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https://www.readbyqxmd.com/read/28618088/a-comparison-of-barriers-to-mental-health-support-seeking-among-farming-and-non-farming-adults-in-rural-south-australia
#1
Melissa J Hull, Kate M Fennell, Kari Vallury, Martin Jones, James Dollman
OBJECTIVE: To assess the differences between farming and non-farming rural adults in perceived barriers to mental health service use. DESIGN: A cross-sectional survey, modified from the Barriers to Help-Seeking Scale (BHSS), was conducted using a computer-assisted telephone interview. SETTING: Respondents (age 52.6 ± 11.6 years) were recruited from three rural regions of South Australia. PARTICIPANTS: Approximately, 78 non-farmers and 45 farmers were included in analyses...
June 15, 2017: Australian Journal of Rural Health
https://www.readbyqxmd.com/read/28617136/essential-oil-extraction-chemical-analysis-and-anti-candida-activity-of-foeniculum-vulgare-miller-new-approaches
#2
Stefania Garzoli, Mijat Božović, Anna Baldisserotto, Manuela Sabatino, Stefania Cesa, Federico Pepi, Chiara Beatrice Vicentini, Stefano Manfredini, Rino Ragno
A comprehensive study on essential oil samples of Foeniculum vulgare Miller from Tarquinia (Italy) is reported. A 24-h systematic steam distillation was performed on different harvested samples applying different extraction times. The GC-MS analysis of the residue outcome showed o-cymene, α-phellandrene, α-pinene and estragole as the major constituents. The predominance and continued presence of o-cymene makes this fennel oil a rather unique chemotype. An evident correlation between the antifungal activity and phenological stage is demonstrated...
June 15, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28610933/herbal-laxatives-and-antiemetics-in-pregnancy
#3
Reza Samavati, Eszter Ducza, Judit Hajagos-Tóth, Robert Gaspar
Constipation appears in the 2nd and 3rd trimester of pregnancy, while nausea is the strongest in the 1st trimester. This review summarizes the applicability of herbal laxatives and antiemetics in pregnancy. A human study has shown that flax oil as laxative is safe from 2nd trimester. Human data is not available about the rhubarb, but animal studies reveal that its emodin content induces fetal abnormalities. Fenugreek induces teratogenic malformation both in human and animals. Senna seed is proved as a safe laxative in pregnancy...
June 10, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28600012/flow-diversion-after-aneurysmal-subarachnoid-hemorrhage
#4
REVIEW
Sabareesh K Natarajan, Hussain Shallwani, Vernard S Fennell, Jeffrey S Beecher, Hakeem J Shakir, Jason M Davies, Kenneth V Snyder, Adnan H Siddiqui, Elad I Levy
Flow diversion after aneurysmal subarachnoid hemorrhage (SAH) is the last treatment option for aneurysm occlusion when other methods of aneurysm treatment cannot be used because of the need for dual antiplatelet therapy. The authors' general protocol for treatment selection after aneurysmal SAH is provided to share with readers our approach to securing the aneurysm before embarking flow diversion for primary treatment or delayed adjunctive treatment to primary coiling. The authors' experience with flow diversion after aneurysmal SAH, review of pertinent literature, and the future of flow diversion after aneurysmal SAH are discussed...
July 2017: Neurosurgery Clinics of North America
https://www.readbyqxmd.com/read/28580933/coupled-multiferroic-domain-switching-in-the-canted-conical-spin-spiral-system-mn2geo4
#5
T Honda, J S White, A B Harris, L C Chapon, A Fennell, B Roessli, O Zaharko, Y Murakami, M Kenzelmann, T Kimura
Despite remarkable progress in developing multifunctional materials, spin-driven ferroelectrics featuring both spontaneous magnetization and electric polarization are still rare. Among such ferromagnetic ferroelectrics are conical spin spiral magnets with a simultaneous reversal of magnetization and electric polarization that is still little understood. Such materials can feature various multiferroic domains that complicates their study. Here we study the multiferroic domains in ferromagnetic ferroelectric Mn2GeO4 using neutron diffraction, and show that it features a double-Q conical magnetic structure that, apart from trivial 180(o) commensurate magnetic domains, can be described by ferromagnetic and ferroelectric domains only...
June 5, 2017: Nature Communications
https://www.readbyqxmd.com/read/28574706/application-of-structure-based-design-and-parallel-chemistry-to-identify-a-potent-selective-and-brain-penetrant-phosphodiesterase-2a-inhibitor
#6
Christopher J Helal, Eric P Arnold, Tracey L Boyden, Cheng Chang, Thomas A Chappie, Kimberly F Fennell, Michael D Forman, Mihaly Hajos, John F Harms, William E Hoffman, John M Humphrey, Zhijun Kang, Robin J Kleiman, Bethany L Kormos, Che-Wah Lee, Jiemin Lu, Noha Maklad, Laura McDowell, Scot Mente, Rebecca E O'Connor, Jayvardhan Pandit, Mary Piotrowski, Anne W Schmidt, Christopher J Schmidt, Hirokazu Ueno, Patrick R Verhoest, Edward X Yang
Phosphodiesterase 2A (PDE2A) inhibitors have been reported to demonstrate in vivo activity in preclinical models of cognition. To more fully explore the biology of PDE2A inhibition, we sought to identify potent PDE2A inhibitors with improved brain penetration as compared to current literature compounds. Applying estimated human dose calculations while simultaneously leveraging synthetically enabled chemistry and structure-based drug design has resulted in a highly potent, selective, brain penetrant compound 71 (PF-05085727) that effects in vivo biochemical changes commensurate with PDE2A inhibition along with behavioral and electrophysiological reversal of the effects of NMDA antagonists in rodents...
June 16, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28573495/rnf43-is-mutated-less-frequently-in-lynch-syndrome-compared-with-sporadic-microsatellite-unstable-colorectal-cancers
#7
Lochlan J Fennell, Mark Clendenning, Diane M McKeone, Saara H Jamieson, Samanthy Balachandran, Jennifer Borowsky, John Liu, Futoshi Kawamata, Catherine E Bond, Christophe Rosty, Matthew E Burge, Daniel D Buchanan, Barbara A Leggett, Vicki L J Whitehall
The WNT signaling pathway is commonly altered during colorectal cancer development. The E3 ubiquitin ligase, RNF43, negatively regulates the WNT signal through increased ubiquitination and subsequent degradation of the Frizzled receptor. RNF43 has recently been reported to harbor frequent truncating frameshift mutations in sporadic microsatellite unstable (MSI) colorectal cancers. This study assesses the relative frequency of RNF43 mutations in hereditary colorectal cancers arising in the setting of Lynch syndrome...
June 1, 2017: Familial Cancer
https://www.readbyqxmd.com/read/28562281/herbal-medicines-for-gastrointestinal-disorders-in-children-and-adolescents-a-systematic-review
#8
REVIEW
Dennis Anheyer, Jane Frawley, Anna Katharina Koch, Romy Lauche, Jost Langhorst, Gustav Dobos, Holger Cramer
CONTEXT: Gastrointestinal disorders are common childhood complaints. Particular types of complementary and alternative medicine, such as herbal medicine, are commonly used among children. Research information on efficacy, safety, or dosage forms is still lacking. OBJECTIVES: To systematically summarize effectiveness and safety of different herbal treatment options for gastrointestinal disorders in children. DATA SOURCES: Medline/PubMed, Scopus, and the Cochrane Library were searched through July 15, 2016...
May 4, 2017: Pediatrics
https://www.readbyqxmd.com/read/28557182/large-stokes-shift-ionic-liquid-dye
#9
Ralf Ludwig, Andranik Petrosyan, Franziska Fennel, Alexander Villinger, Stefan Lochbrunner, Stella Schmode
We have succeeded in incorporating the dye N-methyl-6-oxyquinolone [6MQz] in its protonated form as a cation into an ionic liquid (IL) and thus to synthesize an IL dye. The ionic liquid dye[6MQc][NTf2] was characterized by NMR, ATR IR and X-ray crystallography. The X-ray structure shows that a hydrogen bond between the hydroxyl group of the [6MQc]+ cation and one of the sulfonyl oxygen atoms of the [NTf2]¯ anion is formed and confirms ion-pairing. The fluorescence of the IL dye has a large Stokes shift of =116 nm and a quantum yield of F=0...
May 29, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28539938/effects-of-medicinal-plant-extracts-and-photosensitization-on-aflatoxin-producing-aspergillus-flavus-raper-and-fennell
#10
Loise M Njoki, Sheila A Okoth, Peter M Wachira
This study was undertaken with an aim of exploring the effectiveness of medicinal plant extracts in the control of aflatoxin production. Antifungal properties, photosensitization, and phytochemical composition of aqueous and organic extracts of fruits from Solanum aculeastrum, bark from Syzygium cordatum, and leaves from Prunus africana, Ocimum lamiifolium, Lippia kituiensis, and Spinacia oleracea were tested. Spores from four-day-old cultures of previously identified toxigenic fungi, UONV017 and UONV003, were used...
2017: International Journal of Microbiology
https://www.readbyqxmd.com/read/28509813/effect-of-foeniculum-vulgare-mill-fennel-on-menopausal-symptoms-in-postmenopausal-women-a-randomized-triple-blind-placebo-controlled-trial
#11
Fatemeh Rahimikian, Roja Rahimi, Parvin Golzareh, Reza Bekhradi, Abbas Mehran
OBJECTIVE: Preliminary data suggest that Foeniculum vulgare (fennel) can be an effective treatment for menopausal symptoms. This trial was designed to assess the efficacy of fennel in the management of menopausal symptoms in postmenopausal women. METHODS: In this triple-blind, placebo-controlled trial, 90 postmenopausal women aged 45 to 60 years in Tehran were randomly assigned to treatment (n = 45) or placebo (n = 45) groups. The participants received 8 weeks of treatment with soft capsules containing 100 mg fennel or a placebo (2 per day for each group)...
May 15, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28500688/fennel-foeniculum-vulgare-mill-subsp-piperitum-florets-a-traditional-culinary-spice-in-italy-evaluation-of-phenolics-and-volatiles-in-local-populations-and-comparison-with-the-composition-of-other-plant-parts
#12
Federico Ferioli, Elisa Giambanelli, L Filippo D'Antuono
BACKGROUND: Wild fennel (Foeniculum vulgare Mill. subsp. piperitum) florets are used as a typical spice in central and southern Italy. Although fennel (Foeniculum vulgare Mill.), belonging to Apiaceae (syn. Umbelliferae) family, is a well-known vegetable and aromatic plant, whose main phytochemical compounds have been extensively analysed and investigated as flavouring agents and for their putative health promoting functions, its florets have not been specifically considered up to now...
May 13, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28490965/protective-effects-of-fennel-oil-extract-against-sodium-valproate-induced-hepatorenal-damage-in-albino-rats
#13
Wael M Al-Amoudi
Foeniculum vulgare (Apiaceae) is commonly known as fennel. This herb is well-known worldwide and traditionally used as curative herbal therapy for the treatment of epileptic disease, seizurescarminative, digestive, lactogogue, diuretic, treating respiratory and gastrointestinal disorders. The aim of present study is to investigate the possible effect of fennel oil against the toxicity of Sodium-Valproic (SVP) in albino rats. In order to assess the protection of fennel oil on SVP induced hepato- and nephro-toxicity, male albino rats were treated with 1 ml/kg b...
May 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/28478861/demographic-characteristics-call-details-and-psychosocial-support-needs-of-the-family-friends-of-someone-diagnosed-with-cancer-who-access-australian-cancer-council-telephone-information-and-support-services
#14
Leila Heckel, Kate M Fennell, Mohammadreza Mohebbi, Monica Byrnes, Patricia M Livingston
PURPOSE: Community-based cancer organizations provide telephone-based information and support services to assist people diagnosed with cancer and their family/friends. We investigated the demographic characteristics and psychosocial support needs of family/friends who contacted Australian Cancer Council 13 11 20 information and support helplines. METHODS: Data collected on 42,892 family/friends who contacted a 13 11 20 service across Australia from January 2010 to December 2012 were analyzed...
June 2017: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
https://www.readbyqxmd.com/read/28452929/chemiresistor-devices-for-chemical-warfare-agent-detection-based-on-polymer-wrapped-single-walled-carbon-nanotubes
#15
John F Fennell, Hitoshi Hamaguchi, Bora Yoon, Timothy M Swager
Chemical warfare agents (CWA) continue to present a threat to civilian populations and military personnel in operational areas all over the world. Reliable measurements of CWAs are critical to contamination detection, avoidance, and remediation. The current deployed systems in United States and foreign militaries, as well as those in the private sector offer accurate detection of CWAs, but are still limited by size, portability and fabrication cost. Herein, we report a chemiresistive CWA sensor using single-walled carbon nanotubes (SWCNTs) wrapped with poly(3,4-ethylenedioxythiophene) (PEDOT) derivatives...
April 28, 2017: Sensors
https://www.readbyqxmd.com/read/28445469/phylogenetic-ctdna-analysis-depicts-early-stage-lung-cancer-evolution
#16
Christopher Abbosh, Nicolai J Birkbak, Gareth A Wilson, Mariam Jamal-Hanjani, Tudor Constantin, Raheleh Salari, John Le Quesne, David A Moore, Selvaraju Veeriah, Rachel Rosenthal, Teresa Marafioti, Eser Kirkizlar, Thomas B K Watkins, Nicholas McGranahan, Sophia Ward, Luke Martinson, Joan Riley, Francesco Fraioli, Maise Al Bakir, Eva Grönroos, Francisco Zambrana, Raymondo Endozo, Wenya Linda Bi, Fiona M Fennessy, Nicole Sponer, Diana Johnson, Joanne Laycock, Seema Shafi, Justyna Czyzewska-Khan, Andrew Rowan, Tim Chambers, Nik Matthews, Samra Turajlic, Crispin Hiley, Siow Ming Lee, Martin D Forster, Tanya Ahmad, Mary Falzon, Elaine Borg, David Lawrence, Martin Hayward, Shyam Kolvekar, Nikolaos Panagiotopoulos, Sam M Janes, Ricky Thakrar, Asia Ahmed, Fiona Blackhall, Yvonne Summers, Dina Hafez, Ashwini Naik, Apratim Ganguly, Stephanie Kareht, Rajesh Shah, Leena Joseph, Anne Marie Quinn, Phil A Crosbie, Babu Naidu, Gary Middleton, Gerald Langman, Simon Trotter, Marianne Nicolson, Hardy Remmen, Keith Kerr, Mahendran Chetty, Lesley Gomersall, Dean A Fennell, Apostolos Nakas, Sridhar Rathinam, Girija Anand, Sajid Khan, Peter Russell, Veni Ezhil, Babikir Ismail, Melanie Irvin-Sellers, Vineet Prakash, Jason F Lester, Malgorzata Kornaszewska, Richard Attanoos, Haydn Adams, Helen Davies, Dahmane Oukrif, Ayse U Akarca, John A Hartley, Helen L Lowe, Sara Lock, Natasha Iles, Harriet Bell, Yenting Ngai, Greg Elgar, Zoltan Szallasi, Roland F Schwarz, Javier Herrero, Aengus Stewart, Sergio A Quezada, Karl S Peggs, Peter Van Loo, Caroline Dive, C Jimmy Lin, Matthew Rabinowitz, Hugo J W L Aerts, Allan Hackshaw, Jacqui A Shaw, Bernhard G Zimmermann, Charles Swanton
The early detection of relapse following primary surgery for non-small-cell lung cancer and the characterization of emerging subclones, which seed metastatic sites, might offer new therapeutic approaches for limiting tumour recurrence. The ability to track the evolutionary dynamics of early-stage lung cancer non-invasively in circulating tumour DNA (ctDNA) has not yet been demonstrated. Here we use a tumour-specific phylogenetic approach to profile the ctDNA of the first 100 TRACERx (Tracking Non-Small-Cell Lung Cancer Evolution Through Therapy (Rx)) study participants, including one patient who was also recruited to the PEACE (Posthumous Evaluation of Advanced Cancer Environment) post-mortem study...
April 26, 2017: Nature
https://www.readbyqxmd.com/read/28445112/tracking-the-evolution-of-non-small-cell-lung-cancer
#17
Mariam Jamal-Hanjani, Gareth A Wilson, Nicholas McGranahan, Nicolai J Birkbak, Thomas B K Watkins, Selvaraju Veeriah, Seema Shafi, Diana H Johnson, Richard Mitter, Rachel Rosenthal, Max Salm, Stuart Horswell, Mickael Escudero, Nik Matthews, Andrew Rowan, Tim Chambers, David A Moore, Samra Turajlic, Hang Xu, Siow-Ming Lee, Martin D Forster, Tanya Ahmad, Crispin T Hiley, Christopher Abbosh, Mary Falzon, Elaine Borg, Teresa Marafioti, David Lawrence, Martin Hayward, Shyam Kolvekar, Nikolaos Panagiotopoulos, Sam M Janes, Ricky Thakrar, Asia Ahmed, Fiona Blackhall, Yvonne Summers, Rajesh Shah, Leena Joseph, Anne M Quinn, Phil A Crosbie, Babu Naidu, Gary Middleton, Gerald Langman, Simon Trotter, Marianne Nicolson, Hardy Remmen, Keith Kerr, Mahendran Chetty, Lesley Gomersall, Dean A Fennell, Apostolos Nakas, Sridhar Rathinam, Girija Anand, Sajid Khan, Peter Russell, Veni Ezhil, Babikir Ismail, Melanie Irvin-Sellers, Vineet Prakash, Jason F Lester, Malgorzata Kornaszewska, Richard Attanoos, Haydn Adams, Helen Davies, Stefan Dentro, Philippe Taniere, Brendan O'Sullivan, Helen L Lowe, John A Hartley, Natasha Iles, Harriet Bell, Yenting Ngai, Jacqui A Shaw, Javier Herrero, Zoltan Szallasi, Roland F Schwarz, Aengus Stewart, Sergio A Quezada, John Le Quesne, Peter Van Loo, Caroline Dive, Allan Hackshaw, Charles Swanton
BACKGROUND: Among patients with non-small-cell lung cancer (NSCLC), data on intratumor heterogeneity and cancer genome evolution have been limited to small retrospective cohorts. We wanted to prospectively investigate intratumor heterogeneity in relation to clinical outcome and to determine the clonal nature of driver events and evolutionary processes in early-stage NSCLC. METHODS: In this prospective cohort study, we performed multiregion whole-exome sequencing on 100 early-stage NSCLC tumors that had been resected before systemic therapy...
June 1, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28428087/searching-for-new-sources-of-innovative-products-for-the-food-industry-within-halophyte-aromatic-plants-in-vitro-antioxidant-activity-and-phenolic-and-mineral-contents-of-infusions-and-decoctions-of-crithmum-maritimum-l
#18
Catarina Guerreiro Pereira, Luísa Barreira, Nuno da Rosa Neng, José Manuel Florêncio Nogueira, Cátia Marques, Tamára F Santos, João Varela, Luísa Custódio
Aromatic halophyte plants are an outstanding source of bioactive compounds and natural products with potential use in the food industry. This work reports the in vitro antioxidant activity, toxicity, polyphenolic profile and mineral contents of infusions and decoctions from stems, leaves and flowers of Crithmum maritimum L., an aromatic and edible maritime halophyte (sea fennel). Aspalathus linearis (Burm.f.) Dahlg. (rooibos) herbal tea was used as a reference. Sea fennel's tisanes, particularly from leaves, were rich in phenolic compounds and five of them (p-hydroxybenzoic and ferulic acids, epicatechin, pyrocatechol and 4-hydroxybenzaldehyde) were here described in C...
April 17, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28397764/screening-purification-and-characterization-of-anionic-antimicrobial-proteins-from-foeniculum-vulgare
#19
Raid Al Akeel, Ayesha Mateen, Rabbani Syed, Abdullah A Alyousef, Mohammed Rafi Shaik
Foeniculum vulgare Mill., commonly called fennel, is a medicinal plant belonging to the Umbelliferae (Apiaceae) family, and is used in traditional medicine. Antibacterial peptides were isolated using sodium phosphate citrate buffer and, for extraction, cetyltrimethyl ammonium bromide (CTAB) buffer with pH 6, have been employed and antimicrobial activity tested against four reference strains. The extracted protein was subjected to 3 kDa dialysis and separation was carried out by DEAE-ion exchange chromatography and further proteins were identified by 2D gel electrophoresis...
April 8, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28373066/role-of-d-amphetamine-and-d-methamphetamine-as-active-metabolites-of-benzphetamine-evidence-from-drug-discrimination-and-pharmacokinetic-studies-in-male-rhesus-monkeys
#20
Matthew L Banks, Rodney W Snyder, Timothy R Fennell, S Stevens Negus
Benzphetamine is a Schedule III anorectic agent that is a prodrug for d-amphetamine and d-methamphetamine and may have utility as an "agonist" medication for cocaine use disorder treatment. This study evaluated the pharmacokinetic-pharmacodynamic profile of benzphetamine using a drug discrimination procedure in rhesus monkeys. The potency and time course of cocaine-like discriminative stimulus effects were compared for benzphetamine (10-18mg/kg, intramuscular (IM)) and d-amphetamine (0.032-0.32mg/kg, IM) in monkeys (n=3-4) trained to discriminate IM cocaine (0...
March 31, 2017: Pharmacology, Biochemistry, and Behavior
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