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Diabetology

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https://www.readbyqxmd.com/read/28063875/clinical-worthlessness-of-genetic-prediction-of-common-forms-of-diabetes-mellitus-and-related-chronic-complications-a-position-statement-of-the-italian-society-of-diabetology
#1
REVIEW
R Buzzetti, S Prudente, M Copetti, M Dauriz, S Zampetti, M Garofolo, G Penno, V Trischitta
AIM: We are currently facing several attempts aimed at marketing genetic data for predicting multifactorial diseases, among which diabetes mellitus is one of the more prevalent. The present document primarily aims at providing to practicing physicians a summary of available data regarding the role of genetic information in predicting diabetes and its chronic complications. DATA SYNTHESIS: Firstly, general information about characteristics and performance of risk prediction tools will be presented in order to help clinicians to get acquainted with basic methodological information related to the subject at issue...
August 26, 2016: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/28007789/reproductive-hormones-of-icsi-conceived-young-adult-men-the-first-results
#2
Florence Belva, Mathieu Roelants, Jean De Schepper, André Van Steirteghem, Herman Tournaye, Maryse Bonduelle
STUDY QUESTION: Are reproductive hormone levels (FSH, LH, inhibin B and testosterone) in male offspring conceived by ICSI because of male infertility comparable with those from peers born after spontaneous conception? SUMMARY ANSWER: In this cohort of 54 young men conceived by ICSI because of male-factor infertility, mean and median reproductive hormone levels were found to be comparable with results from spontaneously conceived peers, but ICSI-conceived men were more likely to have low inhibin B (<10th percentile) and high FSH (>90th percentile) levels...
December 21, 2016: Human Reproduction
https://www.readbyqxmd.com/read/28007439/patients-with-diabetes-are-at-high-risk-of-serious-medication-errors-at-hospital-interest-of-clinical-pharmacist-intervention-to-improve-healthcare
#3
Cyril Breuker, Océane Abraham, Laura di Trapanie, Thibault Mura, Valérie Macioce, Catherine Boegner, Anne Jalabert, Maxime Villiet, Audrey Castet-Nicolas, Antoine Avignon, Ariane Sultan
BACKGROUND: Medication errors (ME) are major public health issues in hospitals because of their consequences on patients' morbi-mortality. This study aims to evaluate the prevalence of ME at admission and discharge of hospitalization in diabetic and non-diabetic patients, and determine their potential clinical impact. METHOD: This prospective observational study was conducted at the Endocrinology-Diabetology-Nutrition Department. All adult patients admitted were eligible...
December 19, 2016: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/27991500/high-frequency-of-diabetic-ketoacidosis-at-diagnosis-of-type-1-diabetes-in-italian-children-a-nationwide-longitudinal-study-2004-2013
#4
Valentino Cherubini, Edlira Skrami, Lucia Ferrito, Stefano Zucchini, Andrea Scaramuzza, Riccardo Bonfanti, Pietro Buono, Francesca Cardella, Vittoria Cauvin, Giovanni Chiari, Giuseppe D Annunzio, Anna Paola Frongia, Dario Iafusco, Ippolita Patrizia Patera, Sonia Toni, Stefano Tumini, Ivana Rabbone, Fortunato Lombardo, Flavia Carle, Rosaria Gesuita
This longitudinal population-based study analyses the frequency of diabetic ketoacidosis (DKA) at type 1 diabetes diagnosis in Italian children under 15 years of age, during 2004-2013. DKA was defined as absent (pH ≥ 7.30), mild/moderate (7.1 ≤ pH < 7.30) and severe (pH < 7.1). Two multiple logistic regression models were used to evaluate the time trend of DKA frequency considered as present versus absent and severe versus absent, adjusted for gender, age group and geographical area of residence at diagnosis...
December 19, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27982492/possibilities-and-challenges-of-a-large-international-benchmarking-in-pediatric-diabetology-the-sweet-experience
#5
Michael Witsch, Ioanna Kosteria, Olga Kordonouri, Guy Alonso, Margarita Archinkova, Stephane Besancon, Niels H Birkebæk, Natasa Bratina, Valentino Cherubini, Ragnar Hanas, Dhruvi Hasnani, Violeta Iotova, João Filipe Raposo, Anke Schwandt, Zdenek Sumnik, Jannet Svensson, Henk Veeze
AIM: Despite the existence of evidence-based guidelines for the care of children with diabetes, widespread gaps in knowledge, attitude, and practice remain. The purpose of this paper is to present a review of benchmarking practices and results of this process within SWEET, moreover focusing on current challenges and future directions. METHODS: Biannually, members electronically transfer de-identified clinic data for 37 parameters to the SWEET database. Each center receives benchmarking and data validation reports...
October 2016: Pediatric Diabetes
https://www.readbyqxmd.com/read/27972231/increase-hospital-physicians-awareness-of-expenditure-generated-by-their-prescription-in-the-ambulatory-sector-learning-from-the-experience-of-the-37-public-hospitals-of-paris-in-diabetology
#6
F Bocquet, I Fusier, A Cordonnier, P Lechat, P Paubel
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27956024/joint-position-statement-on-nutraceuticals-for-the-treatment-of-hypercholesterolemia-of-the-italian-society-of-diabetology-sid-and-of-the-italian-society-for-the-study-of-arteriosclerosis-sisa
#7
REVIEW
M Pirro, C Vetrani, C Bianchi, M R Mannarino, F Bernini, A A Rivellese
AIM: Evidence showed that LDL-cholesterol lowering is associated with a significant cardiovascular risk reduction. The initial therapeutic approach to hypercholesterolemia includes dietary modifications but the compliance to recommendations is often inadequate. Some dietary components with potential cholesterol-lowering activity are present in small amounts in food. Therefore, in recent years the use of "nutraceuticals" (i.e., nutrients and/or bioactive compounds with potential beneficial effects on human health) has become widespread...
January 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/27921428/-promising-molecules-for-treatment-of-hyperglycemia-in-patients-with-type-2-diabetes
#8
Milan Kvapil
New antidiabetic drugs are being developed today that expand the range of pharmacological intervention, in particular for patients with type 2 diabetes (imeglimin, semaglutide, dulaglutide, FGF 21 analogue). At the same time innovations take place that "better" the well-proven molecules, they offer new application forms we have no experience of diabetology (osmotic pump for exenatide, faster acting insulin aspart). New properties are brought by just the change of concentration (insulin glargine in a concentration of 300 U/ml), unexpected positive results are also brought by new fixed-ratio combinations of antidiabetics (fixed-ratio combination of insulin degludec and liraglutide, fixed-ratio combination of insulin glargine and lixisenatide)...
2016: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/27885706/insulin-pump-failures-in-italian-children-with-type%C3%A2-1-diabetes-retrospective-1-year-cohort-study
#9
I Rabbone, N Minuto, R Bonfanti, M Marigliano, F Cerutti, V Cherubini, G d'Annunzio, A Frongia, D Iafusco, G Ignaccolo, F Lombardo, R Schiaffini, S Toni, S Tumini, S Zucchini, A Pistorio, A E Scaramuzza
AIMS: Insulin pump failure and/or malfunction requiring replacement have not been thoroughly investigated. This study evaluated pump replacement in children and adolescents with Type 1 diabetes using insulin pump therapy. METHODS: Data were collected for all participants younger than 19 years, starting insulin pump therapy before 31 December 2013. For each child, age, disease duration, date of insulin pump therapy initiation, insulin pump model, failure/malfunction/replacement yes/no and reason were considered for the year 2013...
November 25, 2016: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/27871293/genetic-and-epigenetic-alterations-in-the-gnas-locus-and-clinical-consequences-in-pseudohypoparathyroidism-italian-common-healthcare-pathways-adoption
#10
L de Sanctis, F Giachero, G Mantovani, G Weber, M Salerno, G I Baroncelli, M F Elli, P Matarazzo, M Wasniewska, L Mazzanti, G Scirè, D Tessaris
BACKGROUND: Genetic and epigenetic alterations in the GNAS locus are responsible for the Gsα protein dysfunctions causing Pseudohypoparathyroidism (PHP) type Ia/c and Ib, respectively. For these heterogeneous diseases characterized by multiple hormone resistances and Albright's Hereditary Osteodystrophy (AHO) the current classification results inadequate because of the clinical overlap between molecular subtypes and a standard clinical approach is still missing. In the present paper several members of the Study Group Endocrine diseases due to altered function of Gsα protein of the Italian Society of Pediatric Endocrinology and Diabetology (ISPED) have reviewed and updated the clinical-molecular data of the largest case series of (epi)/genetically characterized AHO/PHP patients; they then produced a common healthcare pathway for patients with these disorders...
November 21, 2016: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/27720361/link-between-nasal-carriage-of-staphylococcus%C3%A2-aureus-and-infected-diabetic-foot-ulcers
#11
C Dunyach-Remy, C Courtais-Coulon, C DeMattei, N Jourdan, S Schuldiner, A Sultan, C Carrière, S Alonso, A Sotto, J-P Lavigne
AIMS: Nasal carriage of Staphylococcus aureus in diabetic patients may be a risk factor for diabetic foot lesion infections. The aims of this study were to compare the genotypic profiles of S. aureus strains isolated from nares and diabetic foot ulcers (DFUs) using microarray technology. METHODS: Patients were included if they were admitted for diabetic foot infection (DFI) at any of three diabetology departments of Montpellier and Nîmes University Hospitals between 1 September 2010 to 30 June 2012...
October 5, 2016: Diabetes & Metabolism
https://www.readbyqxmd.com/read/27663668/delay-discounting-of-gains-and-losses-glycemic-control-and-therapeutic-adherence-in-type-2-diabetes
#12
Gaële Lebeau, Silla M Consoli, Raphael Le Bouc, Agnès Sola-Gazagnes, Agnès Hartemann, Dominique Simon, Gerard Reach, Jean-Jacques Altman, Mathias Pessiglione, Frédéric Limosin, Cédric Lemogne
OBJECTIVE: Delay discounting is the tendency to prefer smaller, sooner rewards to larger, later ones. Poor adherence in type 2 diabetes could be partially explained by a discounted value of health, as a function of delay. Delay discounting can be described with a hyperbolic model characterized by a coefficient, k. The higher k, the less future consequences are taken into account when making decisions. This study aimed to determine whether k would be correlated with glycated hemoglobin and adherence in type 2 diabetes...
November 2016: Behavioural Processes
https://www.readbyqxmd.com/read/27650214/causes-of-hospitalisation-and-prognosis-in-patients-with-cardiovascular-diseases-secular-trends-2006-2014-silesian-cardiovascular-silcard-database-covering-a-population-of-4-6-million-subjects
#13
Mariusz Gąsior, Damian Pres, Wojciech Wojakowski, Paweł Buszman, Zbigniew Kalarus, Michał Hawranek, Marek Gierlotka, Andrzej Lekston, Katarzyna Mizia-Stec, Marian Zembala, Lech Poloński, Michał Tendera
INTRODUCTION    Despite the progress that occurred in cardiology in the recent years, cardiovascular (CV) diseases still remain the main cause of death in European countries. The knowledge concerning the structure of hospital admissions for CV  diseases and clinical outcomes is fragmentary. OBJECTIVES    To analyse the characteristics and outcome of patients hospitalised with a CV diagnosis between 2006 and 2014, included in the Silesian Cardiovascular Database (SILCARD). PATIENTS AND METHODS    SILCARD is based on the data from the Regional Department of National Health Fund...
September 20, 2016: Polskie Archiwum Medycyny Wewnętrznej
https://www.readbyqxmd.com/read/27648047/measured-versus-calculated-ldl-cholesterol-in-subjects-with-type-2-diabetes
#14
Asher Fawwad, Rubina Sabir, Musarrat Riaz, Hassan Moin, Abdul Basit
OBJECTIVE: There is a strong positive association between increased low-density lipoprotein cholesterol (LDL-C) and coronary heart disease (CHD). The accuracy of LDL-C estimation is essential and critically important. The aim of present study was to compare calculated LDL-C with direct homogeneous assay in patients with type 2 diabetes. METHODS: This observational study was carried out at Baqai Institute of Diabetology and Endocrinology (BIDE) from January 2011 to December 2013...
July 2016: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/27627073/-autoimmune-insulitis-in-patients-with-type-2%C3%A2-diabetes-mellitus-a-randomized-clinical-trial-in-hospitalized-patients
#15
Emil Martinka, Mariana Rončáková, Michaela Mišániková, Arash Davani
BACKGROUND: It is not always easy to classify diabetes (DM) diagnosed in adults, with a significant group of patients initially classified and treated for type 2 diabetes mellitus (DM2T) presenting signs indicating the presence of autoimmune insulitis (AI), which is characteristic of type 1 diabetes mellitus (DM1T), or latent autoimmune diabetes mellitus in adults (LADA). GOAL: Identify the proportion of patients entered with DM2T who present AI signs, and the number of patients of that proportion, who at the same time present low insulin secretion, and what clinical and laboratory manifestations could be used to differentiate between these patients...
2016: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/27598916/-diabetes-in-pregnancy-type-1-type-2-diabetes-mellitus-and-gestational-diabetes-mellitus
#16
Helmut Kleinwechter, Norbert Demandt
In Germany in 5.5% of all births diabetes is registered. In patients with type 1 and type 2 diabetes planning pregnancy, preconception counseling, diabetologic care with optimized periconceptional metabolic control and folic acid supplementation are essential for good pregnancy outcome. Gestational diabetes (GDM) should be diagnosed timely and managed according to existing guidelines. GDM is treated with insulin in approximately 20%. In 1-2% of GDM cases a glucokinase gene mutation is present (MODY 2). Pregnancies after bariatric-metabolic surgery are increasing and show high risks...
September 2016: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/27598343/validation-of-prediction-models-for-near-adult-height-in-children-with-idiopathic-growth-hormone-deficiency-treated-with-growth-hormone-a-belgian-registry-study
#17
Saartje Straetemans, Jean De Schepper, Muriel Thomas, Franciska Verlinde, Raoul Rooman
BACKGROUND/AIM: To validate prediction models for near final adult height (nFAH) by Ranke et al. [Horm Res Paediatr 2013;79:51-67]. METHODS: Height data of 127 (82 male) idiopathic growth hormone (GH)-deficient children, treated with GH until nFAH, were retrieved from the database of the Belgian Society for Pediatric Endocrinology and Diabetology (BESPEED). nFAH was predicted after first-year GH treatment, applying prediction models by Ranke et al. Bland-Altman plots and Clarke error grid analyses were performed to assess clinical significance of the differences between observed and predicted nFAH...
2016: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/27585923/the-rehabilitation-of-children-and-adolescents-with-severe-or-medically-complicated-obesity-an-isped-expert-opinion-document
#18
Graziano Grugni, Maria Rosaria Licenziati, Giuliana Valerio, Antonino Crinò, Claudio Maffeis, Rita Tanas, Giuseppe Stefano Morino
Severe/medically complicated obesity in childhood, and particularly in adolescence, is a real disability that requires an intensive and continuous approach which should follow the procedures and schedule of rehabilitation medicine. Given the lack of a specific document focusing on children and adolescents, the Childhood Obesity Study Group set out to explore the available evidence for the treatment of severe or medically complicated obesity and to set standards tailored to the specific context of the Italian Health Service...
September 1, 2016: Eating and Weight Disorders: EWD
https://www.readbyqxmd.com/read/27535109/small-intestinal-bacterial-overgrowth-in-adult-patients-with-type-1-diabetes-its-prevalence-and-relationship-with-metabolic-control-and-the-presence-of-chronic-complications-of-the-disease
#19
Anna Adamska, Michalina Nowak, Stanisław Piłaciński, Aleksandra Araszkiewicz, Monika Litwinowicz, Małgorzata Tomaszewska, Bogna Wierusz-Wysocka, Marian Grzymisławski, Dorota Zozulińska-Ziółkiewicz
INTRODUCTION Gastrointestinal symptoms may occur in 50% to 70% of patients with diabetes. OBJECTIVES The aim of this study was to evaluate the prevalence of small intestinal bacterial overgrowth (SIBO) in patients with diabetes, as well as the relationship between SIBO and metabolic control of diabetes and the presence of chronic complications of the disease. PATIENTS AND METHODS The study group included 148 patients with type 1 diabetes, treated in the years 2013-2015. The control group consisted of 41 healthy volunteers...
August 18, 2016: Polskie Archiwum Medycyny Wewnętrznej
https://www.readbyqxmd.com/read/27526986/-chronic-kidney-failure-and-carotid-atherosclerosis-in-diabetic-patient
#20
Amal Moumen, Amal Bouziane, Azzelarab Meftah, Yassine Errahali, Hamza Eljadi, Souad Elmoussaoui, Ghizlaine Belmejdoub
INTRODUCTION: Chronic kidney failure is an independent risk factor of cardiovascular disease. Its association with carotid atherosclerosis remains controversial. The purpose of our study was to assess the factors associated with carotid atherosclerosis specially the components of chronic kidney disease. METHODS: In a cross-sectional study, we enrolled type 1 or type 2 diabetic patients from the endocrinology an diabetology department of the military hospital of Rabat assigned in two groups according to the presence or absence of carotid atherosclerosis...
September 2016: La Presse Médicale
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