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M B Anusha, Naveen Shivanna, G Phani Kumar, K R Anilakumar
The human body on exposure to high-altitude, undergoes many physiological challenges. The cardiopulmonary reserves are favoured against the digestive system. Hence, the efficiency of digestion is compromised to a great extent, which leads to anorexia, hypophagia, epigastralgia, dyspepsia, nausea, and peptic ulcers. The present study was focused on in vitro digestive influence of selected food ingredients viz. cardamom, carom, cumin, coriander, fennel, fenugreek, ginger, pepper, star anise, turmeric, papaya, orange, pineapple, liquorice, valerian, and tarragon on the activities of digestive enzymes of rat pancreas, duodenum, and small intestine...
May 2018: Journal of Food Science and Technology
Tamsin R M Lannagan, Young K Lee, Tongtong Wang, Jatin Roper, Mark L Bettington, Lochlan Fennell, Laura Vrbanac, Lisa Jonavicius, Roshini Somashekar, Krystyna Gieniec, Miao Yang, Jia Q Ng, Nobumi Suzuki, Mari Ichinose, Josephine A Wright, Hiroki Kobayashi, Tracey L Putoczki, Yoku Hayakawa, Simon J Leedham, Helen E Abud, Ömer H Yilmaz, Julie Marker, Sonja Klebe, Pratyaksha Wirapati, Siddhartha Mukherjee, Sabine Tejpar, Barbara A Leggett, Vicki L J Whitehall, Daniel L Worthley, Susan L Woods
OBJECTIVE: Serrated colorectal cancer (CRC) accounts for approximately 25% of cases and includes tumours that are among the most treatment resistant and with worst outcomes. This CRC subtype is associated with activating mutations in the mitogen-activated kinase pathway gene, BRAF , and epigenetic modifications termed the CpG Island Methylator Phenotype, leading to epigenetic silencing of key tumour suppressor genes. It is still not clear which (epi-)genetic changes are most important in neoplastic progression and we begin to address this knowledge gap herein...
April 17, 2018: Gut
Natasha Catlin, Suramya Waidyanatha, Sherry R Black, James Mathews, Rodney W Snyder, Purvi Patel, Scott Watson, Timothy R Fennell
1. Tris(4-chlorophenyl)methane (TCPME) and Tris(4-chlorophenyl)methanol (TCPMOH) have been detected in various biota and human tissues. 2. The current studies were undertaken to investigate the disposition and metabolism of TCPME and TCPMOH in rats and mice. 3. [14 C]TCPME was well absorbed (≥ 66%) in male rats and mice following a single oral administration of 1, 10, or 100 mg/kg. The excretion of [14 C]TCPME-derived radioactivity in urine (≤ 2.5%) and feces (≤18%) was low. The administered dose was retained in tissues (≥ 64%) with adipose containing the highest concentrations...
April 16, 2018: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
Christopher J Helal, Eric P Arnold, Tracey L Boyden, Cheng Chang, Thomas A Chappie, Kimberly F Fennell, Michael D Forman, Mihaly Hajos, John F Harms, William E Hoffman, John M Humphrey, Zhijun Kang, Robin J Kleiman, Bethany L Kormos, Erik A LaChapelle, Che-Wah Lee, Jiemin Lu, Noha Maklad, Laura McDowell, Scot Mente, Rebecca E O'Connor, Jayvardhan Pandit, Mary Piotrowski, Anne W Schmidt, Christopher J Schmidt, Hirokazu Ueno, Patrick R Verhoest, Edward X Yang
No abstract text is available yet for this article.
April 6, 2018: Journal of Medicinal Chemistry
Michael Robinson, Sean Fennell, Brian DiZio, Jennifer Dumiak
Successful synthetic aperture sonar target classification depends on the "shape" of the scatterers within a target signature. This article presents a workflow that computes a target-to-target distance from persistence diagrams, since the "shape" of a signature informs its persistence diagram in a structure-preserving way. The target-to-target distances derived from persistence diagrams compare favorably against those derived from spectral features and have the advantage of being substantially more compact...
March 2018: Journal of the Acoustical Society of America
Christopher J Wilson, Tim Fennell, Anne Bothmer, Morgan L Maeder, Deepak Reyon, Cecilia Cotta-Ramusino, Cecilia A Fernandez, Eugenio Marco, Luis A Barrera, Hariharan Jayaram, Charles F Albright, Gerald F Cox, George M Church, Vic E Myer
No abstract text is available yet for this article.
March 30, 2018: Nature Methods
Hye Won Lee, Hyun-Ja Lim, Ji Hee Jun, Hyun-Suk Lim, Myeong Soo Lee
BACKGROUND: Fennel (Foeniculum vulgare) is often used in women's health care to treat dysmenorrhea, increase the milk supply, and address symptoms of menopause. The object of this review is to evaluate the current evidence on the efficacy of fennel for the management menopausal symptoms. METHODS AND ANALYSES: Thirteen databases will be searched from their inception to the present. These include PubMed, AMED, EMBASE, the Cochrane Library, six Korean medical databases (Korean Studies Information Service System, DBPIA, the Korean Institute of Science and Technology Information, the Research Information Service System, KoreaMed, and the Korean National Assembly Library), and 3 Chinese databases (the China National Knowledge Infrastructure Database [CNKI], the Chongqing VIP Chinese Science and Technology Periodical Database [VIP], and Wanfang Database)...
March 2018: Medicine (Baltimore)
Helen B Pearson, Jason Li, Valerie S Meniel, Christina M Fennell, Paul Waring, Karen G Montgomery, Richard J Rebello, Arthi A Macpherson, Sarah Koushyar, Luc Furic, Carleen Cullinane, Richard W Clarkson, Matthew J Smalley, Kaylene J Simpson, Toby J Phesse, Peter R Shepherd, Patrick O Humbert, Owen J Sansom, Wayne A Phillips
Genetic alterations that potentiate PI3K signalling are frequent in prostate cancer, yet how different genetic drivers of the PI3K cascade contribute to prostate cancer is unclear. Here, we report PIK3CA mutation/amplification correlates with poor prostate cancer patient survival. To interrogate the requirement of different PI3K genetic drivers in prostate cancer, we employed a genetic approach to mutate Pik3ca in mouse prostate epithelium. We show Pik3caH1047R mutation causes p110α-dependent invasive prostate carcinoma in-vivo...
March 26, 2018: Cancer Discovery
Marcelo Valle Garcia, Carlos Augusto Mallmann, Marina Venturini Copetti
During their processing, spices usually remain close to the ground for drying, a fact that disposes to fungal contamination, as well as moisture transferred from the tropical environment can allow their multiplication and synthesis of mycotoxins. The objective of this study was to evaluate the presence of potentially toxigenic fungi and mycotoxins in spices marketed in Brazil. The fungal contamination was evaluated by direct plating for samples of clove, black and white peppers. Spread plate was used for the samples of rosemary, cinnamon, fennel, pepperoni pepper and oregano...
April 2018: Food Research International
Ian Woolhouse, Lesley Bishop, Liz Darlison, Duneesha de Fonseka, Anthony Edey, John Edwards, Corinne Faivre-Finn, Dean A Fennell, Steve Holmes, Keith M Kerr, Apostolos Nakas, Tim Peel, Najib M Rahman, Mark Slade, Jeremy Steele, Selina Tsim, Nick A Maskell
The full guideline for the investigation and management of malignant pleural mesothelioma is published in Thorax . The following is a summary of the recommendations and good practice points. The sections referred to in the summary refer to the full guideline.
2018: BMJ Open Respiratory Research
Marcelo Valle Garcia, Gilson Parussolo, Camila Brombilla Moro, Angélica Olivier Bernardi, Marina Venturini Copetti
The aim of this study was to identify fungal species present in 200 samples of rosemary, fennel, cinnamon, clove, pepperoni, black and white pepper and oregano and evaluate the mycotoxigenic potential of the some Aspergilli isolated. Clove, black and white peppers were analyzed by direct plating. For rosemary, cinnamon, fennel, pepperoni pepper and oregano samples were used spread plate. Mycotoxigenic capacity was verified by the agar plug method. With the exception of clove, all the spices showed high fungal contamination, especially by Aspergillus sp...
August 2018: Food Microbiology
Amanda J McCambridge, Andrea Napolitano, Aaron S Mansfield, Dean A Fennell, Yoshitaka Sekido, Anna K Nowak, Thanyanan Reungwetwattana, Weimin Mao, Harvey I Pass, Michele Carbone, Haining Yang, Tobias Peikert
Malignant pleural mesothelioma (MPM) is an uncommon, almost universally fatal, asbestos-induced malignancy. New and effective strategies for diagnosis, prognostication and treatment are urgently needed. Herein we review the advances in MPM achieved in 2017. While recent epidemiological data demonstrated that the incidence of MPM-related death continued to increase in United States between 2009 and 2015, new insight into the molecular pathogenesis and the immunological tumor microenvironment of MPM, for example, regarding the role of BRCA1 associated protein 1 (BAP1) and the expression programmed death receptor ligand 1 (PD-L1), are highlighting new potential therapeutic strategies...
March 7, 2018: Journal of Thoracic Oncology
Eleni Gkika, Oliver Oehlke, Hatice Bunea, Nicole Wiedenmann, Sonja Adebahr, Ursula Nestle, Constantinos Zamboglou, Simon Kirste, Jamina Fennell, Thomas Brunner, Mark Gainey, Dimos Baltas, Mathias Langer, Horst Urbach, Michael Bock, Philipp T Meyer, Anca-Ligia Grosu
Positron emission tomography and multiparametric MRI provide crucial information concerning tumor extent and normal tissue anatomy. Moreover, they are able to visualize biological characteristics of the tumor, which can be considered in the radiation treatment planning and monitoring. In this review we discuss the impact of biological imaging positron emission tomography and multiparametric MRI for radiation oncology, based on the data of the literature and on the experience of our own institution in this field...
March 9, 2018: Future Oncology
Christopher Joseph Fennell, Neda Ghousifam, Jennifer M Haseleu, Heather Gappa-Fahlenkamp
We present an atomistic level computational investigation of the dynamics of a signaling protein, Monocyte Chemoattractant Protein-1 (MCP-1), that explores how simulation geometry and solution ionic strength affect the calculated diffusion coefficient. Using a simple extension of non-cubic finite size diffusion correction expressions, it is possible to calculate experimentally comparable diffusion coefficients that are fully consistent with those determined from cubic box simulations. Additionally, increasing the concentration of salt in the solvent environment leads to changes in protein dynamics that are not explainable through changes in solvent viscosity alone...
March 6, 2018: Journal of Physical Chemistry. B
Nafiseh Ghassab Abdollahi, Mojgan Mirghafourvand, Sanaz Mollazadeh
Introduction Fennel has many medicinal properties and is used in the treatment of dysmenorrhea. Given the widespread use of herbal medicine among women for menstrual problems and considering the fact that there has been no study to date about the effect of fennel on menstrual bleeding and duration of menstrual bleeding through systematic review, the present study was conducted to determine the effect of fennel on the amount (primary outcome) and duration of menstrual bleeding and its side-effects (secondary outcomes)...
March 2, 2018: Journal of Complementary & Integrative Medicine
U Zastrau, C Rödel, M Nakatsutsumi, T Feigl, K Appel, B Chen, T Döppner, T Fennel, T Fiedler, L B Fletcher, E Förster, E Gamboa, D O Gericke, S Göde, C Grote-Fortmann, V Hilbert, L Kazak, T Laarmann, H J Lee, P Mabey, F Martinez, K-H Meiwes-Broer, H Pauer, M Perske, A Przystawik, S Roling, S Skruszewicz, M Shihab, J Tiggesbäumker, S Toleikis, M Wünsche, H Zacharias, S H Glenzer, G Gregori
We present an extreme ultraviolet (EUV) microscope using a Schwarzschild objective which is optimized for single-shot sub-micrometer imaging of laser-plasma targets. The microscope has been designed and constructed for imaging the scattering from an EUV-heated solid-density hydrogen jet. Imaging of a cryogenic hydrogen target was demonstrated using single pulses of the free-electron laser in Hamburg (FLASH) free-electron laser at a wavelength of 13.5 nm. In a single exposure, we observe a hydrogen jet with ice fragments with a spatial resolution in the sub-micrometer range...
February 2018: Review of Scientific Instruments
Franziska Fennel, Jana Gershberg, Matthias Stolte, Frank Würthner
Constituting an intermediate state of matter between molecules and solid state materials, dye aggregates can give important insights into functional properties. Despite the importance of fluorescence for many applications, it turns out that the conventional methods for quantum yield determination are not applicable to dye aggregates and so far no method has been introduced for the accurate determination of the fluorescence quantum yields of dye aggregates. Here we suggest two measurement routines for the quantum yield determination of strongly absorbing dye aggregates...
March 1, 2018: Physical Chemistry Chemical Physics: PCCP
Abigail Laman-Maharg, Alexia V Williams, Mikaela D Zufelt, Vanessa A Minie, Stephanie Ramos-Maciel, Rebecca Hao, Evelyn Ordoñes Sanchez, Tiffany Copeland, Jill L Silverman, Angelina Leigh, Rodney Snyder, F Ivy Carroll, Timothy R Fennell, Brian C Trainor
There is growing evidence that kappa opioid receptor (KOR) antagonists could be a useful class of therapeutics for treating depression and anxiety. However, the overwhelming majority of preclinical investigations examining the behavioral effects of KOR antagonists have been in male rodents. Here, we examined the effects of the long-acting KOR antagonist nor-binaltophimine (norBNI) on immobility in the forced swim test in males and females of two different rodent species (C57Bl/6J and California mice). Consistent with previous reports, norBNI (10 mg/kg) decreased immobility in the forced swim test for male C57Bl/6J and California mice...
2018: Frontiers in Pharmacology
Juan Xie, Anjun Ma, Anne Fennell, Qin Ma, Jing Zhao
Biclustering is a powerful data mining technique that allows clustering of rows and columns, simultaneously, in a matrix-format data set. It was first applied to gene expression data in 2000, aiming to identify co-expressed genes under a subset of all the conditions/samples. During the past 17 years, tens of biclustering algorithms and tools have been developed to enhance the ability to make sense out of large data sets generated in the wake of high-throughput omics technologies. These algorithms and tools have been applied to a wide variety of data types, including but not limited to, genomes, transcriptomes, exomes, epigenomes, phenomes and pharmacogenomes...
February 27, 2018: Briefings in Bioinformatics
Fareeduddin Quadri Syed, Ayman I Elkady, Furkhan Ahmed Mohammed, Muqtadir Baig Mirza, Khalid Rehman Hakeem, Saleh Alkarim
ETHNOPHARMACOLOGICAL RELEVANCE: Foeniculum vulgare Mill. (Fennel) is one of the most common herbs used in alternative medicines for its varied range of bioactivity. In Ecuador (South America), use of fennel in traditional cancer treatment is on record. AIM OF THE STUDY: The objective of the present study was to demonstrate the anti-proliferative and apoptotic effect of chloroform fraction of fennel (CFF) in MCF-7 cells. MATERIALS AND METHODS: Anti-proliferative assay (MTT assay) and colony formation assay was performed to study the growth inhibitory effect of CFF...
February 20, 2018: Journal of Ethnopharmacology
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