keyword
MENU ▼
Read by QxMD icon Read
search

transdermal delivery system

keyword
https://www.readbyqxmd.com/read/28338352/formulation-challenges-for-21st-century-topical-and-transdermal-delivery-systems
#1
Mayank Singhal, Maria Lapteva, Yogeshvar N Kalia
No abstract text is available yet for this article.
March 24, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28338008/noninvasive-measurement-of-transdermal-drug-delivery-by-impedance-spectroscopy
#2
Pasquale Arpaia, Umberto Cesaro, Nicola Moccaldi
The effectiveness in transdermal delivery of skin permeation strategies (e.g., chemical enhancers, vesicular carrier systems, sonophoresis, iontophoresis, and electroporation) is poorly investigated outside of laboratory. In therapeutic application, the lack of recognized techniques for measuring the actually-released drug affects the scientific concept itself of dosage for topically- and transdermally-delivered drugs. Here we prove the suitability of impedance measurement for assessing the amount of drug penetrated into the skin after transdermal delivery...
March 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28330736/hyperspectral-imaging-using-near-infrared-spectroscopy-to-monitor-coat-thickness-uniformity-in-the-manufacture-of-a-transdermal-drug-delivery-system
#3
Naresh Pavurala, Xiaoming Xu, Yellela S R Krishnaiah
Hyperspectral imaging using near infrared spectroscopy (NIRS) integrates spectroscopy and conventional imaging to obtain both spectral and spatial information of materials. The non-invasive and rapid nature of hyperspectral imaging using NIRS makes it a valuable process analytical technology (PAT) tool for in-process monitoring and control of the manufacturing process for transdermal drug delivery systems (TDS). The focus of this investigation was to develop and validate the use of Near Infra-red (NIR) hyperspectral imaging to monitor coat thickness uniformity, a critical quality attribute (CQA) for TDS...
March 19, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28292673/bioresponsive-transcutaneous-patches
#4
REVIEW
Jicheng Yu, Yuqi Zhang, Anna R Kahkoska, Zhen Gu
Transdermal drug delivery systems that utilize transcutaneous patches of arrayed microneedles have attracted increasing interest in medical practice as an alternative method to hypodermic injection. Over the past ten years, research has focused on leveraging physiological signals associated with diseases or skin-specific tissues to create bioresponsive patches that release drug directly in response to an internally-generated stimulus. This review surveys the recent advances in the development and use of bioresponsive transcutaneous patches for on-demand smart and precise drug delivery, exploiting different physiological signals including pH, serum glucose levels, and enzyme activity...
March 11, 2017: Current Opinion in Biotechnology
https://www.readbyqxmd.com/read/28275153/an-oral-microjet-vaccination-system-elicits-antibody-production-in-rabbits
#5
Kiana Aran, Marc Chooljian, Jacobo Paredes, Mohammad Rafi, Kunwoo Lee, Allison Y Kim, Jeanny An, Jennifer F Yau, Helen Chum, Irina Conboy, Niren Murthy, Dorian Liepmann
Noninvasive immunization technologies have the potential to revolutionize global health by providing easy-to-administer vaccines at low cost, enabling mass immunizations during pandemics. Existing technologies such as transdermal microneedles are costly, deliver drugs slowly, and cannot generate mucosal immunity, which is important for optimal immunity against pathogens. We present a needle-free microjet immunization device termed MucoJet, which is a three-dimensional microelectromechanical systems-based drug delivery technology...
March 8, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28274741/a-systemic-evaluation-of-drug-in-acrylic-pressure-sensitive-adhesive-patch-in-vitro-and-in-vivo-the-roles-of-intermolecular-interaction-and-adhesive-mobility-variation-in-drug-controlled-release
#6
Chao Liu, Peng Quan, Shanshan Li, Yongshan Zhao, Liang Fang
Though acrylic pressure sensitive adhesives (PSAs) are widely used in transdermal drug delivery system, molecular details of drug-PSA interactions, PSA molecular mobility variations and their influences on drug skin permeation are unclear. In this study, three classes of acrylic PSAs containing hydroxyl (AAOH), carboxyl (AACOOH) and non-functional group (AAnone) were synthesized. Their abilities of controlling drug release were evaluated using propranolol (PRO) and zaltoprofen (ZAL) in vitro and in vivo. Interaction details were identified by FT-IR, solid-state NMR and molecular modeling...
March 6, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28252121/transdermal-cellular-membrane-penetration-of-proteins-with-gold-nanoparticles-a-molecular-dynamics-study
#7
Rakesh Gupta, Nishi Kashyap, Beena Rai
Transdermal delivery, where the skin acts as the route for local or systemic distribution, presents a lot of advantages over conventional routes such as oral and intravenous and intramuscular injections. However, the delivery of large biomolecules like proteins through the skin is challenging due to their size and structural properties. A molecular level understanding of their transport across the skin barrier is desirable to design successful formulations. We have employed constrained and unconstrained coarse grained molecular dynamics simulation techniques to obtain the molecular mechanism of penetration of the horseradish peroxidase (HRP) protein into the skin, in the presence and absence of gold nanoparticles (AuNPs)...
March 2, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28250103/the-nematocyst-s-sting-is-driven-by-the-tubule-moving-front
#8
Sinwook Park, Gadi Piriatinskiy, Dan Zeevi, Jonathan Ben-David, Gilad Yossifon, Uri Shavit, Tamar Lotan
The nematocyst is the explosive injection system of the phylum Cnidaria, and is one of the fastest delivery systems found in Nature. Exploring its injection mechanism is key for understanding predator-prey interactions and protection against jellyfish stinging. Here we analyse the injection of jellyfish nematocysts and ask how the build-up of the poly-γ-glutamate (pγGlu) osmotic potential inside the nematocyst drives its discharge. To control the osmotic potential, we used a two-channel microfluidic system to direct the elongating nematocyst tubule through oil, where no osmotic potential can develop, while keeping the nematocyst capsule in water at all times...
March 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/28243062/oral-and-transdermal-drug-delivery-systems-role-of-lipid-based-lyotropic-liquid-crystals
#9
REVIEW
Rajan Rajabalaya, Muhammad Nuh Musa, Nurolaini Kifli, Sheba R David
Liquid crystal (LC) dosage forms, particularly those using lipid-based lyotropic LCs (LLCs), have generated considerable interest as potential drug delivery systems. LCs have the physical properties of liquids but retain some of the structural characteristics of crystalline solids. They are compatible with hydrophobic and hydrophilic compounds of many different classes and can protect even biologicals and nucleic acids from degradation. This review, focused on research conducted over the past 5 years, discusses the structural evaluation of LCs and their effects in drug formulations...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28240177/formulation-of-niosomal-gel-for-enhanced-transdermal-lornoxicam-delivery-in-vitro-and-in-vivo-evaluation
#10
Mohamed Shafik El-Ridy, Soad Aly Yehia, Amira Mohamed Mohsen, Sally A El-Awdan, Asmaa Badawy Darwish
The objective of this study was to investigate the potential of niosomal gels as a transdermal delivery system to improve the permeation and anti-inflammatory activity of Lornoxicam (LX). LX niosomes were prepared by thin film hydration technique and were characterized using Transmission Electron Microscopy (TEM), Differential Scanning Calorimetry (DSC), Particle Size analysis and Zeta potential determination. LX niosomal gel/ LX loaded gel were prepared using Carbopol 934 (2%) and were evaluated for their physical appearance, pH and rheological behaviour...
February 24, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28228077/antioxidant-nanoplatforms-for-dermal-delivery-melatonin
#11
Aroha Belen Sánchez Milán, Ana C Calpena Campmany, Beatriz Clares Naveros
Melatonin (MLT) is emerging as a promising therapeutic agent, mainly due to its role as antioxidant. Substantial evidences show that melatonin is potentially effective on a variety of diseases as cancer, inflammation and neurodegenerative diseases. The excellent antioxidant capacity with pharmacokinetics characteristics and the emerging search for new pharmaceutical nanotechnology based systems, make it particularly attractive to elaborate nanoplatforms based on MLT for biomedical or cosmetic dermal applications...
February 22, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28228076/transdermal-drug-delivery-opportunities-and-challenges-for-controlled-delivery-of-therapeutic-agents-using-nanocarriers
#12
Balak Das Kurmi, Pawan Tekchandani, Rishi Paliwal, Shivani Rai Paliwal
BACKGROUND: Transdermal drug delivery represents an extremely attractive and innovative route across the skin owing to the possibility for achieving systemic effect of drugs. Present scenario demands a special focus on developing safe medicine with minimize toxic adverse effects related to most of the pharmacologically active agents. Transdermal drug delivery would be a focal paradigm which provides patient convenience, first-pass hepatic metabolism avoidance, local targeting and reduction in toxic effect related to various categories of drugs like, analgesics, anti-inflammatory, antibiotics, antiviral, anaesthetic, anticancer etc...
February 22, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28222612/in-vitro-ex-vivo-correlations-between-a-cell-laden-hydrogel-and-mucosal-tissue-for-screening-composite-delivery-systems
#13
Anna K Blakney, Adam B Little, Yonghou Jiang, Kim A Woodrow
Composite delivery systems where drugs are electrospun in different layers and vary the drug stacking-order are posited to affect bioavailability. We evaluated how the formulation characteristics of both burst- and sustained-release electrospun fibers containing three physicochemically diverse drugs: dapivirine (DPV), maraviroc (MVC) and tenofovir (TFV) affect in vitro and ex vivo release. We developed a poly(hydroxyethyl methacrylate) (pHEMA) hydrogel release platform for the rapid, inexpensive in vitro evaluation of burst- and sustained-release topical or dermal drug delivery systems with varying microarchitecture...
November 2016: Drug Delivery
https://www.readbyqxmd.com/read/28216463/successful-application-of-large-microneedle-patches-by-human-volunteers
#14
Anastasia Ripolin, James Quinn, Eneko Larrañeta, Eva Maria Vicente-Perez, Johanne Barry, Ryan F Donnelly
We describe, for the first time, the design, production and evaluation of large microneedle patches. Such systems, based on 16 individual microneedle arrays (needle height 600μm), were prepared from aqueous blends of 15% w/w Gantrez(®) S97 and 7.5% w/w poly(ethyleneglycol) 10,000Da. Ester-based crosslinking was confirmed by FTIR and mechanical strength was good. Insertion depths in a validated skin model were approximately 500μm. Ten human volunteers successfully self-inserted the microneedles of these larger patches in their skin, following appropriate instruction, as confirmed by transepidermal water loss measurements...
February 16, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28194704/challenges-and-future-prospects-for-the-delivery-of-biologics-oral-mucosal-pulmonary-and-transdermal-routes
#15
Javier O Morales, Kristin R Fathe, Ashlee Brunaugh, Silvia Ferrati, Song Li, Miguel Montenegro-Nicolini, Zeynab Mousavikhamene, Jason T McConville, Mark R Prausnitz, Hugh D C Smyth
Biologic products are large molecules such as proteins, peptides, nucleic acids, etc., which have already produced many new drugs for clinical use in the last decades. Due to the inherent challenges faced by biologics after oral administration (e.g., acidic stomach pH, digestive enzymes, and limited permeation through the gastrointestinal tract), several alternative routes of administration have been investigated to enable sufficient drug absorption into systemic circulation. This review describes the buccal, sublingual, pulmonary, and transdermal routes of administration for biologics with relevant details of the respective barriers...
February 13, 2017: AAPS Journal
https://www.readbyqxmd.com/read/28181840/transdermal-delivery-of-isoniazid-and-rifampin-in-guinea-pigs-by-electro-phonophoresis
#16
Suting Chen, Yi Han, Daping Yu, Fengmin Huo, Fen Wang, Yunxu Li, Lingling Dong, Zhidong Liu, Hairong Huang
Electro-phonophoresis (EP) has been used as a drug delivery approach in clinical fields. The objective of the present study is to evaluate the skin permeability of isoniazid and rifampin in guinea pigs by EP to provide reference basis for clinical applications of such transdermal delivery system in the treatment of patients with superficial tuberculosis. Isoniazid and rifampin solutions were delivered transdermally with or without EP in health guinea pigs for 0.5 h. Local skin and blood samples were collected serially at 0, 1/2, 1, 2, 4, 6 and 24 h after dosing...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28168430/poly-lactic-co-glycolic-acid-drug-delivery-systems-through-transdermal-pathway-an-overview
#17
REVIEW
Lucas Naves, Chetna Dhand, Luis Almeida, Lakshminarayanan Rajamani, Seeram Ramakrishna, Graça Soares
In past few decades, scientists have made tremendous advancement in the field of drug delivery systems (DDS), through transdermal pathway, as the skin represents a ready and large surface area for delivering drugs. Efforts are in progress to design efficient transdermal DDS that support sustained drug release at the targeted area for longer duration in the recommended therapeutic window without producing side-effects. Poly(lactic-co-glycolic acid) (PLGA) is one of the most promising Food and Drug Administration approved synthetic polymers in designing versatile drug delivery carriers for different drug administration routes, including transdermal drug delivery...
February 6, 2017: Progress in biomaterials
https://www.readbyqxmd.com/read/28163134/development-of-a-predictive-model-for-the-stabilizer-concentration-estimation-in-microreservoir-transdermal-drug-delivery-systems-mtdds-using-lipophilic-pressure-sensitive-adhesives-as-matrix-carrier
#18
Clémence Chenevas-Paule, Hans-Michael Wolff, Mark Ashton, Martin Schubert, Kalliopi Dodou
Microreservoir-type transdermal drug delivery systems (MTDDS) can prevent drug crystallization; however no current predictive model considers the impact of drug load and hydration on their physical stability. We investigated MTDDS films containing polyvinylpyrrolidone (PVP) as polymeric drug stabilizer in lipophilic pressure sensitive adhesive (silicone). Medicated and unmedicated silicone films with different molar N-vinylpyrrolidone (VP):drug ratios were prepared and characterized by FTIR, differential scanning calorimetry (DSC), scanning electron microscopy (SEM), microscopy, Dynamic Vapour Sorption (DVS) and stability testing for four months at different storage conditions...
February 2, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28160257/exploring-unsaturated-fatty-acid-cholesteryl-esters-as-transdermal-permeation-enhancers
#19
Sanjeev Rambharose, Rahul S Kalhapure, Mahantesh Jadhav, Thirumala Govender
The intrinsic protective barrier property of skin, one of the major challenges in the design of transdermal drug delivery systems, can be overcome through the use of chemical permeation enhancers (CPEs). Herein, we explore the potential of unsaturated fatty acid (UFA) esters of cholesterol (Chol) viz., oleate, linoleate and linolenate, as transdermal CPEs using tenofovir (TNF) as a model drug. All Chol UFA esters at 1% w/w were found to be more effective enhancers when compared to their respective parent fatty acids (FAs) and saturated FA counterparts...
April 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28159724/rationalising-polymer-selection-for-supersaturated-film-forming-systems-produced-by-an-aerosol-spray-for-the-transdermal-delivery-of-methylphenidate
#20
A Edwards, S Qi, F Liu, M B Brown, W J McAuley
Film forming systems offer a number of advantages for topical and transdermal drug delivery, in particular enabling production of a supersaturated state which can greatly improve drug absorption and bioavailability. However the suitability of individual film forming polymers to stabilise the supersaturated state and optimise delivery of drugs is not well understood. This study reports the use of differential scanning calorimetry (DSC) to measure the solubility of methylphenidate both as the free base and as the hydrochloride salt in two polymethacrylate copolymers, Eudragit RS (EuRS) and Eudragit E (EuE) and relates this to the ability of films formed using these polymers to deliver methylphenidate across a model membrane...
January 31, 2017: European Journal of Pharmaceutics and Biopharmaceutics
keyword
keyword
53892
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"