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Mammary carcinoma

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https://www.readbyqxmd.com/read/27913437/surface-expression-of-tgf%C3%AE-docking-receptor-garp-promotes-oncogenesis-and-immune-tolerance-in-breast-cancer
#1
Alessandra Metelli, Bill X Wu, Caroline W Fugle, Saleh Rachidi, Shaoli Sun, Yongliang Zhang, Jennifer Wu, Stephen Tomlinson, Philip H Howe, Yi Yang, Elizabeth Garrett-Mayer, Bei Liu, Zihai Li
GARP encoded by the Lrrc32 gene is the cell surface docking receptor for latent TGFβ, which is expressed naturally by platelets and regulatory T cells (Treg). Although Lrrc32 is amplified frequently in breast cancer, the expression and relevant functions of GARP in cancer have not been explored. Here, we report that GARP exerts oncogenic effects, promoting immune tolerance by enriching and activating latent TGFβ in the tumor microenvironment. We found that human breast, lung, and colon cancers expressed GARP aberrantly...
October 20, 2016: Cancer Research
https://www.readbyqxmd.com/read/27908419/selenium-levels-in-human-breast-carcinoma-tissue-are-associated-with-a-common-polymorphism-in-the-gene-for-selenop-selenoprotein-p
#2
Dede N Ekoue, Sofia Zaichick, Klara Valyi-Nagy, Matthew Picklo, Craig Lacher, Kent Hoskins, Michael A Warso, Marcelo G Bonini, Alan M Diamond
Selenium supplementation of the diets of rodents has consistently been shown to suppress mammary carcinogenesis and some, albeit not all, human epidemiological studies have indicated an inverse association between selenium and breast cancer risk. In order to better understand the role selenium plays in breast cancer, 30 samples of tumor tissue were obtained from women with breast cancer and analyzed for selenium concentration, the levels of several selenium-containing proteins and the levels of the MnSOD anti-oxidant protein...
January 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/27879682/ziyuglycoside-i-inhibits-the-proliferation-of-mda-mb-231-breast-carcinoma-cells-through-inducing-p53-mediated-g2-m-cell-cycle-arrest-and-intrinsic-extrinsic-apoptosis
#3
Xue Zhu, Ke Wang, Kai Zhang, Ting Zhang, Yongxiang Yin, Fei Xu
BACKGROUND: Due to the aggressive clinical behavior, poor outcome, and lack of effective specific targeted therapies, triple-negative breast cancer (TNBC) has currently been recognized as one of the most malignant types of tumors. In the present study, we investigated the cytotoxic effect of ziyuglycoside I, one of the major components extracted from Chinese anti-tumor herbal Radix Sanguisorbae, on the TNBC cell line MDA-MB-231. METHODS: The underlying molecular mechanism of the cytotoxic effect ziyuglycoside I on MDA-MB-231 cells was investigated with cell viability assay, flow cytometric analysis and Western blot...
November 22, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27876705/genome-wide-gain-of-function-screen-for-genes-that-induce-epithelial-to-mesenchymal-transition-in-breast-cancer
#4
Dubravka Škalamera, Mareike Dahmer-Heath, Alexander J Stevenson, Cletus Pinto, Esha T Shah, Sheena M Daignault, Nur Akmarina B M Said, Melissa Davis, Nikolas K Haass, Elizabeth D Williams, Brett G Hollier, Erik W Thompson, Brian Gabrielli, Thomas J Gonda
Epithelial to mesenchymal transition (EMT) is a developmental program that has been implicated in progression, metastasis and therapeutic resistance of some carcinomas. To identify genes whose overexpression drives EMT, we screened a lentiviral expression library of 17000 human open reading frames (ORFs) using high-content imaging to quantitate cytoplasmic vimentin. Hits capable of increasing vimentin in the mammary carcinoma-derived cell line MDA-MB-468 were confirmed in the non-tumorigenic breast-epithelial cell line MCF10A...
August 16, 2016: Oncotarget
https://www.readbyqxmd.com/read/27874054/combinational-immunotherapy-with-allo-dribble-vaccines-and-anti-ox40-co-stimulation-leads-to-generation-of-cross-reactive-effector-t-cells-and-tumor-regression
#5
Guangjie Yu, Yuhuan Li, Zhihua Cui, Nicholas P Morris, Andrew D Weinberg, Bernard A Fox, Walter J Urba, Lixin Wang, Hong-Ming Hu
It is well-known that vaccines comprising of irradiated whole tumor cells or tumor-derived heat shock proteins can generate tumor-specific immune responses. In contrast, we showed recently that vaccines composed of autophagosomes (DRibbles) derived from syngeneic sarcomas could induce cross-reactive T-cell responses and cross-protection against the tumor. This unusual property of DRibbles was related to the selective recruitment of defective ribosomal products (DRiPs) and other short-lived proteins (SLiPs) into autophagosomes via sequestosome (SQSTM1, p62) mediated association of ubiquitinated SLiPs to the autophagy gene product LC3...
November 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27873102/fine-needle-cytology-in-the-follow-up-of-breast-carcinoma
#6
Anna Maria Cascone, Maria Siano, Basilio Angrisani, Rosa Maria Di Crescenzo, Alessandro Vatrella, Carmine Selleri, Francesco Salzano, Pio Zeppa
The postoperative follow-up strategies for breast carcinoma (BC) utilize different procedures; the aim of this study was to investigate the role of fine-needle cytology (FNC) in the follow-up of BC patients. Two hundred sixty-six FNC samples from 190 BC patients have been reviewed. The target anatomical sites were 190 breast including 155 ipsilateral and 145 contralateral breast lesions and 76 extra-mammary nodules. Extra-mammary lesions included lymph nodes, thyroidal nodules, soft tissue lesions, (subcutaneous and sub-scars), salivary glands and deep located masses...
November 21, 2016: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/27871834/ph-sensitive-pegylated-liposomes-for-delivery-of-an-acidic-dinitrobenzamide-mustard-prodrug-pathways-of-internalization-cellular-trafficking-and-cytotoxicity-to-cancer-cells
#7
Mimi M Yang, William R Wilson, Zimei Wu
This paper aims to develop and evaluate a pH-sensitive PEGylated liposomal (pPSL) system for tumor-targeted intracellular delivery of SN25860, a weakly acidic, poorly water-soluble dinitrobenzamide mustard prodrug which is activated by the E. coli nitroreductase nfB. pPSL and non pH-sensitive liposomes (nPSL), as reference, were formulated by thin-film hydration; an active drug loading method was developed with the aid of solubilizers. Cytotoxicity was evaluated in an nfsB-transfected EMT6 mouse mammary carcinoma cell line...
November 18, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27869160/pot1-ob-fold-mutations-unleash-telomere-instability-to-initiate-tumorigenesis
#8
P Gu, Y Wang, K K Bisht, L Wu, L Kukova, E M Smith, Y Xiao, S M Bailey, M Lei, J Nandakumar, S Chang
Chromosomal aberrations are a hallmark of human cancers, with complex cytogenetic rearrangements leading to genetic changes permissive for cancer initiation and progression. Protection of Telomere 1 (POT1) is an essential component of the shelterin complex and functions to maintain chromosome stability by repressing the activation of aberrant DNA damage and repair responses at telomeres. Sporadic and familial mutations in the oligosaccharide-oligonucleotide (OB) folds of POT1 have been identified in many human cancers, but the mechanism underlying how hPOT1 mutations initiate tumorigenesis has remained unclear...
November 21, 2016: Oncogene
https://www.readbyqxmd.com/read/27864452/identifying-progression-predictors-of-breast-ductal-carcinoma-in-situ
#9
REVIEW
Joe Yeong, Aye Aye Thike, Puay Hoon Tan, Jabed Iqbal
Ductal carcinoma in situ (DCIS) refers to neoplastic epithelial cells proliferating within the mammary ducts of the breast, which have not breached the basement membrane nor invaded surrounding tissues. Traditional thinking holds that DCIS represents an early step in a linear progression towards invasive ductal carcinoma (IDC). However, as only approximately half of DCIS cases progress to IDC, important questions around the key determinants of malignant progression need to be answered. Recent studies have revealed that molecular differences between DCIS and IDC cells are not found at the genomic level; instead, altered patterns of gene expression and post-translational regulation lead to distinct transcriptomic and proteomic profiles...
November 18, 2016: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/27861907/factors-predictive-of-failure-to-complete-planned-intraoperative-breast-radiation-using-the-intrabeam%C3%A2-system
#10
Lesly A Dossett, Andrea M Abbott, Weihong Sun, Loretta Loftus, Marie Catherine Lee, Roberto Diaz, Christine Laronga
PURPOSE: Intraoperative radiation therapy (IORT) is a form of breast irradiation that is delivered in a single session at the time of partial mastectomy. In up to 10% of patients, planned IORT is not completed; this leads to wasted resources and decreased patient satisfaction. Our objective was to evaluate factors associated with failure to complete planned IORT. METHODS AND MATERIALS: An IRB-approved review of planned IORT cases from 2011 to 2015 was conducted...
November 11, 2016: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27851913/regulatory-t-cells-exhibit-distinct-features-in-human-breast-cancer
#11
George Plitas, Catherine Konopacki, Kenmin Wu, Paula D Bos, Monica Morrow, Ekaterina V Putintseva, Dmitriy M Chudakov, Alexander Y Rudensky
Regulatory T (Treg) cells reside in lymphoid organs and barrier tissues where they control different types of inflammatory responses. Treg cells are also found in human cancers, and studies in animal models suggest that they contribute to cancer progression. However, properties of human intratumoral Treg cells and those present in corresponding normal tissue remain largely unknown. Here, we analyzed features of Treg cells in untreated human breast carcinomas, normal mammary gland, and peripheral blood. Tumor-resident Treg cells were potently suppressive and their gene-expression pattern resembled that of normal breast tissue, but not of activated peripheral blood Treg cells...
November 15, 2016: Immunity
https://www.readbyqxmd.com/read/27834468/expression-of-cd74-in-invasive-breast-carcinoma-its-relation-to-nottingham-prognostic-index-hormone-receptors-and-her2-immunoprofile
#12
Eiman Adel Hasby, Rana Adel Khalifa
PURPOSE: To study the immunohistochemical expression of CD74 in series of invasive breast carcinomas classified according to their estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) immunoprofile and explore its correlation to Nottingham Prognostic Index (NPI) and tumor pathologic stage to determine if it has a prognostic value. METHODS: A total of 160 cases of mammary carcinoma were classified broadly according to their ER, PR, and HER2 expression into luminal, HER2-positive, and triple-negative groups...
October 29, 2016: Tumori
https://www.readbyqxmd.com/read/27825136/pubertal-and-adult-windows-of-susceptibility-to-a-high-animal-fat-diet-in-trp53-null-mammary-tumorigenesis
#13
Yirong Zhu, Mark D Aupperlee, Yong Zhao, Ying Siow Tan, Erin L Kirk, Xuezheng Sun, Melissa A Troester, Richard C Schwartz, Sandra Z Haslam
Premenopausal breast cancer is associated with increased animal fat consumption among normal weight, but not overweight women (Farvid et al., 2014). Our previous findings in obesity-resistant BALB/c mice similarly showed promotion of carcinogen-induced mammary tumorigenesis by a diet high in saturated animal fat (HFD). This effect was specific to pubertal versus adult HFD. This study identifies the effects of HFD during puberty versus adulthood in Trp53-null transplant BALB/c mice and investigates its mechanism of enhancing tumorigenesis...
November 4, 2016: Oncotarget
https://www.readbyqxmd.com/read/27823365/description-of-the-prevalence-histologic-characteristics-concomitant-abnormalities-and-outcomes-of-mammary-gland-tumors-in-companion-rats-rattus-norvegicus-100-cases-1990-2015
#14
Claire Vergneau-Grosset, M Kevin Keel, Dayna Goldsmith, Philip H Kass, Joanne Paul-Murphy, Michelle G Hawkins
OBJECTIVE To describe the prevalence, histologic characteristics, concomitant abnormalities, and outcomes for various types of mammary gland tumors in companion rats (Rattus norvegicus). DESIGN Retrospective case series. ANIMALS 100 client-owned rats. PROCEDURES Medical records of companion rats that had an SC mass and were examined at a veterinary teaching hospital between 1990 and 2015 were reviewed. Information regarding the signalment, age at mass detection, reproductive sterilization status, histologic diagnosis of the SC mass, location of the initial and all subsequent SC masses, treatments administered, and clinical outcomes was extracted from each record and summarized...
November 15, 2016: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/27821709/proceedings-of-the-2016-national-toxicology-program-satellite-symposium
#15
Susan A Elmore, Vivian S Chen, Schantel Hayes-Bouknight, Jessica S Hoane, Kyathanahalli Janardhan, Linda H Kooistra, Thomas Nolte, Kathleen A Szabo, Gabrielle A Willson, Jeffrey C Wolf, David E Malarkey
The 2016 annual National Toxicology Program Satellite Symposium, entitled "Pathology Potpourri" was held in San Diego, CA, at the Society of Toxicologic Pathology's (STP) 35th annual meeting. The goal of this symposium was to present and discuss challenging diagnostic pathology and/or nomenclature issues. This article presents summaries of the speakers' talks, along with select images that were used by the audience for voting and discussion. Some lesions and topics covered during the symposium included malignant glioma and histiocytic sarcoma in the rodent brain; a new statistical method designed for histopathology data evaluation; uterine stromal/glandular polyp in a rat; malignant plasma cell tumor in a mouse brain; Schwann cell proliferative lesions in rat hearts; axillary schwannoma in a cat; necrosis and granulomatous inflammation in a rat brain; adenoma/carcinoma in a rat adrenal gland; hepatocyte maturation defect and liver/spleen hematopoietic defects in an embryonic mouse; distinguishing malignant glioma, malignant mixed glioma, and malignant oligodendroglioma in the rat; comparison of mammary gland whole mounts and histopathology from mice; and discussion of the International Harmonization of Nomenclature and Diagnostic Criteria collaborations...
November 7, 2016: Toxicologic Pathology
https://www.readbyqxmd.com/read/27820834/ccl2-ccr2-regulates-the-tumor-microenvironment-in-her-2-neu-driven-mammary-carcinomas-in-mice
#16
Xuguang Chen, Yunyue Wang, David Nelson, Sara Tian, Erin Mulvey, Bhumi Patel, Ilaria Conti, Juan Jaen, Barrett J Rollins
Chronic inflammation is a hallmark of cancer. Inflammatory chemokines, such as C-C chemokine ligand 2 (CCL2), are often present in tumors but their roles in cancer initiation and maintenance are not clear. Here we report that CCL2 promotes mammary carcinoma development in a clinically relevant murine model of breast cancer. Targeted disruption of Ccl2 slowed the growth of activated Her2/neu-driven mammary tumors and prolonged host survival. Disruption of Ccl2 was associated with a decrease in the development and mobilization of endothelial precursor cells (EPCs) which can contribute to tumor neovascularization...
2016: PloS One
https://www.readbyqxmd.com/read/27819674/mmtv-cre-ccn6-knockout-mice-develop-tumors-recapitulating-human-metaplastic-breast-carcinomas
#17
E E Martin, W Huang, T Anwar, C Arellano-Garcia, B Burman, J-L Guan, M E Gonzalez, C G Kleer
Metaplastic breast carcinoma is an aggressive form of invasive breast cancer with histological evidence of epithelial to mesenchymal transition (EMT). However, the defining molecular events are unknown. Here we show that CCN6 (WISP3), a secreted matricellular protein of the CCN (CYR61/CTGF/NOV) family, is significantly downregulated in clinical samples of human spindle cell metaplastic breast carcinoma. We generated a mouse model of mammary epithelial-specific Ccn6 deletion by developing a floxed Ccn6 mouse which was bred with an MMTV-Cre mouse...
November 7, 2016: Oncogene
https://www.readbyqxmd.com/read/27815463/effects-of-dietary-xanthophylls-canthaxanthin-and-astaxanthin-on-n-methyl-n-nitrosourea-induced-rat-mammary-carcinogenesis
#18
Takashi Yuri, Katsuhiko Yoshizawa, Yuko Emoto, Yuichi Kinoshita, Michiko Yuki, Airo Tsubura
BACKGROUND: Natural xanthophylls, canthaxanthin and astaxanthin are known to exhibit anticancer activity. However, the dietary effects of canthaxanthin and astaxanthin on N-methyl-N-nitrosourea (MNU)-induced mammary cancer remain controversial, and their mechanisms of action have not been clearly identified. MATERIALS AND METHODS: Three-week-old female Sprague-Dawley rats were fed a xanthophyll-free (basal diet) diet or experimental diets containing canthaxanthin or astaxanthin (0...
November 2016: In Vivo
https://www.readbyqxmd.com/read/27812285/a-multifaceted-role-for-myd88-dependent-signaling-in-progression-of-murine-mammary-carcinoma
#19
Mary J Higgins, Antonio Serrano, Kofi Y Boateng, Victoria A Parsons, Tiffany Phuong, Alyssa Seifert, Jacob M Ricca, Kyle C Tucker, Alec S Eidelman, Maureen A Carey, Robert A Kurt
Previous data obtained in our laboratory suggested that there may be constitutive signaling through the myeloid differentiation primary response gene 88 (Myd88)-dependent signaling cascade in murine mammary carcinoma. Here, we extended these findings by showing that, in the absence of an added Toll-like receptor (TLR) agonist, the myddosome complex was preformed in 4T1 tumor cells, and that Myd88 influenced cytoplasmic extracellular signal-regulated kinase (Erk)1/Erk2 levels, nuclear levels of nuclear factor-kappaB (NFκB) and signal transducer and activator of transcription 5 (STAT5), tumor-derived chemokine (C-C motif) ligand 2 (CCL2) expression, and in vitro and in vivo tumor growth...
2016: Breast Cancer: Basic and Clinical Research
https://www.readbyqxmd.com/read/27799536/intratumoral-injection-of-a-cpg-oligonucleotide-reverts-resistance-to-pd-1-blockade-by-expanding-multifunctional-cd8-t-cells
#20
Shu Wang, Jose Campos, Marilena Gallotta, Mei Gong, Chad Crain, Edwina Naik, Robert L Coffman, Cristiana Guiducci
Despite the impressive rates of clinical response to programmed death 1 (PD-1) blockade in multiple cancers, the majority of patients still fail to respond to this therapy. The CT26 tumor in mice showed similar heterogeneity, with most tumors unaffected by anti-PD-1. As in humans, response of CT26 to anti-PD-1 correlated with increased T- and B-cell infiltration and IFN expression. We show that intratumoral injection of a highly interferogenic TLR9 agonist, SD-101, in anti-PD-1 nonresponders led to a complete, durable rejection of essentially all injected tumors and a majority of uninjected, distant-site tumors...
November 15, 2016: Proceedings of the National Academy of Sciences of the United States of America
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