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simulation and health

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https://www.readbyqxmd.com/read/27909393/a-comparison-of-multiple-behavior-models-in-a-simulation-of-the-aftermath-of-an-improvised-nuclear-detonation
#1
Nidhi Parikh, Harshal G Hayatnagarkar, Richard J Beckman, Madhav V Marathe, Samarth Swarup
We describe a large-scale simulation of the aftermath of a hypothetical 10kT improvised nuclear detonation at ground level, near the White House in Washington DC. We take a synthetic information approach, where multiple data sets are combined to construct a synthesized representation of the population of the region with accurate demographics, as well as four infrastructures: transportation, healthcare, communication, and power. In this article, we focus on the model of agents and their behavior, which is represented using the options framework...
November 2016: Autonomous Agents and Multi-agent Systems
https://www.readbyqxmd.com/read/27909309/hydrogen-sulfide-h2s-emission-control-by-aerobic-sulfate-reduction-in-landfill
#2
Yuyang Long, Yuan Fang, Dongsheng Shen, Huajun Feng, Ting Chen
H2S emissions from landfill sites resulting from sulfate reduction has become a serious human health and ecological safety issue. This study investigated H2S emission behavior and sulfate metabolism occurring in simulated landfills under different operating conditions. Under aerobic conditions, great attenuation of the original sulfate content (from around 6000 mg kg(-1) dropped to below 800 mg kg(-1)) with corresponding accumulation of sulfides and elemental sulfur were observed, indicating that sulfate reduction processes were intense under such conditions...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27905942/a-novel-method-for-estimating-distributions-of-body-mass-index
#3
Marie Ng, Patrick Liu, Blake Thomson, Christopher J L Murray
BACKGROUND: Understanding trends in the distribution of body mass index (BMI) is a critical aspect of monitoring the global overweight and obesity epidemic. Conventional population health metrics often only focus on estimating and reporting the mean BMI and the prevalence of overweight and obesity, which do not fully characterize the distribution of BMI. In this study, we propose a novel method which allows for the estimation of the entire distribution. METHODS: The proposed method utilizes the optimization algorithm, L-BFGS-B, to derive the distribution of BMI from three commonly available population health statistics: mean BMI, prevalence of overweight, and prevalence of obesity...
March 12, 2016: Population Health Metrics
https://www.readbyqxmd.com/read/27905895/mortality-along-the-continuum-of-hiv-care-in-rwanda-a-model-based-analysis
#4
Eran Bendavid, David Stauffer, Eric Remera, Sabin Nsanzimana, Steve Kanters, Edward J Mills
BACKGROUND: HIV is the leading cause of death among adults in sub-Saharan Africa. However, mortality along the HIV care continuum is poorly described. We combine demographic, epidemiologic, and health services data to estimate where are people with HIV dying along Rwanda's care continuum. METHODS: We calibrated an age-structured HIV disease and transmission stochastic simulation model to the epidemic in Rwanda. We estimate mortality among HIV-infected individuals in the following states: untested, tested without establishing care in an antiretroviral therapy (ART) program (unlinked), in care before initiating ART (pre-ART), lost to follow-up (LTFU) following ART initiation, and retained in active ART care...
December 1, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27903191/cost-effectiveness-of-stereotactic-radiosurgery-versus-whole-brain-radiation-therapy-for-up-to-10-brain-metastases
#5
Nataniel H Lester-Coll, Arie P Dosoretz, William J Magnuson, Maxwell S Laurans, Veronica L Chiang, James B Yu
OBJECTIVE The JLGK0901 study found that stereotactic radiosurgery (SRS) is a safe and effective treatment option for treating up to 10 brain metastases. The purpose of this study is to determine the cost-effectiveness of treating up to 10 brain metastases with SRS, whole-brain radiation therapy (WBRT), or SRS and immediate WBRT (SRS+WBRT). METHODS A Markov model was developed to evaluate the cost effectiveness of SRS, WBRT, and SRS+WBRT in patients with 1 or 2-10 brain metastases. Transition probabilities were derived from the JLGK0901 study and modified according to the recurrence rates observed in the Radiation Therapy Oncology Group (RTOG) 9508 and European Organization for Research and Treatment of Cancer (EORTC) 22952-26001 studies to simulate the outcomes for patients who receive WBRT...
December 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27902949/use-of-simulation-based-learning-in-undergraduate-nurse-education-an-umbrella-systematic-review
#6
REVIEW
Robyn P Cant, Simon J Cooper
OBJECTIVE: To conduct a systematic review to appraise and review evidence on the impact of simulation-based education for undergraduate/pre-licensure nursing students, using existing reviews of literature. DESIGN: An umbrella review (review of reviews). DATA SOURCES: Cumulative Index of Nursing and Allied Health Literature (CINAHLPlus), PubMed, and Google Scholar. STUDY SELECTION: Reviews of literature conducted between 2010 and 2015 regarding simulation-based education for pre-licensure nursing students...
November 22, 2016: Nurse Education Today
https://www.readbyqxmd.com/read/27902693/the-long-term-benefits-of-increased-aspirin-use-by-at-risk-americans-aged-50-and-older
#7
David B Agus, Étienne Gaudette, Dana P Goldman, Andrew Messali
BACKGROUND: The usefulness of aspirin to defend against cardiovascular disease in both primary and secondary settings is well recognized by the medical profession. Multiple studies also have found that daily aspirin significantly reduces cancer incidence and mortality. Despite these proven health benefits, aspirin use remains low among populations targeted by cardiovascular prevention guidelines. This article seeks to determine the long-term economic and population-health impact of broader use of aspirin by older Americans at higher risk for cardiovascular disease...
2016: PloS One
https://www.readbyqxmd.com/read/27902533/using-simulation-in-global-health-considerations-for-design-and-implementation
#8
Michael B Pitt, Walter J Eppich, Margaret L Shane, Sabrina M Butteris
Providers and educators increasingly participate in global health work during their careers. Simulation can play an important role in both preparing learners for work in resource-limited settings and training providers in these countries. However, little guidance exists for educators interested in creating and implementing scenarios for these settings. We discuss several key considerations unique to global health simulation ranging from addressing common cultural differences surrounding healthcare and varied regional approaches to disease identification and management to understanding precisely what resources exist in the setting and what strategies can be used to provide care when the expected resources are not available...
November 29, 2016: Simulation in Healthcare: Journal of the Society for Simulation in Healthcare
https://www.readbyqxmd.com/read/27901083/resveratrol-serves-as-a-protein-substrate-interaction-stabilizer-in-human-sirt1-activation
#9
Xuben Hou, David Rooklin, Hao Fang, Yingkai Zhang
Resveratrol is a natural compound found in red wine that has been suggested to exert its potential health benefit through the activation of SIRT1, a crucial member of the mammalian NAD(+)-dependent deacetylases. SIRT1 has emerged as an attractive therapeutic target for many aging related diseases, however, how its activity can only be activated toward some specific substrates by resveratrol has been poorly understood. Herein, by employing extensive molecular dynamics simulations as well as fragment-centric topographical mapping of binding interfaces, we have clarified current controversies in the literature and elucidated that resveratrol plays an important activation role by stabilizing SIRT1/peptide interactions in a substrate-specific manner...
November 30, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27899904/theory-based-interventions-combining-mental-simulation-and-planning-techniques-to-improve-physical-activity-null-results-from-two-randomized-controlled-trials
#10
Carine Meslot, Aurélie Gauchet, Benoît Allenet, Olivier François, Martin S Hagger
Interventions to assist individuals in initiating and maintaining regular participation in physical activity are not always effective. Psychological and behavioral theories advocate the importance of both motivation and volition in interventions to change health behavior. Interventions adopting self-regulation strategies that foster motivational and volitional components may, therefore, have utility in promoting regular physical activity participation. We tested the efficacy of an intervention adopting motivational (mental simulation) and volitional (implementation intentions) components to promote a regular physical activity in two studies...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27899835/use-of-an-online-game-to-evaluate-health-professions-students-attitudes-toward-people-in-poverty
#11
Carriann E Richey Smith, Priscilla Ryder, Ann Bilodeau, Michele Schultz
Objective. To determine baseline attitudes of pharmacy, physician assistant studies, and communication science and disorders students toward people in poverty and to examine the effectiveness of using the online poverty simulation game SPENT to affect these attitudes. Methods. Students completed pre/postassessments using the validated Undergraduate Perceptions of Poverty Tracking Survey (UPPTS). Students played the online, open access, SPENT game alone and/or in pairs in a 50-minute class. Results. Significant improvements in scale scores were seen in students after playing SPENT...
October 25, 2016: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/27899834/evaluation-of-interprofessional-team-disclosure-of-a-medical-error-to-a-simulated-patient
#12
Kelly R Ragucci, Donna H Kern, Sarah P Shrader
Objective. To evaluate the impact of an Interprofessional Communication Skills Workshop on pharmacy student confidence and proficiency in disclosing medical errors to patients. Pharmacy student behavior was also compared to that of other health professions' students on the team. Design. Students from up to four different health professions participated in a simulation as part of an interprofessional team. Teams were evaluated with a validated rubric postsimulation on how well they handled the disclosure of an error to the patient...
October 25, 2016: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/27898787/zeolite-combined-with-alum-and-polyaluminum-chloride-mixed-with-agricultural-slurries-reduces-carbon-losses-in-runoff-from-grassed-soil-boxes
#13
J G Murnane, R B Brennan, O Fenton, M G Healy
Carbon (C) losses from agricultural soils to surface waters can migrate through water treatment plants and result in the formation of disinfection by-products, which are potentially harmful to human health. This study aimed to quantify total organic carbon (TOC) and total inorganic C losses in runoff after application of dairy slurry, pig slurry, or milk house wash water (MWW) to land and to mitigate these losses through coamendment of the slurries with zeolite (2.36-3.35 mm clinoptilolite) and liquid polyaluminum chloride (PAC) (10% AlO) for dairy and pig slurries or liquid aluminum sulfate (alum) (8% AlO) for MWW...
November 2016: Journal of Environmental Quality
https://www.readbyqxmd.com/read/27898668/the-long-term-safety-public-health-impact-and-cost-effectiveness-of-routine-vaccination-with-a-recombinant-live-attenuated-dengue-vaccine-dengvaxia-a-model-comparison-study
#14
Stefan Flasche, Mark Jit, Isabel Rodríguez-Barraquer, Laurent Coudeville, Mario Recker, Katia Koelle, George Milne, Thomas J Hladish, T Alex Perkins, Derek A T Cummings, Ilaria Dorigatti, Daniel J Laydon, Guido España, Joel Kelso, Ira Longini, Jose Lourenco, Carl A B Pearson, Robert C Reiner, Luis Mier-Y-Terán-Romero, Kirsten Vannice, Neil Ferguson
BACKGROUND: Large Phase III trials across Asia and Latin America have recently demonstrated the efficacy of a recombinant, live-attenuated dengue vaccine (Dengvaxia) over the first 25 mo following vaccination. Subsequent data collected in the longer-term follow-up phase, however, have raised concerns about a potential increase in hospitalization risk of subsequent dengue infections, in particular among young, dengue-naïve vaccinees. We here report predictions from eight independent modelling groups on the long-term safety, public health impact, and cost-effectiveness of routine vaccination with Dengvaxia in a range of transmission settings, as characterised by seroprevalence levels among 9-y-olds (SP9)...
November 2016: PLoS Medicine
https://www.readbyqxmd.com/read/27898627/publishing-trends-in-the-field-of-pediatric-emergency-medicine-from-2004-to-2013
#15
Nancy S Rixe, Jeffrey Rixe, Joshua Glick, Erik Lehman, Robert P Olympia
OBJECTIVE: To identify publishing trends within the field of pediatric emergency medicine between 2004 and 2013. METHODS: We conducted a MEDLINE search of pediatric emergency medicine articles, filtered by clinical trial, published between 2004 and 2013 in ten journals from the fields of pediatrics, emergency medicine, general medicine, and pediatric emergency medicine. Each article was classified by journal type, study design, results (positive or negative/equivocal), age/type of subjects, and major topic (based on the objective of the study)...
December 2016: Pediatric Emergency Care
https://www.readbyqxmd.com/read/27896984/methods-for-clustering-time-series-data-acquired-from-mobile-health-apps
#16
Nicole Tignor, Pei Wang, Nicholas Genes, Linda Rogers, Steven G Hershman, Erick R Scott, Micol Zweig, Yu-Feng Yvonne Chan, Eric E Schadt
In our recent Asthma Mobile Health Study (AMHS), thousands of asthma patients across the country contributed medical data through the iPhone Asthma Health App on a daily basis for an extended period of time. The collected data included daily self-reported asthma symptoms, symptom triggers, and real time geographic location information. The AMHS is just one of many studies occurring in the context of now many thousands of mobile health apps aimed at improving wellness and better managing chronic disease conditions, leveraging the passive and active collection of data from mobile, handheld smart devices...
2016: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/27896976/missing-data-imputation-in-the-electronic-health-record-using-deeply-learned-autoencoders
#17
Brett K Beaulieu-Jones, Jason H Moore
Electronic health records (EHRs) have become a vital source of patient outcome data but the widespread prevalence of missing data presents a major challenge. Different causes of missing data in the EHR data may introduce unintentional bias. Here, we compare the effectiveness of popular multiple imputation strategies with a deeply learned autoencoder using the Pooled Resource Open-Access ALS Clinical Trials Database (PRO-ACT). To evaluate performance, we examined imputation accuracy for known values simulated to be either missing completely at random or missing not at random...
2016: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/27894805/leaching-behavior-of-veterinary-antibiotics-in-animal-manure-applied-soils
#18
Min Pan, L M Chu
Agricultural fields worldwide are being contaminated by the escalating application of veterinary antibiotics (VAs) via animal manure and biosolids applied as fertilizers or of wastewater for irrigation, resulting in soil degradation and damage to the health of terrestrial environments. This paper describes a series of column studies investigating the leaching behavior of five VAs, tetracycline (TC), sulfamethazine (SMZ), norfloxacin (NOR), erythromycin (ERY) and chloramphenicol (CAP), under different simulated rainfall conditions that could occur in agricultural environments...
November 25, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27894323/health-related-quality-of-life-and-a-cost-utility-simulation-of-adults-in-the-uk-with-osteogenesis-imperfecta-x-linked-hypophosphatemia-and-fibrous-dysplasia
#19
Lydia Forestier-Zhang, Laura Watts, Alison Turner, Harriet Teare, Jane Kaye, Joe Barrett, Cyrus Cooper, Richard Eastell, Paul Wordsworth, Muhammad K Javaid, Rafael Pinedo-Villanueva
BACKGROUND: Health-related quality of life of adults with osteogenesis imperfecta (OI), fibrous dysplasia (FD) and X-linked hypophosphatemia (XLH) remains poorly described. The aim of this study was to describe the HRQoL of adults with osteogenesis imperfecta, fibrous dysplasia and X-linked hypophophataemia and perform a cost-utility simulation to calculate the maximum cost that a health care system would be willing to pay for a hypothetical treatment of a rare bone disease. RESULTS: Participants completed the EQ-5D-5 L questionnaire between September 2014 and March 2016...
November 28, 2016: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/27893864/cost-effectiveness-of-the-one4all-hiv-linkage-intervention-in-guangxi-zhuang-autonomous-region-china
#20
Xiao Zang, Houlin Tang, Jeong Eun Min, Diane Gu, Julio S G Montaner, Zunyou Wu, Bohdan Nosyk
BACKGROUND: In Guangxi Zhuang Autonomous Region, China, an estimated 80% of newly-identified antiretroviral therapy (ART)-eligible patients are not engaged in ART. Delayed ART uptake ultimately translates into high rates of HIV morbidity, mortality, and transmission. To enhance HIV testing receipt and subsequent treatment uptake in Guangxi, the Chinese Center for Disease Control and Prevention (CDC) executed a cluster-randomized trial to assess the effectiveness and cost-effectiveness of a streamlined HIV testing algorithm (the One4All intervention) in 12 county-level hospitals...
2016: PloS One
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