keyword
MENU ▼
Read by QxMD icon Read
search

Nicotine abuse

keyword
https://www.readbyqxmd.com/read/28074940/alpha7-nicotinic-acetylcholine-receptor-is-required-for-amyloid-pathology-in-brain-endothelial-cells-induced-by-glycoprotein-120-methamphetamine-and-nicotine
#1
Liqun Liu, Jingyi Yu, Li Li, Bao Zhang, Lingjuan Liu, Chun-Hua Wu, Ambrose Jong, Ding-An Mao, Sheng-He Huang
One of the most challenging issues in HIV-associated neurocognitive disorders (HAND) caused by HIV-1 virotoxins and drug abuse is the lack of understanding the underlying mechanisms that are commonly associated with disorders of the blood-brain barrier (BBB), which mainly consists of brain microvascular endothelial cells (BMEC). Here, we hypothesized that Glycoprotein 120 (gp120), methamphetamine (METH) and nicotine (NT) can enhance amyloid-beta (Aβ) accumulation in BMEC through Alpha7 nicotinic acetylcholine receptor (α7 nAChR)...
January 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28058022/role-of-original-and-modified-frey-s-procedures-in-chronic-pancreatitis
#2
Chun-Lu Tan, Hao Zhang, Min Yang, Shao-Jun Li, Xu-Bao Liu, Ke-Zhou Li
AIM: To retrospectively review patients with chronic pancreatitis (CP) treated with Frey's procedures between January 2009 and January 2014. METHODS: A retrospective review was performed of patients with CP treated with Frey's procedures between January 2009 and January 2014 in the Department of Pancreatic Surgery. A cross-sectional study of postoperative pain relief, quality of life (QoL), and alcohol and nicotine abuse was performed by clinical interview, letters and telephone interview in January 2016...
December 21, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28038309/diazepam-inhibits-electrically-evoked-and-tonic-dopamine-release-in-the-nucleus-accumbens-and-reverses-the-effect-of-amphetamine
#3
Alexander Gomez-A, Amanda Maino Fiorenza, Suelen Lucio Boschen, Adam H Sugi, Danielle Beckman, Sergio T Ferreira, Kendall H Lee, Charles D Blaha, Claudio Da Cunha
Diazepam is a benzodiazepine receptor agonist with anxiolytic and addictive properties. Although most drugs of abuse increase dopamine release in the nucleus accumbens, here we show that not only it causes the opposite effect but also prevents amphetamine action on increasing dopamine release. We used 20 min sampling in vivo microdialysis and subsecond fast-scan cyclic voltammetry recordings at carbon-fiber microelectrodes to show that diazepam caused a dose-dependent decrease in tonic and electrically-evoked dopamine release in the nucleus accumbens of urethane anesthetized adult male Swiss mice...
December 30, 2016: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28029335/enhanced-susceptibility-of-ca3-hippocampus-to-prenatal-nicotine-exposure
#4
O O Kalejaiye, M C Gondré-Lewis
The brain is highly susceptible to adverse effects of drugs of abuse during early phases of life. Prenatal nicotine exposure (PNE), a preventable cause of gestational and infant mortality, can alter neuron wiring and induce sustained deficits in attention and learning. Here, a rat model of PNE (embryonic days 7-21) was used to examine the maturing hippocampus, which encodes new memories and processes emotional memory. Components of synaptic signaling were evaluated at postnatal day 14 (P14), a period of prolific synaptogenesis in rats, to determine if glutamatergic transmission-associated molecules are regulated in subregions of hippocampus as early as P14...
December 28, 2016: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/28012948/orbitofrontal-participation-in-sign-and-goal-tracking-conditioned-responses-effects-of-nicotine
#5
Sierra J Stringfield, Matthew I Palmatier, Charlotte A Boettiger, Donita L Robinson
Pavlovian conditioned stimuli can acquire incentive motivational properties, and this phenomenon can be measured in animals using Pavlovian conditioned approach behavior. Drugs of abuse can influence the expression of this behavior, and nicotine in particular exhibits incentive amplifying effects. Both conditioned approach behavior and drug abuse rely on overlapping corticolimbic circuitry. We hypothesize that the orbitofrontal cortex (OFC) regulates conditioned approach, and that one site of nicotine action is in the OFC where it reduces cortical output...
December 22, 2016: Neuropharmacology
https://www.readbyqxmd.com/read/27994114/nicotine-and-tobacco-as-substances-of-abuse-in-children-and-adolescents
#6
Lorena M Siqueira
Nicotine is the primary pharmacologic component of tobacco, and users of tobacco products seek out its effects. The highly addictive nature of nicotine is responsible for its widespread use and difficulty with quitting. This technical report focuses on nicotine and discusses the stages of use in progression to dependence on nicotine-containing products; the physiologic characteristics, neurobiology, metabolism, pharmacogenetics, and health effects of nicotine; and acute nicotine toxicity. Finally, some newer approaches to cessation are noted...
January 2017: Pediatrics
https://www.readbyqxmd.com/read/27931777/effects-of-maternal-separation-on-nicotine-induced-conditioned-place-preference-and-subsequent-learning-and-memory-in-adolescent-female-rats
#7
Fatemeh Dalaveri, Nouzar Nakhaee, Khadijeh Esmaeilpour, Saeed Esmaeili Mahani, Vahid Sheibani
Adverse early life experiences can potentially increase risk for drug abuse later in life. However, little research has been conducted studying the effects of maternal separation (MS), an experimental model for early life stress, on the rewarding effects of nicotine. Cognitive function may be affected by MS. So, we also investigated whether nicotine administration affect spatial learning and memory in MS adolescent female rats. Rat pups were subjected to daily MS for 15min (MS15) or 180min (MS180) during the first 2 weeks of life or reared under normal animal facility rearing (AFR) conditions...
December 5, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27929684/acute-effects-of-snus-in-never-tobacco-users-a-pilot-study
#8
Jenny E Ozga, Nicholas J Felicione, Daniel Elswick, Melissa D Blank
BACKGROUND: Snus tobacco characteristics may attract non-tobacco users, including relatively low, but pharmacologically active, doses of nicotine. Lower nicotine doses may limit adverse drug effects while also producing a physiologically active response. OBJECTIVES: This pilot study is the first to profile the acute effects of snus on physiological and subjective assessments in a sample of never-tobacco users. METHODS: Eleven never-tobacco users (five women; <100 uses/lifetime) were recruited from the community via university-approved advertisements...
December 8, 2016: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/27929656/epilogue-to-special-issue-on-tobacco-and-other-substance-use-disorders-links-and-implications
#9
Steven A Schroeder
This paper summarizes The American Journal of Drug and Alcohol Abuse special issue and offers suggestions for future steps. People who use alcohol or other addictive substances are much more likely to use tobacco. Yet, clinicians and scientists have long regarded these addiction categories as separate and unrelated. The resultant benign neglect of tobacco use has had disastrous consequences on patients. This special issue is an important step toward remedying that situation. It has reviewed what is known and what more needs to be discovered regarding the co-occurrence of tobacco use disorder (TUD) and other substance use disorders (SUDs)...
December 8, 2016: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/27921634/smoking-cessation-in-smoke-free-prisons-a-grounded-theory-study
#10
Ashleigh Djachenko, Winsome St John, Creina Mitchell
Purpose Prisoners are vulnerable to tobacco addiction and have a smoking prevalence significantly higher than that of the general community. The context of this study was the implementation of a "smoke-free prisons" policy, which imposed forced smoking cessation onto the Queensland, Australian prison population. The study asked the question: "What are the psychosocial processes in which male prisoners engage during smoking cessation in a smoke-free environment?" Design/methodology/approach Qualitative interviews were conducted with 15 prisoners in South-east Queensland smoke-free correctional centres...
December 19, 2016: International Journal of Prisoner Health
https://www.readbyqxmd.com/read/27909988/predicting-the-abuse-liability-of-entactogen-class-new-and-emerging-psychoactive-substances-via-preclinical-models-of-drug-self-administration
#11
Shawn M Aarde, Michael A Taffe
Animal models of drug self-administration are currently the gold standard for making predictions regarding the relative likelihood that a recreational drug substance will lead to continued use and addiction. Such models have been found to have high predictive accuracy and discriminative validity for a number of drug classes including ethanol, nicotine, opioids, and psychostimulants such as cocaine and methamphetamine. Members of the entactogen class of psychostimulants (drugs that produce an "open mind state" including feelings of interpersonal closeness, intimacy and empathy) have been less frequently studied in self-administration models...
December 2, 2016: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/27905916/study-protocol-a-dose-escalating-phase-2-study-of-oral-lisdexamfetamine-in-adults-with-methamphetamine-dependence
#12
Nadine Ezard, Adrian Dunlop, Brendan Clifford, Raimondo Bruno, Andrew Carr, Alexandra Bissaker, Nicholas Lintzeris
BACKGROUND: The treatment of methamphetamine dependence is a continuing global health problem. Agonist type pharmacotherapies have been used successfully to treat opioid and nicotine dependence and are being studied for the treatment of methamphetamine dependence. One potential candidate is lisdexamfetamine, a pro-drug for dexamphetamine, which has a longer lasting therapeutic action with a lowered abuse potential. The purpose of this study is to determine the safety of lisdexamfetamine in this population at doses higher than those currently approved for attention deficit hyperactivity disorder or binge eating disorder...
December 1, 2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27870459/sex-differences-in-nicotine-preference
#13
REVIEW
Sakire Pogun, Gorkem Yararbas, Tanseli Nesil, Lutfiye Kanit
Smoking is the major cause of preventable deaths worldwide, and although there is a decline in overall smoking prevalence in developed countries, the decline in women is less pronounced than in men. Women become dependent faster and experience greater difficulties in quitting. Similar trends have been observed in animal models of nicotine/tobacco addiction. Individual differences in vulnerability to drug abuse are also observed in nicotine/tobacco addiction and point to the importance of sex differences. This Review, summarizes findings from three experimental approaches used to depict nicotine preference in animal models, intravenous and oral nicotine self-administration and nicotine-induced conditioned place preference...
January 2, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27866932/oxytocin-attenuates-aversive-response-to-nicotine-and-anxiety-like-behavior-in-adolescent-rats
#14
Hyunchan Lee, Minji Jang, Jihyun Noh
Initial tobacco use is initiated with rewarding and aversive properties of nicotine and aversive response to nicotine plays a critical role in nicotine dependency. Decrease of nicotine aversion increases the nicotine use that causes behavioral and neuronal changes of animals. Oxytocin influences drug abuse and reciprocally affect vulnerability to drug use. To assess the effect of oxytocin on initial nicotine aversion and anxiety, we examined voluntary oral nicotine intake and anxiety-like behavior following oxytocin treatment in adolescent rats...
November 17, 2016: Neuroscience Research
https://www.readbyqxmd.com/read/27848935/distinct-roles-of-creb-within-the-ventral-and-dorsal-hippocampus-in-mediating-nicotine-withdrawal-phenotypes
#15
Miranda L Fisher, Rachel M LeMalefant, Luyi Zhou, Gavin Huang, Jill R Turner
Addiction to nicotine and the inability to quit smoking are influenced by genetic factors, emphasizing the importance of understanding how genes and drugs of abuse mechanistically impact each other. One well-characterized protein responsible for regulating both response to drugs and gene expression is the transcription factor CREB (cAMP-responsive element binding protein). Previous work indicates that hippocampal-specific alterations in CREB signaling and synaptic plasticity may underlie certain nicotine withdrawal phenotypes...
December 14, 2016: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27848217/pregabalin-for-the-treatment-of-drug-and-alcohol-withdrawal-symptoms-a-comprehensive-review
#16
REVIEW
Rainer Freynhagen, Miroslav Backonja, Stephan Schug, Gavin Lyndon, Bruce Parsons, Stephen Watt, Regina Behar
Treatments for physical dependence and associated withdrawal symptoms following the abrupt discontinuation of prescription drugs (such as opioids and benzodiazepines), nicotine, alcohol, and cannabinoids are available, but there is still a need for new and more effective therapies. This review examines evidence supporting the potential use of pregabalin, an α2δ voltage-gated calcium channel subunit ligand, for the treatment of physical dependence and associated withdrawal symptoms. A literature search of the MEDLINE and Cochrane Library databases up to and including 11 December 2015 was conducted...
December 2016: CNS Drugs
https://www.readbyqxmd.com/read/27817750/l-tetrahydropalmatine-reduces-nicotine-self-administration-and-reinstatement-in-rats
#17
Shamia L Faison, Charles W Schindler, Steven R Goldberg, Jia Bei Wang
BACKGROUND: The negative consequences of nicotine use are well known and documented, however, abstaining from nicotine use and achieving abstinence poses a major challenge for the majority of nicotine users trying to quit. l-Tetrahydropalmatine (l-THP), a compound extracted from the Chinese herb Corydalis, displayed utility in the treatment of cocaine and heroin addiction via reduction of drug-intake and relapse. The present study examined the effects of l-THP on abuse-related effects of nicotine...
November 7, 2016: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/27793544/modulation-of-ethanol-reward-sensitivity-by-nicotinic-acetylcholine-receptors-containing-the-%C3%AE-6-subunit
#18
Melissa J Guildford, Anthony V Sacino, Andrew R Tapper
The prevalent co-abuse of nicotine and alcohol suggests a common neural mechanism underlying the actions of the two drugs. Nicotine, the addictive component of tobacco, activates nicotinic acetylcholine receptors (nAChRs) containing the α6 subunit (α6* nAChRs) in dopaminergic (DAergic) neurons of the ventral tegmental area (VTA), a region known to be crucial for drug reward. Recent evidence suggests that ethanol may potentiate ACh activation of these receptors as well, although whether α6* nAChR expression is necessary for behavioral effects of acute ethanol exposure is unknown...
December 2016: Alcohol
https://www.readbyqxmd.com/read/27781096/abortion-substance-abuse-and-mental-health-in-early-adulthood-thirteen-year-longitudinal-evidence-from-the-united-states
#19
Donald Paul Sullins
OBJECTIVE: To examine the links between pregnancy outcomes (birth, abortion, or involuntary pregnancy loss) and mental health outcomes for US women during the transition into adulthood to determine the extent of increased risk, if any, associated with exposure to induced abortion. METHOD: Panel data on pregnancy history and mental health history for a nationally representative cohort of 8005 women at (average) ages 15, 22, and 28 years from the National Longitudinal Study of Adolescent to Adult Health were examined for risk of depression, anxiety, suicidal ideation, alcohol abuse, drug abuse, cannabis abuse, and nicotine dependence by pregnancy outcome (birth, abortion, and involuntary pregnancy loss)...
2016: SAGE Open Medicine
https://www.readbyqxmd.com/read/27780491/association-of-adverse-childhood-experiences-with-lifetime-mental-and-substance-use-disorders-among-men-and-women-aged-50-years
#20
Namkee G Choi, Diana M DiNitto, C Nathan Marti, Bryan Y Choi
BACKGROUND: Given growing numbers of older adults with mental and substance use disorders (MSUDs), this study examined the association between ten types of adverse childhood experiences (ACEs) and lifetime MSUDs among those aged 50+. METHODS: Data (N = 14,738 for the 50+ age group) came from the 2012 to 2013 National Epidemiologic Survey on Alcohol and Related Conditions. Using multivariable binary logistic regression analyses, we examined relationships between ten ACEs and six lifetime MSUDs (major depressive disorder (MDD) and anxiety, post-traumatic stress, alcohol use, drug use, and nicotine use disorders)...
October 26, 2016: International Psychogeriatrics
keyword
keyword
53875
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"