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https://www.readbyqxmd.com/read/29999222/ispad-clinical-practice-consensus-guidelines-2018-compendium-insulin-treatment-in-children-and-adolescents-with-diabetes
#1
Thomas Danne, Moshe Phillip, Bruce Buckingham, Przemyslawa Jarosz-Chobot, Banshi Saboo, Tatsuhiko Urakami, Tadej Battelino, Ragnar Hanas, Ethel Codner
Refined recommendations on intensive regimens for differential substitution of basal and prandial insulin. Review of the role of new insulin analogs, biosimilars and devices for insulin therapy in pediatric diabetology are included. This article is protected by copyright. All rights reserved.
July 12, 2018: Pediatric Diabetes
https://www.readbyqxmd.com/read/29929497/internal-diseases-encountered-by-dental-students-while-treating-dental-patients-during-undergraduate-training
#2
Anja Humbert, Petra Schmage, Sigrid Harendza
BACKGROUND: The number of internal diseases, disorders and syndromes (IMDDSs) encountered in dental practice is increasing. Dentists report to feel ill prepared by their undergraduate dental training for the management of IMDDSs. To increase the effectiveness of internal medicine training at dental school it might be necessary to focus on IMDDs encountered by dental students. The aim of our study was to identify IMDDSs dental students come across while treating dental patients during the clinical years of their undergraduate training...
June 22, 2018: BMC Medical Education
https://www.readbyqxmd.com/read/29893044/insulin-pump-breakdown-and-infusion-set-failure-in-italian-children-with-type-1-diabetes-1-year-prospective-observational-study-with-suggestions-to-minimize-clinical-impact
#3
Ivana Rabbone, Nicola Minuto, Sonia Toni, Fortunato Lombardo, Dario Iafusco, Marco Marigliano, Riccardo Schiaffini, G Maltoni, Anna Paola Frongia, Marco Scardapane, Antonio Nicolucci, Valentino Cherubini, Riccardo Bonfanti, Andrea E Scaramuzza
AIMS: Incidence of insulin pump failures in a cohort of children and adolescents with type 1 diabetes was evaluated prospectively during a 1-yr follow-up. MATERIALS AND METHODS: Insulin pump breakdown and infusion set failures were prospectively registered in a cohort of 1046 children and adolescents from 25 tertiary pediatric diabetes centers (50% males, mean age 12.2±4.1 yrs), with type 1 diabetes since 6.7±3.6 yrs, and using insulin pump since 3.3±2.2 yrs...
June 12, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29890544/increased-oga-expression-and-activity-in-leukocytes-from-patients-with-diabetes-correlation-with-inflammation-markers
#4
Patrick Pagesy, Caroline Tachet, Ali Mostefa-Kara, Etienne Larger, Tarik Issad
O-linked-β-N-Acetylglucosaminylation (O-GlcNAcylation), a reversible post-translational modification involved in diabetic complications, is regulated by only two enzymes, O-linked N-acetylglucosamine transferase (OGT) and β-N-Acetylglucosaminidase (OGA). Increased OGA expression has been described previously in blood cells from patients with diabetes and was interpreted as an adaptative response to hyperglycemia-induced O-GlcNAcylation. OGA expression was thus proposed to have potential utility as a diagnostic marker...
June 11, 2018: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29886480/-child-adult-transition-adolescence-when-illness-appears%C3%A2
#5
Sabine Malivoir, Karinne Gueniche
Considering the patient's transition from child to adolescent to adult and its psychological aspects in endocrinology and diabetology, it is necessary to recall the child's psycho-affective development when he enters adolescence. Indeed, adolescence appears paradigmatic of the "child-adult" transition; it is a specific and decisive psychic process which allows the child to become an adult, that is to say autonomous and subject to his desire. In our paper, we study the resonance of a chronic disease in young people; type 1 diabetes is chosen...
2018: Endocrine Development
https://www.readbyqxmd.com/read/29884168/mortality-in-children-with-classic-congenital-adrenal-hyperplasia-and-21-hydroxylase-deficiency-cah-in-germany
#6
Helmuth G Dörr, Hartmut A Wollmann, Berthold P Hauffa, Joachim Woelfle
BACKGROUND: Adrenal crises in children with classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency (CAH) are life-threatening and have the potential to death. METHODS: A survey was performed among Paediatric Endocrinologists in Germany to report on deceased children with CAH. Our survey covered the whole of Germany. RESULTS: The participating centres reported 14 cases of death (9 female, 5 male) from 1973 until 2004, but no deaths thereafter...
June 8, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29866999/kidney-diseases-and-pregnancy-a-multidisciplinary-approach-for-improving-care-by-involving-nephrology-obstetrics-neonatology-urology-diabetology-bioethics-and-internal-medicine
#7
EDITORIAL
Giorgina Barbara Piccoli, Rossella Attini, Gianfranca Cabiddu
This multidisciplinary series is aimed at offering readers many opportunities to appreciate how a clinical and ethical approach to pregnancy has changed in patients with kidney diseases and with related conditions, including diabetes, hypertension, and immunologic diseases. Furthermore, this series aims to focus on the fact that many issues remain unreslved, that there are enormous gaps in knowledge, and that the bioethical approach needs to integrated in the clinical practice, which would allow for a deeper appreciation of different cultural and religious backgrounds...
June 4, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29786570/combination-of-metformin-and-pioglitazone-and-its-effect-in-treatment-of-comorbid-pathology
#8
Zlatoslava O Shaienko, Lyudmila Ye Bobyreva
OBJECTIVE: Introduction: The early development and high incidence of cardiovascular lesion in patients with type 2 diabetes mellitus is one of the most serious challenges for the diabetology worldwide. The aim: The purpose of the paper is to determine the dynamics of the insulin resistance indices in patients with type 2 diabetes mellitus concomitant with coronary heart disease in the combination therapy with metformin and pioglitazone during 3 and 6 months. PATIENTS AND METHODS: Materials and methods: 95 patients with type 2 diabetes mellitus and coronary heart disease have been treated and randomized into two groups: the comparison group (n=37), treated with metformin and sulfonylureas, and the study group (n=58), treated with metformin in combination with pioglitazone...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29761596/the-electronic-pharmaceutical-record-a-new-method-for-medication-reconciliation
#9
Camille Jurado, Violaine Calmels, Emilie Lobinet, Elodie Divol, Hélène Hanaire, David Metsu, Brigitte Sallerin
RATIONALE, AIM, AND OBJECTIVE: There are several ways to establish an accurate medication list in the hospital admission medication reconciliation (MedRec). The challenge for MedRec lies in the availability, reliability, and completeness of the data used. In France, the Electronic Pharmaceutical Record (ePR) was developed to register each medication taken by ambulatory patients, primarily to make dispensation in community pharmacies safe. We evaluated the suitability of this tool in the MedRec when patients were admitted to the hospital...
May 15, 2018: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/29743988/molecular-mechanisms-underlying-curcumin-mediated-therapeutic-effects-in-type-2-diabetes-and-cancer
#10
REVIEW
Marzena Wojcik, Michal Krawczyk, Pawel Wojcik, Katarzyna Cypryk, Lucyna Alicja Wozniak
The growing prevalence of age-related diseases, especially type 2 diabetes mellitus (T2DM) and cancer, has become global health and economic problems. Due to multifactorial nature of both diseases, their pathophysiology is not completely understood so far. Compelling evidence indicates that increased oxidative stress, resulting from an imbalance between production of reactive oxygen species (ROS) and their clearance by antioxidant defense mechanisms, as well as the proinflammatory state contributes to the development and progression of the diseases...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29731925/serum-apelin-a-new-marker-of-early-atherosclerosis-in-children-with-type-1-diabetes-mellitus
#11
Rania N Sabry, Maged A El Wakeel, Ghada M El-Kassas, Ahmed F Amer, Wael H El Batal, Salwa Refat El-Zayat, Mohamed Abou-El-Asrar
INTRODUCTION: Type 1 diabetes mellitus (T1DM) is one of the most common chronic diseases in children that may be complicated by micro or macrovascular complications. Measurement of the carotid intima-media thickness (CIMT) allows the early detection of atherosclerotic alterations of blood vessels that may complicate T1DM. SUBJECTS AND METHODS: This study is a case-control study. Participants were classified into two groups. The first group included 40 children with T1DM and the second group included 30 matched healthy controls...
April 15, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29696241/blood-pressure-and-metabolic-effects-of-acetyl-l-carnitine-in-type-2-diabetes-diabasi-randomized-controlled-trial
#12
Aneliya Parvanova, Matias Trillini, Manuel A Podestà, Ilian P Iliev, Carolina Aparicio, Annalisa Perna, Francesco Peraro, Nadia Rubis, Flavio Gaspari, Antonio Cannata, Silvia Ferrari, Antonio C Bossi, Roberto Trevisan, Sreejith Parameswaran, Jonathan S Chávez-Iñiguez, Fahrudin Masnic, Sidy Mohamed Seck, Teerayuth Jiamjariyaporn, Monica Cortinovis, Luca Perico, Kanishka Sharma, Giuseppe Remuzzi, Piero Ruggenenti, David G Warnock
Context: Acetyl-l-carnitine (ALC), a mitochondrial carrier involved in lipid oxidation and glucose metabolism, decreased systolic blood pressure (SBP), and ameliorated insulin sensitivity in hypertensive nondiabetic subjects at high cardiovascular risk. Objective: To assess the effects of ALC on SBP and glycemic and lipid control in patients with hypertension, type 2 diabetes mellitus (T2D), and dyslipidemia on background statin therapy. Design: After 4-week run-in period and stratification according to previous statin therapy, patients were randomized to 6-month, double-blind treatment with ALC or placebo added-on simvastatin...
May 1, 2018: Journal of the Endocrine Society
https://www.readbyqxmd.com/read/29686456/endocrinologists-opinions-of-diabetology-as-a-primary-care-subspecialty
#13
Amber M Healy, Jay H Shubrook, Frank L Schwartz, Doyle M Cummings, Almond J Drake, Robert J Tanenberg
IN BRIEF This study was conducted to ascertain the opinions of endocrinologists about diabetes care as it relates to the health care provider workforce. A survey was administered to endocrinologists in the Planning Research in Inpatient Diabetes and Planning Research in Outpatient Diabetes (PRIDE/PROUD) group and given to attendees of the American Diabetes Association (ADA) Scientific Sessions special interest group whose focus was primary care. The majority of respondents agreed that there is a need for more providers to be trained to take care of patients with diabetes and that more trained providers are needed, and almost half agreed that primary care providers (PCPs) with advanced training in diabetes should be part of the workforce for managing the diabetes pandemic...
April 2018: Clinical Diabetes: a Publication of the American Diabetes Association
https://www.readbyqxmd.com/read/29658280/-randomized-controlled-clinical-trials-with-observational-follow-up-investigations-for-evaluating-efficacy-of-antihyperglycaemic-treatment-ii-features-of-and-lessons-from-the-follow-up-investigations
#14
REVIEW
György Jermendy
Although the outcomes of the follow-up investigation period of the randomized clinical studies for evaluating the efficacy of a treatment or an antidiabetic drug may be confounded or potentially biased by several factors, the results are widely accepted by the diabetes community. In line with the theory of metabolic memory or metabolic legacy, early and intensive antihyperglycaemic treatment should be provided for all diabetic patients as this strategy can result in beneficial effects even in the long run. The recent cardiovascular safety trials with new, innovative antidiabetic drugs differ in several aspects from the former efficacy studies...
April 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/29631425/-randomized-controlled-clinical-trials-with-observational-follow-up-investigations-for-evaluating-efficacy-of-antihyperglycaemic-treatment-i-main-results-of-the-studies
#15
György Jermendy
The effect of antihyperglycaemic (antidiabetic) treatment on the late diabetic complications is one of the most important research areas in clinical diabetology. The relationship between glycaemic control and late micro- and macrovascular complications was highlighted by the results of the DCCT (Diabetes Control and Complications Trial) with type 1 and by the UKPDS (United Kingdom Prospective Diabetes Study) with type 2 diabetic patients. In these studies, observational follow-up investigations were also performed after the close-out of the randomized phase of the trial...
April 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/29629481/trace-elements-in-saliva-as-markers-of-type-2-diabetes-mellitus
#16
Luis Marín Martínez, Diana Molino Pagán, Pía López Jornet
To analyze Mg, Ca, and Zn levels in saliva, comparing patients with type 2 diabetes mellitus and a control group of healthy subjects. This transversal, observational, clinical study included a total sample of 147 patients, 74 with type 2 diabetes mellitus and a control group of 73 healthy subjects. Socio-demographic, anthropometric, diabetological, and metabolic variables were registered. Trace elements in non-stimulated basal saliva were measured using inductively coupled plasma mass spectrometry (ICP-MS): Mg, Ca, and Zn...
April 9, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29596952/diabetologists-and-oncologists-attitudes-towards-treating-diabetes-in-the-oncologic-patient-insights-from-an-exploratory-survey
#17
REVIEW
Gennaro Clemente, Marisa Giorgini, Marcello Mancini, Marco Gallo
AIMS: Diabetes and cancer frequently coexist in the same subject, often having relevant effects on the management and prognosis of the oncologic patient. However, existing guidelines do not deal with many clinical issues in this setting appropriately. In evaluating the opinions of Diabetologists and Oncologists dealing with diabetes care in people with cancer, the Italian Association of Diabetologists (AMD) promoted a dedicated exploratory survey. METHODS: The survey was carried out through the web or handily delivered printed copies between October 2014 and April 2015, in Italy...
March 26, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29575874/influence-of-growth-hormone-therapy-on-selected-dental-and-skeletal-system-parameters
#18
Małgorzata Partyka, Renata Chałas, Izabella Dunin-Wilczyńska, Myroslava Drohomyretska, Maria Klatka
INTRODUCTION: Growth hormone deficiency (GHD) is one of the main indications for growth hormone therapy. One characteristic of this disease is bone age delay in relation to the chronological age. Pituitary dysfunction negatively affects the growth and development of the jaws and teeth of the child. The secretion of endocrine glands regulates growth, development, and gender differentiation. It also controls the growth of bones and teeth, regulates metabolism of calcium and phosphate, proteins, lipids and carbohydrates...
March 14, 2018: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/29529689/frequency-of-blood-pressure-and-estimated-glomerular-filtration-rate-testing-in-type-2-diabetes-mellitus-a-retrospective-study-with-43-509-patients
#19
Karel Kostev, Alexander Lucas, Louis Jacob
BACKGROUND: The goal of this study was to analyze the frequency of blood pressure (BP) and estimated glomerular filtration rate (eGFR) testing in type 2 diabetes mellitus (T2DM) patients followed in general and diabetological practices in Germany. METHODS: The study included individuals who had at least two concultations due to T2DM diagnosis (ICD-10: E11) between January and December 2016. Patients were followed in 557 general and diabetological practices. The primary outcome was the frequency of BP and eGFR testing in T2DM patients in 2016...
March 12, 2018: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29527307/compliance-with-guidelines-for-disease-management-in-diabetes-results-from-the-swissdiab-registry
#20
Katrin E Schimke, Frida Renström, Sandro Meier, Christoph Stettler, Michael Brändle
Objective: Tight glycemic control and aggressive treatment of additional cardiovascular risk factors can substantially reduce risk of diabetes-related complications. In 2013, the Swiss Society of Endocrinology and Diabetology (SSED) established national criteria on good disease management in diabetes, but little is known about compliance in clinical care. Here we assessed to what extent patients from two tertiary care centers in the German-speaking part of Switzerland enrolled in the Swiss Diabetes (SwissDiab) Registry adhere to the SSED criteria...
2018: BMJ Open Diabetes Research & Care
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