keyword
MENU ▼
Read by QxMD icon Read
search

Ramanathan

keyword
https://www.readbyqxmd.com/read/28088083/specificity-and-stability-of-transient-protein-protein-interactions
#1
REVIEW
Sneha Vishwanath, Anshul Sukhwal, Ramanathan Sowdhamini, Narayanaswamy Srinivasan
Remarkable features that are achieved in a protein-protein complex to precise levels are stability and specificity. Deviation from the normal levels of specificity and stability, which is often caused by mutations, could result in disease conditions. Chemical nature, 3-D arrangement and dynamics of interface residues code for both specificity and stability. This article reviews roles of interfacial residues in transient protein-protein complexes. It is proposed that aside from hotspot residues conferring stability to the complex, a small set of 'rigid' residues at the interface that maintain conformation between complexed and uncomplexed forms, play a major role in conferring specificity...
January 11, 2017: Current Opinion in Structural Biology
https://www.readbyqxmd.com/read/28087490/longitudinal-multiple-sclerosis-lesion-segmentation-resource-challenge
#2
Aaron Carass, Snehashis Roy, Amod Jog, Jennifer L Cuzzocreo, Elizabeth Magrath, Adrian Gherman, Julia Button, James Nguyen, Ferran Prados, Carole H Sudre, Manuel Jorge Cardoso, Niamh Cawley, Olga Ciccarelli, Claudia A M Wheeler-Kingshott, Sébastien Ourselin, Laurence Catanese, Hrishikesh Deshpande, Pierre Maurel, Olivier Commowick, Christian Barillot, Xavier Tomas-Fernandez, Simon K Warfield, Suthirth Vaidya, Abhijith Chunduru, Ramanathan Muthuganapathy, Ganapathy Krishnamurthi, Andrew Jesson, Tal Arbel, Oskar Maier, Heinz Handels, Leonardo O Iheme, Devrim Unay, Saurabh Jain, Diana M Sima, Dirk Smeets, Mohsen Ghafoorian, Bram Platel, Ariel Birenbaum, Hayit Greenspan, Pierre-Louis Bazin, Peter A Calabresi, Ciprian M Crainiceanu, Lotta M Ellingsen, Daniel S Reich, Jerry L Prince, Dzung L Pham
In conjunction with the ISBI 2015 conference, we organized a longitudinal lesion segmentation challenge providing training and test data to registered participants. The training data consisted of five subjects with a mean of 4.4 time-points, and test data of fourteen subjects with a mean of 4.4 time-points. All 82 data sets had the white matter lesions associated with multiple sclerosis delineated by two human expert raters. Eleven teams submitted results using state-of-the-art lesion segmentation algorithms to the challenge, with ten teams presenting their results at the conference...
January 10, 2017: NeuroImage
https://www.readbyqxmd.com/read/28077523/autologous-adipose-derived-mesenchymal-stem-cells-improve-healing-of-coiled-experimental-saccular-aneurysms-an-angiographic-and-histopathological-study
#3
Aymeric Rouchaud, Waleed Brinjikji, Daying Dai, Yong-Hong Ding, Tina Gunderson, Dana Schroeder, Laurent Spelle, David F Kallmes, Ramanathan Kadirvel
PURPOSE: Long-term occlusion of coiled aneurysms frequently fails, probably because of poor intrasaccular healing and inadequate endothelialization across the aneurysm neck. The purpose of this study was to determine if attachment of autologous mesenchymal stem cells (MSCs) to platinum coils would improve the healing response in an elastase-induced aneurysm model in rabbits. MATERIALS AND METHODS: With approval from the institutional animal care and use committee, aneurysms were created in rabbits and embolized with control platinum coils (Axium; Medtronic) (n=6) or coils seeded ex vivo with autologous adipose-tissue MSCs (n=7)...
January 11, 2017: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/28074945/solid-state-nmr-at-natural-isotopic-abundance-for-the-determination-of-conformational-polymorphism-the-case-of-designed-%C3%AE-turn-peptides-containing-di-prolines
#4
Jayasubba Reddy Yarava, Rajesh Sonti, K Kantharaju, S Raghothama, K V Ramanathan
The proton double quantum-carbon single quantum correlation experiment has been applied to designed peptides in the solid state in natural isotopic abundance. Analogous to nOe studies in solution, through-space double-quantum connectivities have been exploited to obtain the cis-trans conformational polymorphism of diproline residues occurring at β-turns in the peptides.
January 11, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28062977/angiopoietin-pathway-gene-expression-associated-with-poor-breast-cancer-survival
#5
Rajesh Ramanathan, Amy L Olex, Mikhail Dozmorov, Harry D Bear, Leopoldo Jose Fernandez, Kazuaki Takabe
PURPOSE: Angiogenesis is one of the hallmarks of cancer and is essential for cancer progression and metastasis. However, clinical trials with vascular endothelial growth factor (VEGF) pathway inhibitors have failed to show overall survival benefit in breast cancer. Targeted therapy against the angiopoietin pathway, a downstream angiogenesis cascade, could be effective in breast cancer. This study investigates the association of angiopoietin pathway gene expression with breast cancer survival using a "big data" approach employing RNA sequencing data from The Cancer Genome Atlas (TCGA)...
January 6, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28031588/assessment-of-suicidal-intent
#6
Rajkumar Ramanathan, Arul Saravanan Ramachandran, Kalaivani Periasamy, Kala Saminathan
BACKGROUND: Suicide and suicidal attempt are an important cause of mortality and denotes severe morbidity among the population. Successful suicide attempt is associated with previous suicide attempts. Identifying factors in suicide attempters will help in formulating a comprehensive response to these issues. OBJECTIVE: To identify the sub group who are more vulnerable and the factors associated with this group. SETTING AND DESIGN: A cross sectional observational study of this sub group was carried out...
November 2016: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/28024869/expression-of-heat-shock-proteins-hsps-in-aedes-aegypti-l-and-aedes-albopictus-skuse-diptera-culicidae-larvae-in-response-to-thermal-stress
#7
Arun Sivan, Ananganallur Nagarajan Shriram, Nagarajan Muruganandam, Ramanathan Thamizhmani
Climatic changes are responsible, to a certain extent for the occurrence and spread of arboviral pathogens world over. Temperature is one of the important abiotic factors influencing the physiological processes of mosquitoes. Several genes of heat shock protein (HSP) families are known to be expressed in mosquitoes, which aid in overcoming stress induced by elevated temperature. In order to understand expression of HSP family genes in the Andaman population of Aedes aegypti and Aedes albopictus, we used quantitative real-time polymerase chain reaction (qPCR) to examine expression levels of HSPs in response to thermal stress under laboratory and in actual field conditions...
December 24, 2016: Acta Tropica
https://www.readbyqxmd.com/read/28024598/design-and-characterization-of-3d-hybrid-collagen-matrixes-as-a-dermal-substitute-in-skin-tissue-engineering
#8
Giriprasath Ramanathan, Sivakumar Singaravelu, Thangavelu Muthukumar, Sitalakshmi Thyagarajan, Paramasivan Thirumalai Perumal, Uma Tiruchirapalli Sivagnanam
The highly interconnected porous dressing material was fabricated with the utilization of novel collagen (COL-SPG) for the efficient healing of the wound. Herein, we report the fabrication of 3D collagen impregnated with bioactive extract (COL-SPG-CPE) to get rid of infection at the wound site. The resultant 3D collagen matrix was characterized physiochemically using Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and mechanical property. The dressing substrate possesses the high swelling ability, increase in the porosity, in vitro enzymatic degradability and antibacterial property...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28008675/exploring-%C3%AE-tubulin-inhibitors-from-plant-origin-using-computational-approach
#9
Kanika Verma, Kaavya Kannan, Shanthi V, Sethumadhavan R, Karthick V, Ramanathan K
INTRODUCTION: β-Tubulin is an important target for the binding of anti-cancer drugs, in particular, paclitaxel (taxol), vinblastine and epothilone. However, mutations in β-tubulin structure give resistance to chemotherapeutic agents. Notably, mutations at R306C, F270 V, L217R, L228F, A185T and A248V positions in β-tubulin give high resistance for paclitaxel binding. OBJECTIVE: To discover novel inhibitors of β-tubulin from natural sources, particularly alkaloids, using a virtual screening approach...
December 23, 2016: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28008387/role-of-ph-monitoring-in-laryngopharyngeal-reflux-patients-with-voice-disorders
#10
Swati Maldhure, Ramanathan Chandrasekharan, Amit-Kumar Dutta, Ashok Chacko, Mary Kurien
INTRODUCTION: Laryngopharyngeal reflux (LPR) is considered an important cause of voice disorder. We aimed to determine the frequency of LPR in patients with voice disorder and the association between Koufman Reflux Symptom Index (RSI), Reflux Finding Score (RFS), gastroesophageal reflux disease (GERD), and proximal acid reflux in these patients. MATERIALS AND METHODS: We performed a prospective study in patients aged more than 18 years presenting at the ear, nose, and throat (ENT) clinic with a change in voice lasting more than 3 weeks...
November 2016: Iranian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28004880/electrohydrodynamic-induced-sers-immunoassay-for-extensive-multiplexed-biomarker-sensing
#11
Khondakar Kamil Reza, Jing Wang, Ramanathan Vaidyanathan, Shuvashis Dey, Yuling Wang, Matt Trau
Cancer diagnosis and patient monitoring require sensitive and simultaneous measurement of multiple cancer biomarkers considering that single biomarker analysis present inadequate information on the underlying biological transformations. Thus, development of sensitive and selective assays for multiple biomarker detection might improve clinical diagnosis and expedite the treatment process. Herein, a microfluidic platform for the rapid, sensitive, and parallel detection of multiple cancer-specific protein biomarkers from complex biological samples is presented...
December 22, 2016: Small
https://www.readbyqxmd.com/read/28003660/clinical-implementation-of-integrated-genomic-profiling-in-patients-with-advanced-cancers
#12
Mitesh J Borad, Jan B Egan, Rachel M Condjella, Winnie S Liang, Rafael Fonseca, Nicole R Ritacca, Ann E McCullough, Michael T Barrett, Katherine S Hunt, Mia D Champion, Maitray D Patel, Scott W Young, Alvin C Silva, Thai H Ho, Thorvardur R Halfdanarson, Robert R McWilliams, Konstantinos N Lazaridis, Ramesh K Ramanathan, Angela Baker, Jessica Aldrich, Ahmet Kurdoglu, Tyler Izatt, Alexis Christoforides, Irene Cherni, Sara Nasser, Rebecca Reiman, Lori Cuyugan, Jacquelyn McDonald, Jonathan Adkins, Stephen D Mastrian, Riccardo Valdez, Dawn E Jaroszewski, Daniel D Von Hoff, David W Craig, A Keith Stewart, John D Carpten, Alan H Bryce
DNA focused panel sequencing has been rapidly adopted to assess therapeutic targets in advanced/refractory cancer. Integrated Genomic Profiling (IGP) utilising DNA/RNA with tumour/normal comparisons in a Clinical Laboratory Improvement Amendments (CLIA) compliant setting enables a single assay to provide: therapeutic target prioritisation, novel target discovery/application and comprehensive germline assessment. A prospective study in 35 advanced/refractory cancer patients was conducted using CLIA-compliant IGP...
December 2016: Scientific Reports
https://www.readbyqxmd.com/read/27997078/hiding-in-plain-sight-a-case-of-ornithine-transcarbamylase-deficiency-unmasked-post-liver-transplantation
#13
Meera Ramanathan, Suresh Uppalapu, Nayan M Patel
Ornithine transcarbamylase deficiency represents the most common inherited defect of the urea cycle. This enzyme, predominantly found in the liver, plays a crucial role in recycling free ammonia, with deficiencies often leading to fatal complications. Here, we present the case of a 63-year-old male with alcoholic cirrhosis who underwent orthotopic liver transplantation, gradual worsening of his mental status and progressive elevation of ammonia levels. Liver allograft function was deemed normal, raising concern for a donor derived metabolic disorder of the urea cycle...
December 20, 2016: American Journal of Transplantation
https://www.readbyqxmd.com/read/27993352/constructing-a-molecular-theory-of-self-assembly-interplay-of-ideas-from-surfactants-and-block-copolymers
#14
Ramanathan Nagarajan
Low molecular weight surfactants and high molecular weight block copolymers display analogous self-assembly behavior in solutions and at interfaces, generating nanoscale structures of different shapes. Understanding the link between the molecular structure of these amphiphiles and their self-assembly behavior has been the goal of theoretical studies. Despite the analogies between surfactants and block copolymers, models predicting their self-assembly behavior have evolved independent of one another, each overlooking the molecular feature considered critical to the other...
December 9, 2016: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/27991895/pre-existing-invasive-fungal-infection-is-not-a-contraindication-for-allogeneic-hsct-for-patients-with-hematologic-malignancies-a-cibmtr-study
#15
R T Maziarz, R Brazauskas, M Chen, A A McLeod, R Martino, J R Wingard, M Aljurf, M Battiwalla, C C Dvorak, B Geroge, E C Guinan, G A Hale, H M Lazarus, J-W Lee, J L Liesveld, M Ramanathan, V Reddy, B N Savani, F O Smith, L Strasfeld, R A Taplitz, C Ustun, M J Boeckh, J Gea-Banacloche, C A Lindemans, J J Auletta, M L Riches
Patients with prior invasive fungal infection (IFI) increasingly proceed to allogeneic hematopoietic cell transplantation (HSCT). However, little is known about the impact of prior IFI on survival. Patients with pre-transplant IFI (cases; n=825) were compared with controls (n=10247). A subset analysis assessed outcomes in leukemia patients pre- and post 2001. Cases were older with lower performance status (KPS), more advanced disease, higher likelihood of AML and having received cord blood, reduced intensity conditioning, mold-active fungal prophylaxis and more recently transplanted...
December 19, 2016: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/27988073/longitudinal-trajectories-of-cortical-thickness-as-a-biomarker-for-psychosis-in-individuals-with-22q11-2-deletion-syndrome
#16
Seetha Ramanathan, Leah M Mattiaccio, Ioana L Coman, Jo-Anna C Botti, Wanda Fremont, Stephen V Faraone, Kevin M Antshel, Wendy R Kates
OBJECTIVE: 22q11.2 deletion syndrome (DS) or velo-cardio-facial syndrome (VCFS) is a genetic condition that has been identified as the highest genetic risk factor for developing psychotic illnesses. This unique biological nature of 22q11DS provides a valuable opportunity to explore predictive biomarkers of psychosis. In this study, we examined the relationship of cortical thickness and surface area between various brain regions and prodromal symptoms of psychosis. METHODS: 75 probands with 22q11DS, 32 age-matched controls and 28 siblings underwent MRIs over 2 or 3 timepoints...
December 14, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27982660/randomness-amplification-under-minimal-fundamental-assumptions-on-the-devices
#17
Ravishankar Ramanathan, Fernando G S L Brandão, Karol Horodecki, Michał Horodecki, Paweł Horodecki, Hanna Wojewódka
Recently, the physically realistic protocol amplifying the randomness of Santha-Vazirani sources producing cryptographically secure random bits was proposed; however, for reasons of practical relevance, the crucial question remained open regarding whether this can be accomplished under the minimal conditions necessary for the task. Namely, is it possible to achieve randomness amplification using only two no-signaling components and in a situation where the violation of a Bell inequality only guarantees that some outcomes of the device for specific inputs exhibit randomness? Here, we solve this question and present a device-independent protocol for randomness amplification of Santha-Vazirani sources using a device consisting of two nonsignaling components...
December 2, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27970265/tct-102-association-between-operator-experience-with-access-type-in-percutaneous-coronary-intervention-and-outcomes-in-patients-with-acute-coronary-syndrome-a-network-meta-analysis-of-randomized-controlled-trials
#18
Rahman Shah, Inyong Hwang Hwang, Mannu Nayyar, Ellis Christian, Kodangudi Ramanathan, Abdul Rashid
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27934158/soft-x-ray-spectroscopy-of-a-complex-heterojunction-in-high-efficiency-thin-film-photovoltaics-intermixing-and-zn-speciation-at-the-zn-o-s-cu-in-ga-se2-interface
#19
Michelle Mezher, Rebekah Garris, Lorelle M Mansfield, Monika Blum, Dirk Hauschild, Kimberly Horsley, Douglas A Duncan, Wanli Yang, Marcus Bär, Lothar Weinhardt, Kannan Ramanathan, Clemens Heske
The chemical structure of the Zn(O,S)/Cu(In,Ga)Se2 interface in high-efficiency photovoltaic devices is investigated using X-ray photoelectron and Auger electron spectroscopy, as well as soft X-ray emission spectroscopy. We find that the Ga/(Ga+In) ratio at the absorber surface does not change with the formation of the Zn(O,S)/Cu(In,Ga)Se2 interface. Furthermore, we find evidence for Zn in multiple bonding environments, including ZnS, ZnO, Zn(OH)2, and ZnSe. We also observe dehydrogenation of the Zn(O,S) buffer layer after Ar(+) ion treatment...
December 7, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27930301/reprogramming-cell-fate-with-a-genome-scale-library-of-artificial-transcription-factors
#20
Asuka Eguchi, Matthew J Wleklinski, Mackenzie C Spurgat, Evan A Heiderscheit, Anna S Kropornicka, Catherine K Vu, Devesh Bhimsaria, Scott A Swanson, Ron Stewart, Parameswaran Ramanathan, Timothy J Kamp, Igor Slukvin, James A Thomson, James R Dutton, Aseem Z Ansari
Artificial transcription factors (ATFs) are precision-tailored molecules designed to bind DNA and regulate transcription in a preprogrammed manner. Libraries of ATFs enable the high-throughput screening of gene networks that trigger cell fate decisions or phenotypic changes. We developed a genome-scale library of ATFs that display an engineered interaction domain (ID) to enable cooperative assembly and synergistic gene expression at targeted sites. We used this ATF library to screen for key regulators of the pluripotency network and discovered three combinations of ATFs capable of inducing pluripotency without exogenous expression of Oct4 (POU domain, class 5, TF 1)...
December 20, 2016: Proceedings of the National Academy of Sciences of the United States of America
keyword
keyword
53856
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"