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https://www.readbyqxmd.com/read/29777335/a-trisubstituted-pyrazole-derivative-reduces-dmba-induced-mammary-tumor-growth-in-rats-by-inhibiting-estrogen-receptor-%C3%AE-expression
#1
Hanumappa Ananda, Kothanahally S Sharath Kumar, Muddenahalli S Sudhanva, Shobith Rangappa, Kanchugarakoppal S Rangappa
Aberrant expression of estrogen receptor alpha (ER-α) is observed in many pathological complications like breast cancer, endometrial cancer, and in osteoporosis. ER-α plays a vital role in the initiation and progression of breast cancer and confers chemo and radioresistance to the cancer cells by upregulating expression of anti-apoptotic proteins. The synthetic pyrazole derivative 3-(1-(4-bromophenyl)-5-phenyl-1H-pyrazol-3-yl)pyridine (compound 5d) displays significant cytotoxicity against mammary carcinoma cells...
May 18, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29774126/autophagy-deficient-breast-cancer-shows-early-tumor-recurrence-and-escape-from-dormancy
#2
Hussein F Aqbi, Liliya Tyutyunyk-Massey, Rebecca C Keim, Savannah E Butler, Theresa Thekkudan, Supriya Joshi, Timothy M Smith, Dipankar Bandyopadhyay, Michael O Idowu, Harry D Bear, Kyle K Payne, David A Gewirtz, Masoud H Manjili
Breast cancer patients who initially respond to cancer therapies often succumb to distant recurrence of the disease. It is not clear why people with the same type of breast cancer respond to treatments differently; some escape from dormancy and relapse earlier than others. In addition, some tumor clones respond to immunotherapy while others do not. We investigated how autophagy plays a role in accelerating or delaying recurrence of neu-overexpressing mouse mammary carcinoma (MMC) following adriamycin (ADR) treatment, and in affecting response to immunotherapy...
April 24, 2018: Oncotarget
https://www.readbyqxmd.com/read/29774109/sik2-attenuates-proliferation-and-survival-of-breast-cancer-cells-with-simultaneous-perturbation-of-mapk-and-pi3k-akt-pathways
#3
Neslihan Zohrap, Özge Saatci, Burcak Ozes, Ipek Coban, Hasan Murat Atay, Esra Battaloglu, Özgür Şahin, Kuyas Bugra
Salt Inducible Kinase2 (SIK2) has been shown to contribute to tumorigenesis in multiple tumor types in a dichotomous manner. However, little is known about its contribution to breast malignancies. Here, we report SIK2 as a potential tumor suppressor in breast cancer whose expression was reduced in tumor tissues and breast cancer cell lines compared to normal counterparts. In vitro loss- and gain-of-function experiments combined with xenograft studies demonstrated that SIK2-mediated attenuation of proliferation and survival of breast cancer cells with parallel inhibition of both Ras/Erk and PI3K/Akt pathways...
April 24, 2018: Oncotarget
https://www.readbyqxmd.com/read/29770317/metachronous-bilateral-ectopic-breast-carcinoma-a-case-report
#4
Anna Fachinetti, Corrado Chiappa, Veronica Arlant, Matteo Lavazza, Xiaoli Liu, Gianlorenzo Dionigi, Francesca Pia Pergolizzi, Antonina Catalfamo, Francesca Rovera
An incomplete regression of the mammary line during embryogenesis occurs in 0.2-6% of the population, which may result in the presence of ectopic breast tissue (EBT). The development of a carcinoma in the EBT is a rare event. The authors present a case report of a 76-year-old female patient, with a lobular carcinoma in an abdominal wall EBT submitted to surgery and adjuvant chemotherapy.
April 2018: Gland Surgery
https://www.readbyqxmd.com/read/29768565/cat-scratch-disease-presenting-as-axillary-lymphadenopathy-and-a-palpable-benign-mammary-nodule-mimicking-a-carcinoma
#5
Larissa Cabral Marques, Kátia Pincerato, Adriana Akemi Yoshimura, Felipe Eduardo Martins Andrade, Alfredo Carlos Simões Dornellas de Barros
We present a case involving a 74-year-old woman with cat scratch disease characterized by an enlarged and hard axillary lymph node as well as a palpable breast nodule mimicking a carcinoma. The lymph node and the breast nodule were excised. The pathologic examinations revealed granulomatous lymphadenitis with gram-negative bacilli and an intraductal papilloma. Antibiotic therapy (azithromycin) was prescribed and the patient's clinical evolution was excellent.
March 2018: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29763890/mir-301a-3p-suppresses-estrogen-signaling-by-directly-inhibiting-esr1-in-er%C3%AE-positive-breast-cancer
#6
Sandra Lettlova, Veronika Brynychova, Jan Blecha, David Vrana, Magdalena Vondrusova, Pavel Soucek, Jaroslav Truksa
BACKGROUND/AIMS: MiRNA-301a-3p is an oncogenic miRNA whose expression is associated with tumor development, metastases and overall poor prognosis. Estrogen receptor α (ERα) is one of the estrogen hormone-activated transcription factors, which regulates a large number of genes and is involved in the mammary gland development. Expression of ERα is considered to be a good indicator for endocrine therapy and breast cancer survival. Loss of ERα in breast cancer patients indicates invasiveness and poor prognosis...
2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29761734/functional-effects-of-trka-inhibition-on-system-x-c-mediated-glutamate-release-and-cancer-induced-bone-pain
#7
Tanya Miladinovic, Robert G Ungard, Katja Linher-Melville, Snezana Popovic, Gurmit Singh
Breast cancer cells release the signalling molecule glutamate via the system xC - antiporter, which is upregulated to exchange extracellular cystine for intracellular glutamate to protect against oxidative stress. Here, we demonstrate that this antiporter is functionally influenced by the actions of the neurotrophin nerve growth factor on its cognate receptor tyrosine kinase, TrkA, and that inhibiting this complex may reduce cancer-induced bone pain via its downstream actions on xCT, the functional subunit of system xC - ...
January 2018: Molecular Pain
https://www.readbyqxmd.com/read/29758207/lung-cancer-invading-a-coronary-graft-role-of-coronary-intervention-and-robotic-surgery
#8
Stephani C Wang, Hiren Patel, Walter W Scott
The treatment of primary lung cancer of the left upper lobe in those with prior coronary artery bypass graft is difficult to plan and execute due to potential for invasion into coronary grafts, particularly the left internal mammary. We present a patient with squamous cell carcinoma invading into coronary artery bypass grafts, but successfully treated by combination of percutaneous coronary intervention followed by video-assisted thoracoscopic surgery.
May 11, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29755597/5-fluorouracil-may-enrich-cancer-stem-cells-in-canine-mammary-tumor-cells-in-vitro
#9
Bin Zhou, Yipeng Jin, Di Zhang, Degui Lin
Mammary gland carcinomas are the most common neoplasms in women and unsterilized female dogs. Owing to the existence of cancer stem cells (CSCs), chemotherapy is not able to cure these types of diseases completely. A number of studies have demonstrated that CSCs are resistant to chemotherapeutic drugs, but whether canine mammary tumor cells that have acquired resistance to 5-fluorouracil (5-FU) exhibited properties of CSCs remains unknown. The aim of the present study was to investigate whether 5-fluorouracil-resistant canine mammary tumor cells exhibited properties of CSCs...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29755191/26s-proteasome-and-insulin-like-growth-factor-1-in-serum-of-dogs-suffering-from-malignant-tumors
#10
Ingrid Gerke, Franz-Josef Kaup, Stephan Neumann
Studies in humans have shown that the ubiquitin-proteasome pathway and the insulin-like growth factor axis are involved in carcinogenesis, thus, components of these systems might be useful as prognostic markers and constitute potential therapeutic targets. In veterinary medicine, only a few studies exist on this topic. Here, serum concentrations of 26S proteasome (26SP) and insulin-like growth factor-1 (IGF-1) were measured by canine enzyme-linked immunosorbent assay (ELISA) in 43 dogs suffering from malignant tumors and 21 clinically normal dogs (control group)...
April 2018: Canadian Journal of Veterinary Research, Revue Canadienne de Recherche Vétérinaire
https://www.readbyqxmd.com/read/29755131/kmt2c-mediates-the-estrogen-dependence-of-breast-cancer-through-regulation-of-er%C3%AE-enhancer-function
#11
Kinisha Gala, Qing Li, Amit Sinha, Pedram Razavi, Madeline Dorso, Francisco Sanchez-Vega, Young Rock Chung, Ronald Hendrickson, James Hsieh, Michael Berger, Nikolaus Schultz, Alessandro Pastore, Omar Abdel-Wahab, Sarat Chandarlapaty
Estrogen receptor alpha (ERα) is a ligand-activated nuclear receptor that directs proliferation and differentiation in selected cancer cell types including mammary-derived carcinomas. These master-regulatory functions of ERα require trans-acting elements such as the pioneer factor FOXA1 to establish a genomic landscape conducive to ERα control. Here, we identify the H3K4 methyltransferase KMT2C as necessary for hormone-driven ERα activity and breast cancer proliferation. KMT2C knockdown suppresses estrogen-dependent gene expression and causes H3K4me1 and H3K27ac loss selectively at ERα enhancers...
May 14, 2018: Oncogene
https://www.readbyqxmd.com/read/29752049/the-screening-and-electron-microscopy-observation-of-mammary-analogue-secretory-carcinoma-in-chinese
#12
Yi Zhong, Liu Liu, Bin Qi, Xiaoling Song, Linhan Shen, Hongwei Li
Mammary analogue secretory carcinoma of salivary gland (MASC) is a tumor with histopathologic and immunophenotypic features mimicking secretory carcinoma of the breast harboring the ETV6 split. The expression of mammaglobin, S-100, Ki-67, P63 and ETV6 split were detected in twelve cases of acinar cell carcinoma and fourteen cases of mammary analogue secretory carcinoma of salivary gland by immunohistochemistry and fluorescence in situ hybridization respectively. The expression of ETV6 gene split was detected in fourteen mammary analogue secretory carcinomas of salivary gland with positive expression of mammaglobin...
October 19, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29750424/stat3-oct-4-c-myc-signal-circuit-for-regulating-stemness-mediated-doxorubicin-resistance-of-triple-negative-breast-cancer-cells-and-inhibitory-effects-of-wp1066
#13
Cong-Cong Cheng, Li-Hong Shi, Xue-Jian Wang, Shu-Xiao Wang, Xiao-Qing Wan, Shu-Rong Liu, Yi-Fei Wang, Zhong Lu, Li-Hua Wang, Yi Ding
Doxorubicin (Dox) is widely used in the treatment of triple-negative breast cancer cells (TNBCs), however resistance limits its effectiveness. Cancer stem cells (CSCs) are associated with Dox resistance in MCF-7 estrogen receptor positive breast cancer cells. Signal transducer and activator of transcription 3 (Stat3) may functionally shift non-CSCs towards CSCs. However, whether Stat3 drives the formation of CSCs during the development of resistance in TNBC, and whether a Stat3 inhibitor reverses CSC-mediated Dox resistance, remains to be elucidated...
May 8, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29749427/anti%C3%A2-cancer-effects-of-fisetin-on-mammary-carcinoma-cells-via-regulation-of-the-pi3k-akt-mtor-pathway-in-vitro-and-in-vivo-studies
#14
Xu Sun, Xueman Ma, Qiwei Li, Yong Yang, Xiaolong Xu, Jiaqi Sun, Mingwei Yu, Kexin Cao, Lin Yang, Guowang Yang, Ganlin Zhang, Xiaomin Wang
Fisetin, a natural flavonoid found in a variety of edible and medical plants, has been suggested to inhibit the proliferation of various tumor cells and to induce apoptosis. However, the effects of fisetin on breast cancer have rarely been reported and the underlying mechanism is still undefined. The present study explored the anti‑cancer effects of fisetin on mammary carcinoma cells and the underlying mechanisms. Following treatment with fisetin, viability of 4T1, MCF‑7 and MDA‑MB‑231 cells were measured by MTT assay...
May 2, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29748834/qbd-based-development-of-%C3%AE-linolenic-acid-potentiated-nanoemulsion-for-targeted-delivery-of-doxorubicin-in-dmba-induced-mammary-gland-carcinoma-in-vitro-and-in-vivo-evaluation
#15
Chandra Bhushan Tripathi, Poonam Parashar, Malti Arya, Mahendra Singh, Jovita Kanoujia, Gaurav Kaithwas, Shubhini A Saraf
Breast cancer is the most common cancer of occurrence in women and has the highest mortality incidence rate therein. The present study envisaged to develop doxorubicin (Dox) loaded folate functionalized nanoemulsion (NE) for profound therapeutic activity against mammary gland cancer. NE was prepared using pseudo-ternary phase diagrams utilizing α-linolenic acid (ALA) as lipid phase, to further enhance the anticancer potential of Dox. Box-Behnken design was employed to systematically develop the NE. Optimized NE (f-Dox-NE) was evaluated for in vitro and in vivo performance...
May 10, 2018: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29746168/proangiogenic-effects-of-tumor-cells-on-endothelial-progenitor-cells-vary-with-tumor-type-in-an-in-vitro-and-in-vivo-rat-model
#16
Ran An, Rafael Schmid, Anne Klausing, Jan W Robering, Maximilian Weber, Tobias Bäuerle, Rainer Detsch, Aldo R Boccaccini, Raymund E Horch, Anja M Boos, Annika Weigand
Endothelial progenitor cells (EPCs) contribute to neovascularization in tumors. However, the relationship of EPCs and tumor-induced angiogenesis still remains to be clarified. The present study aimed at investigating the influence of 4 different tumor types on angiogenic properties of EPCs in an in vitro and in vivo rat model. It could be demonstrated that in vitro proliferation, migration, and angiogenic abilities and genetic modifications of EPCs are controlled in a tumor-type-dependent manner. The proangiogenic effect of mammary carcinoma, osteosarcoma, and rhabdomyosarcoma cells was more pronounced compared to colon carcinoma cells...
May 10, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29738110/genotoxic-stress-induces-sca-1-expressing-metastatic-mammary-cancer-cells
#17
Jianlin Gong, Benjamin J Lang, Desheng Weng, Takanori Eguchi, Ayesha Murshid, Thiago J Borges, Sachin Doshi, Baizheng Song, Mary Ann Stevenson, Stuart K Calderwood
We describe a cell damage-induced phenotype in mammary carcinoma cells involving acquisition of enhanced migratory and metastatic properties. Induction of this state by radiation required increased activity of the Ptgs2 gene product cyclooxygenase 2 (Cox2), secretion of its bioactive lipid product prostaglandin E2 (PGE2) and the activity of the PGE2 receptor EP4. Although largely transient, decaying to low levels in a few days to a week, this phenotype was cumulative with damage and levels of cell markers Sca-1 and ALDH1 increased with treatment dose...
May 8, 2018: Molecular Oncology
https://www.readbyqxmd.com/read/29733437/complex-mammary-carcinoma-with-metastases-to-lymph-nodes-subcutaneous-tissue-and-multiple-joints-in-a-dog
#18
Maggie R McCourt, Alexandra M Dieterly, Paige E Mackey, Shane D Lyon, Theresa E Rizzi, Jerry W Ritchey
An 8-year-old, intact female, mixed-breed dog presented to the Oklahoma State University Boren Veterinary Medical Teaching Hospital for evaluation of progressive lameness and joint effusion of multiple joints. Physical examination revealed joint effusion of the elbow, hock, and stifle joints bilaterally, enlarged left axillary and right popliteal lymph nodes, a subcutaneous mass over the left elbow, and a subcutaneous mass involving the left second and third mammary glands. Cytologic examination of the mammary mass, enlarged lymph nodes, and joint fluid from most affected joints revealed a monomorphic population of loosely cohesive neoplastic epithelial cells...
May 7, 2018: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/29733018/the-revisited-role-of-ultrasound-guided-core-needle-biopsy-in-the-breast-cancer-diagnosis
#19
Flavius Mocian, Rareş Georgescu, Marius Florin Coroş, Ioana Colcer, Bauer Orsolya Hanko, Adela-Luciana Oprea, Simona Stolnicu
Background: Core needle biopsy (CNB) is an alternative to surgical biopsy in establishing the histopathological diagnosis of mammary lesions. AIM OF THE STUDY: The aim is to determine the accuracy of ultrasound guided CNB (US-CNB) in establishing breast cancer diagnosis. MATERIALS AND METHODS: We retrospectively analyzed the data of US-CNB patients between May 2012 - December 2014. One hundred sixty-three biopsies were performed in 155 patients. To assess the diagnostic accuracy of US-CNB, the results were correlated with the gold-standard of surgical excision of the breast lesions, thus, 90 patients (94 breast lesions) were included in the study group...
March 2018: Chirurgia
https://www.readbyqxmd.com/read/29726404/feasibility-study-of-fe-sub-3-sub-o-sub-4-sub-tao-sub-x-sub-nanoparticles-as-a-radiosensitizer-for-proton-therapy
#20
Sang Hee Ahn, Nohyun Lee, Changhoon Choi, Sung Won Shin, Youngyih Han, Hee Chul Park
We investigated the feasibility of using multifunctional Fe3O4/TaOx (core/shell) nanoparticles, developed for use in contrast agents for computed tomography (CT) and magnetic resonance imaging (MRI), as dose-enhancing radiosensitizers. First, to verify the detectability of Fe3O4/TaOx nanoparticles in imaging, in vivo tests were conducted. Approximately 600 mg/kg of 19-nm-diameter Fe3O4/TaOx nanoparticles dispersed in phosphate-buffered saline was injected into the tail vein of six Balb/c mice used as tumour (4T1 mammary carcinoma cell) models...
May 4, 2018: Physics in Medicine and Biology
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