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https://www.readbyqxmd.com/read/28535076/intraarticular-injection-of-a-cross-linked-sodium-hyaluronate-combined-with-triamcinolone-hexacetonide-cingal-to-provide-symptomatic-relief-of-osteoarthritis-of-the-knee-a-randomized-double-blind-placebo-controlled-multicenter-clinical-trial
#1
Laszlo Hangody, Robert Szody, Piotr Lukasik, Wojciech Zgadzaj, Endre Lénárt, Eva Dokoupilova, Daniela Bichovsk, Agnes Berta, Gabor Vasarhelyi, Andrea Ficzere, György Hangody, Gary Stevens, Miklos Szendroi
OBJECTIVE: To evaluate the efficacy and safety of an intraarticular injection of Cingal (Anika Therapeutics, Inc., Bedford, MA) compared with Monovisc (Anika Therapeutics, Inc., Bedford, MA) or saline for the treatment of knee osteoarthritis. DESIGN: This multicenter, double-blind, saline-controlled clinical trial randomized subjects with knee osteoarthritis (Kellgren-Lawrence grades I-III) to a single injection of Cingal (4 mL, 88 mg hyaluronic acid [HA] plus 18 mg triamcinolone hexacetonide [TH]), Monovisc (4 mL, 88 mg HA), or saline (4 mL, 0...
May 1, 2017: Cartilage
https://www.readbyqxmd.com/read/28532870/effects-of-medical-exercise-therapy-in-patients-with-hip-osteoarthritis-a-randomized-controlled-trial-with-six-months-follow-up-a-pilot-study
#2
Håvard Østerås, Fredrik Paulsberg, Stian Endré Olsen, Berit Østerås, Tom Arild Torstensen
BACKGROUND & AIMS: There is no consensus regarding what type of exercises, combination of exercises or exercise dosage is most effective in patients with long-term hip arthrosis. The goal of this study was to evaluate the effects of two different exercise programs related to dose-response relationships. METHOD: Prospective randomized controlled clinical trial with 6 months follow where 33 participants were randomly assigned to either high repetitive, high dosage medical exercise therapy (MET) (n = 16) or low dosage exercise therapy (ET) (n = 17)...
April 2017: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/28532493/distal-femoral-replacement-with-the-mml-system-a-single-center-experience-with-an-average-follow-up-of-86%C3%A2-months
#3
Andreas Toepfer, Norbert Harrasser, Paul-Ruben Schwarz, Florian Pohlig, Ulrich Lenze, Heinrich M L Mühlhofer, Ludger Gerdesmeyer, Ruediger von Eisenhart-Rothe, Christian Suren
BACKGROUND: The aim of this study was to compare the functional outcomes and complication rates after distal femoral replacement (DFR) performed with the modular Munich-Luebeck (MML) modular prosthesis (ESKA/Orthodynamics, Luebeck, Germany) in patients being treated for malignant disease or failed total knee arthroplasty. METHODS: A retrospective review of patient charts and a functional investigation (involving Musculoskeletal Tumor Society Score [MSTS], American Knee Society Score [AKSS], Oxford Knee Score [OKS], Western Ontario and McMaster Universities Osteoarthritis Index [WOMAC], Toronto Extremity Salvage Score [TESS], the 12-Item Short-Form [SF-12] Health Survey, and a failure classification system developed by Henderson et al...
May 22, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28532445/cross-cultural-adaptation-and-validation-of-the-spanish-version-of-the-oxford-hip-score-in-patients-with-hip-osteoarthritis
#4
Jesús Martín-Fernández, Pedro Gray-Laymón, Antonio Molina-Siguero, Javier Martínez-Martín, Roberto García-Maroto, Isidoro García-Sánchez, Lidia García-Pérez, Vanesa Ramos-García, Olga Castro-Casas, Amaia Bilbao
BACKGROUND: Osteoarthritis (OA) of the hip is a disease that entails a major burden for patients and the society as a whole. One way of measuring this burden for the patient is through impact on Health-related Quality of Life (HRQL). The Oxford Hip Score (OHS) is a well-known tool to measure HRQL in patients with OA of the hip. This study aims to assess the psychometric properties of the Spanish-adapted version of the OHS, including its reliability, validity, and sensitivity to change...
May 22, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28530031/celecoxib-for-osteoarthritis
#5
REVIEW
Livia Puljak, Ana Marin, Davorka Vrdoljak, Filipa Markotic, Ana Utrobicic, Peter Tugwell
BACKGROUND: Osteoarthritis (OA) is the most common form of arthritis and is caused by degeneration of the joint cartilage and growth of new bone, cartilage and connective tissue. It is often associated with major disability and impaired quality of life. There is currently no consensus on the best treatment to improve OA symptoms. Celecoxib is a selective non-steroidal anti-inflammatory drug (NSAID). OBJECTIVES: To assess the clinical benefits (pain, function, quality of life) and safety (withdrawals due to adverse effects, serious adverse effects, overall discontinuation rates) of celecoxib in osteoarthritis (OA)...
May 22, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28527701/reasons-for-and-functional-results-of-repeated-hip-arthroscopy-a-continuous-prospective-study-of-17-revisions-out-of-295-primary-hip-arthroscopies-at-mean-28-months-follow-up
#6
C Tissot, L Merlini, M Mercier, N Bonin
INTRODUCTION: The rate of iterative arthroscopy has been increasing over the last decade as the technique has grown. The results of and reasons for these revision procedures, however, are not exactly known. We therefore conducted a prospective study to shed light on 1) functional results and patient satisfaction following repeated arthroscopy, and 2) the relevant indications. HYPOTHESIS: Functional scores and patient satisfaction increase following repeated arthroscopy...
May 17, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28526995/two-cycles-of-plasma-rich-in-growth-factors-prgf-endoret-intra-articular-injections-improve-stiffness-and-activities-of-daily-living-but-not-pain-compared-to-one-cycle-on-patients-with-symptomatic-knee-osteoarthritis
#7
Víctor Vaquerizo, Sabino Padilla, José Javier Aguirre, Leire Begoña, Gorka Orive, Eduardo Anitua
PURPOSE: To assess the clinical efficacy and safety of a treatment based on one cycle versus two cycles of intra-articular injections of plasma rich in growth factors (PRGF-Endoret) on patients with knee osteoarthritis (OA). METHODS: Ninety patients with knee OA were included and evaluated. A total of 48 patients received one cycle (OC group) (3 injections on a weekly basis), while 42 patients received two cycles of PRGF-Endoret (TC group) spaced 6 months between them...
May 19, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28516223/two-stage-revision-hip-arthroplasty-in-periprosthetic-joint-infection-comparison-study-with-or-without-the-use-of-a-spacer
#8
Dariusz Marczak, Marek Synder, Marcin Sibiński, Michał Polguj, Julian Dudka, Jacek Kowalczewski
PURPOSE: The aim of this study was to compare two methods of two-stage surgery for PJI (periprosthetic joint infection) after THA (total hip arthroplasty): one with and one without the use of an antibiotic-loaded cement spacer. METHODS: This retrospective study was performed on 99 consecutive patients (99 hips) with a minimum follow-up of 24 months. Patients were divided into two groups: (1) in whom the operation was performed using a spacer, and (2) for whom a spacer was not used...
May 18, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28510478/two-tunnel-transtibial-repair-of-radial-meniscus-tears-produces-comparable-results-to-inside-out-repair-of-vertical-meniscus-tears
#9
Mark E Cinque, Andrew G Geeslin, Jorge Chahla, Grant J Dornan, Robert F LaPrade
BACKGROUND: Radial meniscus tears disrupt the circumferential fibers and thereby compromise meniscus integrity. Historically, radial tears were often treated with meniscectomy because of an incomplete understanding of the biomechanical consequences of these tears, limited information regarding the biomechanical performance of repair, and the technical difficulty associated with repair. There is a paucity of studies on the outcomes of the repair of radial meniscus tears. Purpose/Hypothesis: The purpose was to determine the outcomes of 2-tunnel transtibial repair of radial meniscus tears and compare these results to the outcomes of patients who underwent the repair of vertical meniscus tears with a minimum of 2-year follow-up...
May 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28509820/impact-of-preoperative-opioid-use-on-total-knee-arthroplasty-outcomes
#10
Savannah R Smith, Jennifer Bido, Jamie E Collins, Heidi Yang, Jeffrey N Katz, Elena Losina
BACKGROUND: There is growing concern about the use of opioids prior to total knee arthroplasty (TKA), and research has suggested that preoperative opioid use may lead to worse pain outcomes following surgery. We evaluated the pain relief achieved by TKA in patients who had and those who had not used opioids use before the procedure. METHODS: We augmented data from a prospective cohort study of TKA outcomes with opioid-use data abstracted from medical records. We collected patient-reported outcomes and demographic data before and 6 months after TKA...
May 17, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28506776/mindfulness-is-associated-with-treatment-response-from-non-pharmacological-exercise-interventions-in-knee-osteoarthritis
#11
Augustine C Lee, William F Harvey, Lori Lyn Price, Xingyi Han, Jeffrey B Driban, John B Wong, Mei Chung, Timothy E McAlindon, Chenchen Wang
OBJECTIVE: To examine the association between baseline mindfulness and response from exercise interventions in knee osteoarthritis (OA). DESIGN: Cohort Study; Responder analysis of a clinical trial subset SETTING: Urban tertiary care academic hospital PARTICIPANTS: 86 participants with symptomatic, radiographic knee OA (mean age, 60 years; 74% female; 48% white) INTERVENTIONS: 12 weeks (twice per week) of Tai Chi or Physical Therapy exercise MAIN OUTCOME MEASURE(S): Treatment response was defined using Osteoarthritis Research Society International criteria indicating meaningful improvements in the Western Ontario and McMaster Osteoarthritis Index (WOMAC) pain, function, or Patient Global Assessment scores...
May 12, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28506775/supervised-or-unsupervised-rehabilitation-after-total-hip-replacement-provides-similar-improvements-for-patients-a-randomised-controlled-trial
#12
Corinne Coulter, Diana M Perriman, Teresa M Neeman, Paul N Smith, Jennifer M Scarvell
OBJECTIVE: To determine do patients do better with unsupervised home PT or in an outpatient setting Are the outcomes after a supervised (centre-based) and an independent (home-based) physical rehabilitation program delivered in the early post-discharge phase (<8weeks) equivalent in an adult THR population. SETTING: Acute care public hospital in the region, supporting a population of almost 540,000. DESIGN: Single blinded randomised controlled trial...
May 12, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28506300/cross-cultural-adaptation-and-psychometric-analysis-of-the-arabic-version-of-the-oxford-knee-score-in-adult-male-with-knee-osteoarthritis
#13
Ahmad H Alghadir, Einas S Al-Eisa, Shahnawaz Anwer
BACKGROUND: There are varieties of self-assessment questionnaire used for the evaluation of pain, functional disability, and health related quality of life in individuals with knee osteoarthritis (OA). The present study intended to adapt and translate the oxford knee score into the Arabic and investigated its psychometric properties in adult male with knee OA. METHODS: Ninety-seven adult male (mean age 57.55 ± 11.49 years) with knee OA participated. Patients were requested to complete the adapted Arabic version of the Oxford knee score (OKS-Ar), reduced "Western Ontario and McMaster Universities Index (WOMAC)", and the Visual analogue scale (VAS)...
May 15, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28503072/long-term-clinical-benefit-and-cost-effectiveness-of-an-8-week-multimodal-knee-osteoarthritis-management-program-incorporating-intra-articular-sodium-hyaluronate-hyalgan-%C3%A2-injections
#14
Larry E Miller, Michael J Sloniewsky, Thomas E Gibbons, Janice G Johnston, Kent D Vosler, Saad Nasir
BACKGROUND: Given the poor long-term effectiveness of focused nonsurgical knee osteoarthritis (OA) treatments, alternative therapies are needed for patients who have unsuccessfully exhausted nonsurgical options. METHODS: A telephone interview was conducted in patients who participated in a single 8-week multimodal knee OA treatment program (mean follow-up: 3.7 years, range: 2.7-4.9 years). The program consisted of five intra-articular knee injections of sodium hyaluronate (Hyalgan(®)), with each injection given 1 week apart, structured physical therapy, knee bracing, and patient education...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28495818/application-of-minimal-important-differences-in-degenerative-knee-disease-outcomes-a-systematic-review-and-case-study-to-inform-bmj-rapid-recommendations
#15
Tahira Devji, Gordon H Guyatt, Lyubov Lytvyn, Romina Brignardello-Petersen, Farid Foroutan, Behnam Sadeghirad, Rachelle Buchbinder, Rudolf W Poolman, Ian A Harris, Alonso Carrasco-Labra, Reed A C Siemieniuk, Per O Vandvik
OBJECTIVES: To identify the most credible anchor-based minimal important differences (MIDs) for patient important outcomes in patients with degenerative knee disease, and to inform BMJ Rapid Recommendations for arthroscopic surgery versus conservative management DESIGN: Systematic review. OUTCOME MEASURES: Estimates of anchor-based MIDs, and their credibility, for knee symptoms and health-related quality of life (HRQoL). DATA SOURCES: MEDLINE, EMBASE and PsycINFO...
May 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28476542/short-term-clinical-results-of-intra-articular-prp-injections-for-early-osteoarthritis-of-the-knee
#16
Po-Hua Huang, Ching-Jen Wang, Wen-Yi Chou, Jun-Wen Wang, Jih-Yang Ko
PURPOSE: To assess the short-term results of repeated intra-articular platelet rich plasma (PRP) injections into the knee in patients with early osteoarthritis (OA) and to determine a better treatment protocol. METHODS: This is a retrospective study in 191 knees (127 patients) with minimum of 12 months follow-up. We compared the clinical results of three types of injection method, once a month, twice monthly, and three injections at monthly interval. The outcomes were assessed using Visual Rating Scale (VRS), functional score, knee score, range of motion (ROM), WOMAC Stiffness/Pain/Function score, IKDC score, before the first injection and at 12 months post treatment...
May 2, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28473871/lateral-wedges-with-and-without-custom-arch-support-for-people-with-medial-knee-osteoarthritis-and-pronated-feet-an-exploratory-randomized-crossover-study
#17
Michael A Hunt, Judit Takacs, Natasha M Krowchuk, Gillian L Hatfield, Rana S Hinman, Ryan Chang
BACKGROUND: Pronated foot posture is associated with many clinical and biomechanical outcomes unique to medial compartment knee osteoarthritis (OA). Though shoe-worn insole treatment, including lateral wedges, is commonly studied in this patient population, their effects on the specific subgroup of people with medial knee OA and concomitant pronated feet are unknown. The purpose of this study was to evaluate whether lateral wedge insoles with custom arch support are more beneficial than lateral wedge insoles alone for knee and foot symptoms in people with medial tibiofemoral knee osteoarthritis (OA) and pronated feet...
2017: Journal of Foot and Ankle Research
https://www.readbyqxmd.com/read/28472071/associations-between-mri-features-versus-knee-pain-severity-and-progression-data-from-the-vancouver-longitudinal-study-of-early-knee-osteoarthritis
#18
Eric C Sayre, Ali Guermazi, John M Esdaile, Jacek A Kopec, Joel Singer, Anona Thorne, Savvas Nicolaou, Jolanda Cibere
OBJECTIVE: To determine associations between features of osteoarthritis (OA) on MRI and knee pain severity and knee pain progression. DESIGN: Baseline, 3.3- and 7.5-year assessments were performed for 122 subjects with baseline knee pain (age 40-79), sample-weighted for population (with knee pain) representativeness. MRIs were scored for: osteophytes (0:absent to 3:large); cartilage (0:normal to 4:full thickness defect; 0/1 collapsed); subchondral sclerosis (0:none to 3:>50% of site), subchondral cyst (0:absent to 3:severe), bone marrow lesions (0:none to 3:≥50% of site); and meniscus (0:normal to 3:maceration/resection), in 6-8 regions each...
2017: PloS One
https://www.readbyqxmd.com/read/28472068/minimally-invasive-unicompartmental-knee-replacement-midterm-clinical-outcome
#19
Shaoqi Tian, Jiangjun Liu, Wanqing Yuan, Yuanhe Wang, Chengzhi Ha, Lun Liu, Qicai Li, Xu Yang, Kang Sun
OBJECTIVE: The purpose of this study was to explore the midterm clinical outcomes of unicompartmental knee replacement (UKR) for medial knee arthropathy through a minimally invasive approach (MIA). METHODS: From January 2006 to June 2010, 442 consecutive patients (485 knees) were included in the study. All patients underwent MIA-UKR with the mobile bearing Oxford phrase III prosthesis. The incision was made starting 1 cm medial to the medial pole of the patella and extending distally to the tibial tubercle...
2017: PloS One
https://www.readbyqxmd.com/read/28469486/a-double-blind-active-controlled-clinical-trial-of-sodium-bicarbonate-and-calcium-gluconate-in-the-treatment-of-bilateral-osteoarthritis-of-the-knee
#20
María Del Carmen Caamaño, Sandra García-Padilla, Miguel Ángel Duarte-Vázquez, Karla Elena González-Romero, Jorge L Rosado
OBJECTIVE: To evaluate the effect of intra-articular injections of sodium bicarbonate with a single (SBCG1) or double dose (SBCG2) of calcium gluconate administered monthly compared with methylprednisolone (MP) for treatment of knee osteoarthritis. METHODS: A 3-month, randomized, double-blind clinical trial with patients diagnosed with knee osteoarthritis (OA). The outcome variables were the Western Ontario-McMaster University Osteoarthritis Index (WOMAC) and the Lequesne functional index...
2017: Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders
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