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https://www.readbyqxmd.com/read/27914760/update-clinical-use-of-plasma-lactate
#1
REVIEW
Íde Gillespie, Patricia G Rosenstein, Dez Hughes
Lactate is an essential, versatile metabolic fuel in cellular bioenergetics. In human emergency and critical care, lactate is used as a biomarker and therapeutic endpoint and evidence is growing in veterinary medicine supporting its clinical utility. Lactate production is a protective response providing ongoing cellular energy during tissue hypoperfusion or hypoxia and mitigating acidosis. Hence, hyperlactatemia is closely associated with disease severity but it is an epiphenomenon as the body attempts to protect itself...
November 30, 2016: Veterinary Clinics of North America. Small Animal Practice
https://www.readbyqxmd.com/read/27891118/colistin-in-pig-production-chemistry-mechanism-of-antibacterial-action-microbial-resistance-emergence-and-one-health-perspectives
#2
REVIEW
Mohamed Rhouma, Francis Beaudry, William Thériault, Ann Letellier
Colistin (Polymyxin E) is one of the few cationic antimicrobial peptides commercialized in both human and veterinary medicine. For several years now, colistin has been considered the last line of defense against infections caused by multidrug-resistant Gram-negative such as Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae. Colistin has been extensively used orally since the 1960s in food animals and particularly in swine for the control of Enterobacteriaceae infections. However, with the recent discovery of plasmid-mediated colistin resistance encoded by the mcr-1 gene and the higher prevalence of samples harboring this gene in animal isolates compared to other origins, livestock has been singled out as the principal reservoir for colistin resistance amplification and spread...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27828770/responding-to-a-zoonotic-emergency-with-multi-omics-research-pentatrichomonas-hominis-hydrogenosomal-protein-characterization-with-use-of-rna-sequencing-and-proteomics
#3
Yi-Kai Fang, Kun-Yi Chien, Kuo-Yang Huang, Wei-Hung Cheng, Fu-Mann Ku, Rose Lin, Ting-Wen Chen, Po-Jung Huang, Cheng-Hsun Chiu, Petrus Tang
Pentatrichomonas hominis is an anaerobic flagellated protist that colonizes the large intestine of a number of mammals, including cats, dogs, nonhuman primates, and humans. The wide host range of this organism is alarming and suggests a rising zoonotic emergency. However, knowledge on in-depth biology of this protist is still limited. Similar to the human pathogen, Trichomonas vaginalis, P. hominis possesses hydrogenosomes instead of mitochondria. Studies in T. vaginalis indicated that hydrogenosome is essential for cell survival and associated with numerous pivotal biological functions, including drug resistance...
November 2016: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/27779918/producing-interdisciplinary-competent-professionals-integrating-one-health-core-competencies-into-the-veterinary-curriculum-at-the-university-of-rwanda
#4
Hellen J Amuguni, Melissa Mazan, Robert Kibuuka
Infectious diseases of grave concern to human health are emerging from wildlife and livestock populations in multiple regions of the world. Responding effectively to these emerging pandemics requires engagement of multidisciplinary groups of professionals. Using a One Health approach, One Health Central and Eastern Africa (OHCEA), a network of seven schools of public health and seven veterinary schools, with the support of the United States Agency for International Development (USAID), has engaged in curriculum review with the aim of building the skills of multidisciplinary groups of professionals to improve their capacity to respond to emerging infectious diseases...
October 25, 2016: Journal of Veterinary Medical Education
https://www.readbyqxmd.com/read/27774428/acupuncture-combined-with-chinese-herbs-for-the-treatment-in-hemivertebral-french-bulldogs-with-emergent-paraparesis
#5
Ching Ming Liu, G Reed Holyoak, Chung Tien Lin
This study follows the treatment of six French bulldogs with paraparesis caused by congenital hemivertebra which were structurally mild but clinically severe. A standardized acupuncture ( zhēn jiǔ) treatment using Hua-Tuo-Jiaji (HTJJ) as local points and other distant points combined with Chinese herbs improved the clinical signs. Few, if any, published papers mention Traditional Chinese Veterinary Medicine (TCVM) for treatment of hemivertebral paraparesis in French bulldogs. Based on the rapid treatment outcome, we encourage practitioners to integrate this form of conservative management into emergency treatment...
October 2016: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/27752455/results-of-extended-plant-tests-using-more-realistic-exposure-scenarios-for-improving-environmental-risk-assessment-of-veterinary-pharmaceuticals
#6
Elisabeth Richter, Silvia Berkner, Ina Ebert, Bernhard Förster, Nadin Graf, Monika Herrchen, Ute Kühnen, Jörg Römbke, Markus Simon
BACKGROUND: Residues of veterinary medicinal products (VMPs) enter the environment via application of manure onto agricultural areas where in particular antibiotics can cause phytotoxicity. Terrestrial plant tests according to OECD guideline 208 are part of the environmental risk assessment of VMPs. However, this standard approach might not be appropriate for VMPs which form non-extractable residues or transformation products in manure and manure-amended soil. Therefore, a new test design with a more realistic exposure scenario via manure application is needed...
2016: Environmental Sciences Europe
https://www.readbyqxmd.com/read/27743665/the-lactococcus-genus-as-a-potential-emerging-mastitis-pathogen-group-a-report-on-an-outbreak-investigation
#7
M X Rodrigues, S F Lima, C H Higgins, S G Canniatti-Brazaca, R C Bicalho
The bacterium Lactococcus lactis is widely used in food production and in medical applications, and is considered safe for human and animal use. However, studies have also linked Lactococcus bacteria to infection. For example, certain variants of Lactococcus species have been associated with bovine mastitis (e.g., Lactococcus lactis and Lactococcus garvieae). In this study, we investigated an outbreak of bovine mastitis thought to be associated with Lactococcus bacteria by using microbiological and molecular techniques...
October 13, 2016: Journal of Dairy Science
https://www.readbyqxmd.com/read/27736928/evaluation-of-feline-renal-perfusion-with-contrast-enhanced-ultrasonography-and-scintigraphy
#8
Emmelie Stock, Katrien Vanderperren, Tim Bosmans, André Dobbeleir, Luc Duchateau, Myriam Hesta, Lien Lybaert, Kathelijne Peremans, Eva Vandermeulen, Jimmy Saunders
Contrast-enhanced ultrasound (CEUS) is an emerging technique to evaluate tissue perfusion. Promising results have been obtained in the evaluation of renal perfusion in health and disease, both in human and veterinary medicine. Renal scintigraphy using 99mTc-Mercaptoacetyltriglycine (MAG3) is another non-invasive technique that can be used to evaluate renal perfusion. However, no data are available on the ability of CEUS or 99mTc- MAG3 scintigraphy to detect small changes in renal perfusion in cats. Therefore, both techniques were applied in a normal feline population to evaluate detection possibilities of perfusion changes by angiotensin II (AT II)...
2016: PloS One
https://www.readbyqxmd.com/read/27660260/40-years-of-veterinary-papers-in-jac-what-have-we-learnt
#9
REVIEW
Stefan Schwarz, Virve I Enne, Engeline van Duijkeren
This review, for the occasion of the 40th anniversary of the Journal of Antimicrobial Chemotherapy (JAC), gives an overview of the manuscripts related to veterinary bacteriology published in the journal in the past 40 years with a focus on 'One Health' aspects. From 1975 to 2000 the number of manuscripts related to veterinary medicine was limited, but thereafter, the number steadily increased. Most manuscripts published were related to food-producing animals, but companion animals and minor species were also covered...
October 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/27642138/detection-of-bacterial-contamination-and-dna-quantification-in-stored-blood-units-in-2-veterinary-hospital-blood-banks
#10
Valentina Stefanetti, Arianna Miglio, Katia Cappelli, Stefano Capomaccio, Elisa Sgariglia, Maria L Marenzoni, Maria T Antognoni, Mauro Coletti, Vittorio Mangili, Fabrizio Passamonti
Blood transfusions in veterinary medicine have become increasingly more common and are now an integral part of lifesaving and advanced treatment in small and large animals. Important risks associated with transfusion of blood products include the transmission of various infectious diseases. Several guidelines suggest what infectious agents to screen for in canine and feline transfusion medicine. However, while the risk of bacterial contamination of blood products during storage and administration has not been documented in veterinary medicine, it has emerged as a cause of morbidity and mortality in human transfusion medicine...
September 2016: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/27633677/effects-of-local-polynesian-plants-and-algae-on-growth-and-expression-of-two-immune-related-genes-in-orbicular-batfish-platax-orbicularis
#11
Miriam Reverter, Denis Saulnier, Rarahu David, Agnès Bardon-Albaret, Corinne Belliard, Nathalie Tapissier-Bontemps, David Lecchini, Pierre Sasal
The emerging orbicular batfish (Platax orbicularis) aquaculture is the most important fish aquaculture industry in French Polynesia. However, bacterial infections are causing severe mortality episodes. Therefore, there is an urgent need to find an effective management solution. Besides the supplying difficulty and high costs of veterinary drugs in French Polynesia, batfish aquaculture takes place close to the coral reef, where use of synthetic persistent drugs should be restricted. Medicinal plants and bioactive algae are emerging as a cheaper and more sustainable alternative to chemical drugs...
September 12, 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27589226/use-of-large-scale-veterinary-data-for-the-investigation-of-antimicrobial-prescribing-practices-in-equine-medicine
#12
C E Welsh, T D H Parkin, J F Marshall
BACKGROUND: As antimicrobial resistant bacterial strains continue to emerge and spread in human and animal populations, understanding prescription practices is key in benchmarking current performance and setting goals. Antimicrobial prescription (AP) in companion veterinary species is widespread, but is neither monitored nor restricted in the USA and Canada. The veterinary use of certain antimicrobial classes is discouraged in some countries, in the hope of preserving efficacy for serious human infections...
September 2, 2016: Equine Veterinary Journal
https://www.readbyqxmd.com/read/27580621/characterising-and-comparing-drug-dispensing-practices-at-animal-health-outlets-in-the-rift-valley-kenya-an-exploratory-analysis-part-ii
#13
L E Higham, W Ongeri, K Asena, M V Thrusfield
A mixed-method study was conducted in the Rift Valley of Kenya to characterise drug-dispensing practices amongst staff at animal health outlets and to explore perceptions of veterinary medicines amongst pastoralists and farmers. Forty structured questionnaires were administered to staff at animal health outlets, including franchise outlets of 'Sidai Africa Ltd.', and two focus group discussions were facilitated to explore the perceptions of local animal health services by a Maasai pastoralist group and a dairy farmer cooperative...
December 2016: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/27558831/influence-of-ph-and-ozone-dose-on-sulfaquinoxaline-ozonation
#14
Vanessa Ribeiro Urbano, Milena Guedes Maniero, Montserrat Pérez-Moya, José Roberto Guimarães
Sulfaquinoxaline (SQX) is an antimicrobial of the sulfonamides class. Usually employed in veterinary medicine, this contaminant of emerging concern has been found in superficial and groundwater and its consequences for the environment and human health are not completely known. In this study, SQX (C0 = 500 μg L(-1), 1 L) degradation by an ozonation process at pH 3, 7, and 11 was evaluated. Ozonation was effective in degrading SQX: efficiency exceeding 99% was obtained applying an ozone dose of 2.8 mg L(-1) at pH 3...
August 21, 2016: Journal of Environmental Management
https://www.readbyqxmd.com/read/27558513/a-one-health-overview-facilitating-advances-in-comparative-medicine-and-translational-research
#15
Cheryl Stroud, Igor Dmitriev, Elena Kashentseva, Jeffrey N Bryan, David T Curiel, Hans Rindt, Carol Reinero, Carolyn J Henry, Philip J Bergman, Nicola J Mason, Josephine S Gnanandarajah, Julie B Engiles, Falon Gray, Danielle Laughlin, Anita Gaurnier-Hausser, Anu Wallecha, Margie Huebner, Yvonne Paterson, Daniel O'Connor, Laura S Treml, James P Stannard, James L Cook, Marc Jacobs, Gerald J Wyckoff, Lee Likins, Ubadah Sabbagh, Andrew Skaff, Amado S Guloy, Harlen D Hays, Amy K LeBlanc, Joan R Coates, Martin L Katz, Leslie A Lyons, Gayle C Johnson, Gary S Johnson, Dennis P O'Brien, Dongsheng Duan, James P Calvet, Barbara Gandolfi, David A Baron, Mark L Weiss, Debra A Webster, Francis N Karanu, Edward J Robb, Robert J Harman
A1 One health advances and successes in comparative medicine and translational researchCheryl StroudA2 Dendritic cell-targeted gorilla adenoviral vector for cancer vaccination for canine melanomaIgor Dmitriev, Elena Kashentseva, Jeffrey N. Bryan, David T. CurielA3 Viroimmunotherapy for malignant melanoma in the companion dog modelJeffrey N. Bryan, David Curiel, Igor Dmitriev, Elena Kashentseva, Hans Rindt, Carol Reinero, Carolyn J. HenryA4 Of mice and men (and dogs!): development of a commercially licensed xenogeneic DNA vaccine for companion animals with malignant melanomaPhilip J...
August 2016: Clinical and Translational Medicine
https://www.readbyqxmd.com/read/27556225/technique-of-spinal-cord-compression-induced-by-inflation-of-epidural-balloon-catheter-in-rabbits-oryctologus-cuniculus-efficient-and-easy-to-use-model
#16
Antonio F B DA Fonseca, Jussara P Scheffer, Barbara P Coelho, Graciane Aiello, Arthur G Guimarães, Carlos R B Gama, Victor Vescovini, Paula G A Cabral, André L A Oliveira
The most common cause of spinal cord injury are high impact trauma, which often result in some motor impairment, sensory or autonomic a greater or lesser extent in the distal areas the level of trauma. In terms of survival and complications due to sequelae, veterinary patients have a poor prognosis unfavorable. Therefore justified the study of experimental models of spinal cord injury production that could provide more support to research potential treatments for spinal cord injuries in medicine and veterinary medicine...
September 2016: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/27446056/phenotypic-and-molecular-characterization-of-antimicrobial-resistance-in-klebsiella-spp-isolates-from-companion-animals-in-japan-clonal-dissemination-of-multidrug-resistant-extended-spectrum-%C3%AE-lactamase-producing-klebsiella-pneumoniae
#17
Kazuki Harada, Takae Shimizu, Yujiro Mukai, Ken Kuwajima, Tomomi Sato, Masaru Usui, Yutaka Tamura, Yui Kimura, Tadashi Miyamoto, Yuzo Tsuyuki, Asami Ohki, Yasushi Kataoka
The emergence of antimicrobial resistance in Klebsiella spp., including resistance to extended-spectrum cephalosporins (ESC) and fluoroquinolones, is of great concern in both human and veterinary medicine. In this study, we investigated the prevalence of antimicrobial resistance in a total of 103 Klebsiella spp. isolates, consisting of Klebsiella pneumoniae complex (KP, n = 89) and K. oxytoca (KO, n = 14) from clinical specimens of dogs and cats in Japan. Furthermore, we characterized the resistance mechanisms, including extended-spectrum β-lactamase (ESBL), plasmid-mediated AmpC β-lactamase (PABL), and plasmid-mediated quinolone resistance (PMQR); and assessed genetic relatedness of ESC-resistant Klebsiella spp...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27443209/an-update-discussion-on-the-current-assessment-of-the-safety-of-veterinary-antimicrobial-drug-residues-in-food-with-regard-to-their-impact-on-the-human-intestinal-microbiome
#18
Carl E Cerniglia, Silvia A Pineiro, Susan F Kotarski
The human gastrointestinal tract ecosystem consists of complex and diverse microbial communities that have now been collectively termed the intestinal microbiome. Recent scientific breakthroughs and research endeavours have increased our understanding of the important role the intestinal microbiome plays in human health and disease. The use of antimicrobial new animal drugs in food-producing animals may result in the presence of low levels of drug residues in edible foodstuffs. There is concern that antimicrobial new animal drugs in or on animal-derived food products at residue-level concentrations could disrupt the colonization barrier and/or modify the antimicrobial resistance profile of human intestinal bacteria...
May 2016: Drug Testing and Analysis
https://www.readbyqxmd.com/read/27443205/emerging-food-safety-issues-an-eu-perspective
#19
John D G McEvoy
Safe food is the right of every citizen of the European Union (EU). A comprehensive and dynamic framework of food and feed safety legislation has been put in place and the EU's executive arm - the European Commission - is responsible for ensuring that the EU member states apply food law consistently. Similarly, the Commission plays an important role in ensuring that imported food meets the EU's stringent food safety standards. Consumer perceptions of unsafe food tend to focus on acute outbreaks of bacterial or viral origin...
May 2016: Drug Testing and Analysis
https://www.readbyqxmd.com/read/27430150/opportunities-and-challenges-for-the-application-of-microfluidic-technologies-in-point-of-care-veterinary-diagnostics
#20
Valentina Busin, Beth Wells, Maïwenn Kersaudy-Kerhoas, Wenmaio Shu, Stewart T G Burgess
There is a growing need for low-cost, rapid and reliable diagnostic results in veterinary medicine. Point-of-care (POC) tests have tremendous advantages over existing laboratory-based tests, due to their intrinsic low-cost and rapidity. A considerable number of POC tests are presently available, mostly in dipstick or lateral flow formats, allowing cost-effective and decentralised diagnosis of a wide range of infectious diseases and public health related threats. Although, extremely useful, these tests come with some limitations...
July 15, 2016: Molecular and Cellular Probes
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