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https://www.readbyqxmd.com/read/29457976/radiosynthesis-and-in-vivo-evaluation-of-11c-mpc-6827-the-first-brain-penetrant-microtubule-pet-ligand
#1
J S Dileep Kumar, Kiran Kumar Solingapuram Sai, Jaya Prabhakaran, Hakeem R Oufkir, Gayathri Ramanathan, Christopher T Whitlow, Hima Dileep, Akiva Mintz, J John Mann
Abnormalities of microtubules (MTs) are implicated in the pathogenesis of many CNS diseases. Despite the potential of an MT imaging agents, no PET ligand is currently available for in vivo imaging of MTs in the brain. We radiolabeled [11C]MPC-6827, a high affinity MTA, demonstrated its specific binding in rat and mice brain using PET imaging. Our experiments show that [11C]MPC-6827 has specific binding to MT in brain, and it is the first MT-binding PET ligand.
February 19, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29456230/isolated-renal-involvement-of-cytomegalovirus-inclusion-disease-in-an-infant
#2
Subramaniam Murugananth, Rajendran Padmaraj, Natarajan Gopalakrishnan, Rajendran Manorajan, Anila Abraham Kurien, Jeyachandran Dhanapriya, Thanigachalam Dineshkumar, Ramanathan Sakthirajan
Cytomegalovirus (CMV) is the most common cause of congenital infections in humans occurring in 1% of all liveborns. Symptomatic congenital CMV infection involves multiple systems and causes significant morbidity and mortality in newborns. Isolated CMV infection of the kidneys in a living infant has not been reported in literature. Here, we report an infant who presented only with renomegaly and renal biopsy showed extensive CMV inclusions. Serum and urine polymerase chain reaction for CMV were positive, and CMV involvement of other organs was ruled out...
January 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29454250/disulphide-linkage-to-get-cleaved-or-not-bulk-and-nano-copper-based-sers-of-cystine
#3
Arathi P J, Bhaskar Seemesh, Rajendra Kumar Reddy G, Suresh Kumar P, Ramanathan V
Different nano-structures of noble metals have been the conventional substrates for carrying out Surface Enhanced Raman Spectroscopy (SERS). In this paper we examine electrodeposited copper (Cu) nano-structures on pencil graphite as novel substrate to carry out SERS measurements by considering l-cystine (Cys-Cys) (dimer of the amino acid cysteine) as the probe. The formation of monolayer of the probe molecule on the substrates was confirmed using cyclic voltammetric measurements. Mode of adsorption of Cys-Cys was observed to be different on bulk Cu (taken in the wire form) and nano-structured Cu on pencil graphite...
February 5, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29451787/effect-of-methyl-substitution-on-the-n-h%C3%A2-%C3%A2-%C3%A2-o-interaction-in-complexes-of-pyrrole-with-water-methanol-and-dimethyl-ether-matrix-isolation-infrared-spectroscopy-and-ab-initio-computational-studies
#4
Shubhra Sarkar, Nagarajan Ramanathan, Kalyanasundaram Sundararajan
Hydrogen bonded interactions of pyrrole with water and methanol have been studied using matrix isolation infrared spectroscopy and compared with the calculation performed on dimethyl ether. Computations carried out at MP2/aug-cc-pVDZ level of theory yielded two minima for the pyrrole-water and pyrrole-methanol complexes. The global and local minima correspond to the N-H∙∙∙O and O-H∙∙∙π complexes, respectively, where the N-H group of pyrrole interacts with oxygen of water/methanol and O-H of water and methanol interacts with the π cloud of pyrrole...
February 16, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29448938/comparative-genomic-analysis-of-ten-clinical-streptococcus-pneumoniae-collected-from-a-malaysian-hospital-reveal-31-new-unique-drug-resistant-snps-using-whole-genome-sequencing
#5
Hassan Mahmood Jindal, Babu Ramanathan, Cheng Foh Le, Ranganath Gudimella, Rozaimi Razali, Rishya Manikam, Shamala Devi Sekaran
BACKGROUND: Streptococcus pneumoniae or pneumococcus is a leading cause of morbidity and mortality worldwide, specifically in relation to community-acquired pneumonia. Due to the overuse of antibiotics, S. pneumoniae has developed a high degree of resistance to a wide range of antibacterial drugs. METHODS: In this study, whole genome sequencing (WGS) was performed for 10 clinical strains of S. pneumoniae with different levels of sensitivity to standard antibiotics...
February 15, 2018: Journal of Biomedical Science
https://www.readbyqxmd.com/read/29446919/evolution-of-nio-island-size-distributions-during-the-oxidation-of-a-ni-5cr-alloy-experiment-and-modeling
#6
Rohit Ramanathan, Gopalakrishnan Ramalingam, John H Perepezko, Petra Reinke, Peter W Voorhees
The classic models of metal oxidation developed by Wagner, and Cabrera and Mott presuppose the existence of a planar oxide film and develop expressions for the rate at which the film thickens. Missing from those models is a description of how that initially planar film forms. Using STM, we study the growth of NiO islands on the (100) surface of a Ni-5Cr alloy during the oxidation regime where the initial planar film is formed as oxide islands. The island height and area distributions as a function of the oxygen exposure in Langmuirs (1 L = 10 -6 Torr-s) are measured...
February 15, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29439739/sex-difference-in-clot-lysability-and-association-to-coronary-artery-calcification
#7
Ramshanker Ramanathan, Niels Peter R Sand, Johannes J Sidelmann, Bjarne L Nørgaard, Jørgen B Gram
BACKGROUND: Incidence and prevalence of cardiovascular disease (CVD) differ between sexes, and women experience CVD later than men. Changes in fibrin clot lysability are associated with CVD, and the present study addresses sex differences in fibrin clot lysability in asymptomatic middle-aged individuals and the relation to coronary artery calcification (CAC). METHODS: Participants free of morbidities and medication, N = 163, were randomly chosen from a national registry among citizens, 50 or 60 years of age, and were followed for 5 years...
February 13, 2018: Biology of Sex Differences
https://www.readbyqxmd.com/read/29431875/phytosynthesized-silver-nanoparticles-as-anti-quorum-sensing-and-antibiofilm-agent-against-the-nosocomial-pathogen-serratia-marcescens-an-in-vitro-study
#8
Durgadevi Ravindran, Srinivasan Ramanathan, Kannappan Arunachalam, Godfred Ponraj Jeyaraj, Karutha Pandian Shunmugiah, Veera Ravi Arumugam
AIM: Serratia marcescens is an important multidrug-resistant human pathogen. The pathogenicity of S. marcescens mainly depends on the Quorum Sensing (QS) mechanism, which regulates the virulence factors production and biofilm formation. Hence, targeting QS mechanism in S. marcescens will ultimately pave the way to combat its pathogenicity. Thus, the present study is intended to evaluate the efficacy of Vetiveria zizanioides root extract mediated silver nanoparticles (AgNPs) as a potent anti-QS and antibiofilm agent against S...
February 12, 2018: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29431814/correction-the-photocatalytic-role-of-electrodeposited-copper-on-pencil-graphite
#9
Arathi P J, Seemesh Bhaskar, Rajendra Kumar Reddy G, Suresh Kumar P, Ramanathan V
Correction for 'The photocatalytic role of electrodeposited copper on pencil graphite' by Arathi P. J. et al., Phys. Chem. Chem. Phys., 2018, 20, 3430-3432.
February 12, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29424324/nano-medicine-as-a-newly-emerging-approach-to-combat-human-immunodeficiency-virus-hiv
#10
Muthupandian Saravanan, Tsehaye Asmalash, Atsebaha Gebrekidan, Dawit Gebreegziabiher, Tadele Araya, Haftamu Hilekiros, Hamed Barabadi, Kumaresan Ramanathan
BACKGROUND: Human Immuno deficiency Virus (HIV) infection has attained pandemic level due to its complexity on both the HIV infection cycle and on the targets for drug delivery. This limits medication and consequently requires prominent and promising drug delivery systems to be invented. Notably, various nanomaterial have been studied to enhance effective delivery of the antiretroviral drugs for HIV prevention, diagnosis and cure. Some of these nanomaterials are liposomes, dendrimers, inorganic nanoparticles (NPs), polymeric micelles, natural and synthetic polymers...
February 8, 2018: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/29413683/presence-of-oxygen-and-mitochondria-in-skeletal-muscle-early-postmortem
#11
Eric M England, Sulaiman K Matarneh, Rachel M Mitacek, Anupam Abraham, Ranjith Ramanathan, Jordan C Wicks, Hao Shi, Tracy L Scheffler, Emily M Oliver, Emma T Helm, David E Gerrard
Anaerobic glycolysis dominates energy metabolism postmortem. Even so, however, recent studies suggest mitochondria can modify postmortem energy metabolism and may contribute to pH decline, possibly affecting the transformation of muscle to meat and fresh meat quality development. Because oxygen is a necessary component of mitochondrial function, oxygenation of porcine and bovine longissimus thoracis et lumborum was determined postmortem using NIR spectroscopy. The ratio of oxy- to deoxymyoglobin decreased with time postmortem in both species...
February 1, 2018: Meat Science
https://www.readbyqxmd.com/read/29404986/predictors-of-short-term-readmission-after-pancreaticoduodenectomy
#12
Rajesh Ramanathan, Travis Mason, Luke G Wolfe, Brian J Kaplan
BACKGROUND: Readmissions are a common complication after pancreaticoduodenectomy and are increasingly being used as a performance metric affecting quality assessment, public reporting, and reimbursement. This study aims to identify general and pancreatectomy-specific factors contributing to 30-day readmission after pancreaticoduodenectomy, and determine the additive value of incorporating pancreatectomy-specific factors into a large national dataset. METHODS: Prospective American College of Surgeons-National Surgical Quality Improvement Project (ACS-NSQIP) data were retrospectively analyzed for patients who underwent pancreaticoduodenectomy (PD) between 2011 and 2015...
February 5, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29404698/novel-derivatives-of-1-2-3-triazole-cannabinoid-1-receptor-ligands-modulate-gastrointestinal-motility-in-mice
#13
Agata Szymaszkiewicz, Marta Zielinska, Kun Li, Mani Ramanathan, Safiul Alam, Duen-Ren Hou, Jakub Fichna, Martin Storr
Cannabinoid-1 (CB1) receptors are broadly distributed in the central and peripheral nervous systems; among others, they are located in the enteric nervous system. In the gastrointestinal (GI) system, they participate in regulation of intestinal motility or ion transport. The aim of our study was to assess the effect of 1,2,3-triazole derivatives (compound 1: 2-[4,5-bis(2,4-dichlorophenyl)-2H-1,2,3-triazol-2-yl]-N-(2-fluorobenzyl)acetamide, compound 2: 2-[4,5-bis(2,4-dichlorophenyl)-2H-1,2,3-triazol-2-yl]-N-(4-fluorobenzyl)acetamide, compound 3: N-benzyl-2-[4-(4-chlorophenyl)-5-(2,4-dichlorophenyl)-2H-1,2,3-triazol-2-yl]acetamide]), characterized in vitro as CB1 antagonists with high CB1 over CB2 selectivity, in the mouse GI tract...
February 5, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29402248/acute-and-sub-acute-oral-toxicity-of-dracaena-cinnabari-resin-methanol-extract-in-rats
#14
Nashwan Abdullah Al-Afifi, Aied Mohammed Alabsi, Marina Mohd Bakri, Anand Ramanathan
BACKGROUND: Dracaena cinnabari (DC) is a perennial tree that located on the Southern coast of Yemen native to the Socotra Island. This tree produces a deep red resin known as the Dragon's blood, the Twobrother's Blood or Damm Alakhwain. The current study performed to evaluate the safety of the DC resin methanol extract after a single or 28 consecutive daily oral administrations. METHODS: In assessing the safety of DC resin methanol extract, acute and sub-acute oral toxicity tests performed following OECD guidelines 423 and 407, respectively, with slight modifications...
February 5, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29400715/rna-protein-interaction-detection-in-living-cells
#15
Muthukumar Ramanathan, Karim Majzoub, Deepti S Rao, Poornima H Neela, Brian J Zarnegar, Smarajit Mondal, Julien G Roth, Hui Gai, Joanna R Kovalski, Zurab Siprashvili, Theo D Palmer, Jan E Carette, Paul A Khavari
RNA-protein interactions play numerous roles in cellular function and disease. Here we describe RNA-protein interaction detection (RaPID), which uses proximity-dependent protein labeling, based on the BirA* biotin ligase, to rapidly identify the proteins that bind RNA sequences of interest in living cells. RaPID displays utility in multiple applications, including in evaluating protein binding to mutant RNA motifs in human genetic disorders, in uncovering potential post-transcriptional networks in breast cancer, and in discovering essential host proteins that interact with Zika virus RNA...
February 5, 2018: Nature Methods
https://www.readbyqxmd.com/read/29400711/pericyte-degeneration-causes-white-matter-dysfunction-in-the-mouse-central-nervous-system
#16
Axel Montagne, Angeliki M Nikolakopoulou, Zhen Zhao, Abhay P Sagare, Gabriel Si, Divna Lazic, Samuel R Barnes, Madelaine Daianu, Anita Ramanathan, Ariel Go, Erica J Lawson, Yaoming Wang, William J Mack, Paul M Thompson, Julie A Schneider, Jobin Varkey, Ralf Langen, Eric Mullins, Russell E Jacobs, Berislav V Zlokovic
Diffuse white-matter disease associated with small-vessel disease and dementia is prevalent in the elderly. The biological mechanisms, however, remain elusive. Using pericyte-deficient mice, magnetic resonance imaging, viral-based tract-tracing, and behavior and tissue analysis, we found that pericyte degeneration disrupted white-matter microcirculation, resulting in an accumulation of toxic blood-derived fibrin(ogen) deposits and blood-flow reductions, which triggered a loss of myelin, axons and oligodendrocytes...
February 5, 2018: Nature Medicine
https://www.readbyqxmd.com/read/29391312/a-simplified-technique-of-esophageal-self-expandable-metallic-stent-placement-without-fluoroscopic-and-endoscopic-guidance-for-treating-esophageal-carcinoma
#17
Ratnakar Kini, Sabarinathan Ramanathan, Pugazhendhi Thangavel, Premkumar Karunakaran, Kani Shaik Mohamed, Murali Ananthavadivelu
BACKGROUND/AIMS: Self-expandable metallic stent (SEMS) placement with fluoroscopic guidance is a commonly used technique to relieve obstruction in patients with esophageal carcinoma. However, it has disadvantages such as radiation exposure. SEMS placement with endoscopic guidance also has the disadvantages of causing discomfort to patients as the endoscope and SEMS assembly are simultaneously used and it needs two experts for the procedure to be performed. To overcome these disadvantages, a simplified technique for SEMS placement was developed that does not require fluoroscopic or endoscopic guidance...
January 2018: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/29389649/improved-super-resolution-ultrasound-microvessel-imaging-with-spatiotemporal-nonlocal-means-filtering-and-bipartite-graph-based-microbubble-tracking
#18
Pengfei Song, Joshua D Trzasko, Armando Manduca, Runqing Huang, Ramanathan Kadirvel, David F Kallmes, Shigao Chen
Super-resolution ultrasound microvessel imaging with contrast microbubbles has recently been proposed by multiple studies, demonstrating outstanding resolution with high potential for clinical applications. This paper aims at addressing the potential noise issue in in vivo human super-resolution imaging with ultrafast plane-wave imaging. The rich spatiotemporal information provided by ultrafast imaging presents features that allow microbubble signals to be separated from background noise. In addition, the high-frame-rate recording of microbubble data enables the implementation of robust tracking algorithms commonly used in particle tracking velocimetry...
February 2018: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/29387138/tocotrienol-is-a-cardioprotective-agent-against-ageing-associated-cardiovascular-disease-and-its-associated-morbidities
#19
REVIEW
Nardev Ramanathan, Esther Tan, Li Jun Loh, Boon Seng Soh, Wei Ney Yap
Ageing is a nonmodifiable risk factor that is linked to increased likelihood of cardiovascular morbidities. Whilst many pharmacological interventions currently exist to treat many of these disorders such as statins for hypercholesterolemia or beta-blockers for hypertension, the elderly appear to present a greater likelihood of suffering non-related side effects such as increased risk of developing new onset type 2 diabetes (NODM). In some cases, lower efficacy in the elderly have also been reported. Alternative forms of treatment have been sought to address these issues, and there has been a growing interest in looking at herbal remedies or plant-based natural compounds...
2018: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29386740/epithelial-cyst-of-spleen-presenting-as-hypersplenism
#20
Jayant Kumar Banerjee, Ramanathan Saranga Bharathi, S Venkatesan, Giriraj Singh
No abstract text is available yet for this article.
January 2018: Medical Journal, Armed Forces India
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