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transdermal delivery system

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https://www.readbyqxmd.com/read/28494734/recent-advances-in-skin-penetration-enhancers-for-transdermal-gene-and-drug-delivery
#1
Morteza Amjadi, Babak Mostaghaci, Metin Sitti
There is a growing interest in transdermal delivery systems because of their noninvasive, targeted, and on-demand delivery of gene and drugs. However, efficient penetration of therapeutic compounds into the skin is still challenging largely due to the impermeability of the outermost layer of the skin, known as stratum corneum. Recently, there have been major research activities to enhance the skin penetration depth of pharmacological agents. This article reviews recent advances in the development of various strategies for skin penetration enhancement...
May 10, 2017: Current Gene Therapy
https://www.readbyqxmd.com/read/28493100/characterization-of-temperature-profiles-in-skin-and-transdermal-delivery-system-when-exposed-to-temperature-gradients-in-vivo-and-in-vitro
#2
Qian Zhang, Michael Murawsky, Terri LaCount, Jinsong Hao, Gerald B Kasting, Bryan Newman, Priyanka Ghosh, Sam G Raney, S Kevin Li
PURPOSE: Performance of a transdermal delivery system (TDS) can be affected by exposure to elevated temperature, which can lead to unintended safety issues. This study investigated TDS and skin temperatures and their relationship in vivo, characterized the effective thermal resistance of skin, and identified the in vitro diffusion cell conditions that would correlate with in vivo observations. METHODS: Experiments were performed in humans and in Franz diffusion cells with human cadaver skin to record skin and TDS temperatures at room temperature and with exposure to a heat flux...
May 10, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28486181/anti-tumor-efficacy-of-an-integrated-methyl-dihydrojasmonate-transdermal-microemulsion-system-targeting-breast-cancer-cells-in-vitro-and-in-vivo-studies
#3
Rania Yehia, Rania M Hathout, Dalia A Attia, Mohamed M Elmazar, Nahed D Mortada
Targeting solid tumors transdermally is an emerging approach that is currently under intense investigation. In this context, microemulsions are reported as one of the most favored carriers for successful transdermal drug delivery. Thereby, these nano-carriers were utilized in this study for the delivery of a phytochemical, namely methyl dihydrojasmonate (MDHJ), which has previously demonstrated an anticancer effect. Accordingly, pseudoternary phase diagrams were constructed using several combinations of oils, surfactants and co-surfactants and following the water titration method...
April 23, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28482667/granisetron-transdermal-delivery-system-is-effective-in-the-control-of-chemotherapy-induced-nausea-and-vomiting-in-patients-receiving-moderately-emetogenic-chemotherapy-mec-or-highly-emetogenic-chemotherapy-hec-in-china
#4
https://www.readbyqxmd.com/read/28482575/risedronate-transdermal-delivery-system-based-on-a-fumaric-copolymer-for-therapy-of-osteoporosis
#5
Magalí Pasqualone, Héctor A Andreetta, M Susana Cortizo
Transdermal drug delivery system (TDDS) could be seen as alternative to the oral administration which avoids several adverse effects. In this study a novel TDDS for risedronate (RI), a bisphosphonate used for osteoporosis treatment, based on a vinyl acetate-dioctylfumarate copolymer, poly(VA-co-DOF), previously synthetized, was developed. Two membranes including 6 and 12% (w/w) of drug were obtained, which exhibited good transparence and homogeneous drug distribution, as evaluated by optical microscopy. FTIR spectroscopy and differential scanning calorimetry (DSC) analysis showed no significant drug/polymer interactions, only a plasticizer effect...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28482547/development-and-in-vitro-evaluation-of-potential-electromodulated-transdermal-drug-delivery-systems-based-on-carbon-nanotube-buckypapers
#6
Alex Schwengber, Héctor J Prado, Pablo R Bonelli, Ana L Cukierman
Buckypapers based on different types of carbon nanotubes with and without the addition of four model drugs, two of basic nature (clonidine hydrochloride, selegiline hydrochloride) and the others of acidic character (flurbiprofen, ketorolac tromethamine) were prepared and characterized. The influence of the conditions employed in the preparation of the buckypapers (dispersion time and solvents used in the preparation, as well as the type of carbon nanotubes used and the characteristics of the drug involved) on their conductivity was especially examined...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28480438/preparation-and-properties-of-compound-arnebiae-radix-microemulsion-gel
#7
Jing Chen, Yanping He, Ting Gao, Licheng Zhang, Yuna Zhao
BACKGROUND: Compound Arnebiae radix oil has been clinically applied to treat burns and scalds for a long time. However, it is unstable and inconvenient to use. The aim of this study was to prepare a compound Arnebiae radix microemulsion gel for transdermal delivery system and evaluate its characteristics. MATERIALS AND METHODS: Based on the solubility of Shikonin, the active component of Arnebiae radix and the results of phase studies, adequate ratio of each component in microemulsion was determined...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28480080/deformable-nanovesicles-synthesized-through-an-adaptable-microfluidic-platform-for-enhanced-localized-transdermal-drug-delivery
#8
Naren Subbiah, Jesus Campagna, Patricia Spilman, Mohammad Parvez Alam, Shivani Sharma, Akishige Hokugo, Ichiro Nishimura, Varghese John
Phospholipid-based deformable nanovesicles (DNVs) that have flexibility in shape offer an adaptable and facile method to encapsulate diverse classes of therapeutics and facilitate localized transdermal delivery while minimizing systemic exposure. Here we report the use of a microfluidic reactor for the synthesis of DNVs and show that alteration of input parameters such as flow speeds as well as molar and flow rate ratios increases entrapment efficiency of drugs and allows fine-tuning of DNV size, elasticity, and surface charge...
2017: Journal of Drug Delivery
https://www.readbyqxmd.com/read/28470586/advanced-analgesic-drug-delivery-and-nanobiotechnology
#9
REVIEW
Nicoleta Stoicea, Juan Fiorda-Diaz, Nicholas Joseph, Muhammad Shabsigh, Carlos Arias-Morales, Alicia A Gonzalez-Zacarias, Ana Mavarez-Martinez, Stephen Marjoribanks, Sergio D Bergese
Transdermal administration of analgesic medications offers several benefits over alternative routes of administration, including a decreased systemic drug load with fewer side effects, and avoidance of drug degradation by the gastrointestinal tract. Transdermal administration also offers a convenient mode of drug administration over an extended period of time, particularly desirable in pain medicine. A transdermal administration route may also offer increased safety for drugs with a narrow therapeutic window...
May 3, 2017: Drugs
https://www.readbyqxmd.com/read/28461268/formulation-and-characterisation-of-dissolving-microneedles-for-the-transdermal-delivery-of-therapeutic-peptides
#10
Colin Dillon, Helen Hughes, Niall J O'Reilly, Peter McLoughlin
The highly effective barrier properties of the stratum corneum (SC) limit the application of transdermal delivery to relatively small, lipophilic molecules. Microneedles (MNs) however, offer a route to effectively deliver a wide range of pharmaceuticals through the skin, bypassing the SC in a non-invasive and pain-free manner. This study presents a dissolving MN system composed of polyvinylpyrrolidone (PVP) and trehalose to encapsulate active pharmaceutical peptides within the MN matrix. Rapid systemic delivery is then achieved once the needles have penetrated the SC and dissolved in the interstitial fluid of the skin...
April 28, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28460145/from-immediate-release-to-long-acting-drug-delivery-systems-what-do-they-mean-and-why-do-they-matter
#11
Laura G Leahy
Understanding the varied delivery systems of today's medications can not only simplify dosing schedules but also improve medication adherence, reduce adverse events and polypharmacy, and increase patients' overall quality of life. Whether a medication is noted as immediate, controlled, delayed, or extended release can influence patient adherence as well as tolerability of the drug. New and novel delivery systems, such as long-acting weekly formulations or biweekly and monthly injectable agents, can offer steady blood levels of the drug, avoiding the daily fluctuations that may lead to side effects...
May 1, 2017: Journal of Psychosocial Nursing and Mental Health Services
https://www.readbyqxmd.com/read/28447799/enhanced-transdermal-delivery-by-combined-application-of-dissolving-microneedle-patch-on-serum-treated-skin
#12
Suyong Kim, Manita Dangol, Geonwoo Kang, Shayan F Lahiji, Huisuk Yang, Mingyu Jang, Yonghao Ma, Chengguo Li, Sang Gon Lee, Chang Hyun Kim, Young Wook Choi, So Jeong Kim, Ja Hyun Ryu, Ji Hwoon Baek, Jaesuk Koh, Hyungil Jung
Dissolving microneedle (DMN), a transdermal drug delivery system in which drugs are encapsulated in a biodegradable polymeric microstructure, is designed to dissolve after skin penetration and release the encapsulated drugs into the body. However, because of limited loading capacity of drugs within microsized structures, only a small dosage can be delivered, which is often insufficient for patients. We propose a novel DMN application that combines topical and DMN application simultaneously to improve skin permeation efficiency...
May 5, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28444555/evaluating-the-effectiveness-of-a-novel-atomized-liquid-needle-free-transdermal-delivery-system
#13
Yi-Huei Huang, Chieh-Shen Hu, Yi-Jhen Ke, Chiao-Hsi Chiang, Po-Da Hong, Ming-Kung Yeh
Needle-free jet injections constitute a crucial method for drug delivery. A novel liquid drug delivery system has been proposed recently, in which pressure atomizes liquid before delivering that atomized liquid to the patient's body; however, the mechanism and efficiency of the system are unclear. This study explored the shot delivery pressure, penetration depth, and cumulative amount of permeation of this system. This system was used to deliver 0.5% (w/v) methylene blue to agarose phantoms at various shot delivery pressures...
April 25, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28432615/fabrication-physicochemical-characterization-and-performance-evaluation-of-biodegradable-polymeric-microneedle-patch-system-for-enhanced-transcutaneous-flux-of-high-molecular-weight-therapeutics
#14
Viral Shah, Bijaya Krushna Choudhury
A revolutionary paradigm shift is being observed currently, towards the use of therapeutic biologics for disease management. The present research was focused on designing an efficient dosage form for transdermal delivery of α-choriogonadotropin (high molecular weight biologic), through biodegradable polymeric microneedles. Polyvinylpyrrolidone-based biodegradable microneedle arrays loaded with high molecular weight polypeptide, α-choriogonadotropin, were fabricated for its systemic delivery via transdermal route...
April 21, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28426265/transdermal-iontophoresis-patch-with-reverse-electrodialysis
#15
Joon Lee, Kilsung Kwon, Minyoung Kim, Joonhong Min, Nathaniel S Hwang, Won-Serk Kim
Reverse electrodialysis (RED) technology generates energy from the salinity gradient by contacting waters with different salinity. Herein, we develop the disposable skin patch using this eco-friendly energy. The current density, which can be controlled easily without special circuit, is enough to iontophoretic drug delivery. In vitro study, this iontophoretic system enhanced the transdermal delivery of peptide, which is difficult to penetrate the skin barrier by simple diffusion. We design the disposable iontophoretic skin patch using RED system and suggest this patch can be apply on new cosmetic patch or disposable drug patch...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28412398/recent-update-on-nanoemulgel-as-topical-drug-delivery-system
#16
REVIEW
Hira Choudhury, Bapi Gorain, Manisha Pandey, Lipika Alok Chatterjee, Pinaki Sengupta, Arindam Das, Nagashekhara Molugulu, Prashant Kesharwani
Being an emerging transdermal delivery tool, nanoemulgel, has proved to show surprising upshots for the lipophilic drugs over other formulations. This lipophilic nature of majority of the newer drugs developed in this modern era resulting in poor oral bioavailability, erratic absorption, and pharmacokinetic variations. Therefore, this novel transdermal delivery system has been proved to be advantageous over other oral and/or topical drug delivery to avoid such disturbances. These nanoemulgels are basically oil-in-water nanoemulsions gelled with the use of some gelling agent in it...
April 12, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28411333/technological-device-for-manufacturing-transdermal-films-possible-applications-to-the-individualized-treatment-for-erectile-dysfunction
#17
Francisco José Raposo, Hudson Caetano Polonini, Anderson Ferreira, Nádia Rezende Barbosa Raposo, Marcos Antônio Fernandes Brandão
Pharmacological advances in erectile dysfunction (ED) treatment have aroused growing interest among health professionals towards sexual dysfunction, generating an increasing demand for dosage forms and drug delivery systems, including tadalafil. This study aimed to develop a device to generate patches that would enable drug dosage individualization and transdermal administration. To create such a mechanical device, technical drawings were made using the CAD software. A functional prototype was built, and a pharmaceutical formulation containing tadalafil (10 mg cm(-2)) was prepared...
April 14, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28406442/liposomal-encapsulation-for-systemic-delivery-of-propranolol-via-transdermal-iontophoresis-improves-bone-microarchitecture-in-ovariectomized-rats
#18
Benjamin Teong, Shyh Ming Kuo, Wei-Hsin Tsai, Mei-Ling Ho, Chung-Hwan Chen, Han Hsiang Huang
The stimulatory effects of liposomal propranolol (PRP) on proliferation and differentiation of human osteoblastic cells suggested that the prepared liposomes-encapsulated PRP exerts anabolic effects on bone in vivo. Iontophoresis provides merits such as sustained release of drugs and circumvention of first pass metabolism. This study further investigated and evaluated the anti-osteoporotic effects of liposomal PRP in ovariectomized (OVX) rats via iontophoresis. Rats subjected to OVX were administered with pure or liposomal PRP via iontophoresis or subcutaneous injection twice a week for 12 weeks...
April 13, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28405912/continuous-transdermal-delivery-of-l-dopa-based-on-a-self-assembling-nanomicellar-system
#19
Amnon C Sintov, Haim V Levy, Igor Greenberg
PURPOSE: When levodopa (L-DOPA) is administered orally, it is eliminated from the body very quickly resulting in a series of sharp fluctuations in its blood concentrations. These frequent changes in blood levels are considered to be responsible for the development of late motor complications and dyskinesias, which are troubling clinical and treatment issues in Parkinson's disease. Transdermal drug delivery is a patient-compliant method for delivering therapeutics into the systemic circulation in a continuous and controlled manner...
April 12, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28405574/formulation-and-evaluation-of-transdermal-drug-delivery-of-topiramate
#20
Suneetha Cherukuri, Uma Rajeswari Batchu, Kiranmai Mandava, Vidhyullatha Cherukuri, Koteswara Rao Ganapuram
BACKGROUND: Transdermal drug delivery system (TDDS) was designed to sustain the release and improve the bioavailability of drug and patient compliance. Among the various types of transdermal patches, matrix dispersion type systems disperse the drug in the solvent along with the polymers and solvent is allowed to evaporate forming a homogeneous drug-polymer matrix. The objective of the present study was to design and formulate TDDS of topiramate (TPM) and to evaluate their extended release in vitro and ex vivo...
January 2017: International Journal of Pharmaceutical Investigation
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