keyword
https://read.qxmd.com/read/38431532/innovative-freeze-drying-technique-in-the-fabrication-of-dissolving-microneedle-patch-enhancing-transdermal-drug-delivery-efficiency
#21
JOURNAL ARTICLE
Tong Su, Zequn Tang, Jiayi Hu, Yuyu Zhu, Teng Shen
Microneedle patch (MNP) has become a hot research topic in the field of transdermal drug delivery due to its ability to overcome the stratum corneum barrier. Among the various types of microneedles, dissolving microneedles represent one of the most promising transdermal delivery methods. However, the most used method for preparing dissolving microneedles, namely microfabrication, suffers from issues such as long drying time, susceptibility to humidity, and large batch-to-batch variability, which limit the development of dissolving microneedles...
March 2, 2024: Drug Delivery and Translational Research
https://read.qxmd.com/read/38428314/mechanical-strength-affecting-the-penetration-in-microneedles-and-plga-nanoparticle-assisted-drug-delivery-importance-of-preparation-and-formulation
#22
JOURNAL ARTICLE
Geng Lu, Baohua Li, Luping Lin, Xiaofang Li, Junfeng Ban
Microneedles (MNs) prepared from polymeric materials are painless and minimally invasive, safe and efficient, but they hindered by low mechanical strength and single diverse drug release pattern. Due to the distinctive mechanical strength and dimensions of poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs), the integration of nano-technology with microneedles can effectively improve penetration and delivery efficiency through the stratum corneum. We herein designed a simple paroxetine (PAX)-loaded PLGA nanoparticles-integrated dissolving microneedles system (PAX-NPs-DMNs), aiming to improve the bioavailability of PAX through the synergistic permeation-enhancing effect of dissolving microneedles (DMNs) and NPs...
February 29, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38427917/rizatriptan-benzoate-loaded-dissolving-microneedle-patch-for-management-of-acute-migraine-therapy
#23
JOURNAL ARTICLE
Chao Zhong, Xiufeng Zhang, Yanfang Sun, Zhong Shen, Yanan Mao, Tianqi Liu, Rui Wang, Lei Nie, Amin Shavandi, Khaydar E Yunusov, Guohua Jiang
In this study, dissolving microneedles (MNs) using polyvinyl alcohol (PVA) and poly (1-vinylpyrrolidone-co-vinyl acetate) (P(VP-co-VA)) as matrix materials were developed for transdermal delivery of rizatriptan benzoate (RB) for acute migraine treatment. In-vitro permeation studies were conducted to assess the feasibility of the as-fabricated dissolving MNs to release RB. Drug skin penetration were tested by Franz diffusion cells, showing an increase of the transdermal flux compared to passive diffusion due to the as-fabricated dissolving MNs having a sufficient mechanical strength to penetrate the skin and form microchannels...
March 1, 2024: Journal of Biomaterials Applications
https://read.qxmd.com/read/38427095/characterization-of-percutaneous-absorption-of-calcium-magnesium-and-potentially-toxic-elements-in-two-tailored-sulfurous-therapeutic-peloids-a-comprehensive-in-vitro-pilot-study
#24
JOURNAL ARTICLE
Carla Marina Bastos, Fernando Rocha, Carla Patinha, Paula Marinho-Reis
Pelotherapy treatments in thermal spas, which utilize peloids composed of clay minerals mixed with saltwater or mineral-medicinal water, can have various effects on spa users, ranging from therapeutic to potential adverse reactions. Despite the widespread use of peloids, comprehensive information on the penetration and permeation of essential and potentially toxic elements into deeper layers of the skin during pelotherapy is limited. Understanding the concentrations of these elements is crucial for evaluating therapeutic benefits and ensuring safety...
March 1, 2024: International Journal of Biometeorology
https://read.qxmd.com/read/38416123/engineering-nanosystems-for-transdermal-delivery-of-antihypertensive-drugs
#25
REVIEW
Mingliang Fan, Wengang Liu, Liangfeng Zhao, Lirong Nie, Yu Wang
Abstract:To control hypertension, long-term continuous antihypertensive therapeutics are required and five classes of antihypertensive drugs are frequently involved, including diuretics, β-blockers, calcium channel blockers, angiotensin II receptor blockers, and angiotensin-converting enzyme inhibitors. Although with demonstrated clinical utility, there is still room for the improvement of many antihypertensive drugs in oral tablet or capsule dosage form, in terms of reducing systemic side effects and first-pass hepatic drug uptake...
February 28, 2024: Pharmaceutical Development and Technology
https://read.qxmd.com/read/38416058/recent-biomaterial-assisted-approaches-for-immunotherapeutic-inhibition-of-cancer-recurrence
#26
REVIEW
Negin Mozafari, Sheida Jahanbekam, Hajar Ashrafi, Mohammad-Ali Shahbazi, Amir Azadi
Biomaterials possess distinctive properties, notably their ability to encapsulate active biological products while providing biocompatible support. The immune system plays a vital role in preventing cancer recurrence, and there is considerable demand for an effective strategy to prevent cancer recurrence, necessitating effective strategies to address this concern. This review elucidates crucial cellular signaling pathways in cancer recurrence. Furthermore, it underscores the potential of biomaterial-based tools in averting or inhibiting cancer recurrence by modulating the immune system...
February 28, 2024: ACS Biomaterials Science & Engineering
https://read.qxmd.com/read/38415490/an-updated-review-on-nanoemulsion-factory-for-food-and-drug-delivery
#27
JOURNAL ARTICLE
Virender Kumar, Vandana Garg, Nakul Saini, Navidha Aggarwal, Harsh Kumar, Davinder Kumar, Hitesh Chopra, Mohammad Amjad Kamal, Harish Dureja
BACKGROUND: A nanoemulsion is a colloidal system of small droplets dispersed in another liquid. It has attracted considerable attention due to its unique properties and various applications. Throughout this review, we provide an overview of nanoemulsions and how they can be applied to various applications such as drug delivery, food applications, and pesticide formulations. OBJECTIVE: This updated review aims to comprehensively overview nanoemulsions and their applications as a versatile platform for drug delivery, food applications, and pesticide formulations...
February 23, 2024: Current Pharmaceutical Biotechnology
https://read.qxmd.com/read/38407993/application-of-biomaterials-in-the-development-of-hydrogel-forming-microneedles-integrated-with-a-cyclodextrin-drug-reservoir-for-improved-pharmacokinetic-profiles-of-telmisartan
#28
JOURNAL ARTICLE
Cindy Kristina Enggi, Sulistiawati Sulistiawati, Achmad Himawan, Muhammad Raihan, Israini Wiyulanda Iskandar, Rizki Rachmad Saputra, Latifah Rahman, Risfah Yulianty, Marianti A Manggau, Ryan F Donelly, Muhammad Aswad, Andi Dian Permana
Telmisartan (TEL) is a promising antihypertensive agent among other angiotensin receptor blockers. However, its oral application is limited by its poor water solubility. This study presents the successful utilization of biomaterial-based hydrogel-forming microneedles integrated with a direct compressed tablet reservoir (HFMN-DCT) for the transdermal delivery of telmisartan in the treatment of hypertension. The combination of PVP, PVA, and tartaric acid was used in the HFMN formulation. A range of cross-linking temperatures and times were employed to optimize the characteristics of the HFMN...
February 26, 2024: ACS Biomaterials Science & Engineering
https://read.qxmd.com/read/38407771/comparative-study-of-permeation-effects-between-vibrating-microneedle-and-low-frequency-sonophoresis-systems
#29
JOURNAL ARTICLE
Tingting Liu, Kai Chen, Zhigang Yan, Qiao Wang
Microneedle transdermal administration and low-frequency ultrasound represent two important physical penetration-promoting methods for enhancing drug penetration. This article aims to investigate and compare the effects of drug penetration enhancement through transdermal administration using vibrating microneedles versus low-frequency sonophoresis. In Vitro permeation studies were conducted using Valia-Chien double chamber diffusion cells to evaluate the transdermal delivery of tetramethylpyrazine hydrochloride (TMPH)...
February 26, 2024: Drug Delivery and Translational Research
https://read.qxmd.com/read/38399459/strategies-to-improve-cannabidiol-bioavailability-and-drug-delivery
#30
REVIEW
Saoirse Elizabeth O'Sullivan, Sanne Skov Jensen, Aditya Reddy Kolli, Gitte Nykjær Nikolajsen, Heidi Ziegler Bruun, Julia Hoeng
The poor physicochemical properties of cannabidiol (CBD) hamper its clinical development. The aim of this review was to examine the literature to identify novel oral products and delivery strategies for CBD, while assessing their clinical implications and translatability. Evaluation of the published literature revealed that oral CBD strategies are primarily focused on lipid-based and emulsion solutions or encapsulations, which improve the overall pharmacokinetics (PK) of CBD. Some emulsion formulations demonstrate more rapid systemic delivery...
February 13, 2024: Pharmaceuticals
https://read.qxmd.com/read/38399392/model-informed-drug-development-in-silico-assessment-of-drug-bioperformance-following-oral-and-percutaneous-administration
#31
REVIEW
Jelena Djuris, Sandra Cvijic, Ljiljana Djekic
The pharmaceutical industry has faced significant changes in recent years, primarily influenced by regulatory standards, market competition, and the need to accelerate drug development. Model-informed drug development (MIDD) leverages quantitative computational models to facilitate decision-making processes. This approach sheds light on the complex interplay between the influence of a drug's performance and the resulting clinical outcomes. This comprehensive review aims to explain the mechanisms that control the dissolution and/or release of drugs and their subsequent permeation through biological membranes...
January 30, 2024: Pharmaceuticals
https://read.qxmd.com/read/38399340/the-necessity-to-investigate-in-vivo-fate-of-nanoparticle-loaded-dissolving-microneedles
#32
REVIEW
Ziyao Chang, Yuhuan Wu, Ping Hu, Junhuang Jiang, Guilan Quan, Chuanbin Wu, Xin Pan, Zhengwei Huang
Transdermal drug delivery systems are rapidly gaining prominence and have found widespread application in the treatment of numerous diseases. However, they encounter the challenge of a low transdermal absorption rate. Microneedles can overcome the stratum corneum barrier to enhance the transdermal absorption rate. Among various types of microneedles, nanoparticle-loaded dissolving microneedles (DMNs) present a unique combination of advantages, leveraging the strengths of DMNs (high payload, good mechanical properties, and easy fabrication) and nanocarriers (satisfactory solubilization capacity and a controlled release profile)...
February 17, 2024: Pharmaceutics
https://read.qxmd.com/read/38399321/the-evolution-of-emerging-nanovesicle-technologies-for-enhanced-delivery-of-molecules-into-and-across-the-skin
#33
REVIEW
Elka Touitou, Hiba Natsheh
This review focuses on nanovesicular carriers for enhanced delivery of molecules into and across the skin, from their design to recent emerging technologies. During the last four decades, several approaches have been used aiming to design new nanovesicles, some of them by altering the properties of the classic phospholipid vesicle, the liposome. Phospholipid nanovesicular systems, including the phospholipid soft vesicles as well as the non-phospholipid vesicular carries, are reviewed. The altered nanovesicles have served in the manufacture of various cosmetic products and have been investigated and used for the treatment of a wide variety of skin conditions...
February 13, 2024: Pharmaceutics
https://read.qxmd.com/read/38399276/delivery-strategies-for-colchicine-as-a-critical-dose-drug-reducing-toxicity-and-enhancing-efficacy
#34
REVIEW
Yaran Lei, Yulu Yang, Guobao Yang, Ao Li, Yang Yang, Yuli Wang, Chunsheng Gao
Colchicine (COL), a widely used natural drug, has potent anti-inflammatory effects; however, as a narrow therapeutic index drug, its clinical application is limited by its serious gastrointestinal adverse effects, and only oral formulations are currently marketed worldwide. Recent studies have shown that transdermal, injection, and oral drug delivery are the three main delivery strategies for COL. This article elaborates on the research progress of different delivery strategies in terms of toxicity reduction and efficacy enhancement, depicting that the transdermal drug delivery route can avoid the first-pass effect and the traumatic pain associated with the oral and injection routes, respectively...
February 3, 2024: Pharmaceutics
https://read.qxmd.com/read/38399254/mechanical-characterization-of-dissolving-microneedles-factors-affecting-physical-strength-of-needles
#35
JOURNAL ARTICLE
Daisuke Ando, Megumi Miyatsuji, Hideyuki Sakoda, Eiichi Yamamoto, Tamaki Miyazaki, Tatsuo Koide, Yoji Sato, Ken-Ichi Izutsu
Dissolving microneedles (MNs) are novel transdermal drug delivery systems that can be painlessly self-administered. This study investigated the effects of experimental conditions on the mechanical characterization of dissolving MNs for quality evaluation. Micromolding was used to fabricate polyvinyl alcohol (PVA)-based dissolving MN patches with eight different cone-shaped geometries. Axial force mechanical characterization test conditions, in terms of compression speed and the number of compression needles per test, significantly affected the needle fracture force of dissolving MNs...
January 30, 2024: Pharmaceutics
https://read.qxmd.com/read/38399221/the-fabrication-of-polymer-based-curcumin-loaded-formulation-as-a-drug-delivery-system-an-updated-review-from-2017-to-the-present
#36
REVIEW
Abul Kalam Azad, Joanne Lai, Wan Mohd Azizi Wan Sulaiman, Hassan Almoustafa, Salah Abdalrazak Alshehade, Vinoth Kumarasamy, Vetriselvan Subramaniyan
Turmeric contains curcumin, a naturally occurring compound with noted anti-inflammatory and antioxidant properties that may help fight cancer. Curcumin is readily available, nontoxic, and inexpensive. At high doses, it has minimal side effects, suggesting it is safe for human use. However, curcumin has extremely poor bioavailability and biodistribution, which further hamper its clinical applications. It is commonly administered through oral and transdermal routes in different forms, where the particle size is one of the most common barriers that decreases its absorption through biological membranes on the targeted sites and limits its clinical effectiveness...
January 24, 2024: Pharmaceutics
https://read.qxmd.com/read/38398519/establishment-and-validation-of-a-transdermal-drug-delivery-system-for-the-anti-depressant-drug-citalopram-hydrobromide
#37
JOURNAL ARTICLE
Yi-Yang Sun, Ya-Jing Ni, Run-Jia Wang, Zi-Cheng Qin, Zhao Liu, Li-Hui Xiao, Yan-Qiang Liu
To enhance the bioavailability and antihypertensive effect of the anti-depressant drug citalopram hydrobromide (CTH) we developed a sustained-release transdermal delivery system containing CTH. A transdermal diffusion meter was first used to determine the optimal formulation of the CTH transdermal drug delivery system (TDDS). Then, based on the determined formulation, a sustained-release patch was prepared; its physical characteristics, including quality, stickiness, and appearance, were evaluated, and its pharmacokinetics and irritation to the skin were evaluated by applying it to rabbits and rats...
February 7, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38391788/a-review-of-amphetamine-extended-release-once-daily-options-for-the-management-of-attention-deficit-hyperactivity-disorder
#38
REVIEW
Kendall Abbas, Elizabeth W Barnhardt, Patricia L Nash, Maria Streng, Daniel L Coury
INTRODUCTION: Amphetamine preparations are one of the two categories of stimulant medications approved for the treatment of attention deficit hyperactivity disorder (ADHD). Optimal treatment of ADHD aims to reduce core symptoms for as much of the waking hours as possible, leading to longer-acting delivery formats. In addition, the pediatric population commonly has difficulty swallowing pills and manufacturers have developed a variety of options to facilitate this concern. These include chewable tablets, capsules that may be sprinkled on soft food, liquids and transdermal patches...
April 2024: Expert Review of Neurotherapeutics
https://read.qxmd.com/read/38385494/technical-considerations-applications-and-benefits-of-organogels-in-topical-drug-delivery-systems
#39
JOURNAL ARTICLE
Abhishek Yadav, Vikas Jhawat, Rahul Pratap Singh, Sunita Chauhan, Rohit Dutt, Rajesh Goyal, Deependra Singh
Organogels represent semi-solid systems where an organic liquid phase is entrapped within a three-dimensional network formed by self-assembled, crosslinked, or entangled gelator fibers. These versatile materials find applications in a wide range of fields, including chemistry, pharmaceuticals, cosmetics, biotechnology, and food technology. Notably, in pharmacology, they serve as valuable platforms for drug and vaccine delivery, facilitating the transport of active ingredients through various routes such as transdermal, oral, and parenteral...
February 21, 2024: Recent advances in drug delivery and formulation
https://read.qxmd.com/read/38385485/transfersomes-recent-advances-mechanisms-exhaustive-applications-clinical-trials-and-patents
#40
JOURNAL ARTICLE
Deeksha Manchanda, Manish Makhija, Parijat Pandey, Manu Sharma
A feasible nano transdermal delivery system generally intends to have specific ideal and distinct characteristics primarily for safety, clinical efficacy, and boosted therapeutic index. The delivery of drugs, particularly macromolecules, across the skin is one of the most strenuous obstacles in front of pharmaceutical scientists. Technology advancement has provided some opportunities to overcome this difficulty by utilising microneedle arrays, ablation, laser methods etc. However, associated uneasiness, painful sensation, and higher cost of therapies limit their day-to-day use...
February 21, 2024: Current Drug Delivery
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