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Remote ischemic conditioning reduces myocardial infarct size and edema in patients with ST-segment elevation myocardial infarction

Steven K White, Georg M Frohlich, Daniel M Sado, Viviana Maestrini, Marianna Fontana, Thomas A Treibel, Shana Tehrani, Andrew S Flett, Pascal Meier, Cono Ariti, John R Davies, James C Moon, Derek M Yellon, Derek J Hausenloy
OBJECTIVES: This study aimed to determine whether remote ischemic conditioning (RIC) initiated prior to primary percutaneous coronary intervention (PPCI) could reduce myocardial infarct (MI) size in patients presenting with ST-segment elevation myocardial infarction. BACKGROUND: RIC, using transient limb ischemia and reperfusion, can protect the heart against acute ischemia-reperfusion injury. Whether RIC can reduce MI size, assessed by cardiac magnetic resonance (CMR), is unknown...
January 2015: JACC. Cardiovascular Interventions
Gabriele Crimi, Silvia Pica, Claudia Raineri, Ezio Bramucci, Gaetano M De Ferrari, Catherine Klersy, Marco Ferlini, Barbara Marinoni, Alessandra Repetto, Maurizio Romeo, Vittorio Rosti, Margherita Massa, Arturo Raisaro, Sergio Leonardi, Paolo Rubartelli, Luigi Oltrona Visconti, Maurizio Ferrario
OBJECTIVES: This study sought to evaluate whether remote ischemic post-conditioning (RIPC) could reduce enzymatic infarct size in patients with anterior ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention (pPCI). BACKGROUND: Myocardial reperfusion injury may attenuate the benefit of pPCI. In animal models, RIPC mitigates myocardial reperfusion injury. METHODS: One hundred patients with anterior ST-segment elevation myocardial infarction and occluded left anterior descending artery were randomized to pPCI + RIPC (n = 50) or conventional pPCI (n = 50)...
October 2013: JACC. Cardiovascular Interventions
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