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JOURNAL ARTICLE
Ri-Na Sa, Ai-Qiong Wang, You-Han Gao, Xiao-An Li, Hugejiletu
OBJECTIVES: To study the efficacy of bronchoalveolar lavage (BAL) combined with prone positioning in children with Mycoplasma pneumoniae pneumonia (MPP) and atelectasis and its effect on pulmonary function. METHODS: A prospective study was conducted on 94 children with MPP and atelectasis who were hospitalized in Ordos Central Hospital of Inner Mongolia from November 2020 to May 2023. The children were randomly divided into a treatment group and a control group, with 47 children in each group...
January 15, 2024: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
#2
JOURNAL ARTICLE
Rikke Bjersand Sunde, Jonathan Thorsen, Min Kim, Ann-Marie Malby Schoos, Jakob Stokholm, Klaus Bønnelykke, Hans Bisgaard, Bo Chawes
BACKGROUND: We previously showed an association between neonatal bacterial airway colonisation and increased risk of persistent wheeze/asthma until age 5 years. Here, we study the association with persistent wheeze/asthma and allergy-related traits until age 18 years. METHODS: We investigated the association between airway colonisation with Streptococcus pneumoniae , Moraxella catarrhalis and/or Haemophilus influenzae in 1-month-old neonates from the COPSAC2000 mother-child cohort and the development of persistent wheeze/asthma and allergy-related traits longitudinally until age 18 years using generalised estimating equations...
January 2024: European Respiratory Journal
#3
JOURNAL ARTICLE
Marina Sourouni, Ariane Germeyer, Manuel Feißt, Alexandra Balzer, Helen Köster, Annemarie Minte, Dörthe Brüggmann, Celine Kohll, Kristin Reinhardt, Michaela Möginger, Anja Leonhardt, Constanze Banz-Jansen, Michael Bohlmann, Christiane Fröhlich, Clara Backes, Dietrich Hager, Lisa Kaup, Elsa Hollatz-Galuschki, Charlotte Engelbrecht, Filiz Markfeld-Erol, Carsten Hagenbeck, Hening Schäffler, Jennifer Winkler, Johannes Stubert, Katharina Rathberger, Laura Lüber, Linda Hertlein, Antonia Machill, Manuela Richter, Martin Berghäuser, Michael Weigel, Mirjam Morgen, Nora Horn, Peter Jakubowski, Bastian Riebe, Babett Ramsauer, Robert Sczesny, Ute Margaretha Schäfer-Graf, Susanne Schrey, Sven Kehl, Julia Lastinger, Sven Seeger, Olaf Parchmann, Antonella Iannaccone, Jens Rohne, Luise Gattung, Christine A Morfeld, Michael Abou-Dakn, Markus Schmidt, Michaela Glöckner, Anja Jebens, Kathleen Marie Sondern, Ulrich Pecks, Ralf Schmitz, Mareike Möllers
INTRODUCTION: Studies have shown that pregnant women with COVID-19 have a higher risk of intensive care unit admission and invasive mechanical ventilation support than non-pregnant women. Pregnancy-associated physiological changes in respiratory function may contribute to the elevated risk. Alteration in lung volumes and capacities are attributed to the mechanical impediment caused by the growing fetus. Multiple pregnancies may therefore compromise functional lung capacity earlier than singleton pregnancies and contribute to severe respiratory symptoms of COVID-19...
December 2023: Geburtshilfe und Frauenheilkunde
#4
JOURNAL ARTICLE
Yongmei Liu, Danying Chen, Yuanyuan Wang, Xinglin Li, Yaruo Qiu, Mei Zheng, Yanjun Song, Guoli Li, Chuan Song, Tingting Liu, Yuanyuan Zhang, Ju-Tao Guo, Hanxin Lin, Xuesen Zhao
Canine coronavirus-human pneumonia-2018 (CCoV-HuPn-2018) was recently isolated from a child with pneumonia. This novel human pathogen resulted from cross-species transmission of a canine coronavirus. It has been known that CCoV-HuPn-2018 uses aminopeptidase N (APN) from canines, felines, and porcines, but not humans, as functional receptors for cell entry. The molecular mechanism of cell entry in CCoV-HuPn-2018 remains poorly understood. In this study, we demonstrated that among the nine APN orthologs tested, the APN of the Mexican free-tailed bat could also efficiently support CCoV-HuPn-2018 spike (S) protein-mediated entry, raising the possibility that bats may also be an alternative host epidemiologically important for the transmission of this virus...
September 7, 2023: Journal of Virology
#5
JOURNAL ARTICLE
Jiyi Huang, Zhibin Guo, Junkai Duan, Yong Zou, Kuai Chen, Hui Huang, Sheng Zhang, Yunguo Zhou
Coronavirus disease 2019 (COVID-19) has become a significant global public health problem. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), which causes the disease, utilizes angiotensin-converting enzyme II (ACE2) as a major functional receptor to enter host cells. No study has systematically assessed ACE2 expression in multiple tissues in children. This study investigated ACE2 expression and ACE2 protein's histological distribution in various organs in paediatric patients (the small intestine, thymus, heart and lungs)...
September 7, 2023: Journal of Tropical Pediatrics
#6
Unique presentation of late-onset Pneumocystis pneumonia in a pediatric kidney transplant recipient.
Manpreet Grewal, Ruma Srivastava, Jocelyn Y Ang, Hossein Salimnia, Amrish Jain
BACKGROUND: Restrictive lung disease leading to abnormal lung function in kidney transplant recipients is commonly associated with noninfectious complications or medications used for post-transplant immunosuppression. Herein, we report an interesting case of pediatric kidney transplant recipient with weight loss and abnormal spirometry who was diagnosed to have late-onset Pneumocystis pneumonia. CASE REPORT: A 17-year-old male patient with a history of allergic rhinitis, mild persistent asthma, and deceased donor kidney transplant, performed 18 months prior, presented for routine evaluation of his asthma to the pulmonology clinic...
July 13, 2023: Pediatric Transplantation
#7
JOURNAL ARTICLE
Päria Miraftabi, Turkka Kirjavainen, Janne S Suominen, Jouko Lohi, Laura Martelius
PURPOSE: Childhood interstitial lung disease (chILD) is an umbrella concept covering a wide range of rare lung diseases, many of which are unique to childhood. The diagnosis is based on clinical presentation, multidetector computed tomography (MDCT), genetic testing, lung-function testing, and lung biopsy. Because knowledge of the usefulness of MDCT pattern recognition in ChILD is at present limited, we examined the occurrence of MDCT patterns in children with histologically confirmed interstitial lung disease...
May 20, 2023: European Journal of Radiology
#8
REVIEW
Andrew J Collaro, Margaret S McElrea, Julie M Marchant, Mark D Chatfield, Peter Sondergeld, Jennifer L Perret, Don Vicendese, Wanaporn Anuntaseree, Shyamali C Dharmage, Anne B Chang
Early childhood respiratory infections, including pneumonia, are an important global public health issue, with more than 40 million annual cases resulting in approximately 650 000 deaths. A growing number of published studies have examined the effects of early childhood lower respiratory tract infections (LRTIs) or pneumonia on lung function, particularly as part of large early-life exposure studies. To our knowledge, there is no published systematic review of these data. We searched PubMed, Embase, and Web of Science for studies published between database inception and May 12, 2022...
June 2023: Lancet Child & Adolescent Health
#9
JOURNAL ARTICLE
Yang Li, Elias Seidl, Katrin Knoflach, Florian Gothe, Maria Elisabeth Forstner, Katarzyna Michel, Ingo Pawlita, Florian Gesenhues, Franziska Sattler, Xiaohua Yang, Carolin Kroener, Simone Reu-Hofer, Julia Ley-Zaporozhan, Birgit Kammer, Ingrid Krüger-Stollfuß, Julien Dinkel, Julia Carlens, Martin Wetzke, Antonio Moreno-Galdó, Alba Torrent-Vernetta, Joanna Lange, Katarzyna Krenke, Nisreen Rumman, Sarah Mayell, Tugba Sismanlar, Ayse Aslan, Nicolas Regamey, Marijke Proesmans, Florian Stehling, Lutz Naehrlich, Kilinc Ayse, Sebastian Becker, Cordula Koerner-Rettberg, Erika Plattner, Effrosyni D Manali, Spyridon A Papiris, Ilaria Campo, Matthias Kappler, Nicolaus Schwerk, Matthias Griese
BACKGROUND: The majority of patients with childhood interstitial lung disease (chILD) caused by pathogenic variants in ATP binding cassette subfamily A member 3 (ABCA3) develop severe respiratory insufficiency within their first year of life and succumb to disease if not lung transplanted. This register-based cohort study reviews patients with ABCA3 lung disease who survived beyond the age of 1 year. METHOD: Over a 21-year period, patients diagnosed as chILD due to ABCA3 deficiency were identified from the Kids Lung Register database...
June 2023: Thorax
#10
JOURNAL ARTICLE
Zhiying Tian, Asif Iqbal Khan, Ata Ur Rehman, Ting Deng, Chao Ma, Liang Wang
Paediatric pneumonia is a respiratory infection that affects infants and young children under the age of 3. This disease is the leading cause of infant and child mortality in developing countries because of the weak immune system of young children. The difficulty and length of time required to identify the pathogen and causative agent are the main reasons for this high mortality rate. In addition, the identification of certain causative agents is particularly important for the treatment of paediatric pneumonia...
January 9, 2023: Gut Pathogens
#11
JOURNAL ARTICLE
Ke Fang, Jun Wang, Ruixiang Sun, Peng Zhang, Qiancheng Xu, Yang Li, Haijiao Jiang, Xiaogan Jiang
OBJECTIVE: To summarize the treatment process of rapid decrease in blood flow due to centrifugal pump dysfunction during extracorporeal membrane oxygenation (ECMO) and its related thinking. METHODS: On September 25, 2021, the ECMO treatment of a 14-year-old boy with severe mycoplasma pneumonia, severe viral pneumonia and acute respiratory distress syndrome (ARDS) admitted to the department of critical care medicine of the First Affiliated Hospital of Wannan Medical College was analyzed...
October 2022: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
#12
JOURNAL ARTICLE
Tahira West, Nikita Williamson, Javeed Akhter
The loss of function (LOF) due to mutations in the Filamin A (FLNA) gene may result in abnormality of the FLNA protein. Of the many clinical syndromes, this condition may produce chronic lung disease, which usually presents and is diagnosed in the infant/toddler age group. Its clinical pattern may mimic broncho-pulmonary dysplasia. It is part of the entities included in childhood interstitial lung disease group of disorders. We are herein reporting a patient that was diagnosed with FLNA-associated lung disease at 11 years of age...
September 29, 2022: Pediatric Pulmonology
#13
Pravin R R, Suresh Chandran, Yi Hua Tan, Biju Thomas, Jan Hau Lee, Anuradha P Menon, Kim Kiat Ong, Arun Kumar Pugalenthi
Extracorporeal membrane oxygenation (ECMO) is a life-saving rescue therapy used in acute respiratory failure refractory to invasive mechanical ventilation. Recent studies on positive outcomes of extended ECMO therapy are promising. We describe a case of a 2-year 8-month-old female child with necrotizing pneumonia secondary to Streptococcus pneumoniae , Influenza A , and Mycoplasma pneumoniae , who survived with intact neurological function and no long-term adverse outcomes after a prolonged ECMO run of 86 days...
July 2022: Clinical Case Reports
#14
JOURNAL ARTICLE
Jia-Ying Lei, Han Chen, Dun-Hua Zhou, Lu-Hong Xu, Jian-Pei Fang, You-Gang Mai
BACKGROUND: Immune reconstitution inflammatory syndrome (IRIS) refers to the phenomenon of intense immune responses against pathogens in patients with AIDS undergoing antiretroviral therapy to reconstitute immune function, resulting in functional impairment of multiple organs. Non-AIDS immunosuppressed hosts may also develop similar manifestations to IRIS during immune recovery. CASE PRESENTATION: An 8-year-old girl presented with acute lymphoblastic leukaemia was admitted for scheduled chemotherapy treatment...
July 12, 2022: BMC Pediatrics
#15
JOURNAL ARTICLE
Winfried Baden, Michael Hofbeck, Steven W Warmann, Juergen F Schaefer, Ludger Sieverding
BACKGROUND: Bronchopleural fistula (BPF) is a severe complication following pneumonia or pulmonary surgery, resulting in persistent air leakage (PAL) and pneumothorax. Surgical options include resection, coverage of the fistula by video-assisted thoracoscopic surgery (VATS), or pleurodesis. Interventional bronchoscopy is preferred in complex cases and involves the use of sclerosants, sealants and occlusive valve devices. CASE PRESENTATION: A 2.5-year-old girl was admitted to our hospital with persistent fever, cough and dyspnoea...
May 5, 2022: BMC Pediatrics
#16
JOURNAL ARTICLE
Franca Rusconi, Enrico Lombardi, Elena Spada, Sonia Brescianini, Martina Culasso, Francesca Di Toro, Antonella Frassanito, Lorenzo Richiardi, Luca Ronfani, Ileana Stella, Luigi Gagliardi
OBJECTIVE: To evaluate the relationship between lower respiratory tract infections (LRTI), in the first 2 years of life and lung function at school age in the Piccolipiù birth cohort (Italy). METHODS: Data on LRTI (doctor diagnosis of bronchitis, bronchiolitis, pneumonia) and wheezing (≥3 episodes or a diagnosis of asthmatic bronchitis) in the first 2 years of life were obtained from parental questionnaires. Lung function was assessed at 7 years by spirometry and forced volume vital capacity (FVC), forced expiratory volume in 1 s (FEV1), FEV1/FVC, forced expiratory flow between 25% and 75%, and at 75% of FVC (FEF25-75 and FEF75 ) were reported as Z-scores...
April 2022: Pediatric Pulmonology
#17
JOURNAL ARTICLE
Tiantian Lu, Bin Liang, Yanping Jia, Jiangyun Cai, Danhong Wang, Min Liu, Bo He, Qing Wang
BACKGROUND: We aimed to investigate the relationship between the level of serum 25 hydroxyvitamin D [25-(OH)D] at birth and the complications of bronchopulmonary dysplasia (BPD), as well as the long-term lung function of preterm infants. METHODS: A total of 286 premature infants who were admitted to the neonatal ward of Haikou Maternal and Child Health Hospital from January 2018 to December 2020 and met the inclusion criteria were selected as the research objects...
November 2021: Translational Pediatrics
#18
JOURNAL ARTICLE
Engi F Attia, Hellen Moraa, Elizabeth Maleche-Obimbo, Dalton Wamalwa, Laurén A Gómez, Sarah Rylance, Rumbidzayi Vundla, Rashida A Ferrand, Catherine J Karr, Grace C John-Stewart, Sarah F Benki-Nugent
BACKGROUND: Impaired lung function is common among older children with perinatally acquired HIV (PHIV) who initiated antiretroviral therapy (ART) late in childhood. We determined the prevalence of abnormal spirometry and cofactors for impaired lung function among school-age children with PHIV who initiated ART when aged 12 months or younger. SETTING: Children who received early ART in the Optimizing Pediatric HIV-1 Therapy study in Kenya and underwent spirometry at school age...
January 1, 2022: Journal of Acquired Immune Deficiency Syndromes: JAIDS
#19
REVIEW
Aaron St-Laurent, Zofia Zysman-Colman, David Zielinski
Children with neuromuscular, chronic neurologic, and chest wall diseases are at increased risk of postoperative respiratory complications including atelectasis, pneumonia, and respiratory failure with the possible need for reintubation or even tracheostomy. These complications negatively impact patient outcomes, including increased healthcare resource utilization and increased surgical mortality. In these children, the existing respiratory reserve is often inadequate to withstand the stresses brought on during anesthesia and surgery...
February 2022: Paediatric Anaesthesia
#20
Linxia Deng, Yaxian Chen, Xiufen Hu, Jianhua Zhou, Yu Zhang
Interstitial lung disease (ILD) as an initial manifestation of lupus is rare, especially in young children. Here, we report a case of a 3-year-old boy who presented with fever, shortness of breath, and facial erythema. Clinical examination suggested a diagnosis of active systemic lupus erythematosus (SLE) with butterfly rash, anemia, positive antinuclear antibody, positive anti-double-stranded DNA, and hypocomplementemia. On retrospective review of the patient's records, multiple chest computed tomography (CT) images showed non-specific interstitial pneumonia + organizing pneumonia pattern, with no further autoimmune work-up during the visit to a respiratory department...
2021: Frontiers in Immunology
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