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Narjis Naz, Aiza Kashif, Kinza Kanwal, Abdul Muqeet Khan, Mateen Abbas
The current research work aimed to access the contamination level of aflatoxins B1, B2, G1, and G2 in the household spices that are widely consumed in huge amounts. 200 different spice samples, 100 packed and 100 unpacked, were analyzed for the aflatoxins profile by HPLC with an incidence of 61.5% contamination out of which 53.66% samples exceed the EU limit. The results disclosed that the unpacked samples are more contaminated as compared to the packed samples except for white cumin seeds. Among packed and unpacked samples of spices, the maximum value of aflatoxins was detected in fennel, that is, 27...
2016: International Journal of Analytical Chemistry
Ana Clara Aprotosoaie, Irina-Iuliana Costache, Anca Miron
Anethole is the main fragrance and bioactive compound of anise, fennel, and star anise spices and more than other 20 plant species. It is widely used as flavor agent in food industry and other industries, in cosmetics, perfumery, and pharmaceuticals. In the last few years, various studies have revealed multiple beneficial effects of anethole for human health, such as anti-inflammatory, anticarcinogenic and chemopreventive, antidiabetic, immunomodulatory, neuroprotective, or antithrombotic, that are mediated by the modulation of several cell signaling pathways, mainly NF-kB and TNF-α signaling, and various ion channels...
2016: Advances in Experimental Medicine and Biology
Daniela Rupp, Leonie Flückiger, Marcus Adolph, Tais Gorkhover, Maria Krikunova, Jan Philippe Müller, Maria Müller, Tim Oelze, Yevheniy Ovcharenko, Benjamin Röben, Mario Sauppe, Sebastian Schorb, David Wolter, Rolf Mitzner, Michael Wöstmann, Sebastian Roling, Marion Harmand, Rolf Treusch, Mathias Arbeiter, Thomas Fennel, Christoph Bostedt, Thomas Möller
We studied the nanoplasma formation and explosion dynamics of single large xenon clusters in ultrashort, intense x-ray free-electron laser pulses via ion spectroscopy. The simultaneous measurement of single-shot diffraction images enabled a single-cluster analysis that is free from any averaging over the cluster size and laser intensity distributions. The measured charge state-resolved ion energy spectra show narrow distributions with peak positions that scale linearly with final ion charge state. These two distinct signatures are attributed to highly efficient recombination that eventually leads to the dominant formation of neutral atoms in the cluster...
October 7, 2016: Physical Review Letters
Ivana Generalić Mekinić, Ivica Blažević, Ivana Mudnić, Franko Burčul, Mia Grga, Danijela Skroza, Iva Jerčić, Ivica Ljubenkov, Mladen Boban, Mladen Miloš, Višnja Katalinić
Sea fennel, a rediscovered star of the coastal cuisine, has been investigated for its phytochemical profile and biological potential. Sea fennel flowers, stems and leaves were analyzed for essential oils (EOs) isolated by hydrodistillation, as well as non-volatiles obtained by ethanolic extraction. Limonene were found to be a dominant compound in EOs and ethanolic extracts; ranging from 57.5-74.2 % and 0.7-8.1 mg/g dry plant material, respectively. In addition total phenolic content was determined for ethanolic extracts...
July 2016: Journal of Food Science and Technology
Chloe Fletcher, Ingrid Flight, Janine Chapman, Kate Fennell, Carlene Wilson
OBJECTIVE: To provide an updated synthesis of the literature that investigates the self-reported information needs of people diagnosed with cancer across the cancer continuum. METHODS: We conducted a scoping review of the literature published from August 2003 to June 2015 and expanded an existing typology summarizing the information needs of people diagnosed with cancer. RESULTS: The majority of the included studies (n=104) focused on questions relevant to the diagnosis/active treatment phase of the cancer continuum (52...
October 12, 2016: Patient Education and Counseling
Anshu K Jain, Mary L Fennell, Anees B Chagpar, Hannah K Connolly, Ingrid M Nembhard
Effective communication is a requirement in the teamwork necessary for improved coordination to deliver patient-centered, value-based cancer care. Communication is particularly important when care providers are geographically distributed or work across organizations. We review organizational and teams research on communication to highlight psychological safety as a key determinant of high-quality communication within teams. We first present the concept of psychological safety, findings about its communication effects for teamwork, and factors that affect it...
October 18, 2016: Journal of Oncology Practice
Christian Manegold, Anne-Marie C Dingemans, Jhanelle E Gray, Kazuhiko Nakagawa, Marianne Nicolson, Solange Peters, Martin Reck, Yi-Long Wu, Odd Terje Brustugun, Lucio Crino, Enriqueta Felip, Dean Fennell, Pilar Garrido, Rudolf M Huber, Aurelien Marabelle, Marcin Moniuszko, Francoise Mornex, Silvia Novello, Mauro Papotti, Maurice Pérol, Egbert F Smit, Kostas Syrigos, Jan P van Meerbeeck, Nico van Zandwijk, James Chih-Hsin Yang, Caicun Zhou, Everett Vokes
Over the past few years, there have been considerable advances in the treatments available to patients with metastatic or locally advanced non-small cell lung cancer (NSCLC), particularly those who have progressed on or during first-line treatment. Some of the treatment options available to patients are discussed here, with a focus on checkpoint inhibitor immunotherapies (nivolumab and pembrolizumab) and antiangiogenic agents (bevacizumab, ramucirumab and nintedanib). It is hypothesised that combining immunotherapy with antiangiogenic treatment may have a synergistic effect and enhance the efficacy of both treatments...
October 8, 2016: Journal of Thoracic Oncology
Borbála Antal, Ákos Kuki, Lajos Nagy, Tibor Nagy, Miklós Zsuga, Márta M-Hamvas, Gábor Vasas, Sándor Kéki
Direct analysis in real time mass spectrometry (DART-MS) was applied as a rapid method for the discrimination of the spices and traditional medicines cumin (Cuminum cyminum L.), caraway (Carum carvi L.), and fennel (Foeniculum vulgare Mill.). The seeds of these plants were analyzed without sample preparation by DART ion source coupled with quadrupole time-of-flight (QTOF) tandem mass spectrometry. The relatively clean DART spectra showed characteristic patterns, fingerprints, for each herb. It was found that a marker compound can be assigned to each species that can identify unambiguously these plants...
2016: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
P-A Plötz, S P Polyutov, S D Ivanov, F Fennel, S Wolter, T Niehaus, Z Xie, S Lochbrunner, F Würthner, O Kühn
The quantum efficiency of light emission is a crucial parameter of supramolecular aggregates that can be tuned by the molecular design of the monomeric species. Here, we report on a strong variation of the fluorescence quantum yield due to different phases of aggregation for the case of a perylene bisimide dye. In particular, a change of the dominant aggregation character from H- to J-type within the first aggregation steps is found, explaining the observed dramatic change in quantum yield. This behaviour is rationalised by means of a systematic study of the intermolecular potential energy surfaces using the time-dependent density functional based tight-binding (TD-DFTB) method...
September 14, 2016: Physical Chemistry Chemical Physics: PCCP
Grant Wilson, Martin Trusler, Joseph Yao, Jet-Sing M Lee, Richard Graham, Niall Mac Dowell, Rosa Cuellar-Franca, George Dowson, Paul Fennell, Peter Styring, Jon Gibbins, Marco Mazzotti, Stefano Brandani, Christoph Müller, Ross Hubble
No abstract text is available yet for this article.
October 20, 2016: Faraday Discussions
Jet-Sing M Lee, Gary Rochelle, Peter Styring, Paul Fennell, Grant Wilson, Martin Trusler, Peter Clough, John Blamey, Matthew Dunstan, Niall MacDowell, Stephen Lyth, Joseph Yao, Thomas Hills, Matteo Gazzani, Patrick Brandl, Rahul Anantharaman, Stefano Brandani, Joshuah Stolaroff, Marco Mazzotti, Geoffrey Maitland, Christoph Müller, George Dowson, Jon Gibbins, Raffaella Ocone, Kyra Sedransk Campbell, María Erans, Liya Zheng, Daniel Sutter, Andac Armutlulu, Berend Smit
No abstract text is available yet for this article.
October 20, 2016: Faraday Discussions
Berend Smit, Richard Graham, Peter Styring, Joseph Yao, Peter Clough, Jet-Sing M Lee, Niall MacDowell, Stephen Lyth, Gary Rochelle, Thomas Hills, Grant Wilson, Camille Petit, Jasmin Kemper, Rosa Cuellar-Franca, George Dowson, Matteo Gazzani, Paul Fennell, Daniel Sutter, Colin Scholes, Adisa Azapagic, Robert Bell, Jon Gibbins, Marco Mazzotti, Geoffrey Maitland, Stefano Brandani, Raffaella Ocone, Mayte Mota-Martinez, Matthew Dunstan, Peiting Liang, Rahul Anantharaman, Lisa Joss, Joshuah Stolaroff
No abstract text is available yet for this article.
October 20, 2016: Faraday Discussions
Berend Smit, Peter Styring, Grant Wilson, Gary Rochelle, Felix Donat, Joseph Yao, Martin Trusler, Claire Adjiman, Stephen Lyth, Jet-Sing M Lee, Thomas Hills, Patrick Brandl, Matteo Gazzani, Rosa Cuellar-Franca, Paul Fennell, Daniel Sutter, Mai Bui, Colin Scholes, George Dowson, Jon Gibbins, Lisa Joss, Geoffrey Maitland, Stefano Brandani, Pelayo Garcia-Gutierrez, Yue Zhang, Christoph Müller, George Jackson, Raffaella Ocone, Lennart Joos, Robert Bell, Richard Graham
No abstract text is available yet for this article.
October 20, 2016: Faraday Discussions
A Young Han, Hui Su Lee, Geun Hee Seol
This study assessed the effects of essential oil of Foeniculum vulgare Mill. (fennel oil) and of trans-anethole, the main component of fennel oil, on extracellular Ca(2+)-induced store-operated Ca(2+) entry (SOCE) into vascular endothelial (EA) cells and their mechanisms of action. Components of fennel oil were analyzed by gas chromatography-mass spectrometry. Cytosolic Ca(2+) concentration ([Ca(2+)]c) in EA cells was determined using Fura-2 fluorescence. In the presence of extracellular Ca(2+), fennel oil significantly increased [Ca(2+)]c in EA cells; this increase was significantly inhibited by the Ca(2+) channel blockers La(3+) and nifedipine...
October 6, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Hiu-Fung Yuen, Ka-Kui Chan, Angela Platt-Higgins, El-Habib Dakir, Kyle B Matchett, Yusuf Ahmed Haggag, Puthen V Jithesh, Tanwir Habib, Ahmed Faheem, Fennell A Dean, Richard Morgan, Philip S Rudland, Mohamed El-Tanani
It has been shown previously that cancer cells with an activated oncogenic pathway, including Met activation, require Ran for growth and survival.Here, we show that knockdown of Ran leads to a reduction of Met receptor expression in several breast and lung cancer cell lines. This, in turn suppressed HGF expression and the Met-mediated activation of the Akt pathway, as well as cell adhesion, migration, and invasion. In a cell line model where Met amplification has previously been shown to contribute to gefitinib resistance, Ran knockdown sensitized cells to gefitinib-mediated inhibition of Akt and ERK1/2 phosphorylation and consequently reduced cell proliferation...
October 3, 2016: Oncotarget
Joo Hyun Nam, Dong-Ung Lee
BACKGROUND: Ultraviolet radiation exposure is the most important cause of extrinsic skin aging (photoaging), which causes skin wrinkling and hyperpigmentation. Although many factors are involved in the photoaging process, calcium release-activated calcium channel protein 1 (ORAI1) has been reported to be involved in UV-induced melanogenesis. OBJECTIVE: The aim of the present study was to find inhibitory effects of the extract of Foeniculum vulgare (fennel) fruits on ORAI1 ion channels and UV-induced melanogenesis in melanoma cells and to identify its active constituents...
September 28, 2016: Journal of Dermatological Science
S Michael Owens, Gerald T Pollard, James L Howard, Timothy R Fennell, Rodney W Snyder, F Ivy Carroll
JDTic is a potent and selective κ-opioid receptor (KOR) antagonist that reverses U50,488-induced diuresis in rats. It partitions into brain with a duration of action lasting for weeks. In a search for KOR antagonists that do not accumulate in the brain, we compared single doses of five methylated JDTic analogs (RTI-97, -194, -212, -240, and -241) for reversal of U50,488 diuresis and pharmacokinetic (PK) properties. All six compounds showed potent and selective KOR antagonism in a [(35)S]GTPγS binding assay...
October 4, 2016: ACS Chemical Neuroscience
K Kimura, P Babkevich, M Sera, M Toyoda, K Yamauchi, G S Tucker, J Martius, T Fennell, P Manuel, D D Khalyavin, R D Johnson, T Nakano, Y Nozue, H M Rønnow, T Kimura
In vortex-like spin arrangements, multiple spins can combine into emergent multipole moments. Such multipole moments have broken space-inversion and time-reversal symmetries, and can therefore exhibit linear magnetoelectric (ME) activity. Three types of such multipole moments are known: toroidal; monopole; and quadrupole moments. So far, however, the ME activity of these multipole moments has only been established experimentally for the toroidal moment. Here we propose a magnetic square cupola cluster, in which four corner-sharing square-coordinated metal-ligand fragments form a noncoplanar buckled structure, as a promising structural unit that carries an ME-active multipole moment...
October 4, 2016: Nature Communications
Timothy R Fennell, Ninell P Mortensen, Sherry R Black, Rodney W Snyder, Keith E Levine, Eric Poitras, James M Harrington, Christopher J Wingard, Nathan A Holland, Wimal Pathmasiri, Susan C J Sumner
Few investigations have been conducted on the disposition and fate of silver nanoparticles (AgNP) in pregnancy. The distribution of a single dose of polyvinylpyrrolidone (PVP)-stabilized AgNP was investigated in pregnant rats. Two sizes of AgNP, 20 and 110 nm, and silver acetate (AgAc) were used to investigate the role of AgNP diameter and particle dissolution in tissue distribution, internal dose and persistence. Dams were administered AgNP or AgAc intravenously (i.v.) (1 mg kg(-1) ) or by gavage (p...
October 3, 2016: Journal of Applied Toxicology: JAT
Myles Fennell, Kaylene J Simpson
No abstract text is available yet for this article.
October 2016: Assay and Drug Development Technologies
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