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Ramanathan

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https://www.readbyqxmd.com/read/28448794/principles-of-systems-biology-no-16
#1
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This month: how T cells signal in binary (Vale), advances in interaction mapping (Greenleaf/Sabatini/Ahroni/Bodenmiller), single-cell RNA-seq (Suvà/Ramanathan/Marioni), and more (Hilvert/Wong/Chisholm).
April 26, 2017: Cell Systems
https://www.readbyqxmd.com/read/28448625/structural-and-functional-studies-of-ferredoxin-and-oxygenase-components-of-3-nitrotoluene-dioxygenase-from-diaphorobacter-sp-strain-ds2
#2
Archana Kumari, Deepak Singh, S Ramaswamy, Gurunath Ramanathan
3-nitrotoluene dioxygenase (3NTDO) from Diaphorobacter sp. strain DS2 catalyses the conversion of 3-nitrotoluene (3NT) into a mixture of 3- and 4-methylcatechols with release of nitrite. We report here, X-ray crystal structures of oxygenase and ferredoxin components of 3NTDO at 2.9 Å and 2.4 Å, respectively. The residues responsible for nitrite release in 3NTDO were further probed by four single and two double mutations in the catalytic site of α-subunit of the dioxygenase. Modification of Val 350 to Phe, Ile 204 to Ala, and Asn258 to Val by site directed mutagenesis resulted in inactive enzymes revealing the importance of these residues in catalysis...
2017: PloS One
https://www.readbyqxmd.com/read/28445901/comparative-pharmacokinetics-of-cholecalciferol-in-dogs-from-2-different-oral-formulations-using-corrective-measures-to-overcome-interference-from-endogenous-cholecalciferol
#3
Harilal Patel, Prakash Patel, Chandrakant Bhatt, Ashok Ghoghari, Urvesh Patel, Mukesh Ukawalal, Shafiq Sheikh, Vikram Ramanathan, Nuggehally R Srinivas
The aim of the preclinical investigation was to obtain single dose pharmacokinetics in dogs from 2 different oral cholecalciferol formulations using corrective measures to overcome the interference of endogenous cholecalciferol. 6 dogs were fasted overnight and the following day received 60 000 IU dose cholecalciferol [reference, Eris(®), vs. test, Sunbless(®)] by oral dosing. Blood samples were collected on day 0 (baseline establishment) and after dosing on day 1 up to 28 days. The serum samples were extracted using protein precipitation/solid phase extraction and analysed to determine cholecalciferol by LC-MS/MS assay with calibrators prepared from cholecalciferol free serum...
April 26, 2017: Drug Research
https://www.readbyqxmd.com/read/28442605/the-toll-like-receptor-4-antagonist-eritoran-protects-mice-from-lethal-filovirus-challenge
#4
Patrick Younan, Palaniappan Ramanathan, Jessica Graber, Fabian Gusovsky, Alexander Bukreyev
The 2013-2016 outbreak of Ebola virus (EBOV) in West Africa, which has seen intermittent reemergence since it was officially declared over in February of 2016, has demonstrated the need for the rapid development of therapeutic intervention strategies. Indirect evidence has suggested that the EBOV infection shares several commonalities associated with the onset of bacterial sepsis, including the development of a "cytokine storm." Eritoran, a Toll-like receptor 4 (TLR4) antagonist, was previously shown to result in protection of mice against lethal influenza virus infection...
April 25, 2017: MBio
https://www.readbyqxmd.com/read/28436427/broad-and-potent-cross-clade-neutralizing-antibodies-with-multiple-specificities-in-the-plasma-of-hiv-1-subtype-c-infected-individuals
#5
Narayanaiah Cheedarla, K Lucia Precilla, Hemalatha Babu, K K Vidya Vijayan, Manickam Ashokkumar, Padmapriyadarsini Chandrasekaran, Nandagopal Kailasam, Jagadish Chandrabose Sundaramurthi, Soumya Swaminathan, Viswanath Buddolla, S Kalyanaraman Vaniambadi, V D Ramanathan, Luke Elizabeth Hanna
Broadly Cross clade Neutralizing (BCN) antibodies are recognized as potential therapeutic tools and leads for the design of a vaccine that can protect human beings against various clades of Human Immunodeficiency Virus (HIV). In the present study, we screened plasma of 88 HIV-1 infected ART naïve individuals for their neutralization potential using a standard panel of 18 pseudoviruses belonging to different subtypes and different levels of neutralization. We identified 12 samples with good breadth of neutralization (neutralized >90% of the viruses)...
April 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28435136/chitosan-enhances-nanoparticle-delivery-from-the-reproductive-tract-to-target-draining-lymphoid-organs
#6
Jaehyung Park, Renuka Ramanathan, Linhchi Pham, Kim A Woodrow
To prime adaptive immune responses from the female reproductive tract (FRT), particulate antigens must be transported to draining lymph nodes (dLNs) since there are no local organized lymphoid structures equivalent to those found in the respiratory or gastrointestinal tracts. However, little is known about how to safely and effectively navigate successive barriers to transport such as crossing the epithelium and gaining access to migratory cells and lymphatic drainage that provide entry into dLNs. Here, we demonstrate that intravaginal pre-treatment with chitosan significantly facilitates translocation of nanoparticles (NPs) across the multilayered vaginal epithelium to target dLNs...
April 20, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28432603/immunoprophylaxis-of-multi-antigen-peptide-map-vaccine-for-human-lymphatic-filariasis
#7
Christiana Immanuel, Aparnaa Ramanathan, Malathi Balasubramaniyan, Vishal Kishor Khatri, Nitin Purushottam Amdare, Donthamsetty Nageswara Rao, Maryada Venkata Rami Reddy, Kaliraj Perumal
Human lymphatic filariasis, the parasitic disease caused by the filarial nematodes Wuchereria bancrofti, Brugia malayi, and Brugia timori, is ranked as the second most complex clinical condition leading to permanent and long-term disability. The multiple antigen peptide (MAP) approach is an effective method to chemically synthesize and deliver multiple T and B cell epitopes as the constituents of a single immunogen. Here, we report on the design, chemical synthesis, and immunoprophylaxis of three epitopes that have been identified from promising vaccine candidates reported in our previous studies, constructed as MAP on an inert lysine core for human lymphatic filariasis in Jird model...
April 21, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28430473/first-direct-detection-constraints-on-ev-scale-hidden-photon-dark-matter-with-damic-at-snolab
#8
A Aguilar-Arevalo, D Amidei, X Bertou, M Butner, G Cancelo, A Castañeda Vázquez, B A Cervantes Vergara, A E Chavarria, C R Chavez, J R T de Mello Neto, J C D'Olivo, J Estrada, G Fernandez Moroni, R Gaïor, Y Guardincerri, K P Hernández Torres, F Izraelevitch, A Kavner, B Kilminster, I Lawson, A Letessier-Selvon, J Liao, A Matalon, V B B Mello, J Molina, P Privitera, K Ramanathan, Y Sarkis, T Schwarz, M Settimo, M Sofo Haro, R Thomas, J Tiffenberg, E Tiouchichine, D Torres Machado, F Trillaud, X You, J Zhou
We present direct detection constraints on the absorption of hidden-photon dark matter with particle masses in the range 1.2-30  eV c^{-2} with the DAMIC experiment at SNOLAB. Under the assumption that the local dark matter is entirely constituted of hidden photons, the sensitivity to the kinetic mixing parameter κ is competitive with constraints from solar emission, reaching a minimum value of 2.2×10^{-14} at 17  eV c^{-2}. These results are the most stringent direct detection constraints on hidden-photon dark matter in the galactic halo with masses 3-12  eV c^{-2} and the first demonstration of direct experimental sensitivity to ionization signals <12  eV from dark matter interactions...
April 7, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28427457/integrative-modelling-of-tir-domain-containing-adaptor-molecule-inducing-interferon-%C3%AE-trif-provides-insights-into-its-autoinhibited-state
#9
Jarjapu Mahita, Ramanathan Sowdhamini
BACKGROUND: TRIF is a key protein in antiviral innate immunity, operating downstream of TLRs. TRIF activation leads to the production of interferon-β and pro-inflammatory cytokines. There is evidence from experiments to suggest that the N-terminal domain of TRIF binds to its TIR domain to avoid constitutive activation. However, no structure of a complex between the N-terminal domain and the TIR domain exists till date. The disordered nature of the region connecting the N-terminal domain and the TIR domain compounds the issue of elucidating the mechanism of autoinhibition of TRIF...
April 20, 2017: Biology Direct
https://www.readbyqxmd.com/read/28417250/impact-of-surface-roughness-on-dielectrophoretically-assisted-concentration-of-microorganisms-over-pcb-based-platforms
#10
Geeta Bhatt, Rishi Kant, Keerti Mishra, Kuldeep Yadav, Deepak Singh, Ramanathan Gurunath, Shantanu Bhattacharya
This article presents a PCB based microfluidic platform for performing a dielectrophoretic capture of live microorganisms over inter-digitated electrodes buried under layers of different surface roughness values. Although dielectrophoresis has been extensively studied earlier over silicon and polymer surfaces with printed electrodes the issue of surface roughness particularly in case of buried electrodes has been seldom investigated. We have addressed this issue through a layer of spin coated PDMS (of various surface roughness) that is used to cover the printed electrodes over a printed circuit board...
June 2017: Biomedical Microdevices
https://www.readbyqxmd.com/read/28413786/surgical-management-of-bronchopulmonary-carcinoids-a-single-center-experience
#11
Ashish Jakhetiya, Pankaj Kumar Garg, Rambha Pandey, Palaniappan Ramanathan, Sunil Kumar, Debojit Nath, Durgatosh Pandey
INTRODUCTION: Bronchopulmonary carcinoids are uncommon tumors with relatively indolent biological behavior but a distinct malignant potential. Surgery is the mainstay of treatment. Our aim was to study preoperative characteristics, surgical approaches, and outcome in patients with bronchopulmonary carcinoid tumors. PATIENTS AND METHODS: This retrospective study was done in the Department of Surgical Oncology of a Tertiary Teaching Hospital of North India. The case records of all the patients who underwent surgical treatment for lung neoplasms and were diagnosed to have bronchopulmonary carcinoids were reviewed...
January 2017: South Asian Journal of Cancer
https://www.readbyqxmd.com/read/28411641/nanoarmoring-of-proteins-by-conjugation-to-block-copolymer-micelles
#12
Nisaraporn Suthiwangcharoen, Ramanathan Nagarajan
The creation of polymer nanoparticles with protein functionality is of great interest to many applications such as targeted drug or gene delivery, diagnostic imaging, cancer theranostics, delivery of protein therapeutics, sensing chemical and biomolecular analytes in complex environments, and design of protective clothing resembling a second skin. Many approaches to achieving this goal are being explored in the current literature. In this chapter, we describe a relatively simple and flexible approach of conjugating the protein to an amphiphilic block copolymer and creating polymer nanoparticles with protein functionality by taking advantage of the intrinsic self-assembly behavior of the amphiphilic block copolymer...
2017: Methods in Enzymology
https://www.readbyqxmd.com/read/28408711/a-randomized-controlled-trial-to-determine-the-appropriate-time-to-initiate-peritoneal-dialysis-after-insertion-of-catheter-timely-pd-study
#13
Dwarakanathan Ranganathan, George John, Edward Yeoh, Nicola Williams, Barry O'Loughlin, Thin Han, Lakshman Jeyaseelan, Ramanathan Kavitha, Helen Healy
♦Background: The optimal time for the commencement of peritoneal dialysis (PD) after PD catheter insertion is unclear. If dialysis is started too soon after insertion, dialysate leaks and infection could occur. However, by starting PD earlier, morbidity and costs can be reduced through lesser hemodialysis requirements. This is the first randomized controlled trial to determine the safest and shortest interval to commence PD after catheter insertion. ♦ Methods: All consecutive patients undergoing PD catheter insertion at the Royal Brisbane and Women's Hospital and Rockhampton Hospital from 1 March 2008 to 31 May 2013 who met the inclusion and exclusion criteria were invited to participate in the trial...
April 13, 2017: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/28407252/combined-endonasal-and-eyelid-approach-for-management-of-extensive-frontal-sinus-inverting-papilloma
#14
Monirah Albathi, Murugappan Ramanathan, Andrew P Lane, Kofi D O Boahene
OBJECTIVES: Sinonasal inverting papilloma (IP) is a benign but locally aggressive mucosal neoplasm with a high recurrence rate. Extension into the frontal sinus presents surgical challenges for endonasal resection. This study presents an orbitofrontal approach for managing extensive IP. STUDY DESIGN: Case series. METHODS: Four patients seen between 2012 and 2016 with biopsy-proven IP with lateral frontal sinus extension underwent a combined endonasal and transpalpebral approach for tumor resection...
April 13, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28405932/synthesis-characterization-and-solvatochromic-studies-using-the-solvent-polarity-parameter-ent-on-2-chloro-3-ethylamino-1-4-naphthoquinone
#15
Arulappan Durairaj, Asir Obadiah, Subramanian Ramanathan, Princy Merlin Johnson, Antony Paulraj Bella, Samuel Vasanthkumar
Quinones are molecules with varied biological activities and electronic properties which are used for important applications [1, 2]. Quinone with a heteroatom substituted, namely 2-chloro-3-ethylamino-1,4-naphthoquinone (N-CAN) was synthesized and characterized by various techniques such as H(1)-NMR, C(13)-NMR, Mass spectroscopy and FT-IR spectroscopy. In this study, the solvatochromic effects on the spectral properties of 2-chloro-3-ethylamino-1,4-naphthoquinone have been investigated in different solvents taking into consideration, the solvent parameters like dielectric constant (ε) and refractive index (η) of different solvent polarities...
April 12, 2017: Journal of Fluorescence
https://www.readbyqxmd.com/read/28403781/design-synthesis-and-biological-evaluation-of-novel-1-3-thiazolidine-2-4-diones-as-anti-prostate-cancer-agents
#16
Ramakrishnan Elancheran, Kuppusamy Saravanan, Selvaraj Divakar, Sima Kumari, V Lenin Maruthanila, Senthamarikannan Kabilan, Muthaiah Ramanathan, Rajlakshmi Devi, Jibon Kotoky
Androgen receptor (AR) is an attractive target for the treatment of prostate cancer. Structural modification and molecular docking-based virtual screening approaches were imposed to identify the novel 1,3-thiazolidine-2,4-diones (TZDs) by using Schrödinger (Maestro 9.5). The best fit molecules (3-12 & 23-31) were synthesized and characterized using spectroscopic techniques, then in vitro antioxidant and anti-prostate cancer activities were evaluated. Further, the structure of the intermediate (18) was confirmed by single crystal XRD analysis...
April 12, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28401469/bioactive-amento-flavone-isolated-from-cassia-fistula-l-leaves-exhibits-therapeutic-efficacy
#17
M Srividhya, H Hridya, V Shanthi, K Ramanathan
Novel natural compounds endowed with sound bioactivities are currently the utmost need as leads toward drug discovery. For the first time, here, we report the presence of Amentoflavone (biflavonoid) in the leaves of Cassia fistula L. Structural characterization was carried out using ultraviolet-visible spectrophotometer, Fourier transform infrared, nuclear magnetic resonance, and thin-layer chromatography. The isolated compound was further evaluated for its bioactivity. The compound demonstrated moderate cytotoxicity in liver carcinoma (HepG2) cells, and the comparative analysis for the standard and normal compound has also been validated...
May 2017: 3 Biotech
https://www.readbyqxmd.com/read/28393781/comparison-of-levosimendan-versus-dobutamine-in-patients-with-moderate-to-severe-left-ventricular-dysfunction-undergoing-off-pump-coronary-artery-bypass-grafting-a-randomized-prospective-study
#18
Ashok Kandasamy, Hariharan Antony Simon, P Murthy, Mahalakshmi Annadurai, Mushkath Mohamed Ali, Gayathri Ramanathan
CONTEXT: Recent upsurge in referral of patients with compromised left ventricular (LV) function for cardiac surgery has led to an increasing use inotropes to achieve improvement of tissue perfusion in the perioperative period. AIMS AND OBJECTIVES: To compare the hemodynamic effects and immediate postoperative outcomes with levosimendan and dobutamine in patients with moderate to severe LV dysfunction undergoing off-pump coronary artery bypass grafting (OPCAB). SETTINGS AND DESIGN: University teaching hospital, randomized control study...
April 2017: Annals of Cardiac Anaesthesia
https://www.readbyqxmd.com/read/28389086/developing-eco-friendly-biofungicide-for-the-management-of-major-seed-borne-diseases-of-rice-and-assessing-their-physical-stability-and-storage-life
#19
Ramasamy Naveenkumar, Arjunan Muthukumar, Ganesan Sangeetha, Ramanathan Mohanapriya
Three plant oils (Cymbopogon citratus, Cymbopogon martini, and Pelargonium graveolens) were developed as EC formulations and tested for their physical stabilities. EC formulations (10EC, 20EC and 30EC) of C. citratus, C. martini and P. graveolens had emulsion stability, spontaneity property, heat and cold stability. EC formulated plant oils were screened against the major seed borne fungi of rice such as Curvularia lunata, Fusarium moniliforme, Bipolaris oryzae, and Sarocladium oryzae. The level of inhibition varied among the concentrations of EC formulations...
April 4, 2017: Comptes Rendus Biologies
https://www.readbyqxmd.com/read/28384287/genome-wide-profiling-in-oral-squamous-cell-carcinoma-identifies-a-four-genetic-marker-signature-of-prognostic-significance
#20
Vui King Vincent-Chong, Iman Salahshourifar, Kar Mun Woo, Arif Anwar, Rozaimi Razali, Ranganath Gudimella, Zainal Ariff Abdul Rahman, Siti Mazlipah Ismail, Thomas George Kallarakkal, Anand Ramanathan, Wan Mahadzir Wan Mustafa, Mannil Thomas Abraham, Keng Kiong Tay, Rosnah Binti Zain
BACKGROUND: Cancers of the oral cavity are primarily oral squamous cell carcinomas (OSCCs). Many of the OSCCs present at late stages with an exceptionally poor prognosis. A probable limitation in management of patients with OSCC lies in the insufficient knowledge pertaining to the linkage between copy number alterations in OSCC and oral tumourigenesis thereby resulting in an inability to deliver targeted therapy. OBJECTIVES: The current study aimed to identify copy number alterations (CNAs) in OSCC using array comparative genomic hybridization (array CGH) and to correlate the CNAs with clinico-pathologic parameters and clinical outcomes...
2017: PloS One
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