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https://www.readbyqxmd.com/read/29679871/groundwater-chemistry-and-human-health-risk-assessment-in-the-mining-region-of-east-singhbhum-jharkhand-india
#1
Umesh Kumar Singh, A L Ramanathan, V Subramanian
Groundwater chemistry of mining region of East Singhbhum district having complex contaminant sources were investigated based on heavy metals loads and other hydrochemical constituents. This study aimed to identify the degree of heavy metals exposure and their potential health risk to local population. The results of hydrochemical analysis showed that Na+ , K+ , and Ca2+ ions are the dominant cations in the groundwater, while HCO3 - , F- and Cl- ions dominate the anionic part of the groundwater. The weathering process was considered the dominant factor to determine the major ionic composition in the study area...
April 13, 2018: Chemosphere
https://www.readbyqxmd.com/read/29671966/perceptions-of-organizational-capacity-to-promote-physical-activity-in-canada-and-participaction-s-influence-five-years-after-its-relaunch-a-qualitative-study
#2
Subha Ramanathan, Guy Faulkner, Tanya Berry, Sameer Deshpande, Amy E Latimer-Cheung, Ryan E Rhodes, John C Spence, Mark S Tremblay
INTRODUCTION: ParticipACTION is a Canadian physical activity communications and social marketing organization relaunched in 2007. The purpose of this study was to qualitatively investigate organizational capacity for physical activity promotion among Canadian organizations, and the influence of ParticipACTION on capacity five years after relaunch. METHODS: Using a purposive sampling strategy, semi-structured telephone interviews were conducted with 44 key informants representing national, provincial, and local organizations with a mandate to promote physical activity...
April 2018: Health Promotion and Chronic Disease Prevention in Canada
https://www.readbyqxmd.com/read/29671965/participaction-after-5-years-of-relaunch-a-quantitative-survey-of-canadian-organizational-awareness-and-capacity-regarding-physical-activity-initiatives
#3
Guy Faulkner, Subha Ramanathan, Ronald C Plotnikoff, Tanya Berry, Sameer Deshpande, Amy E Latimer-Cheung, Ryan E Rhodes, Mark S Tremblay, John C Spence
INTRODUCTION: ParticipACTION is a Canadian physical activity communications and social marketing organization relaunched in 2007. This study assesses the capacity of Canadian organizations to adopt, implement, and promote physical activity initiatives. The four objectives were to compare findings from baseline (2008) and follow-up (2013) with respect to: (1) awareness of ParticipACTION; (2) organizational capacity to adopt, implement and promote physical activity initiatives; (3) potential differences in capacity based on organizational size, sector, and mandate; and (4) assess perceptions of ParticipACTION five years after relaunch...
April 2018: Health Promotion and Chronic Disease Prevention in Canada
https://www.readbyqxmd.com/read/29671262/developing-mammalian-cellular-clock-models-using-firefly-luciferase-reporter
#4
Chidambaram Ramanathan, Andrew C Liu
In mammals, many aspects of metabolic, physiological, and behavioral processes are regulated by endogenous circadian clocks. Oscillators of different tissue types share a common molecular mechanism at the cellular and molecular level which underlies the rhythmic expression of genes. Individual cells are the functional units for rhythm generation and cell-based clock models offer experimental tractability for discovery. Cellular clock models can be developed by introducing a noninvasive and readily detectable luciferase bioluminescence reporter as a rhythmic output, in which the promoter of a rhythmically expressed gene is fused with the firefly luciferase (Luc) gene...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29667422/intestinal-permeability-of-mitragynine-in-rats-using-in-situ-absorption-model
#5
J D Yuvenesan Jagabalan, Vikneswaran Murugaiyah, Hadzliana Zainal, Sharif Mahsufi Mansor, Surash Ramanathan
The intestinal permeability of mitragynine was investigated in situ using a single pass intestinal perfusion (SPIP) absorption model, in small intestine of rat using mitragynine in the absence/presence of the permeability markers, P-gp and/or CYP3A4 inhibitors. Mitragynine demonstrated high intestinal permeability (Peff of 1.11 × 10-4  cm/s) that is in the range of highly permeable drugs such as propranolol (Peff of 1.27 × 10-4  cm/s) indicating that it readily crosses the intestine. The addition of azithromycin (P-glycoprotein inhibitor) and ciprofloxacin (CYP3A4 inhibitor) or combination of both has no effect on intestinal permeability of mitragynine across the rat small intestine...
April 18, 2018: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/29662494/evolution-of-neutralization-response-in-hiv-1-subtype-c-infected-individuals-exhibiting-broad-cross-clade-neutralization-of-hiv-1-strains
#6
Narayanaiah Cheedarla, Babu Hemalatha, Brahmaiah Anangi, Kannan Muthuramalingam, Murugesan Selvachithiram, Pattabiraman Sathyamurthi, Nandagopal Kailasam, Raghavan Varadarajan, Soumya Swaminathan, Srikanth Prasad Tripathy, S Kalyanaraman Vaniambadi, D Ramanathan Vadakkupattu, Luke Elizabeth Hanna
Strain-specific neutralizing antibodies develop in all human immunodeficiency virus type 1 (HIV-1)-infected individuals. However, only 10-30% of infected individuals produce broadly neutralizing antibodies (bNAbs). Identification and characterization of these bNAbs and understanding their evolution dynamics are critical for obtaining useful clues for the development of an effective HIV vaccine. Very recently, we published a study in which we identified 12 HIV-1 subtype C-infected individuals from India whose plasma showed potent and broad cross-clade neutralization (BCN) ability (1)...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29657372/targeted-interventions-in-critically-ill-children-with-severe-dengue
#7
Suchitra Ranjit, Gokul Ramanathan, Balasubramaniam Ramakrishnan, Niranjan Kissoon
Background: The World Health Organization guidelines provide suggestions on early recognition and treatment of severe dengue (SD); however, mortality in this group can be high and is related both to disease severity and the treatment complications. Subjects and Methods: In this prospective observational study, we report our results where standard therapy (ST) was enhanced by Intensive Care Unit (ICU) supportive measures that have proven beneficial in other conditions that share similar pathophysiology of capillary leak and fluid overload...
March 2018: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29657221/unusual-cause-of-crystalline-nephropathy
#8
Natarajan Gopalakrishnan, Dhanasekaran Rajasekar, Jeyachandran Dhanapriya, Thanigachalam Dineshkumar, Ramanathan Sakthirajan, T Balasubramaniyan, V Murugesan
Adenine phosphoribosyltransferase deficiency is a rare, inherited autosomal recessive disease presenting with 2,8-dihydroxyadenine (DHA) urolithiasis, DHA nephropathy, and chronic kidney disease. The presence of DHA crystals in urine and renal biopsy is pathognomonic of the disease. We report a 23-year-old female with acute renal failure and nephrotic proteinuria. Urinalysis showed reddish brown, round crystals with dark outline, and central spicules consistent with 2,8-DHA crystals. Renal biopsy showed membranous nephropathy and 2,8-DHA nephropathy...
March 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29657219/paraneoplastic-glomerulopathies-associated-with-hematologic-malignancies
#9
Jeyachandran Dhanapriya, Thanigachalam Dineshkumar, Ramanathan Sakthirajan, Dhanikachalam Surendar, Natarajan Gopalakrishnan, T Balasubramaniyan
Paraneoplastic glomerulopathy (PG) includes a group of glomerular lesions that are not directly related to tumor burden, invasion, or metastasis, but induced by products from tumor cells such as hormones, growth factors, cytokines, and tumor antigens. PG was first described by Galloway in 1922, in which nephrotic syndrome (NS) secondary to Hodgkin's lymphoma was reported. They can present before, at the time of diagnosis, during remission, or at relapse of the hematological malignancies. We present three cases of paraneoplastic NS associated with hematological malignancies...
March 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29649950/scrotal-skin-nodule-sebaceous-cyst-or-tuberculosis-a-lesson-learnt
#10
Jojo Joseph, Abhinav Menon, Rudra Ramanathan, Deeksha Misra, Gabriel Rodrigues
Tuberculosis (TB) is a great mimic of many diseases and may present a dilemma in diagnosis. Sebaceous cyst is the commonest swelling that occurs in the scrotal skin. We present a 23-year-old patient who presented with a painful hard scrotal skin nodule, clinically diagnosed to be an infected calcified sebaceous cyst, excised and reported to be due to TB. Nodular scrotal skin TB is extremely rare but should nonetheless be considered as a differential diagnosis in regions where it is prevalent. Thus, excision of any suspicious nodule is indicated...
January 1, 2018: Tropical Doctor
https://www.readbyqxmd.com/read/29649469/phosphatidylserine-is-not-just-a-cleanup-crew-but-also-a-well-meaning-teacher
#11
Fiona Y Glassman, Jennifer L Schneider, Radha Ramakrishnan, Robert K Dingman, Murali Ramanathan, Richard B Bankert, Sathy V Balu-Iyer
Phosphatidylserine (PS) exposure during apoptosis leads to silent clearance of cells without adverse immune reactions to self-proteins. Given the biological functions of PS in cellular cleanup and global immunosuppression, we hypothesized that administration of PS-protein complexes would reduce immunogenicity. Here, we report that exposing Pompe disease mice to acid alpha glucosidase (rhGAA) with PS or immunosuppressant dexamethasone (Dex) resulted in lower anti-rhGAA-antibodies than in animals receiving rhGAA alone...
April 9, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29642516/erratum-ramanathan-a-et-al-metal-incorporated-mesoporous-silicates-tunable-catalytic-properties-and-applications-molecules-2018-23-263
#12
Anand Ramanathan, Bala Subramaniam
The authors wish to make the following change to their paper [1].[...].
April 9, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29628835/analysis-of-functioning-and-efficiency-of-a-code-blue-system-in-a-tertiary-care-hospital
#13
Srinivas Monangi, Rangraj Setlur, Ramprasad Ramanathan, Sidharth Bhasin, Mridul Dhar
Background: "Code blue" (CB) is a popular hospital emergency code, which is used by hospitals to alert their emergency response team of any cardiorespiratory arrest. The factors affecting the outcomes of emergencies are related to both the patient and the nature of the event. The primary objective was to analyze the survival rate and factors associated with survival and also practical problems related to functioning of a CB system (CBS). Materials and Methods: After the approval of hospital ethics committee, an analysis and audit was conducted of all patients on whom a CB had been called in our tertiary care hospital over 24 months...
April 2018: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/29618884/simultaneous-occurrence-of-a-midline-sublingual-dermoid-cyst-with-respiratory-epithelium-and-submental-dermoid-cyst-in-a-paediatric-patient-a-case-report-and-review-of-literature
#14
Manikandhan Ramanathan, Sivapathasundharam Balasundharam, Amelia Christabel, Preethi Murali, Sneha Pandem
Aim: To present the case of a simultaneously occuring sublingual dermoid cyst with respiratory epthelium and a submental dermoid cyst, and also to review literatures on the same. Methods: A complete examination, radiograph, MRI and excision biopsy of both lesions were carried out and diagnosis was arrived at histopathologically. Results: The histopathology of the submental swelling revealed orthokeratinized stratified squamous epithelium with underlying connective tissue consisting of dense irregularly arranged collagen fibres with fibroblasts along with chronic inflammatory cell infiltrate of lymphocytes and plasma cells...
June 2018: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/29617037/final-impression-techniques-and-materials-for-making-complete-and-removable-partial-dentures
#15
REVIEW
Srinivasan Jayaraman, Balendra P Singh, Balasubramanian Ramanathan, Murukan Pazhaniappan Pillai, Laura MacDonald, Richard Kirubakaran
BACKGROUND: Endentulism is relatively common and is often treated with the provision of complete or partial removable dentures. Clinicians make final impressions of complete dentures (CD) and removable partial dentures (RPD) using different techniques and materials. Applying the correct impression technique and material, based on an individual's oral condition, improves the quality of the prosthesis, which may improve quality of life. OBJECTIVES: To assess the effects of different final-impression techniques and materials used to make complete dentures, for retention, stability, comfort, and quality of life in completely edentulous people...
April 4, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29602765/left-atrium-and-cardiovascular-risk-does-functionality-matter-more-than-size
#16
EDITORIAL
Ramanathan Parameswaran, Jonathan M Kalman
No abstract text is available yet for this article.
March 30, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29601923/evaluation-and-management-of-testosterone-deficiency-aua-guideline
#17
John P Mulhall, Landon W Trost, Robert E Brannigan, Emily G Kurtz, J Bruce Redmon, Kelly A Chiles, Deborah J Lightner, Martin M Miner, M Hassan Murad, Christian J Nelson, Elizabeth A Platz, Lakshmi V Ramanathan, Ronald W Lewis
PURPOSE: There has been a marked increase in testosterone prescriptions in the past decade resulting in a growing need to give practicing clinicians proper guidance on the evaluation and management of the testosterone deficient patient. MATERIALS & METHODS: A systematic review utilized research from the Mayo Clinic Evidence Based Practice Center and additional supplementation by the authors. Evidence-based statements were based on body of evidence strength Grade A, B, or C and were designated as Strong, Moderate, and Conditional Recommendations with additional statements presented in the form of Clinical Principles or Expert Opinions...
March 27, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29587973/improved-utilization-of-operating-room-time-for-trainee-cataract-surgery-in-a-public-hospital-setting
#18
J Minjy Kang, Sriranjani P Padmanabhan, Julie Schallhorn, Neeti Parikh, Saras Ramanathan
PURPOSE: To examine the effect of group goal and group performance theories on operating room efficiency in resident-performed cataract surgery. SETTING: Zuckerberg San Francisco General Hospital and Trauma Center, Department of Ophthalmology, University of California, San Francisco, California, USA. DESIGN: Prospective case series. METHODS: This study assessed 4 specific segments of operating room utilization identified as room-to-incision time, incision-to-close time, close-to-exit time, and room turnover time...
February 2018: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29587186/role-of-%C3%AE-2-3-specific-gaba-a-receptor-isoforms-in-the-development-of-hippocampus-kindling-epileptogenesis
#19
Doodipala Samba Reddy, Ryan F Yoshimura, Gunasekaran Ramanathan, Chase Carver, Timothy B Johnstone, Derk J Hogenkamp, Kelvin W Gee
OBJECTIVE: Subunit-specific positive allosteric modulators (PAMs) of gamma-aminobutyric acid-A (GABA-A) receptors are commonly used to uncover the role of GABA-A receptor isoforms in brain function. Recently, we have designed novel PAMs selective for β2/3 -subunit containing GABA-A receptors (β2/3 -selective PAMs) that are nonbenzodiazepine site-mediated and do not show an α-subunit isoform selectivity, yet exhibit anxiolytic efficacy with reduced potential for sedation, cognitive impairment, and tolerance...
March 24, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29578382/pre-operative-screening-for-asymptomatic-bacteriuria-and-associations-with-post-operative-outcomes-in-patients-with-spinal-cord-injury
#20
Margaret A Fitzpatrick, Katie J Suda, Stephen P Burns, Linda Poggensee, Swetha Ramanathan, Charlesnika T Evans
CONTEXT: Screening for asymptomatic bacteriuria (ASB) before non-urologic surgery is common but of unclear benefit. Our aim was to describe pre-operative ASB screening and post-operative outcomes in patients with neurogenic bladder due to spinal cord injury (SCI). METHODS: This was a descriptive retrospective cohort study of adults with SCI undergoing neurosurgical spine or orthopedic lower limb surgery from 10/1/2012-9/30/2014 at Veterans Affairs (VA) medical centers...
March 26, 2018: Journal of Spinal Cord Medicine
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