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https://www.readbyqxmd.com/read/28726132/phase-i-dose-escalation-study-of-nms-1286937-an-orally-available-polo-like-kinase-1-inhibitor-in-patients-with-advanced-or-metastatic-solid-tumors
#1
Glen J Weiss, Gayle Jameson, Daniel D Von Hoff, Barbara Valsasina, Cristina Davite, Claudia Di Giulio, Francesco Fiorentini, Rachele Alzani, Patrizia Carpinelli, Alessandro Di Sanzo, Arturo Galvani, Antonella Isacchi, Ramesh K Ramanathan
Background Pharmacological inhibition of polo-like kinase 1 (PLK1) represents a new approach for the treatment of solid tumors. This study was aimed at determining the first cycle dose-limiting toxicities (DLTs) and related maximum tolerated dose (MTD) of NMS-1286937, a selective ATP-competitive PLK1-specific inhibitor. Secondary objectives included evaluation of its safety and pharmacokinetic (PK) profile in plasma, its antitumor activity, and its ability to modulate intracellular targets in biopsied tissue...
July 20, 2017: Investigational New Drugs
https://www.readbyqxmd.com/read/28722409/conformational-landscape-of-tri-n-butyl-phosphate-matrix-isolation-infrared-spectroscopy-and-systematic-computational-analysis
#2
Nagarajan Ramanathan, Kalyanasundaram Sundararajan, Kodumudi S Viswanathan
The conformations of tri-n-butyl phosphate (TBP) were studied using matrix isolation infrared spectroscopy and DFT calculations. TBP was trapped in a N2 matrix using both effusive and supersonic sources and its infrared spectra were recorded. The computational exploration of TBP is a very demanding problem to confront, due to the presence of a large multitude of conformations in TBP. To simplify the problem, computations were done on model compounds, dimethyl butyl phosphate (DMBP) and dibutyl methyl phosphate (DBMP), to systematically arrive at the conformations of TBP that are expected to contribute to its chemistry at room temperature...
July 19, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28720843/clinical-study-of-genomic-drivers-in-pancreatic-ductal-adenocarcinoma
#3
Michael T Barrett, Ray Deiotte, Elizabeth Lenkiewicz, Smriti Malasi, Tara Holley, Lisa Evers, Richard G Posner, Timothy Jones, Haiyong Han, Mark Sausen, Victor E Velculescu, Jeffrey Drebin, Peter O'Dwyer, Gayle Jameson, Ramesh K Ramanathan, Daniel D Von Hoff
BACKGROUND: Pancreatic ductal adenocarcinoma (PDA) is a lethal cancer with complex genomes and dense fibrotic stroma. This study was designed to identify clinically relevant somatic aberrations in pancreatic cancer genomes of patients with primary and metastatic disease enrolled and treated in two clinical trials. METHODS: Tumour nuclei were flow sorted prior to whole genome copy number variant (CNV) analysis. Targeted or whole exome sequencing was performed on most samples...
July 18, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28717536/safety-and-efficacy-of-bipolar-energy-for-transurethral-resection-of-bladder-tumours-a-prospective-quasi-randomized-study
#4
Vasudevan Thirugnanasambandam, Jeyaraman Ramanathan
OBJECTIVE: The primary aim of the study was to evaluate the safety and efficacy of bipolar energy in resecting bladder tumors. MATERIAL AND METHODS: The study was done between March 2012 and February 2013. This is a prospective quasi-randomized study evaluating the safety and efficacy of bipolar energy in transurethral resection of bladder tumours (TURBT). Institutional Ethics Committee approval was obtained. Informed consent was taken from all patients. Patients were randomized into two groups of 50 each to undergo either monopolar TURBT or bipolar TURBT using glycine and saline irrigation solutions, respectively...
June 2017: Turkish Journal of Urology
https://www.readbyqxmd.com/read/28713598/development-of-new-deep-venous-thrombosis-while-on-apixaban
#5
Munish Sharma, Sabarina Ramanathan, Koroush Khalighi
The efficacy of novel oral anticoagulants (NOACs) in preventing deep venous thrombosis (DVT) has been established in large multicenter trials. Predictable pharmacokinetics, avoidance of routine laboratory monitoring, and lesser drug interactions have made NOACs safer and more tolerable treatment option in comparison to warfarin. However, cases of treatment failure mainly due to interindividual variation in plasma drug levels can be seen rarely. In this report we describe a case of acute DVT of right lower extremity in a patient who was on apixaban for prevention of venous thromboembolism (VTE) due to underlying nonvalvular atrial fibrillation (NVAF)...
2017: Case Reports in Cardiology
https://www.readbyqxmd.com/read/28710012/antibiofilm-activity-of-vetiveria-zizanioides-root-extract-against-methicillin-resistant-staphylococcus-aureus
#6
Arunachalam Kannappan, Shanmugaraj Gowrishankar, Ramanathan Srinivasan, Shunmugiah Karutha Pandian, Arumugam Veera Ravi
Methicillin-resistant Staphylococcus aureus (MRSA) is a leading human pathogen responsible for causing chronic clinical manifestation worldwide. In addition to antibiotic resistance genes viz. mecA and vanA, biofilm formation plays a prominent role in the pathogenicity of S. aureus by enhancing its resistance to existing antibiotics. Considering the role of folk medicinal plants in the betterment of human health from the waves of multidrug resistant bacterial infections, the present study was intended to explore the effect of Vetiveria zizanioides root on the biofilm formation of MRSA and its clinical counterparts...
July 11, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28708266/belatacept-conversion-in-an-hiv-positive-kidney-transplant-recipient-following-anti-thymocyte-globulin-induction
#7
Samatha A Kuten, Samir J Patel, Ashvin Baru, A Osama Gaber, Rustin D Crutchley, Venkataraman Ramanathan, Richard J Knight
Herein, we describe a case of early belatacept conversion in a human immunodeficiency virus (HIV)-positive kidney transplant recipient in an effort to improve suboptimal graft function and avoid drug interactions following anti-thymocyte globulin (ATG) administration. We observed improvement in renal function without HIV disease progression or opportunistic infections. Donor-specific antibodies appeared shortly after conversion but cleared without intervention. This case highlights belatacept as a means to improve renal function and avoid significant drug interactions even following ATG induction...
July 14, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28699760/preparation-of-quinazolines-via-a-2-2-2-annulation-from-aryldiazonium-salts-and-nitriles
#8
Mani Ramanathan, Shiuh-Tzung Liu
A (2+2+2) modular synthesis of multi-substituted quinazolines has been realized by the direct reaction of aryldiazonium salts with two equivalent of nitriles. Reaction of aryldiazonium salt with a nitrile provides the initial formation of a reactive nitrilium ion, which is attacked by another molecule of nitrile followed by electrophilic cyclization to deliver the desired product. Notable flexibility in the substitution patterns, readily available substrates, short reaction time, transition metal-free and gram-scale synthesis are the advantages of this method...
July 12, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28699507/quinolones-and-fluroquinolones-metabolism-and-resistance-in-salmonella-typhimurium-a-mini-review
#9
B Preethi, V Shanthi, K Ramanathan
Salmonella enterica serovars causes substantial morbidity and mortality worldwide. More than 2500 different serotypes of Salmonella were identified to date. In particular, Salmonella enterica serovar typhimurium is the most important serotype of Salmonella transmitted from animals to humans in most parts of the world. They are associated with an estimated 1 million deaths annually. Quinolones are an important class of broad-spectrum antimicrobials has been utilized in the treatment option for over 40 years...
July 10, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28695389/clinicopathological-determinants-of-an-elevated-systemic-inflammatory-response-following-elective-potentially-curative-resection-for-colorectal-cancer
#10
David G Watt, Michelle L Ramanathan, Stephen T McSorley, Killian Walley, James H Park, Paul G Horgan, Donald C McMillan
INTRODUCTION: The postoperative systemic inflammatory response (SIR) is related to both long- and short-term outcomes following surgery for colorectal cancer. However, it is not clear which clinicopathological factors are associated with the magnitude of the postoperative SIR. The present study was designed to determine the clinicopathological determinants of the postoperative systemic inflammatory response following colorectal cancer resection. METHODS: Patients with a histologically proven diagnosis of colorectal cancer who underwent elective, potentially curative resection during a period from 1999 to 2013 were included in the study (n = 752)...
July 10, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28692062/neural-reactivations-during-sleep-determine-network-credit-assignment
#11
Tanuj Gulati, Ling Guo, Dhakshin S Ramanathan, Anitha Bodepudi, Karunesh Ganguly
A fundamental goal of motor learning is to establish the neural patterns that produce a desired behavioral outcome. It remains unclear how and when the nervous system solves this 'credit assignment' problem. Using neuroprosthetic learning, in which we could control the causal relationship between neurons and behavior, we found that sleep-dependent processing was required for credit assignment and the establishment of task-related functional connectivity reflecting the casual neuron-behavior relationship. Notably, we observed a strong link between the microstructure of sleep reactivations and credit assignment, with downscaling of non-causal activity...
July 10, 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/28687321/in%C3%A2-vitro-antibiofilm-efficacy-of-piper-betle-against-quorum-sensing-mediated-biofilm-formation-of-luminescent-vibrio-harveyi
#12
Ramanathan Srinivasan, Sivasubramanian Santhakumari, Arumugam Veera Ravi
Vibrio harveyi is a potent biofilm former, which confers resistance to multiple antimicrobials, disinfectants, chemicals and biocides. The prevalence of biofilm mediated antibiotic resistance among aquatic bacterial pathogens stresses the search for novel alternative approach to treat vibriosis in aquaculture. Exploring suitable therapeutics from natural resources could be a novel area of research. Therefore, this work was executed to evaluate the inhibitory effect of Piper betle ethyl acetate extract (PBE) on bioluminescence production and biofilm formation of V...
July 4, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28681502/massive-arteriovenous-air-embolism-after-computed-tomography-guided-lung-tumour-biopsy
#13
Andrei M Beliaev, David Milne, Chris Sames, Bruce O'Brien, Tharumenthiran Ramanathan
No abstract text is available yet for this article.
July 5, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28675132/policy-and-stakeholder-analysis-of-infant-and-young-child-feeding-programmes-in-sri-lanka
#14
Sanjeeva S P Godakandage, Upul Senarath, Hiranya S Jayawickrama, Indika Siriwardena, S W A D A Wickramasinghe, Prasantha Arumapperuma, Sathyajith Ihalagama, Srisothinathan Nimalan, Ramanathan Archchuna, Claudio Umesh, Shahadat Uddin, Anne Marie Thow
BACKGROUND: Infant and young child feeding practices (IYCF) play a critical role in growth and development of children. A favourable environment supported by appropriate policies and positive contributions from all stakeholders are prerequisites for achieving optimal IYCF practices. This study aimed to assess the IYCF-related policy environment and role of stakeholders in policy making in Sri Lanka, in order to identify opportunities to strengthen the policy environment to better support appropriate IYCF and reduce childhood malnutrition...
June 13, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28670735/six3-deletions-and-incomplete-penetrance-in-families-affected-by-holoprosencephaly
#15
Bethany Stokes, Seth I Berger, Beth A Hall, Karin Weiss, Donald W Hadley, David R Murdock, Subhadra Ramanathan, Robin D Clark, Erich Roessler, Paul Kruszka, Maximilian Muenke
Holoprosencephaly (HPE) is failure of the forebrain to divide completely during embryogenesis. Incomplete penetrance has not been reported previously in SIX3 whole gene deletions which are known to cause HPE. Both chromosomal microarray and whole exome sequencing (WES) were used to evaluated families with inherited HPE. Two families showed inherited deletions that contain SIX3 and were incompletely penetrant for HPE. Using WES, we ruled out parental mosaicism, a SIX3 hypomorph, and clinically significant variants in genes that are known to interact with SIX3 as causes of incomplete penetrance...
July 2, 2017: Congenital Anomalies
https://www.readbyqxmd.com/read/28666577/use-of-evidence-based-therapy-for-cardiovascular-risk-factors-in-canadian-outpatients-with-atrial-fibrillation-from-the-facilitating-review-and-education-to-optimize-stroke-prevention-in-atrial-fibrillation-freedom-af-and-co-ordinated-national-network-to-engage
#16
Alexandra Silberberg, Mary K Tan, Andrew T Yan, Paul Angaran, Paul Dorian, Claudia Bucci, Jean C Gregoire, Alan D Bell, David J Gladstone, Martin S Green, Peter L Gross, Allan Skanes, Andrew M Demchuk, Charles R Kerr, L Brent Mitchell, Jafna L Cox, Mario Talajic, Vidal Essebag, Brett Heilbron, Krishnan Ramanathan, Carl Fournier, Bruce H Wheeler, Peter J Lin, Murray Berall, Anatoly Langer, Lianne Goldin, Shaun G Goodman
Using data collected from 2 national atrial fibrillation (AF) primary care physician chart audits (Facilitating Review and Education to Optimize Stroke Prevention in Atrial Fibrillation [FREEDOM AF] and Co-ordinated National Network to Engage Physicians in the Care and Treatment of Patients With Atrial Fibrillation [CONNECT AF]), we evaluated the frequency of, and factors associated with, the use of cardiovascular (CV) evidence-based therapies in Canadian AF outpatients with at least 1 CV risk factor or co-morbidity...
June 1, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28661299/legal-epidemiology-the-science-of-law
#17
Tara Ramanathan, Rachel Hulkower, Joseph Holbrook, Matthew Penn
The importance of legal epidemiology in public health law research has undoubtedly grown over the last five years. Scholars and practitioners together have developed guidance on best practices for the field, including: placing emphasis on transdisciplinary collaborations; creating valid, reliable, and repeatable research; and publishing timely products for use in decision-making and change. Despite the energy and expertise researchers have brought to this important work, they name significant challenges in marshalling the diverse skill sets, quality controls, and funding to implement legal epidemiology activities...
March 2017: Journal of Law, Medicine & Ethics: a Journal of the American Society of Law, Medicine & Ethics
https://www.readbyqxmd.com/read/28660099/presurgery-weight-loss-goals-depressive-symptoms-and-weight-loss-among-women-undergoing-bariatric-surgery
#18
Kyle E Freese, Andrew D Althouse, Ramesh Ramanathan, Robert P Edwards, Dana H Bovbjerg, Faina Linkov
Purpose: To determine whether preoperative weight loss goals are associated with postoperative weight loss and whether the effect is modified by preoperative depressive symptoms. Methods: Sixty-three women from an ongoing cohort study who were undergoing first-time bariatric surgery at a large, academic hospital in Pittsburgh, PA, were included in this subanalysis. They were assessed preoperatively and 12 months postoperatively in regard to anthropometric and biobehavioral factors. Multivariable linear regression models were used to estimate associations between weight loss goals, expressed as percentage excess body mass index loss (%EBMIL), and postoperative %EBMIL, as well as test effect modification by depressive symptoms...
June 1, 2017: Bariatric Surgical Practice and Patient Care
https://www.readbyqxmd.com/read/28658986/ocrelizumab-a-b-cell-depleting-therapy-for-multiple-sclerosis
#19
Dejan Jakimovski, Bianca Weinstock-Guttman, Murali Ramanathan, Channa Kolb, David Hojnacki, Alireza Minagar, Robert Zivadinov
Multiple sclerosis (MS) is the most common neurological disease responsible for early disability in the young working population. In the last two decades, based on retrospective/prospective data, the use of disease-modifying therapies has been shown to slow the rate of disability progression and prolonged the time to conversion into secondary-progressive MS (SPMS). However, despite the availability of several approved therapies, disability progression cannot be halted significantly in all MS patients. Areas covered: This article reviews the immunopathology of the B-cells, and their role in pathogenesis of MS and their attractiveness as a potential therapeutic target in MS...
July 3, 2017: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/28645485/eli-ruckenstein-a-rare-researcher-teacher-and-mentor-par-excellence
#20
EDITORIAL
Yun Hang Hu, Ramanathan Nagarajan, Paschalis Alexandridis
No abstract text is available yet for this article.
June 2017: Advances in Colloid and Interface Science
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