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https://www.readbyqxmd.com/read/27917696/levels-of-estragole-in-fennel-teas-marketed-in-austria-and-assessment-of-dietary-exposure
#1
Daniela Mihats, Leopold Pilsbacher, Robert Gabernig, Martin Routil, Martin Gutternigg, Reinhard Laenger
Levels of estragole in fennel teas (n = 42) on the Austrian market and the associated dietary exposure were assessed in this study. The estimated daily exposure from consumption of fennel teas ranged from 0.25 to 5.04 μg kg(-1) d(-1), 0.32 to 6.42 μg kg(-1) d(-1), and 0.15 to 2.93 μg kg(-1) d(-1) for children, women, and men, respectively. Daily estragole exposures for infants were 0.008-20.78 μg kg(-1) d(-1). Despite MOE values are above 10,000 for nearly half of the fennel teas analyzed, there are still MOEs below this value indicating a potential risk for human health and a priority for risk management...
December 5, 2016: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/27917288/towards-an-open-grapevine-information-system
#2
REVIEW
A-F Adam-Blondon, M Alaux, C Pommier, D Cantu, Z-M Cheng, G R Cramer, C Davies, S Delrot, L Deluc, G Di Gaspero, J Grimplet, A Fennell, J P Londo, P Kersey, F Mattivi, S Naithani, P Neveu, M Nikolski, M Pezzotti, B I Reisch, R Töpfer, M A Vivier, D Ware, H Quesneville
Viticulture, like other fields of agriculture, is currently facing important challenges that will be addressed only through sustained, dedicated and coordinated research. Although the methods used in biology have evolved tremendously in recent years and now involve the routine production of large data sets of varied nature, in many domains of study, including grapevine research, there is a need to improve the findability, accessibility, interoperability and reusability (FAIR-ness) of these data. Considering the heterogeneous nature of the data produced, the transnational nature of the scientific community and the experience gained elsewhere, we have formed an open working group, in the framework of the International Grapevine Genome Program (www...
2016: Horticulture Research
https://www.readbyqxmd.com/read/27910491/measurement-of-high-dynamic-range-x-ray-thomson-scattering-spectra-for-the-characterization-of-nano-plasmas-at-lcls
#3
M J MacDonald, T Gorkhover, B Bachmann, M Bucher, S Carron, R N Coffee, R P Drake, K R Ferguson, L B Fletcher, E J Gamboa, S H Glenzer, S Göde, S P Hau-Riege, D Kraus, J Krzywinski, A L Levitan, K-H Meiwes-Broer, C P O'Grady, T Osipov, T Pardini, C Peltz, S Skruszewicz, M Swiggers, C Bostedt, T Fennel, T Döppner
Atomic clusters can serve as ideal model systems for exploring ultrafast (∼100 fs) laser-driven ionization dynamics of dense matter on the nanometer scale. Resonant absorption of optical laser pulses enables heating to temperatures on the order of 1 keV at near solid density conditions. To date, direct probing of transient states of such nano-plasmas was limited to coherent x-ray imaging. Here we present the first measurement of spectrally resolved incoherent x-ray scattering from clusters, enabling measurements of transient temperature, densities, and ionization...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27905126/ameliorating-effects-of-fennel-and-cumin-extracts-on-sperm-quality-and-spermatogenic-cells-apoptosis-by-inducing-weight-loss-and-reducing-leptin-concentration-in-diet-induced-obese-rats
#4
R Nejatbakhsh, S Riyahi, A Farrokhi, S Rostamkhani, S Mahmazi, A Yazdinezhad, M Kazemi, S Shokri
This study was established a model of obesity to estimate the impact of fennel and cumin as anti-obesity extracts on body weight, body mass index (BMI), food consumption, leptin concentration, sperm quality and testis architecture to determine the reversibility of reproductive function of obese animals. Male rats were randomly assigned to either a normal or high-fat diet for 8 weeks. Then, we divided 56 adult rats into seven groups: control (CO); obesity (OB); fennel 100 and 200 mg/kg; cumin 50 and 100 mg/kg; and fennel 100 mg/kg plus cumin 50 mg/kg...
November 30, 2016: Andrologia
https://www.readbyqxmd.com/read/27884762/pleasantness-familiarity-and-identification-of-spice-odors-are-interrelated-and-enhanced-by-consumption-of-herbs-and-food-neophilia
#5
Antti Knaapila, Oskar Laaksonen, Markus Virtanen, Baoru Yang, Hanna Lagström, Mari Sandell
The primary dimension of odor is pleasantness, which is associated with a multitude of factors. We investigated how the pleasantness, familiarity, and identification of spice odors were associated with each other and with the use of the respective spice, overall use of herbs, and level of food neophobia. A total of 126 adults (93 women, 33 men; age 25-61 years, mean 39 years) rated the odors from 12 spices (oregano, anise, rosemary, mint, caraway, sage, thyme, cinnamon, fennel, marjoram, garlic, and clove) for pleasantness and familiarity, and completed a multiple-choice odor identification...
November 21, 2016: Appetite
https://www.readbyqxmd.com/read/27867796/highly-relativistic-radiation-belt-electron-acceleration-transport-and-loss-large-solar-storm-events-of-march-and-june-2015
#6
D N Baker, A N Jaynes, S G Kanekal, J C Foster, P J Erickson, J F Fennell, J B Blake, H Zhao, X Li, S R Elkington, M G Henderson, G D Reeves, H E Spence, C A Kletzing, J R Wygant
Two of the largest geomagnetic storms of the last decade were witnessed in 2015. On 17 March 2015, a coronal mass ejection-driven event occurred with a Dst (storm time ring current index) value reaching -223 nT. On 22 June 2015 another strong storm (Dst reaching -204 nT) was recorded. These two storms each produced almost total loss of radiation belt high-energy (E ≳ 1 MeV) electron fluxes. Following the dropouts of radiation belt fluxes there were complex and rather remarkable recoveries of the electrons extending up to nearly 10 MeV in kinetic energy...
July 2016: Journal of Geophysical Research. Space Physics
https://www.readbyqxmd.com/read/27867112/hydrogel-thickened-nanoemulsions-based-on-essential-oils-for-topical-delivery-of-psoralen-permeation-and-stability-studies
#7
Thaís Nogueira Barradas, Juliana Perdiz Senna, Stephani Araujo Cardoso, Sara Nicoli, Cristina Padula, Patrizia Santi, Francesca Rossi, K Gyselle de Holanda E Silva, Claudia R Elias Mansur
Nanoemulsions (NE) have attracted much attention due to their as dermal delivery systems for lipophilic drugs such as psoralens. However, NE feature low viscosity which might be unsuitable for topical application. In this work, we produced hydrogel-thickened nanoemulsions (HTN) using chitosan as thickening polymer to overcome the low viscosity attributed to NE. The aim of this study is to develop and characterize oil-in-water (o/w) HTN based on sweet fennel and clove essential oil to transdermal delivery of 8-methoxsalen (8-MOP)...
November 17, 2016: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/27853322/risk-factors-for-group-b-streptococcal-disease-in-neonates-of-mothers-with-negative-antenatal-testing
#8
V Parente, R H Clark, L Ku, C Fennell, M Johnson, E Morris, A Romaine, U Utin, D K Benjamin, J A Messina, P B Smith, R G Greenberg
OBJECTIVE: The aim of this study was to identify risk factors for early-onset group B Streptococcus (EOGBS) disease in neonates of mothers with negative antenatal screening. STUDY DESIGN: We performed a retrospective cohort study of neonates born to mothers with negative antenatal GBS screening between 2002 and 2012. Our primary outcome was EOGBS infection. We used multivariable logistic regression to assess factors associated with EOGBS. RESULTS: EOGBS was confirmed in 492 of the 179 818 neonates that met the study inclusion criteria...
November 17, 2016: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/27846345/systems-biology-for-organotypic-cell-cultures
#9
Sonia Grego, Edward R Dougherty, Francis J Alexander, Scott S Auerbach, Brian R Berridge, Michael L Bittner, Warren Casey, Philip C Cooley, Ajit Dash, Stephen S Ferguson, Timothy R Fennell, Brian T Hawkins, Anthony J Hickey, Andre Kleensang, Michael N J Liebman, Florian Martin, Elizabeth A Maull, Jason Paragas, Guilin Gary Qiao, Sreenivasa Ramaiahgari, Susan J Sumner, Miyoung Yoon
Translating in vitro biological data into actionable information related to human health holds the potential to improve disease treatment and risk assessment of chemical exposures. While genomics has identified regulatory pathways at the cellular level, translation to the organism level requires a multiscale approach accounting for intra-cellular regulation, inter-cellular interaction, and tissue/organ-level effects. Tissue-level effects can now be probed in vitro thanks to recently developed systems of three-dimensional (3D), multicellular, "organotypic" cell cultures, which mimic functional responses of living tissue...
November 14, 2016: ALTEX
https://www.readbyqxmd.com/read/27818855/energy-dependent-dynamics-of-kev-to-mev-electrons-in-the-inner-zone-outer-zone-and-slot-regions
#10
Geoffrey D Reeves, Reiner H W Friedel, Brian A Larsen, Ruth M Skoug, Herbert O Funsten, Seth G Claudepierre, Joseph F Fennell, Drew L Turner, Mick H Denton, Harlan E Spence, J Bernard Blake, Daniel N Baker
We present observations of the radiation belts from the Helium Oxygen Proton Electron and Magnetic Electron Ion Spectrometer particle detectors on the Van Allen Probes satellites that illustrate the energy dependence and L shell dependence of radiation belt enhancements and decays. We survey events in 2013 and analyze an event on 1 March in more detail. The observations show the following: (a) at all L shells, lower energy electrons are enhanced more often than higher energies; (b) events that fill the slot region are more common at lower energies; (c) enhancements of electrons in the inner zone are more common at lower energies; and (d) even when events do not fully fill the slot region, enhancements at lower energies tend to extend to lower L shells than higher energies...
January 2016: Journal of Geophysical Research. Space Physics
https://www.readbyqxmd.com/read/27806687/characteristics-of-gram-negative-urinary-tract-infections-caused-by-extended-spectrum-beta-lactamases-pivmecillinam-as-a-treatment-option-within-south-dublin-ireland
#11
Fardod O'Kelly, Siobhan Kavanagh, Rustom Manecksha, John Thornhill, Jérôme P Fennell
BACKGROUND: The prevalence of urinary tract infections (UTIs) caused by extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae is increasing and the therapeutic options are limited, especially in primary care. Recent indications have suggested pivmecillinam to be a suitable option. This pilot study aimed to assess the viability of pivmecillinam as a therapeutic option in a Dublin cohort of mixed community and healthcare origin. METHODS: A prospective measurement of mean and fractional inhibitory concentrations of antibiotic use in 95 patients diagnosed with UTI caused by ESBL-producing Enterobacteriaceae was carried out...
November 3, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27802973/qubic-a-bioconductor-package-for-qualitative-biclustering-analysis-of-gene-co-expression-data
#12
Yu Zhang, Juan Xie, Jinyu Yang, Anne Fennell, Chi Zhang, Qin Ma
MOTIVATION: Biclustering is widely used to identify co-expressed genes under subsets of all the conditions in a large-scale transcriptomic dataset. The program, QUBIC, is recognized as one of the most efficient and effective biclustering methods for biological data interpretation. However, its availability is limited to a C implementation and to a low-throughput web interface. RESULTS: An R implementation of QUBIC is presented here with two unique features: (i) a 82% average improved efficiency by refactoring and optimizing the source C code of QUBIC; and (ii) a set of comprehensive functions to facilitate biclustering-based biological studies, including the qualitative representation (discretization) of expression data, query-based biclustering, bicluster expanding, biclusters comparison, heatmap visualization of any identified biclusters and co-expression networks elucidation...
October 6, 2016: Bioinformatics
https://www.readbyqxmd.com/read/27802299/protective-effects-of-essential-oils-as-natural-antioxidants-against-hepatotoxicity-induced-by-cyclophosphamide-in-mice
#13
Salah A Sheweita, Lobna S El-Hosseiny, Munther A Nashashibi
Clinical application of cyclophosphamide (CP) as an anticancer drug is often limited due to its toxicity. CP is metabolized mainly in the liver by cytochrome P450 system into acrolein which is the proximate toxic metabolite. Many different natural antioxidants were found to alleviate the toxic effects of various toxic agents via different mechanisms. Therefore, the present study aimed at investigating the role of essential oils extracted from fennel, cumin and clove as natural antioxidants in the alleviation of hepatotoxicity induced by CP through assessment of hepatotoxicity biomarkers (AST, ALT, ALP), histopathology of liver tissues as well as other biochemical parameters involved in the metabolism of CP...
2016: PloS One
https://www.readbyqxmd.com/read/27789791/safety-and-outcomes-of-simultaneous-vasospasm-and-endovascular-aneurysm-treatment-svat-in-subarachnoid-hemorrhage
#14
REVIEW
Doniel Drazin, Vernard S Fennell, Edward Gifford, Carlito Lagman, Kunakorn Atchaneeyasakul, Randall C Edgell, Mahmoud Rayes, Andrew Xavier, Muhammad S Hussain, Rishi Gupta, Junaid S Kalia, Osama O Zaidat, Italo Linfante, Raul G Nogueira, Thanh Nguyen, Jamary Oliveira-Filho, Alexandre D M Barros, Alan Boulos, Michael J Alexander, Dileep R Yavagal
BACKGROUND: Simultaneous vasospasm and endovascular aneurysm treatment (SVAT) has been shown to be effective with good clinical outcomes in small series, but these studies have not examined predictive factors for clinical outcome after treatment. OBJECTIVE: To identify the safety and efficacy of SVAT in a large multicenter patient cohort and evaluate prognostic markers of clinical outcome following SVAT. METHODS: This study retrospectively enrolled 50 consecutive patients undergoing SVAT at 11 different centers...
October 27, 2016: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/27781067/quantitative-scrutinization-of-aflatoxins-in-different-spices-from-pakistan
#15
Narjis Naz, Aiza Kashif, Kinza Kanwal, Abdul Muqeet Khan, Mateen Abbas
The current research work aimed to access the contamination level of aflatoxins B1, B2, G1, and G2 in the household spices that are widely consumed in huge amounts. 200 different spice samples, 100 packed and 100 unpacked, were analyzed for the aflatoxins profile by HPLC with an incidence of 61.5% contamination out of which 53.66% samples exceed the EU limit. The results disclosed that the unpacked samples are more contaminated as compared to the packed samples except for white cumin seeds. Among packed and unpacked samples of spices, the maximum value of aflatoxins was detected in fennel, that is, 27...
2016: International Journal of Analytical Chemistry
https://www.readbyqxmd.com/read/27771928/anethole-and-its-role-in-chronic-diseases
#16
Ana Clara Aprotosoaie, Irina-Iuliana Costache, Anca Miron
Anethole is the main fragrance and bioactive compound of anise, fennel, and star anise spices and more than other 20 plant species. It is widely used as flavor agent in food industry and other industries, in cosmetics, perfumery, and pharmaceuticals. In the last few years, various studies have revealed multiple beneficial effects of anethole for human health, such as anti-inflammatory, anticarcinogenic and chemopreventive, antidiabetic, immunomodulatory, neuroprotective, or antithrombotic, that are mediated by the modulation of several cell signaling pathways, mainly NF-kB and TNF-α signaling, and various ion channels...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27768378/recombination-enhanced-surface-expansion-of-clusters-in-intense-soft-x-ray-laser-pulses
#17
Daniela Rupp, Leonie Flückiger, Marcus Adolph, Tais Gorkhover, Maria Krikunova, Jan Philippe Müller, Maria Müller, Tim Oelze, Yevheniy Ovcharenko, Benjamin Röben, Mario Sauppe, Sebastian Schorb, David Wolter, Rolf Mitzner, Michael Wöstmann, Sebastian Roling, Marion Harmand, Rolf Treusch, Mathias Arbeiter, Thomas Fennel, Christoph Bostedt, Thomas Möller
We studied the nanoplasma formation and explosion dynamics of single large xenon clusters in ultrashort, intense x-ray free-electron laser pulses via ion spectroscopy. The simultaneous measurement of single-shot diffraction images enabled a single-cluster analysis that is free from any averaging over the cluster size and laser intensity distributions. The measured charge state-resolved ion energy spectra show narrow distributions with peak positions that scale linearly with final ion charge state. These two distinct signatures are attributed to highly efficient recombination that eventually leads to the dominant formation of neutral atoms in the cluster...
October 7, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27765981/sea-fennel-crithmum-maritimum-l-phytochemical-profile-antioxidative-cholinesterase-inhibitory-and-vasodilatory-activity
#18
Ivana Generalić Mekinić, Ivica Blažević, Ivana Mudnić, Franko Burčul, Mia Grga, Danijela Skroza, Iva Jerčić, Ivica Ljubenkov, Mladen Boban, Mladen Miloš, Višnja Katalinić
Sea fennel, a rediscovered star of the coastal cuisine, has been investigated for its phytochemical profile and biological potential. Sea fennel flowers, stems and leaves were analyzed for essential oils (EOs) isolated by hydrodistillation, as well as non-volatiles obtained by ethanolic extraction. Limonene were found to be a dominant compound in EOs and ethanolic extracts; ranging from 57.5-74.2 % and 0.7-8.1 mg/g dry plant material, respectively. In addition total phenolic content was determined for ethanolic extracts...
July 2016: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/27765377/the-information-needs-of-adult-cancer-survivors-across-the-cancer-continuum-a-scoping-review
#19
Chloe Fletcher, Ingrid Flight, Janine Chapman, Kate Fennell, Carlene Wilson
OBJECTIVE: To provide an updated synthesis of the literature that investigates the self-reported information needs of people diagnosed with cancer across the cancer continuum. METHODS: We conducted a scoping review of the literature published from August 2003 to June 2015 and expanded an existing typology summarizing the information needs of people diagnosed with cancer. RESULTS: The majority of the included studies (n=104) focused on questions relevant to the diagnosis/active treatment phase of the cancer continuum (52...
October 12, 2016: Patient Education and Counseling
https://www.readbyqxmd.com/read/27756800/moving-toward-improved-teamwork-in-cancer-care-the-role-of-psychological-safety-in-team-communication
#20
Anshu K Jain, Mary L Fennell, Anees B Chagpar, Hannah K Connolly, Ingrid M Nembhard
Effective communication is a requirement in the teamwork necessary for improved coordination to deliver patient-centered, value-based cancer care. Communication is particularly important when care providers are geographically distributed or work across organizations. We review organizational and teams research on communication to highlight psychological safety as a key determinant of high-quality communication within teams. We first present the concept of psychological safety, findings about its communication effects for teamwork, and factors that affect it...
October 18, 2016: Journal of Oncology Practice
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