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Nele A J De Witte, Stefan Sütterlin, Caroline Braet, Sven C Mueller
Emotion regulation and associated autonomic activation develop throughout childhood and adolescence under the influence of the family environment. Specifically, physiological indicators of autonomic nervous system activity such as interoceptive sensitivity and vagally mediated heart rate variability (HRV) can inform on emotion regulation. Although the effect of parental emotion socialization on emotion regulation appears to be influenced by autonomic processes, research on physiological regulation and the influence of parental factors remains scarce...
2016: PloS One
Olga Pollatos, Beate M Herbert, Götz Berberich, Michael Zaudig, Till Krauseneck, Manos Tsakiris
Background: Interoceptive abilities are known to be affected in anorexia nervosa (AN). Previous studies could show that private self-focus can enhance interoceptive accuracy (IAcc) in healthy participants. As body dissatisfaction is high in AN, confrontation with bodily features such as the own face might have a directly opposed effect in AN. Whether patients with AN can benefit from self-focus in their IAcc and whether this pattern changes over the time-course of cognitive behavioral therapy was investigated in this study...
2016: Frontiers in Human Neuroscience
Erin A Brosey, Neil D Woodward
BACKGROUND: Aberrations in body perception are common in psychotic disorders. The insula and temporoparietal junction (TPJ) are involved in body ownership and spatial perception suggesting that abnormal structure of these regions might be related to the expression of perceptual aberrations in psychosis. METHODS: 58 individuals with a primary psychotic disorder and 40 healthy subjects completed the Chapman Perceptual Aberration Scale (PAS) and underwent structural magnetic resonance imaging (MRI)...
October 8, 2016: Schizophrenia Research
Tal Shafir
Emotion regulation is a person's active attempt to manage their emotional state by enhancing or decreasing specific feelings. Peripheral theories of emotion argue that the origins of emotions stem from bodily responses. This notion has been reformulated in neurophysiological terms by Damasio, who claimed that emotions are generated by conveying the current state of the body to the brain through interoceptive and proprioceptive afferent input. The resulting brain activation patterns represent unconscious emotions and correlate with conscious feelings...
2016: Frontiers in Psychology
Min-Kyoung Kim, Borah Kim, Tai Kiu Choi, Sang-Hyuk Lee
BACKGROUND: Anxiety sensitivity (AS) refers to a fear of anxiety-related sensations and is a dispositional variable especially elevated in patients with panic disorder (PD). Although several functional imaging studies of AS in patients with PD have suggested the presence of altered neural activity in paralimbic areas such as the insula, no study has investigated white matter (WM) alterations in patients with PD in relation to AS. The objective of this study was to investigate the WM correlates of AS in patients with PD...
October 3, 2016: Journal of Affective Disorders
Mariachiara Longarzo, M Quarantelli, M Aiello, M Romano, A Del Prete, C Cimminiello, S Cocozza, G Olivo, C Loguercio, L Trojano, D Grossi
Irritable bowel syndrome (IBS) is characterized by visceral hypersensitivity likely related to altered processing of sensory stimuli along the brain-gut axis. Previous neuroimaging studies demonstrated structural and functional alteration of several brain areas involved in bodily representation, e.g. the insula, in patients with IBS. By means of resting-state functional magnetic resonance imaging (rs-fMRI) we searched for alteration of functional connectivity within the network involved in self-bodily consciousness...
October 4, 2016: Brain Imaging and Behavior
Thomas Forkmann, Anne Scherer, Judith Meessen, Matthias Michal, Hartmut Schächinger, Claus Vögele, André Schulz
Garfinkel and Critchley (2013) recently proposed a three level model of interoception. Only few studies, however, have empirically tested this theoretical model thus far. The present study aimed at investigating (1) the central assumptions of this model, i.e. that Accuracy, Sensibility and Awareness are distinguishable facets of interoception and that Interoceptive Accuracy is the basic level of interoception, and (2) whether cardiovascular activation (as indexed by heart rate) is differentially related to the three facets of interoception...
October 1, 2016: International Journal of Psychophysiology
Yael I Nillni, Suzanne L Pineles, Kelly J Rohan, Michael J Zvolensky, Ann M Rasmusson
Clinically significant premenstrual symptoms (PMS) is conceptualized as a depressive disorder in DSM-5, however, it may share pathophysiological processes with anxiety- and fear-related disorders. Specifically, women with PMS panic at higher rates during biological challenge procedures. It is unclear if this increased interoceptive sensitivity is a general vulnerability or specific to the premenstrual phase. The current study examined the role of menstrual cycle phase on reactivity to a CO2 challenge among women with (n = 11) and without (n = 26) clinically significant PMS (N = 37)...
September 30, 2016: Cognitive Behaviour Therapy
Carmel Mary Martin
RATIONALE: Much is written about "multimorbidity" as it is a difficult problem for health systems, as it reflects a complex phenomenon unique to each individual health journey and health service context. This paper proposes the adoption of 2 constructs or knowledge streams into mainstream "multimorbidity" care which are arguably most important to person-centered care-personal health perceptions and resilience. ANALYSIS: "Multimorbidity" is the manifestation of multiple nonlinear physical, psychosocial, and environmental phenomena in an individual health journey...
September 21, 2016: Journal of Evaluation in Clinical Practice
Leah Dudley, Richard J Stevenson
Many neuropsychological and animal lesion studies point to the hippocampus as being critical for mediating interoceptive awareness, while neuroimaging studies have been used to argue for the importance of the insula and anterior cingulate cortex. Here, using healthy young adults - as with the neuroimaging data - we tested for an association between performance on a hippocampal dependent learning and memory (HDLM) measure (logical memory percent retention) and interoceptive awareness assessed on three tasks - heart rate tracking, water loading and the Multidimensional Assessment of Interoceptive Awareness questionnaire (MAIA)...
September 16, 2016: Brain and Cognition
Narayanan Kandasamy, Sarah N Garfinkel, Lionel Page, Ben Hardy, Hugo D Critchley, Mark Gurnell, John M Coates
Interoception is the sensing of physiological signals originating inside the body, such as hunger, pain and heart rate. People with greater sensitivity to interoceptive signals, as measured by, for example, tests of heart beat detection, perform better in laboratory studies of risky decision-making. However, there has been little field work to determine if interoceptive sensitivity contributes to success in real-world, high-stakes risk taking. Here, we report on a study in which we quantified heartbeat detection skills in a group of financial traders working on a London trading floor...
2016: Scientific Reports
Huynh Giao Ly, Patrick Dupont, Koen Van Laere, Inge Depoortere, Jan Tack, Lukas Van Oudenhove
BACKGROUND: Rapid gastric balloon distension to discomfort threshold activates the "pain neuromatrix" and deactivates exteroceptive sensory and "default mode network" regions. However, little is known about brain mechanisms underlying tolerance of meal-induced gastric distension. We aimed to directly compare brain responses to gradual balloon distension and intragastric nutrient infusion and to explore the role of differential gut peptide release in these responses. MATERIALS AND METHODS: Brain responses to balloon- and nutrient-induced distension (to individually titrated pain or maximal satiation threshold) were measured in 15 healthy volunteers using H2(15)O-PET on 2 separate days in counterbalanced order...
September 14, 2016: NeuroImage
C D Balaban
Neuronal networks that are linked to the peripheral vestibular system contribute to gravitoinertial sensation, balance control, eye movement control, and autonomic function. Ascending connections to the limbic system and cerebral cortex are also important for motion perception and threat recognition, and play a role in comorbid balance and anxiety disorders. The vestibular system also shows remarkable plasticity, termed vestibular compensation. Activity in these networks is regulated by an interaction between: (1) intrinsic neurotransmitters of the inner ear, vestibular nerve, and vestibular nuclei; (2) neurotransmitters associated with thalamocortical and limbic pathways that receive projections originating in the vestibular nuclei; and (3) locus coeruleus and raphe (serotonergic and nonserotonergic) projections that influence the latter components...
2016: Handbook of Clinical Neurology
Yishul Wei, Jennifer R Ramautar, Michele A Colombo, Diederick Stoffers, Germán Gómez-Herrero, Wisse P van der Meijden, Bart H W Te Lindert, Ysbrand D van der Werf, Eus J W Van Someren
STUDY OBJECTIVES: Whereas both insomnia and altered interoception are core symptoms in affective disorders, their neural mechanisms remain insufficiently understood and have not previously been linked. Insomnia Disorder (ID) is characterized by sensory hypersensitivity during wakefulness and sleep. Previous studies on sensory processing in ID addressed external stimuli only, but not interoception. Interoceptive sensitivity can be studied quantitatively by measuring the cerebral cortical response to one's heartbeat (heartbeat-evoked potential, HEP)...
September 9, 2016: Sleep
Lorenz Leitner, Matthias Walter, Behnaz Jarrahi, Johann Wanek, Jörg Diefenbacher, Lars Michels, Martina D Liechti, Spyros S Kollias, Thomas M Kessler, Ulrich Mehnert
OBJECTIVE: To evaluate the applicability and precision of a novel infusion-drainage device (IDD) for standardised filling paradigms in neuro-urology and functional magnetic resonance imaging (fMRI) studies of lower urinary tract (LUT) (dys)function. SUBJECTS/PATIENTS AND METHODS: The IDD is based on electrohydrostatic actuation which was previously proven feasible in a prototype setup. The current design includes hydraulic cylinders and a motorised slider to provide force and motion...
September 12, 2016: BJU International
Stuart J McDougall, Haoyao Guo, Michael C Andresen
Emotional state is impacted by changes in visceral function, including blood pressure, breathing and digestion. A main line of viscerosensory information processing occurs first in the NTS. Here, in rats, we examined the synaptic characteristics of visceral afferent pathways to the central nucleus of the amygdala (CeA) in brainstem slices by recording from retrogradely labelled NTS projection neurons. We simultaneously recorded neuron pairs: one dye positive (i.e. NTS-CeA) and a second unlabelled neighbor. Graded shocks to the solitary tract (ST) always (93%) triggered EPSCs at CeA projecting NTS neurons...
September 12, 2016: Journal of Physiology
Jonas Zaman, Steven De Peuter, Ilse Van Diest, Omer Van den Bergh, Johan W S Vlaeyen
The growing body of research on interoceptive conditioning has predominantly focused on associative learning paradigms that investigated the formation of intero-interoceptive or extero-interoceptive associations. Yet, little research has explored whether interoceptive sensations can enter an intero-exteroceptive association. Therefore, in an interoceptive conditioning paradigm, healthy participants experienced a respiratory resistance for 8s, causing mild dyspnea (interoceptive conditioned stimulus, CS), that was either paired to an aversive electrocutaneous stimulus (unconditioned stimulus, US) (experimental condition, n=25), or presented in an unpaired fashion (control condition, n=25) during the acquisition phase...
September 8, 2016: International Journal of Psychophysiology
Mayte Parada, Marina Gérard, Kevin Larcher, Alain Dagher, Yitzchak M Binik
INTRODUCTION: Studies investigating brain indices of sexual arousal have begun to elucidate the brain's role in processing subjective arousal; however, most research has focused on men, used discrete ratings of subjective arousal, and used stimuli too short to induce significant arousal in women. AIM: To examine brain regions modulated by changes in subjective sexual arousal (SSA) rating intensity in men and women. METHODS: Two groups (20 men, 20 women) viewed movie clips (erotic or humorous) while continuously evaluating changes in their SSA using a Likert-like scale (0 = not aroused, 10 = most aroused) and answering discrete questions about liking the movies and wanting sexual stimulation...
October 2016: Journal of Sexual Medicine
Joanne Berriman, Richard J Stevenson, Zoe C Thayer, Elizabeth Thompson, Armin Mohamed, John D G Watson, Laurie A Miller
Interoception is the ability to consciously perceive internal bodily states. Neuroimaging suggests that the insula (IC) and anterior cingulate cortex (ACC) mediate interoception, while studies involving patients/animals with brain lesions suggest the medial temporal lobe (MTL) is particularly important. One reason for these contrasting conclusions may lie in the types of interoceptive task used by these different approaches. Some tasks probably require integration of current physiological state with mnemonic information (e...
September 5, 2016: Neuropsychologia
Sarah Kann, Sheng Zhang, Peter Manza, Hoi-Chung Leung, Chiang-Shan Ray Li
Resting state functional connectivity (rsFC) is widely used to examine cerebral functional organization. The imaging literature has described lateralization of insula activations during cognitive and affective processing. Evidence appears to support a role of the right-hemispheric insula in attentional orientation to salient stimulus, interoception, and physiological arousal and a role of the left-hemispheric insula in cognitive and affective control as well as perspective taking. Here, in a large data set of healthy adults, we examined lateralization of the rsFC of the anterior insula (AI) by computing a laterality index (LI) of connectivity with 54 regions from the Automated Anatomic Labeling atlas...
September 7, 2016: Brain Connectivity
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