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transdermal delivery system

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https://www.readbyqxmd.com/read/28722543/comparison-of-ovalbumin-and-ovalbumin-epitope-peptide-for-transdermal-delivery-and-vaccination-mediated-by-the-photothermal-effect-of-gold-nanorods
#1
Aung Thu Haine, Yuji Miyamoto, Taishi Higashi, Keiichi Motoyama, Hidetoshi Arima, Takuro Niidome
Transdermal protein delivery is a powerful and attractive method for protein therapy and dermal vaccination compared with other administrations. However, this delivery method is restricted by the low permeability of the stratum corneum, a hydrophobic barrier that restricts the entry of hydrophilic molecules such as proteins. In this study, we developed an improved gel patch system carrying ovalbumin and ovalbumin epitope peptide, and then compared their permeability into the skin. First, the gel patch was placed on mouse skin to allow contact with the polymer coated gold nanorods and then irradiated by a continuous-wave laser...
July 19, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28721013/a-novel-local-anesthetic-system-transcriptional-transactivator-peptide-decorated-nanocarriers-for-skin-delivery-of-ropivacaine
#2
Chuanyu Chen, Peijun You
PURPOSE: Barrier properties of the skin and physicochemical properties of drugs are the main factors for the delivery of local anesthetic molecules. The present work evaluates the anesthetic efficacy of drug-loaded nanocarrier (NC) systems for the delivery of local anesthetic drug, ropivacaine (RVC). METHODS: In this study, transcriptional transactivator peptide (TAT)-decorated RVC-loaded NCs (TAT-RVC/NCs) were successfully fabricated. Physicochemical properties of NCs were determined in terms of particle size, zeta potential, drug encapsulation efficiency, drug-loading capacity, stability, and in vitro drug release...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28711712/ex-vivo-and-in-vivo-evaluation-of-microemulsion-based-transdermal-delivery-of-e-coli-specific-t4-bacteriophage-a-rationale-approach-to-treat-bacterial-infection
#3
Vaibhav Rastogi, Pragya Yadav, Anurag Verma, Jayanta K Pandit
This study is focused on the development and evaluation of transdermal delivery of E. coli-specific T4 bacteriophages both ex-vivo and in-vivo using microemulsion as delivery carrier in eradicating the infection caused by E. coli. Microemulsions were prepared by mixing selected oil, surfactants and aqueous phase containing bacteriophages. The formulations were subjected to physicochemical characterization, ex-vivo and in-vivo permeation, stability studies, histological and immunofluorescence examination. The colloidal system exhibits a uniform size distribution, of finite size (150-320nm)...
July 12, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28711550/chitosan-whisker-grafted-with-oligo-lactic-acid-nanoparticles-via-a-green-synthesis-pathway-potential-as-a-transdermal-drug-delivery-system
#4
Visuta Engkagul, I-Yanut Klaharn, Amornpun Sereemaspun, Suwabun Chirachanchai
Chitosan whisker (CSWK) grafted with oligo(lactic acid) (OLA) nanoparticles (NPs) in water is developed to aid transferring therapeutic agents through the skin in a transdermal drug delivery system. Although several works in the past have shown grafting of poly(lactic acid) onto chitosan, the present work shows a green grafting system for the first time. The nano-sized CSWK provided effective conjugation of lactic acid even in a heterogeneous water-based system followed by polycondensation to form OLA. The OLA chain length is controlled by the lactic acid content and modulates the lipophilicity of CSWK-OLA...
July 13, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28709973/fractional-derivatives-in-the-diffusion-process-in-heterogeneous-systems-the-case-of-transdermal-patches
#5
Michele Caputo, Cesare Cametti
In this note, we present a simple mathematical model of drug delivery through transdermal patches by introducing a memory formalism in the classical Fick diffusion equation based on the fractional derivative. This approach is developed in the case of a medicated adhesive patch placed on the skin to deliver a time released dose of medication through the skin towards the bloodstream.The main resistance to drug transport across the skin resides in the diffusion through its outermost layer (the stratum corneum)...
July 11, 2017: Mathematical Biosciences
https://www.readbyqxmd.com/read/28706327/current-advances-in-transdermal-delivery-of-drugs-for-alzheimer-s-disease
#6
REVIEW
Thuy Trang Nguyen, Vo Van Giau, Tuong Kha Vo
Alzheimer's disease (AD) is a common, progressive, fatal neurodegenerative disorder, which will play an increasingly important role both socially and financially in the aging populations. Treatments for AD show modest improvements in cognition and global functioning among patients. Furthermore, the oral administration of treating AD has had some drawbacks that decrease the medication adherence and efficacy of the therapy. Transdermal drugs are proposed as an alternative remedy to overcome the disadvantages of current pharmaceutical dosage options for this chronic disorder...
March 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/28693956/mechanistic-insights-of-the-enhancement-effect-of-sorbitan-monooleate-on-olanzapine-transdermal-patch-both-in-release-and-percutaneous-absorption-processes
#7
Ning Li, Peng Quan, XiaoCao Wan, Chao Liu, Xiaochang Liu, Liang Fang
In this paper, based on the optimized formulation of olanzapine (OLN) transdermal patch, the role of sorbitan monooleate (SP) in OLN release and percutaneous absorption processes was probed in vitro and in vivo. Rheological test, DSC, FT-IR and molecular modeling were conducted to elucidate the effect of SP on the release process of OLN from transdermal patch. Additionally, the action of SP on the percutaneous absorption process was probed using tape stripping transdermal experiment, confocal laser scanning microscopy (CLSM), ATR-FTIR and molecular docking...
July 8, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28682286/analgesic-efficacy-and-safety-of-transdermal-and-oral-diclofenac-in-postoperative-pain-management-following-dental-implant-placement
#8
S Raja Rajeswari, Triveni Gowda, Tarun Kumar, Dhoom S Mehta, Kanchan Arya
The aim of this study was to compare the efficacy and safety of transdermal and oral routes of diclofenac for postoperative pain management in patients undergoing dental implant placement. Twenty systemically healthy, partially edentulous patients who required dental implants bilaterally in the mandibular first molar region were included. While the patient was under local anesthesia, an implant was placed in the mandibular first molar region of one quadrant. After a minimum of 4 weeks, an implant was placed in the contralateral quadrant under local anesthesia...
July 2017: General Dentistry
https://www.readbyqxmd.com/read/28670109/controlled-release-of-optimized-electroporation-enhances-the-transdermal-efficiency-of-sinomenine-hydrochloride-for-treating-arthritis-in-vitro-and-in-clinic
#9
Shun Feng, Lijun Zhu, Zhisheng Huang, Haojia Wang, Hong Li, Hua Zhou, Linlin Lu, Ying Wang, Zhongqiu Liu, Liang Liu
Sinomenine hydrochloride (SH) is an ideal drug for the treatment of rheumatoid arthritis and osteoarthritis. However, high plasma concentration of systemically administered SH can release histamine, which can cause rash and gastrointestinal side effects. Topical delivery can increase SH concentration in the synovial fluid without high plasma level, thus minimizing systemic side effects. However, passive diffusion of SH was found to be inefficient because of the presence of the stratum corneum layer. Therefore, an effective method is required to compensate for the low efficiency of SH passive diffusion...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28660400/development-of-a-two-dimensional-model-for-predicting-transdermal-permeation-with-the-follicular-pathway-demonstration-with-a-caffeine-study
#10
Panayiotis Kattou, Guoping Lian, Stephen Glavin, Ian Sorrell, Tao Chen
PURPOSE: The development of a new two-dimensional (2D) model to predict follicular permeation, with integration into a recently reported multi-scale model of transdermal permeation is presented. METHODS: The follicular pathway is modelled by diffusion in sebum. The mass transfer and partition properties of solutes in lipid, corneocytes, viable dermis, dermis and systemic circulation are calculated as reported previously [Pharm Res 33 (2016) 1602]. The mass transfer and partition properties in sebum are collected from existing literature...
June 28, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28655324/the-topical-application-of-low-temperature-argon-plasma-enhances-the-anti-inflammatory-effect-of-jaun-ointment-on-dncb-induced-nc-nga-mice
#11
Jeong-Hae Choi, Yeon-Suk Song, Hae-June Lee, Gyoo-Cheon Kim, Jin-Woo Hong
BACKGROUND: Jaun-ointment (JO), also known as Shiunko in Japan, is one of the most popular medicinal formulae used in Korean traditional medicine for the external treatment of skin wound and inflammatory skin conditions. Since JO is composed of crude mixture of two herbal extracts (radix of Lithospermum erythrorhizon Siebold & Zucc and Angelica gigas Nakai), those been proved its anti-inflammatory activities in-vitro and in-vivo, JO has been expected as a good alternative treatment option for atopic dermatitis (AD)...
June 27, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28631206/diclofenac-loaded-lipid-nanovesicles-prepared-by-double-solvent-displacement-for-skin-drug-delivery
#12
M Sala, F Locher, M Bonvallet, G Agusti, A Elaissari, H Fessi
PURPOSE: Herein, we detail a promising strategy of nanovesicle preparation based on control of phospholipid self-assembly: the Double Solvent Displacement. A systematic study was conducted and diclofenac as drug model encapsulated. In vitro skin studies were carried out to identify better formulation for dermal/transdermal delivery. METHODS: This method consists in two solvent displacements. The first one, made in a free water environment, has allowed triggering a phospholipid pre-organization...
June 19, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28620730/advances-towards-painless-vaccination-and-newer-modes-of-vaccine-delivery
#13
Neha Garg, Anju Aggarwal
Vaccines have been successful in reducing the mortality and morbidity, but most of them are delivered by intramuscular or intravenous route. They are associated with pain to the baby and bring lot of anxiety for the parents. There has been a marked increase in the number of injections required in first two years of life for completing the vaccination schedule. Hence, there is a need to have a painless vaccine delivery system. Numerous new routes of vaccination like, oral, nasal and transdermal routes are being tried...
June 16, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28610893/an-insight-into-the-molecular-mechanism-of-the-temporary-enhancement-effect-of-isopulegol-decanoate-on-the-skin
#14
Xiaochang Liu, Meiying Liu, Chao Liu, Peng Quan, Yongshan Zhao, Liang Fang
Chemical enhancers are widely used to facilitate drug permeation in transdermal drug delivery system (TDDS) and the effect of chemical enhancers is desired to be temporary. Though temporary enhancement effect of chemical enhancers has been widely discussed, there is still a lack of knowledge about the molecular mechanism of temporary enhancement effect. Using the skin permeation of flurbiprofen as a probe, the temporary enhancement effect of isopulegol decanoate (ISO-10) was evaluated with in vitro permeation experiment and confocal laser scanning microscopy (CLSM)...
June 10, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28608140/on-the-road-to-development-of-an-in-vitro-permeation-test-ivpt-model-to-compare-heat-effects-on-transdermal-delivery-systems-exploratory-studies-with-nicotine-and-fentanyl
#15
Soo Hyeon Shin, Priyanka Ghosh, Bryan Newman, Dana C Hammell, Sam G Raney, Hazem E Hassan, Audra L Stinchcomb
PURPOSE: At elevated temperatures, the rate of drug release and skin permeation from transdermal delivery systems (TDS) may be higher than at a normal skin temperature. The aim of this study was to compare the effect of heat on the transdermal delivery of two model drugs, nicotine and fentanyl, from matrix-type TDSs with different formulations, using in vitro permeation tests (IVPT). METHODS: IVPT experiments using pig skin were performed on two nicotine and three fentanyl TDSs...
June 12, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28600224/enhancement-of-transdermal-protein-delivery-by-photothermal-effect-of-gold-nanorods-coated-on-polysaccharide-based-hydrogel
#16
Aung Thu Haine, Yuki Koga, Yuta Hashimoto, Taishi Higashi, Keiichi Motoyama, Hidetoshi Arima, Takuro Niidome
Transdermal protein delivery is a useful and attractive method for protein therapy and dermal vaccination. However, this delivery method is restricted by the low permeability of the stratum corneum. The purpose of this study was to develop a transdermal delivery system for enhancement of protein permeability into the skin. First, we prepared a transparent gel patch made of polysaccharides with gold nanorods on the gel surface and fluorescein isothiocyanate-modified ovalbumin (FITC-OVA) inside. Next, the gel patch was placed on mouse skin to allow contact with the coated gold nanorods, and irradiated by a continuous-wave laser...
June 6, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28576549/computational-and-experimental-model-of-transdermal-iontophorethic-drug-delivery-system
#17
Nenad Filipovic, Igor Saveljic, Vladislav Rac, Beatriz Olalde Graells, Goran Bijelic
The concept of iontophoresis is often applied to increase the transdermal transport of drugs and other bioactive agents into the skin or other tissues. It is a non-invasive drug delivery method which involves electromigration and electroosmosis in addition to diffusion and is shown to be a viable alternative to conventional administration routs such as oral, hypodermic and intravenous injection. In this study we investigated, experimentally and numerically, in vitro drug delivery of dexamethasone sodium phosphate to porcine skin...
May 31, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28574158/efficacy-and-safety-of-a-new-microneedle-patch-for-skin-brightening-a-randomized-split-face-single-blind-study
#18
Kui Young Park, Hyun Jung Kwon, Changjin Lee, Daegun Kim, Jun Jin Yoon, Myeong Nam Kim, Beom Joon Kim
BACKGROUND: Although microneedles are one of the best transdermal drug delivery systems for active compounds, few clinical trials have examined the safety and efficacy of brightening microneedle patches. AIMS: To determine the efficacy and safety of a newly developed whitening microneedle patch. PATIENTS/METHODS: A split-face study was designed for efficacy assessment with 34 Korean women applying the tested product (a whitening microneedle patch) on one cheek and a control whitening essence on the other...
June 2, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28571549/nanoemulsion-based-transdermal-drug-delivery-system-for-the-treatment-of-tuberculosis
#19
Mohammad Wais, Mohd Aqil, Ashish Kumar Sharma, Jaya Agnihotri
BACKGROUND: The nanoemulsion based carriers are the most suitable delivery systems for poorly soluble drugs to improve the solubility of drugs, permeation of drugs and ultimately increase bioavailability by transdermal therapeutic system. The nanoemulsion for poorly soluble drugs is the excellent and offered several advantages over others carriers. METHODS: For the nanoemulsions formulation they have to deliver the energetic element at the specific organ with nominal uneasiness...
June 1, 2017: Recent Patents on Anti-infective Drug Discovery
https://www.readbyqxmd.com/read/28546106/enhanced-dissolution-and-skin-permeation-profiles-of-epalrestat-with-%C3%AE-cyclodextrin-derivatives-using-a-cogrinding-method
#20
Takayuki Furuishi, Shoma Takahashi, Noriko Ogawa, Mihoko Gunji, Hiromasa Nagase, Toyofumi Suzuki, Tomohiro Endo, Haruhisa Ueda, Etsuo Yonemochi, Kazuo Tomono
Epalrestat (EPL) is a water-insoluble drug (14μM) that inhibits aldose reductase. This study investigated the interactions between β-cyclodextrin (CD) derivatives and EPL to determine the solubilizing effect on EPL from phase solubility diagrams. We improved the solubility of EPL in water by adding β-CD derivatives. Moreover, the solubility of EPL mixed with β-CD derivatives by cogrinding in a ball mill method was about 2-3 times higher than those of EPL with the same CD concentration (5mM) calculated from phase solubility diagrams...
August 30, 2017: European Journal of Pharmaceutical Sciences
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