Mauro Pettorruso, Andrea Miuli, Katia Clemente, Gianluca Mancusi, Giuseppe Migliara, Francesco Di Carlo, Giulia Pernaci, Teresa Di Crosta, Mario Santorelli, Giacomo d'Andrea, Luisa De Risio, Mariaceleste Ciavarella, Valentina Baccolini, Ilenia Di Meo, Ivana Cataldo, Stefano L Sensi, Giovanni Martinotti
Brain-derived neurotrophic factor (BDNF) and its precursor, proBDNF, are known to significantly contribute to brain homeostasis, neuroplasticity, and neuronal remodeling. Although these neurotrophins are thought to have opposing roles, both play a critical part in shaping long-lasting behavioral changes following substance use. In this context, our study sought to explore the implications of these neurotrophins in the pathophysiology of cocaine use disorder (CUD). We conducted a case-control study, which included 28 individuals seeking treatment for CUD and 38 matched healthy participants...
January 4, 2024: Molecular Psychiatry