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Ankylosing spondylitis treatment

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https://www.readbyqxmd.com/read/29148408/effects-and-safety-of-99tc-mdp-in-patients-with-refractory-ankylosing-spondylitis-a-2-stage-30-week-follow-up-clinical-trial
#1
Yunyun Xu, Yi Zhong, Minjing Zhao, Liudan Tu, Meida Fan, Pingping Zhang, Qiujing Wei, Shuangyan Cao, Qiuxia Li, Zetao Liao, Zhiming Lin, Yunfeng Pan, Ou Jin, Jieruo Gu
OBJECTIVES: To evaluate the clinical efficacy and safety in patients with refractory ankylosing spondylitis (AS) initiating 99Tc-MDP therapy and explore the mechanisms. METHODS: Refractory AS patients were enrolled in the clinical trial and received 99Tc-MDP treatments for 3 or 5 courses according to ASAS improvement. Efficacy and safety evaluations were conducted during the follow-up. 37 cytokines were quantified by Luminex at baseline and week 30. p-values<0...
November 14, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29148406/high-3-year-golimumab-survival-in-patients-with-rheumatoid-arthritis-ankylosing-spondylitis-and-psoriatic-arthritis-real-world-data-from-328-patients
#2
Konstantinos Thomas, Irini Flouri, Argiro Repa, Kalliopi Fragiadaki, Petros P Sfikakis, Christos Koutsianas, Evripidis Kaltsonoudis, Paraskevi V Voulgari, Alexandros A Drosos, Evangelia Petrikkou, Prodromos Sidiropoulos, Dimitrios Vassilopoulos
OBJECTIVES: Our primary objective was to study the long-term survival on drug (SOD) of patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA) and ankylosing spondylitis (AS) treated with golimumab (GLM) in real life settings. METHODS: This was a retrospective, observational study of all patients treated with GLM in 4 Academic Centres in Greece during a 4-year period (09/2010-06/2014). SOD was analysed using Kaplan-Meier survival analysis, while Cox regression analysis estimating hazard ratios (HRs) for different baseline variables associated with drug discontinuation was performed for each disease...
November 9, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29148281/treatment-patterns-of-biologics-in-us-patients-with-ankylosing-spondylitis-descriptive-analyses-from-a-claims-database
#3
Jessica A Walsh, Oluwakayode Adejoro, Benjamin Chastek, Yujin Park
AIM: Examine treatment patterns among patients with active ankylosing spondylitis (AS) treated with a TNF inhibitor (TNFi). PATIENTS & METHODS: Patients with AS who initiated a TNFi between 1 January 2013, and 31 January 2015, were identified in the Optum Research Database. Outcomes included adherence, persistence, discontinuation and therapy modifications of the index TNFi during 12-month follow-up. RESULTS: Of the 426 patients included, 40...
November 17, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/29147967/association-of-inflammatory-bowel-disease-with-arthritis-evidence-from-in-silico-gene-expression-patterns-and-network-topological-analysis
#4
Anukriti Verma, Pallavi Somvanshi, Shafiul Haque, Bhawna Rathi, Shivani Sharda
Inflammatory bowel disease (IBD) is an idiopathic prolonged ailment accountable for inflammatory conditions of the intestine. Moreover, arthritis is responsible for joints' stiffness and painful inflammation. IBD shows certain articular extra-intestinal manifestations associating IBD with arthritis. IBD associated arthritis is found to be linked with ankylosing spondylitis (AS). The present study insights for the potential and putative drug targets and biomarkers of IBD associated with arthritis using in silico approaches...
November 17, 2017: Interdisciplinary Sciences, Computational Life Sciences
https://www.readbyqxmd.com/read/29142035/the-sex-influence-on-response-to-tumor-necrosis-factor-%C3%AE-inhibitors-and-remission-in-axial-spondyloarthritis
#5
Ennio Lubrano, Fabio Massimo Perrotta, Maria Manara, Salvatore D'Angelo, Olga Addimanda, Roberta Ramonda, Leonardo Punzi, Ignazio Olivieri, Carlo Salvarani, Antonio Marchesoni
OBJECTIVE: The aim of this study was to evaluate the influence of sex on response to treatment and disease remission in patients with axial spondyloarthritis (axSpA). METHODS: In this retrospective multicenter study, patients with axSpA, according to the Assessment of Spondyloarthritis international Society (ASAS) criteria for axSpA, and treated with adalimumab, etanercept, golimumab, or infliximab, were studied. We compared clinical characteristics, patient-reported outcomes, disease activity, function, and response to treatment in male and female patients with this disease...
November 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/29142031/activity-limitations-in-patients-with-axial-spondyloarthritis-a-role-for-fear-of-movement-and-re-injury-beliefs
#6
Thijs W Swinnen, Johan W S Vlaeyen, Wim Dankaerts, Rene Westhovens, Kurt de Vlam
OBJECTIVE: To determine whether fear of movement and (re)injury [FOM/(R)I] beliefs, measured with the Tampa Scale for Kinesiophobia 11-item version (TSK-11), influence activity limitations and mediate the relationship between pain severity and activity limitations in axial spondyloarthritis (axSpA). METHODS: In 173 patients with axSpA, these data were collected: sex, body mass index, disease duration, medication, activity limitations (BASFI; Bath Ankylosing Spondylitis Functional Index), disease activity [Bath Ankylosing Spondylitis Disease Activity Index (BASDAI); BASDAIinf, items 5 and 6; BASDAIpain, items 2 and 3; C-reactive protein and physician's global assessment], spinal mobility (BASMI; Bath Ankylosing Spondylitis Metrology Index), and FOM/(R)I (TSK-11)...
November 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/29136797/unparalleled-sample-treatment-throughput-for-proteomics-workflows-relying-on-ultrasonic-energy
#7
Susana Jorge, J E Araújo, F M Pimentel-Santos, Jaime C Branco, Hugo M Santos, Carlos Lodeiro, J L Capelo
We report on the new microplate horn ultrasonic device as a powerful tool to speed proteomics workflows with unparalleled throughput. 96 complex proteomes were digested at the same time in 4min. Variables such as ultrasonication time, ultrasonication amplitude, and protein to enzyme ratio were optimized. The "classic" method relying on overnight protein digestion (12h) and the sonoreactor-based method were also employed for comparative purposes. We found the protein digestion efficiency homogeneously distributed in the entire microplate horn surface using the following conditions: 4min sonication time and 25% amplitude...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29128828/quantitative-assessment-of-betamethasone-dual-acting-formulation-in-urine-of-patients-with-rheumatoid-arthritis-and-ankylosing-spondylitis-after-single-dose-intramuscular-administration-and-its-application-to-long-term-pharmacokinetic-study
#8
Arthur T Kopylov, Alexander A Novikov, Anna L Kaysheva, Igor T Vykhodets, Dmitry E Karateev, Victor G Zgoda, Andrey V Lisitsa
Quantitative evaluation and assessment of pharmacokinetic parameters of Diprospan(®) (suspension for injection 7mg/mL (2mg+5mg/mL) of betamethasone) were performed in urine samples taken from patients with rheumatoid arthritis or ankylosing spondylitis for 28days after systemic intramuscular administration in routine clinical practice in an open-comparative prospective cohort study. The maximum betamethasone concentration was reached at day 4 of the follow-up; in some cases, β-phase of elimination of the drug was appeared at day 14 or at day 21 of the follow-up...
November 6, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29127910/evaluation-of-the-efficacy-and-safety-of-%C3%AE-d-mannuronic-acid-in-patients-with-ankylosing-spondylitis-a-12-week-randomized-placebo-controlled-phase-i-ii-clinical-trial
#9
Mohammad Javad Fattahi, Ahmad Reza Jamshidi, Mahdi Mahmoudi, Mahdi Vojdanian, Mir Saeed Yekaninejad, Fahimeh Jafarnezhad-Ansariha, Hossein Ahmadi, Bernd H A Rehm, Hidenori Matsuo, Salvatore Cuzzocrea, Mostafa Hosseini, Seyed Naser Hashemi, Zahra Aghazadeh, Abbas Mirshafiey
OBJECTIVE: To evaluate the efficacy, safety and tolerability of β-d-mannuronic acid (M2000) in the treatment of ankylosing spondylitis (AS). METHODS: The study was a 12-week randomized, double-blind, placebo-controlled, phase I/II clinical trial with 3 treatment arms: placebo, β-d-mannuronic acid and naproxen. Patients who had AS according to the modified New York criteria, with active disease at baseline were eligible for study. Primary outcome measure was the Assessment of SpondyloArthritis international Society (ASAS) 20 response rate at week 12...
November 8, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29124994/a-review-on-biosimilar-infliximab-ct-p13-in-the-treatment-of-inflammatory-bowel-disease
#10
Klaudia Farkas, Tamás Molnár
The introduction of biological agents has led to significant changes in the treatment of inflammatory bowel disease (IBD). The relatively high price of infliximab (IFX) and the expiration of the patents led to the introduction of biosimilar agents. CT-P13 was the first IFX biosimilar approved in the same indications as the reference product; however, the approval was based on randomized clinical trials conducted in patients with rheumatoid arthritis and ankylosing spondylitis. In the past 2-3 years, new findings from prospective observational studies supported the short-, medium- and long-term clinical efficacy and safety of CT-P13 in patients with IBD...
November 10, 2017: Immunotherapy
https://www.readbyqxmd.com/read/29101454/-surgical-management-of-ankylosing-spondylitis-bechterew-s-disease
#11
REVIEW
H Allouch, M Shousha, H Böhm
Ankylosing spondylitis is an inflammatory rheumatic disease that is often associated with back pain and restricted spinal movement. In the later stages of the disease, complete ossification of the entire spine and severe deformity can occur, often resulting in a marked reduction in quality of life and an increased risk of loss of independence due to diminished visual field. Patients with ankylosing spondylitis are at greater risk of spinal fractures. These are generally complex fractures associated with high morbidity and mortality; in addition, neurological deficits are not unusual...
November 3, 2017: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/29095296/the-treatment-strategies-for-spine-fractures-in-patients-with-ankylosing-spondylitis-a-case-report
#12
RuSen Zhu, WenYe Song, Wei Hu, ZeHua Jiang, JianJun Yuan, ZiJian Cui, Jun Wan, Yan Liu, ShiQing Feng, XueLi Zhang
PURPOSE: The aim of the study was to explore surgical strategies for effectively treating spine fractures in patients with ankylosing spondylitis (AS) and investigate the postoperative outcomes. METHODS: We retrospectively analyzed 9 patients with AS that was complicated by spine fractures, who underwent surgery at our spine and spinal cord clinic between 2005 and 2012. The surgical methods included posterior instrumentation and bone grafting, with or without decompression...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29093622/adalimumab-efficacy-in-enteropathic-spondyloarthritis-a-12-mo-observational-multidisciplinary-study
#13
Michele Maria Luchetti, Devis Benfaremo, Francesco Ciccia, Laura Bolognini, Monia Ciferri, Alessia Farinelli, Matteo Rossini, Piergiorgio Mosca, Giovanni Triolo, Armando Gabrielli
AIM: To report adalimumab (Ada) efficacy on articular-gastrointestinal disease and health-related quality of life (HRQoL) in patients with enteropathic spondyloarthritis (ES). METHODS: A cohort of 52 patients with ES was evaluated in the departments of gastroenterology and internal medicine. At baseline, all patients underwent assessment by an integrated gastro-rheumatologic evaluation of articular and gastrointestinal activity, as well patient reported outcomes (PROs) of the HRQoL questionnaires...
October 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29075521/imaging-of-juvenile-spondyloarthritis-part-i-classifications-and-radiographs
#14
REVIEW
Iwona Sudoł-Szopińska, Piotr Gietka, Michał Znajdek, Genowefa Matuszewska, Magdalena Bogucevska, Ljubinka Damjanovska-Krstikj, Slavcho Ivanoski
Juvenile spondyloarthropathies are manifested mainly by symptoms of peripheral arthritis and enthesitis. By contrast with adults, children rarely present with sacroiliitis and spondylitis. Imaging and laboratory tests allow early diagnosis and treatment. Conventional radiographs visualize late inflammatory lesions and post-inflammatory complications. Early diagnosis is possible with the use of ultrasonography and magnetic resonance imaging. The first part of the article presents classifications of juvenile spondyloarthropathies and discusses their radiographic presentation...
September 2017: Journal of Ultrasonography
https://www.readbyqxmd.com/read/29075106/treatment-adherence-and-disease-burden-of-individuals-with-rheumatic-diseases-admitted-as-outpatients-to-a-large-rheumatology-center-in-shanghai-china
#15
Le Zhang, Guo Hong Lu, Shuang Ye, Bin Wu, Yi Shen, Ting Li
PURPOSE: The purpose of this study was to determine treatment adherence and disease burden, analyze detailed medication problems experienced by patients, and identify factors associated with adherence in patients with rheumatic diseases in China. PATIENTS AND METHODS: Patients with confirmed diagnoses of ankylosing spondylitis (AS), rheumatoid arthritis (RA), and systemic lupus erythematosus (SLE) were recruited, regardless of demographics, disease severity, and treatment characteristics...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/29067557/prevalence-of-co-existing-autoimmune-disease-in-rheumatoid-arthritis-a-cross-sectional-study
#16
Teresa A Simon, Hugh Kawabata, Nitesh Ray, Anagha Baheti, Samy Suissa, John M Esdaile
INTRODUCTION: Many autoimmune diseases, including rheumatoid arthritis (RA), share common mechanisms; however, population-based studies of the magnitude of multiple autoimmune diseases in patients with RA have not been performed. METHODS: We conducted a cross-sectional study using a US administrative healthcare thcare claims database to screen for prevalence of multiple autoimmune diseases in patients with RA and osteoarthritis (OA). Each patient diagnosed with RA between January 1, 2006 and September 30, 2014 was age- and sex-matched with five patients with OA...
October 24, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/29067128/i-bet151-inhibits-expression-of-rankl-opg-mmp3-and-mmp9-in-ankylosing-spondylitis-in-vivo-and-in-vitro
#17
Jianping Fan, Jian Zhao, Jie Shao, Xianzhao Wei, Xiaodong Zhu, Ming Li
Ankylosing spondylitis (AS) is characterized by osteoclastogenesis and inflammatory bone resorption. The present study aimed to investigate the effect of bromodomain and extra-terminal domain (BET) protein inhibitor I-BET151 on AS process. A total of 38 AS Chinese patients were recruited and a further 38 sex- and age-matched healthy participants were selected as control. The Bath AS Function Index and Bath AS Disease Activity Index were assessed in AS patients and levels of erythrocyte sedimentation rate and C-reactive protein were measured in AS and healthy groups...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29050182/-research-progress-on-andersson-lesion-in-ankylosing-spondylitis
#18
H F Wang, C Bi, Z Q Chen
Andersson lesion is a destructive vertebral or disco-vertebral lesion that occurs in the late stage of the ankylosing spondylitis. According to the etiology, these lesions are usually classified into localized lesions and extensive lesions. The history of ankylosing spondylitis and characteristic imaging is the key to the diagnosis of Andersson lesion. Conservative treatment may be effective for localized lesions. However, surgical intervention is often required for the failure of conservative treatment and extensive lesions...
October 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29050160/-value-of-mdixon-quant-sequence-diffusion-weighted-imaging-in-quantitatively-diagnosing-the-sacroiliitis-stages
#19
Y Y An, H X Li, Y Zhan, X W Lei
Objective: To evaluate the value of mDIXON-Quant sequence, diffusion-weighted imaging (DWI) in quantitative diagnosing of the sacroiliitis stages in patients with ankylosing spondylitis (AS). Methods: Based on the Bath Ankylosing Spondylitis Activity Index (BASDAI) and laboratory parameters, a total of 51 patients were diagnosed with AS. They were divided into two groups as early active group (n=20) and chronic active group (n=31), and at the same time, 25 healthy people from Tianjin were included as control group...
October 10, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29045965/-cause-analysis-of-spinal-surgery-in-ankylosing-spondylitis
#20
R Liu, L Sun, C H Li, J Y Zhai, X Y Liu
OBJECTIVE: To investigate the common cause of spinal surgery in ankylosing spondylitis (AS) and to develop reasonable and effective treatment programs for rhematologists. METHODS: In this study, 79 AS patients (72 males, 7 females) hospitalized in the Department of Orthopedic and received spinal surgery in Peking University Third Hospital from January 2007 to July 2013 were investigated retrospectively. The causes of the spinal surgery were analyzed. RESULTS: The majority of the surgery were of cervical vertebra surgery for 59 cases (74...
October 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
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