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https://www.readbyqxmd.com/read/28433814/synovial-fluid-pro-inflammatory-profile-differs-according-to-the-characteristics-of-knee-pain
#1
Ying Ying Leung, Janet L Huebner, Benjamin Haaland, Steven Bak Siew Wong, Virginia Byers Kraus
OBJECTIVE: The role of inflammation and pain in osteoarthritis (OA) is not fully understood. We evaluated the association between pro-inflammatory biomarkers and pain. METHODS: We used baseline data and samples from a randomized controlled trial of colchicine for symptomatic knee OA. Severity of pain of the more symptomatic knee was assessed by NHANES-I criterion and WOMAC pain index. Pains on movement and at rest were self-reported on an 11-point Likert scale. Severity of radiographic tibiofemoral OA was assessed by Kellgren and Lawrence (KL) grade...
April 19, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28433425/effect-of-spinal-fusion-surgery-on-total-hip-arthroplasty-outcomes-a-matched-comparison-study
#2
Jing Loong Moses Loh, Lei Jiang, Hwei Chi Chong, Seng Jin Yeo, Ngai Nung Lo
BACKGROUND: Studies regarding postoperative outcomes after primary total hip arthroplasty (THA) in patients who have comorbid factors tend to focus on medical diseases. However, there is a paucity of literature examining the effect of a patient's orthopedic surgical history on outcomes after THA. Significantly, there are currently no studies on the effect of spinal fusion surgery on THA outcomes. METHODS: A review of 82 consecutive patients who had prior spinal fusion surgery who underwent elective THA from January 1, 2006 to December 31, 2015, was conducted...
March 22, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28431578/is-the-effectiveness-of-patellofemoral-bracing-modified-by-patellofemoral-alignment-and-trochlear-morphology
#3
Xi Zhang, Jillian P Eyles, Joanna Makovey, Matthew J Williams, David J Hunter
BACKGROUND: This study was performed to determine if the effectiveness of patellofemoral bracing as a treatment for patellofemoral osteoarthritis is influenced by patellofemoral joint alignment and trochlear morphology. We hypothesized that those with more extreme patellar malalignment would benefit more from bracing. METHODS: Thirty-eight patients who had received bracing as part of a comprehensive treatment plan for patellofemoral osteoarthritis were selected for this study...
April 21, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28426917/internet-cognitive-behaviour-therapy-for-depression-in-older-adults-with-knee-osteoarthritis-a-randomized-controlled-trial
#4
Kathleen A O'Moore, Jill M Newby, Gavin Andrews, David J Hunter, Kim Bennell, Jessica Smith, Alishia D Williams
Objective To determine the efficacy of an internet-based cognitive behavioural therapy (iCBT) program for depression in older adults with osteoarthritis of the knee and comorbid major depressive disorder (MDD). We conducted a RCT in sixty-nine adults (≥ 50 years) meeting criteria for MDD and osteoarthritis of the knee with 1-week post intervention (week 11) and 3-month follow-up (week 24) end points. Patients were allocated to either a 10-week iCBT program for depression added to treatment as usual (TAU) or to a TAU control group...
April 20, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28425672/evaluating-therapeutic-effect-on-womac-subscales-in-osteoarthritis-rcts-when-model-choice-matters
#5
Giulia Lorenzoni, Danila Azzolina, Nicola Soriani, Dario Gregori
RATIONALE, AIMS, AND OBJECTIVES: The study aimed at developing a method for modelling the Western Ontario and McMaster Universities index (WOMAC), accounting for correlation between its subscales and for heterogeneity of treatment effect (HTE), using data from 2 twin trials on knee osteoarthritis. METHOD: Two randomized, double-blind, placebo-controlled clinical trials (twin trials). Studies aimed at investigating the effectiveness of a pharmacological treatment on clinical outcomes of knee osteoarthritis, measured using WOMAC index...
April 20, 2017: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/28421358/vitamin-d-supplementation-for-the-management-of-knee-osteoarthritis-a-systematic-review-of-randomized-controlled-trials
#6
Salman Hussain, Ambrish Singh, Mohd Akhtar, Abul Kalam Najmi
Conflicting evidence exists concerning the supplementation of vitamin D in knee osteoarthritis condition. This systematic literature review was done to explore the effects of vitamin D supplementation in the management of knee osteoarthritis. Electronic literature search was done in databases like PubMed(®), Embase(®), and Cochrane CENTRAL from inception to 6th July 2016. The quality of included Randomized Controlled Trials (RCTs) was assessed using Cochrane risk of bias tool. We considered change in Western Ontario and McMaster Universities (WOMAC) index, Visual Analog Scale (VAS) and Functional Pain Score (FPS) as the primary outcome measure...
April 18, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28419032/formal-physical-therapy-after-total-hip-arthroplasty-is-not-required-a-randomized-controlled-trial
#7
Matthew S Austin, Brian T Urbani, Andrew N Fleischman, Navin D Fernando, James J Purtill, William J Hozack, Javad Parvizi, Richard H Rothman
BACKGROUND: The value of formal physical therapy after total hip arthroplasty is unknown. With substantial changes that have occurred in surgical and anesthesia techniques, self-directed therapy may be efficacious in restoring function to patients undergoing total hip arthroplasty. METHODS: We conducted a single-center, randomized trial of 120 patients undergoing primary, unilateral total hip arthroplasty who were eligible for direct home discharge. The experimental group followed a self-directed home exercise program for 10 weeks...
April 19, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28418842/effects-of-tlr-2-nf-%C3%AE%C2%BAb-signaling-pathway-on-the-occurrence-of-degenerative-knee-osteoarthritis-an-in-vivo-and-in-vitro-study
#8
Yi-Xun Liu, Guo-Dong Wang, Xiao Wang, Yong-Le Zhang, Tian-Lun Zhang
The study aims to explore the effects of TLR-2/NF-κB signaling pathway on the occurrence of degenerative knee osteoarthritis (OA). Degenerative knee OA and normal cartilage samples were collected from patients with degenerative knee OA receiving total knee arthroplasty and amputation. Expressions of TLR-2, NF-κB and MMP-13 were determined by qRT-PCR and immunochemistry. The chondrocytes were divided into control, IL-1β, IL-1β + anti-TLR-2 and IL-1β + PDTC groups. MTT assay and flow cytometry were performed to determine proliferation and apoptosis of the chondrocytes...
March 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28418269/is-a-hollow-centralizer-necessary-when-using-a-polished-tapered-cemented-femoral-stem
#9
Erik Weber, Christer Olsson, Uldis Kesteris, Gunnar Flivik
Background and purpose - A tapered, polished and collarless stem is normally equipped with a hollow centralizer to prevent the stem from becoming end-bearing in the cement as the stem subsides. In a randomized clinical trial, we evaluated such a stem (MS-30), which was initially introduced with a solid centralizer but was later recommended to be fitted with a hollow centralizer. We hypothesized that while the stem would sink more, it would become rotationally stable and have less retroversion with a hollow centralizer than with a solid centralizer...
April 18, 2017: Acta Orthopaedica
https://www.readbyqxmd.com/read/28409138/range-of-motion-predictability-after-total-knee-arthroplasty-with-medial-pivot-prosthesis
#10
Lúcio Honório de Carvalho Júnior, Bruno Presses Teixeira, Cláudio Otávio da Silva Bernardes, Luiz Fernando Machado Soares, Matheus Braga Jacques Gonçalves, Eduardo Frois Temponi
OBJECTIVE: To assess whether there the final range of motion (ROM) results achieved by patients undergoing total knee arthroplasty (TKA) with prosthesis using Medial Pivot design are predictable. METHODS: Between January and August of 2014, 155 patients with primary osteoarthritis of knee who underwent TKA using the prosthesis ADVANCE(®) Medial Pivot were prospectively assessed. All ROM measures were made and recorded before, during, and after surgery. All patients were clinically assessed preoperatively and postoperatively (15, 45 days, three months, six months, one year, and annually thereafter after surgery); their functional status was assessed using the WOMAC questionnaire...
March 2017: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/28404609/moxibustion-versus-diclofenac-sodium-gel-for-the-treatment-of-knee-osteoarthritis-a-study-protocol-for-a-double-blinded-double-placebo-randomised-controlled-trial
#11
Jian-Ying Zhou, Ling Luo, Lin-Lin Zhu, Hai-Yan Yin, Qiaofeng Wu, Jia-Xi Peng, Cheng-Shun Zhang, Peng Lv, Yong Tang, Shu-Guang Yu
INTRODUCTION: Knee osteoarthritis is a common form of arthritis in elderly patients that is characterised by pain and functional limitation. Moxibustion has been employed to relieve chronic pain as an alternative therapy for knee osteoarthritis. However, the evidence of its efficacy is equivocal due to the low methodological quality in most clinical studies. Therefore, we are performing a double-blinded, double-placebo, randomised controlled trial to evaluate the efficacy of moxibustion in participants with knee osteoarthritis...
April 12, 2017: BMJ Open
https://www.readbyqxmd.com/read/28399883/role-of-self-efficacy-and-social-support-in-short-term-recovery-after-total-hip-replacement-a-prospective-cohort-study
#12
Espen Andreas Brembo, Heidi Kapstad, Sandra Van Dulmen, Hilde Eide
BACKGROUND: Despite the overall success of total hip replacement (THR) in patients with symptomatic osteoarthritis (OA), up to one-quarter of patients report suboptimal recovery. The aim of this study was to determine whether social support and general self-efficacy predict variability in short-term recovery in a Norwegian cohort. METHODS: We performed secondary analysis of a prospective multicenter study of 223 patients who underwent THR for OA in 2003-2004. The total score of the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) at 3 months after surgery was used as the recovery variable...
April 11, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28390882/risk-benefit-on-quality-of-life-after-total-knee-arthroplasty-in-octogenarians
#13
Alejandro Lizaur-Utrilla, Daniel Martinez-Mendez, Francisco A Miralles-Muñoz, Luis Marco-Gomez, Fernando A Lopez-Prats
BACKGROUND: Clinical outcomes of total knee arthroplasty (TKA) in very older patients have been widely studied, but the available evidence on quality of life (QOL) is limited. The objective was to evaluate the impact of TKA on the QOL in octogenarian patients and assess whether the risk-benefit justified surgery. METHODS: Prospective study comparing 143 octogenarian and 149 septuagenarian patients. QOL was assessed with the Short Form-12 (SF-12) and the Western Ontario and McMaster Universities Arthritis Index (WOMAC) questionnaires and functional outcomes with the Knee Society score (KSS)...
March 16, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28386565/a-10-year-follow-up-of-two-incision-and-modified-watson-jones-total-hip-arthroplasty-in-patients-with-osteonecrosis-of-the-femoral-head
#14
Shih-Jie Lin, Tsan-Wen Huang, Po-Chun Lin, Feng-Chih Kuo, Kuo-Ti Peng, Kuo-Chin Huang, Mel S Lee
Long-term data and information indicating whether minimally invasive surgery (MIS) approaches are safe and effective with total hip arthroplasty (THA) are lacking. Between 2004 and 2006, 75 patients with alcohol-related osteonecrosis of the femoral head (ONFH) who underwent 75 THAs with the two-incision approach were studied. The medical records, radiographic parameters, and functional outcomes were collected prospectively. All data were compared with those for matched patients who underwent a modified Watson-Jones (WJ) approach...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28386499/total-knee-arthroplasty-in-severe-valgus-osteoarthritis-excellent-early-results-in-a-90-year-old-patient-with-a-valgus-deformity-of-47%C3%A2
#15
Petros Ismailidis, Rolf Kernen, Sebastian Andreas Mueller
Grade III valgus deformity (tibiofemoral alignment > 20°) is present in only 0.5% of patients receiving total knee arthroplasty. Furthermore, cases with a valgus deformity exceeding 40° are even rarer. Since they mostly affect elderly, polymorbid patients, successful outcome means a great challenge. We report on a case of a 90-year-old patient with a valgus deformity of 47°. The patient was preoperatively restricted to a wheel chair, unable to walk, and only able to stand for a few seconds. The maximal knee flexion was 100°, and there was an extension deficit of 15°...
2017: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/28384564/effect-of-acupuncture-on-aromatase-inhibitor-induced-arthralgia-in-patients-with-breast-cancer-a-meta-analysis-of-randomized-controlled-trials
#16
Lawrence Chen, Chao-Chun Lin, Tsai-Wei Huang, Yi-Chun Kuan, Yao-Hsien Huang, Hung-Chou Chen, Chun-Yu Kao, Chih-Ming Su, Ka-Wai Tam
PURPOSE: Aromatase inhibitor (AI)-induced arthralgia (AIA) is a common side effect that may lead to premature discontinuation of effective hormonal therapy in patients with breast cancer. Acupuncture may relieve joint pain in patients with AIA. We conducted a meta-analysis of randomized controlled trials (RCTs) to evaluate the effectiveness of acupuncture in pain relief in AIA. METHODS: The PubMed, Embase, Cochrane Library, and Scopus databases and the ClinicalTrials...
April 3, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28383440/cementless-total-hip-arthroplasty-with-extended-sliding-trochanteric-osteotomy-for-high-congenital-hip-dislocation-a-retrospective-study
#17
Zhengliang Luo, Min Chen, Fei Hu, Zhe Ni, Xiaofeng Ji, Xiaoqi Zhang, Peng Cheng, Xifu Shang
Total hip arthroplasty (THA) for high congenital hip dislocation (CHD) is technically demanding. The purpose of this retrospective study was to evaluate the results of cementless THA combined with extended sliding trochanteric osteotomy. We also assessed whether chronic low back pain was relieved after surgery.The study included 19 patients (23 hips) with high CHD treated with cementless THA using extended sliding trochanteric osteotomy technique. Clinical and radiographic outcomes were evaluated.Harris Hip Score, WOMAC score, visual analog scale for low back pain and Trendelenburg sign were significantly improved (P < 0...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28379872/patients-with-knee-osteoarthritis-who-score-highly-on-the-paindetect-questionnaire-present-with-multi-modality-hyperalgesia-increased-pain-and-impaired-physical-function
#18
Penny Moss, Heather A E Benson, Rob Will, Anthony Wright
OBJECTIVES: PainDETECT is a self-report questionnaire that can be used to identify features of neuropathic pain. A proportion of patients with knee osteoarthritis score highly on the PainDETECT questionnaire. This study aimed to determine whether those with a higher "positive neuropathic" score on the PainDETECT questionnaire also had greater pain, hypersensitivity and reduced function compared to individuals with knee OA with lower PainDETECT scores. METHODS: 130 participants with knee OA completed the PainDETECT, Western Ontario and McMaster Universities Arthritis Index (WOMAC) and Pain Quality Assessment Scale (PQAS) questionnaires...
April 4, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28378275/what-is-the-responsiveness-and-respondent-burden-of-the-new-knee-society-score
#19
Rajesh N Maniar, Parul R Maniar, Debashish Chanda, Dnyaneshwar Gajbhare, Toral Chouhan
BACKGROUND: Although the new Knee Society score (NKSS) has been validated by a task force, a longitudinal study of the same cohort of patients to evaluate the score's responsiveness and respondent burden has not been reported, to our knowledge. QUESTIONS/PURPOSES: We analyzed the NKSS for (1) responsiveness; (2) respondent burden; and (3) convergent validity in 148 patients studied longitudinally during more than 1 year. METHODS: During an 8-month period, 165 patients underwent TKA by the same surgeon at our institution, of whom 148 (90%) completed this study; the others were excluded because of distance to travel or loss to followup at the specified time...
April 4, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28373980/clinical-results-and-serum-metal-ion-concentrations-following-ceramic-on-metal-total-hip-arthroplasty-at-a-mean-follow-up-of-60-months
#20
W Maurer-Ertl, D Pranckh-Matzke, J Friesenbichler, G Bratschitsch, L A Holzer, M Maier, A Leithner
Background. Increased metal ion levels following total hip arthroplasty (THA) with metal-on-metal bearings are a highly debated topic. Local soft tissue reactions with chronic pain and systemic side effects such as neuropathy are described. The aim of the current study was to determine the serum metal ion concentrations of Cobalt (Co) and Chrome (Cr) after THA with a ceramic-on-metal (CoM) bearing. Patients and Methods. Between 2008 and 2010, 20 patients underwent THA using a CoM bearing. Clinical function was evaluated by standardized scores systems (Harris Hip Score and WOMAC Score) and radiological examination included X-rays...
2017: BioMed Research International
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