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transdermal delivery system

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https://www.readbyqxmd.com/read/29771146/nanosized-ethanol-based-malleable-liposomes-of-cytarabine-to-accentuate-transdermal-delivery-formulation-optimization-in-vitro-skin-permeation-and-in-vivo-bioavailability
#1
Rakesh Raj, Pooja Mongia Raj, Alpana Ram
Cytarabine is a pyrimidine nucleoside analog used predominantly for acute myeloid leukemia (AML) and also for other indications, including acute lymphocytic leukemia, chronic myelogenous leukemia, and lymphoma by parenteral route due to its low oral bioavailability. Parenteral administration requires constant plasma level, monitoring for its fluctuation and poor patients compliances. Hence the objective of this work is to construct optimized nanosized malleable liposomes of cytarabine to accentuate transdermal delivery of drug to circumvent previously mentioned drawbacks...
May 17, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29740759/characterization-and-in-vitro-permeation-study-of-cubic-liquid-crystal-containing-sinomenine-hydrochloride
#2
Xiaoqin Chu, Qian Li, Shuangying Gui, Zhengguang Li, Jiaojiao Cao, Jianqin Jiang
This study developed a new transdermal delivery system for the improved delivery of sinomenine hydrochloride (SH). The delivery system utilized the advantages of lyotropic liquid crystals (LLC) creating an adaptable system that offers a variety of options for the field of transdermal delivery. The formulation was prepared, characterized, and evaluated for its skin penetration in vitro. In the study, the appearance of samples was characterized by visual observation, and these LLC gels were colorless and transparent...
May 8, 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29731664/perioperative-analgesia-with-a-buprenorphine-transdermal-patch-for-hallux-valgus-surgery-a-prospective-randomized-controlled-study
#3
Can Xu, Mingqing Li, Chenggong Wang, Hui Li, Hua Liu
Purpose: Hallux valgus surgery often results in significant postoperative pain. Adequate control of pain is essential for patient satisfaction and improves the outcome of the procedure. This study aimed to investigate the perioperative analgesic effect of a buprenorphine transdermal patch in patients who underwent hallux valgus surgery. Patients and methods: A total of 90 patients were randomly divided into the following three groups based on the perioperative analgesic method: flurbiprofen axetil intravenous injection (Group F), oral celecoxib (Group C), and buprenorphine transdermal delivery system (BTDS) (Group BTDS)...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29722421/carbon-nanotubes-cnts-based-advanced-dermal-therapeutics-current-trends-and-future-potential
#4
REVIEW
Kaushik Kuche, Rahul Maheshwari, Vishakha Tambe, Kit-Kay Mak, Hardi Jogi, Nidhi Raval, Mallikarjuna Rao Pichika, Rakesh Kumar Tekade
The search for effective and non-invasive delivery modules to transport therapeutic molecules across skin has led to the discovery of a number of nanocarriers (viz.: liposomes, ethosomes, dendrimers, etc.) in the last few decades. However, available literature suggests that these delivery modules face several issues including poor stability, low encapsulation efficiency, and scale-up hurdles. Recently, carbon nanotubes (CNTs) emerged as a versatile tool to deliver therapeutics across skin. Superior stability, high loading capacity, well-developed synthesis protocol as well as ease of scale-up are some of the reason for growing interest in CNTs...
May 3, 2018: Nanoscale
https://www.readbyqxmd.com/read/29716869/delivery-of-risperidone-from-gels-across-porcine-skin-in-vitro-and-in-vivo-in-rabbits
#5
Yuming Ning, Xiaojin Chen, Zhenwei Yu, Wenquan Liang, Fanzhu Li
The purpose of this study was to develop and evaluate a transdermal delivery system for RIS using hydrogels. First, the effects of different concentrations of hydroxypropyl methylcellulose and Carbomer 934 (CBR) on RIS permeation were investigated in porcine skin. The optimized formulation was chosen as the base gel to screen for penetration enhancers. The pharmacokinetics of the optimized RIS formulation was then studied in vitro in rabbits. A formulation with 0.5% CBR showed the highest RIS permeation and was selected as the base gel...
May 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29714143/cutaneous-application-of-celecoxib-for-inflammatory-and-cancer-diseases
#6
Oliesia Gonzales Quinones, Maria Bernadete Riemma Pierre
BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) and particularly selective cyclooxygenase-2 (COX-2) inhibitors such as celecoxib (Cxb) are considered promising cancer chemopreventive for colon, breast, prostate, lung, and skin cancers. However, the clinical application to the prevention is limited by concerns about safety, potential to serious toxicity (mainly for healthy individuals), efficacy and optimal treatment regimen. Cxb exhibits advantages as potent anti-inflammatory and gastrointestinal tolerance compared with conventional NSAID's...
April 30, 2018: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/29714001/dry-gel-containing-optimized-felodipine-loaded-transferosomes-a-promising-transdermal-delivery-system-to-enhance-drug-bioavailability
#7
Mohammed Ali Kassem, Mona Hassan Aboul-Einien, Mai Magdy El Taweel
Felodipine has a very low bioavailability due to first-pass metabolism. The aim of this study was to enhance its bioavailability by transdermal application. Felodipine-loaded transferosomes were prepared by thin-film hydration using different formulation variables. An optimized formula was designed using statistical experimental design. The independent variables were the used edge activator, its molar ratio to phosphatidylcholine, and presence or absence of cholesterol. The responses were entrapment efficiency of transferosomes, their size, polydispersity index, zeta potential, and percent drug released after 8 h...
April 30, 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29687193/development-of-microemulsions-and-microemulgels-for-enhancing-transdermal-delivery-of-kaempferia-parviflora-extract
#8
Worranan Rangsimawong, Paisit Wattanasri, Prasopchai Tonglairoum, Prasert Akkaramongkolporn, Theerasak Rojanarata, Tanasait Ngawhirunpat, Praneet Opanasopit
The purpose of this research was to develop microemulsions (ME) and microemulgels (MG) for enhancing transdermal delivery of Kaempferia parviflora (KP) extract. The methoxyflavones were used as markers. Various formulations of ME and MG containing 10% w/v KP extract were prepared, and the in vitro skin permeation and deposition were investigated. The potential ME system containing oleic acid (5% w/v), Tween 20 (20% w/v), PG (40% w/v), and water (35% w/v) was successfully formulated. ME with 10% w/v limonene (ME-L10%) showed higher methoxyflavones flux than ME-L5%, ME-L1%, ME without limonene, and KP extract in water, respectively...
April 23, 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29676239/transdermal-delivery-of-at1-receptor-antagonists-reduce-blood-pressure-and-reveals-a-vasodilatory-effect-in-kidney-blood-vessels
#9
Vasso Apostolopoulos, Michaila Michalatou, Maria-Eleni Androutsou, Markos Antonopoulos, George Agelis, Anthony Zulli, Tawar Qaradakhi, John Matsoukas
BACKGROUND: The Renin Angiotensin System (RAS) is pharmacologically targeted to reduce blood pressure, and patient compliance to oral medications is a clinical issue. The mechanisms of action of angiotensin receptor blockers (ARBs) in reducing blood pressure are not well understood, and is purported to be via a reduction of angiotensin II signaling. OBJECTIVE: We aimed to develop a transdermal delivery method for ARBs (losartan potassium and valsartan) and to determine if ARBs reveal a vasodilatory effect of the novel RAS peptide, alamandine...
April 19, 2018: Current Molecular Pharmacology
https://www.readbyqxmd.com/read/29670005/dendrimers-for-drug-delivery
#10
Abhay Singh Chauhan
Dendrimers have come a long way in the last 25 years since their inception. Originally created as a wonder molecule of chemistry, dendrimer is now in the fourth class of polymers. Dr. Donald Tomalia first published his seminal work on Poly(amidoamine) (PAMAM) dendrimers in 1985. Application of dendrimers as a drug delivery system started in late 1990s. Dendrimers for drug delivery are employed using two approaches: (i) formulation and (ii) nanoconstruct. In the formulation approach, drugs are physically entrapped in a dendrimer using non-covalent interactions, whereas drugs are covalently coupled on dendrimers in the nanoconstruct approach...
April 18, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29651933/alternative-methods-to-animal-studies-for-the-evaluation-of-topical-transdermal-drug-delivery-systems
#11
Maria Teresa Junqueira Garcia, Fabia Leal Lopes Vasconcelos, Chloe Patricia Raffier, Michael Stephen Roberts, Jeffrey Ernest Grice, Heather Ann Elizabeth Benson, Vania Rodrigues Leite-Silva
It is critical to develop an effective understanding of the interaction between the drug, delivery system and skin in order to predict and assess skin penetration and permeation. Experimental models for the assessment of topical and transdermal delivery systems must permit evaluation of these complex interactions. Whilst in the past animal models were commonly used, recent regulatory guidelines, based on 3R principles (refinement, reduction, replacement), encourage the rational use of animals. Alternative methods have been proposed for use in the development of topical and transdermal delivery systems which are often used in combination...
April 12, 2018: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/29649624/halloysite-nanotubes-for-efficient-loading-stabilization-and-controlled-release-of-insulin
#12
Marina Massaro, Giuseppe Cavallaro, Carmelo G Colletti, Giuseppe D'Azzo, Susanna Guernelli, Giuseppe Lazzara, Silvia Pieraccini, Serena Riela
HYPOTHESIS: Oral insulin administration is not actually effective due to insulin rapid degradation, inactivation and digestion by proteolytic enzymes which results in low bioavailability. Moreover insulin is poorly permeable and lack of lipophilicity. These limits can be overcome by the loading of protein in some nanostructured carrier such as halloysite nanotubes (HNTs). EXPERIMENTS: Herein we propose an easy strategy to obtain HNT hybrid materials for the delivery of insulin...
April 6, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29626721/curcumin-loaded-ultradeformable-nanovesicles-as-a-potential-delivery-system-for-breast-cancer-therapy
#13
Salma M Abdel-Hafez, Rania M Hathout, Omaima A Sammour
In the current study, the transdermal route has been investigated to deliver the poorly bioavailable drug; curcumin into the systemic circulation, aiming to target both superficial and subcutaneous tumors such as the breast tumors. Accordingly, different colloidal carriers viz. ultradeformable nanovesicles comprising various penetration enhancers were exploited. Curcumin-loaded deformable vesicles were prepared by the thin film hydration method followed by extrusion. Sodium cholate and Tween 80 were set as standard edge activators and Labrasol, Transcutol, limonene and oleic acid were the penetration enhancers that were evaluated for their efficacy in skin permeation...
March 30, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29625213/mechanistic-insights-of-the-controlled-release-properties-of-amide-adhesive-and-hydroxyl-adhesive
#14
Zheng Luo, Xiaocao Wan, Chao Liu, Liang Fang
Although interactions between drugs and acrylate pressure sensitive adhesives (PSAs) containing amide groups were reported in the previous studies, detailed studies elucidating their mechanism of action are still lacking. In the present study, an amide PSA (AACONH2 ) and a hydroxyl PSA (AAOH, as the control) were synthesized, and their molecular mechanism of controlled drug release was described. Using zolmitriptan (ZOL) and etodolac (ETO) as model drugs, in vitro drug release and skin permeation experiments were performed...
April 3, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29604374/insulin-delivery-systems-combined-with-microneedle-technology
#15
Xuan Jin, Dan Dan Zhu, Bo Zhi Chen, Mohammad Ashfaq, Xin Dong Guo
Diabetes, a metabolic disorder of glucose, is a serious chronic disease and an important public health problem. Insulin is one of the hormones for modulating blood glucose level and the products of which is indispensable for most diabetes patients. Introducing microneedles (MNs) to insulin delivery is promising to pave the way for modulating glucose level noninvasively of diabetes patients, as which born to be painless, easy to handle and no need of any power supply. In this work, we review the process of insulin delivery systems (IDSs) based on MN technology in terms of two categories: drug free MNs and drug loaded MNs...
March 28, 2018: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29587456/review-of-stratum-corneum-impedance-measurement-in-non-invasive-penetration-application
#16
REVIEW
Fei Lu, Chenshuo Wang, Rongjian Zhao, Lidong Du, Zhen Fang, Xiuhua Guo, Zhan Zhao
Due to advances in telemedicine, mobile medical care, wearable health monitoring, and electronic skin, great efforts have been directed to non-invasive monitoring and treatment of disease. These processes generally involve disease detection from interstitial fluid (ISF) instead of blood, and transdermal drug delivery. However, the quantitative extraction of ISF and the level of drug absorption are greatly affected by the individual's skin permeability, which is closely related to the properties of the stratum corneum (SC)...
March 26, 2018: Biosensors
https://www.readbyqxmd.com/read/29581043/combinations-of-nanovesicles-and-physical-methods-for-enhanced-transdermal-delivery-of-a-model-hydrophilic-drug
#17
Barbara Zorec, Špela Zupančič, Julijana Kristl, Nataša Pavšelj
Here, we combined lipid nanovesicles (ethosomes, liposomes) as the drug carrier systems with two physical methods (electroporation, sonoporation) to enhance transdermal delivery of a hydrophilic model molecule, calcein. First, using different formulations, ethosomes greatly enhanced calcein permeation by passive diffusion compared to liposomes and calcein in buffer, which is most likely due to a synergism between the ethanol action on the stratum corneum lipids and the penetration of the elastic vesicles. Liposomes permeated poorly through the skin and, as also suggested by other authors, seem to remain confined to the outer layers of the skin...
March 23, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29572160/biomaterials-for-drug-delivery-patches
#18
REVIEW
Lúcia F Santos, Ilídio J Correia, A Sofia Silva, João F Mano
The limited efficiency of conventional drugs has been instigated the development of new and more effective drug delivery systems (DDS). Transdermal DDS, are associated with numerous advantages such its painless application and less frequent replacement and greater flexibility of dosing, features that triggered the research and development of such devices. Such systems have been produced using either biopolymer; or synthetic polymers. Although the first ones are safer, biocompatible and present a controlled degradation by human enzymes or water, the second ones are the most currently available in the market due to their greater mechanical resistance and flexibility, and non-degradation over time...
March 20, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29571251/hyaluronic-acid-modified-nanostructured-lipid-carriers-for-transdermal-bupivacaine-delivery-in-vitro-and-in-vivo-anesthesia-evaluation
#19
Yaocun Yue, Dandan Zhao, Qiuwen Yin
For effective transdermal local anesthetic therapy, to reduce the barrier of stratum corneum and improve the antinociceptive effect, hyaluronic acid (HA) modified, bupivacaine (BPV) loaded nanostructured lipid carriers (NLCs) were designed. HA and linoleic acid (LOA) conjugated propylene glycol (PEG) was synthesized (HA-PEG-LOA). HA-PEG-LOA was added during the preparation process of NLCs, thus LOA was inserted into the NLCs, The physicochemical properties of NLCs, particle size, zeta potential, drug loading capacity, in vitro skin permeation, drug release profiles and in vivo therapeutic effect were evaluated...
February 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29557244/fabrication-of-novel-elastosomes-for-boosting-the-transdermal-delivery-of-diacerein-statistical-optimization-ex-vivo-permeation-in-vivo-skin-deposition-and-pharmacokinetic-assessment-compared-to-oral-formulation
#20
Diana E Aziz, Aly A Abdelbary, Abdelhalim I Elassasy
Diacerein (DCN) is a hydrophobic osteoarthritis (OA) drug with short half-life and low oral bioavailability. Furthermore, DCN oral administration is associated with diarrhea which represents obstacle against its oral use. Hence, this article aimed at developing elastosomes (edge activator (EA)-based vesicular nanocarriers) as a novel transdermal system for delivering DCN efficiently and avoiding its oral problems. For achieving this goal, elastosomes were prepared according to 41 .21 full factorial design using different EAs in varying amounts...
November 2018: Drug Delivery
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