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Pneumonia & lung function children

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https://www.readbyqxmd.com/read/29710526/xianyu-decoction-attenuates-the-inflammatory-response-of-human-lung-bronchial-epithelial-cell
#1
Chenyi Yu, Qiangwei Xiang, Hailin Zhang
BACKGROUND: Xianyu decoction (XD), a Chinese experience recipe, shows inhibitory effects on lung cancer. However, the potential functions of XD on pneumonia were unknown. This study aimed to investigate the effect of XD on inflammatory response of childhood pneumonia. METHODS: Human lung bronchial epithelial cell line BEAS-2B was cultured in different doses of LPS with or without XD treatment. The expression of miR-15a and IKBKB were altered by transfection assay...
April 3, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29658403/endobronchial-stenting-on-vv-ecmo-in-a-6-month-old-girl-with-right-lung-agenesis-and-severe-stenosis-of-the-left-main-bronchus
#2
Vaclav Vobruba, Jiri Votruba, Jan Bělohlávek, Tomas Grus, Pavel Leden, Tomas Zaoral, Jan Hřídel
INTRODUCTION: Lung agenesis is a rare disorder with a variable, but potentially very bad clinical course. It necessitates complex clinical management, especially in life-threatening situations. CASE REPORT: We describe a case of a 6-month-old girl with right lung agenesis who required venovenous extracorporeal membrane oxygenation (VV-ECMO) due to pneumonia complicated by exacerbated previously diagnosed left main bronchus stenosis. The stenosis was resolved by endobronchial intervention and X-ray-guided stent insertion, which enabled weaning from ECMO and was aimed at preventing such a life-threatening respiratory failure in the future...
April 1, 2018: Perfusion
https://www.readbyqxmd.com/read/29642833/-management-and-treatment-difficulties-of-multi-drug-resistant-pulmonary-tuberculosis-in-a-pediatric-case
#3
Selda Hançerli Törün, Emine Manolya Acar, Ayper Somer, Gonca Erköse, Dilek Şatana, Zuhal Bayramoğlu, Emine Çalışkan, Zeki Kılıçaslan
Tuberculosis continues to be a major health problem worldwide. Multidrug resistant tuberculosis (MDR-TB) infection that occurs in childhood is caused by adult MDR-TB agents which are in circulation and resistant to primary drugs. In this case report a 17-month-old child with MDR-TB who was cured after a 24-month therapy regimen was presented. Physical examination of a 17-month-old girl admitted to the hospital with the cause of recurrent pneumonia revealed a rubbery lymphadenopathy less than 2 cm in the right upper cervical region...
January 2018: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/29605210/a-review-of-the-etiology-and-clinical-presentation-of-non-cystic-fibrosis-bronchiectasis-a-tertiary-care-experience
#4
Ozlem Satırer, Ayse Mete Yesil, Nagehan Emiralioglu, Gökcen Dilsa Tugcu, Ebru Yalcın, Deniz Dogru, Nural Kiper, Ugur Ozcelik
INTRODUCTION: Non-cystic fibrosis(CF) bronchiectasis has been recognized in children for the past 200 years. Early childhood pneumonia and underlying conditions such as immunodeficiency, primary ciliary dyskinesia(PCD), and congenital lung pathology should be considered in the etiology. The aim of our study was to describe the clinical characteristics, laboratory, and radiological findings of a large population of patients with non-CF bronchiectasis at a tertiary center. METHODS: We analyzed the clinical findings of 187 patients diagnosed with non-CF bronchiectasis over a period of 10 years (January 2005-December 2015) at the Hacettepe University Faculty of Medicine Department of Pediatric Pulmonology...
April 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29543980/macrolide-antibiotics-for-bronchiectasis
#5
REVIEW
Carol Kelly, James D Chalmers, Iain Crossingham, Nicola Relph, Lambert M Felix, David J Evans, Stephen J Milan, Sally Spencer
BACKGROUND: Bronchiectasis is a chronic respiratory disease characterised by abnormal and irreversible dilatation and distortion of the smaller airways. Bacterial colonisation of the damaged airways leads to chronic cough and sputum production, often with breathlessness and further structural damage to the airways. Long-term macrolide antibiotic therapy may suppress bacterial infection and reduce inflammation, leading to fewer exacerbations, fewer symptoms, improved lung function, and improved quality of life...
March 15, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29454633/long-term-sequelae-after-lung-abscess-in-children-two-tertiary-centers-experience
#6
I Wojsyk-Banaszak, K Krenke, K Jończyk-Potoczna, K Ksepko, A Wielebska, M Mikoś, A Bręborowicz
AIM: The aim of the study was to describe the epidemiology and clinical characteristic of children hospitalized with pneumonia complicated by lung abscess, as well as to evaluate the long-term sequelae of the disease. METHODS: A retrospective review of medical records of all patients treated for pulmonary abscess in two tertiary centers was undertaken. Pulmonary function tests and lung ultrasound were performed at a follow-up. RESULTS: During the study period, 5151 children with pneumonia were admitted, and 49 (0...
May 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29449834/peptidoglycan-recognition-protein-3-does-not-alter-the-outcome-of-pneumococcal-pneumonia-in-mice
#7
Anshu Shrivastav, Alexander N Dabrowski, Claudia Conrad, Nelli Baal, Holger Hackstein, Stephanie Plog, Kristina Dietert, Achim D Gruber, Philippe D N'Guessan, Sahar Aly, Norbert Suttorp, Janine Zahlten
Pneumococci frequently cause community-acquired pneumonia, a disease with high mortality rates, particularly in young children and in the elderly. Endogenous antimicrobial peptides and proteins such as PGLYRP3 may contribute to the progression and outcome of this disease. Since increasing antibiotic resistant strains occur all over the world, these endogenous antimicrobial molecules are interesting new targets for future therapies. In this study, the expression pattern of PGLYRP3 was analyzed in alveolar epithelial cells, alveolar macrophages and neutrophils...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29441886/effects-and-mechanisms-of-ambroxol-inhalation-mucosolvan-%C3%A2-in-the-treatment-of-neonatal-pneumonia
#8
Zuqin Yang, Xiuman Xiao, Yumei Huang, Xiaoxiao He, Qinqin Lu, Shangqin Chen, Zhenlang Lin
Neonatal pneumonia is the leading cause of mortality in children aged <5 years. Ambroxol (Mucosolvan®) is a mucolytic and secretolytic drug and belongs to the group of expectorants with anti-oxidative and anti-inflammatory effects. The purpose of the present study was to observe the effects and mechanisms of Mucosolvan ® inhalation on neonatal pneumonia. Between January 2014 and October 2015, a total of 80 newborns with pneumonia were randomly divided into control and observation groups. While the patients in the control group were treated with conventional treatment only, those patients in the observation group were treated with Mucosolvan® in addition to the conventional treatment...
October 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29404795/prolonged-extracorporeal-membrane-oxygenation-for-pediatric-necrotizing-pneumonia-due-to-streptococcus-pneumonia-and-influenza-h1n1-co-infection-how-long-should-we-wait-for-native-lung-recovery
#9
Gerard Cortina, Christian Niederwanger, Uwe Klingkowski, Corinna Velik-Salchner, Nikolaus Neu
Most children with severe respiratory failure require extracorporeal membrane oxygenation (ECMO) for 7-10 days. However, some may need prolonged duration ECMO (> 14 days). To date, no consensus exists on how long to wait for native lung recovery. Here we report the case of a 3-year-old boy who developed severe necrotizing pneumonia requiring venovenous (VV) ECMO after 19 days of mechanical ventilation. In the first 4 weeks of his ECMO run, he showed no lung aeration, requiring total extracorporeal support...
February 5, 2018: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/29301918/ers-ats-workshop-report-on-respiratory-health-effects-of-household-air-pollution
#10
Akshay Sood, Nour A Assad, Peter J Barnes, Andrew Churg, Stephen B Gordon, Kevin S Harrod, Hammad Irshad, Om P Kurmi, William J Martin, Paula Meek, Kevin Mortimer, Curtis W Noonan, Rogelio Perez-Padilla, Kirk R Smith, Yohannes Tesfaigzi, Tony Ward, John Balmes
Exposure to household air pollution (HAP) from solid fuel combustion affects almost half of the world population. Adverse respiratory outcomes such as respiratory infections, impaired lung growth and chronic obstructive pulmonary disease have been linked to HAP exposure. Solid fuel smoke is a heterogeneous mixture of various gases and particulates. Cell culture and animal studies with controlled exposure conditions and genetic homogeneity provide important insights into HAP mechanisms. Impaired bacterial phagocytosis in exposed human alveolar macrophages possibly mediates several HAP-related health effects...
January 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29230219/functional-impairment-of-mononuclear-phagocyte-system-by-the-human-respiratory-syncytial-virus
#11
REVIEW
Karen Bohmwald, Janyra A Espinoza, Raúl A Pulgar, Evelyn L Jara, Alexis M Kalergis
The mononuclear phagocyte system (MPS) comprises of monocytes, macrophages (MΦ), and dendritic cells (DCs). MPS is part of the first line of immune defense against a wide range of pathogens, including viruses, such as the human respiratory syncytial virus (hRSV). The hRSV is an enveloped virus that belongs to the Pneumoviridae family, Orthopneumovirus genus. This virus is the main etiological agent causing severe acute lower respiratory tract infection, especially in infants, children and the elderly. Human RSV can cause bronchiolitis and pneumonia and it has also been implicated in the development of recurrent wheezing and asthma...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29206639/electrical-impedance-tomography-in-children-with-community-acquired-pneumonia-preliminary-data
#12
Marta B Mazzoni, Alessandra Perri, Anna M Plebani, Silvia Ferrari, Giacomo Amelio, Alessia Rocchi, Dario Consonni, Gregorio P Milani, Emilio F Fossali
BACKGROUND: Electrical impedance tomography (EIT) is a noninvasive pulmonary function test that provides spatial and temporal information of changes in regional lung ventilation. We aimed to assess the feasibility of EIT as a supplementary tool in the evaluation of community acquired pneumonia in children. Furthermore, we performed a prospective evaluation of regional lung ventilation changes during a six-month follow-up period. METHODS: We enrolled otherwise healthy children aged 2-15 years with radiological diagnosis of community acquired pneumonia on admission at pediatric emergency department...
September 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/29199768/invasive-versus-non-invasive-ventilation-for-acute-respiratory-failure-in-neuromuscular-disease-and-chest-wall-disorders
#13
REVIEW
Fang Luo, Djillali Annane, David Orlikowski, Li He, Mi Yang, Muke Zhou, Guan J Liu
BACKGROUND: Acute respiratory failure is a common life-threatening complication of acute onset neuromuscular diseases, and may exacerbate chronic hypoventilation in patients with neuromuscular disease or chest wall disorders. Standard management includes oxygen supplementation, physiotherapy, cough assistance, and, whenever needed, antibiotics and intermittent positive pressure ventilation. Non-invasive mechanical ventilation (NIV) via nasal, buccal or full-face devices has become routine practice in many centres...
December 4, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28992427/effects-of-cannabinoid-receptor-type-2-in-respiratory-syncytial-virus-infection-in-human-subjects-and-mice
#14
Alireza Tahamtan, Yazdan Samieipoor, Fatemeh Sadat Nayeri, Ali Akbar Rahbarimanesh, Anahita Izadi, Ali Rashidi-Nezhad, Masoumeh Tavakoli-Yaraki, Mohammad Farahmand, Louis Bont, Fazel Shokri, Talat Mokhatri-Azad, Vahid Salimi
An accumulating body of evidence suggests that the endocannabinoid system plays a significant role in pathophysiological processes and impacts disease severity. Here we investigate the possible role of a cannabinoid receptor type 2 (CB2) functional variant in determining disease severity and the potential pharmacological therapeutic effects of CB2 activation in viral respiratory infection. The common missense variant (CAA/CGG; Q63R) of the gene-encoding CB2 receptor (CNR2) was evaluated in 90 inpatient and 90 outpatient children with acute respiratory tract infection (ARTI)...
January 1, 2018: Virulence
https://www.readbyqxmd.com/read/28861397/modulation-of-host-immunity-by-human-respiratory-syncytial-virus-virulence-factors-a-synergic-inhibition-of-both-innate-and-adaptive-immunity
#15
REVIEW
Gisela Canedo-Marroquín, Orlando Acevedo-Acevedo, Emma Rey-Jurado, Juan M Saavedra, Margarita K Lay, Susan M Bueno, Claudia A Riedel, Alexis M Kalergis
The Human Respiratory Syncytial Virus (hRSV) is a major cause of acute lower respiratory tract infections (ARTIs) and high rates of hospitalizations in children and in the elderly worldwide. Symptoms of hRSV infection include bronchiolitis and pneumonia. The lung pathology observed during hRSV infection is due in part to an exacerbated host immune response, characterized by immune cell infiltration to the lungs. HRSV is an enveloped virus, a member of the Pneumoviridae family, with a non-segmented genome and negative polarity-single RNA that contains 10 genes encoding for 11 proteins...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28777284/outcomes-of-primary-posterior-spinal-fusion-for-scoliosis-in-spinal-muscular-atrophy-clinical-radiographic-and-pulmonary-outcomes-and-complications
#16
Joshua B Holt, Lori A Dolan, Stuart L Weinstein
BACKGROUND: Spinal muscular atrophy (SMA) is a progressive neuromuscular disease commonly including progressive scoliosis resulting in severe deformity and negatively affecting pulmonary function. Surgical correction and stabilization of this progressive deformity is generally recommended; however, the timing and method of surgical fixation remains controversial. METHODS: Retrospective review of clinical, radiographic, and pulmonary function data from 16 children with SMA and surgically treated scoliosis between 1985 and 2013...
December 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28770121/necrotizing-pneumonia-an-emerging-problem-in-children
#17
REVIEW
I Brent Masters, Alan F Isles, Keith Grimwood
BACKGROUND: In children, necrotizing pneumonia (NP) is an uncommon, severe complication of pneumonia. It is characterized by destruction of the underlying lung parenchyma resulting in multiple small, thin-walled cavities and is often accompanied by empyema and bronchopleural fistulae. REVIEW: NP in children was first reported in children in 1994, and since then there has been a gradual increase in cases, which is partially explained by greater physician awareness and use of contrast computed tomography (CT) scans, and by temporal changes in circulating respiratory pathogens and antibiotic prescribing...
2017: Pneumonia
https://www.readbyqxmd.com/read/28731666/pulmonary-complications-of-chemical-pneumonia-a-case-report
#18
Semiha Bahceci Erdem, Hikmet T Nacaroglu, Rana Isgüder, Canan S Unsal Karkiner, Hüdaver Alper, Demet Can
Hydrocarbon aspiration (HA) can cause significant lung disease by inducing an inflammatory response, hemorrhagic exudative alveolitis, and loss of surfactant function. The most serious side effect of HA is aspiration pneumonia. Pneumothorax, pneumatocele, acute respiratory distress syndrome (ARDS), pulmonary abscess, bronchopleural fistula, bilateral hemorrhagic pleural effusion and pyopneumothorax were previously reported. Hereby we report a patient hospitalized due to aspiration pneumonia who developed pleurisy and pneumothorax after drinking paint thinner...
August 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28511647/low-smoke-chulha-in-indian-slums-study-protocol-for-a-randomised-controlled-trial
#19
RANDOMIZED CONTROLLED TRIAL
Megha Thakur, Esther A Boudewijns, Giridhara R Babu, Bjorn Winkens, Luc P de Witte, Jeroen Gruiskens, Preeti Sushama, Cristian T Ghergu, Onno C P van Schayck
BACKGROUND: Biomass fuel is used as a primary cooking source by more than half of the world's population, contributing to a high burden of disease. Although cleaner fuels are available, some households continue using solid fuels because of financial constraints and absence of infrastructure, especially in non-notified slums. The present study documents a randomised controlled study investigating the efficacy of improved cookstove on the personal exposure to air pollution and the respiratory health of women and children in an Indian slum...
May 16, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28269191/spectral-based-pneumonia-detection-tool-using-ultrasound-data-from-pediatric-populations
#20
O Zenteno, B Castaneda, R Lavarello
Pediatric Pneumonia is one of the principal causes of death by year on children under the age of five worldwide. The diagnosis is commonly made by clinical criteria with support from imaging tools like radiography. Lung ultrasound has been considered a low-cost and portable alternative for pneumonia imaging; however, interpretation is subjective and requires adequate training. In the present work, a pneumonia detection algorithm based on the measurement of the fundamental bandwidth downshift over depth of ultrasound radiofrequency (RF) signals is presented...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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