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https://www.readbyqxmd.com/read/29454611/taste-receptor-plasticity-in-relation-to-feeding-history-in-two-congeneric-species-of-papilionidae-lepidoptera
#1
Giorgia Sollai, Maurizio Biolchini, Roberto Crnjar
In the peripheral taste system of insects, the responsiveness of gustatory receptor neurons (GRNs) depends on several factors, such as larval instar, feeding history, physiological state and time of day. To study the role of the feeding history, the spike activity of the maxillary taste chemosensilla in the larvae of two related species of Lepidoptera (Papilio machaon L. and Papilio hospiton Géné) raised on different host plants, was recorded with electrophysiological techniques after stimulation with simple stimuli (sugars, bitters and inorganic salt) and host plant saps, with the aim of cross-comparing their response patterns and evaluating any effects of different feeding histories...
February 15, 2018: Journal of Insect Physiology
https://www.readbyqxmd.com/read/29451985/a-comparison-of-barriers-to-accessing-services-for-mental-and-physical-health-conditions-in-a-sample-of-rural-australian-adults
#2
Kate Fennell, Melissa Hull, Martin Jones, James Dollman
INTRODUCTION: The prevalence of chronic disease, mortality and suicide rates is higher in rural Australia than in urban centres. Understanding rural Australians' barriers to accessing health services requires urgent attention. The purpose of this study was to compare barriers to help-seeking for physical and mental health issues among rural South Australian adults. METHODS: A total of 409 people from three rural and remote regions in South Australia completed a computer-assisted telephone interview...
February 2018: Rural and Remote Health
https://www.readbyqxmd.com/read/29449282/a-patient-dose-reduction-technique-for-neuroendovascular-image-guided-interventions-image-quality-comparison-study
#3
A Sonig, S V Setlur Nagesh, V S Fennell, S Gandhi, L Rangel-Castilla, C N Ionita, K V Snyder, L N Hopkins, D R Bednarek, S Rudin, A H Siddiqui, E I Levy
BACKGROUND AND PURPOSE: The ROI-dose-reduced intervention technique represents an extension of ROI fluoroscopy combining x-ray entrance skin dose reduction with spatially different recursive temporal filtering to reduce excessive image noise in the dose-reduced periphery in real-time. The aim of our study was to compare the image quality of simulated neurointerventions with regular and reduced radiation doses using a standard flat panel detector system. MATERIALS AND METHODS: Ten 3D-printed intracranial aneurysm models were generated on the basis of a single patient vasculature derived from intracranial DSA and CTA...
February 15, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29444986/british-thoracic-society-guideline-for-the-investigation-and-management-of-malignant-pleural-mesothelioma
#4
Ian Woolhouse, Lesley Bishop, Liz Darlison, Duneesha De Fonseka, Anthony Edey, John Edwards, Corinne Faivre-Finn, Dean A Fennell, Steve Holmes, Keith M Kerr, Apostolos Nakas, Tim Peel, Najib M Rahman, Mark Slade, Jeremy Steele, Selina Tsim, Nick A Maskell
No abstract text is available yet for this article.
March 2018: Thorax
https://www.readbyqxmd.com/read/29444953/staphylococcal-osteomyelitis-disease-progression-treatment-challenges-and-future-directions
#5
REVIEW
Nicola Kavanagh, Emily J Ryan, Amro Widaa, Gillian Sexton, Jerome Fennell, Sadhbh O'Rourke, Kevin C Cahill, Cathal J Kearney, Fergal J O'Brien, Steven W Kerrigan
Osteomyelitis is an inflammatory bone disease that is caused by an infecting microorganism and leads to progressive bone destruction and loss. The most common causative species are the usually commensal staphylococci, with Staphylococcus aureus and Staphylococcus epidermidis responsible for the majority of cases. Staphylococcal infections are becoming an increasing global concern, partially due to the resistance mechanisms developed by staphylococci to evade the host immune system and antibiotic treatment. In addition to the ability of staphylococci to withstand treatment, surgical intervention in an effort to remove necrotic and infected bone further exacerbates patient impairment...
April 2018: Clinical Microbiology Reviews
https://www.readbyqxmd.com/read/29423054/copy-number-profiles-of-paired-primary-and-metastatic-colorectal-cancers
#6
Futoshi Kawamata, Ann-Marie Patch, Katia Nones, Catherine Bond, Diane McKeone, Sally-Ann Pearson, Shigenori Homma, Cheng Liu, Lochlan Fennell, Troy Dumenil, Gunter Hartel, Nozomi Kobayasi, Hideki Yokoo, Moto Fukai, Hiroshi Nishihara, Toshiya Kamiyama, Matthew E Burge, Christos S Karapetis, Akinobu Taketomi, Barbara Leggett, Nicola Waddell, Vicki Whitehall
Liver metastasis is the major cause of death following a diagnosis of colorectal cancer (CRC). In this study, we compared the copy number profiles of paired primary and liver metastatic CRC to better understand how the genomic structure of primary CRC differs from the metastasis. Paired primary and metastatic tumors from 16 patients and their adjacent normal tissue samples were analyzed using single nucleotide polymorphism arrays. Genome-wide chromosomal copy number alterations were assessed, with particular attention to 188 genes known to be somatically altered in CRC and 24 genes that are clinically actionable in CRC...
January 9, 2018: Oncotarget
https://www.readbyqxmd.com/read/29416048/publisher-correction-nanoplasmonic-electron-acceleration-by-attosecond-controlled-forward-rescattering-in-silver-clusters
#7
Johannes Passig, Sergey Zherebtsov, Robert Irsig, Mathias Arbeiter, Christian Peltz, Sebastian Göde, Slawomir Skruszewicz, Karl-Heinz Meiwes-Broer, Josef Tiggesbäumker, Matthias F Kling, Thomas Fennel
The original PDF version of this Article contained an error in Equation 1. The original HTML version of this Article contained errors in Equation 2 and Equation 4. These errors have now been corrected in both the PDF and the HTML versions of the Article.
February 7, 2018: Nature Communications
https://www.readbyqxmd.com/read/29403626/a-review-of-effective-herbal-medicines-in-controlling-menopausal-symptoms
#8
REVIEW
Rahele Kargozar, Hoda Azizi, Roshanak Salari
Background: Acute menopausal syndrome especially hot flashes, is one of the most common gynecological problems during menopause. Due to the side effects of hormone therapy, herbal and complementary medicines are always of immense interest to people in the treatment and management of the symptoms and complications of menopause. Objective: The aim of this study was to investigate the mechanisms and effects of medicinal plants employed in the treatment of menopausal symptoms...
November 2017: Electronic Physician
https://www.readbyqxmd.com/read/29385628/evaluating-in-vitro-in-vivo-extrapolation-of-toxicokinetics
#9
John F Wambaugh, Michael F Hughes, Caroline L Ring, Denise K MacMillan, Jermaine Ford, Timothy R Fennell, Sherry R Black, Rodney W Snyder, Nisha S Sipes, Barbara Wetmore, Joost Westerhout, R Woodrow Setzer, Robert Pearce, Jane-Ellen Simmons, Russell S Thomas
Prioritizing the risk posed by thousands of chemicals potentially present in the environment requires exposure, toxicity, and toxicokinetic (TK) data, which are often unavailable. Relatively high throughput, in vitro TK (HTTK) assays and in vitro-to-in vivo extrapolation (IVIVE) methods have been developed to predict TK, but most of the in vivo TK data available to benchmark these methods are from pharmaceuticals. Here we report on new, in vivo rat TK experiments for 26 non-pharmaceutical chemicals with environmental-relevance...
January 27, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29378632/the-effects-of-a-12-week-worksite-physical-activity-intervention-on-anthropometric-indices-blood-pressure-indices-and-plasma-biomarkers-of-cardiovascular-disease-risk-among-university-employees
#10
Duane B Corbett, Curtis Fennell, Kylene Peroutky, J Derek Kingsley, Ellen L Glickman
BACKGROUND: To determine the effectiveness of a low-cost 12-week worksite physical activity intervention targeting a goal of 10,000 steps per day on reducing anthropometric indices, blood pressure indices, and plasma biomarkers of cardiovascular disease (CVD) risk among the employees of a major university. METHODS: Fifty university employees (n = 43 female, n = 7 male; mean age = 48 ± 10 years) participated in the 12-week physical activity intervention (60 min, 3 day/week)...
January 29, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29360107/erratum-sequence-data-and-association-statistics-from-12-940-type-2-diabetes-cases-and-controls
#11
Jason Flannick, Christian Fuchsberger, Anubha Mahajan, Tanya M Teslovich, Vineeta Agarwala, Kyle J Gaulton, Lizz Caulkins, Ryan Koesterer, Clement Ma, Loukas Moutsianas, Davis J McCarthy, Manuel A Rivas, John R B Perry, Xueling Sim, Thomas W Blackwell, Neil R Robertson, N William Rayner, Pablo Cingolani, Adam E Locke, Juan Fernandez Tajes, Heather M Highland, Josee Dupuis, Peter S Chines, Cecilia M Lindgren, Christopher Hartl, Anne U Jackson, Han Chen, Jeroen R Huyghe, Martijn van de Bunt, Richard D Pearson, Ashish Kumar, Martina Müller-Nurasyid, Niels Grarup, Heather M Stringham, Eric R Gamazon, Jaehoon Lee, Yuhui Chen, Robert A Scott, Jennifer E Below, Peng Chen, Jinyan Huang, Min Jin Go, Michael L Stitzel, Dorota Pasko, Stephen C J Parker, Tibor V Varga, Todd Green, Nicola L Beer, Aaron G Day-Williams, Teresa Ferreira, Tasha Fingerlin, Momoko Horikoshi, Cheng Hu, Iksoo Huh, Mohammad Kamran Ikram, Bong-Jo Kim, Yongkang Kim, Young Jin Kim, Min-Seok Kwon, Juyoung Lee, Selyeong Lee, Keng-Han Lin, Taylor J Maxwell, Yoshihiko Nagai, Xu Wang, Ryan P Welch, Joon Yoon, Weihua Zhang, Nir Barzilai, Benjamin F Voight, Bok-Ghee Han, Christopher P Jenkinson, Teemu Kuulasmaa, Johanna Kuusisto, Alisa Manning, Maggie C Y Ng, Nicholette D Palmer, Beverley Balkau, Alena Stančáková, Hanna E Abboud, Heiner Boeing, Vilmantas Giedraitis, Dorairaj Prabhakaran, Omri Gottesman, James Scott, Jason Carey, Phoenix Kwan, George Grant, Joshua D Smith, Benjamin M Neale, Shaun Purcell, Adam S Butterworth, Joanna M M Howson, Heung Man Lee, Yingchang Lu, Soo-Heon Kwak, Wei Zhao, John Danesh, Vincent K L Lam, Kyong Soo Park, Danish Saleheen, Wing Yee So, Claudia H T Tam, Uzma Afzal, David Aguilar, Rector Arya, Tin Aung, Edmund Chan, Carmen Navarro, Ching-Yu Cheng, Domenico Palli, Adolfo Correa, Joanne E Curran, Dennis Rybin, Vidya S Farook, Sharon P Fowler, Barry I Freedman, Michael Griswold, Daniel Esten Hale, Pamela J Hicks, Chiea-Chuen Khor, Satish Kumar, Benjamin Lehne, Dorothée Thuillier, Wei Yen Lim, Jianjun Liu, Marie Loh, Solomon K Musani, Sobha Puppala, William R Scott, Loïc Yengo, Sian-Tsung Tan, Herman A Taylor, Farook Thameem, Gregory Wilson, Tien Yin Wong, Pål Rasmus Njølstad, Jonathan C Levy, Massimo Mangino, Lori L Bonnycastle, Thomas Schwarzmayr, João Fadista, Gabriela L Surdulescu, Christian Herder, Christopher J Groves, Thomas Wieland, Jette Bork-Jensen, Ivan Brandslund, Cramer Christensen, Heikki A Koistinen, Alex S F Doney, Leena Kinnunen, Tõnu Esko, Andrew J Farmer, Liisa Hakaste, Dylan Hodgkiss, Jasmina Kravic, Valeri Lyssenko, Mette Hollensted, Marit E Jørgensen, Torben Jørgensen, Claes Ladenvall, Johanne Marie Justesen, Annemari Käräjämäki, Jennifer Kriebel, Wolfgang Rathmann, Lars Lannfelt, Torsten Lauritzen, Narisu Narisu, Allan Linneberg, Olle Melander, Lili Milani, Matt Neville, Marju Orho-Melander, Lu Qi, Qibin Qi, Michael Roden, Olov Rolandsson, Amy Swift, Anders H Rosengren, Kathleen Stirrups, Andrew R Wood, Evelin Mihailov, Christine Blancher, Mauricio O Carneiro, Jared Maguire, Ryan Poplin, Khalid Shakir, Timothy Fennell, Mark DePristo, Martin Hrabé de Angelis, Panos Deloukas, Anette P Gjesing, Goo Jun, Peter Nilsson, Jacquelyn Murphy, Robert Onofrio, Barbara Thorand, Torben Hansen, Christa Meisinger, Frank B Hu, Bo Isomaa, Fredrik Karpe, Liming Liang, Annette Peters, Cornelia Huth, Stephen P O'Rahilly, Colin N A Palmer, Oluf Pedersen, Rainer Rauramaa, Jaakko Tuomilehto, Veikko Salomaa, Richard M Watanabe, Ann-Christine Syvänen, Richard N Bergman, Dwaipayan Bharadwaj, Erwin P Bottinger, Yoon Shin Cho, Giriraj R Chandak, Juliana C N Chan, Kee Seng Chia, Mark J Daly, Shah B Ebrahim, Claudia Langenberg, Paul Elliott, Kathleen A Jablonski, Donna M Lehman, Weiping Jia, Ronald C W Ma, Toni I Pollin, Manjinder Sandhu, Nikhil Tandon, Philippe Froguel, Inês Barroso, Yik Ying Teo, Eleftheria Zeggini, Ruth J F Loos, Kerrin S Small, Janina S Ried, Ralph A DeFronzo, Harald Grallert, Benjamin Glaser, Andres Metspalu, Nicholas J Wareham, Mark Walker, Eric Banks, Christian Gieger, Erik Ingelsson, Hae Kyung Im, Thomas Illig, Paul W Franks, Gemma Buck, Joseph Trakalo, David Buck, Inga Prokopenko, Reedik Mägi, Lars Lind, Yossi Farjoun, Katharine R Owen, Anna L Gloyn, Konstantin Strauch, Tiinamaija Tuomi, Jaspal Singh Kooner, Jong-Young Lee, Taesung Park, Peter Donnelly, Andrew D Morris, Andrew T Hattersley, Donald W Bowden, Francis S Collins, Gil Atzmon, John C Chambers, Timothy D Spector, Markku Laakso, Tim M Strom, Graeme I Bell, John Blangero, Ravindranath Duggirala, E Shyong Tai, Gilean McVean, Craig L Hanis, James G Wilson, Mark Seielstad, Timothy M Frayling, James B Meigs, Nancy J Cox, Rob Sladek, Eric S Lander, Stacey Gabriel, Karen L Mohlke, Thomas Meitinger, Leif Groop, Goncalo Abecasis, Laura J Scott, Andrew P Morris, Hyun Min Kang, David Altshuler, Noël P Burtt, Jose C Florez, Michael Boehnke, Mark I McCarthy
This corrects the article DOI: 10.1038/sdata.2017.179.
January 23, 2018: Scientific Data
https://www.readbyqxmd.com/read/29354616/the-effect-of-foeniculum-vulgare-fennel-on-body-composition-in-postmenopausal-women-with-excess-weight-a-double-blind-randomized-placebo-controlled-trial
#12
Nafiseh Saghafi, Masumeh Ghazanfarpour, Talat Khadivzadeh, Masoudeh Babakhanian, Maliheh Afiat
Objectives: The goal of this study was to evaluate the effect of fennel on body composition. Methods: This study is a secondary analysis of a double-blind, randomized, placebo-controlled trial. Fifty-four out of 60 patients were able to successfully complete the original study. Seven out of 54 patients were excluded because they were not overweight and obese. Thus, 47 women were included in this secondary analysis. Of these 47 women, 22 were in the fennel group and 25 were in placebo group...
December 2017: Journal of Menopausal Medicine
https://www.readbyqxmd.com/read/29354615/effect-of-phytoestrogen-on-depression-and-anxiety-in-menopausal-women-a-systematic-review
#13
Abolfazl Fattah
Objectives: In this systematic review, the effectiveness of herbal medicines in improving depression and anxiety in menopausal women was assessed. Methods: Three following databases were individually searched: MEDLINE (1966-March 2017), SCOPUS (1990-March 2017), and the Cochrane Library (Cochrane Central Register of Controlled Trials; 2017). Results: A total of 9 trials were included in this systematic review. Overall, soy was found to have a beneficial effect...
December 2017: Journal of Menopausal Medicine
https://www.readbyqxmd.com/read/29352061/what-to-do-about-fibrin-rich-tough-clots-comparing-the-solitaire-stent-retriever-with-a-novel-geometric-clot-extractor-in-an-in-vitro-stroke-model
#14
Vernard S Fennell, Swetadri Vasan Setlur Nagesh, Karen M Meess, Liza Gutierrez, Rhys H James, Michael E Springer, Adnan H Siddiqui
BACKGROUND: Despite advances in revascularization tools for large vessel occlusion presenting as acute ischemic stroke, a significant subset of clots remain recalcitrant to current strategies. We assessed the effectiveness of a novel thrombectomy device that was specifically designed to retrieve resistant fibrin rich clots, the geometric clot extractor (GCE; Neuravi, Galway, Ireland), in an in vitro cerebrovascular occlusion stroke model. METHODS: After introducing fibrin rich clot analogues into the middle cerebral artery of the model, we compared the rates of recanalization between GCE and Solitaire flow restoration stent retriever (SR; Medtronic, Minneapolis, Minnesota, USA; control group) cases...
January 19, 2018: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29345980/society-of-biomolecular-imaging-and-informatics-high-content-screening-high-content-analysis-emerging-technologies-in-biological-models-when-and-why
#15
Ann F Hoffman, John Nolan, David F Gebhard, Debra Nickischer, Wienand Omta, Sam Cooper, Sharon Presnell, Judi Wardwell-Swanson, Myles Fennell
No abstract text is available yet for this article.
January 2018: Assay and Drug Development Technologies
https://www.readbyqxmd.com/read/29345617/loss-of-functional-bap1-augments-sensitivity-to-trail-in-cancer-cells
#16
Krishna Kalyan Kolluri, Constantine Alifrangis, Neelam Kumar, Yuki Ishii, Stacey Price, Magali Michaut, Steven Williams, Syd Barthorpe, Howard Lightfoot, Sara Busacca, Annabel Sharkey, Zhenqiang Yuan, Elizabeth K Sage, Sabarinath Vallath, John Le Quesne, David A Tice, Doraid Alrifai, Sylvia von Karstedt, Antonella Montinaro, Naomi Guppy, David A Waller, Apostolos Nakas, Robert Good, Alan Holmes, Henning Walczak, Dean A Fennell, Mathew Garnett, Francesco Iorio, Lodewyk Wessels, Ultan McDermott, Samuel M Janes
Malignant mesothelioma (MM) is poorly responsive to systemic cytotoxic chemotherapy and invariably fatal. Here we describe a screen of 94 drugs in 15 exome-sequenced MM lines and the discovery of a subset defined by loss of function of the nuclear deubiquitinase BRCA associated protein-1 (BAP1) that demonstrate heightened sensitivity to TRAIL (tumour necrosis factor-related apoptosis-inducing ligand). This association is observed across human early passage MM cultures, mouse xenografts and human tumour explants...
January 18, 2018: ELife
https://www.readbyqxmd.com/read/29343235/comparison-of-three-assembly-strategies-for-a-heterozygous-seedless-grapevine-genome-assembly
#17
Sagar Patel, Zhixiu Lu, Xiaozhu Jin, Padmapriya Swaminathan, Erliang Zeng, Anne Y Fennell
BACKGROUND: De novo heterozygous assembly is an ongoing challenge requiring improved assembly approaches. In this study, three strategies were used to develop de novo Vitis vinifera 'Sultanina' genome assemblies for comparison with the inbred V. vinifera (PN40024 12X.v2) reference genome and a published Sultanina ALLPATHS-LG assembly (AP). The strategies were: 1) a default PLATANUS assembly (PLAT_d) for direct comparison with AP assembly, 2) an iterative merging strategy using METASSEMBLER to combine PLAT_d and AP assemblies (MERGE) and 3) PLATANUS parameter modifications plus GapCloser (PLAT*_GC)...
January 17, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29335531/publisher-correction-coherent-diffractive-imaging-of-single-helium-nanodroplets-with-a-high-harmonic-generation-source
#18
Daniela Rupp, Nils Monserud, Bruno Langbehn, Mario Sauppe, Julian Zimmermann, Yevheniy Ovcharenko, Thomas Möller, Fabio Frassetto, Luca Poletto, Andrea Trabattoni, Francesca Calegari, Mauro Nisoli, Katharina Sander, Christian Peltz, Marc J Vrakking, Thomas Fennel, Arnaud Rouzée
In the original version of this Article, the affiliation for Luca Poletto was incorrectly given as 'European XFEL GmbH, Holzkoppel 4, 22869 Schenefeld, Hamburg, Germany', instead of the correct 'CNR, Istituto di Fotonica e Nanotecnologie Padova, Via Trasea 7, 35131 Padova, Italy'. This has now been corrected in both the PDF and HTML versions of the Article.
January 16, 2018: Nature Communications
https://www.readbyqxmd.com/read/29310613/efficacy-of-a-telephone-outcall-program-to-reduce-caregiver-burden-among-caregivers-of-cancer-patients-protect-a-randomised-controlled-trial
#19
Leila Heckel, Kate M Fennell, John Reynolds, Anna Boltong, Mari Botti, Richard H Osborne, Cathrine Mihalopoulos, Jacquie Chirgwin, Melinda Williams, Cadeyrn J Gaskin, David M Ashley, Patricia M Livingston
BACKGROUND: Informal caregivers provide extended support to people with cancer but they receive little support from the health care system to assist them in their caring role. The aim of this single-blind, multi-centre, randomised controlled trial was to test the efficacy of a telephone outcall program to reduce caregiver burden and unmet needs, and improve psychological well-being among cancer caregivers, as well as evaluating the potential impact on patient outcomes. METHODS: Cancer patient/caregiver dyads (N = 216) were randomised to a telephone outcall program (n = 108) or attention control group (n = 108)...
January 8, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29304767/mlh1-93%C3%A2-g-a-polymorphism-is-associated-with-mlh1-promoter-methylation-and-protein-loss-in-dysplastic-sessile-serrated-adenomas-with-brafv600e-mutation
#20
Lochlan J Fennell, Saara Jamieson, Diane McKeone, Tracie Corish, Megan Rohdmann, Tori Furner, Mark Bettington, Cheng Liu, Futoshi Kawamata, Catherine Bond, Jolieke Van De Pols, Barbara Leggett, Vicki Whitehall
BACKGROUND: Sessile serrated adenomas with BRAF mutation progress rapidly to cancer following the development of dysplasia (SSAD). Approximately 75% of SSADs methylate the mismatch repair gene MLH1, develop mismatch repair deficiency and the resultant cancers have a good prognosis. The remaining SSADs and BRAF mutant traditional serrated adenomas (TSA) develop into microsatellite stable cancers with a poor prognosis. The reason for this dichotomy is unknown. In this study, we assessed the genotypic frequency of the MLH1-93 polymorphism rs1800734 in SSADs and TSAs to determine if the uncommon variant A allele predisposes to MLH1 promoter hypermethylation...
January 5, 2018: BMC Cancer
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