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Pneumonia & lung function children

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https://www.readbyqxmd.com/read/29301918/ers-ats-workshop-report-on-respiratory-health-effects-of-household-air-pollution
#1
Akshay Sood, Nour A Assad, Peter J Barnes, Andrew Churg, Stephen B Gordon, Kevin S Harrod, Hammad Irshad, Om P Kurmi, William J Martin, Paula Meek, Kevin Mortimer, Curtis W Noonan, Rogelio Perez-Padilla, Kirk R Smith, Yohannes Tesfaigzi, Tony Ward, John Balmes
Exposure to household air pollution (HAP) from solid fuel combustion affects almost half of the world population. Adverse respiratory outcomes such as respiratory infections, impaired lung growth and chronic obstructive pulmonary disease have been linked to HAP exposure. Solid fuel smoke is a heterogeneous mixture of various gases and particulates. Cell culture and animal studies with controlled exposure conditions and genetic homogeneity provide important insights into HAP mechanisms. Impaired bacterial phagocytosis in exposed human alveolar macrophages possibly mediates several HAP-related health effects...
January 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29230219/functional-impairment-of-mononuclear-phagocyte-system-by-the-human-respiratory-syncytial-virus
#2
REVIEW
Karen Bohmwald, Janyra A Espinoza, Raúl A Pulgar, Evelyn L Jara, Alexis M Kalergis
The mononuclear phagocyte system (MPS) comprises of monocytes, macrophages (MΦ), and dendritic cells (DCs). MPS is part of the first line of immune defense against a wide range of pathogens, including viruses, such as the human respiratory syncytial virus (hRSV). The hRSV is an enveloped virus that belongs to the Pneumoviridae family, Orthopneumovirus genus. This virus is the main etiological agent causing severe acute lower respiratory tract infection, especially in infants, children and the elderly. Human RSV can cause bronchiolitis and pneumonia and it has also been implicated in the development of recurrent wheezing and asthma...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29206639/electrical-impedance-tomography-in-children-with-community-acquired-pneumonia-preliminary-data
#3
Marta B Mazzoni, Alessandra Perri, Anna M Plebani, Silvia Ferrari, Giacomo Amelio, Alessia Rocchi, Dario Consonni, Gregorio P Milani, Emilio F Fossali
BACKGROUND: Electrical impedance tomography (EIT) is a noninvasive pulmonary function test that provides spatial and temporal information of changes in regional lung ventilation. We aimed to assess the feasibility of EIT as a supplementary tool in the evaluation of community acquired pneumonia in children. Furthermore, we performed a prospective evaluation of regional lung ventilation changes during a six-month follow-up period. METHODS: We enrolled otherwise healthy children aged 2-15 years with radiological diagnosis of community acquired pneumonia on admission at pediatric emergency department...
September 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/29199768/invasive-versus-non-invasive-ventilation-for-acute-respiratory-failure-in-neuromuscular-disease-and-chest-wall-disorders
#4
REVIEW
Fang Luo, Djillali Annane, David Orlikowski, Li He, Mi Yang, Muke Zhou, Guan J Liu
BACKGROUND: Acute respiratory failure is a common life-threatening complication of acute onset neuromuscular diseases, and may exacerbate chronic hypoventilation in patients with neuromuscular disease or chest wall disorders. Standard management includes oxygen supplementation, physiotherapy, cough assistance, and, whenever needed, antibiotics and intermittent positive pressure ventilation. Non-invasive mechanical ventilation (NIV) via nasal, buccal or full-face devices has become routine practice in many centres...
December 4, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28992427/effects-of-cannabinoid-receptor-type-2-in-respiratory-syncytial-virus-infection-in-human-subjects-and-mice
#5
Alireza Tahamtan, Yazdan Samieipoor, Fatemeh Sadat Nayeri, Ali Akbar Rahbarimanesh, Anahita Izadi, Ali Rashidi-Nezhad, Masoumeh Tavakoli-Yaraki, Mohammad Farahmand, Louis Bont, Fazel Shokri, Talat Mokhatri-Azad, Vahid Salimi
An accumulating body of evidence suggests that the endocannabinoid system plays a significant role in pathophysiological processes and impacts disease severity. Here we investigate the possible role of a cannabinoid receptor type 2 (CB2) functional variant in determining disease severity and the potential pharmacological therapeutic effects of CB2 activation in viral respiratory infection. The common missense variant (CAA/CGG; Q63R) of the gene-encoding CB2 receptor (CNR2) was evaluated in 90 inpatient and 90 outpatient children with acute respiratory tract infection (ARTI)...
October 9, 2017: Virulence
https://www.readbyqxmd.com/read/28861397/modulation-of-host-immunity-by-human-respiratory-syncytial-virus-virulence-factors-a-synergic-inhibition-of-both-innate-and-adaptive-immunity
#6
REVIEW
Gisela Canedo-Marroquín, Orlando Acevedo-Acevedo, Emma Rey-Jurado, Juan M Saavedra, Margarita K Lay, Susan M Bueno, Claudia A Riedel, Alexis M Kalergis
The Human Respiratory Syncytial Virus (hRSV) is a major cause of acute lower respiratory tract infections (ARTIs) and high rates of hospitalizations in children and in the elderly worldwide. Symptoms of hRSV infection include bronchiolitis and pneumonia. The lung pathology observed during hRSV infection is due in part to an exacerbated host immune response, characterized by immune cell infiltration to the lungs. HRSV is an enveloped virus, a member of the Pneumoviridae family, with a non-segmented genome and negative polarity-single RNA that contains 10 genes encoding for 11 proteins...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28777284/outcomes-of-primary-posterior-spinal-fusion-for-scoliosis-in-spinal-muscular-atrophy-clinical-radiographic-and-pulmonary-outcomes-and-complications
#7
Joshua B Holt, Lori A Dolan, Stuart L Weinstein
BACKGROUND: Spinal muscular atrophy (SMA) is a progressive neuromuscular disease commonly including progressive scoliosis resulting in severe deformity and negatively affecting pulmonary function. Surgical correction and stabilization of this progressive deformity is generally recommended; however, the timing and method of surgical fixation remains controversial. METHODS: Retrospective review of clinical, radiographic, and pulmonary function data from 16 children with SMA and surgically treated scoliosis between 1985 and 2013...
December 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28770121/necrotizing-pneumonia-an-emerging-problem-in-children
#8
REVIEW
I Brent Masters, Alan F Isles, Keith Grimwood
BACKGROUND: In children, necrotizing pneumonia (NP) is an uncommon, severe complication of pneumonia. It is characterized by destruction of the underlying lung parenchyma resulting in multiple small, thin-walled cavities and is often accompanied by empyema and bronchopleural fistulae. REVIEW: NP in children was first reported in children in 1994, and since then there has been a gradual increase in cases, which is partially explained by greater physician awareness and use of contrast computed tomography (CT) scans, and by temporal changes in circulating respiratory pathogens and antibiotic prescribing...
2017: Pneumonia
https://www.readbyqxmd.com/read/28731666/pulmonary-complications-of-chemical-pneumonia-a-case-report
#9
Semiha Bahceci Erdem, Hikmet T Nacaroglu, Rana Isgüder, Canan S Unsal Karkiner, Hüdaver Alper, Demet Can
Hydrocarbon aspiration (HA) can cause significant lung disease by inducing an inflammatory response, hemorrhagic exudative alveolitis, and loss of surfactant function. The most serious side effect of HA is aspiration pneumonia. Pneumothorax, pneumatocele, acute respiratory distress syndrome (ARDS), pulmonary abscess, bronchopleural fistula, bilateral hemorrhagic pleural effusion and pyopneumothorax were previously reported. Hereby we report a patient hospitalized due to aspiration pneumonia who developed pleurisy and pneumothorax after drinking paint thinner...
August 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28511647/low-smoke-chulha-in-indian-slums-study-protocol-for-a-randomised-controlled-trial
#10
RANDOMIZED CONTROLLED TRIAL
Megha Thakur, Esther A Boudewijns, Giridhara R Babu, Bjorn Winkens, Luc P de Witte, Jeroen Gruiskens, Preeti Sushama, Cristian T Ghergu, Onno C P van Schayck
BACKGROUND: Biomass fuel is used as a primary cooking source by more than half of the world's population, contributing to a high burden of disease. Although cleaner fuels are available, some households continue using solid fuels because of financial constraints and absence of infrastructure, especially in non-notified slums. The present study documents a randomised controlled study investigating the efficacy of improved cookstove on the personal exposure to air pollution and the respiratory health of women and children in an Indian slum...
May 16, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28269191/spectral-based-pneumonia-detection-tool-using-ultrasound-data-from-pediatric-populations
#11
O Zenteno, B Castaneda, R Lavarello
Pediatric Pneumonia is one of the principal causes of death by year on children under the age of five worldwide. The diagnosis is commonly made by clinical criteria with support from imaging tools like radiography. Lung ultrasound has been considered a low-cost and portable alternative for pneumonia imaging; however, interpretation is subjective and requires adequate training. In the present work, a pneumonia detection algorithm based on the measurement of the fundamental bandwidth downshift over depth of ultrasound radiofrequency (RF) signals is presented...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227421/spectral-based-pneumonia-detection-tool-using-ultrasound-data-from-pediatric-populations
#12
O Zenteno, B Castaneda, R Lavarello, O Zenteno, B Castaneda, R Lavarello, B Castaneda, O Zenteno, R Lavarello
Pediatric Pneumonia is one of the principal causes of death by year on children under the age of five worldwide. The diagnosis is commonly made by clinical criteria with support from imaging tools like radiography. Lung ultrasound has been considered a low-cost and portable alternative for pneumonia imaging; however, interpretation is subjective and requires adequate training. In the present work, a pneumonia detection algorithm based on the measurement of the fundamental bandwidth downshift over depth of ultrasound radiofrequency (RF) signals is presented...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28051240/clinical-effect-of-treating-secondary-asthma-attacks-of-children-mycoplasma-pneumoniae-with-combined-therapy-of-montelukast-and-azithromycin
#13
L Gong, L Xu, M Diao, F Guo, F-F Bian, J Min, R Liu, C-L Zhang
OBJECTIVE: To discuss the clinical effects of treating secondary asthma attacks of children Mycoplasma pneumoniae with combined therapy of montelukast and azithromycin. PATIENTS AND METHODS: 96 children patients diagnosed with secondary asthma attacks of Mycoplasma pneumonia were enrolled in this study. They were randomly divided into two groups: the control group (n=49) and the observation group (n=47). Patients in the control group received combined therapy using azithromycin and bronchodilators or glucocorticoid, and patients in the observation group received a combined therapy of montelukast, azithromycin and bronchodilators or glucocorticoid...
December 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27849230/primary-hypogammaglobulinemia-the-impact-of-early-diagnosis-in-lung-complications
#14
Mayra de Barros Dorna, Cristiane de Jesus Nunes Dos Santos, Ana Paula Beltran Moschione Castro, Luiz Antônio Nunes de Oliveira, Lisa Suzuki, Andrea Langone Ferme, Magda Maria Sales Carneiro-Sampaio, Antonio Carlos Pastorino
Objective: To describe clinical features, tomographic findings and pulmonary function in pediatric patients with primary hypogammaglobulinemia (PH). Method: A retrospective cohort study of children with PH who received intravenous immunoglobulin (IVIG) and prophylactic antibiotics between 2005 and 2010. Epidemiological and clinical features, computed tomography (CT) findings, and spirometric data were compared, assuming a 5% significance level. Results: We evaluated 30 patients with PH...
September 2016: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/27792269/impaired-immunosuppressive-effect-of-bronchoalveolar-mesenchymal-stem-cells-in-hypersensitivity-pneumonitis-preliminary-findings
#15
Enikő Balogh, Béla Nagy, Ágnes Gyetvai, Zsolt Bene, Zoltán Hendrik, Viktória Jeney, Péter Nagy, Ágnes Papp, József Balla, György Balla, János Kappelmayer, Béla Nagy
BACKGROUND: Bronchoalveolar mesenchymal stem cells (MSCs) play an important role in the maintenance of lung integrity. Therapeutic application of bone marrow-derived MSCs reduced chronic bronchial inflammation in idiopathic pulmonary fibrosis, and improved the ratio of survivors in sepsis with pneumonia. This study investigated the effect of MSCs from bronchoalveolar lavage fluid (BALF) of hypersensitivity pneumonitis (HP) on T-cell function under in vitro conditions. METHODS: Bronchoalveolar MSCs were obtained via bronchoscopy with BAL from children with severe subacute HP...
October 28, 2016: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/27455022/-pulmonary-surfactant-homeostasis-associated-genetic-abnormalities-and-lung-diseases
#16
REVIEW
Xiaojing Jiang, Xiuzhu Sun, Weihua Du, Haisheng Hao, Xueming Zhao, Dong Wang, Huabin Zhu, Yan Liu
Pulmonary surfactant (PS) is synthesized and secreted by alveolar epithelial type II (AEII) cells, which is a complex compound formed by proteins and lipids. Surfactant participates in a range of physiological processes such as reducing the surface tension, keeping the balance of alveolar fluid, maintaining normal alveolar morphology and conducting host defense. Genetic disorders of the surfactant homeostasis genes may result in lack of surfactant or cytotoxicity, and lead to multiple lung diseases in neonates, children and adults, including neonatal respiratory distress syndrome, interstitial pneumonia, pulmonary alveolar proteinosis, and pulmonary fibrosis...
August 2016: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
https://www.readbyqxmd.com/read/27427983/destabilized-smc5-6-complex-leads-to-chromosome-breakage-syndrome-with-severe-lung-disease
#17
Saskia N van der Crabben, Marije P Hennus, Grant A McGregor, Deborah I Ritter, Sandesh C S Nagamani, Owen S Wells, Magdalena Harakalova, Ivan K Chinn, Aaron Alt, Lucie Vondrova, Ron Hochstenbach, Joris M van Montfrans, Suzanne W Terheggen-Lagro, Stef van Lieshout, Markus J van Roosmalen, Ivo Renkens, Karen Duran, Isaac J Nijman, Wigard P Kloosterman, Eric Hennekam, Jordan S Orange, Peter M van Hasselt, David A Wheeler, Jan J Palecek, Alan R Lehmann, Antony W Oliver, Laurence H Pearl, Sharon E Plon, Johanne M Murray, Gijs van Haaften
The structural maintenance of chromosomes (SMC) family of proteins supports mitotic proliferation, meiosis, and DNA repair to control genomic stability. Impairments in chromosome maintenance are linked to rare chromosome breakage disorders. Here, we have identified a chromosome breakage syndrome associated with severe lung disease in early childhood. Four children from two unrelated kindreds died of severe pulmonary disease during infancy following viral pneumonia with evidence of combined T and B cell immunodeficiency...
August 1, 2016: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27399025/pulmonary-complications-of-chemical-pneumon%C3%A3-a-a-case-report
#18
Semiha Bahceci Erdem, Hikmet T Nacaroglu, Rana Isgüder, Canan S Unsal Karkiner, Hüdaver Alper, Demet Can
Hydrocarbon aspiration (HA) can cause significant lung disease by inducing an inflammatory response, hemorrhagic exudative alveolitis, and loss of surfactant function. The most serious side effect of HA is aspiration pneumonia. Pneumothorax, pneumatocele, acute respiratory distress syndrome (ARDS), pulmonary abscess, bronchopleural fistula, bilateral hemorrhagic pleural effusion and pyopneumothorax were previously reported. Hereby we report a patient hospitalized due to aspiration pneumonia who developed pleurisy and pneumothorax after drinking paint thinner...
August 1, 2016: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/27316915/french-intensive-care-society-international-congress-r%C3%A3-animation-2016
#19
(no author information available yet)
No abstract text is available yet for this article.
June 2016: Annals of Intensive Care
https://www.readbyqxmd.com/read/27277432/pulmonary-manifestation-of-immunoglobulin-g4-related-disease-in-a-7-year-old-immunodeficient-boy-with-epstein-barr-virus-infection-a-case-report
#20
Aleksandra Szczawinska-Poplonyk, Irena Wojsyk-Banaszak, Katarzyna Jonczyk-Potoczna, Anna Breborowicz
BACKGROUND: Immunoglobulin G4-related disease (IgG4-RD) is a multiorgan fibroinflammatory condition with lymphoplasmacytic infiltrates containing abundant IgG4-positive plasma cells. The immunopathogenesis of the disease and the potential role of triggering autoantigens or infectious factors have not been clearly defined. Immunoglobulin G4-related lung disease is a new and emerging condition in pediatric patients and to date, there have been only two reports regarding pulmonary manifestation of IgG4-RD in children recently published...
June 8, 2016: Italian Journal of Pediatrics
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