Yaiza Potes, Juan C Bermejo-Millo, Catarina Mendes, José P Castelão-Baptista, Andrea Díaz-Luis, Zulema Pérez-Martínez, Juan J Solano, Vilma A Sardão, Paulo J Oliveira, Beatriz Caballero, Ana Coto-Montes, Ignacio Vega-Naredo
During aging, muscle regenerative capacities decline, which is concomitant with the loss of satellite cells that enter in a state of irreversible senescence. However, what mechanisms are involved in myogenic senescence and differentiation are largely unknown. Here, we showed that early-passage or "young" C2C12 myoblasts activated the redox-sensitive p66Shc signaling pathway, exhibited a strong antioxidant protection and a bioenergetic profile relying predominantly on OXPHOS, responses that decrease progressively during differentiation...
March 8, 2024: Cell Death & Disease