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https://www.readbyqxmd.com/read/29666470/glucose-regulated-protein-78-is-essential-for-cardiac-myocyte-survival
#1
Xiaoding Wang, Xukun Bi, Guangyu Zhang, Yingfeng Deng, Xiang Luo, Lin Xu, Philipp E Scherer, Anwarul Ferdous, Guosheng Fu, Thomas G Gillette, Amy S Lee, Xuejun Jiang, Zhao V Wang
Secretory and transmembrane proteins rely on proper function of the secretory pathway for folding, posttranslational modification, assembly, and secretion. Accumulation of misfolded proteins in the endoplasmic reticulum (ER) stimulates the unfolded protein response (UPR), which communicates between the ER and other organelles to enhance ER-folding capacity and restore cellular homeostasis. Glucose-regulated protein of 78 kDa (GRP78), an ER-resident protein chaperone, is a master regulator of all UPR signaling branches...
April 17, 2018: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29666185/hepatocyte-nuclear-receptor-shp-suppresses-inflammation-and-fibrosis-in-a-mouse-model-of-nonalcoholic-steatohepatitis
#2
An Zou, Nancy Magee, Fengyan Deng, Sarah Lehn, Cuncong Zhong, Yuxia Zhang
Nonalcoholic fatty liver disease (NAFLD) is a burgeoning health problem worldwide, ranging from nonalcoholic fatty liver (NAFL, steatosis without hepatocellular injury) to the more aggressive nonalcoholic steatohepatitis (NASH, steatosis with ballooning, inflammation, or fibrosis). Although many studies have greatly contributed to the elucidation of NAFLD pathogenesis, the disease progression from NAFL to NASH still remains incompletely understood. Nuclear receptor small heterodimer partner (Nr0b2, SHP) is a transcriptional regulator critical for the regulation of bile acid, glucose, and lipid metabolism...
April 17, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29666155/sil1-the-er-hsp70-co-chaperone-plays-a-critical-role-in-maintaining-skeletal-muscle-proteostasis-and-physiology
#3
Viraj P Ichhaporia, Jieun Kim, Kanisha Kavdia, Peter Vogel, Linda Horner, Sharon Frase, Linda M Hendershot
Mutations in SIL1 , a co-factor for the endoplasmic reticular (ER) chaperone BiP, cause Marinesco-Sjögren syndrome (MSS), an autosomal recessive disorder. Using a mouse model, we characterized molecular aspects of the progressive myopathy associated with MSS. Proteomic-profiling of quadriceps at the onset of myopathy revealed that SIL1 deficiency affected multiple pathways critical to muscle physiology. We observed an increase in ER chaperones prior to the onset of muscle weakness, which was complemented by up-regulation of multiple components of cellular protein degradation pathways...
April 9, 2018: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/29665823/exposure-to-concentrated-ambient-pm-2-5-alters-the-composition-of-gut-microbiota-in-a-murine-model
#4
Wanjun Wang, Ji Zhou, Minjie Chen, Xingke Huang, Xiaoyun Xie, Weihua Li, Qi Cao, Haidong Kan, Yanyi Xu, Zhekang Ying
BACKGROUND: Exposure to ambient fine particulate matter (PM2.5 ) correlates with abnormal glucose homeostasis, but the underlying biological mechanism has not been fully understood. The gut microbiota is an emerging crucial player in the homeostatic regulation of glucose metabolism. Few studies have investigated its role in the PM2.5 exposure-induced abnormalities in glucose homeostasis. METHODS: C57Bl/6J mice were exposed to filtered air (FA) or concentrated ambient PM2...
April 17, 2018: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/29665822/toxoplasma-gondii-dense-granule-protein-15-induces-apoptosis-in-choriocarcinoma-jeg-3-cells-through-endoplasmic-reticulum-stress
#5
Wei Wei, Fangfang Zhang, He Chen, Yuanyuan Tang, Tian Xing, Qingli Luo, Li Yu, Jian Du, Jilong Shen, Linjie Zhang
BACKGROUND: Toxoplasma gondii, a single-celled parasite commonly found in mammals, has been shown to induce trophoblast cell apoptosis and subsequently cause fetal damage and abortion. Although dense granule protein 15 (GRA15) has been identified as a key component in innate immunity to T. gondii infection and its pathogenesis, its role in host cell apoptosis remains unclarified. METHODS: Type II GRA15 (GRA15II ) cDNA was inserted into a plasmid encoding enhanced green fluorescent protein (pEGFP)...
April 17, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29665363/isoquercetin-ameliorates-hyperglycemia-and-regulates-key-enzymes-of-glucose-metabolism-via-insulin-signaling-pathway-in-streptozotocin-induced-diabetic-rats
#6
Muthukumaran Jayachandran, Tongze Zhang, Kumar Ganesan, Baojun Xu, Stephen Sum Man Chung
Among the foremost common flavonoids within the human diet, quercetin glycosides possess neuroprotective, cardioprotective, anti-oxidative, chemopreventive, and anti-allergic properties. Isoquercetin is one such promising candidate with anti-diabetic potential. However, complete studies of its molecular action on insulin signaling pathway and carbohydrate metabolizing enzymes remain unclear. Hence, we have designed this study to accumulate the experimental evidence in support of anti-diabetic effects of isoquercetin...
April 14, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29664675/knockout-of-glucose-transporter-glut6-has-minimal-effects-on-whole-body-metabolic-physiology-in-mice
#7
Frances L Byrne, Ellen M Olzomer, Robert Brink, Kyle L Hoehn
Glucose transporter 6 (GLUT6) is a member of the facilitative glucose transporter family. GLUT6 is up-regulated in several cancers, but is not widely expressed in normal tissues. Previous studies have shown that GLUT6 knockdown kills endometrial cancer cells that express elevated levels of the protein. However, whether GLUT6 represents a viable anti-cancer drug target is unclear because the role of GLUT6 in normal metabolic physiology is unknown. Herein we generated GLUT6 knockout mice to determine how loss of GLUT6 affected whole body glucose homeostasis and metabolic physiology...
April 17, 2018: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29664658/downregulation-of-glut3-promotes-apoptosis-and-chemosensitivity-of-acute-myeloid-leukemia-cells-via-egfr-signaling
#8
Yan Zhuang, Jing Zhao, Xi Xu, Laixi Bi
BACKGROUND: Glucose transporter 3 (GLUT3) plays an important role in tumor progression and drug resistance in numerous malignancies, including acute myeloid leukemia (AML). However, the effect of GLUT3 silencing on treatment of AML remains poorly understood. The purpose of this study was to investigate role of GLUT3 in proliferation and chemosensitivity of AML and its underlying mechanisms. METHODS: The siRNA transfection was conducted using LipofectamineTM 2000...
February 1, 2018: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/29663989/-high-mobility-group-box-1-contributes-to-the-endoplasmic-reticulum-stress-of-liver-in-rats-with-trauma
#9
Qingjie Zhang, Jianfeng Lu, Xuehao Li, Yichang Liu, Guoqing Liu, Xinhua Han, Zhenyong Gu
OBJECTIVE: To investigate the role of high mobility group box 1 (HMGB1) in hepatic endoplasmic reticulum stress (ERS) in rats with trauma. METHODS: Sixty SPF Sprague-Dawley (SD) rats were randomly divided into groups (n = 6). The rat model of liver injury following traumatic stress was established by continuous compressing the bilateral hind-limbs of rats for 3 hours and then intermittent compressing and decompressing for 30 minutes respectively three times with standard weight of 15 kg...
April 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29663987/-effects-of-hippo-signaling-on-anti-oxidative-stress-of-mesenchymal-stem-cells-in-vitro
#10
Lang Li, Liang Dong, Jiaojie Hui, Fei Gao, Qiuhui Wang, Lan Yang, Jiangqian Zhang, Jie Yan
OBJECTIVE: To explore the effects of Hippo signaling on anti-oxidative stress of mouse marrow mesenchymal stem cells (mMSCs) in vitro. METHODS: mMSCs derived from C57BL/6 mice were identified using fluorescence-activated cell sorting analysis and the capabilities of osteogenic, chondrogenic and adipogenic differentiation were evaluated. 2-deoxy-D-glucose (2-DG) or XMU-MP-1 was used to modulate Hippo signaling. Oxidative stress was induced by H2 O2 treatment and the effect of oxidative stress induced by H2 O2 on survival of mMSCs was evaluated using methyl thiazolyl tetrazolium (MTT) assay...
April 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29663740/mirna-223-regulates-ischemic-neuronal-injury-by-targeting-the-type-1-insulin-like-growth-factor-receptor-igf1r
#11
She-Jun Feng, Xue-Qiang Zhang, Jun-Tao Li, Xiao-Min Dai, Fei Zhao
Cerebral ischemia injury seriously endangers human health and its molecular mechanism is still not fully understood. microRNA-223 (miR-223) has been reported to be involved in many physiological functions but the specific role of miRNA-223 in ischemic neuronal injury is still unclear. An oxygen-glucose deprivation and simulated reperfusion (OGD/R) model was constructed here to investigate the possible role miR-223 played in ischemic neuronal injury. The expression of miRNA-223 in the OGD/R model and its effect on cell proliferation were studied by qPCR and CCK8 assay...
2018: Folia Neuropathologica
https://www.readbyqxmd.com/read/29663508/expression-of-endoplasmic-reticulum-stress-protein-in-rabbit-condyle-cartilage-following-anterior-disc-displacement
#12
Ting Xu, Zhiyuan Gu, Huiling Wu, Hua Yao, Guohua Wang
OBJECTIVE: Anterior disc displacement (ADD) is a most common subtype of temporomandibular disorders (TMD), which is promoted by chondrocytes apoptosis. However, the signaling pathways that trigger apoptosis are still unknown. The aim of this study was to investigate the expression of endoplasmic reticulum (ER) stress related proteins in the condylar cartilage of rabbits following ADD. METHODS: Sixty healthy adult rabbits were randomly assigned to the experimental and sham-operated control groups (n=12)...
April 16, 2018: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/29663500/knockdown-of-lncrna-uca1-suppresses-chemoresistance-of-pediatric-aml-by-inhibiting-glycolysis-through-the-microrna-125a-hexokinase-2-pathway
#13
Yuan Zhang, Yufeng Liu, Xueju Xu
Dysregulation of lncRNAs is implicated in chemoresistance in varieties of tumor including acute myeloid leukemia (AML). LncRNA urothelial carcinoma-associated 1 (UCA1) was reported to play an oncogenic role in AML. However, whether UCA1 was involved in chemoresistance in pediatric AML remains unclear. UCA1 expression in AML patients after adriamycin (ADR)-based chemotherapy and ADR-resistant AML cells was examined by qRT-PCR. The effects of UCA1 on the cytotoxicity of ADR and glycolysis were evaluated by MTT assay and measuring the glucose consumption and lactate production in HL60 and HL60/ADR cells, repectively...
April 16, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29663377/ubiad1-protects-against-oxygen-glucose-deprivation-reperfusion-induced-multiple-subcellular-organelles-injury-through-pi3k-akt-pathway-in-n2a-cells
#14
Yan Huang, Zhiping Hu
Cerebral ischemia/reperfusion-induced injury plays a significant role in the development of multi-subcellular organelles injury after ischemic stroke. UBIAD1 was discovered originally as a potential tumor suppressor protein. Recently, analysis of UBIAD1 has indicated it is a prenyltransferase enzyme for both non-mitochondrial CoQ10 and vitamin K2 production. Further, UBIAD1 has been localized to multiple subcellular organelles. Particularly, UBIAD1 plays an important role in the regulation of oxidative stress, apoptosis and cell proliferation, cholesterol and lipid metabolism, which was closely associated with the cerebral ischemic/reperfusion mechanism...
April 16, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29663292/the-potential-role-of-sglt2-inhibitors-in-the-treatment-of-type-1-diabetes-mellitus
#15
Hadi Fattah, Volker Vallon
Type 1 diabetes mellitus is a difficult disease to treat due to the relative paucity of therapeutic options other than injectable insulin. The latter, however, can induce hypoglycemia, which has been linked to enhanced cardiovascular risk. Sodium glucose cotransporter 2 (SGLT2) inhibitors are a new class of oral anti-hyperglycemic medications that do not increase the hypoglycemia risk and are US Food and Drug Administration (FDA) approved in type 2 diabetes mellitus. SGLT2 inhibitors may also be of benefit in type 1 diabetic patients, in addition to insulin, although they have not yet been approved for this indication...
April 16, 2018: Drugs
https://www.readbyqxmd.com/read/29662780/distinct-metabolic-programs-induced-by-tgf-%C3%AE-1-and-bmp2-in-human-articular-chondrocytes-with-osteoarthritis
#16
Cuicui Wang, Richard M Silverman, Jie Shen, Regis J O'Keefe
Objectives: Cellular energy metabolism is important for the function of all tissues, including cartilage. Recent studies indicate that superficial and deep subpopulations of articular chondrocytes (ACs) have distinct metabolic profiles. At the cellular and molecular level, osteoarthritis (OA) is characterised by alteration from a healthy homoeostatic state towards a catabolic state. Several molecular pathways, including transforming growth factor beta (TGF-β) and bone morphogenetic protein (BMP) signalling, have been identified as critical players in the pathogenesis and progression of OA...
January 2018: Journal of Orthopaedic Translation
https://www.readbyqxmd.com/read/29662449/multiple-transceptors-for-macro-and-micro-nutrients-control-diverse-cellular-properties-through-the-pka-pathway-in-yeast-a-paradigm-for-the-rapidly-expanding-world-of-eukaryotic-nutrient-transceptors-up-to-those-in-human-cells
#17
REVIEW
Fenella Steyfkens, Zhiqiang Zhang, Griet Van Zeebroeck, Johan M Thevelein
The nutrient composition of the medium has dramatic effects on many cellular properties in the yeast Saccharomyces cerevisiae . In addition to the well-known specific responses to starvation for an essential nutrient, like nitrogen or phosphate, the presence of fermentable sugar or a respirative carbon source leads to predominance of fermentation or respiration, respectively. Fermenting and respiring cells also show strong differences in other properties, like storage carbohydrate levels, general stress tolerance and cellular growth rate...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29662125/netrin-1-promotes-diabetic-corneal-wound-healing-through-molecular-mechanisms-mediated-via-the-adenosine-2b-receptor
#18
Yangyang Zhang, Peng Chen, Guohu Di, Xia Qi, Qingjun Zhou, Hua Gao
Netrins are secreted chemoattractants with the roles in axon guidance, cell migration and epithelial plasticity. In the present study, we investigated the roles of netrin-1 in the regulation of corneal epithelial wound healing, inflammation response and nerve fiber regeneration in diabetic mice and cultured corneal epithelial cells. In diabetic mice, the expression of netrin-1 was decreased when compared with that of normal mice. Furthermore, high glucose blocked the wounding-induced up-regulation of netrin-1 expression in corneal epithelial cells...
April 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29662084/hoxa9-inhibits-hif-1%C3%AE-mediated-glycolysis-through-interacting-with-crip2-to-repress-cutaneous-squamous-cell-carcinoma-development
#19
Liang Zhou, Yinghui Wang, Meijuan Zhou, Ying Zhang, Pengfei Wang, Xiaoxing Li, Jing Yang, Hongmei Wang, Zhenhua Ding
Glycolytic reprogramming is a typical feature of many cancers; however, key regulators of glucose metabolism reengineering are poorly understood, especially in cutaneous squamous cell carcinoma (cSCC). Here, Homeobox A9 (HOXA9), a direct target of onco-miR-365, is identified to be significantly downregulated in cSCC tumors and cell lines. HOXA9 acts as a tumor suppressor and inhibits glycolysis in cSCC in vitro and in vivo by negatively regulating HIF-1α and its downstream glycolytic regulators, HK2, GLUT1 and PDK1...
April 16, 2018: Nature Communications
https://www.readbyqxmd.com/read/29662010/metabolic-features-of-multiple-myeloma
#20
REVIEW
Chaima El Arfani, Kim De Veirman, Ken Maes, Elke De Bruyne, Eline Menu
Cancer is known for its cellular changes contributing to tumour growth and cell proliferation. As part of these changes, metabolic rearrangements are identified in several cancers, including multiple myeloma (MM), which is a condition whereby malignant plasma cells accumulate in the bone marrow (BM). These metabolic changes consist of generation, inhibition and accumulation of metabolites and metabolic shifts in MM cells. Changes in the BM micro-environment could be the reason for such adjustments. Enhancement of glycolysis and glutaminolysis is found in MM cells compared to healthy cells...
April 14, 2018: International Journal of Molecular Sciences
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