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transdermal delivery system

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https://www.readbyqxmd.com/read/29141479/development-of-a-carboxymethyl-chitosan-functionalized-nanoemulsion-formulation-for-increasing-aqueous-solubility-stability-and-skin-permeability-of-astaxanthin-using-low-energy-method
#1
Liang Hong, Chuan-Li Zhou, Feng-Ping Chen, Dan Han, Chun-Yuan Wang, Jia-Xin Li, Zhe Chi, Chen-Guang Liu
In this research, firstly astaxanthin (ASX)-loaded nanoemulsions (NEs) were produced using a convenient low-energy emulsion phase inversion method. The optimised ASX-NEs were prepared in the presence of Cremophor(®) EL and Labrafil(®) M 1944 CS, with a surfactant-to-oil ratio of 4:6. The ASX-NE droplets were spherical with a mean droplet diameter below 100 nm and a small negative surface charge. The system was stable without alteration of mean droplet diameter for three months. Then, the ASX-NE was functionalised with carboxymethyl chitosan (CMCS) through direct CMCS (0...
November 15, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/29130758/proniosomes-derived-niosomes-recent-advancements-in-drug-delivery-and-targeting
#2
Maryam Khatoon, Kifayat Ullah Shah, Fakhar Ud Din, Shefaat Ullah Shah, Asim Ur Rehman, Naz Dilawar, Ahmad Nawaz Khan
Vesicular drug delivery systems have gained wide attention in the field of nanotechnology. Among them proniosomes become the superior over other vesicular carriers. Proniosomes are dry formulations of water soluble nonionic surfactant coated carrier system which immediately forms niosomes upon hydration. They have the capability to overcome the instability problems associated with niosomes and liposomes and have the potential to improve solubility, bioavailability, and absorption of various drugs. Furthermore, they offer versatile drug delivery concept for enormous number of hydrophilic and hydrophobic drugs...
2017: Drug Delivery
https://www.readbyqxmd.com/read/29116267/permeation-pathways-through-lateral-domains-in-model-membranes-of-skin-lipids
#3
Annalaura Del Regno, Rebecca Notman
An understanding of how molecules permeate the complex lipid matrix of the stratum corneum (SC) skin barrier is important for transdermal drug delivery, preventing the adsorption of toxic chemicals and tackling skin diseases. In this paper we present atomistic molecular dynamics simulations of skin-lipid bilayers composed of ceramides, cholesterol (CHOL) and free fatty acids at different lipid compositions and levels of hydration and investigate both perpendicular and lateral permeation pathways through the systems...
November 8, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29111097/lipid-nanocarriers-as-skin-drug-delivery-systems-properties-mechanisms-of-skin-interactions-and-medical-applications
#4
REVIEW
M Sala, R Diab, A Elaissari, H Fessi
During the past decades, lipid nanocarriers are gaining momentum with their multiple advantages for the management of skin diseases. Lipid nanocarriers enable to target the therapeutic payload to deep skin layers or even to reach the blood circulation making them a promising cutting-edge technology. Lipid nanocarriers refer to a large panel of drug delivery systems. Lipid vesicles are the most conventional, known to be able to carry lipophilic and hydrophilic active agents. A variety of lipid vesicles with high flexibility and deformability could be obtained by adjusting their composition; namely ethosomes, transfersomes and penetration enhancer lipid vesicles which achieve the best results in term of skin permeation...
October 27, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29103509/physicochemical-study-of-ascorbic-acid-2-glucoside-loaded-hyaluronic-acid-dissolving-microneedles-irradiated-by-electron-beam-and-gamma-ray
#5
Suyong Kim, Jeongwon Lee, F Lahiji Shayan, Seohyun Kim, Inyoung Huh, Yonghao Ma, Huisuk Yang, Geonwoo Kang, Hyungil Jung
A dissolving microneedle (DMN) patch encapsulated with ascorbic acid 2-glucoside (AA2G) in a needle-shaped hyaluronic acid (HA) backbone was fabricated and sterilized by electron beam (e-beam, 5-40kGy) and gamma ray (γ-ray, 5-30kGy). DMN structures maintained their morphologies and fracture force regardless of e-beam and γ-ray irradiation doses. Both e-beam (40kGy) and γ-ray (20 and 30kGy) met the product sterility requirements for cosmetics and vaccines; however, γ-ray irradiation significantly degraded the encapsulated AA2G, while e-beam maintained AA2G activity...
January 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29098871/design-of-antihistaminic-transdermal-films-based-on-alginate-chitosan-polyelectrolyte-complexes-characterization-and-permeation-studies
#6
Sonia Lefnaoui, Nadji Moulai-Mostefa, Madiha M Yahoum, Sarah N Gasmi
The purpose of this study was to develop suitable matrix type transdermal drug delivery systems of Ketotifen fumarate (KF) as antiasthmatic drugs. Chitosan-alginate polyelectrolyte complex (PEC) films were used as drug release regulators for KF. Antihistaminic films with variable PEC compositions were prepared using different ratios of chitosan (CTS) to sodium alginate (ALG). Propylene glycol (PG) was used as plasticizer; Tween 80 (T80) and Span 20 (S20) were used as permeability enhancers. Nine formulations were obtained by film casting method and characterized in terms of weight uniformity, thickness, folding endurance, moisture lost, and moisture absorption...
November 3, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29093350/in-vivo-microdialysis-for-dynamic-monitoring-of-the-effectiveness-of-nano-liposomes-as-vehicles-for-topical-psoralen-application
#7
Hongyu Zhang, Kai Zhang, Zhe Li, Jihui Zhao, Yongtai Zhang, Nianping Feng
In this study, the skin permeation of liposomes containing psoralen was investigated by in vivo skin microdialysis. Psoralen-loaded nano-sized liposomes were prepared with a mean size of 117.5 nm and a polydispersity index of 0.21, indicating the uniform dispersion of phosphatidylcholine vesicles in the liposomal solution. Based on in vivo microdialysis experiments, the drug concentration in local deep skin of rat increased rapidly and reached a peak concentration (Cmax) of 319.35±23.72 µg/mL at 180 min, and decreased slowly thereafter...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29057820/oil-body-bound-oleosin-rhfgf-10-a-novel-drug-delivery-system-that-improves-skin-penetration-to-accelerate-wound-healing-and-hair-growth-in-mice
#8
Wenqing Li, Jing Yang, Jingbo Cai, Hongyu Wang, Haishan Tian, Jian Huang, Weidong Qiang, Linbo Zhang, Haiyan Li, Xiaokun Li, Chao Jiang
Recombinant human fibroblast growth factor 10 (rhFGF-10) is frequently used to treat patients with skin injuries. It can also promote hair growth. However, the effective application of rhFGF-10 is limited because of its poor stability and transdermal absorption. In this study, polymerase chain reaction (PCR) and Southern blotting were used to identify transgenic safflowers carrying a gene encoding an oleosin-rhFGF-10 fusion protein. The size and structural integrity of oleosin-rhFGF-10 in oil bodies extracted from transgenic safflower seeds was characterized by polyacrylamide gel electrophoresis and western blotting...
October 18, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29051119/novel-dissolving-microneedles-for-enhanced-transdermal-delivery-of-levonorgestrel-in-vitro-and-in-vivo-characterization
#9
Gangtao Yao, Guilan Quan, Shiqi Lin, Tingting Peng, Qingqing Wang, Hao Ran, Hangping Chen, Qian Zhang, Lili Wang, Xin Pan, Chuanbin Wu
Dissolving microneedles (DMN) have been studied as a drug delivery system to enhance the transport of drug molecules across the skin with almost no pain. However, the poor dissolving ability of microneedles in the skin and low drug loading have limited their potential application. The aim of this study was to develop a novel dissolving microneedle system with improved dissolving ability for the delivery of poorly water soluble contraception drug, levonorgestrel (LNG). Chitosan and beta-sodium glycerophosphate (β-GP) were incorporated in the formulation of microneedles...
October 16, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29037785/novel-bilayer-dissolving-microneedle-arrays-with-concentrated-plga-nano-microparticles-for-targeted-intradermal-delivery-proof-of-concept
#10
Lalit K Vora, Ryan F Donnelly, Eneko Larraneta, Patricia González-Vázquez, Raghu Raj Singh Thakur, Pradeep R Vavia
Polymeric microneedle (MN) arrays continue to receive growing attention due to their ability to bypass the skin's stratum corneum barrier in a minimally-invasive fashion and achieve enhanced transdermal drug delivery and "targeted" intradermal vaccine administration. In this research work, we fabricated biodegradable bilayer MN arrays containing nano - microparticles for targeted and sustained intradermal drug delivery. For this study, model drug (vitamin D3, VD3)-loaded PLGA nano- and microparticles (NMP) were prepared by a single emulsion solvent evaporation method with 72...
October 13, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29035818/skin-penetrating-polymeric-nanoparticles-incorporated-in-silk-fibroin-hydrogel-for-topical-delivery-of-curcumin-to-improve-its-therapeutic-effect-on-psoriasis-mouse-model
#11
Kai-Li Mao, Zi-Liang Fan, Jian-Dong Yuan, Pian-Pian Chen, Jing-Jing Yang, Jie Xu, De-Li ZhuGe, Bing-Hui Jin, Qun-Yan Zhu, Bi-Xin Shen, Yasin Sohawon, Ying-Zheng Zhao, He-Lin Xu
A poor percutaneous penetration capability for most topical anti-inflammatory drugs is one of the main causes compromising their therapeutic effects on psoriatic skin. Even though curcumin has shown a remarkable efficacy in the treatment of psoriasis, its effective penetration through the stratum corneum is still a major challenge during transdermal delivery. The aim of our study was to design skin-permeating nanoparticles (NPs) to facilitate delivery of curcumin to the deeper layers of the skin. A novel amphiphilic polymer, RRR-α-tocopheryl succinate-grafted-ε-polylysine conjugate (VES-g-ε-PLL) was synthesized and self-assembled into polymeric nanoparticles...
October 10, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28976043/advances-in-ph-sensitive-polymers-for-smart-insulin-delivery
#12
REVIEW
Jing Xie, Anqi Li, Jianshu Li
Since diabetes mellitus has become one of the most serious threats to human health, researchers have been designing new drugs and developing new technologies to control the blood glucose level (BGL) while improving patient compliance. In addition to the traditional subcutaneous injection method, alternative routes of insulin delivery have been investigated and tested, including oral, pulmonary, transdermal, and nasal. The final goal of all these technologies is to develop a system that releases insulin in a controlled manner depending on the BGL...
October 4, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/28969565/design-and-evaluation-of-transdermal-patches-of-timolol-maleate
#13
S P Hiremath, J Jujjuri, V J Jamakandi
BACKGROUND: Continuous intravenous infusion of controlled drug delivery has certain risks. This could be diligently duplicated devoid of its hassles by using the skin as the port of drug entry. Transdermal drug delivery system is the main route with discrete, self-contained dosage forms when placed on the skin transports the medicament through the skin into the systemic circulation in a well-controlled manner. OBJECTIVE: The rationale of the current work was to formulate and evaluate a transdermal patch of an antihypertensive drug by using different grades of polymers with a view to circumvent the hepatic first pass metabolism and also to escalate its bioavailability...
October 2, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28948909/transdermal-lipid-nanocarriers-a-potential-delivery-system-for-lornoxicam
#14
Sandipan Dasgupta, Subhabrata Ray, Sanjay Dey, Paulami Pal, Bhaskar Mazumder
BACKGROUND: Lornoxicam, is a NSAID of the oxicam class. Its short duration of action owing to rapid elimination and gastrointestinal side effects limits its usefulness when administered orally. OBJECTIVE: The primary objective of the proposed work is to develop suitable lipid nanocarriers for transdermal delivery of Lornoxicam with increased drug residence time at local site of inflamation and in systemic circulation, overcoming undesired gastrointestinal side effects...
2017: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/28948854/in-vitro-evaluation-of-archaeosome-vehicles-for-transdermal-vaccine-delivery
#15
Yimei Jia, Michael J McCluskie, Dongling Zhang, Robert Monette, Umar Iqbal, Maria Moreno, Janelle Sauvageau, Dean Williams, Lise Deschatelets, Zygmunt J Jakubek, Lakshmi Krishnan
Archaeosomes composed of archaeal total polar lipids (TPL) or semi-synthetic analog vesicles have been used as vaccine adjuvants and delivery systems in animal models for many years. Typically administered by intramuscular or subcutaneous injections, archaeosomes can induce robust, long-lasting humoral and cell-mediated immune responses against entrapped antigens and provide protection in murine models of infectious disease and cancer. Herein, we evaluated various archaeosomes for transdermal delivery, since this route may help eliminate needle-stick injuries and needle re-use, and therefore increase patient compliance...
September 26, 2017: Journal of Liposome Research
https://www.readbyqxmd.com/read/28939519/the-role-of-biopolymer-matrix-films-derived-from-carboxymethyl-cellulose-sodium-alginate-and-polyvinyl-alcohol-on-the-sustained-transdermal-release-of-diltiazem
#16
T S Anirudhan, Anoop S Nair, Gopika Ss
Due to changing lifestyles of modern world, cardiac failures are increasing day by day. Drug delivery systems that can overcome the drawbacks of conventional drug administration are highly desired. Diltiazem hydrochloride (DTZ) is a common and effective drug used for cardiac failures. However, its efficient loading, high bio availability and sustained transdermal release from polymer matrix are of high demand. Herein, the main objective was to fabricate a transdermal drug delivery system (TDDS) capable of efficient DTZ loading with sustained release...
September 19, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28934172/topical-nano-and-microemulsions-for-skin-delivery
#17
REVIEW
Christofori M R R Nastiti, Thellie Ponto, Eman Abd, Jeffrey E Grice, Heather A E Benson, Michael S Roberts
Nanosystems such as microemulsions (ME) and nanoemulsions (NE) offer considerable opportunities for targeted drug delivery to and via the skin. ME and NE are stable colloidal systems composed of oil and water, stabilised by a mixture of surfactants and cosurfactants, that have received particular interest as topical skin delivery systems. There is considerable scope to manipulate the formulation components and characteristics to achieve optimal bioavailability and minimal skin irritancy. This includes the incorporation of established chemical penetration enhancers to fluidize the stratum corneum lipid bilayers, thus reducing the primary skin barrier and increasing permeation...
September 21, 2017: Pharmaceutics
https://www.readbyqxmd.com/read/28929244/analyzing-polymeric-matrix-for-fabrication-of-a-biodegradable-microneedle-array-to-enhance-transdermal-delivery
#18
Kuo-Yuan Hwa, Vincent H S Chang, Yao-Yi Cheng, Yue-Da Wang, Pey-Shynan Jan, Boopathi Subramani, Min-Ju Wu, Bo-Kai Wang
Traditional drug delivery systems, using invasive, transdermal, and oral routes, are limited by various factors, such as the digestive system environment, skin protection, and sensory nerve stimulation. To improve the drug delivery system, we fabricated a polysaccharide-based, dissolvable microneedle-based array, which combines the advantages of both invasive and transdermal delivery systems, and promises to be an innovative solution for minimally invasive drug delivery. In this study, we designed a reusable aluminum mold that greatly improved the efficiency and convenience of microneedle fabrication...
September 19, 2017: Biomedical Microdevices
https://www.readbyqxmd.com/read/28919029/recent-advances-of-controlled-drug-delivery-using-microfluidic-platforms
#19
REVIEW
Sharma T Sanjay, Wan Zhou, Maowei Dou, Hamed Tavakoli, Lei Ma, Feng Xu, XiuJun Li
Conventional systematically-administered drugs distribute evenly throughout the body, get degraded and excreted rapidly while crossing many biological barriers, leaving minimum amounts of the drugs at pathological sites. Controlled drug delivery aims to deliver drugs to the target sites at desired rates and time, thus enhancing the drug efficacy, pharmacokinetics, and bioavailability while maintaining minimal side effects. Due to a number of unique advantages of the recent microfluidic lab-on-a-chip technology, microfluidic lab-on-a-chip has provided unprecedented opportunities for controlled drug delivery...
September 15, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28917875/collagen-and-hyaluronic-acid-hydrogel-in-water-in-oil-microemulsion-delivery-systems
#20
Sylwia Kupper, Ilona Kłosowska-Chomiczewska, Patrycja Szumała
The increase in skin related health issues has promoted interest in research on the efficacy of microemulsion in dermal and transdermal delivery of active ingredients. Here, we assessed the water-in-oil microemulsion capacity to incorporate two natural polymers, i.e. collagen and hyaluronic acid with low and high molecular weight. Systems were extensively characterized in terms of conductivity, phase inversion studies, droplet diameter, polydispersity index and rheological properties. The results of this research indicate that the structure and extent of water phase in microemulsions is governed by ratio and amount of surfactant mixture (sorbitan ester derivatives)...
November 1, 2017: Carbohydrate Polymers
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