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https://www.readbyqxmd.com/read/28320714/variability-in-trough-total-and-unbound-teicoplanin-concentrations-and-achievement-of-therapeutic-drug-monitoring-targets-in-adult-patients-with-haematological-malignancy
#1
Catherine J Byrne, Jason A Roberts, Brett McWhinney, Jerome P Fennell, Philomena O'Byrne, Evelyn Deasy, Sean Egan, Ronan Desmond, Helen Enright, Sheila A Ryder, Deirdre M D'Arcy, Johnny McHugh
Objectives: To explore the following aspects of teicoplanin use in patients with haematological malignancy: early attainment of target trough concentrations with current high dose teicoplanin regimens; variability in unbound teicoplanin fractions; factors associated with observed total and unbound trough concentrations; efficacy and toxicity; and renal function estimation.Methods: This was a single-centre, prospective study. Trough samples were taken on Days 3, 4, 7 and 10. Total and unbound teicoplanin concentrations were determined using validated HPLC methods...
March 20, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28317747/physicochemical-characteristics-and-pollen-spectrum-of-monofloral-honeys-from-tenerife-spain
#2
Antonio Bentabol Manzanares, Zoa Hernández García, Beatriz Rodríguez Galdón, Elena M Rodríguez-Rodríguez, Carlos Díaz Romero
Physicochemical parameters, sugar composition and botanical origin were determined in four monofloral honeys, chestnut, fennel, tajinaste, and Teide broom honeys, abundantly produced in Tenerife Island. All the parameters were within the established intervals in Europe for each type of honey. Large differences between the four monofloral honeys were observed, being the chestnut honeys with most of differential characteristics. Linear discriminant analysis on the physicochemical parameters and sugar composition allows to distinguishing the four types of honeys analysed...
August 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28288420/molecular-characteristics-of-water-extractable-organic-matter-from-different-composted-biomasses-and-their-effects-on-seed-germination-and-early-growth-of-maize
#3
Hiarhi Monda, Vincenza Cozzolino, Giovanni Vinci, Riccardo Spaccini, Alessandro Piccolo
Four water extractable organic matter (WEOM) were obtained from composts made out of residues of: 1. artichoke (C-CYN), 2. artichoke/fennel (C-CYNF), 3. tomato/woodchips (C-TOM), 4. Municipal solid waste (C-MSW), and their bioactivity was tested for maize seed germination and maize seedling growth. The molecular properties of both original composts and their WEOM were characterized by spectroscopic ((13)C-CPMAS- and (1)H NMR, FTIR-ATR), thermochemolysis-GC/MS, and thermal methods (TGA, DSC). While all WEOM had significant effects on plant growth, CYN-WEOM was the only material that concomitantly increased germination rate and primary and lateral root length of maize seedlings...
March 10, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28280570/a-method-for-detecting-characteristic-patterns-in-social-interactions-with-an-application-to-handover-interactions
#4
Nikolai W F Bode, Andrew Sutton, Lindsey Lacey, John G Fennell, Ute Leonards
Social interactions are a defining behavioural trait of social animals. Discovering characteristic patterns in the display of such behaviour is one of the fundamental endeavours in behavioural biology and psychology, as this promises to facilitate the general understanding, classification, prediction and even automation of social interactions. We present a novel approach to study characteristic patterns, including both sequential and synchronous actions in social interactions. The key concept in our analysis is to represent social interactions as sequences of behavioural states and to focus on changes in behavioural states shown by individuals rather than on the duration for which they are displayed...
January 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28267636/population-pharmacokinetics-of-teicoplanin-and-attainment-of-pharmacokinetic-pharmacodynamic-targets-in-adult-patients-with-haematological-malignancy
#5
Catherine J Byrne, Jason A Roberts, Brett McWhinney, Sheila A Ryder, Jerome P Fennell, Philomena O'Byrne, Evelyn Deasy, Sean Egan, Ronan Desmond, Helen Enright, Deirdre M D'Arcy, Johnny McHugh
OBJECTIVES: To describe the population pharmacokinetics of teicoplanin in adult haematological malignancy patients receiving higher than standard doses and to perform Monte Carlo simulations to determine dosing regimens associated with optimal teicoplanin concentrations. METHODS: This was a hospital-based clinical trial (EudraCT 2013-004535-72). Nine blood samples were collected on Day 3, plus single trough samples on Days 7 and 10, and 24 and 48 h post last dose...
March 3, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28239718/solvent-control-of-intramolecular-proton-transfer-is-4-hydroxy-3-piperidin-1-ylmethyl-1-naphthaldehyde-a-proton-crane
#6
Y Manolova, H Marciniak, S Tschierlei, F Fennel, F S Kamounah, S Lochbrunner, L Antonov
The solvent dependent excited state dynamics of 4-hydroxy-3-(piperidin-1-ylmethyl)-1-naphthaldehyde (compound 2), a candidate for a molecular switch based on intramolecular proton transfer, was investigated by ultrafast spectroscopy and quantum-chemical calculations. In acetonitrile a mixture of molecules in the enol and zwitterionic proton transfer (PT) form exists in the ground state. However, the zwitterion is the energetically favored one in the electronically excited state. Optical excitation of the enol form results in intramolecular proton transfer and formation of the PT form within 1...
February 27, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28231113/chemical-composition-antioxidant-and-antimicrobial-activity-of-essential-oils-from-organic-fennel-parsley-and-lavender-from-spain
#7
Irene Marín, Estrella Sayas-Barberá, Manuel Viuda-Martos, Casilda Navarro, Esther Sendra
The aim of this work was to (i) determine the chemical composition of the essential oils of three spices widely cultivated in Spain from organic growth: Foeniculum vulgare, Petroselium crispum, and Lavandula officinalis; (ii) determine the total phenolic content; (iii) determine the antioxidant activity of the essentials oils by means of three different antioxidant tests and (iv) determine the effectiveness of these essentials oils on the inhibition of Listeria innocua CECT 910 and Pseudomonas fluorescens CECT 844...
March 4, 2016: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28215625/identification-badge-lanyards-as-infection-control-risk-a-cross-sectional-observation-study-with-epidemiological-analysis
#8
C M Murphy, F Di Ruscio, M Lynskey, J Collins, E McCullough, R Cosgrave, D McDonnell, J Fennell
Staphylococcus aureus cultures from name badge lanyards were phenotypically and genotypically indistinguishable from the wearer's nasal carrier strains by pulsed-field gel electrophoresis and antibiogram. Lanyards had a mean age of 22 months and hygiene was poor with only 9% ever having been laundered. Molecular analysis showed that 26% of S. aureus nasal carriers shared an indistinguishable strain on their lanyard. Lanyards should not be recommended for staff in frontline clinical care.
January 21, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28208803/barriers-to-seeking-help-for-skin-cancer-detection-in-rural-australia
#9
Kate M Fennell, Kimberley Martin, Carlene J Wilson, Camilla Trenerry, Greg Sharplin, James Dollman
This study explores rural South Australians' barriers to help-seeking for skin cancer detection. A total of 201 randomly selected rural adults (18-94 years, 66% female) were presented with a skin-cancer-related scenario via telephone and were asked the extent to which various barriers would impede their help-seeking, based on an amended version of the Barriers to Help-Seeking Scale. Older (≥63 years) and less educated participants endorsed barriers more strongly than their younger, more educated counterparts in the following domains; "Concrete barriers and distrust of caregivers", "Emotional control", "Minimising problem and Normalisation", "Need for control and self-reliance" (every domain other than "Privacy")...
February 13, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/28181494/microenvironment-derived-factors-driving-metastatic-plasticity-in-melanoma
#10
Isabella S Kim, Silja Heilmann, Emily R Kansler, Yan Zhang, Milena Zimmer, Kajan Ratnakumar, Robert L Bowman, Theresa Simon-Vermot, Myles Fennell, Ralph Garippa, Liang Lu, William Lee, Travis Hollmann, Joao B Xavier, Richard M White
Cellular plasticity is a state in which cancer cells exist along a reversible phenotypic spectrum, and underlies key traits such as drug resistance and metastasis. Melanoma plasticity is linked to phenotype switching, where the microenvironment induces switches between invasive/MITF(LO) versus proliferative/MITF(HI) states. Since MITF also induces pigmentation, we hypothesize that macrometastatic success should be favoured by microenvironments that induce a MITF(HI)/differentiated/proliferative state. Zebrafish imaging demonstrates that after extravasation, melanoma cells become pigmented and enact a gene expression program of melanocyte differentiation...
February 9, 2017: Nature Communications
https://www.readbyqxmd.com/read/28172469/qubic-a-bioconductor-package-for-qualitative-biclustering-analysis-of-gene-co-expression-data
#11
Yu Zhang, Juan Xie, Jinyu Yang, Anne Fennell, Chi Zhang, Qin Ma
No abstract text is available yet for this article.
February 1, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28127770/the-epicenter-of-effectiveness-and-efficiency-in-health-care-delivery-the-evolving-u-s-health-workforce
#12
Michelle M Washko, Mary L Fennell
No abstract text is available yet for this article.
February 2017: Health Services Research
https://www.readbyqxmd.com/read/28125179/an-approach-to-optimise-therapeutic-vancomycin-dosage-in-a-haemodialysis-population
#13
H Gunning, G Taylor, A Smyth, G Mellotte, J Fennell, P Murphy, P Lavin, C Wall
Haemodialysis patients are at risk of gram-positive bacteraemia and commonly require intravenous vancomycin. Intravenously administered vancomycin is primarily excreted by the kidney and exhibits complex pharmacokinetics in haemodialysis patients; achieving therapeutic levels can be challenging. An audit in our unit showed current practises of vancomycin administration resulted in a high proportion of sub-therapeutic levels. A new protocol was developed with fixed weight-based loading and subsequent dosing guided by pre-dialysis levels, target levels were 10-20mg/L...
October 12, 2016: Irish Medical Journal
https://www.readbyqxmd.com/read/28124812/an-insight-on-salting-out-assisted-liquid-liquid-extraction-for-phytoanalysis
#14
Inês M Valente, Manuela M Moreira, Pâmela Neves, Thiago da Fé, Luís M Gonçalves, Paulo J Almeida, José A Rodrigues
INTRODUCTION: Salting-out assisted liquid-liquid extraction (SALLE) is a technique that, although simple and not requiring any complex equipment, is very powerful and versatile. It has obtained growing interest in bioanalysis particularly when combined with chromatographic techniques. OBJECTIVES: Herein, fennel seeds (Foeniculum vulgare Mill.) were used as a case-study to show the application of SALLE in phytochemical analysis. MATERIAL AND METHODS: SALLE combined with HPLC-UV-MS/MS and GC-MS...
January 26, 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28121459/development-of-sustainable-dye-adsorption-system-using-nutraceutical-industrial-fennel-seed-spent-studies-with-congo-red-dye
#15
Syed Noeman Taqui, Rosiyah Yahya, Aziz Hassan, Nayan Nayak, Akheel Ahmed Syed
Fennel seed spent (FSS) - an inexpensive nutraceutical industrial spent has been used as an efficient biosorbent for the removal of Congo Red (CR) from aqueous media. Results show that pH of 2 - 4 and temperature of 30°C was ideal for maximum adsorption. Based on regression fitting of the data it was determined that the SIPS isotherm (R(2) = 0.994, χ(2) = 0.5) adequately described the mechanism of adsorption, suggesting that the adsorption occurs in a homogeneous layer by layer with favourable interaction between layers...
January 25, 2017: International Journal of Phytoremediation
https://www.readbyqxmd.com/read/28107136/the-admin-effect-managing-the-orthodontic-patient-journey-to-ensure-patient-satisfaction-and-quality-of-care-practice-co-ordinators-isobel-fennell-suzi-rammell-and-jen-blakeman
#16
Isobel Fennell, Suzi Rammell, Jen Blakeman
No abstract text is available yet for this article.
November 1, 2016: Primary Dental Journal
https://www.readbyqxmd.com/read/28092461/sbi-2-hcs-hca-3d-imaging-best-practices-and-unmet-needs-colloquium
#17
Ann F Hoffman, Kaylene J Simpson, Peter Horvath, Carrie Lovitt, Serena Silver, Evan Easton, Daniel V LaBarbera, Melissa Mendez, Mark E Rothenberg, Jan Seldin, Judi Wardwell-Swanson, Myles Fennell
No abstract text is available yet for this article.
January 2017: Assay and Drug Development Technologies
https://www.readbyqxmd.com/read/28069152/use-of-the-distress-thermometer-in-a-cancer-helpline-context-can-it-detect-changes-in-distress-is-it-acceptable-to-nurses-and-callers-and-do-high-scores-lead-to-internal-referrals
#18
Karen Linehan, Kate M Fennell, Donna L Hughes, Carlene J Wilson
PURPOSE: To improve understanding about; (1) the validity of the Distress Thermometer (DT) as a measure of changes in distress after a cancer helpline call, (2) the impact of a helpline call on callers' distress, (3) caller and helpline nurses' comfort with use of the DT, and (4) the extent to which DT scores over the critical threshold, are associated with referral to internal support services for follow-up psychosocial care. METHODS: Callers (people diagnosed with cancer and their family/friends: N = 100) completed a questionnaire that included DT ratings (three time-points), the Depression Anxiety and Stress Scale-21 (DASS-21) and measures of comfort with the DT tool...
February 2017: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
https://www.readbyqxmd.com/read/28063268/evaluation-of-the-quality-of-herbal-teas-by-dart-tof-ms
#19
Jana Prchalová, František Kovařík, Aleš Rajchl
The paper focuses on the optimization, settings and validation of direct analysis in real time (DART) coupled with time of flight detector (TOF) when used for the evaluation of the quality of selected herbal teas (fennel, chamomile, nettle, linden, peppermint, thyme, lemon balm, marigold, sage, rose hip, St. John's Wort). The ionization mode, the optimal ionization temperature and the type of solvent for sample extraction were optimized. The characteristic compounds of the analysed herbal teas (glycosides, flavonoids, phenolic and terpenic substances, such as chamazulene, anethole, menthol, thymol, salviol, hypericin etc...
January 7, 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/28063208/effect-of-supplementation-of-calf-starter-with-fennel-powder-on-performance-weaning-age-and-fermentation-characteristics-in-holstein-dairy-calves
#20
S Saeedi, O Dayani, R Tahmasbi, A Khezri
The objective of this experiment was to investigate the effects on performance, weaning age and rumen fermentation characteristics in Holstein calves when fennel powder was added to their starter diets. Thirty Holstein calves with a mean birth weight 40 kg (SD = 0.5) were allocated randomly to one of the following experimental diets: (i) control (starter diet without fennel powder), (ii) starter diet containing 0.4% of fennel powder and (iii) starter diet containing 0.8% of fennel powder (DM basis). The effect of treatments on mean dry matter intake was significant (p < 0...
February 2017: Journal of Animal Physiology and Animal Nutrition
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