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https://www.readbyqxmd.com/read/27890748/small-unruptured-intracranial-aneurysm-%C3%A2-5mm-associated-with-epilepsy-report-of-2-cases-and-literature-review
#1
Fuxin Lin, Hui Wan, Dezhi Kang, Yuanxiang Lin
BACKGROUND: Due to the continuing improvements in imaging technology, an increasing number of epileptogenic small (≤5mm) unruptured intracranial aneurysms (sUIA) are being diagnosed since 2000. However, they are not systematically described and reviewed until now. CASE DESCRIPTION AND THE LITERATURE REVIEW: We reported 2 patients with sUIA who initially presented with complex partial seizures (CPS). Scalp electroencephalography (EEG) showed the seizures activity arising from the mesial temporal/frontal areas, but conventional magnetic resonance imaging (MRI) scans were normal in both patients...
November 24, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27866088/is-ketogenic-diet-treatment-hepatotoxic-for-children-with-intractable-epilepsy
#2
Nur Arslan, Orkide Guzel, Engin Kose, Unsal Yılmaz, Pınar Kuyum, Betül Aksoy, Tansel Çalık
PURPOSE: Long-term ketogenic diet (KD) treatment has been shown to induce liver steatosis and gallstone formation in some in vivo and clinical studies. The aim of this retrospective study was to evaluate the hepatic side effects of KD in epileptic children. METHOD: A total of 141 patients (mean age: 7.1±4.1years [2-18 years], 45.4% girls), receiving KD at least one year for intractable epilepsy due to different diagnoses (congenital brain defects, GLUT-1 deficiency, West syndrome, tuberous sclerosis, hypoxic brain injury, etc...
November 13, 2016: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/27863250/histone-acetylome-wide-association-study-of-autism-spectrum-disorder
#3
Wenjie Sun, Jeremie Poschmann, Ricardo Cruz-Herrera Del Rosario, Neelroop N Parikshak, Hajira Shreen Hajan, Vibhor Kumar, Ramalakshmi Ramasamy, T Grant Belgard, Bavani Elanggovan, Chloe Chung Yi Wong, Jonathan Mill, Daniel H Geschwind, Shyam Prabhakar
The association of histone modification changes with autism spectrum disorder (ASD) has not been systematically examined. We conducted a histone acetylome-wide association study (HAWAS) by performing H3K27ac chromatin immunoprecipitation sequencing (ChIP-seq) on 257 postmortem samples from ASD and matched control brains. Despite etiological heterogeneity, ≥68% of syndromic and idiopathic ASD cases shared a common acetylome signature at >5,000 cis-regulatory elements in prefrontal and temporal cortex. Similarly, multiple genes associated with rare genetic mutations in ASD showed common "epimutations...
November 17, 2016: Cell
https://www.readbyqxmd.com/read/27830114/disruptions-in-cortico-subcortical-covariance-networks-associated-with-anxiety-in-new-onset-childhood-epilepsy
#4
Camille Garcia-Ramos, Jack J Lin, Leonardo Bonilha, Jana E Jones, Daren C Jackson, Vivek Prabhakaran, Bruce P Hermann
Anxiety disorders represent a prevalent psychiatric comorbidity in both adults and children with epilepsy for which the etiology remains controversial. Neurobiological contributions have been suggested, but only limited evidence suggests abnormal brain volumes particularly in children with epilepsy and anxiety. Since the brain develops in an organized fashion, covariance analyses between different brain regions can be investigated as a network and analyzed using graph theory methods. We examined 46 healthy children (HC) and youth with recent onset idiopathic epilepsies with (n = 24) and without (n = 62) anxiety disorders...
2016: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27829458/retrospective-epidemiological-study-of-canine-epilepsy-in-japan-using-the-international-veterinary-epilepsy-task-force-classification-2015-2003-2013-etiological-distribution-risk-factors-survival-time-and-lifespan
#5
Yuji Hamamoto, Daisuke Hasegawa, Shunta Mizoguchi, Yoshihiko Yu, Masae Wada, Takayuki Kuwabara, Aki Fujiwara-Igarashi, Michio Fujita
BACKGROUND: Epilepsy is the most common neurological disease in veterinary practice. However, contrary to human medicine, epilepsy classification in veterinary medicine had not been clearly defined until recently. A number of reports on canine epilepsy have been published, reflecting in part updated proposals from the human epilepsy organization, the International League Against Epilepsy. In 2015, the International Veterinary Epilepsy Task Force (IVETF) published a consensus report on the classification and definition of canine epilepsy...
November 9, 2016: BMC Veterinary Research
https://www.readbyqxmd.com/read/27819402/-a-descriptive-study-of-non-symptomatic-epilepsy-according-to-age-at-onset-at-a-neuropediatric-section-of-regional-reference
#6
L Ochoa-Gomez, J Lopez-Pison, R Fernando-Martinez, C Fuertes-Rodrigo, P Samper-Villagrasa, L Monge-Galindo, J L Pena-Segura
AIM: A descriptive study of non-symptomatic epilepsy (idiopathic and cryptogenic), according to age at onset, monitored at a Neuropediatric Section of regional reference over a period of three years. PATIENTS AND METHODS: A review of neuropediatric database medical records of children with non-symptomatic epilepsy supervised from Jan 1, 2008 till December 31, 2010. RESULTS: Of the 4595 children attended during the period, 605 were diagnosed with epilepsy (13...
November 16, 2016: Revista de Neurologia
https://www.readbyqxmd.com/read/27787513/the-cyclic-vomiting-syndrome-threshold-a-framework-for-understanding-pathogenesis-and-predicting-successful-treatments
#7
David J Levinthal
Cyclic vomiting syndrome (CVS) is an uncommon, idiopathic disorder defined by recurrent, sudden-onset attacks of repetitive retching and vomiting that are separated by symptom-free intervals. CVS was long regarded as a disorder primarily experienced by children but is now known to present de novo in adulthood. Adult CVS has garnered more research attention over the past 20 years, and these efforts have identified some acute and prophylactic treatments for this disorder. However, CVS still lacks a unifying disease model, and this has hindered the development of new therapies...
October 27, 2016: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/27763968/effects-of-marijuana-on-ictal-and-interictal-eeg-activity-in-idiopathic-generalized-epilepsy
#8
Sanjeev Sivakumar, Deepti Zutshi, Navid Seraji-Bozorgzad, Aashit Shah
Marijuana-based treatment for refractory epilepsy shows promise in surveys, case series and clinical trials. However, literature on their electroencephalography (EEG) effects is sparse. Our objective is to analyze the effect of marijuana on EEG in a 24-year-old patient with idiopathic generalized epilepsy (IGE) treated with cannabis. We blindly reviewed three long-term EEGs-a 24-hour study while only on antiepileptic drugs (AEDs), a 72-hour EEG with Cannabis indica smoked on days one and three in addition to AEDs and a 48-hour EEG with combination C...
October 18, 2016: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
https://www.readbyqxmd.com/read/27753779/development-and-validation-of-an-hplc-uv-assay-for-the-therapeutic-monitoring-of-the-new-antiepileptic-drug-perampanel-in-human-plasma
#9
Valentina Franco, Roberto Marchiselli, Cinzia Fattore, Elena Tartara, Giovambattista De Sarro, Emilio Russo, Emilio Perucca
BACKGROUND: Perampanel, a new specific non-competitive α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor antagonist, has been recently approved in the United States and the European Union for the adjunctive treatment of focal seizures and primary generalized tonic-clonic seizures associated with idiopathic generalized epilepsy. A positive relationship between plasma perampanel concentration and improvement in seizure control has been identified in regulatory trials, suggesting that therapeutic drug monitoring could be useful in optimizing clinical response in patients with epilepsy treated with perampanel...
December 2016: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/27733824/structural-abnormalities-in-childhood-absence-epilepsy-voxel-based-analysis-using-diffusion-tensor-imaging
#10
Wenchao Qiu, Yuan Gao, Chuanyong Yu, Ailiang Miao, Lu Tang, Shuyang Huang, Zheng Hu, Jing Xiang, Xiaoshan Wang
Purpose: Childhood absence epilepsy (CAE) is a common syndrome of idiopathic generalized epilepsy. However, little is known about the brain structural changes in this type of epilepsy, especially in the default mode network (DMN) regions. This study aims at using the diffusion tensor imaging (DTI) technique to quantify structural abnormalities of DMN nodes in CAE patients. Method: DTI data were acquired in 14 CAE patients (aged 8.64 ± 2.59 years, seven females and seven males) and 16 age- and sex-matched healthy controls...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27726245/dynamic-functional-network-connectivity-in-idiopathic-generalized-epilepsy-with-generalized-tonic-clonic-seizure
#11
Feng Liu, Yifeng Wang, Meiling Li, Wenqin Wang, Rong Li, Zhiqiang Zhang, Guangming Lu, Huafu Chen
Idiopathic generalized epilepsy (IGE) has been linked with disrupted intra-network connectivity of multiple resting-state networks (RSNs); however, whether impairment is present in inter-network interactions between RSNs, remains largely unclear. Here, 50 patients with IGE characterized by generalized tonic-clonic seizures (GTCS) and 50 demographically matched healthy controls underwent resting-state fMRI scans. A dynamic method was implemented to investigate functional network connectivity (FNC) in patients with IGE-GTCS...
October 11, 2016: Human Brain Mapping
https://www.readbyqxmd.com/read/27662337/occipito-frontal-sharp-waves-an-under-recognized-eeg-pattern-in-self-limited-idiopathic-childhood-focal-epilepsy
#12
Elaine Wyllie, Ahsan Nv Moosa
We report four children who highlight the potentially under-recognized EEG pattern of bilaterally synchronous occipito-frontal sharp waves, which may occur in children with Panayiotopoulos-type self-limited childhood epilepsy but may be easily confused with the patterns of symptomatic generalized epilepsy. Our patients were young, healthy children who had infrequent, predominantly nocturnal, fairly prolonged seizures characterized by altered consciousness, vomiting, and autonomic features, or in one case nocturnal secondary generalized tonic clonic convulsion...
September 16, 2016: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
https://www.readbyqxmd.com/read/27646715/long-term-outcome-of-medically-treated-epilepsy
#13
M Sillanpää, D Schmidt
PURPOSE: To review the long-term outcome of epilepsy in population-based studies. METHOD: Analysis of population-based studies. RESULTS: About two of three patients with new-onset epilepsy will, in the long run, enter five-year terminal remission. Chances for remission are best for those with idiopathic or cryptogenic epilepsy. It is unclear whether the seizure outcome has improved over the last several decades. Social outcome, however, may have become better because of the improved level of knowledge on and public attitudes toward people with epilepsy, and possibly fewer prejudices at home, daycare, school, military and labor market...
September 9, 2016: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/27635114/are-theory-of-mind-skills-in-people-with-epilepsy-related-to-how-stigmatised-they-feel-an-exploratory-study
#14
A J Noble, A Robinson, A G Marson
Feelings of stigma are one of the main burdens reported by people with epilepsy (PWE). Adults with temporal or frontal lobe epilepsy and children with idiopathic generalised epilepsy are at risk of Theory of Mind (ToM) deficits. ToM refers to social cognitive skills, including the ability to understand the thoughts, intentions, beliefs, and emotions of others. It has been proffered that ToM deficits may contribute to the feelings of stigma experienced by PWE. In this study we tested this for the first time...
2016: Behavioural Neurology
https://www.readbyqxmd.com/read/27582661/are-idiopathic-generalized-epilepsies-focal
#15
Jerzy P Szaflarski
No abstract text is available yet for this article.
July 2016: Epilepsy Currents
https://www.readbyqxmd.com/read/27569067/technique-for-venipuncture-of-the-transverse-facial-vein-in-the-black-rhinoceros-diceros-bicornis
#16
Justin R Schlanser, George W Bohart, Deborah W Paperd, Cynthia Wagner, Mark Marquardt, Tara M Harrison
Through the use of operant conditioning, the authors developed a technique to facilitate obtaining blood samples from a black rhinoceros diagnosed with idiopathic epilepsy. The technique involved operant conditioning to facilitate venipuncture of the transverse facial vein, at an anatomic landmark on the lateral side of the face ventral to the medial canthus of the eye, and dorsal to the lateral commissure of the mouth. The investigators used standard operant conditioning protocols to train the animal for desensitization to a needle puncture in the facial vein...
November 2016: Zoo Biology
https://www.readbyqxmd.com/read/27568598/effectiveness-and-tolerability-of-perampanel-in-children-and-adolescents-with-refractory-epilepsies-an-italian-observational-multicenter-study
#17
P De Liso, F Vigevano, N Specchio, L De Palma, P Bonanni, E Osanni, G Coppola, P Parisi, S Grosso, A Verrotti, A Spalice, F Nicita, N Zamponi, S Siliquini, L Giordano, P Martelli, R Guerrini, A Rosati, L Ilvento, V Belcastro, P Striano, M S Vari, G Capovilla, F Beccaria, O Bruni, A Luchetti, G Gobbi, A Russo, D Pruna, A E Tozzi, R Cusmai
PURPOSE: To evaluate the efficacy and tolerability of Perampanel (PER) in children and adolescents with refractory epilepsies in daily clinical practice conditions. PATIENTS AND METHODS: This Italian multicenter retrospective observational study was performed in 16 paediatric epilepsy centres. Inclusion criteria were: (i) ≤18 years of age, (ii) history of refractory epilepsy, (iii) a follow-up ≥5 months of PER add-on therapy. Exclusion criteria were: (i) a diagnosis of primary idiopathic generalized epilepsy, (ii) variation of concomitant AEDs during the previous 4 weeks...
August 18, 2016: Epilepsy Research
https://www.readbyqxmd.com/read/27567267/moral-judgment-in-patients-with-idiopathic-generalized-epilepsy
#18
YuBao Jiang, YiMing Zhu, JiaoNan Wu, Nong Zhou, PanPan Hu, Kai Wang
PURPOSE: The aim of the current study was to investigate morality while also investigating frontal lobe function with the goal of studying the relationship between frontal lobe and morality in patients with idiopathic generalized epilepsy. METHOD: A total of 23 right-handed patients with IGE and 25 right-handed healthy participants agreed to participate. Participants made judgments on a series of 50 hypothetical scenarios, which were adapted from a previously published set...
October 2016: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/27521439/phenotypic-spectrum-of-gabra1-from-generalized-epilepsies-to-severe-epileptic-encephalopathies
#19
Katrine Johannesen, Carla Marini, Siona Pfeffer, Rikke S Møller, Thomas Dorn, Christina Niturad, Elena Gardella, Yvonne Weber, Marianne Søndergård, Helle Hjalgrim, Mariana Nikanorova, Felicitas Becker, Line H G Larsen, Hans A Dahl, Oliver Maier, Davide Mei, Saskia Biskup, Karl M Klein, Philipp S Reif, Felix Rosenow, Abdallah F Elias, Cindy Hudson, Katherine L Helbig, Susanne Schubert-Bast, Maria R Scordo, Dana Craiu, Tania Djémié, Dorota Hoffman-Zacharska, Hande Caglayan, Ingo Helbig, Jose Serratosa, Pasquale Striano, Peter De Jonghe, Sarah Weckhuysen, Arvid Suls, Kai Muru, Inga Talvik, Tiina Talvik, Hiltrud Muhle, Ingo Borggraefe, Imma Rost, Renzo Guerrini, Holger Lerche, Johannes R Lemke, Guido Rubboli, Snezana Maljevic
OBJECTIVE: To delineate phenotypic heterogeneity, we describe the clinical features of a cohort of patients with GABRA1 gene mutations. METHODS: Patients with GABRA1 mutations were ascertained through an international collaboration. Clinical, EEG, and genetic data were collected. Functional analysis of 4 selected mutations was performed using the Xenopus laevis oocyte expression system. RESULTS: The study included 16 novel probands and 3 additional family members with a disease-causing mutation in the GABRA1 gene...
September 13, 2016: Neurology
https://www.readbyqxmd.com/read/27504264/atypical-benign-partial-epilepsy-of-childhood-with-acquired-neurocognitive-lexical-semantic-and-autistic-spectrum-disorder
#20
Nicholas M Allen, Judith Conroy, Thierry Deonna, Dara McCreary, Paul McGettigan, Cathy Madigan, Imogen Carter, Sean Ennis, Sally A Lynch, Amre Shahwan, Mary D King
Atypical benign partial epilepsy (ABPE) of childhood or pseudo-Lennox syndrome is a form of idiopathic focal epilepsy characterized by multiple seizure types, focal and/or generalized epileptiform discharges, continuous spike-wave during sleep (CSWS), and sometimes reversible neurocognitive deficits. There are few reported cases of ABPE describing detailed correlative longitudinal follow-up of the various associated neurocognitive, language, social communicative, or motor deficits, in parallel with the epilepsy...
2016: Epilepsy & Behavior Case Reports
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