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https://www.readbyqxmd.com/read/29143719/microbial-protein-targets-towards-understanding-and-intervention
#1
Paul W Denny
The rise of antimicrobial resistance, coupled with a lack of industrial focus on antimicrobial discovery over preceding decades, has brought the world to a crisis point. With both human and animal health set to decline due to increased disease burdens caused by near untreatable microbial pathogens, there is an urgent need to identify new antimicrobials. Central to this is the elucidation of new, robustly validated, drug targets. Informed by industrial practice and concerns, the use of both biological and chemical tools in validation is key...
November 16, 2017: Parasitology
https://www.readbyqxmd.com/read/29143666/comparative-evaluation-of-commercially-available-point-of-care-heartworm-antigen-tests-using-well-characterized-canine-plasma-samples
#2
Lindsay A Starkey, Joy V Bowles, Mark E Payton, Byron L Blagburn
BACKGROUND: Dirofilaria immitis is a worldwide parasite that is endemic in many parts of the United States. There are many commercial assays available for the detection of D. immitis antigen, one of which was modified and has reentered the market. Our objective was to compare the recently reintroduced Witness® Heartworm (HW) Antigen test Kit (Zoetis, Florham Park, NJ) and the SNAP® Heartworm RT (IDEXX Laboratories, Inc., Westbrook, ME) to the well-based ELISA DiroChek® Heartworm Antigen Test Kit (Zoetis, Florham Park, NJ)...
November 9, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29141762/efficacy-of-artemether-lumefantrine-for-uncomplicated-plasmodium-falciparum-malaria-in-cruzeiro-do-sul-brazil-2016
#3
Megumi Itoh, Suiane Negreiros do Valle, Sâmela Farias, Thayna Maria Holanda de Souza, Giselle Maria Rachid Viana, Naomi Lucchi, Stella Chenet, Paola Marchesini, Marinete Póvoa, Ana Carolina Faria E Silva Santelli, Alexandre Macedo de Oliveira
We evaluated the therapeutic efficacy of artemether-lumefantrine (AL) fixed-dose combination to treat uncomplicated Plasmodium falciparum malaria in Cruzeiro do Sul, Acre State, in the Amazon region of Brazil. Between December 2015 and May 2016, we enrolled 79 patients, 5-79 years old with fever or history of fever in the previous 48 hours and P. falciparum monoinfection confirmed by microscopy. Attempts were made to provide direct observation or phone reminders for all six doses of AL, and patients were followed-up for 28 days...
November 6, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29140309/biosensors-to-diagnose-chagas-disease-a-brief-review
#4
REVIEW
María-Isabel Rocha-Gaso, Luis-Jesús Villarreal-Gómez, Denis Beyssen, Frédéric Sarry, Marco-Antonio Reyna, Carlos-Napoleón Ibarra-Cerdeña
Chagas disease (CD), which mostly affects those living in deprived areas, has become one of Latin America's main public health problems. Effective prevention of the disease requires early diagnosis, initiation of therapy, and regular blood monitoring of the infected individual. However, the majority of the Trypanosoma cruzi infections go undiagnosed because of mild symptoms, limited access to medical attention and to a high variability in the sensitivity and specificity of diagnostic tests. Consequently, more affordable and accessible detection technologies capable of providing early diagnosis and T...
November 15, 2017: Sensors
https://www.readbyqxmd.com/read/29135400/-the-comparison-of-microscopy-and-real-time-polymerase-chain-reaction-methods-for-the-diagnosis-of-pneumocystis-jirovecii-pneumonia-evaluation-of-clinical-parameters
#5
Seray Töz, Cumhur Gündüz, Aslı Tetik, Meltem Taşbakan, Hüsnü Pullukçu, Feza Bacakoğlu, Mehmet Sezai Taşbakan, Figen Gülen, Ayşegül Ünver, Nevin Turgay
Introduction: Pneumocystis jirovecii pneumonia (PCP) causes serious infections, especially in patients with immunosuppressive diseases. In this study, it was aimed to evaluate the results of samples obtained from PCP suspected patients using two different methods together with clinical data. Materials and Methods: Microscopy and real time polymerase chain reaction (real time PCR) methods were performed with bronchoalveolar lavage (BAL) samples sended to Ege University Medical Faculty Direct Parasitology Diagnostic Laboratory between March 2009 and June 2010...
September 2017: Tüberküloz Ve Toraks
https://www.readbyqxmd.com/read/29132792/-neuromeningeal-cryptococcosis-in-patients-infected-with-hiv-at-agadir-regional-hospital-souss-massa-morocco
#6
S Chadli, M Aghrouch, N Taqarort, M Malmoussi, Z Ouagari, F Moustaoui, M Bourouache, S Oulkheir
INTRODUCTION: Neuromeningeal cryptococcosis (NMC) is a severe and fatal opportunistic infection. Lethality is frequent in the absence of treatment, especially in the presence of HIV co-infection. OBJECTIVE: To determine the prevalence, epidemiological, clinical, biological and therapeutic aspects as well as the evolution of NMC for patients infected with HIV. PATIENTS AND METHODS: This is a retrospective study of 40 cases of neuromeningeal cryptococcosis diagnosed in HIV-infected patients...
November 10, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/29128241/-diagnosis-and-treatment-of-scabies-by-general-practitioners-a-survey-of-practices-in-france
#7
A R Schmidt-Guerre, B Aranda-Hulin, M Maumy-Bertrand, F Aubin
BACKGROUND: Although there is evidence suggesting an epidemiologic increase of scabies in France, few studies have assessed medical practice in terms of diagnosis and treatment. OBJECTIVES: To describe the management of scabies by general practitioners (GPs). PATIENTS AND METHODS: A questionnaire was addressed to the 524 GPs of the Doubs department in France regarding the management of cases of scabies diagnosed between January and June 2015...
November 8, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29126122/mode-and-rate-of-evolution-of-haemosporidian-mitochondrial-genomes-timing-the-radiation-of-avian-parasites
#8
M Andreína Pacheco, Nubia E Matta, Gediminas Valkiunas, Patricia G Parker, Beatriz Mello, Craig E Stanley, Miguel Lentino, M Alexandra Garcia-Amado, Michael Cranfield, Sergei L Kosakovsky Pond, Ananias A Escalante
Haemosporidians are a diverse group of vector-borne parasitic protozoa that includes the agents of human malaria; however, most of the described species are found in birds and reptiles. Although our understanding of these parasites' diversity has expanded by analyses of their mitochondrial genes, there is limited information on these genes' evolutionary rates. Here, 114 mitochondrial genomes (mtDNA) were studied from species belonging to four genera: Leucocytozoon, Haemoproteus, Hepatocystis, and Plasmodium...
November 6, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/29122387/protection-against-schistosoma-haematobium-infection-in-hamsters-by-immunization-with-schistosoma-mansoni-gut-derived-cysteine-peptidases-smcb1-and-smcl3
#9
Hatem Tallima, Marwa Abou El Dahab, Sahira Kareem, John Pius Dalton, Rashika El Ridi
We examined the immunogenicity and protective potential of SmCB1 and SmCL3 cysteine peptidases, alone and in combination, in hamsters challenged with S. haematobium. For each of two independent experiments, eight Syrian hamsters were immunized twice with a three week-interval with 0 (controls), 20 µg SmCB1, 20 µg SmCL3, or 10 µg SmCB1 plus 10 µg SmCL3, and then percutaneously exposed eight weeks later to 100 S. haematobium cercariae. Hamsters from each group were assessed for humoral and whole blood culture cytokine responses on day 10 post challenge infection, and examined for parasitological parameters 12 weeks post infection...
November 6, 2017: Vaccine
https://www.readbyqxmd.com/read/29118011/comparative-genome-analysis-of-programmed-dna-elimination-in-nematodes
#10
Jianbin Wang, Shenghan Gao, Yulia Mostovoy, Yuanyuan Kang, Maxim Zagoskin, Yongqiao Sun, Bing Zhang, Laura K White, Alice Easton, Thomas B Nutman, Pui-Yan Kwok, Songnian Hu, Martin K Nielsen, Richard E Davis
Programmed DNA elimination is a developmentally regulated process leading to the reproducible loss of specific genomic sequences. DNA elimination occurs in unicellular ciliates and a variety of metazoans, including invertebrates and vertebrates. In metazoa, DNA elimination typically occurs in somatic cells during early development, leaving the germline genome intact. Reference genomes for metazoa that undergo DNA elimination are not available. Here, we generated germline and somatic reference genome sequences of the DNA eliminating pig parasitic nematode Ascaris suum and the horse parasite Parascaris univalens...
November 8, 2017: Genome Research
https://www.readbyqxmd.com/read/29117879/human-parasitology-worldwide-research
#11
Jose Antonio Garrido-Cardenas, Concepción Mesa-Valle, Francisco Manzano-Agugliaro
In this article, the trends in human parasitology have been studied through the analysis of the number of publications in this area. The parameters studied were: number of articles, language, countries and institutions with the highest number of publications, and keywords with greater presence in the articles of human parasitology. The results of the analysis confirm the growing interest in this area, observing an exponential growth in the number of publications in the last decades. We also verified that the main country in terms of scientific production is the USA, although among the most important institutions, we find non-US centres such as the Oswaldo Cruz Foundation and the London School of Hygiene and Tropical Medicine...
November 9, 2017: Parasitology
https://www.readbyqxmd.com/read/29114496/calendar-of-upcoming-events-in-parasitology-2017
#12
(no author information available yet)
No abstract text is available yet for this article.
July 2017: Tropical Parasitology
https://www.readbyqxmd.com/read/29114487/prevalence-of-trypanosome-infection-in-tsetse-flies-from-oji-river-and-emene-axis-of-enugu-state-nigeria-a-preliminary-report
#13
Kenechukwu Chibuike Onyekwelu, Fidelis Ebele Ejezie, Anthonius Anayochukwu Eze, Joy Ebele Ikekpeazu, Richard Chukwunonye Ezeh, Godknows Chizurumoke Edeh
Introduction: Trypanosomes are protozoan parasites of vertebrates transmitted by blood-sucking tsetse fly. Trypanosomes remain a constant threat to the lives of humans and animals throughout large regions of Africa. Aims and Objectives: This study investigated the presence, prevalence, and species of trypanosome parasite in tsetse flies caught in two areas of no previous documented history of trypanosome infection. Materials and Methods: For this purpose, 63 and 77 nonterenal tsetse flies were collected from Oji River and Emene areas of Enugu State Nigeria, respectively...
July 2017: Tropical Parasitology
https://www.readbyqxmd.com/read/29114142/gastrointestinal-parasitic-infections-in-indian-gaddi-goat-breed-bucks-clinical-hemato-biochemical-parasitological-and-chemotherapeutic-studies
#14
Aman Dev Moudgil, Ankur Sharma, Madan Singh Verma, Ravindra Kumar, Pradeep Kumar Dogra, Pallavi Moudgil
The present study was envisaged with an aim to evaluate gastrointestinal parasitic infections in a herd of conserved Gaddi (goat) breed bucks (6-9 months of age) kept on semi-intensive feeding management. The individuals (n = 20) representing the herd were selected and divided into two groups; group I (n = 10), clinically ill and group II (n = 10), sub clinically infected individuals. The clinical examination revealed anemia, emaciation and rise in body temperature of the individuals of group I as compared to group II...
December 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/29114141/effect-of-phenyl-vinyl-sulphone-cysteine-protease-inhibitor-on-schistosoma-mansoni-in-vitro-and-in-vivo-experimental-studies
#15
Manal Salah El-Din Mahmoud, Ayman Nabil Ibrahim, Abeer Fathy Badawy, Nourhan Mohamed Abdelmoniem
The present work aimed to study the effect of phenyl vinyl sulphone (PVS), a CPI, on different stages of Schistosoma (S.) mansoni in an in vitro culture study and in experimentally infected mice, compared to PZQ. As regards the in vitro study, different concentrations of PVS (1, 2, 4, 6, 8 and 10 µg/ml) and PZQ (1 µg/ml) were assessed by % worm mortality for schistosomula and adults, and hemoglobin degradation by schistosomula. In vivo study included 8 groups of mice. Intraperitoneal PVS, subgroup (a), and oral PZQ, subgroup (b), were assessed at different durations post infection (pi); at 1, 3, 5 and 7 weeks pi (groups I, II, III and IV, respectively)...
December 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/29114123/occurrence-of-two-new-species-of-the-genus-dipartiella-raabe-1959-stein-1961-ciliophora-trichodinidae-isolated-for-the-first-time-from-ornamental-fish
#16
Mandira Saha, P K Bandyopadhyay
During the parasitological survey of ornamental fish in India the authors identified two trichodinid ciliophorans for the first time in India, during the year 2014-16 and also revealed that goldfish, Carassius auratus, was the most susceptible species for trichodinid infection. Two ciliophorans have been isolated and identified on the basis of wet silver nitrate impregnation technique followed by taxonomic description, morphometric variability and comparative data with its closely related species. Considering all the important features including diameter, structure of denticles, rays and ciliatures the authors are of the opinion that the identified species are new to science...
December 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/29114120/free-living-amoebae-in-the-water-resources-of-iran-a-systematic-review
#17
REVIEW
Ehsan Saburi, Toktam Rajaii, Asma Behdari, Mohammad Hasan Kohansal, Hossein Vazini
Free-living amoebae (FLA) are a group of protozoa with the capabilities of growth in the environment and invasion to the human body which have been isolated from different water sources. Acanthamoeba, Naegleria, and Balamuthia are the most important FLA. These cause a variety of severe complications of eye and central nervous system. Despite the fact that various studies have demonstrated the prevalence of FLA in different parts of Iran, there is no comprehensive evaluation and conclusion regarding the pollution of various water sources in Iran...
December 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/29113696/embracing-colonizations-a-new-paradigm-for-species-association-dynamics
#18
REVIEW
Sören Nylin, Salvatore Agosta, Staffan Bensch, Walter A Boeger, Mariana P Braga, Daniel R Brooks, Matthew L Forister, Peter A Hambäck, Eric P Hoberg, Tommi Nyman, Alexander Schäpers, Alycia L Stigall, Christopher W Wheat, Martin Österling, Niklas Janz
Parasite-host and insect-plant research have divergent traditions despite the fact that most phytophagous insects live parasitically on their host plants. In parasitology it is a traditional assumption that parasites are typically highly specialized; cospeciation between parasites and hosts is a frequently expressed default expectation. Insect-plant theory has been more concerned with host shifts than with cospeciation, and more with hierarchies among hosts than with extreme specialization. We suggest that the divergent assumptions in the respective fields have hidden a fundamental similarity with an important role for potential as well as actual hosts, and hence for host colonizations via ecological fitting...
November 4, 2017: Trends in Ecology & Evolution
https://www.readbyqxmd.com/read/29108026/status-of-soil-transmitted-helminth-infections-in-schoolchildren-in-laguna-province-the-philippines-determined-by-parasitological-and-molecular-diagnostic-techniques
#19
Mary Lorraine S Mationg, Catherine A Gordon, Veronica L Tallo, Remigio M Olveda, Portia P Alday, Mark Donald C Reñosa, Franziska A Bieri, Gail M Williams, Archie C A Clements, Peter Steinmann, Kate Halton, Yuesheng Li, Donald P McManus, Darren J Gray
BACKGROUND: Soil-transmitted helminths (STH) are the most common parasitic infections in impoverished communities, particularly among children. Current STH control is through school-based mass drug administration (MDA), which in the Philippines is done twice annually. As expected, MDA has decreased the intensity and prevalence of STH over time. As a result, the common Kato Katz (KK) thick smear method of detecting STH is less effective because it lacks sensitivity in low intensity infections, making it difficult to measure the impact of deworming programs...
November 6, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29103267/intestinal-parasitic-infections-and-environmental-water-contamination-in-a-rural-village-of-northern-lao-pdr
#20
Alexis Ribas, Chloé Jollivet, Serge Morand, Boupha Thongmalayvong, Silaphet Somphavong, Chern-Chiang Siew, Pei-Jun Ting, Saipin Suputtamongkol, Viengsaene Saensombath, Surapol Sanguankiat, Boon-Huan Tan, Phimpha Paboriboune, Kongsap Akkhavong, Kittipong Chaisiri
A field survey studying intestinal parasites in humans and microbial pathogen contamination at environment was performed in a Laotian rural village to identify potential risks for disease outbreaks. A parasitological investigation was conducted in Ban Lak Sip village, Luang Prabang, Lao PDR involving fecal samples from 305 inhabitants as well as water samples taken from 3 sites of the local stream. Water analysis indicated the presence of several enteric pathogens, i.e., Aeromonas spp., Vibrio spp., E. coli H7, E...
October 2017: Korean Journal of Parasitology
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