser, Julia Schumann, Herbert Fuhrmann
Due to lack of in vitro models for bovine hepatocytes apart from primary cells, there is demand for a bovine hepatocyte-derived cell line. Transduction of bovine foetal hepatocytes with SV40 large T-antigen was performed using the vector pRetro-E2 SV40. Phase contrast microscopy was carried out to evaluate morphology. Immunofluorescence staining was conducted to study expression of keratins, tight junction proteins zona occludens-1 and claudin-1, glucose transporter-2 and P-glycoprotein as well as phosphoenolpyruvate carboxykinase...
June 2016: In Vitro Cellular & Developmental Biology. Animal
Nils Nothnagel, Jurgen Rahmer, Bernhard Gleich, Aleksi Halkola, Thorsten Buzug, Joern Borgert
Small magnetic devices have been steered in arbitrary direction and with variable force using a preclinical demonstrator system for magnetic particle imaging (MPI). Fast localization due to the high imaging rate of over 40 volumes per second and strong forces due to the high field gradient of more than 1 T/m render an MPI system a good platform for image-guided steering of magnetic devices. In this paper, these capabilities are demonstrated in phantom experiments, where a closed feedback loop has been realized to exert translational forces in horizontal and vertical direction on a magnetic device moving in a viscous medium...
February 2, 2016: IEEE Transactions on Bio-medical Engineering
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