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https://www.readbyqxmd.com/read/28514601/mepolizumab-or-placebo-for-eosinophilic-granulomatosis-with-polyangiitis
#1
Michael E Wechsler, Praveen Akuthota, David Jayne, Paneez Khoury, Amy Klion, Carol A Langford, Peter A Merkel, Frank Moosig, Ulrich Specks, Maria C Cid, Raashid Luqmani, Judith Brown, Stephen Mallett, Richard Philipson, Steve W Yancey, Jonathan Steinfeld, Peter F Weller, Gerald J Gleich
BACKGROUND: Eosinophilic granulomatosis with polyangiitis is an eosinophilic vasculitis. Mepolizumab, an anti-interleukin-5 monoclonal antibody, reduces blood eosinophil counts and may have value in the treatment of eosinophilic granulomatosis with polyangiitis. METHODS: In this multicenter, double-blind, parallel-group, phase 3 trial, we randomly assigned participants with relapsing or refractory eosinophilic granulomatosis with polyangiitis who had received treatment for at least 4 weeks and were taking a stable prednisolone or prednisone dose to receive 300 mg of mepolizumab or placebo, administered subcutaneously every 4 weeks, plus standard care, for 52 weeks...
May 18, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28478919/pharyngeal-mucosa-brushing-does-not-correlate-with-disease-activity-in-patients-with-eosinophilic-esophagitis
#2
Hedieh Saffari, Krista Baer, Kathleen K Boynton, Gerald J Gleich, Kathryn A Peterson
No abstract text is available yet for this article.
May 3, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28475562/leukocyte-adhesion-as-an-indicator-of-oxygenator-thrombosis-during-extracorporeal-membrane-oxygenation-therapy
#3
Julius Wilm, Alois Philipp, Thomas Müller, Andre Bredthauer, Otto Gleich, Christof Schmid, Karla Lehle
Thrombosis is the most common technical complication with extracorporeal membrane oxygenation (ECMO). Accumulations of leukocytes on the gas exchange membranes within a membrane oxygenator (MO) may initiate thrombosis and influence outcome. MOs (n = 41) were removed routinely from adult patients on ECMO, preserved, and analyzed for their cellular deposits using nuclear (4',6-diamidino-2-phenylindole) and cell type-specific markers (CD45; von Willebrand factor, vWF). The extent of cellular colonization was correlated with patient data...
May 4, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28432171/ascites-in-a-patient-with-episodic-angio-oedema-and-eosinophilia-thinking-outside-the-box
#4
Eirini I Rigopoulou, Maria Ioannou, Georgia Papadamou, Georgios N Dalekos
Episodic angio-oedema with eosinophilia (EAE) or Gleich's syndrome is a rare condition characterised by recurrent episodes of oedema and eosinophilia, accompanied by urticaria, fever and weight gain. The presence of ascites has not been reported so far. We report a 21-year-old Caucasian woman who presented with marked ocular oedema and ascites. Laboratory evaluation revealed marked eosinophilia. During the last 3 months, three episodes of facial and neck oedema were reported, which resolved spontaneously over a period of 3-5 days...
April 21, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28398211/influence-of-the-pump-pulse-wavelength-on-the-ultrafast-demagnetization-of-gd-0001-thin-films
#5
Kamil Bobowski, Markus Gleich, Niko Pontius, Christian Schuessler-Langeheine, Christoph Trabant, Marko Wietstruk, Björn Frietsch, Martin Weinelt
We studied the magnetization dynamics of gadolinium metal after femtosecond laser excitation recording the X-ray magnetic circular dichroism in reflection (XMCD-R) at the Gd $M_5$ absorption edge. Varying the photon energy of the pump pulse allows us to change the initial energy distribution of photoexcited carriers. The overall similar response for excitation with 0.95, 1.55 and 3.10\,eV photons at comparable pump fluences indicates that ultrafast ballistic carrier transport leads to a homogeneous energy distribution on the femtosecond timescale in the probed sample volume...
April 11, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28323159/functional-changes-in-the-reward-circuit-in-response-to-gaming-related-cues-after-training-with-a-commercial-video-game
#6
Tobias Gleich, Robert C Lorenz, Jürgen Gallinat, Simone Kühn
In the present longitudinal study, we aimed to investigate video game training associated neuronal changes in reward processing using functional magnetic resonance imaging (fMRI). We recruited 48 healthy young participants which were assigned to one of 2 groups: A group in which participants were instructed to play a commercial video game ("Super Mario 64 DS") on a portable Nintendo DS handheld console at least 30minutes a day over a period of two months (video gaming group; VG) or to a matched passive control group (CG)...
March 18, 2017: NeuroImage
https://www.readbyqxmd.com/read/28287965/interactive-magnetic-catheter-steering-with-3d-real-time-feedback-using-multi-color-magnetic-particle-imaging
#7
Jurgen Rahmer, Daniel Wirtz, Claas Bontus, Joern Borgert, Bernhard Gleich
method that enables sensitive and fast imaging. It does not require ionizing radiation and thus may be a safe alternative for tracking of devices in the catheterization laboratory. The 3D real-time imaging capabilities of MPI have been demonstrated in vivo and recent improvements in fast online image reconstruction enable almost real-time data reconstruction and visualization. Moreover, based on the use of different magnetic particle types for catheter visualization and blood pool imaging, multi-color MPI enables reconstruction of separate images for the catheter and the vessels from simultaneously measured data...
March 7, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28200073/aptrank-an-adaptive-pagerank-model-for-protein-function-prediction-on-bi-relational-graphs
#8
Biaobin Jiang, Kyle Kloster, David F Gleich, Michael Gribskov
No abstract text is available yet for this article.
February 14, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28195568/military-deployment-correlates-with-smaller-prefrontal-gray-matter-volume-and-psychological-symptoms-in-a-subclinical-population
#9
O Butler, J Adolf, T Gleich, G Willmund, P Zimmermann, U Lindenberger, J Gallinat, S Kühn
Research investigating the effects of trauma exposure on brain structure and function in adults has mainly focused on post-traumatic stress disorder (PTSD), whereas trauma-exposed individuals without a clinical diagnoses often serve as controls. However, this assumes a dichotomy between clinical and subclinical populations that may not be supported at the neural level. In the current study we investigate whether the effects of repeated or long-term stress exposure on brain structure in a subclinical sample are similar to previous PTSD neuroimaging findings...
February 14, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28181544/mono-energy-coronary-angiography-with-a-compact-synchrotron-source
#10
Elena Eggl, Korbinian Mechlem, Eva Braig, Stephanie Kulpe, Martin Dierolf, Benedikt Günther, Klaus Achterhold, Julia Herzen, Bernhard Gleich, Ernst Rummeny, Peter B Noёl, Franz Pfeiffer, Daniela Muenzel
X-ray coronary angiography is an invaluable tool for the diagnosis of coronary artery disease. However, the use of iodine-based contrast media can be contraindicated for patients who present with chronic renal insufficiency or with severe iodine allergy. These patients could benefit from a reduced contrast agent concentration, possibly achieved through application of a mono-energetic x-ray beam. While large-scale synchrotrons are impractical for daily clinical use, the technology of compact synchrotron sources strongly advanced during the last decade...
February 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28110087/internal-and-external-attention-and-the-default-mode-network
#11
Hannah J Scheibner, Carsten Bogler, Tobias Gleich, John-Dylan Haynes, Felix Bermpohl
Focused attention meditations have been shown to improve psychological health and wellbeing and are nowadays an integral part of many psychotherapies. While research on the neural correlates of focused attention meditation is increasing, findings vary on whether meditations are associated with high or low activity in the default mode network (DMN). To clarify the relationship between focused attention meditation and the activity in DMN regions, it may be helpful to distinguish internal and external attention as well as different phases within one meditation: During focused attention meditation, the practitioner switches between mindful attention, mind-wandering and refocusing...
March 1, 2017: NeuroImage
https://www.readbyqxmd.com/read/28099287/anesthetic-outcomes-of-children-with-arthrogryposis-syndromes-no-evidence-of-hyperthermia
#12
Stephen J Gleich, Michael Tien, Darrell R Schroeder, Andrew C Hanson, Randall Flick, Michael E Nemergut
BACKGROUND: Arthrogryposis syndromes are a heterogeneous group of disorders characterized by congenital joint contractures often requiring multiple surgeries during childhood to address skeletal and visceral abnormalities. Previous reports suggest that these children have increased perioperative risk, including hypermetabolic events discrete from malignant hyperthermia, difficult airway management, isolated hyperthermia, and difficult IV line placement. We sought to compare children with arthrogryposis multiplex congenita (AMC) versus the less severe, distal arthrogryposis syndromes (DAS) and to evaluate possible intraoperative hyperthermia of patients with AMC...
March 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28052271/establishment-and-characterization-of-an-sv40-large-t-antigen-transduced-porcine-colonic-epithelial-cell-line
#13
Bastian Kaiser, Martina Böttner, Thilo Wedel, Ronald M Brunner, Tom Goldammer, Szilvia Lesko, Gotthold Gäbel, Alexander Gleich, Helga Pfannkuche
Continuous cell lines have become indispensable tools that have enabled investigations into cellular mechanisms by increasing experimental reproducibility and sample availability, and decreasing the use of experimental animals. To facilitate studies of epithelial barrier function of the porcine colon, we aimed to establish an epithelial cell line with an extended replicative capacity. Cells were isolated from the proximal colon of a 3-week-old piglet and transduced using a recombinant retroviral vector construct containing the simian virus 40 large T antigen (SV40 TAg)...
2017: Cells, Tissues, Organs
https://www.readbyqxmd.com/read/28042335/targeting-of-magnetic-nanoparticle-coated-microbubbles-to-the-vascular-wall-empowers-site-specific-lentiviral-gene-delivery-in-vivo
#14
Yvonn Heun, Staffan Hildebrand, Alexandra Heidsieck, Bernhard Gleich, Martina Anton, Joachim Pircher, Andrea Ribeiro, Olga Mykhaylyk, Dietmar Eberbeck, Daniela Wenzel, Alexander Pfeifer, Markus Woernle, Florian Krötz, Ulrich Pohl, Hanna Mannell
In the field of vascular gene therapy, targeting systems are promising advancements to improve site-specificity of gene delivery. Here, we studied whether incorporation of magnetic nanoparticles (MNP) with different magnetic properties into ultrasound sensitive microbubbles may represent an efficient way to enable gene targeting in the vascular system after systemic application. Thus, we associated novel silicon oxide-coated magnetic nanoparticle containing microbubbles (SO-Mag MMB) with lentiviral particles carrying therapeutic genes and determined their physico-chemical as well as biological properties compared to MMB coated with polyethylenimine-coated magnetic nanoparticles (PEI-Mag MMB)...
2017: Theranostics
https://www.readbyqxmd.com/read/27851470/1835-super-refractory-status-epilepticus-in-a-teenage-boy-management-and-complications
#15
Brenda Schiltz, Eric Payne, Stephen Gleich, Yves Ouellette
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27815390/kv1-3-channels-mark-functionally-competent-cd8-tumor-infiltrating-lymphocytes-in-head-and-neck-cancer
#16
Ameet A Chimote, Peter Hajdu, Alexandros M Sfyris, Brittany N Gleich, Trisha Wise-Draper, Keith A Casper, Laura Conforti
Tumor-infiltrating lymphocytes (TIL) are potent mediators of an antitumor response. However, their function is attenuated in solid tumors. CD8(+) T-cell effector functions, such as cytokine and granzyme production, depend on cytoplasmic Ca(2+), which is controlled by ion channels. In particular, Kv1.3 channels regulate the membrane potential and Ca(2+) influx in human effector memory T (TEM) cells. In this study, we assessed the contribution of reduced Kv1.3 and Ca(2+) flux on TIL effector function in head and neck cancer (HNC)...
January 1, 2017: Cancer Research
https://www.readbyqxmd.com/read/27778084/-antibiotic-consumption-surveillance-state-of-implementation-in-munich-hospitals-latest-survey-by%C3%A2-the-munich-public-health-department-on-the-implementation-of-%C3%A2-%C3%A2-23-infection-protection-act
#17
Cornelia Otto, Bertrand Hirl, Stefan Schweitzer, Sabine Gleich
BACKGROUND: On 4 August 2011 a modification of the infection protection act became law, meaning that antibiotic consumption surveillance and evaluation of data on the local resistance situation became obligatory for hospitals. Four years after the modification of the infection protection act became law, the Munich public health department aimed to evaluate the state of implementation of antibiotic consumption surveillance in Munich hospitals and to ascertain which antibiotic stewardship (ABS) structures have already been established...
December 2016: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/27757740/design-and-%C3%AE-testing-of-an-electronic-rounding-tool-certainp-to-improve-process-of-care-in-pediatric-intensive-care-unit
#18
Manasi Hulyalkar, Stephen J Gleich, Rahul Kashyap, Amelia Barwise, Harsheen Kaur, Yue Dong, Lei Fan, Srinivas Murthy, Grace M Arteaga, Sandeep Tripathi
Increasing process complexity in the pediatric intensive care unit (PICU) can lead to information overload resulting in missing pertinent information and potential errors during morning rounds. An efficient model using a novel electronic rounding tool was designed as part of a broader critical care decision support system-checklist for early recognition and treatment of acute illness and injury in pediatrics (CERTAINp). We aimed to evaluate its impact on improving the process of care during rounding. Prospective pre- and post-interventional data included: team performance baseline assessment, patient safety discussion, guideline adherence, rounding time, and a survey of Residents' and Nurses' perception using a Likert scale...
October 18, 2016: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/27726253/neural-correlates-of-the-self-concept-in-adolescence-a-focus-on-the-significance-of-friends
#19
Lydia Romund, Sabrina Golde, Robert C Lorenz, Diana Raufelder, Patricia Pelz, Tobias Gleich, Andreas Heinz, Anne Beck
The formation of a coherent and unified self-concept represents a key developmental stage during adolescence. Imaging studies on self-referential processing in adolescents are rare, and it is not clear whether neural structures involved in self-reflection are also involved in reflections of familiar others. In the current study, 41 adolescents were asked to make judgments about trait adjectives during functional magnetic resonance imaging (fMRI): they had to indicate whether the word describes themselves, their friends, their teachers or politicians...
October 11, 2016: Human Brain Mapping
https://www.readbyqxmd.com/read/27667178/improvement-of-vascular-function-by-magnetic-nanoparticle-assisted-circumferential-gene-transfer-into-the-native-endothelium
#20
Sarah Vosen, Sarah Rieck, Alexandra Heidsieck, Olga Mykhaylyk, Katrin Zimmermann, Christian Plank, Bernhard Gleich, Alexander Pfeifer, Bernd K Fleischmann, Daniela Wenzel
Gene therapy is a promising approach for chronic disorders that require continuous treatment such as cardiovascular disease. Overexpression of vasoprotective genes has generated encouraging results in animal models, but not in clinical trials. One major problem in humans is the delivery of sufficient amounts of genetic vectors to the endothelium which is impeded by blood flow, whereas prolonged stop-flow conditions impose the risk of ischemia. In the current study we have therefore developed a strategy for the efficient circumferential lentiviral gene transfer in the native endothelium under constant flow conditions...
November 10, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
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