keyword
MENU ▼
Read by QxMD icon Read
search

Mycotoxins

keyword
https://www.readbyqxmd.com/read/28720287/occurrence-toxicity-bioaccessibility-and-mitigation-strategies-of-beauvericin-a-minor-fusarium-mycotoxin
#1
REVIEW
C Luz, F Saladino, F B Luciano, J Mañes, G Meca
Emerging Fusarium mycotoxins include the toxic secondary metabolites fusaproliferin, enniatins, beauvericin (BEA), and moniliform. BEA is produced by some entomo- and phytopathogenic Fusarium species and occurs naturally on corn and corn-based foods and feeds infected by Fusarium spp. BEA has shown various biological activities (antibacterial, antifungal, and insecticidal) and possesses toxic activity, including the induction of apoptosis, increase cytoplasmic calcium concentration and lead to DNA fragmentation in mammalian cell lines...
July 15, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28718805/emerging-fusarium-and-alternaria-mycotoxins-occurrence-toxicity-and-toxicokinetics
#2
REVIEW
Sophie Fraeyman, Siska Croubels, Mathias Devreese, Gunther Antonissen
Emerging Fusarium and Alternaria mycotoxins gain more and more interest due to their frequent contamination of food and feed, although in vivo toxicity and toxicokinetic data are limited. Whereas the Fusarium mycotoxins beauvericin, moniliformin and enniatins particularly contaminate grain and grain-based products, Alternaria mycotoxins are also detected in fruits, vegetables and wines. Although contamination levels are usually low (µg/kg range), higher contamination levels of enniatins and tenuazonic acid may occasionally occur...
July 18, 2017: Toxins
https://www.readbyqxmd.com/read/28718025/reduction-of-individual-or-combined-toxicity-of-fumonisin-b1-and-zearalenone-via-dietary-inclusion-of-organo-modified-nano-montmorillonite-in-rats
#3
Aziza A El-Nekeety, Ahmed A El-Kady, Khaled G Abdel-Wahhab, Nabila S Hassan, Mosaad A Abdel-Wahhab
Fusarium mycotoxins are nature environmental contaminants worldwide in animal feed and human food resulting in a serious health risk. The present study aimed to evaluate the potential role of organo-modified nano-montmorillonite (OMNM) against the health risk and the oxidative stress resulted from the exposure of fumonisin (FB1) and zearalenone (ZEN) individually and in combination in rats. Eight groups of female Sprague Dawley rats were treated orally for 3 weeks including the control group, FB1 alone-treated group (50 mg/kg b...
July 17, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28714869/the-occurrence-of-zearalenone-in-south-korean-feedstuffs-between-2009-and-2016
#4
Hansub Chang, Woori Kim, Ju-Hee Park, Dongho Kim, Choong-Ryeol Kim, Soohyun Chung, Chan Lee
Mycotoxins produced by Fusarium plant pathogen species have harmful effects on humans and livestock by natural contamination in food and feed. Zearalenone, one of the well-known Fusarium mycotoxins, causes hyperestrogenism and toxicosis resulting in reproductive dysfunction in animals. This study investigated the occurrence of zearalenone in feedstuffs (compound feeds, feed ingredients) between 2009 and 2016 in South Korea to obtain information on zearalenone contamination in feeds for management. A total of 653 animal feed samples (494 compound feeds, 159 feed ingredients) produced domestically were sampled five times from 2009 to 2016 (2009, 2010, 2012, 2014, and 2016) from feed factories in South Korea...
July 15, 2017: Toxins
https://www.readbyqxmd.com/read/28710020/nrf2-deficiency-exacerbates-ochratoxin-a-induced-toxicity-in-vitro-and-in-vivo
#5
Agnieszka Loboda, Anna Stachurska, Mateusz Sobczak, Paulina Podkalicka, Olga Mucha, Alicja Jozkowicz, Jozef Dulak
Several mechanisms are postulated to be responsible for nephrotoxic and nephrocarcinogenic activities of mycotoxin and food contaminant, ochratoxin A (OTA). Although Nrf2 transcription factor was suggested to be involved in OTA-mediated renal injury, comprehensive study evaluating the effect of OTA toxicity in Nrf2 knock-out mice with special regard to sex-dependency has not been performed yet. Our results clearly show exacerbated OTA toxicity in porcine tubular epithelial cells after shRNA-mediated Nrf2 inhibition as well as in proximal tubular cells isolated from Nrf2(-/-)male mice in comparison to cells derived from their wild-type counterparts...
July 11, 2017: Toxicology
https://www.readbyqxmd.com/read/28708102/ability-of-soil-isolated-actinobacterial-strains-to-prevent-bind-and-biodegrade-ochratoxin-a
#6
Rachelle El Khoury, Florence Mathieu, Ali Atoui, Hiba Kawtharani, Anthony El Khoury, Charbel Afif, Richard G Maroun, André El Khoury
Ochratoxin A (OTA) is one of the most important mycotoxins, and contaminates several agricultural products, particularly cereals, grapes, maize, barley, spices and coffee. The aim of this project was to reduce the levels of OTA by supplementing the artificially contaminated solutions with seven strains of actinobacteria (AT10, AT8, SN7, MS1, ML5, G10 and PT1) in order to evaluate their capacity for binding and metabolizing the OTA, as well as their ability to reduce the expression of the genes responsible for its production in A...
July 14, 2017: Toxins
https://www.readbyqxmd.com/read/28708032/comparison-of-a-newly-developed-liquid-chromatography-with-tandem-mass-spectrometry-method-and-enzyme-linked-immunosorbent-assay-for-detection-of-multiple-mycotoxins-in-red-pepper-powder
#7
Sunyoung Kim, Sanghee Lee, Tae-Gyu Nam, Dongwon Seo, Miyoung Yoo
In this study, we aimed to establish a method for determination of multiple mycotoxins such as aflatoxins, ochratoxin A, and zearalenone in red pepper powder samples based on the quick, easy, cheap, effective, rugged, and safe (QuEChERS) approach for extraction and cleanup, with detection and quantification by high-performance liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) in both positive- and negative-ion modes. The developed LC-MS/MS analytical method was compared with an enzyme-linked immunosorbent assay (ELISA) to improve the reliability of our developed method...
July 14, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28707037/variability-of-composition-and-effects-of-essential-oils-from-rhanterium-adpressum-coss-durieu-against-mycotoxinogenic-fusarium-strains
#8
Fatiha Elhouiti, Djilali Tahri, Djalila Takhi, Mohamed Ouinten, Christian Barreau, Marie-Noëlle Verdal-Bonnin, Isabelle Bombarda, Mohamed Yousfi
The antifungal potency of the essential oils of Rhanterium adpressum was evaluated against four mycotoxigenic strains of the genus Fusarium. The essential oils were obtained, separately, by hydro-distillation of the aerial parts of R. adpressum (leaves and flowers). The parts were collected during the period of bloom (3 months) for 3 years. The GC-MS analysis revealed thirty-six compounds for the essential oils, divided into four classes of chemical compounds, with variable percentages according to the month of extraction...
July 13, 2017: Archives of Microbiology
https://www.readbyqxmd.com/read/28699257/effects-of-ochratoxin-a-on-er-stress-mapk-signaling-pathway-and-autophagy-of-kidney-and-spleen-in-pigs
#9
Fang Gan, Lili Hou, Yajiao Zhou, Yunhuan Liu, Da Huang, Xingxiang Chen, Kehe Huang
Ochratoxin A (OTA), a worldwide mycotoxin found in food and feeds, is a potent nephrotoxin and immunotoxin in animals and humans. This research was conducted to evaluate whether endoplasmic reticulum (ER) stress, MAPK signaling pathway and autophagy were induced by OTA in kidney and spleen of pigs. Twenty-seven crossbred pigs randomly allocated to 3 groups were fed for 42 days ad libitum a basal diet without (Con group, 0.00 μg OTA/kg) and with supplementation of OTA at 400 (OTA-L group) and 800 μg/kg (OTA-H group)...
July 12, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/28698507/risk-assessment-of-mycotoxins-in-stored-maize-grains-consumed-by-infants-and-young-children-in-nigeria
#10
Modupeade C Adetunji, Olusegun O Atanda, Chibundu N Ezekiel
Maize is a major complimentary food for infants (0-4years) and young children (5-12years) in Nigeria. In this study, we assessed the risk of exposure of infants and young children (IYC) to some major mycotoxins in stored maize grains from five agro-ecological zones of Nigeria. The probable daily intake approach was employed to determine exposure to five mycotoxins while the margin of exposure (MOE) and population at risk of primary hepatocellular carcinoma approaches were used to characterize the risk of consuming aflatoxin contaminated maize...
July 10, 2017: Children
https://www.readbyqxmd.com/read/28698479/antifungal-microbial-agents-for-food-biopreservation-a-review
#11
REVIEW
Marcia Leyva Salas, Jérôme Mounier, Florence Valence, Monika Coton, Anne Thierry, Emmanuel Coton
Food spoilage is a major issue for the food industry, leading to food waste, substantial economic losses for manufacturers and consumers, and a negative impact on brand names. Among causes, fungal contamination can be encountered at various stages of the food chain (e.g., post-harvest, during processing or storage). Fungal development leads to food sensory defects varying from visual deterioration to noticeable odor, flavor, or texture changes but can also have negative health impacts via mycotoxin production by some molds...
July 8, 2017: Microorganisms
https://www.readbyqxmd.com/read/28697933/a-simple-method-for-point-of-need-extraction-concentration-and-rapid-multi-mycotoxin-immunodetection-in-feeds-using-aqueous-two-phase-systems
#12
Ruben R G Soares, Ana M Azevedo, Pedro Fernandes, Virginia Chu, João P Conde, M Raquel Aires-Barros
The rapid detection of mycotoxins in feed samples is becoming an increasingly relevant challenge for the food production sector, in order to effectively enforce current regulations and assure food and feed safety. To achieve rapid mycotoxin detection, several biosensing strategies have been published, many reaching assay times of the order of a few minutes. However, the vast majority of these rely on sample preparation based on volatile organic solvents, often comprising complex multi-step procedures and devoid of clean-up and/or concentration effects...
July 5, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28695994/comparative-efficacy-of-bentonite-clay-activated-charcoal-and-trichosporon-mycotoxinivorans-in-regulating-the-feed-to-tissue-transfer-of-mycotoxins
#13
Sheraz Ahmed Bhatti, Muhammad Zargham Khan, Zahoor Ul Hassan, Muhammad Kashif Saleemi, Muhammad Saqib, Aisha Khatoon, Masood Akhter
BACKGROUND: Mycotoxins contamination in animal products and by-product is a persistent threat to food and feed industry. The present study was designed to evaluate the comparative inhibitory effects of bentonite (BN), activated charcoal (AC) and a newly discovered yeast Trichosporon mycotoxinivorans (TM) against feed-to-tissue transfer of mycotoxins. RESULTS: A dose dependent increase as determined by HPLC, in the residues of AFB1 and OTA was exhibited in the groups of birds fed AFB1 and OTA alone...
July 11, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28695844/the-structure-of-a-complex-of-the-lactonohydrolase-zearalenone-hydrolase-with-the-hydrolysis-product-of-zearalenone-at-1-60%C3%A2-%C3%A3-resolution
#14
Qi Qi, Wen Jing Yang, Hu Jian Zhou, Deng Ming Ming, Kai Lei Sun, Tian Yu Xu, Xiao Jian Hu, Hong Lv
Zearalenone hydrolase (ZHD) is an α/β-hydrolase that detoxifies and degrades the lactone zearalenone (ZEN), a naturally occurring oestrogenic mycotoxin that contaminates crops. Several apoenzyme and enzyme-substrate complex structures have been reported in the resolution range 2.4-2.6 Å. However, the properties and mechanism of this enzyme are not yet fully understood. Here, a 1.60 Å resolution structure of a ZHD-product complex is reported which was determined from a C-terminally His6-tagged ZHD crystal soaked with 2 mM ZEN for 30 min...
July 1, 2017: Acta Crystallographica. Section F, Structural Biology Communications
https://www.readbyqxmd.com/read/28691595/application-of-hydrolases-and-probiotic-pediococcus-acidilactici-baltbio01-strain-for-cereal-by-products-conversion-to-bioproduct-for-food-feed
#15
Elena Bartkiene, Vadims Bartkevics, Vita Krungleviciute, Grazina Juodeikiene, Daiva Zadeike, Violeta Baliukoniene, Bronius Bakutis, Rasa Zelvyte, Antonello Santini, Dalia Cizeikiene
The aim of this study was to apply the enzymatic treatment and fermentation by Pediococcus acidilactici BaltBio01 strain for industrial cereal by-products conversion to food/feed bioproducts with high amount of probiotic lactic acid bacteria (LAB). LAB propagated in potato media and spray-dried remained viable during 12 months (7.0 log10 cfu/g) of storage and was used as a starter for cereal by-products fermentation. The changes of microbial profile, biogenic amines (BAs), mycotoxins, lactic acid (L(+)/D(-)), lignans and alkylresorcinols (ARs) contents in fermented cereal by-product were analysed...
July 9, 2017: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/28690182/functional-characterization-of-a-soluble-nadph-cytochrome-p450-reductase-from-fusarium-graminearum
#16
Thomas Etzerodt, Karl Wetterhorn, Giuseppe Dionisio, Ivan Rayment
Fusarium head blight is a devastating disease in wheat caused by some fungal pathogens of the Fusarium genus mainly F. graminearum, due to accumulation of toxic trichothecenes. Most of the trichothecene biosynthetic pathway has been mapped, although some proteins of the pathway remain uncharacterized, including an NADPH-cytochrome P450 reductase. We subcloned a F. graminearum cytochrome P450 reductase that might be involved in the trichothecene biosynthesis. It was expressed heterologously in E. coli as N-terminal truncated form with an octahistidine tag for purification...
July 6, 2017: Protein Expression and Purification
https://www.readbyqxmd.com/read/28689064/transfer-of-zearalenone-to-the-reproductive-system-of-female-rainbow-trout-spawners-a-potential-risk-for-aquaculture-and-fish-consumers
#17
Maciej Woźny, Kazimierz Obremski, Tomasz Zalewski, Maren Mommens, Alicja Łakomiak, Paweł Brzuzan
To investigate whether ZEN transfers from the alimentary tract of fish to the somatic cells of ovaries or the oocytes, mature females of rainbow trout were orally exposed to ZEN at a dose of 1 mg·kg(-)(1) body mass. At sampling times of 2, 6, 12, 24, 48, and 96 h, tissues of the fish (intestine, liver, ovaries, oocytes, muscles, and plasma) were extracted to determine the concentration of ZEN and its metabolites using immunoaffinity columns and HPLC-FLD. Our results confirm that ZEN is transferred from the alimentary tract to the reproductive system of the fish, and indicate that the mycotoxin concentrates in the somatic cells of the ovaries...
July 5, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28688805/low-level-of-ochratoxin-a-affects-genome-wide-expression-in-kidney-of-pig
#18
Daniela Eliza Marin, Cornelia Braicu, Mihai Alexandru Gras, Gina Cecilia Pistol, Roxana Cojocneanu Petric, Ioana Berindan Neagoe, Mihai Palade, Ionelia Taranu
Ochratoxin A (OTA) is a mycotoxin produced by fungus belonging to Aspergillus and Penicillium genra. The aim of the present paper was to investigate if a low concentration OTA has toxic effect in pigs. Twelve piglets were fed with a control or an OTA (0.05 mg/kg feed) contaminated diet. After 30 days, animals were slaughtered and samples of blood and kidney were used for further analyses. The mycotoxin analyses showed a significant higher (6.25 times) concentration of OTA in the kidney of OTA intoxicated piglets than in control ones...
July 5, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28687259/why-does-finland-have-the-highest-dementia-mortality-rate-environmental-factors-may-be-generalizable
#19
REVIEW
Arnold R Eiser
Finland has the highest death rate from dementia in the world and its environmental features can be instructive in understanding hidden causes of dementia. Environmental factors there include: 1) a climate that is both very cold and humid resulting in housing frequently harboring molds that are capable of producing a neurotoxic mycotoxin 2) the Gulf of Finland as well as Finnish lakes harbor cyanobacteria that produce the neurotoxin, beta-N-methyl amino-L-alanine, known to cause dementia and related disorders 3) the aforementioned toxins can be potentiated by the presence of mercury and methyl mercury which can be found in Finnish waters 4) soil in Finland is naturally low in selenium and selenium deficiency may reduce the quantity and effectiveness of glutathione's ability to protect against neurotoxins...
July 4, 2017: Brain Research
https://www.readbyqxmd.com/read/28687037/biodegradation-and-biodetoxification-of-fusarium-mycotoxins-by-sphaerodes-mycoparasitica
#20
Seon Hwa Kim, Vladimir Vujanovic
A fungus Sphaerodes mycoparasitica SMCD 2220-01 is a host specific mycoparasite against plant pathogenic Fusarium species. Fusarium spp. are producing a plethora of mycotoxins including zearalenone (ZEN), deoxynivalenol (DON) and its acetylated derivatives, 3-acetyl-deoxynivalenol (3-ADON) and 15-acetyl-deoxynivalenol (15-ADON). The SMCD 2220-01 strain substantially reduced DON, 3-ADON, 15-ADON, and ZEN production capacity in co-culture system. Degradation and detoxification of the pure mycotoxins were also achieved when exposed to SMCD 2220-01 in shake flasks...
December 2017: AMB Express
keyword
keyword
53886
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"