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https://www.readbyqxmd.com/read/27910752/submicron-emulsions-and-their-applications-in-oral-delivery
#1
Veenu Mundada, Mitali Patel, Krutika Sawant
A "submicron emulsion" is an isotropic mixture of drug, lipids, and surfactants, usually with hydrophilic cosolvents and with droplet diameters ranging from 10 to 500 nm. Submicron emulsions are of increasing interest in medicine due to their kinetic stability, high solubilizing capacity, and tiny globule size. Because of these properties, they have been applied in various fields, such as personal care, cosmetics, health care, pharmaceuticals, and agrochemicals. Submicron emulsions are by far the most advanced nanoparticulate systems for the systemic delivery of biologically active agents for controlled drug delivery and targeting...
2016: Critical Reviews in Therapeutic Drug Carrier Systems
https://www.readbyqxmd.com/read/27904078/effect-of-nerolidol-and-or-levulinic-acid-on-the-thermotropic-behavior-of-lipid-lamellar-structures-in-the-stratum-corneum
#2
Shunichi Utsumi, Tomohiro Nakamura, Yasuko Obata, Noboru Ohta, Kozo Takayama
Permeation enhancers are required to deliver drugs through the skin efficiently and maintain effective blood concentrations. Studies of the barrier function of the stratum corneum using l-menthol, a monocyclic monoterpene widely used in medicines and foods, have revealed an interaction between characteristic intercellular lipid structures in the stratum corneum and permeation enhancers. The variety of permeation enhancers that can be used to contribute to transdermal delivery systems beyond l-menthol is increasing...
2016: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27886163/alghedon-fentanyl-transdermal-system-afts
#3
Patrizia Romualdi, Patrizia Santi, Sanzio Candeletti
The efficacy of transdermal fentanyl for cancer pain and chronic non-cancer pain (chronic lower back pain, rheumatoid arthritis, osteoarthritis, neuropathic pain) is well established. Several formulations of fentanyl transdermal systems have been developed to improve the drug delivery and prevent misuse of the active principle. The addition of a rate controlling membrane to the matrix system represented an important advance. The design and functional features of Alghedon patch are compared with other approved generic fentanyl transdermal systems, emphasizing the distinctiveness of Alghedon patch...
November 25, 2016: Minerva Medica
https://www.readbyqxmd.com/read/27885995/transdermal-delivery-of-estradiol-loaded-plga-nanoparticles-using-iontophoresis-for-treatment-of-osteoporosis
#4
Issei Takeuchi, Kohta Fukuda, Shiori Kobayashi, Kimiko Makino
BACKGROUND: Estradiol is one of the therapeutic agents for osteoporosis. We have reported transdermal permeability of estradiol-loaded nanoparticles, and permeability effect of estradiol was enhanced by using nanoparticle system and iontophoresis [Colloids and Surfaces B: Biointerfaces97 (2012), 84-89]. OBJECTIVE: This study was conducted in vivo to evaluate therapeutic efficacy of the estradiol-loaded PLGA nanoparticles for osteoporosis. METHODS: Prior to the in vivo study, we have determined the surface charge density of the particles and found they have negatively charged polyelectrolyte layers on the surfaces...
November 25, 2016: Bio-medical Materials and Engineering
https://www.readbyqxmd.com/read/27877042/effects-of-carbopol-%C3%A2-934-proportion-on-nanoemulsion-gel-for-topical-and-transdermal-drug-delivery-a-skin-permeation-study
#5
Yin Zheng, Wu-Qing Ouyang, Yun-Peng Wei, Shahid Faraz Syed, Chao-Shuang Hao, Bo-Zhen Wang, Yan-Hong Shang
Nanoemulsions (NEs) are used as transdermal drug delivery systems for systematic therapeutic purposes. We hypothesized that the skin permeation profile of an NE could be modulated by incorporating it into a hydrogel containing differing proportions of thickening agent. The objectives of this study were as follows: 1) to determine the stability and skin irritability of NE gels (NGs) containing 1%, 2%, and 3% (w/w) Carbopol(®) 934 (CP934) (termed NG1, NG2, and NG3, respectively); 2) to compare the skin permeation profiles and drug deposition patterns of the NGs; and 3) to visualize the drug delivery routes of the NGs...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27876425/how-can-lipid-nanocarriers-improve-transdermal-delivery-of-olanzapine
#6
Nimra Iqbal, Carla Vitorino, Kevin M G Taylor
The development of a transdermal nanocarrier drug delivery system with potential for the treatment of psychiatric disorders, such as schizophrenia and bipolar disorder, is described. Lipid nanocarriers (LN), encompassing various solid:liquid lipid compositions were formulated and assessed as potential nanosystems for transdermal delivery of olanzapine. A previously optimized method of hot high pressure homogenization (HPH) was adopted for the production of the LN, which comprised solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC) and nanoemulsions (NE)...
November 23, 2016: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/27871215/formulation-characterization-and-in-vitro-ex-vivo-evaluation-of-quercetin-loaded-microemulsion-for-topical-application
#7
Azar Kajbafvala, Alireza Salabat, Anayatollah Salimi
The aim of this study was to develop a new microemulsion formulation for topical application of poorly soluble drug named quercetin. In order to design suitable microemulsion system, the pseudo-ternary phase diagrams of microemulsion systems were constructed at different surfactant/co-surfactant ratios using tween 80 as surfactant, transcutol® P as co-surfactant and oleic acid as oil phase. Some physicochemical properties such as droplet size, density, refractive index, electrical conductivity, pH, surface tension and viscosity of the microemulsion systems were measured at 298...
November 22, 2016: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/27867112/hydrogel-thickened-nanoemulsions-based-on-essential-oils-for-topical-delivery-of-psoralen-permeation-and-stability-studies
#8
Thaís Nogueira Barradas, Juliana Perdiz Senna, Stephani Araujo Cardoso, Sara Nicoli, Cristina Padula, Patrizia Santi, Francesca Rossi, K Gyselle de Holanda E Silva, Claudia R Elias Mansur
Nanoemulsions (NE) have attracted much attention due to their as dermal delivery systems for lipophilic drugs such as psoralens. However, NE feature low viscosity which might be unsuitable for topical application. In this work, we produced hydrogel-thickened nanoemulsions (HTN) using chitosan as thickening polymer to overcome the low viscosity attributed to NE. The aim of this study is to develop and characterize oil-in-water (o/w) HTN based on sweet fennel and clove essential oil to transdermal delivery of 8-methoxsalen (8-MOP)...
November 17, 2016: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/27866687/glibenclamide-nanocrystals-in-a-biodegradable-chitosan-patch-for-transdermal-delivery-engineering-formulation-and-evaluation
#9
Hany S M Ali, Ahmed F Hanafy
Glibenclamide (GBD) nanocrystals (D50 = 429 nm) were engineered by applying combined precipitation and homogenization procedures. GBD crystallinity was maintained during the nanonization process as revealed by differential scanning calorimetry and X-ray analyses. Nanonized and micronized GBD were incorporated into chitosan solutions to fabricate transdermal delivery systems (TDDSs), nano- and micro-GBD, respectively. The fabricated TDDSs displayed satisfactory physicochemical characteristics without substantial aggregation of GBD nanocrystals during the casting and drying procedures...
November 17, 2016: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27865983/transdermal-therapeutic-systems-for-memantine-delivery-comparison-of-passive-and-iontophoretic-transport
#10
S Del Río-Sancho, C E Serna-Jiménez, M Sebastián-Morelló, M A Calatayud-Pascual, C Balaguer-Fernández, A Femenía-Font, Y N Kalia, V Merino, A López-Castellano
Memantine is a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist used in the treatment of moderate to severe dementia including the symptoms of Alzheimer's disease (AD). It is administered orally but compliance, swallowing problems and the routine use of multiple medications in elderly AD patients means that an alternative route of administration would be of interest. The aim of the present study was to develop memantine hydrochloride occlusive transdermal therapeutic systems (TTS) for passive and iontophoretic delivery across the skin...
November 16, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27865609/recent-advances-in-lipid-based-vesicles-and-particulate-carriers-for-topical-and-transdermal-application
#11
REVIEW
Shashank Jain, Niketkumar Patel, Mansi K Shah, Pinak Khatri, Namrata Vora
In the recent decade, skin delivery (topical and transdermal) has gained an unprecedented popularity, especially due to increased incidences of chronic skin diseases, demand for targeted and patient compliant delivery, and interest in life cycle management strategies among pharmaceutical companies. Literature review of recent publications indicates that among various skin delivery systems, lipid-based delivery systems (vesicular carriers and lipid particulate systems) have been the most successful. Vesicular carriers consist of liposomes, ultradeformable liposomes, and ethosomes, while lipid particulate systems consist of lipospheres, solid lipid nanoparticles, and nanostructured lipid carriers...
November 16, 2016: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27863672/hot-melt-extruded-transdermal-films-based-on-amorphous-solid-dispersions-in-eudragit-rs-po-the-inclusion-of-hydrophilic-additives-to-develop-moisture-activated-release-systems
#12
Esra'a Albarahmieh, Sheng Qi, Duncan Q M Craig
A series of Eudragit RS PO-based hot melt extruded films were evaluated as potential transdermal systems, with particular emphasis on the inclusion of hydrophilic excipients to allow water sorption, which in turn would allow drug release on application to the skin. More specifically, sucrose, methyl cellulose, xanthan gum (Xantural(®)75), poloxamer (Pluronic(®)F127), Gelucire 44/14 were added to Eudragit RS PO and assessed in terms of physical structure (modulated temperature DSC (MTDSC), thermogravimetric analysis (TGA), powder XRD (PXRD), scanning electron microscopy(SEM)) and in vitro drug release and permeation properties...
November 30, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27858253/microemulsion-transdermal-formulation-for-simultaneous-delivery-of-valsartan-and-nifedipine-formulation-by-design
#13
Jatin Sood, Bharti Sapra, Ashok K Tiwary
The objective of the study was to optimize the proportion of different components for formulating oil in water microemulsion formulation meant for simultaneous transdermal delivery of two poorly soluble antihypertensive drugs. Surface response methodology of Box-Behnken design was utilized to evaluate the effect of two oils (Captex 500 - x1 and Capmul MCM - x2) and surfactant (Acrysol EL135 - x3) on response y1 (particle size), y2 (solubility of valsartan), and y3 (solubility of nifedipine). The important factors which significantly affected the responses were identified and validated using ANOVA...
November 17, 2016: AAPS PharmSciTech
https://www.readbyqxmd.com/read/27854292/the-influence-of-solid-microneedles-on-the-transdermal-delivery-of-selected-antiepileptic-drugs
#14
Julia Nguyen, Kevin B Ita, Matthew J Morra, Inna E Popova
The aim of this project was to examine the effect of microneedle rollers on the percutaneous penetration of tiagabine hydrochloride and carbamazepine across porcine skin in vitro. Liquid chromatography-mass spectrometric analysis was carried out using an Agilent 1200 Series HPLC system coupled to an Agilent G1969A TOF-MS system. Transdermal flux values of the drugs were determined from the steady-state portion of the cumulative amount versus time curves. Following twelve hours of microneedle roller application, there was a 6...
November 15, 2016: Pharmaceutics
https://www.readbyqxmd.com/read/27854180/microwave-grafted-composite-and-coprocessed-materials-drug-delivery-applications
#15
Loveleen Kaur, Inderbir Singh
Novel modified pharmaceutical materials with desired functionalities are required for the development of drug delivery systems. Excipients are no more inert ingredients but these are playing crucial roles in modifying physicochemical properties of drugs and for imparting desired functionalities in the delivery system. In this review article, modified materials such as grafted, composite and coprocessed have been discussed along with the updated reported literature on the same. Applications of grafted materials as drug release retardant, mucoadhesive polymer and tablet superdisintegrant have been elaborated...
November 17, 2016: Therapeutic Delivery
https://www.readbyqxmd.com/read/27837534/elastic-liposomes-for-topical-and-transdermal-drug-delivery
#16
Heather A E Benson
Elastic liposomes have been developed and evaluated as novel topical and transdermal delivery systems. They share some similarities to conventional liposomes but their composition is designed to confer flexibility and elasticity in the lipid bilayer structure. Elastic liposomes are applied non-occluded to the skin and are reported to permeate through the stratum corneum lipid lamellar regions as a result of the hydration or osmotic force in the skin. They have been investigated as drug carriers for a range of small molecules, peptides, proteins, and vaccines, both in vitro and in vivo...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27834056/ultradeformable-liposomes-a-novel-vesicular-carrier-for-enhanced-transdermal-delivery-of-procyanidins-effect-of-surfactants-on-the-formation-stability-and-transdermal-delivery
#17
Rencai Chen, Rongli Li, Qian Liu, Chao Bai, Benlin Qin, Yue Ma, Jing Han
The aims of this work were to develop a novel vesicular carrier, procyanidins, ultradeformable liposomes (PUDLs), to expand the applications for procyanidins, and increase their stability and transdermal delivery. In this study, we prepared procyanidins ultradeformable liposomes using thin film hydration method and evaluated their encapsulation efficiency, vesicle deformability, storage stability, and skin permeation in vitro. The influence of different surfactants on the properties of PUDLs was also investigated...
November 10, 2016: AAPS PharmSciTech
https://www.readbyqxmd.com/read/27832955/lipid-vesicular-nanocarrier-quick-encapsulation-efficiency-determination-and-transcutaneous-application
#18
Yibang Zhang, Weibeng Ng, Xue Feng, Fangying Cao, Huaxi Xu
Nanoscale delivery systems have been widely investigated to overcome the penetration barrier of stratum corneum for effective transcutaneous application. The aim of this study is the development of effective vesicular formulations of ovalbumin and saponin which are able to promote penetration through the skin layers. Three kinds of vesicular formulations have been investigated as carriers, including liposomes, transfersomes and ethosomes, in which cholesterol and/or cationic lipid stearylamine are incorporated...
November 8, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27830857/5-aminolevulinic-acid-loaded-ethosomal-vesicles-with-high-entrapment-efficiency-for-in-vitro-topical-transdermal-delivery-and-photodynamic-therapy-of-hypertrophic-scars
#19
Zheng Zhang, Yunsheng Chen, Heng Xu, Yan Wo, Zhen Zhang, Ying Liu, Weijie Su, Daxiang Cui, Yixin Zhang
Photodynamic therapy (PDT) with 5-aminolevulinic acid (ALA) is an alternative therapy for hypertrophic scars (HS), which destroys human hypertrophic scar fibroblasts (HSF). However, the poor permeability of ALA both in HS tissue and HSF significantly restricts the PDT of HS. To overcome these barriers, ALA-loaded ethosomal vesicles (ALA-ES) were developed by a pH gradient active loading method and characterized by morphology, entrapment efficiency (EE) and stability. Results show that prepared ALA-ES are homogenous spherical lamellar vesicles, 53 ± 7 nm in size, 50...
November 10, 2016: Nanoscale
https://www.readbyqxmd.com/read/27828696/current-and-investigational-medication-delivery-systems-for-treating-attention-deficit-hyperactivity-disorder
#20
Rakesh Jain, Alain Katic
OBJECTIVE: To review currently available formulations and emphasize unmet needs in the pharmacologic management of attention-deficit/hyperactivity disorder (ADHD). DATA SOURCES: Publications and clinical trials were identified through PubMed and ClinicalTrials.gov, respectively. A Web-based search identified prescribing information for approved agents for treating ADHD, along with relevant guidelines and diagnostic criteria. STUDY SELECTION: The following search terms were used: (1) ADHD or attention-deficit/hyperactivity disorder or ADD or attention deficit hyperactivity disorder and/or (2) amphetamine or methylphenidate or atomoxetine or guanfacine or clonidine...
August 18, 2016: Primary Care Companion to CNS Disorders
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