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Paul A Wender, Christian Ebner, Brandon D Fennell, Fuyuhiko Inagaki, Birte Schröder
The previously unexplored metal-catalyzed [5 + 2] cycloadditions of vinylcyclopropanes (VCPs) and electron-rich alkynes (ynol ethers) have been found to provide a highly efficient, direct route to dioxygenated seven-membered rings, a common feature of numerous natural and non-natural targets and building blocks for synthesis. The reactions proceed in high yield at room temperature and tolerate a broad range of functionalities. Substituted VCPs were found to react with high regioselectivity.
October 16, 2017: Organic Letters
Yoonjee Chang, Soo-Hyun Lee, Ja Hyun Na, Pahn-Shick Chang, Jaejoon Han
The purpose of this study was to develop an anti-insect pest repellent sachet to prevent Sitophilus oryzae (L.) (Coleoptera: Curculionidae) contamination in grain packaging. The anti-insect pest activities of essential oils (EOs) from garlic (Allium Sativum), ginger (Zingiber Officinalis), black pepper (Piper nigrum), onion (Allium cepa), and fennel (Foeniculum vulgare) as well as major compounds (allyl disulfide, AD; allyl mercaptan, AM) isolated from of garlic and onion (AD and AM) were measured against S...
October 14, 2017: Journal of Food Science
Romain Sibille, Elsa Lhotel, Monica Ciomaga Hatnean, Gøran J Nilsen, Georg Ehlers, Antonio Cervellino, Eric Ressouche, Matthias Frontzek, Oksana Zaharko, Vladimir Pomjakushin, Uwe Stuhr, Helen C Walker, Devashibhai T Adroja, Hubertus Luetkens, Chris Baines, Alex Amato, Geetha Balakrishnan, Tom Fennell, Michel Kenzelmann
The charge ordered structure of ions and vacancies characterizing rare-earth pyrochlore oxides serves as a model for the study of geometrically frustrated magnetism. The organization of magnetic ions into networks of corner-sharing tetrahedra gives rise to highly correlated magnetic phases with strong fluctuations, including spin liquids and spin ices. It is an open question how these ground states governed by local rules are affected by disorder. Here we demonstrate in the pyrochlore Tb2Hf2O7, that the vicinity of the disordering transition towards a defective fluorite structure translates into a tunable density of anion Frenkel disorder while cations remain ordered...
October 12, 2017: Nature Communications
Masumeh Ghazanfarpour, Paymaneh Shokrollahi, Talat Khadivzadeh, Nosrat Baharian Sharghi, Khadijeh Mirzaii Najmabadi, Masoudeh Babakhanian, Amir Hossine Jafarian
Objectives This study was conducted to evaluate the effects of orally administered fennel on vaginal atrophy. Materials and methods In this double-blind, randomized, placebo-controlled trial, 60 postmenopausal women living in Mashhad, Iran, were randomly divided into an oral fennel group (n = 30) and a placebo group (n = 30). The Maturation Vaginal Index and maturation values were measured once at baseline and again upon a three-month follow-up. Results The paired t-test showed statistically significant changes in the Maturation Vaginal Index (i...
January 1, 2017: Post Reproductive Health
Macarena Egea, Mª Belén Linares, Marta Gil, Mª Belén López, Mª Dolores Garrido
BACKGROUND: Consumers highly sensitive to androstenone will probably reject meat from entire male pigs, which tends to have high levels of this hormone. To avoid this, the effect of different masking strategies (sprinkling with mixed spices or fennel, marinating and breading with garlic-parsley or curry) on the sensory parameters of pork loin chops obtained from entire animals with high levels of androstenone (AND) (1.0-2.9 mg kg (-1) AND in fat) and castrated animals (<0.4 mg kg (-1) AND in fat), both with low levels of skatole (SKA) (<0...
October 5, 2017: Journal of the Science of Food and Agriculture
Tim Martindale, Phillip McGlone, Robert Chambers, Jon Fennell
The effects of a high carbon dioxide on cerebral perfusion and intracranial pressure are well known. We report the case of a man who presented after with a severe traumatic brain injury including intracranial and extradural haemorrhage. Neuroprotective ventilation was impossible without supramaximal tidal volumes due to a combination of chest trauma and severe bronchospasm. A pump driven Novalung iLA active® system was inserted to achieve both ARDSnet ventilation and a lowering of intracranial pressure. To our knowledge, this is the first time this system has been used to this effect...
February 2017: J Intensive Care Soc
Mathias Meyer, Rozemarijn Vliegenthart, Thomas Henzler, Daniel Buergy, Frank A Giordano, Michael Kostrzewa, Nils Rathmann, Odd Terje Brustugun, Lucio Crino, Anne-Marie C Dingemans, Michael Dusmet, Dean Fennell, Dominique Grunenwald, Rudolf Maria Huber, Marcin Moniuszko, Francoise Mornex, Mauro Papotti, Lothar Pilz, Suresh Senan, Kostas Syrigos, Maurice Pérol, Jhanelle E Gray, Christoph Schabel, Jan van Meerbeeck, Nico van Zandwijk, Cai Cun Zhou, Christian Manegold, Wieland Voigt, Eric Dominic Roessner
Although the effectiveness of screening for lung cancer remains controversial, it is a fact that the majority of lung cancers are diagnosed at an advanced stage outside of lung cancer screening programs. In 2013, the U.S. Preventive Services Task Force (USPSTF) revised its lung cancer screening recommendation, now supporting lung cancer screening by low-dose computed tomography (LDCT) in patients at high risk. This is also endorsed by many major medical societies and advocacy group stakeholders, however with different eligibility criteria...
September 26, 2017: Journal of Thoracic Oncology
Azam Hassanpour, Shirin Yousefian, Majid Askaripour, Fariba Sharififar, Massood Ezzatabadipour
Evaluation of protective effect of fennel on mouse ovary against the destructive effects of cyclophosphamide (CP) was the aim of this study. Adult female NMARI mice were randomly divided into six groups (n = 8): (A) negative control, (B) CP200 mg/kg, (C) fennel 400 mg/kg/day, (E, F, and D) that received fennel 200, 400 and 100 mg/kg/day respectively + CP200 mg/kg. Their ovary weight, volume, and diameter (WVD) were measured. Five micron sections were stained using the H&E method. The serum levels of oestrogen and progesterone were measured using ELISA kit...
2017: Toxicology Reports
Chongben Zhang, Emily M J Fennel, Christelle Douillet, Miroslav Stýblo
Environmental exposure to inorganic arsenic (iAs) has been shown to disturb glucose homeostasis, leading to diabetes. Previous laboratory studies have suggested several mechanisms that may underlie the diabetogenic effects of iAs exposure, including (i) inhibition of insulin signaling (leading to insulin resistance) in glucose metabolizing peripheral tissues, (ii) inhibition of insulin secretion by pancreatic β cells, and (iii) dysregulation of the methylation or expression of genes involved in maintenance of glucose or insulin metabolism and function...
September 26, 2017: Archives of Toxicology
Masumeh Ghazanfarpour, Elham Amini, Talat Khadivzadeh, Masoudeh Babakhanian, Bahareh Nouri, Hassan Rakhshandeh, Maliheh Afiat
OBJECTIVES: The goal of this study is to assess the effect of fennel on bone density. METHODS: This was a double-blind, randomized, placebo-controlled trial, which studied sixty eligible postmenopausal women, who were randomly assigned to fennel and placebo groups. Then, the dual energy X-ray absorptiometry was utilized to measure bone mineral density (BMD) and bone mineral content (BMC) of the spine, femoral neck, intertrochanter, and trochanter at the baseline and after three-month follow-up...
August 2017: Journal of Menopausal Medicine
Emiliano Brini, Christopher J Fennell, Marivi Fernandez-Serra, Barbara Hribar-Lee, Miha Lukšič, Ken A Dill
How are water's material properties encoded within the structure of the water molecule? This is pertinent to understanding Earth's living systems, its materials, its geochemistry and geophysics, and a broad spectrum of its industrial chemistry. Water has distinctive liquid and solid properties: It is highly cohesive. It has volumetric anomalies-water's solid (ice) floats on its liquid; pressure can melt the solid rather than freezing the liquid; heating can shrink the liquid. It has more solid phases than other materials...
October 11, 2017: Chemical Reviews
Mark R Zonfrillo, Mackenzie L Ramsay, Janette E Fennell, Amber Rollins
Objective There have been substantial reductions in motor vehicle crash-related child fatalities due to advances in legislation, public safety campaigns, and engineering. Less is known about nontraffic injuries and fatalities to children in and around motor vehicles. The objective of this study was to describe the frequency of various nontraffic incidents, injuries, and fatalities to children using a unique surveillance system and database. Methods Instances of nontraffic injuries and fatalities in the United States to children 0-14 years were tracked from January 1990 - December 2014 using a compilation of sources including media reports, individual accounts from families of affected children, medical examiner reports, police reports, child death review teams, coroner reports, medical professionals, legal professionals, and other various modes of publication...
September 21, 2017: Traffic Injury Prevention
Mohammad A Al-Tamimi, Bob Rastall, Ibrahim M Abu-Reidah
Background: Essential oils (EOs) are complex mixtures of several components gifted with a wide array of biological activities. The present research was designed to evaluate whether commercial essential oils could be effective by examining their in vitro antioxidant, cytotoxic, and apoptotic properties of nine commercially available EOs in Palestine, namely, African rue, basil, chamomile, fennel, fenugreek, ginger, spearmint, sage, and thyme, and to assure their effective use. Methods: The cytotoxic activity was determined using HT29-19(A) non-muco secreting and HT29-muco secreting (MS) cell lines...
October 25, 2016: Medicines (Basel, Switzerland)
Paweł Kwiatkowski, Magdalena Mnichowska-Polanowska, Agata Pruss, Helena Masiuk, Małgorzata Dzięcioł, Stefania Giedrys-Kalemba, Monika Sienkiewicz
An increase in the number of staphylococcal infections and carriers among medical staff has forced us to seek more and more effective antibacterial agents. Bacteria from the Staphylococcus genus possessing different mechanisms of resistance are the cause of nosocomial infections. The objective of our investigations was susceptibility of S. aureus strains isolated from nasal vestibule of medical students to fennel essential oil. The GC-MS analysis of fennel essential oil revealed eleven constituents among which a majority of trans-anethole (80%) was found...
November 2017: Burns: Journal of the International Society for Burn Injuries
S Amat, D Baines, T W Alexander
The objectives of this study were to develop a new assay for the evaluation of the antimicrobial activities of essential oils (EOs) in vapor-phase and to demonstrate the antimicrobial activities of commercial EOs against BRPs. To achieve the first objective, a microtube cap containing 100 μl of EO was embedded in an agar plate. An agar plug (diameter 13 mm) inoculated with a bacterial suspension containing10(8) CFU ml(-1) was then placed over the cap and incubated at 37 °C for 24 h. Subsequently, bacteria were recovered from the agar plug by immersion in 5 ml of broth for 10 min, followed by vortexing for 30 s, and the broths were then plated for enumeration...
September 15, 2017: Letters in Applied Microbiology
Zuobing Xiao, Jiaying Chen, Yunwei Niu, Feng Chen
The key odorants and the aroma profile of six fennel essential oils from different regions were investigated by using gas chromatography-olfactometry (GC-O), gas chromatography-mass spectrometry (GC-MS) and sensory evaluation. A total of 30 volatile compounds were determined by GC-O with aroma extract dilution analysis (AEDA) and the odor activity values (OAV) of them were calculated. Among these compounds, α-pinene, α-phellandrene, limonene, α-cubebene, β-caryophyllene, estragole, α-humulene, trans-anethole, δ-cadinene and p-anisaldehyde contributed greatly to the aroma of fennel essential oil due to their high flavor dilution (FD) factors and high OAVs...
September 15, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Masumeh Ghazanfarpour, Fatemeh Mohammadzadeh, Paymaneh Shokrollahi, Talat Khadivzadeh, Mona Najaf Najafi, Hamidreza Hajirezaee, Maliheh Afiat
The aim of this study was to evaluate the effect of Foeniculum vulgare (fennel) on anxiety and depression symptoms in postmenopausal women. This study was a double-blind, randomised, placebo-controlled trial, in which 60 eligible postmenopausal women were selected and then randomly assigned to fennel and placebo groups. Then, symptoms of anxiety and depression were measured using Hospital Anxiety and Depression Scale (HADS) and Zung's Self Rating Depression Scale (SDS). Following the intervention, the score of HADS (depression and anxiety subgroups) and SDS did not show any significant decrease in the sample under study...
September 11, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
Daniela Rupp, Nils Monserud, Bruno Langbehn, Mario Sauppe, Julian Zimmermann, Yevheniy Ovcharenko, Thomas Möller, Fabio Frassetto, Luca Poletto, Andrea Trabattoni, Francesca Calegari, Mauro Nisoli, Katharina Sander, Christian Peltz, Marc J Vrakking, Thomas Fennel, Arnaud Rouzée
Coherent diffractive imaging of individual free nanoparticles has opened routes for the in situ analysis of their transient structural, optical, and electronic properties. So far, single-shot single-particle diffraction was assumed to be feasible only at extreme ultraviolet and X-ray free-electron lasers, restricting this research field to large-scale facilities. Here we demonstrate single-shot imaging of isolated helium nanodroplets using extreme ultraviolet pulses from a femtosecond-laser-driven high harmonic source...
September 8, 2017: Nature Communications
Ehsaneh Khodadadi, Barat Ali Fakheri, Saeed Aharizad, Abbasali Emamjomeh, Majid Norouzi, Setsuko Komatsu
Fennel is attracted attention as a useful resource as researching medicinal plant for drought tolerance. To elucidate the response mechanism in drought-sensitive and -tolerant genotypes of fennel leaf, a gel-free/label-free proteomic technique was used. Fifty-day-old plants were subjected to drought stress for 60days. The relative water and proline contents were decreased and increased in sensitive genotypes, respectively; however, they were not a big change in tolerant genotypes. Photosynthesis was decreased in the sensitive genotypes under drought; however, it was increased in the tolerant genotype...
September 5, 2017: Biochimica et Biophysica Acta
Katie A Fennell, Mark A Dawson
No abstract text is available yet for this article.
September 8, 2017: Nature Medicine
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