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https://www.readbyqxmd.com/read/28912711/increased-hippocampal-probdnf-contributes-to-memory-impairments-in-aged-mice
#1
Mona Buhusi, Chris Etheredge, Ann-Charlotte Granholm, Catalin V Buhusi
Memory decline during aging or accompanying neurodegenerative diseases, represents a major health problem. Neurotrophins have long been considered relevant to the mechanisms of aging-associated cognitive decline and neurodegeneration. Mature Brain-Derived Neurotrophic Factor (BDNF) and its precursor (proBDNF) can both be secreted in response to neuronal activity and exert opposing effects on neuronal physiology and plasticity. In this study, biochemical analyses revealed that increased levels of proBDNF are present in the aged mouse hippocampus relative to young and that the level of hippocampal proBDNF inversely correlates with the ability to perform in a spatial memory task, the water radial arm maze (WRAM)...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28900083/-the-effects-of-chronic-alcoholization-on-the-expression-of-brain-derived-neurotrophic-factor-and-its-receptors-in-the-brains-of-mice-genetically-predisposed-to-depressive-like-behavior
#2
D V Bazovkina, E M Kondaurova, A S Tsybko, A I Kovetskaya, T V Ilchibaeva, V S Naumenko
Brain-derived neurotropic factor (BDNF) plays an important role in mechanisms of depression. Precursor protein of this factor (proBDNF) can initiate apoptosis in the brain, while the mature form of BDNF is involved in neurogenesis. It is known that chronic alcoholization leads to the activation of apoptotic processes, neurodegeneration, brain injury, and cognitive dysfunction. In this work, we have studied the influence of long-term ethanol exposure on the proBDNF and BDNF protein levels, as well as on the expression of genes that encode these proteins in the brain structures of ASC mice with genetic predisposition to depressive-like behavior and in mice from parental nondepressive CBA strain...
July 2017: Molekuliarnaia Biologiia
https://www.readbyqxmd.com/read/28890399/activated-brain-derived-neurotrophic-factor-trkb-signaling-in-rat-dorsal-and-ventral-hippocampi-following-10-day-electroconvulsive-seizure-treatment
#3
Shingo Enomoto, Kunio Shimizu, Masashi Nibuya, Eiji Suzuki, Kiyoshi Nagata, Takashi Kondo
Electroconvulsive therapy (ECT) is still the most effective strategy to treat severe and drug-resistant depressive disorders. Electroconvulsive seizure (ECS), which induces neuroplastic structural alterations and resilient behavioral changes in experimental animals, is the model of the ECT for human depression. ECT is typically administered three times per week for up to 4 weeks, while ECS treatments are administered daily for 10days. The increased expression of hippocampal brain-derived neurotrophic factor (BDNF) induced by antidepressive ECS treatment in experimental animals has been well documented...
September 7, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28843509/walking-speed-decline-in-older-adults-is-associated-with-elevated-pro-bdnf-in-plasma-extracellular-vesicles
#4
Caitlin N Suire, Erez Eitan, Nancy Chiles Shaffer, Qu Tian, Stephanie Studenski, Mark P Mattson, Dimitrios Kapogiannis
BACKGROUND: Brain-derived neurotrophic factor (BDNF) is produced by cleavage of proBDNF, and BDNF and proBDNF may play antagonistic roles in nervous system development, learning, memory and neuronal stress resistance. BDNF and proBDNF are present in blood, but the origin and relative contributions of soluble and extracellular vesicle (EV)-associated levels are unknown. METHODS: In this study we used validated immunoassays to measure proBDNF and BDNF levels in plasma, total plasma EVs and a subpopulation of EVs enriched for neuronal origin (expressing the neuronal marker L1CAM) in 150 Baltimore Longitudinal Study of Aging participants with and without decline in walking speed (reflecting aging-associated motor decline)...
August 23, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28826637/sex-differences-in-the-effects-of-pre-and-postnatal-caffeine-exposure-on-behavior-and-synaptic-proteins-in-pubescent-rats
#5
Cássia Sallaberry, Ana Paula Ardais, Andréia Rocha, Maurício Felisberto Borges, Gabriela T Fioreze, Sabrina Mioranzza, Fernanda Nunes, Natália Pagnussat, Paulo Henrique S Botton, Lisiane O Porciúncula
Few studies have addressed the effects of caffeine in the puberty and/or adolescence in a sex dependent manner. Considering that caffeine intake has increased in this population, we investigated the behavioral and synaptic proteins changes in pubescent male and female rats after maternal consumption of caffeine. Adult female Wistar rats started to receive water or caffeine (0.1 and 0.3g/L in drinking water; low and moderate dose, respectively) during the active cycle at weekdays, two weeks before mating. The treatment lasted up to weaning and the offspring received caffeine until the onset of puberty (30-34days old)...
August 18, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28776309/morphine-withdrawal-increases-brain-derived-neurotrophic-factor-precursor
#6
Alessia Bachis, Lee A Campbell, Kierra Jenkins, Erin Wenzel, Italo Mocchetti
Morphine has been shown to increase the expression of brain-derived neurotrophic factor (BDNF) in the brain. However, little is known about the effect of morphine withdrawal on BDNF and its precursor protein, or proBDNF, which induces neuronal apoptosis. In this work, we examined whether BDNF and proBDNF levels change in rats chronically injected with escalating doses of morphine and those who undergo spontaneous withdrawal for 60 h. We observed, in the frontal cortex and striatum, that the ratio of BDNF to proBDNF changed depending upon the experimental paradigm...
August 3, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/28761093/combined-serum-levels-of-multiple-proteins-in-tpa-bdnf-pathway-may-aid-the-diagnosis-of-five-mental-disorders
#7
Suzhen Chen, Haitang Jiang, Yang Liu, Zhenhua Hou, Yingying Yue, Yuqun Zhang, Fuying Zhao, Zhi Xu, Yinghui Li, Xiaodong Mou, Lei Li, Tianyu Wang, Jingjing Zhao, Chongyang Han, Yuxiu Sui, Ming Wang, Zhong Yang, Yan Lu, Yifeng Zhu, Jianhua Li, Xinhua Shen, Fei Sun, Qingsong Chen, Huanxin Chen, Yonggui Yuan
Mental disorders are severe, disabling conditions with unknown etiology and are commonly misdiagnosed when clinical symptomology criteria are solely used. Our previous work indicated that combination of serum levels of multiple proteins in tissue plasminogen activator (tPA)-brain-derived neurotrophic factor (BDNF) pathway improved accuracy of diagnosis of major depressive disorder (MDD). Here, we measured serum levels of tPA, plasminogen activator inhibitor-1 (PAI-1), BDNF, precursor-BDNF (proBDNF), tropomyosin-related kinase B (TrkB) and neurotrophin receptor p75 (p75NTR) in patients with paranoid schizophrenia (SZ, n = 34), MDD (n = 30), bipolar mania (BM, n = 30), bipolar depression (BD, n = 22), panic disorder (PD, n = 30), and healthy controls (HCs, n = 30) by Enzyme-linked immunosorbent assay kits...
July 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28697556/probdnf-accelerates-brain-amyloid-%C3%AE-deposition-and-learning-and-memory-impairment-in-appsweps1de9-transgenic-mice
#8
Jia Chen, Tao Zhang, Shusheng Jiao, Xinfu Zhou, Jinhua Zhong, Yanjiang Wang, Juan Liu, Juan Deng, Shuiping Wang, Zhiqiang Xu
BACKGROUND: Alzheimer's disease (AD) is pathologically known for the amyloid-β (Aβ) deposition, neurofibrillary tangles, and neuronal loss in the brain. The precursor of brain-derived neurotrophic factor (proBDNF) before proteolysis has opposing functions to its mature form in neuronal survival and neurite growth. However, the role of proBDNF in the pathogenesis of AD remains unclear. OBJECTIVE: To investigate the effects of proBDNF on neurons in vitro, and on learning and memory impairment and brain Aβ production in a transgenic AD mouse model (APPswePS1dE9)...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28688339/brain-derived-neurotrophic-factor-signaling-plays-a-role-in-resilience-to-stress-promoted-by-isoquinoline-in-defeated-mice
#9
Ana Paula Pesarico, Suzan G Rosa, Franciele Martini, Tales A Goulart, Gilson Zeni, Cristina Wayne Nogueira
Certain stressful life events have been associated with the onset of depression. This study aims to investigate if 7-fluoro-1,3-diphenylisoquinoline-1-amine (FDPI) is effective against social avoidance induced by social defeat stress model in mice. Furthermore, it was investigated the effects of FDPI in the mouse prefrontal cortical plasticity-related proteins and some parameters of toxicity. Adult Swiss mice were subjected to social defeat stress for 10 days. Two protocols with FDPI were carried out: 1- FDPI (25 mg/kg, intragastric) was administered to mice 24 h after the last social defeat stress episode; 2- FDPI (1-25 mg/kg, intragastric) was administered to mice once a day for 10 days concomitant with the social defeat stress...
June 30, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28560687/hiv-1-gp120-upregulates-brain-derived-neurotrophic-factor-bdnf-expression-in-bv2-cells-via-the-wnt-%C3%AE-catenin-signaling-pathway
#10
Yongdi Wang, Jinxu Liao, Shao-Jun Tang, Jianhong Shu, Wenping Zhang
HIV-1 gp120 plays a critical role in the pathogenesis of HIV-associated pain, but the underlying molecular mechanisms are incompletely understood. This study aims to determine the effect and possible mechanism of HIV-1 gp120 on BDNF expression in BV2 cells (a murine-derived microglial cell line). We observed that gp120 (10 ng/ml) activated BV2 cells in cultures and upregulated proBDNF/mBDNF. Furthermore, gp120-treated BV2 also accumulated Wnt3a and β-catenin, suggesting the activation of the Wnt/β-catenin pathway...
June 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/28534952/effects-of-exercise-on-mature-or-precursor-brain%C3%A2-derived-neurotrophic-factor-pathways-in-ovariectomized-rats
#11
Joon-Ki Park, Young-Pyo Hong, Sam-Jun Lee
Ovariectomy (OVX) is a method used to block estrogen in female rats that induces hippocampal dysfunction and affects brain‑derived neurotrophic factor (BDNF) pathways. The majority of previous studies investigating OVX focused on BDNF expression in the hippocampus and cognitive function. The present study focused on the pathways of each BDNF type, precursor (proBDNF) and mature (mBDNF), and the effects of regular exercise in the hippocampus of ovariectomized rats. Female Sprague‑Dawely rats were used and OVX surgery was performed...
July 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28528122/probdnf-inhibits-proliferation-migration-and-differentiation-of-mouse-neural-stem-cells
#12
Jia-Yi Li, Jia Liu, Nimshitha Pavathuparambil Abdul Manaph, Larisa Bobrovskaya, Xin-Fu Zhou
ProBDNF, a precursor of brain-derived neurotrophic factor (BDNF), is an important regulator of neurodegeneration, hippocampal long-term depression, and synaptic plasticity. ProBDNF and its receptors pan-neurotrophin receptor p75 (p75NTR), vps10p domain-containing receptor Sortilin and tropomyosin receptor kinase B (TrkB) are expressed in neuronal and glial cells. The role of proBDNF in regulation of neurogenesis is not fully defined. This study aims to uncover the function of proBDNF in regulating the differentiation, migration and proliferation of mouse neural stem cells (NSCs) in vitro...
May 17, 2017: Brain Research
https://www.readbyqxmd.com/read/28509900/altered-expression-of-bdnf-bdnf-pro-peptide-and-their-precursor-probdnf-in-brain-and-liver-tissues-from-psychiatric-disorders-rethinking-the-brain-liver-axis
#13
B Yang, Q Ren, J-C Zhang, Q-X Chen, K Hashimoto
Brain-derived neurotrophic factor (BDNF) has a role in the pathophysiology of psychiatric disorders. The precursor proBDNF is converted to mature BDNF and BDNF pro-peptide, the N-terminal fragment of proBDNF; however, the precise function of these proteins in psychiatric disorders is unknown. We sought to determine whether expression of these proteins is altered in the brain and peripheral tissues from patients with psychiatric disorders. We measured protein expression of proBDNF, mature BDNF and BDNF pro-peptide in the parietal cortex, cerebellum, liver and spleen from control, major depressive disorder (MDD), schizophrenia (SZ) and bipolar disorder (BD) groups...
May 16, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28508317/trpc-channels-and-brain-inflammation
#14
REVIEW
Yoshito Mizoguchi, Akira Monji
Nonresolving low-grade inflammation is supposed to underly the basis of chronic disorders including cardiovascular diseases, cancer, diabetes, obesity, and psychiatric disorders such as depression and Alzheimer's diseases. There is increasing evidence suggesting that pathophysiology of psychiatric disorders is related to the inflammatory responses mediated by microglial cells. Elevation of intracellular Ca(2+) is important for the activation of microglial cell functions, including proliferation, release of NO, cytokines, and BDNF...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28466092/repeated-social-defeat-and-the-rewarding-effects-of-cocaine-in-adult-and-adolescent-mice-dopamine-transcription-factors-probdnf-signaling-pathways-and-the-trkb-receptor-in-the-mesolimbic-system
#15
Sandra Montagud-Romero, Cristina Nuñez, M Carmen Blanco-Gandia, Elena Martínez-Laorden, María A Aguilar, Javier Navarro-Zaragoza, Pilar Almela, Maria-Victoria Milanés, María-Luisa Laorden, José Miñarro, Marta Rodríguez-Arias
RATIONALE: Repeated social defeat (RSD) increases the rewarding effects of cocaine in adolescent and adult rodents. OBJECTIVE: The aim of the present study was to compare the long-term effects of RSD on the conditioned rewarding effects of cocaine and levels of the transcription factors Pitx3 and Nurr1 in the ventral tegmental area (VTA), the dopamine transporter (DAT), the D2 dopamine receptor (D2DR) and precursor of brain-derived neurotrophic factor (proBDNF) signaling pathways, and the tropomyosin-related kinase B (TrkB) receptor in the nucleus accumbens (NAc) in adult and adolescent mice...
July 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28456935/proneurotrophins-and-consequences
#16
REVIEW
Rui O Costa, Tânia Perestrelo, Ramiro D Almeida
Proneurotrophins were initially thought to be simple inactive precursors, only responsible for promoting the folding of the mature domain and for the regulation of the neurotrophin secretory pathway. However, recent evidence shows that proneurotrophins can be secreted to the extracellular space, bind with high affinity to specific receptor complexes and induce activation of the apoptotic machinery with subsequent cell death of different neuronal populations. These pathways can be activated due to injury and to several neurodegenerative disorders, which promote proneurotrophin secretion to the extracellular space...
April 29, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28375203/the-serum-protein-levels-of-the-tpa-bdnf-pathway-are-implicated-in-depression-and-antidepressant-treatment
#17
H Jiang, S Chen, C Li, N Lu, Y Yue, Y Yin, Y Zhang, X Zhi, D Zhang, Y Yuan
Evidence demonstrates that brain-derived neurotrophic factor (BDNF) has a pivotal role in the pathogenesis of major depressive disorder (MDD). Precursor-BDNF (proBDNF) and mature BDNF (mBDNF) have opposing biological effects in neuroplasticity, and the tissue-type plasminogen activator (tPA)/plasmin system is crucial in the cleavage processing of proBDNF to mBDNF. However, very little is known about the role of the tPA-BDNF pathway in MDD. We examined serum protein concentrations in the tPA-BDNF pathway, including tPA, BDNF, tropomyosin receptor kinase B (TrkB), proBDNF and p75NTR, obtained from 35 drug-free depressed patients before and after 8 weeks of escitalopram (mean 12...
April 4, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28330828/early-postnatal-iron-deficiency-impacts-plasticity-in-the-dorsal-and-ventral-hippocampus-in-piglets
#18
Ellis Nelissen, Jochen De Vry, Alexandra Antonides, Dean Paes, Melissa Schepers, Franz Josef van der Staay, Jos Prickaerts, Tim Vanmierlo
In this study, we investigated whether alterations in plasticity markers such as brain-derived neurotrophic factor (BDNF), p75 neurotrophin receptor (p75(NTR)) and tyrosine receptor kinase B (TrkB) are underlying iron deficiency (ID)-induced cognitive impairments in iron depleted piglets. Newborn piglets were either fed an iron-depleted diet (21mg Fe/kg) or an iron-sufficient diet (88mg Fe/kg) for four weeks. Subsequently, eight weeks after iron repletion (190-240mg Fe/kg) we found a significant decrease in mature BDNF (14kDa) and proBDNF (18kDa and 24kDa) protein levels in the ventral hippocampus, whereas we found increases in the dorsal hippocampus...
March 19, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/28289489/glioactive-atp-controls-bdnf-recycling-in-cortical-astrocytes
#19
Beatrice Vignoli, Marco Canossa
We have recently reported that long-term memory retention requires synaptic glia for proBDNF uptake and recycling. Through the recycling course, glial cells release endocytic BDNF, a mechanism that is activated in response to glutamate via AMPA and mGluRI/II receptors. Cortical astrocytes express receptors for many different transmitters suggesting for a complex signaling controlling endocytic BDNF secretion. Here, we demonstrated that the extracellular nucleotide ATP, activating P2X and P2Y receptors, regulates endocytic BDNF secretion in cultured astrocytes...
2017: Communicative & Integrative Biology
https://www.readbyqxmd.com/read/28284898/role-of-probdnf-and-bdnf-in-dendritic-spine-plasticity-and-depressive-like-behaviors-induced-by-an-animal-model-of-depression
#20
Hui Qiao, Shu-Cheng An, Chang Xu, Xin-Ming Ma
Major depressive disorder (MDD) is one of the most common psychiatric disorder, but the underlying mechanisms are largely unknown. Increasing evidence shows that brain-derived neurotrophic factor (BDNF) plays an important role in the structural plasticity induced by depression. Considering the opposite effects of BDNF and its precursor proBDNF on neural plasticity, we hypothesized that the balance of BDNF and proBDNF plays a critical role in chronic unpredicted mild stress (CUMS)-induced depressive-like behaviors and structural plasticity in the rodent hippocampus...
May 15, 2017: Brain Research
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