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JOURNAL ARTICLE
Sandra Eugênia Coutinho, Raimunda Sinthia Lima de Braga, André Külzer Santos, Joanna Scopel Velho, Denise Rossato Silva
Smoking has been recognized as a significant risk factor for COVID-19 and mortality. The World Health Organization (WHO) has recommended smoking cessation to reduce the impact of COVID-19. This study aimed to evaluate the smoking cessation rate of patients starting tuberculosis (TB) treatment at six months using motivational interviewing based on the WHO "five steps to quit" model. In addition, we assessed the knowledge about smoking and the barriers to smoking cessation. We conducted a retrospective cohort study...
April 24, 2024: Monaldi Archives for Chest Disease
#22
JOURNAL ARTICLE
Wanyu Jia, Xue Zhang, Peng Li, Ruiyang Sun, Daobin Wang, Chunlan Song
INTRODUCTION: The occurrence of pulmonary consolidation in children with Mycoplasma pneumoniae pneumonia (MPP) can lead to exacerbation of the disease. Therefore, early identification of children with MPP in combination with pulmonary consolidation is critical. The purpose of this study was to develop a straightforward, easy-to-use online dynamic nomogram for the identification of children with MPP who are at high risk of developing pulmonary consolidation. METHODS: 491 MPP patients were chosen and divided randomly into a training cohort and an internal validation cohort at a 4:1 ratio...
April 24, 2024: European Journal of Clinical Microbiology & Infectious Diseases
#23
JOURNAL ARTICLE
Finja Möller, Malte Oetting, Andreas Spiegel, Olaf Zube, Thilo Bertsche
PURPOSE: In many countries, outpatient and inpatient care are separated. During hospitalization, therefore, switching the outpatient medication to medication of the hospital formulary is required. METHODS: We newly designed a switching algorithm in six switching steps (S0-S5) and conducted a study at Bundeswehr Hospital Hamburg (300 beds, 80% civilians). We performed (i) a medication reconciliation to obtain information on outpatient medications and (ii) a medication review to solve drug-related-problems, e...
April 24, 2024: European Journal of Clinical Pharmacology
#24
REVIEW
Lidia Engel, Valeriia Sokolova, Ekaterina Bogatyreva, Anna Leuenberger
PURPOSE: Proxy assessment can be elicited via the proxy-patient perspective (i.e., asking proxies to assess the patient's quality of life (QoL) as they think the patient would respond) or proxy-proxy perspective (i.e., asking proxies to provide their own perspective on the patient's QoL). This review aimed to identify the role of the proxy perspective in explaining the differences between self-rated and proxy-rated QoL in people living with dementia. METHODS: A systematic literate review was conducted by sourcing articles from a previously published review, supplemented by an update of the review in four bibliographic databases...
April 24, 2024: Quality of Life Research
#25
JOURNAL ARTICLE
Alexis LeVee, Megan Wong, Sarah Flores, Nora Ruel, Heather McArthur, James Waisman, Joanne Mortimer
BACKGROUND: The addition of pembrolizumab (pembro) to neoadjuvant chemotherapy (NAC) is standard of care for the treatment of early triple-negative breast cancer (TNBC) after KEYNOTE-522 trial demonstrated improved pathologic complete response (pCR) rates with the combination. However, the optimal treatment strategy for TNBC remains uncertain as questions persist about which patients benefit from pembro and the best treatment schedule and regimen. We identified real-world clinical characteristics and treatment variables associated with response to NAC plus pembro...
April 24, 2024: Oncologist
#26
JOURNAL ARTICLE
McKenzie A Dirr, Areeba Ahmed, Daniel I Schlessinger, Misha Haq, Victoria Shi, Eric Koza, Melissa Ma, Rachel E Christensen, Sarah A Ibrahim, Jochen Schmitt, Lena Johannsen, Yuka Asai, Hilary E Baldwin, Enzo Berardesca, Brian Berman, Ana Carolina Vieira, Anna L Chien, David E Cohen, James Q Del Rosso, Jacquelyn Dosal, Lynn A Drake, Steven R Feldman, Alan B Fleischer, Adam Friedman, Emmy Graber, Julie C Harper, Yolanda R Helfrich, Gregor B Jemec, Sandra M Johnson, Rajani Katta, Peter Lio, Lisa E Maier, George Martin, Arielle R Nagler, Isaac M Neuhaus, Melis Palamar, Lawrence C Parish, Theodore Rosen, Stephen P Shumack, James A Solomon, Emil A Tanghetti, Guy F Webster, Allison Weinkle, Jonathan S Weiss, Edward J Wladis, Ian A Maher, Joseph F Sobanko, Todd V Cartee, Brian A Cahn, Murad Alam, Bianca Y Kang, Sanjana Iyengar, Noor Anvery, Erkan Alpsoy, Anthony Bewley, Clio Dessinioti, Alexander Egeberg, Burhan Engin, Harald P M Gollnick, Dimitrios Ioannides, Hei Sung Kim, Elizabeth Lazaridou, Ji Li, Hester Gail Lim, Giuseppe Micali, Clivia Maria Moraes de Oliveira, Lucero Noguera-Morel, Aurora Parodi, Markus Reinholz, Dae Hun Suh, Qiuning Sun, Esther J van Zuuren, Uwe Wollina, Youwen Zhou, Catherine Zip, Emily Poon, Ross Pearlman
IMPORTANCE: Inconsistent reporting of outcomes in clinical trials of rosacea is impeding and likely preventing accurate data pooling and meta-analyses. There is a need for standardization of outcomes assessed during intervention trials of rosacea. OBJECTIVE: To develop a rosacea core outcome set (COS) based on key domains that are globally relevant and applicable to all demographic groups to be used as a minimum list of outcomes for reporting by rosacea clinical trials, and when appropriate, in clinical practice...
April 24, 2024: JAMA Dermatology
#27
JOURNAL ARTICLE
Daniel H Strauss, Natalie M Davoodi, Linda J Resnik, Sarah Keene, Peter T Serina, Elizabeth M Goldberg
BACKGROUND AND PURPOSE: Falls are the leading reason for injury-related emergency department (ED) visits for older adults. The Geriatric Acute and Post-acute Fall Prevention Intervention (GAPcare), an in-ED intervention combining a medication therapy management session delivered by a pharmacist and a fall risk assessment and plan by a physical therapist, reduced ED revisits at 6 months among older adults presenting after a fall. Our objective was to evaluate the relationship between measures of function obtained in the ED and clinical outcomes...
April 24, 2024: Journal of Geriatric Physical Therapy
#28
REVIEW
Amal S A F Hafez, Fatma M Elgazzar, Zahraa K Sobh, Ahmad A El-Ebiary
Some studies suggested that gastrointestinal (GIT) decontamination with oil may improve the prognosis of patients who ingested aluminum phosphide (AlP). The aim of this study is to compare the efficacy and safety of gastric lavage with oil-based solutions to any method of gastric decontamination not using oils in patients presenting with acute AlP poisoning. The literature was searched for English-published randomized controlled trials (RCTs) from inception to 16 September 2023. The searched electronic databases included MEDLINE/PubMed, Cochrane Library, Web of Science, Egyptian Knowledge Bank, Scopus, and Google Scholar...
April 24, 2024: Critical Reviews in Toxicology
#29
JOURNAL ARTICLE
Yangyang Yang, Xiaoyan Yin, Yuanzhuo Zhang, Lei Ren
PURPOSE: Construction of a prediction model to predict the risk of major adverse cardiovascular events (MACE) in the long term after percutaneous coronary intervention (PCI) in patients with acute ST-segment elevation myocardial infarction (STEMI). METHOD: Retrospective analysis of STEMI patients treated with PCI from April 2018 to April 2021 in Fuyang People's Hospital. Lasso regression was used to screen the risk factors for the first occurrence of MACE in patients, and multifactorial logistic regression analysis was used to construct a prediction model...
April 25, 2024: Coronary Artery Disease
#30
JOURNAL ARTICLE
Laura Butragueño-Laiseca, Iñaki F Troconiz, Santiago Grau, Nuria Campillo, Belén Padilla, Sarah Nicole Fernández, María Slöcker, Laura Herrera, María José Santiago
Standard dosing could fail to achieve adequate systemic concentrations in ICU children or may lead to toxicity in children with acute kidney injury. The population pharmacokinetic analysis was used to simultaneously analyze all available data (plasma, prefilter, postfilter, effluent, and urine concentrations) and provide the pharmacokinetic characteristics of meropenem. The probability of target fT > MIC attainment, avoiding toxic levels, during the entire dosing interval was estimated by simulation of different intermittent and continuous infusions in the studied population...
April 24, 2024: Antimicrobial Agents and Chemotherapy
#31
JOURNAL ARTICLE
Qian Tong, Chengqiang Yin, Xudong Hang, Yuefan Bai, Chongwen Zhang, Jingcheng Xu, Yan Huang, Yixin Ge, Tianyu Chen, Liping Zeng, Jia Jia, Hongkai Bi
Currently, Helicobacter pylori eradication by antibiotic therapy faces various challenges, including antibiotic resistance, side effects on intestinal commensal bacteria, and patient compliance. In this study, loureirin A (LrA), a traditional Chinese medicine monomer extracted from Sanguis Draconis flavones, was found to possess specific antibacterial activity against H. pylori without the bacteria displaying a tendency to develop resistance in vitro . LrA demonstrated a synergistic or additive effect when combined with omeprazole (a proton pump inhibitor) against H...
April 24, 2024: Antimicrobial Agents and Chemotherapy
#32
JOURNAL ARTICLE
Sofia Asioli, Federica Guaraldi, Matteo Zoli, Diego Mazzatenta, Chiara Villa
Pituitary tumors present heterogeneous biochemical, clinico-radiological, and histological features. Although histologically benign, a non-negligible number of cases present an unpredictable aggressive behavior with local invasiveness, partial/complete resistance to treatment and/or recurrence after surgery, and, rarely, metastasize, overall leading to a significant increase of morbidity, and, thus, requiring skilled multidisciplinary management in referral Centers. Histopathological diagnosis is essential to stratify cancer patient risk and uniform follow-up among Centers...
April 24, 2024: Minerva endocrinology
#33
JOURNAL ARTICLE
Eleftheria Antoniadou, Emanuele Giusti, Paolo Capodaglio, Der-Sheng Han, Francesca Gimigliano, Juan M Guzman, Mooyeon Oh-Park, Walter Frontera
INTRODUCTION: Aging is associated with an increased burden of multi-morbidity and disease related functional loss and disability, widely impacting patients and health care systems. Frailty is a major actor in age-related disability and is an important target for rehabilitation interventions, considering that is a reversible condition. EVIDENCE ACQUISITION: A working group of members of the ISPRM, responding to WHO 2030 call for action to strengthen rehabilitation, was established to assess the quality and implementability of the existing guidelines for the rehabilitation of frailty...
April 24, 2024: European Journal of Physical and Rehabilitation Medicine
#34
RANDOMIZED CONTROLLED TRIAL
Anjishnujit Bandyopadhyay, Lakshmi Narayana Yaddanapudi, Vikas Saini, Neeru Sahni, Sandeep Grover, Sunaakshi Puri, Vighnesh Ashok
OBJECTIVE: To determine whether enteral melatonin decreases the incidence of delirium in critically ill adults. METHODS: In this randomized controlled trial, adults were admitted to the intensive care unit and received either usual standard care alone (Control Group) or in combination with 3mg of enteral melatonin once a day at 9 PM (Melatonin Group). Concealment of allocation was done by serially numbered opaque sealed envelopes. The intensivist assessing delirium and the investigator performing the data analysis were blinded to the group allocation...
2024: Crit Care Sci
#35
REVIEW
E M S Martins, L C Nascimento da Silva, M S Carmo
Acute diarrhea is the second leading cause of morbidity and mortality attributed to infections in children under five years of age worldwide, with 1.7 million annual estimated cases and more than 500,000 deaths. Although hydroelectrolytic replacement is the gold standard in treating diarrhea, it does not interfere with the restoration of the intestinal microbiota. Several studies have searched for an adequate alternative in restructuring intestinal homeostasis, finding that treatments based on probiotics, prebiotics, and synbiotics are effective, which made such treatments increasingly present in clinical practice by reducing illness duration with minimal side effects...
2024: Brazilian Journal of Medical and Biological Research
#36
JOURNAL ARTICLE
Luci Meire P Silva, Tiago Eugênio Faria E Arantes, Aristófanes Canamary, Yuslay Fernández Zamora, Luciana Peixoto S Finamor, Ester Abigail Martins, Ricardo Pedro Casaroli-Marano, Cristina Muccioli
PURPOSE: To assess the quality of life in patients diagnosed as having tuberculous uveitis and its association with sociodemographic, clinical, and psychosocial aspects. METHOD: By conducting standardized interviews, clinical and demographic data were collected using a measure developed in this study. This measure was applied in addition to other measures, namely SF-12, Hospital Anxiety and Depression Scale, and NEI-VFQ-39, which were used to assess health-related quality of life, anxiety and depression symptoms, and visual functioning...
2024: Arquivos Brasileiros de Oftalmologia
#37
JOURNAL ARTICLE
Allexya Affonso Antunes Marcos, Denise Freitas, Jeison de Nadai Barros, Arthur Gustavo Fernandes, Márcia Lowen, Moacyr Rigueiro, Melina Correia Morales, Rubens Belfort Neto, Arun D Singh
PURPOSE: To describe cellular alterations detected by impression cytology of the ocular surface in patients with xeroderma pigmentosum. The secondary objective was to assess the reliability of impression cytology in diagnosing ocular surface squamous neoplasia. METHODS: Patients with xeroderma pigmentosum underwent a single-day complete ophthalmological examination and impression cytology for ocular surface evaluation using 13 mm diameter mixed cellulose esters membrane filters and combined staining with Periodic Acid Schiff, Hematoxylin and Eosin, and Papanicolaou stains followed by microscopic analysis...
2024: Arquivos Brasileiros de Oftalmologia
#38
RANDOMIZED CONTROLLED TRIAL
Nurullah İshak Işık, Ayhan Özhasenekler, Çağdaş Yıldırım, Alp Şener, Fatih Ahmet Kahraman, Gül Pamukçu Günaydın
OBJECTIVE: In our study, we aimed to compare the effect of standard rapid sequence intubation protocol and the application of rocuronium priming technique on the procedure time and hemodynamic profile. METHODS: Patients who applied to the emergency department and needed rapid sequence intubation were included in our study, which we conducted with a randomized controlled design. Randomization in the study was made according to the order of arrival of the cases. Rapid sequence intubation was performed in the standard group...
2024: Revista da Associação Médica Brasileira
#39
RANDOMIZED CONTROLLED TRIAL
Rodrigo Caetano de Souza, Lilianne Louise Silva de Morais, Mario Claudio Ghefter, Juliana Pereira Franceschini, Fernando Campos Gomes Pinto
BACKGROUND: There is still a debate regarding the most appropriate pleural collector model to ensure a short hospital stay and minimum complications. OBJECTIVES: To study aimed to compare the time of air leak, time to drain removal, and length of hospital stay between a standard water-seal drainage system and a pleural collector system with a unidirectional flutter valve and rigid chamber. DESIGN AND SETTING: A randomized prospective clinical trial was conducted at a high-complexity hospital in São Paulo, Brazil...
2024: São Paulo Medical Journal
#40
JOURNAL ARTICLE
Hannah Elizabeth Bartley, Emma Kate Lefroy Turner, Timothy John Ford, Sarah Cherian
AIM: To describe the characteristics of patients with chronic hepatitis B (CHB) presenting to a tertiary paediatric hospital in Perth, Western Australia. Review of implementation of previous follow-up recommendations for the cohort was also undertaken. METHOD: A retrospective data analysis of all individuals aged between 0 and 17 years presenting to the tertiary children's hospital who were hepatitis B surface antigen (HBsAg) positive over 8 years (2013-2020)...
April 24, 2024: Journal of Paediatrics and Child Health
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