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https://www.readbyqxmd.com/read/29642908/putative-human-sperm-interactome-a-networks-study
#1
Alessandra Ordinelli, Nicola Bernabò, Massimiliano Orsini, Mauro Mattioli, Barbara Barboni
BACKGROUND: For over sixty years, it has been known that mammalian spermatozoa immediately after ejaculation are virtually infertile. They became able to fertilize only after they reside for long time (hours to days) within female genital tract where they complete their functional maturation, the capacitation. This process is finely regulated by the interaction with the female environment and involves, in spermatozoa, a myriad of molecules as messengers and target of signals. Since, to date, a model able to represent the molecular interaction that characterize sperm physiology does not exist, we realized the Human Sperm Interactme Network3...
April 11, 2018: BMC Systems Biology
https://www.readbyqxmd.com/read/29617869/changes-in-brain-structural-networks-and-cognitive-functions-in-testicular-cancer-patients-receiving-cisplatin-based-chemotherapy
#2
Ali Amidi, S M Hadi Hosseini, Alexander Leemans, Shelli R Kesler, Mads Agerbæk, Lisa M Wu, Robert Zachariae
Background: Cisplatin-based chemotherapy may have neurotoxic effects within the central nervous system. The aims of this study were 1) to longitudinally investigate the impact of cisplatin-based chemotherapy on whole-brain networks in testicular cancer patients undergoing treatment and 2) to explore whether possible changes are related to decline in cognitive functioning. Methods: Sixty-four newly orchiectomized TC patients underwent structural magnetic resonance imaging (T1-weighted and diffusion-weighted imaging) and cognitive testing at baseline prior to further treatment and again at a six-month follow-up...
December 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29614264/spatial-correlation-as-an-early-warning-signal-of-regime-shifts-in-a-multiplex-disease-behaviour-network
#3
Peter C Jentsch, Madhur Anand, Chris T Bauch
Early warning signals of sudden regime shifts are a widely studied phenomenon for their ability to quantify a system's proximity to a tipping point to a new and contrasting dynamical regime. However, this effect has been little studied in the context of the complex interactions between disease dynamics and vaccinating behaviour. Our objective was to determine whether critical slowing down (CSD) occurs in a multiplex network that captures opinion propagation on one network layer and disease spread on a second network layer...
March 31, 2018: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/29599717/gray-matter-network-disruptions-and-regional-amyloid-beta-in-cognitively-normal-adults
#4
Mara Ten Kate, Pieter Jelle Visser, Hovagim Bakardjian, Frederik Barkhof, Sietske A M Sikkes, Wiesje M van der Flier, Philip Scheltens, Harald Hampel, Marie-Odile Habert, Bruno Dubois, Betty M Tijms
The accumulation of amyloid plaques is one of the earliest pathological changes in Alzheimer's disease (AD) and may occur 20 years before the onset of symptoms. Examining associations between amyloid pathology and other early brain changes is critical for understanding the pathophysiological underpinnings of AD. Alterations in gray matter networks might already start at early preclinical stages of AD. In this study, we examined the regional relationship between amyloid aggregation measured with positron emission tomography (PET) and gray matter network measures in elderly subjects with subjective memory complaints...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29599714/clustering-coefficients-for-correlation-networks
#5
Naoki Masuda, Michiko Sakaki, Takahiro Ezaki, Takamitsu Watanabe
Graph theory is a useful tool for deciphering structural and functional networks of the brain on various spatial and temporal scales. The clustering coefficient quantifies the abundance of connected triangles in a network and is a major descriptive statistics of networks. For example, it finds an application in the assessment of small-worldness of brain networks, which is affected by attentional and cognitive conditions, age, psychiatric disorders and so forth. However, it remains unclear how the clustering coefficient should be measured in a correlation-based network, which is among major representations of brain networks...
2018: Frontiers in Neuroinformatics
https://www.readbyqxmd.com/read/29593490/a-comparative-study-of-standardized-infinity-reference-and-average-reference-for-eeg-of-three-typical-brain-states
#6
Gaoxing Zheng, Xiaoying Qi, Yuzhu Li, Wei Zhang, Yuguo Yu
The choice of different reference electrodes plays an important role in deciphering the functional meaning of electroencephalography (EEG) signals. In recent years, the infinity zero reference using the reference electrode standard technique (REST) has been increasingly applied, while the average reference (AR) was generally advocated as the best available reference option in previous classical EEG studies. Here, we designed EEG experiments and performed a direct comparison between the influences of REST and AR on EEG-revealed brain activity features for three typical brain behavior states (eyes-closed, eyes-open and music-listening)...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29569637/towards-distribution-based-control-of-social-networks
#7
Dave McKenney, Tony White
Background: Complex networks are found in many domains and the control of these networks is a research topic that continues to draw increasing attention. This paper proposes a method of network control that attempts to maintain a specified target distribution of the network state. In contrast to many existing network control research works, which focus exclusively on structural analysis of the network, this paper also accounts for user actions/behaviours within the network control problem...
2018: Computational social networks
https://www.readbyqxmd.com/read/29543978/hyperbrain-network-properties-of-guitarists-playing-in-quartet
#8
Viktor Müller, Johanna Sänger, Ulman Lindenberger
When playing music in an ensemble, musicians need to precisely coordinate their actions with one another. As shown in our previous studies on guitar duets, interbrain synchronization plays an essential role during such interactions. In this study, we simultaneously recorded electroencephalograms from four guitarists during quartet playing, to explore the extent and the functional significance of synchronized cortical activity across four brains. We found that hyperbrain networks based on intra- and interbrain connectivity across four brains dwell on higher frequencies for intrabrain communication and on lower frequencies for interbrain connections...
March 15, 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29532350/metabolic-brain-network-analysis-of-hypothyroidism-symptom-based-on-18-f-fdg-pet-of-rats
#9
Hongkai Wang, Ziyu Tan, Qiang Zheng, Jing Yu
PURPOSE: Recent researches have demonstrated the value of using 2-deoxy-2-[18 F]fluoro-D-glucose ([18 F]FDG) positron emission tomography (PET) imaging to reveal the hypothyroidism-related damages in local brain regions. However, the influence of hypothyroidism on the entire brain network is barely studied. This study focuses on the application of graph theory on analyzing functional brain networks of the hypothyroidism symptom. PROCEDURES: For both the hypothyroidism and the control groups of Wistar rats, the functional brain networks were constructed by thresholding the glucose metabolism correlation matrices of 58 brain regions...
March 12, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29527484/alteration-of-brain-network-topology-in-hiv-associated-neurocognitive-disorder-a-novel-functional-connectivity-perspective
#10
Anas Z Abidin, Adora M DSouza, Mahesh B Nagarajan, Lu Wang, Xing Qiu, Giovanni Schifitto, Axel Wismüller
HIV is capable of invading the brain soon after seroconversion. This ultimately can lead to deficits in multiple cognitive domains commonly referred to as HIV-associated neurocognitive disorders (HAND). Clinical diagnosis of such deficits requires detailed neuropsychological assessment but clinical signs may be difficult to detect during asymptomatic injury of the central nervous system (CNS). Therefore neuroimaging biomarkers are of particular interest in HAND. In this study, we constructed brain connectivity profiles of 40 subjects (20 HIV positive subjects and 20 age-matched seronegative controls) using two different methods: a non-linear mutual connectivity analysis approach and a conventional method based on Pearson's correlation...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29526702/protein-network-module-based-identification-of-key-pharmacological-pathways-of-curcuma-phaeocaulis-val-acting-on-hepatitis
#11
Yanxiong Gan, Shichao Zheng, Jiaqi Zhao, Chen Zhang, Tianhui Gao, Wan Liao, Qiang Fu, Chaomei Fu
ETHNOPHARMACOLOGICAL RELEVANCE: Curcuma phaeocaulis Val. (CP), as the vital medicines for blood-breaking and disorder-eliminating, has been widely used for hepatitis with good curative effects. Owing to the complexity of traditional Chinese medicine, the pharmacological mechanism of CP remains unclear. To solve this problem, a protein network module-based approach was proposed in this study. MATERIALS AND METHODS: Firstly, the content of active components of CP was detected based on HPLC-DAD...
March 8, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29526226/structure-of-association-networks-in-food-bacterial-communities
#12
Eugenio Parente, Teresa Zotta, Karoline Faust, Francesca De Filippis, Danilo Ercolini
The structure of microbial association networks was investigated for seventeen studies on food bacterial communities using the CoNet app. The results were compared with those for host and environmental microbiomes. Microbial association networks of food bacterial communities shared several properties with those of host microbiomes, although they were less complex and lacked a scale-free, small world structure that is characteristic of environmental microbial communities. This may depend on both the initial contamination pattern, whose main source is the raw material microbiome, and on the copiotrophic nature of food environments, with lack of well defined, specific niches...
August 2018: Food Microbiology
https://www.readbyqxmd.com/read/29521770/it-s-a-small-world-after-all
#13
Cynthia Blank-Reid
No abstract text is available yet for this article.
March 2018: Journal of Trauma Nursing: the Official Journal of the Society of Trauma Nurses
https://www.readbyqxmd.com/read/29520641/structural-connectome-with-high-angular-resolution-diffusion-imaging-mri-assessing-the-impact-of-diffusion-weighting-and-sampling-on-graph-theoretic-measures
#14
Giuseppina Caiazzo, Michele Fratello, Federica Di Nardo, Francesca Trojsi, Gioacchino Tedeschi, Fabrizio Esposito
PURPOSE: Advances in computational network analysis have enabled the characterization of topological properties of human brain networks (connectomics) from high angular resolution diffusion imaging (HARDI) MRI structural measurements. In this study, the effect of changing the diffusion weighting (b value) and sampling (number of gradient directions) was investigated in ten healthy volunteers, with specific focus on graph theoretical network metrics used to characterize the human connectome...
March 8, 2018: Neuroradiology
https://www.readbyqxmd.com/read/29510747/the-left-frontal-cortex-supports-reserve-in-aging-by-enhancing-functional-network-efficiency
#15
Nicolai Franzmeier, Julia Hartmann, Alexander N W Taylor, Miguel Á Araque-Caballero, Lee Simon-Vermot, Lana Kambeitz-Ilankovic, Katharina Bürger, Cihan Catak, Daniel Janowitz, Claudia Müller, Birgit Ertl-Wagner, Robert Stahl, Martin Dichgans, Marco Duering, Michael Ewers
BACKGROUND: Recent evidence derived from functional magnetic resonance imaging (fMRI) studies suggests that functional hubs (i.e., highly connected brain regions) are important for mental health. We found recently that global connectivity of a hub in the left frontal cortex (LFC connectivity) is associated with relatively preserved memory abilities and higher levels of protective factors (education, IQ) in normal aging and Alzheimer's disease. These results suggest that LFC connectivity supports reserve capacity, alleviating memory decline...
March 6, 2018: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/29497372/the-influence-of-preprocessing-steps-on-graph-theory-measures-derived-from-resting-state-fmri
#16
Fatma Gargouri, Fathi Kallel, Sebastien Delphine, Ahmed Ben Hamida, Stéphane Lehéricy, Romain Valabregue
Resting state functional MRI (rs-fMRI) is an imaging technique that allows the spontaneous activity of the brain to be measured. Measures of functional connectivity highly depend on the quality of the BOLD signal data processing. In this study, our aim was to study the influence of preprocessing steps and their order of application on small-world topology and their efficiency in resting state fMRI data analysis using graph theory. We applied the most standard preprocessing steps: slice-timing, realign, smoothing, filtering, and the tCompCor method...
2018: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/29489837/how-does-language-change-as-a-lexical-network-an-investigation-based-on-written-chinese-word-co-occurrence-networks
#17
Heng Chen, Xinying Chen, Haitao Liu
Language is a complex adaptive system, but how does it change? For investigating this process, four diachronic Chinese word co-occurrence networks have been built based on texts that were written during the last 2,000 years. By comparing the network indicators that are associated with the hierarchical features in language networks, we learn that the hierarchy of Chinese lexical networks has indeed evolved over time at three different levels. The connections of words at the micro level are continually weakening; the number of words in the meso-level communities has increased significantly; and the network is expanding at the macro level...
2018: PloS One
https://www.readbyqxmd.com/read/29484269/altered-functional-networks-in-long-term-unilateral-hearing-loss-a-connectome-analysis
#18
Yanyang Zhang, Zhiqi Mao, Shiyu Feng, Xinyun Liu, Lan Lan, Jun Zhang, Xinguang Yu
Introduction: In neuroimaging studies, long-term unilateral hearing loss (UHL) is associated with functional changes in specific brain regions and connections; however, little is known regarding alterations in the topological organization of whole-brain functional networks and whether these alterations are related to hearing behavior in UHL patients. Methods: We acquired resting-state fMRI data from 21 patients with UHL caused by acoustic neuromas and 21 matched healthy controls...
February 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29477772/it-s-not-a-small-world-after-all
#19
EDITORIAL
Sheryl Zimmerman, Jenny T van der Steen
No abstract text is available yet for this article.
March 2018: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/29476170/multiscale-dynamical-network-mechanisms-underlying-aging-of-an-online-organism-from-birth-to-death
#20
M Zheng, Z Cao, Y Vorobyeva, P Manrique, C Song, N F Johnson
We present the continuous-time evolution of an online organism network from birth to death which crosses all organizational and temporal scales, from individual components through to the mesoscopic and entire system scale. These continuous-time data reveal a lifespan driven by punctuated, real-time co-evolution of the structural and functional networks. Aging sees these structural and functional networks gradually diverge in terms of their small-worldness and eventually their connectivity. Dying emerges as an extended process associated with the formation of large but disjoint functional sub-networks together with an increasingly detached core...
February 23, 2018: Scientific Reports
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