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https://www.readbyqxmd.com/read/28650373/fentanyl-patch-not-adhering-properly-during-use
#1
Ann Shastay
No abstract text is available yet for this article.
July 2017: Home Healthcare Now
https://www.readbyqxmd.com/read/28650266/disease-suppressive-soils-new-insights-from-the-soil-microbiome
#2
Daniel Schlatter, Linda L Kinkel, Linda S Thomashow, David M Weller, Timothy Carl Paulitz
Soils suppressive to soilborne pathogens have been identified world-wide for almost 60 years and attributed mainly to suppressive or antagonistic microorganisms. Rather than identifying, testing and applying potential biocontrol agents in an inundative fashion, research into suppressive soils has attempted to understand how indigenous microbiomes can reduce disease, even in the presence of the pathogen, susceptible host, and favorable environment. Recent advances in next-generation sequencing of microbiomes have provided new tools to reexamine and further characterize the nature of these soils...
June 26, 2017: Phytopathology
https://www.readbyqxmd.com/read/28650234/antinociceptive-and-respiratory-effects-following-application-of-transdermal-fentanyl-patches-and-assessment-of-brain-%C3%AE-opioid-receptor-mrna-expression-in-ball-pythons
#3
Rima J Kharbush, Allison Gutwillig, Kate E Hartzler, Rebecca S Kimyon, Alyssa N Gardner, Andrew D Abbott, Sherry K Cox, Jyoti J Watters, Kurt K Sladky, Stephen M Johnson
OBJECTIVE To quantify plasma fentanyl concentrations (PFCs) and evaluate antinociceptive and respiratory effects following application of transdermal fentanyl patches (TFPs) and assess cerebrospinal μ-opioid receptor mRNA expression in ball pythons (compared with findings in turtles). ANIMALS 44 ball pythons (Python regius) and 10 turtles (Trachemys scripta elegans). PROCEDURES To administer 3 or 12 μg of fentanyl/h, a quarter or whole TFP (TFP-3 and TFP-12, respectively) was used. At intervals after TFP-12 application in snakes, PFCs were measured by reverse-phase high-pressure liquid chromatography...
July 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/28650116/polymeric-drug-delivery-systems-for-intraoral-site-specific-chemoprevention-of-oral-cancer
#4
REVIEW
Kashappa Goud H Desai
Oral cancer is among the most prevalent cancers in the world. Moreover, it is one of the major health problems and causes of death in many regions of the world. The traditional treatment modalities include surgical removal, radiation therapy, systemic chemotherapy, or a combination of these methods. In recent decades, there has been significant interest in intraoral site-specific chemoprevention via local drug delivery using polymeric systems. Because of its easy accessibility and clear visibility, the oral mucosa is amenable for local drug delivery...
June 26, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28650091/localized-micronutrient-patches-induce-lateral-root-foraging-and-chemotropism-in-nicotiana-attenuate
#5
Abigail P Ferrieri, Ricardo A R Machado, Carla C M Arce, Danny Kessler, Ian T Baldwin, Matthias Erb
Nutrients are distributed unevenly in the soil. Phenotypic plasticity in root growth and proliferation may enable plants to cope with this variation and effectively forage for essential nutrients. However, how micronutrients shape root architecture of plants in their natural environments is poorly understood. We employed a combination of field and laboratory-based assays to determine the capacity of Nicotiana attenuata to direct root growth towards localized nutrient patches in its native environment. Plants growing in nature displayed a particular root phenotype consisting of a single primary root and a few long, shallow lateral roots...
June 26, 2017: Journal of Integrative Plant Biology
https://www.readbyqxmd.com/read/28649945/how-noise-and-coupling-influence-leading-indicators-of-population-extinction-in-a-spatially-extended-ecological-system
#6
Suzanne M O'Regan
Anticipating critical transitions in spatially extended systems is a key topic of interest to ecologists. Gradually declining metapopulations are an important example of a spatially extended biological system that may exhibit a critical transition. Theory for spatially extended systems approaching extinction that accounts for environmental stochasticity and coupling is currently lacking. Here, we develop spatially implicit two-patch models with additive and multiplicative forms of environmental stochasticity that are slowly forced through population collapse, through changing environmental conditions...
June 25, 2017: Journal of Biological Dynamics
https://www.readbyqxmd.com/read/28649638/a-cubesat-centrifuge-for-long-duration-milligravity-research
#7
REVIEW
Erik Asphaug, Jekan Thangavelautham, Andrew Klesh, Aman Chandra, Ravi Nallapu, Laksh Raura, Mercedes Herreras-Martinez, Stephen Schwartz
We advocate a low-cost strategy for long-duration research into the 'milligravity' environment of asteroids, comets and small moons, where surface gravity is a vector field typically less than 1/1000 the gravity of Earth. Unlike the microgravity environment of space, there is a directionality that gives rise, over time, to strangely familiar geologic textures and landforms. In addition to advancing planetary science, and furthering technologies for hazardous asteroid mitigation and in situ resource utilization, simplified access to long-duration milligravity offers significant potential for advancing human spaceflight, biomedicine and manufacturing...
2017: NPJ Microgravity
https://www.readbyqxmd.com/read/28649470/determinants-of-seasonal-changes-in-availability-of-food-patches-for-elephants-loxodonta-africana-in-a-semi-arid-african-savanna
#8
Bruce W Clegg, Timothy G O'Connor
Loss of biodiversity caused by impact of elephants (Loxodonta africana) on African woodlands may require a management response, but any action should be based on an understanding of why elephants choose to utilise trees destructively. Comprehension of elephant feeding behaviour requires consideration of the relative value of the plant groups they may potentially consume. Profitability of available food is partly determined by the time to locate a food patch and, therefore, as a foundation for understanding the influence of food availability on diet selection, key controls on the density of grass, forb, and browse patches were investigated across space and time in a semi-arid African savanna...
2017: PeerJ
https://www.readbyqxmd.com/read/28649088/targeting-aggf1-angiogenic-factor-with-g-patch-and-fha-domains-1-for-blocking-neointimal-formation-after-vascular-injury
#9
Yufeng Yao, Zhenkun Hu, Jian Ye, Changqing Hu, Qixue Song, Xingwen Da, Yubin Yu, Hui Li, Chengqi Xu, Qiuyun Chen, Qing Kenneth Wang
BACKGROUND: Despite recent improvements in angioplasty and placement of drug-eluting stents in treatment of atherosclerosis, restenosis and in-stent thrombosis impede treatment efficacy and cause numerous deaths. Research efforts are needed to identify new molecular targets for blocking restenosis. We aim to establish angiogenic factor AGGF1 (angiogenic factor with G patch and FHA domains 1) as a novel target for blocking neointimal formation and restenosis after vascular injury. METHODS AND RESULTS: AGGF1 shows strong expression in carotid arteries; however, its expression is markedly decreased in arteries after vascular injury...
June 25, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28648667/simultaneous-recordings-of-intrinsic-cardiac-nerve-activities-and-skin-sympathetic-nerve-activities-from-human-patients-during-the-postoperative-period
#10
Mark J Shen, Arthur C Coffey, Susan Straka, David E Adams, David B Wagner, Richard J Kovacs, Michael Clark, Changyu Shen, Lan S Chen, Thomas H Everett, Shien-Fong Lin, Peng-Sheng Chen
BACKGROUND: Intrinsic cardiac nerve activities (ICNA) and the skin nerve activities (SKNA) are both associated with cardiac arrhythmias in dogs. OBJECTIVE: To test the hypothesis that ICNA and SKNA correlate with postoperative cardiac arrhythmias in humans. METHODS: Eleven patients (60±13 years old; 4 female) were enrolled in this study. Electrical signals were simultaneously recorded from electrocardiogram (ECG) patch electrodes on the chest wall and from two temporary pacing wires placed during open heart surgery on the left atrial epicardial fat pad...
June 22, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28648537/outcome-of-surgical-repair-of-pulmonary-artery-aneurysms-a-single-center-experience-with-38-patients
#11
Janani S Reisenauer, Sameh M Said, Hartzell V Schaff, Heidi M Connolly, Joseph J Maleszewski, Joseph A Dearani
BACKGROUND: Pulmonary artery (PA) aneurysms are rare and have been reported only in case reports or small series. We reviewed our experience with surgical repair of PA aneurysms. METHODS: We reviewed all patients with a true PA aneurysm undergoing cardiac operations between 1995 and 2015. We excluded aneurysms and pseudoaneurysms related to right ventricular outflow tract patches or previous conduits. RESULTS: There were 38 patients (24 women [63%]; mean age, 46 ± 15 years), and 14 patients (37%) were asymptomatic...
June 22, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28648480/a-10-year-institutional-experience-with-open-branched-graft-reconstruction-of-aortic-aneurysms-in-connective-tissue-disorders-versus-degenerative-disease
#12
Caitlin W Hicks, Jennifer Lue, Natalia O Glebova, Bryan A Ehlert, James H Black
OBJECTIVE: Aortic reconstruction for complex thoracoabdominal aortic aneurysms (TAAAs) can be challenging, especially in patients with connective tissue disorders (CTDs) in whom tissue fragility is a major concern. Branched graft reconstruction is a more complex operation compared with inclusion patch repair of the aorta but is frequently necessary in patients with CTDs or other pathologies because of anatomic reasons. We describe our institutional experience with open branched graft reconstruction of aortic aneurysms and compare outcomes for patients with CTDs vs degenerative pathologies...
June 22, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28648120/long-qt-syndrome-associated-caveolin-3-mutations-differentially-regulate-the-hyperpolarization-activated-cyclic-nucleotide-gated-channel-4
#13
L J Motloch, R Larbig, T Darabi, S Reda, K A Motloch, B Wernly, M Lichtenauer, T Gebing, A Schwaiger, N Zagidullin, M Wolny, U C Hoppe
Background Caveolin-3 (cav-3) mutations are linked to the long-QT syndrome (LQTS) causing distinct clinical symptoms. Hyperpolarization-activated cyclic nucleotide channel 4 (HCN4) underlies the pacemaker current If. It associates with cav-3 and both form a macromolecular complex. Methods To examine the effects of human LQTS-associated cav-3 mutations on HCN4-channel function, HEK293-cells were cotransfected with HCN4 and wild-type (WT) cav-3 or a LQTS-associated cav-3 mutant (T78M, A85T, S141R, or F97C). HCN4 currents were recorded using the whole-cell patch-clamp technique...
June 26, 2017: Physiology International
https://www.readbyqxmd.com/read/28648052/anti-cancer-therapeutic-alginate-based-tissue-sealants-for-lung-repair
#14
Spencer Lincoln Fenn, Patrick N Charron, Rachael Ann Oldinski
Injury to the connective tissue that lines the lung, the pleura, or to the lung itself can occur from many causes including trauma or surgery, as well as lung diseases or cancers. To address current limitations for patching lung injuries, to stop air or fluid leaks, an adherent hydrogel sealant patch system was developed, based on methacrylated alginate (AMA) and AMA di-aldehyde (AMA-DA) blends, which is capable of sealing damaged tissues and sustaining physiological pressures. Methacrylation of alginate hydroxyl groups rendered the polysaccharide capable of photo-crosslinking when mixed with an eosin Y-based photo-initiator system, and exposed to visible green light...
June 24, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28647638/evolution-of-practices-in-carotid-surgery-observational-study-in-france-from-2006-to-2015
#15
Lucie Salomon du Mont, Stefan Olteanu, Eric Steinmetz, Benjamin Kretz
INTRODUCTION: The principal objective of this study was to determine the evolution of the surgical management of stenosis of the carotid bifurcation over a period of 10 years in France. The secondary objective was to ascertain the impact of recommendations and of the literature on the evolution of these practices. MATERIALS AND METHODS: From the registry of the 'Agence Technique de l'Information sur l'Hospitalisation (ATIH)', we collected all of the data for carotid surgery procedures carried out in French healthcare establishments between 2006 and 2015...
June 21, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28647631/a-prospective-randomized-multicenter-clinical-trial-on-the-safety-and-efficacy-of-a-ready-to-use-fibrin-sealant-as-an-adjunct-to-hemostasis-during-vascular-surgery
#16
Ian Chetter, Gerard Stansby, José Aurelio Sarralde, Vicente Riambau, Antonio Giménez-Gaibar, Kent MacKenzie, Francisco Acín, Jordi Navarro-Puerto
PURPOSE: Anastomotic or "stitch hole" bleeding is common during vascular surgery with synthetic material such as Dacron or polytetrafluoroethylene (PTFE). Hemostatic adjuncts such as fibrin sealant (FS) may reduce blood loss and operating time in such circumstances. We evaluated the safety and the hemostatic effectiveness of a ready-to-use human plasma-derived FS in vascular surgery. METHODS: Patients with mild / moderate suture line bleeding during elective, open, vascular surgery using synthetic grafts or patches were studied...
June 21, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28647286/the-taper-corrosion-pattern-observed-for-one-bi-modular-stem-design-is-related-to-geometry-determined-taper-mechanics
#17
Dennis Buente, Michael Bryant, Michael Ward, Anne Neville, Michael Morlock, Gerd Huber
Bi-modular primary hip stems exhibit high revision rates owing to corrosion at the stem-neck taper, and are associated with local adverse tissue reactions. The aim of this study was to relate the wear patterns observed for one bi-modular design to its design-specific stem-neck taper geometry. Wear patterns and initial geometry of the taper junctions were determined for 27 retrieved bi-modular primary hip arthroplasty stems (Rejuvenate, Stryker Orthopaedics) using a tactile coordinate-measuring device. Regions of high-gradient wear patterns were additionally analyzed via optical and electron microscopy...
June 21, 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28646754/free-energy-analysis-of-cell-spreading
#18
Eóin McEvoy, Vikram S Deshpande, Patrick McGarry
In this study we present a steady-state adaptation of the thermodynamically motivated stress fiber (SF) model of Vigliotti et al. (2015). We implement this steady-state formulation in a non-local finite element setting where we also consider global conservation of the total number of cytoskeletal proteins within the cell, global conservation of the number of binding integrins on the cell membrane, and adhesion limiting ligand density on the substrate surface. We present a number of simulations of cell spreading in which we consider a limited subset of the possible deformed spread-states assumed by the cell in order to examine the hypothesis that free energy minimization drives the process of cell spreading...
June 7, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28646599/boldness-predicts-an-individual-s-position-along-an-exploration-exploitation-foraging-trade-off
#19
Samantha C Patrick, David Pinaud, Henri Weimerskirch
Individuals do not have complete information about the environment and therefore they face a trade-off between gathering information (exploration) and gathering resources (exploitation). Studies have shown individual differences in components of this trade-off but how stable these strategies are in a population and the intrinsic drivers of these differences is not well understood. Top marine predators are expected to experience a particularly strong trade-off as many species have large foraging ranges and their prey often have a patchy distribution...
June 24, 2017: Journal of Animal Ecology
https://www.readbyqxmd.com/read/28646241/never-forget-a-name-white-matter-connectivity-predicts-person-memory
#20
Athanasia Metoki, Kylie H Alm, Yin Wang, Chi T Ngo, Ingrid R Olson
Through learning and practice, we can acquire numerous skills, ranging from the simple (whistling) to the complex (memorizing operettas in a foreign language). It has been proposed that complex learning requires a network of brain regions that interact with one another via white matter pathways. One candidate white matter pathway, the uncinate fasciculus (UF), has exhibited mixed results for this hypothesis: some studies have shown UF involvement across a range of memory tasks, while other studies report null results...
June 23, 2017: Brain Structure & Function
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