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https://www.readbyqxmd.com/read/29245163/long-esophageal-inlet-patch-as-a-rare-cause-of-laryngopharyngeal-symptoms
#1
Władysław Januszewicz, Anna Pietrzak, Małgorzata Lenarcik, Andrzej Mróz, Jarosław Reguła
No abstract text is available yet for this article.
December 15, 2017: Endoscopy
https://www.readbyqxmd.com/read/29244790/lentivirus-mediated-silencing-of-the-ptc1-and-ptc2-genes-promotes-recovery-from-spinal-cord-injury-by-activating-the-hedgehog-signaling-pathway-in-a-rat-model
#2
Ya-Dong Zhang, Zhong-Sheng Zhu, Dong Zhang, Zhen Zhang, Bin Ma, Shi-Chang Zhao, Feng Xue
This study aimed to investigate the effect of Patched-1 (PTC1) and PTC2 silencing in a rat model, on Hedgehog (Hh) pathway-mediated recovery from spinal cord injury (SCI). An analytical emphasis on the relationship between the sonic hedgehog (Shh) pathway and nerve regeneration was explored. A total of 126 rats were divided into normal, sham, SCI, negative control (NC), PTC1-RNAi, PTC2-RNAi and PTC1/PTC2-RNAi groups. The Basso, Beattie and Bresnahan (BBB) scale was employed to assess hind limb motor function...
December 15, 2017: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29244742/fibrinogen-gamma-chain-mutations-provoke-fibrinogen-and-apolipoprotein-b-plasma-deficiency-and-liver-storage
#3
Francesco Callea, Isabella Giovannoni, Sinan Sari, Esendagli Guldal, Buket Dalgic, Gulen Akyol, Tsuyoshi Sogo, Abdulrahman Al-Hussaini, Giuseppe Maggiore, Andrea Bartuli, Renata Boldrini, Paola Francalanci, Emanuele Bellacchio
p.R375W (Fibrinogen Aguadilla) is one out of seven identified mutations (Brescia, Aguadilla, Angers, Al du Pont, Pisa, Beograd, and Ankara) causing hepatic storage of the mutant fibrinogen γ. The Aguadilla mutation has been reported in children from the Caribbean, Europe, Japan, Saudi Arabia, Turkey, and China. All reported children presented with a variable degree of histologically proven chronic liver disease and low plasma fibrinogen levels. In addition, one Japanese and one Turkish child had concomitant hypo-APOB-lipoproteinemia of unknown origin...
December 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29244556/seasonal-food-scarcity-prompts-long-distance-foraging-by-a-wild-social-bee
#4
Nathaniel S Pope, Shalene Jha
Foraging is an essential process for mobile animals, and its optimization serves as a foundational theory in ecology and evolution; however, drivers of foraging are rarely investigated across landscapes and seasons. Using a common bumblebee species from the western United States (Bombus vosnesenskii), we ask whether seasonal decreases in food resources prompt changes in foraging behavior and space use. We employ a unique integration of population genetic tools and spatially explicit foraging models to estimate foraging distances and rates of patch visitation for wild bumblebee colonies across three study regions and two seasons...
January 2018: American Naturalist
https://www.readbyqxmd.com/read/29243915/magnetic-patchy-janus-colloid-surfactants-for-reversible-recovery-of-pickering-emulsions
#5
Hyeri Kim, Jangwoo Cho, Jaehong Cho, Bum Jun Park, Jin Woong Kim
We present a straightforward and robust method for the synthesis of Janus colloid surfactants with distinct amphiphilicity and magnetic responsiveness. To this end, hydroxyl-functionalized amphiphilic Janus microparticles are synthesized by seeded monomer swelling and subsequent photo-polymerization. By incorporating controlled amounts of hydroxyl groups on poly (styrene-co-vinyl alcohol) seed particles, we adjust the interfacial tension between the seed polymer and the poly (tetradecyl acrylate) secondary polymer (γ13)...
December 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29242169/c60-fullerenes-disrupt-cellular-signalling-leading-to-trpc4-and-trpc6-channels-opening-by-the-activation-of-muscarinic-receptors-and-g-proteins-in-small-intestinal-smooth-muscles
#6
Dariia O Dryn, Mariia I Melnyk, Lina T Al Kury, Yuriy I Prylutskyy, Uwe Ritter, Alexander V Zholos
The effect of water-soluble pristine C60 fullerene nanoparticles (C60NPs) on receptor-operated cation channels formed by TRPC4/C6 proteins in ileal smooth muscle cells was investigated for the first time. Activation of these channels subsequent to acetylcholine binding to the expressed in these cells M2 and M3 muscarinic receptors represents the key event in the parasympathetic control of gastrointestinal smooth muscle motility and cholinergic excitation-contraction coupling. Experiments were performed on single collagenase-dispersed mouse ileal myocytes using patch-clamp techniques with symmetrical 125mM Cs+ solutions and [Ca2+]i 'clamped' at 100nM in order to isolate the muscarinic cation current (mICAT)...
December 11, 2017: Cellular Signalling
https://www.readbyqxmd.com/read/29241962/engineering-and-repair-of-diaphragm-using-biosheet-a-collagenous-connective-tissue-membrane-in-rabbits
#7
Keisuke Suzuki, Makoto Komura, Kan Terawaki, Tetsuro Kodaka, Takumi Gohara, Hiroko Komura, Yasuhide Nakayama
BACKGROUND: Prosthetic patches can be used to repair large congenital diaphragmatic hernia defects but may be associated with infection, recurrence, and thoracic deformity. Biosheets (collagenous connective tissue membranes) have been used in regenerative medicine. We evaluated the efficacy of Biosheets in a rabbit model. METHODS: Biosheets were prepared by embedding silicone plates in dorsal subcutaneous pouches of rabbits for 4weeks. In group 1 (n=11), Gore-Tex® sheets (1...
November 21, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29241771/alopecia-areata-disease-characteristics-clinical-evaluation-and-new-perspectives-on-pathogenesis
#8
REVIEW
Lauren C Strazzulla, Eddy Hsi Chun Wang, Lorena Avila, Kristen Lo Sicco, Nooshin Brinster, Angela M Christiano, Jerry Shapiro
Alopecia areata (AA) is a common, inflammatory, nonscarring type of hair loss. Significant variations in the clinical presentation of AA have been observed, ranging from small, well-circumscribed patches of hair loss to a complete absence of body and scalp hair. Patients affected by AA encompass all age groups, sexes, and ethnicities, and may experience frustration with the unpredictable nature of their disease for which there is currently no definitive treatment. The cause of AA remains incompletely understood, though it is believed to result-at least in part-from a loss of immune privilege in the hair follicle, autoimmune-mediated hair follicle destruction, and the upregulation of inflammatory pathways...
January 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29241653/synaptic-adaptations-to-chronic-ethanol-intake-in-male-rhesus-monkey-dorsal-striatum-depend-on-age-of-drinking-onset
#9
Verginia C Cuzon Carlson, Kathleen A Grant, David M Lovinger
One in 12 adults suffer with alcohol use disorder (AUD). Studies suggest the younger the age in which alcohol consumption begins the higher the probability of being diagnosed with AUD. Binge/excessive alcohol drinking involves a transition from flexible to inflexible behavior likely involving the dorsal striatum (caudate and putamen nuclei). A major focus of this study was to examine the effect of age of drinking onset on subsequent chronic, voluntary ethanol intake and dorsal striatal circuitry. Data from rhesus monkeys (n = 45) that started drinking as adolescents, young adults or mature adults confirms an age-related risk for heavy drinking...
December 12, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29241017/older-adult-multitasking-performance-using-a-gaze-contingent-useful-field-of-view
#10
Nathan Ward, John G Gaspar, Mark B Neider, James Crowell, Ronald Carbonari, Hank Kaczmarski, Ryan V Ringer, Aaron P Johnson, Lester C Loschky, Arthur F Kramer
Objective We implemented a gaze-contingent useful field of view paradigm to examine older adult multitasking performance in a simulated driving environment. Background Multitasking refers to the ability to manage multiple simultaneous streams of information. Recent work suggests that multitasking declines with age, yet the mechanisms supporting these declines are still debated. One possible framework to better understand this phenomenon is the useful field of view, or the area in the visual field where information can be attended and processed...
December 1, 2017: Human Factors
https://www.readbyqxmd.com/read/29240858/a-novel-multifactorial-approach-to-developing-mild-laundry-detergents-and-assessing-their-relative-mildnes
#11
Joseph F Fowler, Matthew J Zirwa J Zirwas, Lisa Napolitano, Meghan Russell, Janet Coope-Epstein
<p>INTRODUCTION: Dermatologists are becoming more aware of the irritant and allergic potential of laundry detergents that incorporate harsh surfactants and potentially sensitizing ingredients. It is difficult however for the physician to distinguish one laundry detergent from another because the only distinguishing feature advertised tends to be the lack of dyes and fragrances.</p> <p>DESIGN: A new objective method was developed for measuring the harshness of laundry detergents using a three-pronged laboratory testing approach consisting of zein, corneosurfametry, and cytokine testing...
December 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29240809/interaction-mode-of-cide-family-proteins-in-fly-drep1-and-drep3-acidic-surfaces-interact-with-drep2-and-drep4-basic-surfaces
#12
Chang Min Kim, Sun Hee Jeon, Jun-Hyuk Choi, Jun Hyuck Lee, Hyun Ho Park
Cell death-inducing DNA fragmentation factor 45 (DFF45)-like effector (CIDE) domains were initially identified as protein interaction modules in apoptotic nucleases and are now known to form a highly conserved family with diverse functions that range from cell death to lipid homeostasis. In the fly, four CIDE domain-containing proteins (DFF-related protein [DREP]-1-4) and their functions, including interaction relationships, have been identified. In this study, we introduced and investigated acidic side-disrupted mutants of DREP1, DREP2, and DREP3...
2017: PloS One
https://www.readbyqxmd.com/read/29240070/-method-of-forming-a-distal-anastomosis-with-an-autovenous-cuff
#13
A G Shalashov
Presented herein is a brief review of the world literature dedicated to methods of formation of composite arterial anastomoses in the femoropopliteal-tibial region The most justified is considered the use of a composite shunt formed proximally from a synthetic vascular graft made of polytetrafluoroethylene and distally with an extension from a portion of the suitable for reconstruction autovein (the so-called autovenous cuff of patch). The use of an autovenous cuff is more physiological since it provides closer correspondence of the diameters of the distal anastomosis being applied between the artery and autovenous extension, as well as contributes to creation of more adequate haemodynamic conditions in the shunt...
2017: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/29239964/superior-efficacy-of-lipid-emulsion-infusion-over-serum-alkalinization-in-reversing-amitriptyline-induced-cardiotoxicity-in-guinea-pig
#14
Shogo Tsujikawa, Tadashi Matsuura, Kotaro Hori, Takashi Mori, Miyuki Kuno, Kiyonobu Nishikawa
BACKGROUND: Tricyclic antidepressants (TCAs) are a major cause of fatal drug poisoning due to their cardiotoxicity. Alkalinization by sodium bicarbonate (NaHCO3) administration, the first-line therapy for TCA-induced cardiotoxicity, can occasionally yield insufficient efficacy in severe cases. Because most TCAs are highly lipophilic, lipid emulsion may be more effective than alkalinization. However, it remains to be determined whether lipid emulsion is more beneficial than alkalinization in reversing amitriptyline-induced cardiotoxicity...
December 11, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29239613/dewetting-of-thin-liquid-films-surrounding-air-bubbles-in-microchannels
#15
Sepideh Khodaparast, Omer Atasi, Antoine Deblais, Benoit Scheid, Howard A Stone
As an air bubble translates in a microchannel, a thin film of liquid is formed on the bounding walls. In a microchannel with a rectangular cross section, the liquid in the film leaks towards the low-pressure corners of the geometry, which leads to the appearance of local minima in the film thickness in the cross-sectional plane. In such a configuration, theory suggests that the minimum film thickness scales with Ca and Ca(4/3) depending on the distance from the nose of the bubble, where Ca = μUb/γ is the flow capillary number based on the bubble velocity Ub, liquid viscosity μ and surface tension γ...
December 14, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29239471/age-related-changes-in-the-morphology-and-the-distribution-of-iga-and-igg-in-the-palatine-tonsils-of-yaks-bos-grunniens
#16
Juan Sun, Yuanfang Xu, Yan Cui, Penggang Liu, Sijiu Yu, Junfeng He, Qian Zhang, Yufeng Huang, Xue Yang
This study aimed to describe the age-related morphological changes and the distribution of IgA and IgG antibody-secreting cells (ASCs) in yaks. The palatine tonsils of twenty clinically healthy yaks, viz. newborn juvenile, adult and aged, were studied using histology, immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). The results showed that the palatine tonsils found in two tonsillar sinus were elongated kidney-shaped structures. Some external crypts and internal crypts were present. The palatine tonsils were partially enclosed by a connective tissue capsule and had trabeculae extending into the organ...
December 14, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/29238552/taking-movement-data-to-new-depths-inferring-prey-availability-and-patch-profitability-from-seabird-foraging-behavior
#17
Marianna Chimienti, Thomas Cornulier, Ellie Owen, Mark Bolton, Ian M Davies, Justin M J Travis, Beth E Scott
Detailed information acquired using tracking technology has the potential to provide accurate pictures of the types of movements and behaviors performed by animals. To date, such data have not been widely exploited to provide inferred information about the foraging habitat. We collected data using multiple sensors (GPS, time depth recorders, and accelerometers) from two species of diving seabirds, razorbills (Alca torda, N = 5, from Fair Isle, UK) and common guillemots (Uria aalge, N = 2 from Fair Isle and N = 2 from Colonsay, UK)...
December 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/29238550/plant-community-composition-and-species-richness-in-the-high-arctic-tundra-from-the-present-to-the-future
#18
Jacob Nabe-Nielsen, Signe Normand, Francis K C Hui, Lærke Stewart, Christian Bay, Louise I Nabe-Nielsen, Niels Martin Schmidt
Arctic plant communities are altered by climate changes. The magnitude of these alterations depends on whether species distributions are determined by macroclimatic conditions, by factors related to local topography, or by biotic interactions. Our current understanding of the relative importance of these conditions is limited due to the scarcity of studies, especially in the High Arctic. We investigated variations in vascular plant community composition and species richness based on 288 plots distributed on three sites along a coast-inland gradient in Northeast Greenland using a stratified random design...
December 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/29237829/unexpected-functional-divergence-of-bat-influenza-virus-ns1-proteins
#19
Hannah L Turkington, Mindaugas Juozapaitis, Nikos Tsolakos, Eugenia Corrales-Aguilar, Martin Schwemmle, Benjamin G Hale
Recently, two influenza A virus (FLUAV) genomes were identified in Central and South American bats. These sequences exhibit notable divergence from classical FLUAV counterparts, and functionally, bat FLUAV glycoproteins lack canonical receptor binding and destroying activity. Nevertheless, other features that distinguish these viruses from classical FLUAVs have yet to be explored. Here, we studied the viral non-structural protein, NS1, a virulence factor that modulates host signaling to promote efficient propagation...
December 13, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29237777/ccl28-deficient-mice-have-reduced-iga-antibody-secreting-cells-and-an-altered-microbiota-in-the-colon
#20
Kazuhiko Matsuo, Daisuke Nagakubo, Shinya Yamamoto, Akiko Shigeta, Shuta Tomida, Mitsugu Fujita, Takako Hirata, Ikuo Tsunoda, Takashi Nakayama, Osamu Yoshie
CCL28 induces the migration of IgA Ab-secreting cells (ASCs) via CCR10 and also displays a potent antimicrobial activity in vitro. To explore the role of CCL28 in vivo, we generated CCL28-deficient mice. The mice exhibited a significant reduction and abnormal distribution of IgA ASCs in the lamina propria of the colon. The concentrations of total and Ag-specific IgA in the fecal extracts of CCL28-deficient mice were also drastically reduced. The average amount of IgA secreted by a single IgA ASC derived from the colon was also substantially reduced in CCL28-deficient mice...
December 13, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
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