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https://www.readbyqxmd.com/read/28235401/expression-of-socs1-and-the-downstream-targets-of-its-putative-tumor-suppressor-functions-in-prostate-cancer
#1
Martin Chevrier, Diwakar Bobbala, Alberto Villalobos-Hernandez, Md Gulam Musawwir Khan, Sheela Ramanathan, Caroline Saucier, Gerardo Ferbeyre, Sameh Geha, Subburaj Ilangumaran
BACKGROUND: Suppressor of cytokine signaling 1 (SOCS1) is considered a tumor suppressor due to frequent epigenetic and micro-RNA-mediated repression of its gene expression in diverse cancers. In prostate cancer (PCa), elevated expression of miR-30d that targets SOCS1 mRNA is associated with increased risk of disease recurrence. SOCS1 can mediate its tumor suppressor functions by diverse mechanisms such as inhibiting the JAK-STAT signaling pathway, promoting the tumor suppressor functions of p53, attenuating MET receptor tyrosine kinase signaling and blocking the oncogenic potential of the cell cycle inhibitor p21(CIP1) (p21)...
February 24, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28226668/gaussian-mixture-model-for-the-identification-of-psychogenic-non-epileptic-seizures-using-a-wearable-accelerometer-sensor
#2
Shitanshu Kusmakar, Ramanathan Muthuganapathy, Bernard Yan, Terence J O'Brien, Marimuthu Palaniswami, Shitanshu Kusmakar, Ramanathan Muthuganapathy, Bernard Yan, Terence J O'Brien, Marimuthu Palaniswami, Terence J O'Brien, Shitanshu Kusmakar, Bernard Yan, Ramanathan Muthuganapathy, Marimuthu Palaniswami
Any abnormal hypersynchronus activity of neurons can be characterized as an epileptic seizure (ES). A broad class of non-epileptic seizures is comprised of Psychogenic non-epileptic seizures (PNES). PNES are paroxysmal events, which mimics epileptic seizures and pose a diagnostic challenge with epileptic seizures due to their clinical similarities. The diagnosis of PNES is done using video-electroencephalography (VEM) monitoring. VEM being a resource intensive process calls for alternative methods for detection of PNES...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28223986/gtpase-of-the-immune-associated-nucleotide-protein-5-regulates-the-lysosomal-calcium-compartment-in-t-lymphocytes
#3
Daniel Serrano, Farnaz Ghobadi, Guylain Boulay, Subburaj Ilangumaran, Christine Lavoie, Sheela Ramanathan
T lymphocytes from Gimap5(lyp/lyp) rats carrying a recessive mutation in the GTPase of immune-associated protein 5 (Gimap5) gene undergo spontaneous apoptosis. Molecular mechanisms underlying this survival defect are not yet clear. We have shown that Gimap5(lyp/lyp) T lymphocytes display reduced calcium influx following T cell antigen receptor (TCR) stimulation that was associated with impaired buffering of calcium by mitochondria. Here, we investigated the subcellular localization of GIMAP5 and its influence on Ca(2+) response in HEK293T cells and T lymphocytes...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28222335/sensitive-simultaneous-quantitation-of-testosterone-and-estradiol-in-serum-by-lc-ms-ms-without-derivatization-and-comparison-with-the-cdc-host-program
#4
Ryan C Schofield, Damodara R Mendu, Lakshmi V Ramanathan, Melissa S Pessin, Dean C Carlow
BACKGROUND: Very sensitive measurements of serum estrogens and testosterone are important in adult and pediatric endocrinology and immunoassays are known to lack the required performance at very low levels. Our aim was to develop a sensitive HPLC-MS/MS assay for both estradiol (E2) and testosterone (Te) in serum without the need for chemical derivatization and using commercially available calibrators. METHODS: Serum samples were prepared by the addition of internal standards followed by extraction using hexane:ethyl acetate...
February 10, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28215869/a-novel-assembly-pheromone-trap-for-tick-control-in-dog-kennels
#5
R K Anish, Bhaskaran Ravi Latha, Giriprasath Ramanathan, Uma Tirichurapalli Sivagnanam, C Sreekumar, V Leela
A novel ecofriendly sticky tick trap device for the control of dog tick Rhipicephalus sanguineus using gold nanoparticle assembly pheromone complex as a bait was developed. Assembly pheromones comprising of guanine, xanthine and adenine in the ratio of 25:1:1 was encapsulated in gold nanoparticle. The response of the different stages of unfed R. sanguineus ticks was evaluated using petridish bioassay. Statistical analysis was done using chi-square test. Petridish bioassay with unfed stages of R. sanguineus revealed that 100% of the larvae, nymph and adults were attracted to assembly pheromone nanogold complex within 24h...
February 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28210832/benefits-of-an-android-based-tablet-application-in-primary-screening-for-eye-diseases-in-a-rural-population-india
#6
Sayed Ahmed Imtiaz, Sannapaneni Krishnaiah, Sunil Kumar Yadav, Balasubramaniam Bharath, Ramanathan V Ramani
To investigate the effectiveness, efficiency and cost gains in collecting patient eye health information from remote rural villages of India by trained field investigators through an Android Based Tablet Application namely 'Sankara Electronic Remote Vision Information System (SERVIS)". During January and March 2016, a population based cross-sectional study was conducted in three Indian states employing SERVIS and manual method. The SERVIS application has a 48-items survey instrument programed into the application...
April 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28199224/interview-with-ramanathan-raju-md-fache-facs-president-and-ceo-of-nyc-health-hospitals
#7
(no author information available yet)
No abstract text is available yet for this article.
November 2016: Journal of Healthcare Management / American College of Healthcare Executives
https://www.readbyqxmd.com/read/28198662/changes-in-bacterial-epidemiology-and-antibiotic-resistance-among-veterans-with-spinal-cord-injury-disorder-over-the-past-9-years
#8
Margaret A Fitzpatrick, Katie J Suda, Nasia Safdar, Stephen P Burns, Makoto M Jones, Linda Poggensee, Swetha Ramanathan, Charlesnika T Evans
OBJECTIVE: Patients with spinal cord injury and disorder (SCI/D) have an increased risk of infection with multidrug-resistant (MDR) bacteria. We described bacterial epidemiology and resistance in patients with SCI/D at Veterans Affairs Medical Centers (VAMCs) for the past 9 years. DESIGN: Retrospective cohort Setting: One hundred thirty VAMCs. PARTICIPANTS: Veterans with SCI/D and bacterial cultures with antibiotic susceptibility testing performed between 1/1/2005-12/31/2013...
February 15, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28198037/performance-of-contemporary-surgical-risk-scores-for-mitral-valve-surgery
#9
Tom Kai Ming Wang, Sophie Harmos, Greg D Gamble, Tharumenthiran Ramanathan, Peter N Ruygrok
BACKGROUND: Risk stratification for mitral valve repair or replacement (MVR) is important in the decision-making for treating several mitral valve disease but is rarely studied. We compared the prognostic utility of EuroSCORE, EuroSCORE II, and Society of Thoracic Surgeons (STS) Score for MVR. METHODS: The three scores were retrospectively calculated for consecutive patients undergoing isolated MVR at Auckland City Hospital during 2005-2012 and their discrimination and calibration for mortality and morbidities assessed...
February 15, 2017: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/28196994/distressing-cutaneous-lesion-among-bipolar-affective-disorder-patients-on-lithium-therapy-a-retrospective-cross-sectional-study
#10
Syed Ummar, B Lakshmi Dorai, Shree Aarthi Ramanathan
AIM: To assess the incidence of cutaneous lesion in bipolar affective disorder (BPAD) patients on lithium therapy. To evaluate the relationship between duration of lithium therapy, dosage of lithium, serum lithium level, and cutaneous lesions. To assess whether reduction/stoppage of dose of lithium has any change in the course of cutaneous side effects. To look for a relationship between addition of isotretinoin and the course of mood disorder. METHODOLOGY: We retrospectively collected hospital case records of 125 consecutive BPAD patients initiated lithium therapy, assessed with inclusion and exclusion criteria...
October 2016: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/28186887/accelerated-singular-value-based-ultrasound-blood-flow-clutter-filtering-with-randomized-singular-value-decomposition-rsvd-and-randomized-spatial-downsampling
#11
Pengfei Song, Joshua Trzasko, Armando Manduca, Bo Qiang, Ramanathan Kadirvel, David Kallmes, Shigao Chen
Singular value decomposition (SVD)-based ultrasound blood flow clutter filters have recently demonstrated substantial improvement in clutter rejection for ultrafast plane wave microvessel imaging, and have become the commonly used clutter filtering method for many novel ultrafast imaging applications such as functional ultrasound and super-resolution imaging. At present, however, the computational burden of SVD remains as a major hurdle for practical implementation and clinical translation of this method. To address this challenge, in the study we present two blood flow clutter filtering methods based on randomized singular value decomposition (rSVD) and randomized spatial downsampling to accelerate SVD clutter filtering with minimal compromise to the clutter filter performance...
February 7, 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28169292/risk-factors-for-community-associated-multidrug-resistant-pseudomonas-aeruginosa-in-veterans-with-spinal-cord-injury-and-disorder-a-retrospective-cohort-study
#12
I O Kale, M A Fitzpatrick, K J Suda, S P Burns, L Poggensee, S Ramanathan, R Sabzwari, C T Evans
STUDY DESIGN: Retrospective cohort studyObjectives:To identify independent risk factors associated with community-associated multidrug-resistant Psedomonas aeruginosa (MDRPA) in a population of veterans with spinal cord injury and disorders (SCI/D). SETTING: A total of 127 Veterans Affairs healthcare facilities. METHODS: Laboratory results from 1 January 2012 to 31 December 2013 were collected, and MDRPA cultures were compared with non-MDRPA cultures...
February 7, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28165480/%C3%AE-lipoic-acid-treatment-prevents-cystine-urolithiasis-in-a-mouse-model-of-cystinuria
#13
Tiffany Zee, Neelanjan Bose, Jarcy Zee, Jennifer N Beck, See Yang, Jaspreet Parihar, Min Yang, Sruthi Damodar, David Hall, Monique N O'Leary, Arvind Ramanathan, Roy R Gerona, David W Killilea, Thomas Chi, Jay Tischfield, Amrik Sahota, Arnold Kahn, Marshall L Stoller, Pankaj Kapahi
Cystinuria is an incompletely dominant disorder characterized by defective urinary cystine reabsorption that results in the formation of cystine-based urinary stones. Current treatment options are limited in their effectiveness at preventing stone recurrence and are often poorly tolerated. We report that the nutritional supplement α-lipoic acid inhibits cystine stone formation in the Slc3a1(-/-) mouse model of cystinuria by increasing the solubility of urinary cystine. These findings identify a novel therapeutic strategy for the clinical treatment of cystinuria...
February 6, 2017: Nature Medicine
https://www.readbyqxmd.com/read/28163578/author-s-reply
#14
Aravind S K Ramanathan, Prabha Senguttuvan, Vel Prakash, Appasamy Vengadesan, Rajendiran Padmaraj
No abstract text is available yet for this article.
January 2017: Journal of Family & Community Medicine
https://www.readbyqxmd.com/read/28162857/design-synthesis-and-biological-evaluation-of-2-4-phenylthiazol-2-yl-isoindoline-1-3-dione-derivatives-as-anti-prostate-cancer-agents
#15
K Saravanan, R Elancheran, S Divakar, S Athavan Alias Anand, M Ramanathan, Jibon Kotoky, N K Lokanath, S Kabilan
The structural modification and molecular docking-based screening approaches on thiazole-based isoindolinediones were imposed to find the novel 2-(4-phenylthiazol-2-yl) isoindoline-1,3-dione derivatives. The best fit compounds (6a-n) were synthesized and evaluated their antiproliferative activities on the prostate cancer cell lines (PC-3 & LNCaP). Among them, the compound, 6m exhibited good activity, particularly on LNCaP (IC50=5.96±1.6μM), moderately active against PC-3 cell lines as compared to bicalutamide...
January 25, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28159813/correlation-between-ferumoxytol-uptake-in-tumor-lesions-by-mri-and-response-to-nanoliposomal-irinotecan-in-patients-with-advanced-solid-tumors-a-pilot-study
#16
Ramesh K Ramanathan, Ronald Korn, Natarajan Raghunand, Jasgit C Sachdev, Ronald G Newbold, Gayle Jameson, Gerald J Fetterly, Joshua Prey, Stephan G Klinz, Jaeyeon Kim, Jason Cain, Bart S Hendriks, Daryl C Drummond, Eliel Bayever, Jonathan B Fitzgerald
PURPOSE: Determine if deposition characteristics of ferumoxytol (FMX) iron nanoparticles in tumors, identified by quantitative MRI, may predict tumor lesion response to nanoliposomal irinotecan (nal-IRI). EXPERIMENTAL DESIGN: Eligible patients with previously treated solid tumors had FMX-MRI scans before and following (1, 24, and 72 hours) FMX injection. After MRI acquisition, R2* signal was used to calculate FMX levels in plasma, reference tissue and tumor lesions by comparison with a phantom-based standard curve...
February 3, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28151586/nuclear-erythroid-2-related-factor-2-activation-inhibits-house-dust-mite-induced-sinonasal-epithelial-cell-barrier-dysfunction
#17
Nyall R London, Anuj Tharakan, Andrew P Lane, Shyam Biswal, Murugappan Ramanathan
BACKGROUND: Dysregulated sinonasal epithelial cell (SNEC) barrier function has been proposed to contribute to the pathogenesis of sinonasal inflammatory conditions such as allergic rhinitis (AR) and chronic rhinosinusitis (CRS). Allergens such as house dust mite (HDM) have been reported to disrupt SNEC barrier integrity. We have recently identified nuclear erythroid 2-related factor 2 (Nrf2) activation via sulforaphane (SFN) stimulation to stabilize SNEC barrier function. The purpose of this study was to explore whether Nrf2 activation could ameliorate HDM-induced SNEC barrier dysfunction...
February 2, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28149064/effect-of-a-12-week-yoga-therapy-program-on-mental-health-status-in-elderly-women-inmates-of-a-hospice
#18
Meena Ramanathan, Ananda Balayogi Bhavanani, Madanmohan Trakroo
AIM AND OBJECTIVES: This study was undertaken to evaluate the effectiveness of yoga on the mental health status of elderly women inmates residing in a hospice in Puducherry. MATERIALS AND METHODS: Forty elderly women were randomly divided into yoga and wait-listed control group. A yoga therapy program of 60 min was given twice a week for 12 weeks. This protocol was specially designed for senior citizens, keeping in mind their health status and physical limitations that included simple warm-up and breath-body movement coordination practices (jathis and kriyas), static stretching postures (asanas), breathing techniques (pranayamas), and relaxation...
January 2017: International Journal of Yoga
https://www.readbyqxmd.com/read/28135240/pericyte-degeneration-leads-to-neurovascular-uncoupling-and-limits-oxygen-supply-to-brain
#19
Kassandra Kisler, Amy R Nelson, Sanket V Rege, Anita Ramanathan, Yaoming Wang, Ashim Ahuja, Divna Lazic, Philbert S Tsai, Zhen Zhao, Yi Zhou, David A Boas, Sava Sakadžić, Berislav V Zlokovic
Pericytes are perivascular mural cells of brain capillaries. They are positioned centrally in the neurovascular unit between endothelial cells, astrocytes and neurons. This position allows them to regulate key neurovascular functions of the brain. The role of pericytes in the regulation of cerebral blood flow (CBF) and neurovascular coupling remains, however, under debate. Using loss-of-function pericyte-deficient mice, here we show that pericyte degeneration diminishes global and individual capillary CBF responses to neuronal stimuli, resulting in neurovascular uncoupling, reduced oxygen supply to the brain and metabolic stress...
March 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/28117948/bactericidal-antibiotics-promote-oxidative-damage-and-programmed-cell-death-in-sinonasal-epithelial-cells
#20
Michael A Kohanski, Anuj Tharakan, Nyall R London, Andrew P Lane, Murugappan Ramanathan
BACKGROUND: Antibiotics are widely and heavily used in the treatment of chronic sinusitis. Bactericidal antibiotics can stimulate reactive oxygen species (ROS) formation, a proinflammatory response, and cell death in cultured human sinonasal epithelial cells (SNECs). Sulforaphane (SFN) is a potent stimulator of the antioxidant nuclear factor erythroid 2-related factor 2 (Nrf-2) system and a suppressor of inflammation. In this study we utilized SFN to further explore the relationship between levofloxacin treatment, ROS formation, and the cell death response...
January 24, 2017: International Forum of Allergy & Rhinology
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