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https://www.readbyqxmd.com/read/29458230/perioperative-complications-of-congenital-diaphragmatic-hernia-repair
#1
Catarina Barroso, Jorge Correia-Pinto
Although improvements have been made, the management of congenital diaphragmatic hernia (CDH) remains a major challenge for perinatologists and neonatal surgeons. Many aspects of the disease remain unknown and, being a rare entity, evidence-based data are hard to find. Surgical morbidity is considerable and affects long-term quality of life. Perioperative complications have been reviewed focusing on thoracoscopic repair. Intraoperative acidosis was more severe during thoracoscopy when compared with open surgery (OS), though it is possible that later neurodevelopment was not affected...
February 19, 2018: European Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29458000/evidence-for-a-mitochondrial-atp-regulated-potassium-channel-in-human-dermal-fibroblasts
#2
Piotr Bednarczyk, Anna Kicinska, Michal Laskowski, Bogusz Kulawiak, Rafal Kampa, Agnieszka Walewska, Milena Krajewska, Wieslawa Jarmuszkiewicz, Adam Szewczyk
Mitochondrial ATP-regulated potassium channels are present in the inner membrane of the mitochondria of various cells. In the present study, we show for the first time mitochondrial ATP-regulated potassium channels in human dermal fibroblast cells. Using the patch-clamp technique on the inner mitochondrial membrane of fibroblasts, we detected a potassium channel with a mean conductance equal to 100 pS in symmetric 150 mM KCl. The activity of this channel was inhibited by a complex of ATP/Mg2+ and activated by potassium channel openers such as diazoxide or BMS 191095...
February 16, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29457758/appraising-cervical-mucus-a-new-approach-to-evaluating-contraceptives
#3
Leo Han, Emily Padua, Alison Edelman, Jeffrey T Jensen
PURPOSE: Timing of sample collection represents a major source of variability in studies evaluating the effects of administered agents on cervical mucus in naturally-cycling women. We sought to create and validate an artificial model of the cervical mucus cycle using exogenous E2 and P4 replacement in ovarian suppressed women. MATERIALS AND METHODS: We conducted a prospective experiment (clinicaltrials.gov, NCT02969590) examining cervical mucus changes in six women during natural and artificial menstrual cycles [leuprolide acetate, estradiol transdermal patch (0...
February 19, 2018: European Journal of Contraception & Reproductive Health Care
https://www.readbyqxmd.com/read/29457485/atopy-associated-with-positive-patch-test-and-possible-allergic-contact-dermatitis
#4
Mark G Kirchhof, Gillian C de Gannes
BACKGROUND: Atopy is a genetic predisposition to the development of allergic reactions and the increased production of immunoglobulin E (IgE) upon exposure to environmental antigens. Clinical manifestations of atopy include asthma, atopic dermatitis (AD), and allergic rhinoconjunctivitis (ARC). OBJECTIVE: To determine if cutaneous delayed hypersensitivity reactions (CDHRs) as assessed by patch testing are higher among patients with a history of atopy and with a familial predisposition to atopy...
February 1, 2018: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29457017/distinct-trichoscopic-features-of-the-sideburns-in-frontal-fibrosing-alopecia-compared-to-the-frontotemporal-scalp
#5
Jessica Cervantes, Mariya Miteva
The trichoscopic features of frontal fibrosing alopecia (FFA) have been described in the frontotemporal area, yet there is no data detailing the trichoscopic features of the sideburns, which can be the initial or exclusive area of involvement. In this retrospective cohort study, 236 trichoscopic images of the frontotemporal and sideburn area obtained via dry trichoscopy from patients with biopsy-proven FFA were examined by two independent researchers to determine the trichoscopic features of FFA in the sideburns...
January 2018: Skin Appendage Disorders
https://www.readbyqxmd.com/read/29457011/trichoscopic-features-of-linear-morphea-on-the-scalp
#6
David Saceda-Corralo, Antonella Tosti
Linear scleroderma en coup de sabre (LSCS) is the most common form of morphea on the scalp and its trichoscopic features have not been described yet. We report 2 adult women with LSCS with distinct dermoscopic findings. They both had an atrophic well-defined linear patch of alopecia on the frontotemporal scalp. Dermoscopy showed loss of follicular openings on a whitish skin surface; scattered black dots, broken hairs, and pili torti; and short thick linear and branching tortuous vessels on the periphery of the lesion...
January 2018: Skin Appendage Disorders
https://www.readbyqxmd.com/read/29456510/sodium-tanshinone-ii-a-sulfonate-ds-201-induces-vasorelaxation-of-rat-mesenteric-arteries-via-inhibition-of-l-type-ca-2-channel
#7
Xiao-Dong Zhang, Chun-Xia He, Jun Cheng, Jing Wen, Peng-Yun Li, Na Wang, Guang Li, Xiao-Rong Zeng, Ji-Min Cao, Yan Yang
Background: We previously have proved that sodium tanshinone II-A sulfonate (DS-201), a derivative of traditional Chinese medicinal herb Danshen (Salvia miltiorrhiza), is an opener and vasodilator of BKCa channel in the vascular smooth muscle cells (VSMCs). Vascular tension is closely associated with Ca2+ dynamics and activation of BKCa channel may not be the sole mechanism for the relaxation of the vascular tension by DS-201. Therefore, we hypothesized that the vasorelaxing effect of DS-20 may be also related to Ca2+ channel and cytoplasmic Ca2+ level in the VSMCs...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29455819/resection-of-metastatic-hepatocellular-carcinoma-in-the-ventricular-septum-causing-left-ventricular-outflow-tract-obstruction
#8
W Hampton Gray, Rhusheet Patel, Craig J Baker, Vaughn A Starnes, Michael E Bowdish
Isolated cardiac involvement of recurrent metastatic hepatocellular carcinoma (HCC) is extremely rare. We report a patient with left ventricular outflow tract (LVOT) obstruction due to isolated recurrent HCC involving the interventricular septum (IVS). A ventriculotomy with resection of the tumor and patch repair of the IVS was performed with successful relief of LVOT obstruction. The patient was discharged home 6 days later symptom-free.
March 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29455516/core-shell-microneedle-gel-for-self-regulated-insulin-delivery
#9
Jinqiang Wang, Yanqi Ye, Jicheng Yu, Anna R Kahkoska, Xudong Zhang, Chao Wang, Wujin Sun, Ria D Corder, Zhaowei Chen, Saad A Khan, John B Buse, Zhen Gu
A bioinspired glucose-responsive insulin delivery system for self-regulation of blood glucose levels is desirable for improving health and quality of life outcomes for patients with type 1 and advanced type 2 diabetes. Here we describe a painless core-shell microneedle array patch consisting of degradable cross-linked gel for smart insulin delivery with rapid responsiveness and excellent biocompatibility. This gel-based device can partially dissociate and subsequently release insulin when triggered by hydrogen peroxide (H2 O2 ) generated during the oxidation of glucose by a glucose-specific enzyme covalently attached inside the gel...
February 19, 2018: ACS Nano
https://www.readbyqxmd.com/read/29455336/utilization-of-organic-nitrogen-by-arbuscular-mycorrhizal-fungi-is-there-a-specific-role-for-protists-and-ammonia-oxidizers
#10
Petra Bukovská, Michael Bonkowski, Tereza Konvalinková, Olena Beskid, Martina Hujslová, David Püschel, Veronika Řezáčová, María Semiramis Gutiérrez-Núñez, Milan Gryndler, Jan Jansa
Arbuscular mycorrhizal (AM) fungi can significantly contribute to plant nitrogen (N) uptake from complex organic sources, most likely in concert with activity of soil saprotrophs and other microbes releasing and transforming the N bound in organic forms. Here, we tested whether AM fungus (Rhizophagus irregularis) extraradical hyphal networks showed any preferences towards certain forms of organic N (chitin of fungal or crustacean origin, DNA, clover biomass, or albumin) administered in spatially discrete patches, and how the presence of AM fungal hyphae affected other microbes...
February 17, 2018: Mycorrhiza
https://www.readbyqxmd.com/read/29455257/finite-element-analysis-of-hollow-out-of-plane-hfo-2-microneedles-for-transdermal-drug-delivery-applications
#11
Yong-Hua Zhang, Stephen A Campbell, Sreejith Karthikeyan
Transdermal drug delivery (TDD) based on microneedles is an excellent approach due to its advantages of both traditional transdermal patch and hypodermic syringes. In this paper, the fabrication method of hollow out-of-layer hafnium oxide (HfO2 ) microneedles mainly based on deep reactive ion etching of silicon and atomic layer deposition of HfO2 is described, and the finite element analysis of the microneedles based on ANSYS software is also presented. The fabrication process is simplified by using a single mask...
February 17, 2018: Biomedical Microdevices
https://www.readbyqxmd.com/read/29455092/internet-pseudoscience-testing-opioid-containing-formulations-with-tampering-potential
#12
Jennifer P Pascali, Paolo Fais, Fabio Vaiano, Nicola Pigaiani, Stefano D'Errico, Sandra Furlanetto, Diego Palumbo, Elisabetta Bertol
Drug tampering practices, with the aim to increase availability of drug delivery and/or enhance drug effects, are accessible on Internet and are practiced by some portion of recreational drug users. Not rarely, recreational misuse may result in toxic and even fatal results. The aim of the present study was to assess the tampering risk of medicaments containing different formulations of an opioid in combination with paracetamol or dexketoprofen, following the procedures reported in dedicated forums on the web...
February 10, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29454884/illusory-edges-comingle-with-real-edges-in-the-neural-representation-of-objects
#13
Sarah L Elliott, Steven K Shevell
The visual system must transform a point-by-point biological representation from the photoreceptors into neural representations of separate objects. Even a uniform circular patch of light that slowly modulates in luminance can be segmented into separate central and surrounding areas merely by introducing black lines to outline a central square. The black lines cause brightness induction in the center even though the light inside and outside the square is always identical, as predicted by spatial antagonism between the square central area and its surround...
February 15, 2018: Vision Research
https://www.readbyqxmd.com/read/29454741/exploiting-or-overcoming-the-dome-trap-for-enhanced-oral-immunization-and-drug-delivery
#14
REVIEW
Jianping Qi, Jie Zhuang, Yongjiu Lv, Yi Lu, Wei Wu
The microfold cells (M cells) residing in the outmost follicle-associated epithelia (FAE) of Peyer's patches capture foreign particles and hand over to sub-FAE lymphatics, where the particles are retained and disposed subsequently. A concept of "dome trap" is proposed to highlight the significance of this mechanism. For oral immunization, it is better to exploit the entrapment capacity to maximize immune response, whereas for drug delivery it is better to overcome the dome trap to transport drugs into the systemic circulation...
February 15, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29454156/the-glun2b-subunit-represents-a-major-functional-determinant-of-nmda-receptors-in-human-induced-pluripotent-stem-cell-derived-cortical-neurons
#15
Ioana Neagoe, Chang Liu, Alexander Stumpf, Yanmei Lu, Dongping He, Ross Francis, Jun Chen, Paul Reynen, Moulay Hicham Alaoui-Ismaili, Hirokazu Fukui
Abnormal signaling pathways mediated by N-methyl-d-aspartate receptors (NMDARs) have been implicated in the pathogenesis of various CNS disorders and have been long considered as promising points of therapeutic intervention. However, few efforts have been previously described concerning evaluation of therapeutic modulators of NMDARs and their downstream pathways in human neurons with endogenous expression of NMDARs. In the present study, we assessed expression, functionality, and subunit composition of endogenous NMDARs in human induced pluripotent stem cell (hiPSC)-derived cortical neurons (iCell Neurons and iCell GlutaNeurons)...
February 8, 2018: Stem Cell Research
https://www.readbyqxmd.com/read/29453936/a-new-method-for-the-rapid-characterization-of-root-growth-and-distribution-using-digital-image-correlation
#16
Tan Bao, Garrett W Melenka, Megan K Ljubotina, Jason P Carey, James F Cahill
Rapidly determining root growth patterns is biologically important and technically challenging. Current methods focus on direct observation of roots and require destructive excavations or time-consuming root tracing. We developed a novel methodology based on analyzing soil particle displacement, rather than direct observation of roots. This inferred root growth method uses digital image correlation (DIC) analysis, an established and high-throughput method used in many engineering and science disciplines. By applying DIC analyses to repeated images of plants grown in clear window boxes, we produced visually intuitive and quantifiable strain maps, indicating the magnitude and direction of soil movement...
February 17, 2018: New Phytologist
https://www.readbyqxmd.com/read/29453767/increasing-connectivity-between-metapopulation-ecology-and-landscape-ecology
#17
Paige E Howell, Erin Muths, Blake R Hossack, Brent H Sigafus, Richard B Chandler
Metapopulation ecology and landscape ecology aim to understand how spatial structure influences ecological processes, yet these disciplines address the problem using fundamentally different modeling approaches. Metapopulation models describe how the spatial distribution of patches affects colonization and extinction, but often do not account for the heterogeneity in the landscape between patches. Models in landscape ecology use detailed descriptions of landscape structure, but often without considering colonization and extinction dynamics...
February 17, 2018: Ecology
https://www.readbyqxmd.com/read/29453407/neovasculature-can-be-induced-by-patching-an-arterial-graft-into-a-vein-a-novel-in-vivo-model-of-spontaneous-arteriovenous-fistula-formation
#18
Yukinobu Ito, Makoto Yoshida, Daichi Maeda, Masato Takahashi, Hiroshi Nanjo, Hirotake Masuda, Akiteru Goto
Arteriovenous malformations consist of tangles of arteries and veins that are often connected by a fistula. The causes and mechanisms of these clinical entities are not fully understood. We discovered that suturing an arterial patch into the common jugular vein of rabbits led to spontaneous neovascularization, the formation of an arteriovenous fistula and the development of an arteriovenous shunt. An arterial patch excised from the common carotid artery was sutured into the common jugular vein. Within a month, a dense nidus-like neovasculature formed around the patch...
February 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29453293/protein-phosphorylation-maintains-the-normal-function-of-cloned-human-ca-v-2-3-channels
#19
Felix Neumaier, Serdar Alpdogan, Jürgen Hescheler, Toni Schneider
R-type currents mediated by native and recombinant Ca v 2.3 voltage-gated Ca 2+ channels (VGCCs) exhibit facilitation (run-up) and subsequent decline (run-down) in whole-cell patch-clamp recordings. A better understanding of the two processes could provide insight into constitutive modulation of the channels in intact cells, but low expression levels and the need for pharmacological isolation have prevented investigations in native systems. Here, to circumvent these limitations, we use conventional and perforated-patch-clamp recordings in a recombinant expression system, which allows us to study the effects of cell dialysis in a reproducible manner...
February 16, 2018: Journal of General Physiology
https://www.readbyqxmd.com/read/29453198/targeting-kca1-1-channels-with-a-scorpion-venom-peptide-for-the-therapy-of-rat-models-of-rheumatoid-arthritis
#20
Mark R Tanner, Michael W Pennington, Brayden H Chamberlain, Redwan Huq, Elizabeth J Gehrmann, Teresina Laragione, Percio S Gulko, Christine Beeton
Fibroblast-like synoviocytes (FLS) are a key cell-type involved in rheumatoid arthritis (RA) progression. We previously identified the KCa1.1 potassium channel (Maxi-K, BK, Slo 1, KCNMA1) as a regulator of FLS and that KCa1.1 inhibition reduces disease severity in RA animal models. However, systemic KCa1.1 block causes multiple side effects and in this study, we aimed to determine whether the KCa1.1 β1-3-specific venom peptide blocker iberiotoxin (IbTX) reduces disease severity in animal models of RA without inducing major side effects...
February 16, 2018: Journal of Pharmacology and Experimental Therapeutics
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