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https://www.readbyqxmd.com/read/29563553/propagation-based-phase-contrast-x-ray-tomography-of-cochlea-using-a-compact-synchrotron-source
#1
Mareike Töpperwien, Regine Gradl, Daniel Keppeler, Malte Vassholz, Alexander Meyer, Roland Hessler, Klaus Achterhold, Bernhard Gleich, Martin Dierolf, Franz Pfeiffer, Tobias Moser, Tim Salditt
We demonstrate that phase retrieval and tomographic imaging at the organ level of small animals can be advantageously carried out using the monochromatic radiation emitted by a compact x-ray light source, without further optical elements apart from source and detector. This approach allows to carry out microtomography experiments which - due to the large performance gap with respect to conventional laboratory instruments - so far were usually limited to synchrotron sources. We demonstrate the potential by mapping the functional soft tissue within the guinea pig and marmoset cochlea, including in the latter case an electrical cochlear implant...
March 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29532559/epidemiology-of-general-anesthesia-prior-to-age-3-in-a-population-based-birth-cohort
#2
Yu Shi, Danqing Hu, Erin L Rodgers, Slavica K Katusic, Stephen J Gleich, Andrew C Hanson, Darrell R Schroeder, Randall P Flick, David O Warner
BACKGROUND: Utilization of general anesthesia in children has important policy, economic, and healthcare delivery implications, yet there is little information regarding the epidemiology of these procedures in the United States. AIMS: The primary objective of this study was to describe in a geographically defined population the incidence of procedures requiring general anesthesia up to the child's third birthday, and the patient characteristics associated with receiving these procedures...
March 13, 2018: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/29494647/remote-magnetic-actuation-using-a-clinical-scale-system
#3
Jürgen Rahmer, Christian Stehning, Bernhard Gleich
Remote magnetic manipulation is a powerful technique for controlling devices inside the human body. It enables actuation and locomotion of tethered and untethered objects without the need for a local power supply. In clinical applications, it is used for active steering of catheters in medical interventions such as cardiac ablation for arrhythmia treatment and for steering of camera pills in the gastro-intestinal tract for diagnostic video acquisition. For these applications, specialized clinical-scale field applicators have been developed, which are rather limited in terms of field strength and flexibility of field application...
2018: PloS One
https://www.readbyqxmd.com/read/29388825/perfectionistic-cognitions-stability-variability-and-changes-over-time
#4
Elisabeth Prestele, Christine Altstötter-Gleich
The construct of perfectionistic cognitions is defined as a state-like construct resulting from a perfectionistic self-schema and activated by specific situational demands. Only a few studies have investigated whether and how perfectionistic cognitions change across different situations and whether they reflect stable between-person differences or also within-person variations over time. We conducted 2 studies to investigate the variability and stability of 3 dimensions of perfectionistic cognitions while situational demands changed (Study 1) and on a daily level during a highly demanding period of time (Study 2)...
February 1, 2018: Journal of Personality Assessment
https://www.readbyqxmd.com/read/29371617/risks-release-and-concentrations-of-engineered-nanomaterial-in-the-environment
#5
Bernd Giese, Fred Klaessig, Barry Park, Ralf Kaegi, Michael Steinfeldt, Henning Wigger, Arnim von Gleich, Fadri Gottschalk
For frequently used engineered nanomaterials (ENMs) CeO2-, SiO2-, and Ag, past, current, and future use and environmental release are investigated. Considering an extended period (1950 to 2050), we assess ENMs released through commercial activity as well as found in natural and technical settings. Temporal dynamics, including shifts in release due to ENM product application, stock (delayed use), and subsequent end-of-life product treatment were taken into account. We distinguish predicted concentrations originating in ENM use phase and those originating from end-of-life release...
January 25, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29361641/-surveillance-of-supervised-flat-sharing-communities-requiring-intensive-home-care-results-and-conclusions
#6
Leila Horvath, Doris Böhm, Sabine Gleich
BACKGROUND: Patients with intensive care and long-term mechanical ventilation needs are increasingly cared for in supervised flat-sharing communities. The municipal public health and environment department of Munich audited nursing services between April 2015 and August 2016. METHODS: The structural analysis of the nursing services was conducted using standardised checklists, and statistical analysis was performed. In agreement with the residents and providers of the nursing service, flats were inspected...
January 23, 2018: Das Gesundheitswesen
https://www.readbyqxmd.com/read/29251365/investigations-of-the-copper-catalyzed-oxidative-cross-coupling-of-tetrahydroisoquinolines-with-diethylzinc-by-a-combination-of-mass-spectrometric-and-electrochemical-methods
#7
J Alexander Willms, Hermann Gleich, Michael Schrempp, Dirk Menche, Marianne Engeser
The aerobic oxidative cross-coupling of tetrahydroisoquinolines (THIQs) with diethylzinc catalyzed by CuCl2 has been examined by means of electrospray mass spectrometry (ESI-MS). Substrates, intermediates, and the product were readily detected. Particular emphasis has been placed on the role of CuCl2 . Formation of the intermediate iminium species has been investigated in more detail by ESI-MS, electrochemistry-coupled ESI mass spectrometry (EC-MS), and cyclic voltammetry (CV). Our experiments have consistently revealed strong influences of the N-substituent of the THIQ derivative and its oxidation stability with respect to CuCl2 ...
February 21, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29179133/improved-heart-repair-upon-myocardial-infarction-combination-of-magnetic-nanoparticles-and-tailored-magnets-strongly-increases-engraftment-of-myocytes
#8
Annika Ottersbach, Olga Mykhaylyk, Alexandra Heidsieck, Dietmar Eberbeck, Sarah Rieck, Katrin Zimmermann, Martin Breitbach, Britta Engelbrecht, Tobias Brügmann, Michael Hesse, Armin Welz, Philipp Sasse, Daniela Wenzel, Christian Plank, Bernhard Gleich, Michael Hölzel, Wilhelm Bloch, Alexander Pfeifer, Bernd K Fleischmann, Wilhelm Roell
Cell replacement in the heart is considered a promising strategy for the treatment of post-infarct heart failure. Direct intramyocardial injection of cells proved to be the most effective application route, however, engraftment rates are very low (<5%) strongly hampering its efficacy. Herein we combine magnetic nanoparticle (MNP) loading of EGFP labeled embryonic cardiomyocytes (eCM) and embryonic stem cell-derived cardiomyocytes (ES-CM) with application of custom designed magnets to enhance their short and long-term engraftment...
February 2018: Biomaterials
https://www.readbyqxmd.com/read/29109262/myoanatomy-of-the-velvet-worm-leg-revealed-by-laboratory-based-nanofocus-x-ray-source-tomography
#9
Mark Müller, Ivo de Sena Oliveira, Sebastian Allner, Simone Ferstl, Pidassa Bidola, Korbinian Mechlem, Andreas Fehringer, Lorenz Hehn, Martin Dierolf, Klaus Achterhold, Bernhard Gleich, Jörg U Hammel, Henry Jahn, Georg Mayer, Franz Pfeiffer
X-ray computed tomography (CT) is a powerful noninvasive technique for investigating the inner structure of objects and organisms. However, the resolution of laboratory CT systems is typically limited to the micrometer range. In this paper, we present a table-top nanoCT system in conjunction with standard processing tools that is able to routinely reach resolutions down to 100 nm without using X-ray optics. We demonstrate its potential for biological investigations by imaging a walking appendage of Euperipatoides rowelli , a representative of Onychophora-an invertebrate group pivotal for understanding animal evolution...
November 21, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29101369/trabecular-bone-anisotropy-imaging-with-a-compact-laser-undulator-synchrotron-x-ray-source
#10
Christoph Jud, Eva Braig, Martin Dierolf, Elena Eggl, Benedikt Günther, Klaus Achterhold, Bernhard Gleich, Ernst Rummeny, Peter Noël, Franz Pfeiffer, Daniela Muenzel
Conventional x-ray radiography is a well-established standard in diagnostic imaging of human bones. It reveals typical bony anatomy with a strong surrounding cortical bone and trabecular structure of the inner part. However, due to limited spatial resolution, x-ray radiography cannot provide information on the microstructure of the trabecular bone. Thus, microfractures without dislocation are often missed in initial radiographs, resulting in a lack or delay of adequate therapy. Here we show that x-ray vector radiography (XVR) can overcome this limitation and allows for a deeper insight into the microstructure with a radiation exposure comparable to standard radiography...
November 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29049300/increased-cell-survival-and-cytogenetic-integrity-by-spatial-dose-redistribution-at-a-compact-synchrotron-x-ray-source
#11
Karin Burger, Katarina Ilicic, Martin Dierolf, Benedikt Günther, Dietrich W M Walsh, Ernst Schmid, Elena Eggl, Klaus Achterhold, Bernhard Gleich, Stephanie E Combs, Michael Molls, Thomas E Schmid, Franz Pfeiffer, Jan J Wilkens
X-ray microbeam radiotherapy can potentially widen the therapeutic window due to a geometrical redistribution of the dose. However, high requirements on photon flux, beam collimation, and system stability restrict its application mainly to large-scale, cost-intensive synchrotron facilities. With a unique laser-based Compact Light Source using inverse Compton scattering, we investigated the translation of this promising radiotherapy technique to a machine of future clinical relevance. We performed in vitro colony-forming assays and chromosome aberration tests in normal tissue cells after microbeam irradiation compared to homogeneous irradiation at the same mean dose using 25 keV X-rays...
2017: PloS One
https://www.readbyqxmd.com/read/29047321/perioperative-and-anesthetic-considerations-in-pulmonary-atresia-with-intact-ventricular-septum
#12
Stephen Gleich, Gregory J Latham, Denise Joffe, Faith J Ross
Pulmonary atresia with intact ventricular septum (PA/IVS) is a rare right-heart obstructive lesion with a wide anatomic and physiologic spectrum of disease, ranging from simple membranous pulmonary valve atresia with a fully developed right ventricle (RV) to a severely hypoplastic RV and ventriculocoronary (RV-coronary) fistulas. Affected neonates are dependent on prostaglandin for adequate pulmonary blood flow. Depending on the severity of disease, treatment options range from transcatheter pulmonary valve perforation and ultimate biventricular repair to staged single-ventricle palliation...
October 1, 2017: Seminars in Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29037509/structure-determination-of-disease-associated-peak-aaa-from-l-tryptophan-implicated-in-the-eosinophilia-myalgia-syndrome
#13
Klaus Klarskov, Hugo Gagnon, Pierre-Luc Boudreault, Chad Normandin, Baptiste Plancq, Eric Marsault, Gerald J Gleich, Stephen Naylor
The eosinophilia-myalgia syndrome (EMS) outbreak of 1989 that occurred in the USA and elsewhere was caused by the ingestion of l-Tryptophan (L-Trp) solely manufactured by the Japanese company Showa Denko K.K. (SD). Six compounds present in the SD L-Trp were reported to be case-associated contaminants. However, "one" of these compounds, Peak AAA has remained structurally uncharacterized, despite the fact that it was described as "the only statistically significant (p=0.0014) contaminant"...
January 5, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/28902608/technique-tricks-for-the-gleich-koutsogiannis-surgical-procedure-for-correction-of-the-adult-acquired-flatfoot
#14
Andrea Salvi, Andrea Volghi
Gleich-Koutsogiannis is a widely known extra-articular closing calcaneal osteotomic technique for correction of the adult flatfoot. Absolute care must be observed during each procedural step to avoid undesirable drawbacks, such as nerves and tendons lesions, incorrect fixation, and hardware painful prominence. It is the purpose of this report to introduce tricks to critical steps in order to improve the technique and minimize potential surgical complications.
May 2017: Bulletin of the Hospital for Joint Diseases
https://www.readbyqxmd.com/read/28852777/-clostridium-difficile-associated-deaths-from-2013-2016-in-munich-and-nuremberg-reporting-behavior-and-patient-characteristics
#15
REVIEW
Sabine Gleich, Alice Schaffer, Cam Hong Mai, Sylvia Schick, Bertrand Hirl
BACKGROUND: A number of risk factors for C. difficile infection (CDI) are described in the literature, in particular an antibiotic therapy 4-6 weeks before disease, an age of >65 years, immunosuppression and living in a long-term care facility. Increasing incidence rates have been reported for Germany. CDI is the fourth most common nosocomial infection with 6.4%. AIM: Due to the amendment of the Infection Protection Act of 01.05.2016, the proportion of all deaths that are C...
October 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/28687726/propagation-based-phase-contrast-x-ray-imaging-at-a-compact-light-source
#16
Regine Gradl, Martin Dierolf, Lorenz Hehn, Benedikt Günther, Ali Önder Yildirim, Bernhard Gleich, Klaus Achterhold, Franz Pfeiffer, Kaye Susannah Morgan
We demonstrate the applicability of propagation-based X-ray phase-contrast imaging at a laser-assisted compact light source with known phantoms and the lungs and airways of a mouse. The Munich Compact Light Source provides a quasi-monochromatic beam with partial spatial coherence, and high flux relative to other non-synchrotron sources (up to 10(10) ph/s). In our study we observe significant edge-enhancement and quantitative phase-retrieval is successfully performed on the known phantom. Furthermore the images of a small animal show the potential for live bio-imaging research studies that capture biological function using short exposures...
July 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28684858/in-vivo-x-ray-dark-field-chest-radiography-of-a-pig
#17
Lukas B Gromann, Fabio De Marco, Konstantin Willer, Peter B Noël, Kai Scherer, Bernhard Renger, Bernhard Gleich, Klaus Achterhold, Alexander A Fingerle, Daniela Muenzel, Sigrid Auweter, Katharina Hellbach, Maximilian Reiser, Andrea Baehr, Michaela Dmochewitz, Tobias J Schroeter, Frieder J Koch, Pascal Meyer, Danays Kunka, Juergen Mohr, Andre Yaroshenko, Hanns-Ingo Maack, Thomas Pralow, Hendrik van der Heijden, Roland Proksa, Thomas Koehler, Nataly Wieberneit, Karsten Rindt, Ernst J Rummeny, Franz Pfeiffer, Julia Herzen
X-ray chest radiography is an inexpensive and broadly available tool for initial assessment of the lung in clinical routine, but typically lacks diagnostic sensitivity for detection of pulmonary diseases in their early stages. Recent X-ray dark-field (XDF) imaging studies on mice have shown significant improvements in imaging-based lung diagnostics. Especially in the case of early diagnosis of chronic obstructive pulmonary disease (COPD), XDF imaging clearly outperforms conventional radiography. However, a translation of this technique towards the investigation of larger mammals and finally humans has not yet been achieved...
July 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28619060/incidence-disease-onset-and-short-term-outcome-in-urea-cycle-disorders-cross-border-surveillance-in-germany-austria-and-switzerland
#18
Susanne Nettesheim, Stefan Kölker, Daniela Karall, Johannes Häberle, Roland Posset, Georg F Hoffmann, Beate Heinrich, Florian Gleich, Sven F Garbade
BACKGROUND: Urea cycle disorders (UCDs) are a group of rare inherited metabolic disorders. Affected individuals often present with hyperammonemic encephalopathy (HE) and have an increased risk of severe neurologic disease and early death. The study aims to provide epidemiologic data and to describe the disease manifestation and short-term outcome. METHOD: Cross-border surveillance of newly diagnosed patients with UCDs - below 16 years of age - was performed from July 2012 to June 2015 in Germany and Austria and from January 2012 to December 2015 in Switzerland...
June 15, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/28609302/association-between-exposure-of-young-children-to-procedures-requiring-general-anesthesia-and-learning-and-behavioral-outcomes-in-a-population-based-birth-cohort
#19
Danqing Hu, Randall P Flick, Michael J Zaccariello, Robert C Colligan, Slavica K Katusic, Darrell R Schroeder, Andrew C Hanson, Shonie L Buenvenida, Stephen J Gleich, Robert T Wilder, Juraj Sprung, David O Warner
BACKGROUND: Exposure of young animals to general anesthesia causes neurodegeneration and lasting behavioral abnormalities; whether these findings translate to children remains unclear. This study used a population-based birth cohort to test the hypothesis that multiple, but not single, exposures to procedures requiring general anesthesia before age 3 yr are associated with adverse neurodevelopmental outcomes. METHODS: A retrospective study cohort was assembled from children born in Olmsted County, Minnesota, from 1996 to 2000 (inclusive)...
August 2017: Anesthesiology
https://www.readbyqxmd.com/read/28604579/how-to-avoid-a-learning-curve-in-stapedotomy-a-standardized-surgical-technique
#20
Pingling Kwok, Otto Gleich, Katharina Dalles, Elisabeth Mayr, Peter Jacob, Jürgen Strutz
OBJECTIVE: To evaluate, whether a learning curve for beginners in stapedotomy can be avoided by using a prosthesis with thermal memory-shape attachment in combination with a standardized laser-assisted surgical technique. STUDY DESIGN: Retrospective case review. SETTING: Tertiary referral center. PATIENTS: Fifty-eight ears were operated by three experienced surgeons and compared with a group of 12 cases operated by a beginner in stapedotomy...
August 2017: Otology & Neurotology
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