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"Fragility" and "elderly"

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https://www.readbyqxmd.com/read/29122281/good-functional-outcome-in-patients-suffering-fragility-fractures-of-the-pelvis-treated-with-percutaneous-screw-stabilisation-assessment-of-complications-and-factors-influencing-failure
#1
Henrik Eckardt, Alexander Egger, Rebecca Maria Hasler, Christoph J Zech, Werner Vach, Norbert Suhm, Mario Morgenstern, Franziska Saxer
BACKGROUND: Low energy pelvic ring fractures in the elderly have traditionally been treated conservatively, a treatment with potential long-term complications and loss of self-independence. Percutaneous screw stabilisation of the posterior pelvic ring is a new treatment modality that enables immediate mobilisation. The aim of this study was to assess the functional outcome after sacroiliac stabilisation in the elderly. METHODS: All elderly patients with a surgically stabilised low energy pelvic fracture between 2010 and 2015 were included...
November 4, 2017: Injury
https://www.readbyqxmd.com/read/29040721/ratio-of-endogenous-secretory-receptor-for-advanced-glycation-end-products-to-pentosidine-predicts-fractures-in-men
#2
Junko Tamaki, Katsuyasu Kouda, Yuki Fujita, Masayuki Iki, Akiko Yura, Masakazu Miura, Yuho Sato, Nozomi Okamoto, Norio Kurumatani
Context: Although the endogenous secretory receptor for advanced glycation end products (esRAGE) has been associated with reduced activity of pentosidine (PEN), the association between PEN, esRAGE, and fracture is poorly understood. Objectives: To evaluate the ability of serum PEN and esRAGE levels to predict fragility fractures. Methods: A cohort of 1,285 Japanese men aged ≥65 years old participated in a 2007-2008 FORMEN Study baseline survey, as part of the Fujiwara-kyo prospective cohort study...
October 12, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29038673/thiazides-and-osteoporotic-spinal-fractures-a-suspected-linkage-investigated-by-means-of-a-two-center-case-control-study
#3
Renato De Vecchis, Carmelina Ariano, Giuseppina Di Biase, Michel Noutsias
BACKGROUND: An alleged association of chronic use of thiazide diuretics with an increased risk of bone fragility fractures has been highlighted by a relatively recent prospective cohort study. However, the concept that thiazides exert a beneficial effect on osteoporosis is still a predominant view. This effect would be mediated by the decrease in renal clearance of calcium ions, a pharmacological feature recognized for a long time now to this class of drugs, as opposed to the increase in calcium urinary excretion attributed instead to loop diuretics, i...
November 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29025604/double-plating-for-bicolumnar-distal-humerus-fractures-in-the-elderly
#4
Andrea Pantalone, Daniele Vanni, Matteo Guelfi, Alberto Belluati, Vincenzo Salini
Distal humerus fractures are uncommon injuries requiring specific clinical and radiographic analysis in order to plan the optimal therapeutic strategy. In particular, bicolumnar distal humerus fractures (Type A2, A3 and C) are complex fractures. In the last years, double plating fixation became the standard treatment: this procedure helped surgeons to obtain a stable and anatomical fixation and an early mobilization, which is the main outcome for obtaining valuable functional results. In this retrospective study, we evaluated the use of open bicolumnar 90-90 plating for fixation of acute fragility fractures of the distal humerus in elderly patients, using the olecranon osteotomy as surgical approach...
October 2017: Injury
https://www.readbyqxmd.com/read/29023743/oral-health-for-an-ageing-population-the-importance-of-a-natural-dentition-in-older-adults
#5
Frauke Müller, Yoshihiro Shimazaki, Febronia Kahabuka, Martin Schimmel
Despite progress in dentistry, tooth loss in old age is still a reality, even more so in long-term-care residents. However, recent trends indicate that natural teeth are lost later in life. Functional decline and age-related pathologies have to be considered in oral health care for this vulnerable population. Retaining and restoring teeth and oral function in elders is important. Tooth loss significantly impairs masticatory performance, which cannot be fully restored by prosthodontic means. Hence an unconscious change in food intake occurs, often involving malnutrition and withdrawal from common meals...
September 2017: International Dental Journal
https://www.readbyqxmd.com/read/29021637/physical-frailty-and-fitness-of-older-driver
#6
Maria Helena Lenardt, Clovis Cechinel, Maria Angelica Binotto, Nathalia Hammerschmidt Kolb Carneiro, Tânia Maria Lourenço
AIM: to analyze the association between physical frailty and the results of fitness capacity exams for driving vehicles among elder Brazilians. METHODS: this is a cross sectional study, performed in traffic medicine clinics of the city of Curitiba (Brazil). The data was collected through the physical frailty tests, the use of a structured questionnaire, and searches on the records of the Brazilian National Register of Qualified Drivers.To analyze the information, the authors used descriptive statistics and non-parametrical tests...
June 30, 2017: Colombia Médica: CM
https://www.readbyqxmd.com/read/29019915/revolutionizing-therapeutic-drug-monitoring-with-the-use-of-interstitial-fluid-and-microneedles-technology
#7
REVIEW
Tony K L Kiang, Sahan A Ranamukhaarachchi, Mary H H Ensom
While therapeutic drug monitoring (TDM) that uses blood as the biological matrix is the traditional gold standard, this practice may be impossible, impractical, or unethical for some patient populations (e.g., elderly, pediatric, anemic) and those with fragile veins. In the context of finding an alternative biological matrix for TDM, this manuscript will provide a qualitative review on: (1) the principles of TDM; (2) alternative matrices for TDM; (3) current evidence supporting the use of interstitial fluid (ISF) for TDM in clinical models; (4) the use of microneedle technologies, which is potentially minimally invasive and pain-free, for the collection of ISF; and (5) future directions...
October 11, 2017: Pharmaceutics
https://www.readbyqxmd.com/read/28983668/yc-1-alleviates-bone-loss-in-ovariectomized-rats-by-inhibiting-bone-resorption-and-inducing-extrinsic-apoptosis-in-osteoclasts
#8
Jin-Wen Wang, Chin-Bin Yeh, Shao-Jiun Chou, Kuo-Cheng Lu, Tzu-Hui Chu, Wei-Yu Chen, Jui-Lin Chien, Mao-Hsiung Yen, Tien-Hua Chen, Jia-Fwu Shyu
Osteoporosis is a major health problem in postmenopausal women and the elderly that leads to fractures associated with substantial morbidity and mortality. Current osteoporosis therapies have significant drawbacks, and the risk of fragility fractures has not yet been eliminated. There remains an unmet need for a broader range of therapeutics. Previous studies have shown that YC-1 has important regulatory functions in the cardiovascular and nervous systems. Many of the YC-1 effector molecules in platelets, smooth muscle cells and neurons, such as cGMP and μ-calpain, also have important functions in osteoclasts...
October 5, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/28982898/the-use-of-external-beam-radiotherapy-for-muscle-invasive-bladder-cancer-in-elderly-or-medically-fragile-patients
#9
Rihito Aizawa, Masato Sakamoto, Nobuaki Orito, Masanori Kono, Masakazu Ogura, Yoshiharu Negoro, Tadashi Sagoh, Kenji Tsukahara, Kazuto Komatsu, Masato Noguchi
AIM: To evaluate the clinical results of external-beam radiotherapy (EBRT) for muscle-invasive bladder cancer (MIBC) in elderly or medically-fragile patients. PATIENTS AND METHODS: Twenty-five consecutive patients with MIBC (cT2-4N0-1M0) receiving EBRT were retrospectively analyzed. Their median age was 82 years. Radiotherapy median dose was 60 Gy administered in 30 fractions. RESULTS: Median follow-up period was 14.7 months. Median overall survival (OS) and progression-free survival (PFS) were 14...
October 2017: Anticancer Research
https://www.readbyqxmd.com/read/28976382/-approach-to-aortic-aortic-valve-diseases-in-the-elderly
#10
Hüseyin Ayhan, Engin Bozkurt
Aortic valve diseases are the most common among the valvular heart diseases. Significant increases in the frequency of degenerative aortic sclerosis and aortic stenosis (AS) are observed, particularly with aging of the population and diminished rheumatic heart disease. Aortic regurgitation (AR) is less common in the elderly and is accompanied by AS rather than pure AR. Considering the comorbid diseases, fragility and cognitive functions in elderly patients, special approach is needed during diagnosis, evaluation, treatment and follow-up...
September 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/28975362/significant-bone-loss-after-stopping-long-term-denosumab-treatment-a-post-freedom-study
#11
M B Zanchetta, J Boailchuk, F Massari, F Silveira, C Bogado, J R Zanchetta
We evaluate 38 elderly women who had received long-term denosumab treatment after stopping the drug. Taking into account the gain during treatment and the loss after stopping treatment, they lost 35.5% of the total gain in the spine, 44.6% of the total gain in the femoral neck, and 103.3% in the total hip. INTRODUCTION: Denosumab (DMAb) is a soluble inhibitor of the receptor activator of nuclear factor-kappaB ligand (RANKL) and, therefore, does not incorporate into the bone matrix. Consistently, DMAb discontinuation is associated with reversal of the effects attained with treatment...
October 3, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28956331/phosphodiesterase-4b-as-a-therapeutic-target-for-cognitive-impairment-and-obesity-related-metabolic-diseases
#12
Steven J Clapcote
People in modern, affluent societies are living longer but also becoming increasingly overweight. With increased life expectancy comes increased risk of developing age-related cognitive decline and neurodegenerative diseases, such that an increasing proportion of life may be lived with cognitive impairment as age increases. Obesity is associated with poorer cognitive function in elderly subjects, and often leads to ill-health arising from various complications such as metabolic syndrome and type-2 diabetes mellitus...
2017: Advances in Neurobiology
https://www.readbyqxmd.com/read/28912385/-primary-fracture-prevention-through-the-osteoporosis-liaison-service
#13
Shinichi Nakatoh
It is difficult to prevent primary fragility fractures because the subjects have not yet experienced a fracture. The offers of the community Osteoporosis Liaison Service are important for primary prevention of fragility fractures. The prevention, education, enlightenment, and the offer of osteoporosis examinations are included in this service. It is necessary to deliver the prevention services and osteoporosis education according to the age of the subjects. Hence, for young people, it is effective to include in school education that getting high peak bone mass is important, and for the middle-aged population, it is necessary to include education on the maintenance of bone quantity and the impact on risk factors such as smoking and excessive alcohol consumption...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28910544/human-microbiota-in-aging-and-infection-a-review
#14
Elisavet Stavropoulou, Eugenia Bezirtzoglou
In most developed countries, ageing of the population started more than a century ago and it seems to be emerged in a wide range of developing countries as well. Moreover, research into ageing has moved forward in extremely rapidly rhythms nowadays, and the scientific area is of great interest, as implications for nearly all sectors of society, including work, social, economic features, in addition to nutrition and health issues which are involved. The fragile elder population is affected and experienced more frequently infections than the younger population...
September 14, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/28906354/the-influence-of-renal-dialysis-and-hip-fracture-sites-on-the-10-year-mortality-of-elderly-hip-fracture-patients-a-nationwide-population-based-observational-study
#15
Li-Wei Hung, Yi-Ting Hwang, Guey-Shiun Huang, Cheng-Chih Liang, Jinn Lin
Hip fractures in older people requiring dialysis are associated with high mortality. Our study primarily aimed to evaluate the specific burden of dialysis on the mortality rate following hip fracture. The secondary aim was to clarify the effect of the fracture site on mortality. A retrospective cohort study was conducted using Taiwan's National Health Insurance Research Database to analyze nationwide health data regarding dialysis and non-dialysis patients ≥65 years who sustained a first fragility-related hip fracture during the period from 2001 to 2005...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28891093/tocotrienols-for-bone-health-a-translational-approach
#16
REVIEW
Chwan-Li Shen, Annika Klein, Kok-Yong Chin, Huanbiao Mo, Peihsuan Tsai, Rong-Sen Yang, Ming-Chien Chyu, Soelaiman Ima-Nirwana
Osteoporosis, a degenerative bone disease, is characterized by low bone mass and microstructural deterioration of bone tissue resulting in aggravated bone fragility and susceptibility to fractures. The trend of extended life expectancy is accompanied by a rise in the prevalence of osteoporosis and concomitant complications in the elderly population. Epidemiological evidence has shown an association between vitamin E consumption and the prevention of age-related bone loss in elderly women and men. Animal studies show that ingestion of vitamin E, especially tocotrienols, may benefit bone health in terms of maintaining higher bone mineral density and improving bone microstructure and quality...
August 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28870622/how-can-we-influence-the-incidence-of-secondary-fragility-fractures-a-review-on-current-approaches
#17
Hans-Christoph Pape, Heike A Bischoff-Ferrari
With the increasing number of elderly patients presenting with fragility fractures, their care has become a focus among trauma and orthopaedic surgeons. Protocols are ever evolving to improve the clinical pathways and treatment modalities targeting a more efficient and patient centred service. In this article, current approaches and their potential to reduce mortality and re-fracture in these patients are discussed.
September 1, 2017: Injury
https://www.readbyqxmd.com/read/28855317/novel-skeletal-effects-of-glucagon-like-peptide-1-glp-1-receptor-agonists
#18
Guillaume Mabilleau, Marie Pereira, Chantal Chenu
Type 2 diabetes mellitus (T2DM) leads to bone fragility and predisposes to increased risk of fracture, poor bone healing and other skeletal complications. In addition, some anti-diabetic therapies for T2DM can have notable detrimental skeletal effects. Thus an appropriate therapeutic strategy for T2DM should not only be effective in re-establishing good glycaemic control but also in minimising skeletal complications. There is increasing evidence that Glucagon-like peptide-1 receptor (GLP-1r) agonists, now greatly prescribed for the treatment of T2DM, have beneficial skeletal effects although the underlying mechanisms are not completely understood...
August 30, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28854917/combination-of-measures-of-handgrip-strength-and-red-cell-distribution-width-can-predict-in-hospital-complications-better-than-the-asa-grade-after-hip-fracture-surgery-in-the-elderly
#19
Hyung-Min Ji, Jun Han, Hi-Won Bae, Ye-Yeon Won
BACKGROUND: Early detection of a high-risk patient following hip fracture surgery is of paramount clinical importance. American Society of Anesthesiologists (ASA) grading is an easy and efficient index in predicting a worse outcome. The red cell distribution width (RDW) and handgrip strength, are gaining interest as a prediction tool as well. Accordingly, the objective of this study was to investigate the potential association between ASA, RDW and grip strength and detect the effects of combining RDW and grip strength for predicting early complication after hip fracture surgery in the elderly...
August 30, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28851522/dementia-and-fragility-fractures-issues-and-solutions
#20
James S H Vun, Milad Ahmadi, Michalis Panteli, Ippokratis Pountos, Peter V Giannoudis
Dementia and fragility fractures are two conditions that pose significant morbidity and mortality to the elderly population. The occurrence of the 'gerontic' boom as a result of improved healthcare meant a continued increase in the prevalence of fragility fractures and dementia. This represents a major public health problem with significant socioeconomic repercussions. It is therefore important for healthcare professionals to gain a better understanding on the relationship between these two commonly co-existing conditions...
August 26, 2017: Injury
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