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Mammary carcinoma

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https://www.readbyqxmd.com/read/28929545/additional-diagnostic-features-of-mammary-analogue-secretory-carcinoma-on-cytology
#1
M F Gonzalez, I Akhtar, V Manucha
No abstract text is available yet for this article.
September 19, 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/28915769/robotic-lymphadenectomy-of-an-internal-mammary-lymph-node-metastasis
#2
Ludovic Melly, Jean-Luc Jansens, Grégroy Kalscheuer, Asmae Belhaj, Benoît Rondelet
A 58-year-old woman was diagnosed with a left-sided lone internal mammary swollen lymph node on a routine follow-up computer tomography, 42 months after a left mastectomy in the context of a ductal carcinoma grade III. The suspected metastasis was successfully removed in toto using a 3-port-da Vinci robotic procedure and the patient was discharged home without any complication on the third postoperative day. Robotically assisted oncological lymph node removal is safe, easily performed and economically affordable...
September 15, 2017: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/28915553/identification-of-a-novel-p53-target-col17a1-that-inhibits-breast-cancer-cell-migration-and-invasion
#3
Varalee Yodsurang, Chizu Tanikawa, Takafumi Miyamoto, Paulisally Hau Yi Lo, Makoto Hirata, Koichi Matsuda
p53 mutation is a marker of poor prognosis in breast cancers. To identify downstream targets of p53, we screened two transcriptome datasets, including cDNA microarrays of MCF10A breast epithelial cells with wild-type p53 or p53-null background, and RNA sequence analysis of breast invasive carcinoma. Here, we unveil ten novel p53 target candidates that are up-regulated after the induction of p53 in wild-type cells. Their expressions are also high in breast invasive carcinoma tissues with wild-type p53. The GO analysis identified epidermis development and ectoderm development, which COL17A1 participates, as significantly up-regulated by wild-type p53...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28915525/infiltrating-mammary-duct-adenocarcinoma-in-the-right-labia-majora-along-the-milk-line
#4
Haitham Atef Torky, Anwar Elshenawy, Ahmed Eesa
Introduction Breast tissue rarely arises from the vulva and malignancy might develop in it. Case Thirty-eight-year-old woman presented with a suspicious ulcer in the right labia majora discovered accidently and removed by wide local excision. Histopathology revealed infiltrating mammary duct adenocarcinoma along the milk line. Immunohistochemistry was positive for estrogen and progesterone receptors and equivocal overexpression for HER2 protein with a score of 2+. Metastatic work-up was clear. Inguinal lymph nodes were enlarged and lymphadenectomy done which showed positive lymph nodes on the right side and none on the left...
September 15, 2017: Zeitschrift Für Geburtshilfe und Neonatologie
https://www.readbyqxmd.com/read/28903354/her2-isoforms-co-expression-differently-tunes-mammary-tumor-phenotypes-affecting-onset-vasculature-and-therapeutic-response
#5
Arianna Palladini, Giordano Nicoletti, Alessia Lamolinara, Massimiliano Dall'Ora, Tania Balboni, Marianna L Ianzano, Roberta Laranga, Lorena Landuzzi, Veronica Giusti, Claudio Ceccarelli, Donatella Santini, Mario Taffurelli, Enrico Di Oto, Sofia Asioli, Augusto Amici, Serenella M Pupa, Carla De Giovanni, Elda Tagliabue, Manuela Iezzi, Patrizia Nanni, Pier-Luigi Lollini
Full-length HER2 oncoprotein and splice variant Delta16 are co-expressed in human breast cancer. We studied their interaction in hybrid transgenic mice bearing human full-length HER2 and Delta16 (F1 HER2/Delta16) in comparison to parental HER2 and Delta16 transgenic mice. Mammary carcinomas onset was faster in F1 HER2/Delta16 and Delta16 than in HER2 mice, however tumor growth was slower, and metastatic spread was comparable in all transgenic mice. Full-length HER2 tumors contained few large vessels or vascular lacunae, whereas Delta16 tumors presented a more regular vascularization with numerous endothelium-lined small vessels...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28901484/molecular-iodine-impairs-chemoresistance-mechanisms-enhances-doxorubicin-retention-and-induces-downregulation-of-the-cd44-cd24-and-e-cadherin-vimentin-subpopulations-in-mcf-7-cells-resistant-to-low-doses-of-doxorubicin
#6
Alexander Bontempo, Brenda Ugalde-Villanueva, Evangelina Delgado-González, Ángel Luis Rodríguez, Carmen Aceves
One of the most dreaded clinical events for an oncology patient is resistance to treatment. Chemoresistance is a complex phenomenon based on alterations in apoptosis, the cell cycle and drug metabolism, and it correlates with the cancer stem cell phenotype and/or epithelial-mesenchymal transition. Molecular iodine (I2) exerts an antitumor effect on different types of iodine-capturing neoplasms by its oxidant/antioxidant properties and formation of iodolipids. In the present study, wild-type breast carcinoma cells (MCF-7/W) were treated chronically with 10 nM doxorubicin (DOX) to establish a low-dose DOX-resistant mammary cancer model (MCF-7/D)...
September 1, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28901321/supplemental-conventional-transarterial-embolization-chemoembolization-therapy-via-extrahepatic-arteries-for-hepatocellular-carcinoma
#7
Yuanqan Huang, Zhongzhi Jia, Jianfei Tu, Tao Shen, Feng Tian, Guomin Jiang
PURPOSE: To assess the value of conventional transarterial embolization/chemoembolization (cTAE/TACE) therapy via extrahepatic arteries for patients with unresectable hepatocellular carcinoma (HCC). METHODS: Patients with unresectable HCC who underwent cTAE/TACE therapy via extrahepatic arteries between May 2008 and July 2016 across 4 medical centers were identified. The technical success, serum alpha-fetoprotein (AFP) levels changes, tumor response, disease control rate, survival rate, and major complication were analyzed...
2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28900337/mammary-myofibroblastoma-with-unusual-morphological-and-immunohistochemical-features
#8
Ons Boudaouara, Chiraz Chaari, Abdelkhalek Hassini, Tahya Sellami Boudaouara
Mammary myofibroblastoma (MFB) is a rare mesenchymal tumor, derived from mammary stromal fibro/myofibroblasts, which has various morphological features and characteristic immunohistochemical staining. The epithelioid morphologic variant is defined, accordingly, as a proliferation of exclusively or predominantly (>50%) epithelioid cells, variably embedded in a myxoid to fibrous stroma. These histological and cytological features may pose a diagnostic challenge mainly with metaplastic carcinoma and invasive lobular carcinoma of the breast...
April 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/28895057/triterpenoid-saponins-from-clinopodium-chinense-benth-o-kuntze-and-their-biological-activity
#9
Yin-Di Zhu, Jing-Yi Hong, Feng-Da Bao, Na Xing, Ling-Tian Wang, Zhong-Hao Sun, Yun Luo, Hai Jiang, Xu-Dong Xu, Nai-Liang Zhu, Hai-Feng Wu, Gui-Bo Sun, Jun-Shan Yang
Four new ursane-type triterpenoid saponins, clinopoursaponins A-D (1-4), six new oleanane-type triterpenoid saponins, clinopodiside VII-XII (5-10), as well as eight known triterpene analogues (11-18), were isolated from the aerial parts of Clinopodium chinense (Benth.) O. Kuntze. The structures of the new compounds were determined based on extensive spectral analyses, including 1D ((1)H and (13)C) and 2D NMR experiments (COSY, NOESY, HSQC, 2D TOCSY, HSQC-TOCSY and HMBC), HR-ESI-MS and chemical methods. Compounds 1-18 were evaluated for their protective effects against anoxia/reoxygenation-induced apoptosis in H9c2 cells and cytotoxicities against murine mammary carcinoma cell line 4T1...
September 11, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/28890745/a-simple-and-practical-method-for-setting-up-a-criterion-of-projection-of-silicone-breast-implant-after-simple-mastectomy
#10
Naohiro Ishii, Jiro Ando, Michiko Harao, Masaru Takemae, Kazuo Kishi
Objective: In breast reconstruction, decision of projection of silicone breast implant in tissue expander replacement is difficult because of the need to consider several parameters that cannot be expressed in accurate numerical form. The present study aimed at a quantitative analysis based on decreased projection of the reconstructed side compared with silicone breast implant projection and to develop a new method for simple and practical decision of silicone breast implant projection. Methods: Thirty-five patients who had mammary carcinoma and were treated with simple mastectomy, tissue expander insertion, and replacement with anatomical silicone breast implant from April 2013 to March 2016 were retrospectively identified...
2017: Eplasty
https://www.readbyqxmd.com/read/28890195/gk-1-peptide-reduces-tumor-growth-decreases-metastatic-burden-and-increases-survival-in-a-murine-breast-cancer-model
#11
D Torres-García, A Pérez-Torres, K Manoutcharian, U Orbe, R Servín-Blanco, G Fragoso, E Sciutto
GK-1 is a parasite-derived peptide adjuvant of 18 amino acid-length that enhances T-cell function and increases survival in B16-F10 melanoma tumor-bearing mice. This study was designed to evaluate in vivo the antitumor efficacy of GK-1 on 4T1 mouse mammary carcinoma. BALB/c mice with palpable primary tumors were weekly intravenously injected three times with saline solution or three different concentrations (10, 50, or 100μg per mouse) of GK-1. GK-1 significantly increased lifespan (p<0.0001) and reduced the primary tumor weight (p=0...
September 7, 2017: Vaccine
https://www.readbyqxmd.com/read/28889723/expression-of-c-myc-and-%C3%AE-catenin-and-their-correlation-in-triple-negative-breast-cancer
#12
Jiankui Wang, Mei Li, Dedian Chen, Jianyun Nie, Yan Xi, Xiaojuan Yang, Yun Chen, Zhuanqing Yang
BACKGROUND: The present study was planned to study the expression of C-myc and β- catenin in triple negative breast cancer (TNBC) tissue. Furthermore, their relations to clinical features of the tumor and the survival prognosis were also studied. Additionally, correlation was evaluated between the expression of C-myc and β- catenin to provide the theoretical basis for the targeted therapy of TNBC. METHODS: 60 cases of patients diagnosed with TNBC for the first time were selected for the study...
September 8, 2017: Minerva Medica
https://www.readbyqxmd.com/read/28881673/bromodomain-inhibition-shows-antitumoral-activity-in-mice-and-human-luminal-breast-cancer
#13
Montserrat Pérez-Salvia, Laia Simó-Riudalbas, Pere Llinàs-Arias, Laura Roa, Fernando Setien, Marta Soler, Manuel Castro de Moura, James E Bradner, Eva Gonzalez-Suarez, Catia Moutinho, Manel Esteller
BET bromodomain inhibitors, which have an antitumoral effect against various solid cancer tumor types, have not been studied in detail in luminal breast cancer, despite the prevalence of this subtype of mammary malignancy. Here we demonstrate that the BET bromodomain inhibitor JQ1 exerts growth-inhibitory activity in human luminal breast cancer cell lines associated with a depletion of the C-MYC oncogene, but does not alter the expression levels of the BRD4 bromodomain protein. Interestingly, expression microarray analyses indicate that, upon JQ1 administration, the antitumoral phenotype also involves downregulation of relevant breast cancer oncogenes such as the Breast Carcinoma-Amplified Sequence 1 (BCAS1) and the PDZ Domain-Containing 1 (PDZK1)...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28881584/dimerization-of-egfr-and-her2-induces-breast-cancer-cell-motility-through-stat1-dependent-acta2-induction
#14
Myeongjin Jeon, Daeun You, Soo Youn Bae, Seok Won Kim, Seok Jin Nam, Hyeon Ho Kim, Sangmin Kim, Jeong Eon Lee
The dimerization of EGFR and HER2 is associated with poor prognosis such as induction of tumor growth and cell invasion compared to when EGFR remains as a homodimer. However, the mechanism for events after dimerization in breast cancer models is not clear. We found that expressions of alpha-smooth muscle actin (ACTA2) and signal transducer and activator of transcription 1 (STAT1) significantly increased with transient or stable overexpression of HER2 in EGFR-positive breast cancer cells. ACTA2 and STAT1 expression was also increased in HER2-positive breast cancer patients...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28880889/loss-of-kaiso-expression-in-breast-cancer-cells-prevents-intra-vascular-invasion-in-the-lung-and-secondary-metastasis
#15
Jacek M Kwiecien, Blessing I Bassey-Archibong, Wojciech Dabrowski, Lyndsay G Rayner, Alexandra R Lucas, Juliet M Daniel
The metastatic activity of breast carcinomas results from complex genetic changes in epithelial tumor cells and accounts for 90% of deaths in affected patients. Although the invasion of the local lymphatic vessels and veins by malignant breast tumor cells and their subsequent metastasis to the lung, has been recognized, the mechanisms behind the metastatic activity of breast tumor cells to other distal organs and the pathogenesis of metastatic cancer are not well understood. In this study, we utilized derivatives of the well-established and highly metastatic triple negative breast cancer (TNBC) cell line MDA-MB-231 (MDA-231) to study breast tumor metastasis in a mouse model...
2017: PloS One
https://www.readbyqxmd.com/read/28870936/subcellular-localization-of-maspin-correlates-with-histone-deacetylase-1-expression-in-human-breast-cancer
#16
Makoto Wakahara, Tomohiko Sakabe, Yasuaki Kubouchi, Keiko Hosoya, Yumi Hirooka, Yohei Yurugi, Kanae Nosaka, Tatsushi Shiomi, Hiroshige Nakamura, Yoshihisa Umekita
BACKGROUND/AIM: Maspin is known to be a tumor suppressor protein. Its nuclear localization and endogenous inhibition of histone deacetylase 1 (HDAC1) are considered crucial for its tumor suppressor activity. However, it remains unclear whether subcellular localization of maspin correlates with HDAC1 expression level in human breast cancer. PATIENTS AND METHODS: Immunohistochemical analyses were performed on 164 resected specimens of invasive breast carcinoma using antibodies for maspin and HDAC1...
September 2017: Anticancer Research
https://www.readbyqxmd.com/read/28870114/alleviating-mechanical-allodynia-and-modulating-cellular-immunity-contribute-to-electroacupuncture-s-dual-effect-on-bone-cancer-pain
#17
Yi Liang, Jun-Ying Du, Jun-Fan Fang, Ruo-Yi Fang, Jie Zhou, Xiao-Mei Shao, Yong-Liang Jiang, Yi-Tian Chen, Jian-Qiao Fang
HYPOTHESIS: Electroacupuncture (EA) has been used as an alternative analgesic therapy for hundreds of years, yet its analgesic potency and therapeutic advantage against bone cancer pain (BCP) in comparison with morphine remains unclear. This study aimed to investigate the effects of EA on mechanical allodynia and cellular immunity of BCP rats, and to further explore the potential mechanism. METHODS: The BCP model was established by implanting Walker 256 mammary gland carcinoma cells into the left tibia of adult female Sprague-Dawley rats...
September 1, 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/28865492/pathobiology-of-the-129-stat1-mouse-model-of-human-age-related-er-positive-breast-cancer-with-an-immune-infiltrate-excluded-phenotype
#18
Hidetoshi Mori, Jane Q Chen, Robert D Cardiff, Zsófia Pénzváltó, Neil E Hubbard, Louis Schuetter, Russell C Hovey, Josephine F Trott, Alexander D Borowsky
BACKGROUND: Stat1 gene-targeted knockout mice (129S6/SvEvTac-Stat1 (tm1Rds)) develop estrogen receptor-positive (ER(+)), luminal-type mammary carcinomas at an advanced age. There is evidence for both host environment as well as tumor cell-intrinsic mechanisms to initiate tumorigenesis in this model. In this report, we summarize details of the systemic and mammary pathology at preneoplastic and tumor-bearing time points. In addition, we investigate tumor progression in the 129:Stat1 (-/-) host compared with wild-type 129/SvEv, and we describe the immune cell reaction to the tumors...
September 2, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28863309/polymeric-nanoparticles-of-sirna-prepared-by-a-double-emulsion-solvent-diffusion-technique-physicochemical-properties-toxicity-biodistribution-and-efficacy-in-a-mammary-carcinoma-mice-model
#19
Meital Ben David-Naim, Etty Grad, Gil Aizik, Mirjam M Nordling-David, Ofra Moshel, Zvi Granot, Gershon Golomb
siRNA-loaded nanoparticles (NPs) administered systemically can overcome the poor stability and rapid elimination of free double-stranded RNA in circulation, resulting in increased tumor accumulation and efficacy. siRNA against osteopontin (siOPN), a protein involved in breast cancer development, was encapsulated in poly(D,L-lactic-co-glycolic acid) NPs by a double emulsion solvent diffusion (DESD) technique. We also compared the effect of polyethylenimine (PEI) molecular weight (800 Da and 25 kDa), used as the counter-ion for siRNA complexation, on the physicochemical properties of the NPs, cytotoxicity, and cellular uptake...
August 23, 2017: Biomaterials
https://www.readbyqxmd.com/read/28862125/solitary-adrenal-metastases-from-breast-invasive-ductal-carcinoma
#20
Cezar Stroescu, Iulian Gilca, Dragoş Chirita, Radu Poenaru, Ana Puşcaşu, Diana Pescaru, Adelina Birceanu, Cornelia Niţipir, Narcis Copcă
The usual neoplastic dissease involving suprarenal glands are adrenal metastaes. The majority of suprarenal metastatic disease arise from lung cancer, followed by the stomach and colon cancer, oesophagus, the liver/bile ducts cancer and renal cell carcinoma. Invasive mammary carcinoma usually spreads to the bones, lungs, lymph nodes, liver and the brain. Adrenal gland metastases from invasive no special type carcinoma represents an extremly low rate number of cases. We discuss about a 66 year old patient who presented with a solitary adrenal metastases from triple negative breast invasive carcinoma...
July 2017: Chirurgia
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