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https://www.readbyqxmd.com/read/29238281/differential-inhibitory-activities-of-four-plant-essential-oils-on-in-vitro-growth-of-fusarium-oxysporum-f-sp-fragariae-causing-fusarium-wilt-in-strawberry-plants
#1
Jin Young Park, Su Hyeon Kim, Na Hee Kim, Sang Woo Lee, Yong-Chull Jeun, Jeum Kyu Hong
The objective of this study was to determine inhibitory activities of four volatile plant essential oils (cinnamon oil, fennel oil, origanum oil and thyme oil) on in vitro growth of Fusarium oxysporum f. sp. fragariae causing Fusarium wilt of strawberry plants. Results showed that these essential oils inhibited in vitro conidial germination and mycelial growth of F. oxysporum f. sp. fragariae in a dose-dependent manner. Cinnamon oil was found to be most effective one in suppressing conidial germination while fennel oil, origanum oil and thyme oil showed moderate inhibition of conidial germination at similar levels...
December 2017: Plant Pathology Journal
https://www.readbyqxmd.com/read/29235923/oncogenic-braf-mutation-induces-dna-methylation-changes-in-a-murine-model-for-human-serrated-colorectal-neoplasia
#2
Catherine E Bond, Cheng Liu, Futoshi Kawamata, Diane M McKeone, Winnie Fernando, Saara Jamieson, Sally-Ann Pearson, Alexandra Kane, Susan L Woods, Tamsin R M Lannagan, Roshini Somashekar, Young Lee, Troy Dumenil, Gunter Hartel, Kevin J Spring, Jennifer Borowsky, Lochlan Fennell, Mark Bettington, Jason Lee, Daniel L Worthley, Barbara A Leggett, Vicki L J Whitehall
Colorectal cancer is a major cause of cancer death and approximately 20% arises within serrated polyps, which are under-recognized and poorly understood. Human serrated colorectal polyps frequently exhibit both oncogenic BRAF mutation and widespread DNA methylation changes, which are important in silencing genes restraining neoplastic progression. Here, we investigated whether in vivo induction of mutant Braf is sufficient to result in coordinated promoter methylation changes for multiple cancer-related genes...
December 13, 2017: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/29233689/in-vitro-toxicity-evaluation-of-estragole-containing-preparations-derived-from-foeniculum-vulgare-mill-fennel-on-hepg2-cells
#3
Sara Levorato, Luca Dominici, Cristina Fatigoni, Claudia Zadra, Rita Pagiotti, Massimo Moretti, Milena Villarini
Estragole, a common component of herbs and spices, is a wellknown genotoxic hepatocarcinogen in rodents, whereas its potential toxic effect in humans is still debated. In the European contest, one of the major sources of human exposure to this phytochemical is Foeniculum vulgare Mill. (fennel). Therefore, the aim of this study was to evaluate the in vitro toxicity of estragole in the context of two complex phytochemical mixtures derived from fennel: fennel seed powder (FSPw) and fennel seed essential oil (FSEO)...
December 9, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29207708/in-vitro-anti-cariogenic-plaque-effects-of-essential-oils-extracted-from-culinary-herbs
#4
Kornsit Wiwattanarattanabut, Suwan Choonharuangdej, Theerathavaj Srithavaj
Introduction: Cariogenic bacteria including mutans streptococci and lactobacilli are partly but significantly involved in dental caries development. An effective prevention strategy against dental caries is to decrease the accumulation of this microbiota either in planktonic or in biofilm form. Aim: To examine the antimicrobial and anti-plaque effects of some culinary herbs (spices), so the herbs are plausibly used as alternative and effective herbal plaque control supplements to promote good oral health...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29191726/essential-oils-of-culinary-herbs-and-spices-display-agonist-and-antagonist-activities-at-human-aryl-hydrocarbon-receptor-ahr
#5
Iveta Bartoňková, Zdeněk Dvořák
Essential oils (EOs) of culinary herbs and spices are used to flavor, color and preserve foods and drinks. Dietary intake of EOs is significant, deserving an attention of toxicologists. We examined the effects of 31 EOs of culinary herbs and spices on the transcriptional activity of human aryl hydrocarbon receptor (AhR), which is a pivotal xenobiotic sensor, having also multiple roles in human physiology. Tested EOs were sorted out into AhR-inactive ones (14 EOs) and AhR-active ones, including full agonists (cumin, jasmine, vanilla, bay leaf), partial agonists (cloves, dill, thyme, nutmeg, oregano) and antagonists (tarragon, caraway, turmeric, lovage, fennel, spearmint, star anise, anise)...
November 27, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29178169/authentication-of-commercial-spices-based-on-the-similarities-between-gas-chromatographic-fingerprints
#6
Takaya Matsushita, JingJing Zhao, Noriyuki Igura, Mitsuya Shimoda
BACKGROUND: A simple and solvent-free method was developed for the authentication of commercial spices. The similarities between gas chromatographic fingerprints were measured using similarity indices and multivariate data analyses, as morphological differentiation between dried powders and small spice particles was challenging. The volatile compounds present in 11 spices (i.e., allspice, anise, black pepper, caraway, clove, coriander, cumin, dill, fennel, star anise, and white pepper) were extracted by headspace solid-phase microextraction, and analyzed by gas chromatography-mass spectrometry...
November 27, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29175783/total-antioxidant-capacity-of-commonly-used-fruits-vegetables-herbs-and-spices-of-pakistan
#7
Mobasher Ali Abid, Muhammad Ashfaq, Muhammad Junaid Hassan Sharif, Khalid Rauf, Wajahat Mahmood, Ikarmullah Khan, Ghulam Abbas
The current study was aimed at investigating the total antioxidant activity (TAC) of various fruits, vegetables, herbs and spices habitat in Pakistan. The ferric reducing ability of plasma (FRAP) assay was used to measure the TAC of various extracts (aqueous, ethanolic and aqueous-ethanolic). Following is the potency order for fruits (guava >strawberry >Pomegranate >apple >kinnow >melon >lemon >banana), vegetables (spinach >Cabbage (Purple) >Jalapeno >Radish >Brinjal >Bell Pepper >Lettuce >Carrot >Cabbage (White) >Onion >Potato >Tomato >Cucumber) and herbs/spices (clove >Rosemary >Thyme >Oregano >Cinnamon >Cumin >Kalonji >Paprika >Neem (Flower) >Fennel >Black Cardamom >Turmeric >Coriander >Ginger >Garlic)...
November 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29166815/disposition-of-14-c-hydroquinone-in-harlan-sprague-dawley-rats-and-b6c3f1-n-mice-species-and-route-comparison
#8
Sherry R Black, Timothy R Fennell, James M Mathews, Rodney W Snyder, Purvi R Patel, Scott L Watson, Vicki Sutherland, Suramya Waidyanatha
1. Hydroquinone (HQ) is present in some foods and has varied industrial, medical and consumer uses. These studies were undertaken to investigate the disposition of HQ in rats and mice following gavage, intravenous (IV) and dermal exposure. 2. [(14 )C]HQ administered (0.5, 5 or 50 mg/kg) by gavage or IV routes to male and female Harlan Sprague-Dawley (HSD) rats and B6C3F1/N mice was well absorbed and rapidly excreted primarily in urine. Radioactivity remaining in tissues at 72 h was <1% for both species at all dose levels and routes...
November 22, 2017: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/29165921/impact-of-flue-gas-compounds-on-microalgae-and-mechanisms-for-carbon-assimilation-and-utilization-a-review
#9
Arun Krishna Vuppaladadiyam, Joseph G Yao, Nicholas Florin, Anthe George, Xiaoxiong Wang, Leen Labeeuw, Yuelu Jiang, Ryan W Davis, Ali Abbas, Peter Ralph, Paul S Fennell, Ming Zhao
In order to shift the world to a more sustainable future, it is necessary to phase out the use of fossil fuels and focus on the development of low-carbon alternatives. However, this transition is slow so there still exists a large dependence on fossil-derived power and therefore CO2 release. Owing to the potential for assimilating and utilizing CO2 to generate carbon neutral products such as biodiesel, the application of microalgae technology to capture CO2 from flue gases has gained significant attention over the past decade...
November 22, 2017: ChemSusChem
https://www.readbyqxmd.com/read/29154916/acute-intravenous-exposure-to-silver-nanoparticles-during-pregnancy-induces-particle-size-and-vehicle-dependent-changes-in-vascular-tissue-contractility-in-sprague-dawley-rats
#10
A K Vidanapathirana, L C Thompson, M Herco, J Odom, S J Sumner, T R Fennell, J M Brown, C J Wingard
The use of silver nanoparticles (AgNP) raises safety concerns during susceptible life stages such as pregnancy. We hypothesized that acute intravenous exposure to AgNP during late stages of pregnancy will increase vascular tissue contractility, potentially contributing to alterations in fetal growth. Sprague Dawley rats were exposed to a single dose of PVP or Citrate stabilized 20 or 110nm AgNP (700μg/kg). Differential vascular responses and EC50 values were observed in myographic studies in uterine, mesenteric arteries and thoracic aortic segments, 24h post-exposure...
November 20, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/29148769/azetidine-and-piperidine-carbamates-as-efficient-covalent-inhibitors-of-monoacylglycerol-lipase
#11
Christopher R Butler, Elizabeth M Beck, Anthony R Harris, Zhen Huang, Laura A McAllister, Christopher W Am Ende, Kimberly F Fennell, Timothy L Foley, Kari R Fonseca, Steven J Hawrylik, Douglas S Johnson, John D Knafels, Scot Mente, Stephen Noell, Jayvardhan Pandit, Tracy B Phillips, Justin R Piro, Bruce N Rogers, Tarek A Samad, Jane Wang, Shuangyi Wan, Michael A Brodney
Monoacylglycerol lipase (MAGL) is the main enzyme responsible for degradation of the endocannabinoid 2-arachidonoylglycerol (2-AG) in the CNS. MAGL catalyzes the conversion of 2-AG to arachidonic acid (AA), a precursor to the pro-inflammatory eicosannoids such as prostaglandins. Herein we describe highly efficient MAGL inhibitors, identified through a parallel medicinal chemistry approach that highlighted the improved efficiency of azetidine and piperidine-derived carbamates. The discovery and optimization of 3-substituted azetidine carbamate irreversible inhibitors of MAGL was aided by the generation of inhibitor-bound MAGL crystal structures...
November 17, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29148535/the-role-of-apc-in-wnt-pathway-activation-in-serrated-neoplasia
#12
Jennifer Borowsky, Troy Dumenil, Mark Bettington, Sally-Ann Pearson, Catherine Bond, Lochlan Fennell, Cheng Liu, Diane McKeone, Christophe Rosty, Ian Brown, Neal Walker, Barbara Leggett, Vicki Whitehall
Conventional adenomas are initiated by APC gene mutation that activates the WNT signal. Serrated neoplasia is commonly initiated by BRAF or KRAS mutation. WNT pathway activation may also occur, however, to what extent this is owing to APC mutation is unknown. We examined aberrant nuclear β-catenin immunolocalization as a surrogate for WNT pathway activation and analyzed the entire APC gene coding sequence in serrated and conventional pathway polyps and cancers. WNT pathway activation was a common event in conventional pathway lesions with aberrant nuclear immunolocalization of β-catenin and truncating APC mutations in 90% and 89% of conventional adenomas and 82% and 70% of BRAF wild-type cancers, respectively...
November 17, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29144458/biogeochemistry-ocean-hotspots-of-nitrogen-loss
#13
Katja Fennel
No abstract text is available yet for this article.
November 15, 2017: Nature
https://www.readbyqxmd.com/read/29127437/-morbidity-and-mortality-due-to-meningioma-after-cranial-radiotherapy
#14
Anca-Ligia Grosu, Jamina Tara Fennell
No abstract text is available yet for this article.
November 10, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29111853/metabolism-and-disposition-of-2-ethylhexyl-p-methoxycinnamate-following-oral-gavage-and-dermal-exposure-in-harlan-sprague-dawley-rats-and-b6c3f1-n-mice-and-in-hepatocytes-in-vitro
#15
Timothy R Fennell, James M Mathews, Rodney W Snyder, Yang Hong, Scott L Watson, Sherry R Black, Barry S McIntyre, Suramya Waidyanatha
1. 2-Ethylhexyl-p-methoxycinnamate (EHMC) is commonly used as an ingredient in sunscreens, resulting in potential oral and dermal exposure in humans. 2. Clearance and metabolism of EHMC in hepatocytes and disposition and metabolism of EHMC in rodents following oral (8 to 800 mg/kg) intravenous (IV) (8 mg/kg), or dermal (0.8 to 80 mg/kg representing 0.1 to 10% formulation concentration) exposure to [(14)C]EHMC were investigated in rats and mice. 3. EHMC was rapidly cleared from rat and mouse hepatocytes (half-life ≤ 3...
November 7, 2017: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/29104327/dayside-response-of-the-magnetosphere-to-a-small-shock-compression-van-allen-probes-magnetospheric-multiscale-and-goes-13
#16
C Cattell, A Breneman, C Colpitts, J Dombeck, S Thaller, S Tian, J Wygant, J Fennell, M K Hudson, Robert Ergun, C T Russell, Roy Torbert, Per-Arne Lindqvist, J Burch
Observations from Magnetospheric MultiScale (~8 Re) and Van Allen Probes (~5 and 4 Re) show that the initial dayside response to a small interplanetary shock is a double-peaked dawnward electric field, which is distinctly different from the usual bipolar (dawnward and then duskward) signature reported for large shocks. The associated E × B flow is radially inward. The shock compressed the magnetopause to inside 8 Re, as observed by Magnetospheric MultiScale (MMS), with a speed that is comparable to the E × B flow...
September 16, 2017: Geophysical Research Letters
https://www.readbyqxmd.com/read/29084156/the-dietary-furocoumarin-imperatorin-increases-plasma-glp-1-levels-in-type-1-like-diabetic-rats
#17
Lin-Yu Wang, Kai-Chun Cheng, Yingxiao Li, Chiang-Shan Niu, Juei-Tang Cheng, Ho-Shan Niu
Imperatorin, a dietary furocoumarin, is found not only in medicinal plants, but also in popular culinary herbs, such as parsley and fennel. Recently, imperatorin has been shown to activate GPR119 in cells. Another GPR, GPR131, also called TGR5 or G-protein-coupled bile acid receptor 1 (GPBAR1), is known to regulate glucose metabolism. Additionally, TGR5 activation increases glucagon-like peptide (GLP-1) secretion to lower blood sugar levels in animals. Therefore, the present study aims to determine whether the effects of imperatorin on GLP-1 secretion are mediated by TGR5...
October 30, 2017: Nutrients
https://www.readbyqxmd.com/read/29081493/nanoplasmonic-electron-acceleration-by-attosecond-controlled-forward-rescattering-in-silver-clusters
#18
Johannes Passig, Sergey Zherebtsov, Robert Irsig, Mathias Arbeiter, Christian Peltz, Sebastian Göde, Slawomir Skruszewicz, Karl-Heinz Meiwes-Broer, Josef Tiggesbäumker, Matthias F Kling, Thomas Fennel
In the strong-field photoemission from atoms, molecules, and surfaces, the fastest electrons emerge from tunneling and subsequent field-driven recollision, followed by elastic backscattering. This rescattering picture is central to attosecond science and enables control of the electron's trajectory via the sub-cycle evolution of the laser electric field. Here we reveal a so far unexplored route for waveform-controlled electron acceleration emerging from forward rescattering in resonant plasmonic systems. We studied plasmon-enhanced photoemission from silver clusters and found that the directional acceleration can be controlled up to high kinetic energy with the relative phase of a two-color laser field...
October 30, 2017: Nature Communications
https://www.readbyqxmd.com/read/29079080/analysis-of-airborne-microbial-communities-using-16s-ribosomal-rna-potential-bias-due-to-air-sampling-stress
#19
Huajun Zhen, Valdis Krumins, Donna E Fennell, Gediminas Mainelis
A limited number of studies have been conducted to analyze ribosomal RNA (rRNA, present in the ribosome) in bioaerosol samples to identify currently or potentially active airborne microbes, although its genomic counterpart, the rRNA gene (on the chromosome) has been frequently targeted for airborne microbial community analysis. A knowledge gap still exists regarding whether the bioaerosol rRNA abundances are affected by the bioaerosol collection process. We investigated the effect of air sampling stress on the measurement and characterization of 16S rRNA for bioaerosols in the laboratory and field experiments using quantitative polymerase chain reaction (qPCR) and high-throughput sequencing techniques...
October 24, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29034684/ynol-ethers-as-ketene-equivalents-in-rhodium-catalyzed-intermolecular-5-2-cycloaddition-reactions
#20
Paul A Wender, Christian Ebner, Brandon D Fennell, Fuyuhiko Inagaki, Birte Schröder
The previously unexplored metal-catalyzed [5 + 2] cycloadditions of vinylcyclopropanes (VCPs) and electron-rich alkynes (ynol ethers) have been found to provide a highly efficient, direct route to dioxygenated seven-membered rings, a common feature of numerous natural and non-natural targets and building blocks for synthesis. The reactions proceed in high yield at room temperature and tolerate a broad range of functionalities. Substituted VCPs were found to react with high regioselectivity.
October 16, 2017: Organic Letters
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